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Home My WebLink About1891 RUTHERFORD RD; ; CB013313; PermitCity of Carlsbad 1635 Faraday Av Carlsbad, CA 92008 12-20-2001 Commercial/Industrial Permit Permit No: CB013313 Building Inspection Request Line (760) 602-2725 · )ob Address: Permit Type: Parcel No: Valuation: Occupancy Group: Project Title: 12/20/2001 1891 RUTHERFORD RD CBAD Tl Sub Type: 2121203600 Lot#: $579,999.00 Construction Type: Reference #: ISIS PHARM-19,000 SF TI-WARHS, INDUST 0 IIIN Status: Applied: Entered By: ISSUED 10/19/2001 RMA Plan Approved: LAB/OFFICE TO LAB/OFFICE Applicant: Issued: 12/20/2001 Inspect Area: Owner: GOOD & ROBERTS INC. DIVERSIFIED CARLSBAD 47!Q% ~~/01 0002 01 . CGP 1090 JOSHUA WAY VISTA, CA 92083 619-598-7614 4330 LA JOLLA VILLAGE DR #110 SAN DIEGO CA 92122 'i F '!' Total Fees: $5,769.94 Total Payments To Date: '$300.00 Balance Due: $5,469.94 Building Permit Add'I Building Permit Fee Plan Check .Add'.I Plan Check Fee Plan Check Discount Strong Motion Fee Park Fee LFM Fee Bridge Fee BTD #2 Fee BTD #3 Fee Renewal Fee Add'I Renewal Fee Other Building Fee Pot. Water Con. Fee Meter Size Add'IPot. Water Con. Fee Reel. Water Con. Fee lnspecto~ $-1,987.36 Meter Size $0.00 Add'I Reel. Water Con. Fee $0.00 $1,291.78 Meter Fee $0.00 $0.00 SDCWA Fee $0.00 $0.00 CFD Payoff Fee $0.00 $121.80 PFF $0.00 $0.00 . PFF (CFO Fund) $0.00 $0.00 License Tax $0.00 $0.00 License Tax (CFO Fund) $0.00 $0.00 Traffic Impact Fee $0.00 $0.00 Traffic Impact (CFO Fund) $0.00 $0.00 PLUMBING TOTAL $413.00 $0.00 ELECTRICAL TOTAL $1,697.50 $0.00 MECHANICAL TOTAL $258.50 $0.00 Master Drainage Fee $0.00 Sewer Fee $0.00 $0.00 Redev Parking Fee $0.00 $0.00 Additional Fees $0.00 TOT AL PERMIT FEES $5,769.94 FINAL APPROVAL Date: 1/4~~ Clearance: _____ _ NOTICE: Please take NOTICE.that approval of your project includes the "Imposition" of fees, dedications, reservations, or other exactions hereafter collectively referred to as "fees/exactions." You have 90 days from the date this permit was issued to protest imposition of these fees/exactions. If you protest them, you must follow the protest procedures set forth in Government Code Section 66020(a), and file the.protest and any other required information with the City Manager for processing in accordance with Carlsbad Municipal Code Section 3.32.030. Failure to timely follow that procedure will bar any subsequent legal action to attack, review, set aside, void, or annul their imposition. You are hereby FURTHER NOTIFIED that your right to protest the specified fees/exactions DOES NOT APPLY to water and sewer connection fees and capactiy changes, n9r planning, zoning, grading or other similar application processing or service fees in connection with this project. NOR DOES IT APPLY to any fees/exactions of which vou have oreviouslv been aiven a NOTICE similar to this or as to which the statute of limitations has oreviouslv otherwise exoired. 02 5469-94 ···<ii \ '·· PERMIT APPLICATION Plan Ck. Deposit CITY OF CARLSBAD BUILDING DEPARTMENi "1635 Faraday Ave., Carlsbad, CA 92008 Validated By _____ _..,."'""_,_ __ _ Total # of units -# of Bedrooms ,-,,,' ... -.: N e ·====-.,, Address '.5/ __ ,_1C,O.~lIIAPTQ.f!/CQ."1P(t,1'('::~e!',"'"~~:-"::'.':::'~ , City State/Zip Telephone# (Sec. 7031.5 Business and Professions Code: Any City or County which requires a permit to construct, alter, improve, demolish or repair any structure, prior to its issuance, also requires the applicant for such permit to file a signed statement that he is licensed pursuant to the provisions of the Contractor's License Law [Chapter 9, commending with Section 7000 of Division 3 of the Business and Professions Code) or that he is exempt therefrom, and the basis for the alleged exemption. Any violation of Section 7031.5 by any applicant for a permit subjects the applicant to a civil penalty of not more than five hundred dollars [$500)). ~4ood,. t i<'oc£.-1~ .Z~o Co0¢>tc,.a..LA ct::: \), ~ Cit 1:(pv sz=,g-TulY Name 1 I Address 12. City State/Zip r!elepho~ r CJ State License# > '1' SS-License Class l2 City Business License #-=----1T.l'pr>-,c,.p,..__J q i7 0 Cf~ l:1DJ<'. A:tck, kc/4>& AL1 ½Y fz;.o-d1¼ ·Ss\:::gro >iG<J .~e~ cA-'-la 1 ~ Design~r Name/) I 4--uV Address City State/Zip Telephone State License # ~ u.-1 2 ".'.> L~\ .. ,. W,0:JY!'.J;B$:.99.MFENS"AJION:,;,,. /.. . ; . <" .a.'. :,.:,. ;_.; ~.--.'~-.: -:_--::::.:· .. :L . .:...:, .,--i .. ,''./i :-;,: ... ,-,~ __ :;, ;,-",;>.:,'./,;,1.(;~;,;.";;2'.,,:;::;>J,;;~,v: r:+\lF?; --7>·o,·.-.-. Workers' Compensation Declaration: I hereby affirm under penalty of perjury one of the following declarations: D I have and will maintain a certificate of consent to self-insure for workers' compensation as provided by Section 3700 of the Labor Code, for the performance f h work for which this permit is issued. have and will maintain workers' compensation, as required by Section 3700 of the Labor Code, for the performance of the work for which this permit is My worker's compensatioq i_nsurance carrier and policy number are: Insurance Company ~iC. loM{):fl\S,?....illA Policy No. D:-:3 ~?of Expiration Date (c) • { ·o2- (THIS SECTION NEED NOT BE COMPLETED IF THE PERMIT IS FOR ONE HUNDRED DOLLARS ($100) OR LESS) D CERTIFICATE OF EXEMPTION: I certify that in the performance of the work for which this permit is issued, I shall not employ any person in any manner so as to become subject to the Workers' Compensation Laws of California. WARNING: Failure to secure workers' compensation coverage is unlawful, and shall subject .an employer to criminal penalties and civil fines up to one hundred thousand dollars {$100,000), in cost of compensation, damages as provided for in Section 3706 of the Labor code, interest and attorney's fees. SIGNATURE·--,----b::;;.,r,c,A.,.e_~~---::-:--:---::-:--::-:--::-:~-:-:-::-=:-::=---::-:=-:-:-::-:-:-:::::-::--:-DATE t 2-2.tJ --Q) ~itEQ.'\&.\'t~ijfiuJ~pi;)::l:i;;Ec~ll.4.tJP.~·--., ... -;,,.·. .., ::· : __ :,_~ .': ·. '.'_ ~~~ •. :: .::.· .:·~·-· .. ,.:, ?t:C:::'.':~·:,:;:;·:.~·;;;:_~;:;;-;s,;tf-'.-:~.:,'.~'.:ifil::r.:·'..-h.:::::~:::r· I hereby affirm that I am exempt from the Contractor's License Law for the following-reason: 0 I, as owner of the property or my employees with wages as their sole compensation, will db the work and the structure is not intended or offered for sale (Sec. 7044, Business and Professions Code: The Contractor's License Law does not apply to an owner of property who builds· or improves thereon, and who does such work himself or through his own employees, provided that such improvements are not intended or offered for sale. If, however, the building or improvement is sold within one year of completion, the owner-builder will have the burden of proving that he did not build or improve for the purpose of sale). D I, as owner of the property, am exclusively contracting with licensed contractors to construct the project (Sec. 7044, Business and Professions Code: The Contractor's License Law does not apply to an owner of property who builds or improves thereon, and contracts for such projects with contractor(s) licensed pursuant to the Contractor's License Law). D I am exempt under Section ______ Business and Professions Code for this 'reason: 1. I personally plan to provide the major labor and materials for construction-ofthe proposed property improvement. D YES ONO 2. I (have / have not) signed an application for a building permit for toe proposed work. 3. I have contracted _with the following person (firm) to provide the proposed construction (include name / address I phone number/ contractors license number): 4. I plan to provide portions of the work, but I have hired the following person to coordinate, supervise and provide the major work (include name / address / phone number/ contractors license number): _____________________________________________ _ 5. I will provide some of the work, but I have contracted (hired) the following persons to provide the work indicated (include name / address / phone number / type of work):. _______________________________________________________ _ Is the applicant or future building occupant required to submit a business plan, acutely hazardous materials registrati program under Sections 25505, 25533 or 25534 of the Presley-Tanner Hazardous Substance Account Act? D YES Is th_e applicant or future building occupant required to obtain a permit from the air pollution control di Is the facility to be constructed within 1,000 feet of the outer boundary of a school site 7 ov,~ IF ANY OF THE ANSWERS ARE YES, A FINAL CERTIFICATE OF OCCUPANCY MAY NOT BEJSSUE UNLESS REQUIREMENTS OF THE OFFICE OF EMERGENCY SERVICES AND THE AIR POLLUTION CONTROL DISTRICT. E APPLICANT HAS MET OR IS MEETING THE ~.:.d..qQ~TRQJr.UQ1flr_jJ\l_Q,!f:'~~AG~!IIPY.i',~··;.;:,· :'-._'::,!,··:..::.._.:._·,. I hereby affirm that there is a construction lending agency for the performance of the work for which this permit is issued (Sec. 3097(i) Civil Code). LENDER'S NAME LENDER'S ADDRESS ;a;;::'.:1APfl!lCAN]CERTIFICAJlON ..• ·' ·. ""·":':~1 , , .. ,. ·. ~ · ...... ,. . :,·:.-__:_. -·-· ~~-:~:'..'i?JI:L}~:,;Z:, · :,_._;:::·;,:,;;~;~'].J::7:f''x~7J7':;:f '' ··. I certify that I have read the application and state that the above information is-correct and that the information on the plans is accurate. I agree to comply with all City ordinances and State laws relating to building construction. I hereby authorize representatives of the Citt of Carlsbad to enter upon the above mentioned property for inspection purposes. I ALSO AGREE TO SAVE, INDEMNIFY AND KEEP HARMLESS THE CITY OF CARLSBAD AGAINST ALL LIABILITIES, JUDGMENTS, COSTS AND EXPENSES WHICH MAY IN ANY WAY ACCRUE AGAINST SAID CITY IN CONSEQUENCE OF THE GRANTING OF THIS PERMIT. OSHA: An OSHA permit is required for excavations over 5'0" deep and demolition or construction of structures over 3 stories in height. EXPIRATION: Every permit issued by the building Off · e provisions of this Code shall expire by limitation and become null and void if the building or work authorized by such permit is not commencedw' · 180 days from th date of such permit or if the building or work authorized by such permit is suspended or abandoned at any time after the work is commenced f a period of 180 days ection 106.4.4 Uniform Building Code). ; J APPLICANT'S SIGNATURE --t:::::::::::-;:;,,""~;;:,""'-:;_______________ DATE 10 l-1 VP I I I YELLOW: Applicant PINK: Finance UNSCHEDULED BUILDING INSPECTION DATE . 9//>/4~ ; . 1-:J//$ 13311 PERMIT # 2181 s= INSPECTOR ,,,_/? ____ _ . PLAN CHECK# ____ _ JOB ADDRESS /891 t?//~~¢/ttJ, DESCRIPTION _____ ...,.___,. ___________ _ CODE DESCRIPTION . ACT COMMENTS Inspection List Permit#: CB013113 Type: Tl Date Inspection Item 09/12/2002 89 Final Combo 09/03/2002 89 Final Combo 07/16/2002 89 Final Combo 12/28/2001 12 Steel/Bond Beam 12/2~/2001 14 Frame/Steel/Bolting/Weldin 12/21/2001 14 Frame/Steel/Bolting/Weldin 12/20/2001 12 Steel/Bond Beam 11/16/2001 11 Ftg/Foundation/Piers Thursday, September 12, 2002 INDUST Inspector Act TP AP TP co TP CA TP AP TP co TP NR TP co TP AP ISIS PHARM-1200 SF MEZZANINE MECHANICAL ONLY Comments BY CONT. MEZ. MTL PAN DECK MEZ. MET DECK MEZ. DECK SPRD FTNS AND G.B. FOR MEZ Page 1 of 1 l •J Inf orma,tion ~ • .To Build On Engineering • Consulting • Testing REPORT OF CONCRETE COMPRESSION TEST RECEIVED MAR 18 2002 ENGINEERING DEPARTMENT TESTED FOR: JACKIE PROJECT: ISIS PHARMACUETICALS HDR ARCHTICTURE, INC. 1891 RUTHERFORD RD., CARLSBAD 9444 FARNfiN,f ST., SUITE 300 SAN DIEGO, CA 92123 DATE: January 30, 2002 - FIELD DATA: LOCATION OF PLACEMENT EQUIPMENT PADS @ H & 1 REVISION #1 OUR REPORT NO.: 059-10202-14 DATE PLACED TIME January 30, 2002 4 1/2. SUPPLIER DELIVE.RY-TICKET NO./fRUCK NO. MIX NUMBER AND PROPORTIONS PALOMAR TRANSIT MIX 1237959 SLUMP, IN. AIR CONTENT, % AIR TEMPERATURE, °F CONCRETE TEMPERATURE, °F DATE RECEIVED IN LAB FIELD DATA SUBMITTED BY MIX DATA SUBMITTED BY 70 78 January 31, 2002 R. MOTSINGER PALOMAR TRANSIT MIX CEMENT WATER FINE AGGREGATE COARSE AGGREGATE ADMIXTURE 304009 TYPE II NOTE: APPLICAB~E A_STM STANDARDS.UNLESS OTHERWISE INDICA TEO. SLUMP. C 14H7. AIR CONTENT. C2l Ml"(EXCLUOING SEC. 6). TE~:PERA TU.RE. C IOG4·~?!0:J,. ::,'_~IN~E~S, Cl 1-90 (EXCLUDING_ SEC. ~.2.2). SAMPLING. C 172-W -----·---· --------· ---.. I SPECIMEN : TEST LABORATORY I IDENTIFICATION" AGE NUMBER OR SET NO. · (DAYS) 2084 2084 2084 2084 A B C D 7 28 28 COMPRESSION TEST RESULTS ASTM C39-96; C1231·93 -···--·--·--,..· --- TOTAL CYLINDER DATE OF LOAD DIAMETER TEST (LBS.) (IN.) ·----·----·- 02/06/02 130000 6.00 02/27/02 178000 6.00 02/27/02 184000 6.00 -··--·--------·--. -----..... 1 .. ···-·-·-·---· -----· , CYLINDER • COMPRESSIVE , AREA . : STRENGTH ; (SQ, IN.) (PSI) 28.27 28.27 2~.27 4600 6300 6510 TYPE OF BREAK Columnar Cone & Shear Cone & Split i . I -----'--------·-; - SPECIFICATIONS ; 28 ·--------------------~CQNf02~t1fi~ 3000 : j ------·---·· ------------------ REMARKS: X Cylinders made by·PSI repre~entahve. Cylinders made by Architect's or Contracte<'s represenlahve. Cyhnders.p,cked up by PSI. ~ representative. Cylinders delivered to PSI laborato,y. X Test results comply with applicable specifications. Test results do not comply with applicable specificahons. All cylinders capped in accordance with ASTM C617-94. Respectfully submitted, Professional Se ice Industries, Inc. cc: City of Carlsb~d, Good and Robers, Tim Heinichen THESE TEST RESULTS APPlY ONLY TO THE SPECIFIC SAMPLES TESTED AND MA.Y NOT BE INDICATIVE Cl' THE ENTIRE CONCRETE PLACEMENT. REPORTS MAY NOT BE REPRODUCED. EXCEPT IN FULL. WITHOUT WRITTEN PERMISSION BY PRCl'ESSl~L SERVICE INDUSTRIES. INC. . Psi A-2oo-c <eJF Professional Service Industries, Inc.• 6867 Nancy Ridge Drive, Suite E • San Diego, CA 92121 • Phone 858/455-0544 • Fax 858/455-1170 · L •• r,. ;' lnjOrmation ~.,-,• .To Build On Page_1_of_ Enf!lneerlng • ConJulting • Testing INSPECTION REPORT CLIENT1:Bf S 11B'LA-ElA~ DATE 3, (A 1 02. Architect _ _..-lJQ ...... ~._.{l_'""':=-="------------------ Engineer_DE.v..a,;; .. --==--..!...~l4~~=-·._, -elcJ=-· ~-· ---,.--___,.. --· Govt. Contract No. _____________ _ ,-. Contractor. __ b;o __ 0....,,./~_°{2o __ CJV"Z.;---=-. _::r~:'c?i. __ _ I OSA or OSHPD #-------------- Other _____________________ _ INSPECTION _-OSHPD _OSA VfLtU:e::7) ..LSpecialty A,JGHL)fl5 .--Mechanical __ Electrical __ Roofing __ concrete £...:...Masonry __ Struct Steel __ Prestress Cone __ Pile Driving __ Fireproofing __ Waterproofing __ Non-Destructive __ Soils Technician __ . Batch Plant __ Bolt Pull-Out MAT'L SAMPLING - __ Concrete Cylinders __ Cement __ Mortar Samples ___ Grout Samples __ Masonry Prisms __ Masonry Block __ Fireproofing · __ Units (block or brick) __ Asphalt Concrete __ Roofing __ Reinf .. Steel __ Steel __ H.S. Bolts __ Tendon (PT Strands) _ ._Other __ Other ____ _ __ ._Other ____ _ ," ·aTY -M~TERIAb ~CJ.,1eN\'Zi ~PECTION CHECKLIST _. __ T R1nf.: Rebar ~'f-~ 1 'i;::n & Specs ______ 1 _ Rini.: W.W.F. ______ ~learances _ Rini.: Tendons ______ L.Jildsitions. ________ 1 _ Cone.: Mix #/psi _____ _L Sizes _______ _ ___ Cone.: Mix #/psi ______ Laps _______ _ ___ Cone.: Mix #/psi ______ Future Continuity #/psi, __ _ ___ Grout: Mix #/psi _ Consolidation _____ _ _'Mortar: Type/psi _ Mortar Batching ____ _ ___ Units: Block _ Electrode Storage _____ 1 ___ Units: Brick _ Torque Applied ____ _ ___ Steel -~ ____ H.S. Bolts ",/ ,ff~ { P.I "1...·,Z,.7'1 ----Metal Decking ~o C ~ , _____ Electrodes_______ 9:LV. ___ Fireproofing _____ _ ___ Other _________ Corrective action required __ ___________ Corrections completed ___ 1 CERTIFICATION OF COMPLIANCE: To the best of our kn9wledge;all of the rep ed Work, unless otherwise noted, substantially complies with approved plans, specifications and applicable sections of the building code~. This report covers the locations of the work inspected only and does not constitute engineering opin- ion or project control. INSPECTOR SIGNATURE---'-t--+--<----1------------- PSt-e-soo-110(2J CERT.No.___.__1Q_~----=--8-~ -- DAT~---'3-~{q ____ ;-O_~_(U:\A______....._~~ .. · I••~ iJ information ,~..,. :To Build On Eg,Jineering • Consulting • Testing WF.'. ~~ ;,;.,.;-'>A• t ....-inuw5~~e~ORf Page_1_of_ CLIENT:ffll. A /ZCK, /~, DATE_~i--_~ __ -_O_.L-,-__ 2 5 i002 ' . PROJECT (Name)~4c....=.S-'-l $-=------- (Address) I 8'1J ~,,J.h~ JU> C.81d.-b REPORT NO. C>S:k: tozP?... -t,S- Architect _ _,fi:_~_fS.~----,----"------------Building Permit No. _C.,..__,.d._o"-"-t =l--='I=l~:3-______ _ Plan File No, ________________ _ Engineer_-'---------------,-----,----,---Govt. Contract No. _______________ _ OSA or OSHPD #-------------- Contractor ___ ---'------------------Other ___________________ _ INSPECTION M~L SAMPLING 01 ~ATERIAL mTION INSPECTION c.i11us;;, ___ OSHPD· __ oncrete Cylinders Rinf.: Rebar ___ :fl) LPlan & Specs i1 -_ _OSA __ Cement _ Rinf.: W.W.F. { ,-,n ·v ---Clearances ~ r I ..._ __ Specialty · __ Mortar-Samples --_ Rinf.: Tendons Positions fivi'P/>~ __ Mechanical .--Grout Samples --~ Cone.: Mix #/psi ~6 Sizes M 'fl_..~ J( ·--. Electrical __ Masonry Prisms -. Cone.: Mix #/psi _ aps ll Plj -~ · f __ Roofing __ Masonry Block --_ Cone.: Mix #/psi _ Future Continuity #/psi *Concrete __ Fireproofing _·_ Grout: Mix #/psi --¥.-Consolidation _Masonry '_·_ Units (block or brick) ._· Mortar: Type/psi _ Mortar Batching __ Struct Steel __ Asphalt Concrete --· ___ Units, Block _ Electrode Storage __ Prestress Cone __ Roofing --_ Units: Brick _ Torque Applied __ Pile Driving . __ Reinf. Steel ---·_. Steel __ Fireproofing __ Steel --_H.S.Bolts __ Waterproofing __ H.S. Bolts _ Metal Decking __ Non-Destructive __ Tendon (PT Strands) --_ Electrodes __ .$oils Technician __ Other --_ Fireproofing. __ Batch Plant, __ Other --_Other .K.. Corrective action required~ __ Bolt Pull-Out . __ Other --_ Corrections completed REMARKS '~~ ~i ~ t;)er.J 7-A-#t~~ ~@(2t 1/J~ I I I CERTIFICATION OF COMPLIANCE: To the best of our knowledge, all of the reported work, unless otherwise noted, substantially complies with approved plans, specifications and.applicable sections of the building codes. This report covers the locations of the work inspected only and i;toes not constitute engineering opin- fon or project,control. INSPECTOR NAME 'R .. nl, ~~ CERT. NO.__::~::;;.:.·....:....::........,,Ac...::~~~o.::a.-1P""--ZB,=>,,,,,C'-------- (PrfntClea INSPECTOR SIGNATU~--.... --~-1/-----,,.,.:::::::;.c .. ~--...,~--DATE ___ /._~---°'---=--------- Psr-s-soo-110(2) _ __J l ;J Infonnation • ~To Build On Engineering •·Consulting • Testing Jl/Ji'ij.,"lf"~fi'i\l!7'f"t\ ~<!~oil--,&B \, w~-'_.)J ~-;-~-, CITY OF CAJID:TiTu ENG! EERING.J?.f:'f'!. ">1 :,: :::· !f_ REPORT OF CONCRETE COMPRESSION TEST TESTED FOR: JACKIE HOR ARCHTICTURE, INC. 9·444 FARNHAM ST., SUITE 300 SAN DIEGO, CA 92123 DATE: January 30, 2002 FIELD DATA: LOCATIONOFPLACEMENT EQUIPMENT PADS @ H & 1 DATE PLACED TIME SLUMP, IN. AIR CONTENT, % AIR TEMPERATURE, °F CONCRETE TEMPERATURE, °F DATE RECEIVED IN LAB FIELD DATA SUBMITTED BY MIX DATA SUBMITTED BY January 30, 2002 4 1/2 70 78 January 31, 2002 R. MOTSINGER PALOMAR TRANSIT MIX PROJECT: ISIS PHARMACUETICALS 1891 RUTHERFORD RD., CARLSBAD OUR REPORT NO.: 059-10202-14 SUPPLIER DELIVERYTICKET NO./TRUCK NO. MIX NUMBE.R AND PROPORTIONS CEMENT WATER FINE AGGREGATE COARSE AGGREGATE ADMIXTURE PALOMAR TRANSIT MIX 1237959 304009 TYPE II ~S.utt.E.SS.on£BWl~Cti~~NT· C231·97 (EXCLUDING SEC Ol· IEMl'ERAJVRE· CIQ!H:86(Q3)· CYLINDERS· C31·Q6 (EXCLUDING SEC 9 2 2)· SAMeJ.ING· C172-97 COMPRESSION TEST-RES UL TS ASTM C39-96; C1231-93 SPECIMEN TEST \ r TOTAL I CYLINDER I CYLINDER COMPRESSIVE LABORATORY IDENTIFICATION AGE DATE OF I LOAD I DIAMETER AREA STRENGTH NUMBER OR SET NO. (DAYS) TEST (LBS.) (IN.) , (SQ.IN.) (PSI) TYPE OF BREAK ! I ' 2084 A 7 02/06/02 130000 I 6.00 28.27 4600 Columnar I I I 20·94 B 28 02/27/02 j i I 2084 C :is 02/27/02 I I ! ' 2084 D I I I I l / : I ! i ! i I I I SPECIFICA TI_ONS 28 3000 REMARKS: X Cylinders made by PSI represenlative. X Cylinders picked up by PSI _ represenlative. Test results comply with applicable specificaUons. Cylinders made by Architect's or Contractol's represenlative. Cylinders delivered lo PSI laboratocy. Test results do not comply with applicable specifications. All cylinders capped in accordance with ASTM C617-94. cc: City of Carlsbad, Good and Robers, Tim Heinichen THESE TEST RESUI. TS "1'Pl Y ONLY TO THE SPEciFIC SAAIPlfS TESTED AICJ W. Y NOT BE INOICA TIVE OF THE ENTIRE CONCRETE PI.ACEMENT. 'lEPORTS W. Y NOT BE REPROOUCED. EXCEPT IN FULL. WITHOUT YmlTTEN PERMISSION BY PROFESSIOfW. SERV1CE INDUSTRIES. INC. Respectfully submitted, Professional Service Industries, Inc. Bodman, RCE Vice President 0S1 A-200-1 (S)F Professional Service Industries, Inc .• 6867 Nancy Ridge Drive, Sui!e E • San Diego, CA 92121 • Phone 858/455-0544 • Fax 858/455-1170 . [;' ·•1 lnfOrmation • .ToBuildOn Engineering • Consulting • Testing Page_1_of_ INSPECTION REPORT CLIENT tfii( AV?CiJ. l-1-2-07......, DATE-,--,-------'-------- Architect_~------,------------- Engineer }).t,v iµe Contractor _ ___,, _______________ _ INSPECTION MAT'L SAMPLING QTY _QSHPD _ Concrete Cylinders _QSA ___ Cement _Specialty ___ Mortar Samples -- _._ Mechanical _ Grout Samples -·- _ Electrical _ Masonry Prisms -- _Roofing _ Masonry Block -- _. _ Concrete ___ Fireproofing -- Masonry _ Units (block or brick) --Y Struct Steel _ Asphalt Concrete -- _. _ Prestress Cone _Roofing --· _ Pile Driving . _ Reinf. Steel -- _ Fireproofing ___ Steel _waterproofing _H.S.Bolts -- -Non-Destructive _tend6n·(PT Strands) _Soils Technician _Other -- _ Batch Plant _Other _ .. _ Bolt Pull-Out _Other REMARKS PROJECT (Name)._____,7=-=S=~=---S ____ _ (Addres-s-)•/B-.9{::k.~ cl ~ REPORT NO. <9s<J -tO'u:J 2.... -/ 3 Building Permit ~?3-L751"'3-~0 Plan File No. _______________ _ Govt. Contract No. --------------- OSA or OSHPD #-------------- Other __________________ _ MATERIAL DESCRIPTION INSPECTION~~ _ F.linf.: Bebar ~n&Specs _ Rinf.: W.W.F. __ Clearances _ Rinf.: Tendons _ Positions _ Cone.: Mix It/psi _Sizes _·_ Cone.: Mix lt/ps! _Laps _. Cone.: Mix It/psi _ Future Continuity It/psi _ Grout: Mix It/psi _ Consolidation _ Mortar: Type/psi _ Mortar Batching _ Units: Block ~Electrode Storage Ofl'f¼L, _ Units: Brick _ Torque llie~ r;J._steel A.3C. Dt '1J&~b I __ H.S. Bolts ~B~~¾-&o,Zj _ Metal Deckin·g .bl. Electrodes na. tB _ Firepro~!ai:; -~St"· ...... "' '<..corrective action required~ Pb::,Other-.,......,. -..... , - ,~ A0,~7,,.., "---;,-;;zp tt.,fhc. Corrections completed ., ·lwsf>~ fatl8. e>p~,w ~a~ . . . . . ?d/ . =- CERTIFICATION OF COMPLIANCE: To th~ best of our knowledge, all of !he r~ported work, unless otherwise noted, substantially complies with approved plans, specifications and applicable sections of the building codes. This report covers the locations of the work inspected only and does not constitute engineering opin- ion or project control. · INSPECTOR NAME< p_L ~::: INSPECTOR SIGNATURE---i}""'"/__._. _______ ____ CERT. NO. Shv Atlf?J 74'} 'DATE f-22..--$? PSl·B-900-170(2) l ;/ Information _ • .ToBuildOn Page_1_of_ Engineering • Consultim, • Testing INSPECTION REPORT CLIENT HD 2 JMA.eA7?c4,u:.J;tlL DATE /-/4'-0 2. Architect _______________ ---"------- Engineer _____ __, __________ --,--___ -- Contractor ttqc,J ;-(,p6,t'/s INSPECTION MAT'LSAMPLING QTY -_-OSHPD _ Concrete Cylinders -- -. OSA __ Cement --· __ specialty __ Mortar Samples __ Mechanical __ Grout Samples -- __ Electrical ___ Masonry Prisms --__ Roofing _ Masonry Block --__ concrete ___ Fireproofing __ Masonry __ Units (block or brick) __ Struct Steel _._ Asphalt Concrete -- __ Prestress Cone __ Roofing -- __ Pile Driving __ Rein!. Steel -- _--Fireproofing __ Steel --__ waterproofing __ H.S. Bolts -- __ Non-Destructive __ Tendon (PT Strands) ---X Soils Technician __ Other -- __ Batch Plant _Other, ---· __ Bolt Pull-Out __ Other --.. ·REMARKS P'ROJECT (Name) ::tS/J /J;1,-1rut:1vc/. ic.d& (Address) IMI &lla-6,./ U /41.sW o/ REPORT NO. cz5'C?-/@(?rz_ -/ I .Building Permit No. ______________ _ Plan File No, ________________ _ Govt. Contract No. ______________ _ OSAorOSHPD#-------------- Other ___________________ _ MATERIAL DESCRIPTION INSPECTION CHECKLIST _ Rini.: Rebar _ Plan & Specs _ Rinf.: W.W.F. _ Clearances _ Rinf.: Tendons _ Positions _. _ Cone.: Mix #/psi _Sizes _ Cone.: Mix #/psi _Laps _ Cone.: Mix #/psi _ Future Continuity #/psi _ Grout: Mix #/psi _ Consolidation _ Mortar: Type/psi _ Mortar Batching _ Units: Block _ Electrode Storage _ Units: Brick _ Torque Applied _Steel _H.S.Bolts _ Metal Decking _ Electrodes _ Fireproofing _Other _ Corrective action required __ _ Corrections completed .I' . / I /»ck I'd I e1 f ,?Jt14/, t/tYt'caL Aul. ..4cM C //4/ Mir h/4-kdJ s 6--cvn- . / /Jr·r /4/4, CERTIFICATION OF COMPLIANCE: To the best of our knowledge, all of the reported work, unless otherwise noted, substantially complies with approved plans, specifications and applicable sections of the-building codes. This report covers the locations of the work inspected only and does not constitute engineering opin- ion or project control. INSPECTOR NAME t111f; Ji/ye1l..--Sl11u~--- (Print Clearly) CERT. NO. _______________ _ INSPECTOR SlµNATURE ~4 ~ -~ PSI-B-900-170(2) DATE /-/1)-o '2-- l ii/ lnformatioYI ~ • .ToBuildOn Engineering • Consulting • Testing REPORT OF FIELD COMPACTION TESTS TESTED FOR: JACKIE PROJECT: ISIS PHARMACUETICALS HDR ARCHTICTURE, INC, 9444 FARNHAM ST., SUITE 300 SAN DIEGO, CA 92123 1891 RUTHERFORD RD., CARLSBAD DATE: fanu~ry ~o, 2002 ----.-... -__ .,. -... ---------·--------·--· --· -----· OUR REPORT NO.: 059-10202-11 • -• _., .. ---· -----.. ...., ____ ' ,M ... -.. • ._,. ·--· •-.-•• --,.,. __ , ____ ~ •••-·-·-· -n --•--·---·-·----··-·---·••• -• TESTDATA: (10) Red Brown Silty Sandy Sand PSI Lab# 02-005 OPT. MOIST. = 8.5% ,.. __ . ·-.. -----·-· .. ---,-~. --·--. --------··-------···-··---·--·--·,-·--· --· ...... . ,MAXIMUM . . i 1 1 I COMMENTS· I TEST I TEST NO. DEPTH 1 ELEVATION SOIL ID LAB DRY * WATER WET • · PERCENT Spec 9 5 % M' •.•. NUMBER ·-· DENSITY__ CONTENT--·-DENSITY !. DENSITY (.COMPACTION I •.•...•. ·-·---· _ l.n . I I ...... 10 ·--~~·9·~·0 7.3 133.9 124.8 I 96.7 :1 l ·---~1 ... ~-~~·,,·. ---· I -31 A I I 2 8. 0 11 -2' 10 129.0 __ 7:.? ..... 135_:!., .. ~~~~.-~_! --~~~-... !:. -A 3 8. 0 11 -18" 10 ! i I 134. 9 ! 124. 7 I 96. 7 11 -A 129.0 8.2 ····---·-. ···-·-....... -·---··--··---·---····-1-----·-·-1··---.. --· -·· 135.3 125.3 I 97.1 1 -A .. ----~---------------·· . --· -----·-' 4 8.0 11 -10 II 10 129.0 8.0 -·---t-~--------------·--·---·-·--·-· --··-------------- 5 10 .. 0" -8 II 10 129.0 ·10 .1 136.1 123.6 95.8 1 A . -··----------~-;----~-----.-------.. ---·-·-----------------,-----+-----t------- 6 1. 6. 0 11 -611 10 129.0 9.8 135.4 TEST LOCATION: MECHNICAL ROOM 1 15 1 WEST OF BUILDING ----------------------------------------------~------ 20 1 WEST OF BUILDING MIDDLE OF PAD 2 3 26 1 .WEST OF BUILDING NEXT TO EXISTING BUILDING 4 10 1 WEST OF BUI~DING 4.' FROM. RETAINING ~ALL· 5 6 I NOTES: TESTS PERFORMED PER ASTM D2922-96 & ASTM D3017-96 DENSITIES SHOWN: lbs. per cubic foot . WATER CONTENT: Percent of dry weight PERCENT COMPACTION: Based on maximum dry densi!)t obtained ori sample indicated by soil ID·number. * (10) ASTM D 1557-~l Procedure A *COMMENTS: 1. FILL "1ATERIAL 2. BAChFILL 3. BASE COURSE 4. SUBBASE 5. SOIL CEMENT 6. OTHER 123.3 95.6 1 -A A. TEST RESULTS COMPLY WITH SPECIFICATIONS 8. PERCENT COMPACTION DOES NOT COMPLY WITH SPECIFICATIONS C. RETEST OF PREVIOUS TEST D. MOISTURE IN EXCESS OF SPECIFICATIONS E. MOISTURE BELOW SPECIFICATIONS TEST INSTRUMENT: TROXLER, 17881 REMARKS: STANDARD COUNT M: 613 ADJUSTMENT DATA M: D: 2335 D: TECHNICIAN: CATHY PULVER-STONE cc: City of Carlsbad, Good and Robers, Tim Heinichen THESE TEST Rf SUI.. TS APPi. Y ON1. Y TO THE SPECIFIC LOCATIONS NOTED AND W. Y NOT REPRESENT ANY· OTHER LOCATIONS 011 ELEVATIONS. REPORTS W.Y NOT BE REPROOUCED. EXCEPT IN FULL. WITHOUT WRITTEN PERMISSION BY PROFESSIONAL SERVICE INDUSTRIES. INC, Respectfully submitted, Professional Service Industries, Inc. j},,t'C~- Da1e Bodman, RCE Vice President PSI A-100-2 (')F Professional Service Industries, Inc.• 6867 Nancy Ridge.Drive, Suit~ E • San Diego, CA 92121 • Phone 858/455-0544 • Fax 858/455-1170 l iiJ Information • .ToBuildOn Engineering • Consulting • Testing REPO.RT OF MOISTURE DENSITY RELATIONSHIP OF SOIL TESTED FOR: JACKIE PROJECT: ISIS PHARMACUETICALS DATE: 104 HDR ARCHTIC:TURE·, INC. 18 9l. RUTHERFORD RD.·, CARLSBAD 9444 FARN}w,t ST., SUITE 300 SAN DIEGO, CA 92123 -OUR REPORT.NO.; 059~10202-12 TEST DATA Visual Classification OLIVE GREEN SILTY CLAY PSI LAB# 02-005 Sample Source EXISTING SOIL Method ·of Test ASTM D 1557-91 PROCEDURE A Rammer: Mechanical Method of Preparation: Moist ..:1-:::.::.:-:-::::-1:..::: :::::::.:: :!:::t!-:-! ::-:.:.:-:::_: ::::::::.: ::;;::-:~: :::·;::~: ::::::,::: .. __ ..................... ··-····· .................... -................. . ···--·--·-.................. . ............... .. ---··· ......... . ............... ,.,._.._. ............... . ................ ............ ....... ... __ ....., __ ............. -········ Test Results Maximum Dry Density. Optimum Moisture Content 10 9. o lbs/ft~ 17 .o % ................. -·--:: . --··--·-· ~<-.... :-._:: ~ • -~ ~~ --~-~ ;?~ (estim\'lte) Grain Size Analysis (ASTM C136-96a and/or C117-95) Sieve Percent Size Passing 100 !!!':"!!.:::-:.:::-::.:::: ::::::::: •••••••• ·······-· ··--····· ···-····· .. ··-·-·--·· ----~ --._ .. _.:::! !:....rt ...... !! -:;-!:!:!"1---... 10 12 !4 16 18 20 22 24 MOISTURE CONTENT, PERCENT OF DRY WEIGHT REMARKS: Respectf!JIIY submitted, Professional Service Industries, Inc. cc: City of Carl$bad, Good and Robers, Tim Heinichen ~~ Dale Bodman, RCE REPORTS W.Y NOT Be REPROOUCED. EXCEPT IN FIAL. WITHOVT 'MUTTEN PERMISSION BY PROFESS!CfW. ~RVICE IIOJSTRIES. INC. Vice President •·100-1 (J)F Professional Service Industries, Inc.• 6867 Nancy Ridge Drive, Suite E • San Diego, CA 92121 • Phone 858/455-0544 • Fax 858/455·1170 l •/ Information M. • ®To Build On Engineering • Consulting • Testing REPORT OF CONCRETE COMPRESSION TEST TESTED FOR: DATE: FIELD DATA: JACKIE HDR ARCHTICTURE, INC. 9444 FARNHAM ST., SUI+E 300 SAN DIEGO, ~A 92123 November 16, 2001 LOCATION OF PLACEMENT LINE 1. 6 (F. 6) DATE PLACED TIME. SLUMP, IN, AIR CONTENT, % November 16, 2001 PROJECT: ISIS PHARMACUETICALS ( 1!391 RUTHERFORD.RD., CARLSBAD 13>1) OUR REPORT NO.: 059-10202-3 SUPPLIER DELIVERY TICKET NO./TRUCK NO. MIX NUMBER AND PROPORTIONS PALOMAR TRANS MIX 304010 .AIR TEMP!;RATURE, °F CONCRETE TEMPERATURE, °F DATE RECEIVED IN LAB November 19, 2001 CHRIS REEL PALOMAR TRANS .MIX CEMENT WATER FINE AGGREGATE COARSE AGGREGATE ADMIXTURE FIELD DATA SUBMITTED BY MIX DATA SU~MITTED BY IIOIE~PJ.Ic:AeLE.ASJM.SJANO.a.BDS,UNLESS.OTHERW!SEJNDLCA.TED~SLUMe;..Cj:t:J:.QZ;l,18-COW:El,IT;_C2.31:9L(EXCLUDltl(LSEC...6JJ.EMe.EBAilJBE:_C1QM,.8.6{Q3.l;_CYl.ltlDEBS.:..Qc.9JlJeXCI.UDJN.G_SEC-9.2.2J:..SAMe.LIN.G:J:.112:.aL COMPRESSION TEST RESULTS -I SPECIMEN TEST LABORATORY IDENTIFICATION AGE DATE OF NUMBER OR SET NO. (DAYS) TEST 4648 A 7 11/23/01 4648 B 28 12/14/01 4648 C 28 12/14/01 .,. SPECIFICATIONS 28 REMARKS: _K Cylinders made by PSI representative. Cylinders made by Ait:hitect's. or Contraclor's representative. ASTM C39-96; C1231-93 TOTAL CYLINDER LOAD DIAMETER (tBS.) , (IN.) 119000 6.00 Cylinders picked up by PSI _K. representative. Cylinders delivered-lo PSI laboratory. CYLINDER COMPRESSIVE AREA STRENGTH (SQ.IN.) (PSI) TYPE OF BREAK 28.27 4210 Cone 4000 Test results comply with applicable specifications. Test results do not comply with applicable specifications. All cylinders capped in accordance with ASTM C617-94. cc: City of Carlsbad, Good and Robers, Tim Heinichen THESE.TEST RESULTS APPLYONl:Y TO THE SPECIFIC SAMPLES TESTED ANO MAY NOT BE INDICATIVE Of THE ENTIRE CONCRETE PLACEMENT. REPORTS W. Y NOT BE REPRODUCED. EXCEPT IN FULL, WITHOUT WRITTEN PERMiSSION BY PROfESSlow.L SERVlCE INDUSTRIES, INC. Respectfully submitted, Professional Service Industries, Inc. ~&-L---- Dale Bodman, RCE Vice President PSI A-200-4 (6)F Professional Service Industries, Inc. • 6867 Nancy .Ridge Drive, Suite E • San Diego, CA 92121 • Phone 858/455-0544 • Fax 858/455-1170 , . l •J Information . • ®To Build On Engineering • Consulting • Testing REPORT OF MOISTURE DENSITY RELATIONSHIP OF SOIL TESTED FOR; JEFF GREER PROJECT: RESIDENCE DATE: 134 1-130 0 0 LI. (.) in :::, (.) 0::: 126 w a. en OJ ..:J ~ 122 en z w C ~ C 11'8 114 110 5 REMARKS: 2297 MIRA SOL 2294 MIRA SOL -VISTA VISTA, CA 92084 December 11, 2001 OUR REPORT NO.: 059-10209-1 + •.. ' 7 9 .. .. -~ '-f+ ' TEST DATA Visual Classification L;i.ght Brown Silt PSI Lab# 01-197 Sample Source Method ofTest ASTM D 1557-91 Rammer: Mechanical Method of Preparation: Moist Test Results Maximum Dry Density Optimum Moisture Content 119 . o lbs/ft~ 13 .0 % Atterberg Limits (ASTM 04318-98) LL: ---PL: ---Pl: ---SpecificGravity: 1.55 (estimate) • ••• Grain Size Analysis {ASTM C136-96a and/or C117-95) Sieve Percent Size Passing 11 13 15 17 19 MOISTURE CONTENT, ·Pl;RCENT OF DRY WEIGHT Respectfully submitted, Professional Service Industries, Inc. cc: City of Vista ~~ Dale B. Bodman, RCE REPORTS MAY NOJ BE REPROOUCEO. EXCEPT IN FULL. WITHOUT WRITTEN PERMISSION BY MOFESSIONAL SERVICE INDUSTRIES, INC. Vice President A-100-1 (3)F Professional Service Industries, Inc. • 6867 Nancy Ridge Drive, Suite E • San Diego, CA 92121 • Phone 858/455-0544 • Fax 858/455-1170 l .. •1 Information • .ToBuildOn Engineering • Consulting • 'n!sting REPORT OF MOISTURE DENSiTY RELATIONSHIP OF SOIL TESTED FOR: JACKIE PROJECT: ISIS PHARMACUETICALS DAIE: 144 ti~14Q 0 ~· LL (.) iii :::, (.) ct: 136 w 0.. Cl) al ..J ~ 13_2 en z w C >-ct: C 128 124 120 2 HDR ARCHTICTURE, INC. 1891 RUTHERFORD RD., CARLSBAD 9444 FARNHAM ST., SUITE 300 SAN DIEGO, CA 92123 ___ ja,11.m1.ry _ 10, 2002 ... . :t:t±t - .. .. ~-· 4 6. ' -·-, I-•-'· 4; • _, + _!, ,-;·, ~ OUR REPORT NO.: 059-10202-10 TEST DATA Visual Classification Red Brown Silty Sandy Sand PSI Lab# 02-005 S~mple Source Import Method of Test ASTM D 1557-91 Procedure A Rammer: Mechanical Method of Preparation: Moist Test Results Maximum Dry Density Optimum Moisture Content 12 9 . o lbs/ft~ 8.5 % ----•:.Atterberg ,l;.in,its··, (ASTMp~1a-eaJ LL: ---Pl:-_-__ Pl: ---"'Specific Gravity: 2.50 (estimate) -f"",&.- 8 10 12 14 MOISTURE CONTENT,.PERC~NT 9F, D.~Y WEIGHT •• ~ ~ J -; ~ t . ~. • •• 16 Grain Size Analysis (ASTM C136-96a and/or C117-95) Sieve Percent Size Passing Respectfully submitted, Professional Service Industries, Inc. cc: city of Carlsb~d,-Good and Robers, Tim Heinichen A~~ Dale Bodman, RCE REPORTS MAY NOT BE REPROOUCED. EXCEPT IN FUll. WITHOUT WRITTEN PERMISSION"BY PROFESSIONAi. SERVlCE INDUSTRIES, INC. Vice President A-100-1 (3)F Professional Service Industries, Inc.• 6867 Nancy Ridge Drive, Suite E • San Diego, CA 92121 • Phone ~58/455-0544 • Fax 858/455-1170 Thursday, Janua,y 17, 2002 8:3·8 AM Mike Devine 858-7 48-6011 p.06 DEVINE ENGINEERING, INC. 12316 Ol!lk Knoll Rd~, Suite C Poway, CA 92064 (858) 748-6168 JOB r Br s c !J /!; tCt[.03 SHEET NO. Sy: -s-OF---- CALCULATED BY ______ OA~----- CHECKEDBY~--------OATE,----- SCALE ·::·:: ._ .. l D ~, 0 I -I ' .,.·::. ... · ~":~: j D ol :o-· .. ;,'JQ( -.. = )' . l ~. :--, t ¥ ' .. .....---..... ... \ ; ,a .. =:~ ... • ,#'-.! ·, . ·., .. ! .. i· .. I ! i---------: I . I I I l I I I I I . : . L·ZH·· -. ., .. '!t L-.:'-.,._ \ i:::L %·· · · , _ ·• •1,,· ~,'" : 1 ~:;:::f :•:• :•::;:i::c;,zi~:=;::::-:::-:;:::;-::===.i:~=; t: I • . I! . -:l CM··) (0-9) (E) (~} l. ·,i 1 Ar.~ '(IN n!n1n~~t'~ ~DH ~Jlf~l:nt rno1 ·v! wr ----·--·-----------· --·------ Thursday, January 17, 2002 8:38 AM DEVINE ENGINEERING, INC, 12316 Oak Knoll Rd., Suite C- Poway, CA 92064 (858) 748-6168 WAl...L 6?.Ac. \,-J(."'t. ?1:?--cs;-,c. -o I TIP . [@ -----~- ~-1--::~ J -- \ S\ ~ \'o\S' L l R~ ~ 'Clill --------- Mike Devine 858-748-6011 p.05 JOB fB[( L~h si,mNO. sx-Y OF'------- CALCULATEOBY' ________ O,_TE------- CHECKeilBY'---------OA1'E------- SCALE N ri1- •:,·.• ····· --. .............. ...,. ·:. ~, 'il: , ... ., ' • ( · .. -'t'·,· . ~:·-·--ti . . ·.,:_:;_.:i_·:_·.~.\;: F -:-····----i-r--T- .,. ·-... "., ·1-nr •. --____ "-,. __ l-----1... .. - " . .. ,, l ... _,, .. :"--:-.~t ... J •••. ~ 0 ......... , ~ . --,·-,r--·-~---- "' ' • ' ., • ,. ... . . • ,. :f"'-0!. ....... r ... "1~..,,·--··-\: ~ ........... I I 1 -··--- N •'-'4----N .. •"··--,__ ---··· ( ...... _.~.,OIi . ... ·-··•----,-· CJ •••• _ ~-......,1:i ·-· -~ •. l.~ .. 1~,io,-• ,._,,.,i_--~ i':i"····-. o 1:i :. • ~-,~-=-r ;. ·.,-. __ ... , ....... '-~ ·----~-... ,_ .. _ -..J--1.---1--. ... _____ ., . J_,.,.,.. .. • Jl,······ ti ._ ___ ___ fl .,..-1:'i __ ... ----·--···· ... - r-i--r-i---· : --::r \~" ~-1 .• _i __ J :-~. '.:;.{.;:.;.:~.:('~; ,;..:.:.:..l ,..__..._J-l.--•---.- : ... :~ . . . Thursday, January 17, 2002 8:38 AM ' N ·' <" (\/ DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd., Suite C Poway, CA 92064 (858) 748,6168 ___ ,.,:. ____ ,, -~-'--~ .... ': ~~ -~· . ~-".:.:·-·; .~ ...... · . .: .-~::. . · ... . . . . · :. ·. . Mike Devine 858-748-6011 p.07 JOS rers Lnf) SI-ET NO _! )(. ~ ' o; ______ _ CALCULATE08V ________ DATE _____ _ CHECKEOBY ___________ DATE _____ _ SCALE· .. '• :;, ... .............. ~ • .. '\ . •' -.. · .. •.,· ..... ····:,,, ·,•: •. :, . . ,. • ..... ,, ·:i·, , ... . ;:·; . ...... ····· ,1,·:.·:-: I ... ,· ,· ' ! i i ' Thursday, January 17, 2002 8:38 AM DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd., Suite C · Poway, CA 92064 {858) 748-6168 r' o.1) . ~ - ,~, \,()P,!I greil ·~, r~tl I SK-·f ( ryp 1 ... '"' tn t (ti - ' 0 l ~ Mike Dev[ne 858-748-6011 p.08 JOB f 13r s LIJD I CfS, {/3 SHEET NO. s )( -] OF·--- CALOULATEDBY----· __ DAiE _____ _ CHECKEDBY _______ DATE _____ _ -· ... ,, ... ~-,' ...... ---------j ( I I I v -----... --.. ~ ·~ I I ---------~ :::::;.:s:d:----l-}: I . t ·::;:.-. ' i·;r -+-------f I l ' I * >rn2s,c___,L__ r - I 1.: r .. ! I 1 ·.- '"'·-~-ww•'" •• · rt>-5 zru_C Ii ~(,c.A--C.S ~c.~rrt- . .. --· .. -·· ., ' ·-=--·----· ..... ·11•· !·· Thursday, January 17, 2002 8:38 AM DEVINE ENGINEERING, INC. 12316 Oak KnoU Rd., Suite C Poway, CA 92064 (858} 748-6168 I ~rs I iJ s L fl rr ----S'~-0 Mike Devine 858-7 48-601 "i p.09 JOB I BE 5 '-f) f> /'1( 03 SHEErNO. s '{. -s--01'·-- CA~CULAlEPBV _______ DATE ____ _ CHECKEDBY-------DATE ____ _ W~H-Ol ~OOl 'vl 'NVf ---· ·--- 12/19/01 WED 15:35 FAX 760 598 6801 GOOD & ROBERTS -... DEVC:;19-2001 WED 03: 18 PM CITY OF CARSLBAD FAX NO. 760 602 8558 Carlsbad 01-3313 November l, 2001 SPECIAL INSPECTION PROGRAM ADDRESS OR LEGAL DESCRIPTION: lli:l ( (ZL\~d 2:cJ __ PLAN CHECK NUMBE~: 01-3313 --· OWNER'S NAME: ! S:..\ S:,.. P'1e,lwt • 14)002 p, 02 I, as the owner, or agent of the owner (contractors may not employ the special inspector), . certify that 11 or the architect/enginoor of rscord, will be responsible for employing the :special inspector(s) as required by Uniform Building Code (UBC) Section 1701.1 fprthe construction project loca t the site llstod Qbove. UBO Seotion 106.3.5. · I. as the engineer/architect of record, certify that I have prepared the following special inspection ·program as required by UBC Sect1011 106 . .3.5 for Lhe construction project located at the site listed above. I • ••• <'\6"AR. 1. List of ~ork req~fring special Inspection; D Soils Compliance Prior to Foundation Inspection 0 Structural ConcrAta Over 2500 PSI, B Prestressed Concrete Structural Mason_ry . . , . . D Designer Specified / <,\'\s .~) '•Goal / r;;_,v .. ~r,.igiie•i;l°(~ f -::} ~~'" • l'o. ~ } "' ~:,A . · J8lt=iefd Welding · ~igh Strength Bolting r:J t:xpansion/Epoxy Anchors · D Sprayod-On Fireproofing D Other . . 2 •. N~me(~) of lndJvldual(s) or flrm(s) responslbla for the special Inspections fisted abova: A. ___,.J),_. _f'.r,._.<.__· -~~.,.,.._..,...-_.....___ _______ _____ : . .,, 11; ' ••• , •• ·.•:··.r 8, _________ . __ .. _:..,.,._,;j,:r ... ·:_ ... _.,__~!.;...~·.=·: .. ._· ..;,;!•~·--···.,.'.;..' _. ___ ......., _ __._, ________ _ c. ---------------------------------- 3. Duties of the special Inspectors for the. work listed above: A. B. C. ----------------'------------------"'' Spacial Inspectors shall check In with the City and present their credentlals for approval ~ beginning work on the Job site. : . . • .: ~ •. i, ' • . ·:·· -~T'S.·I. SPECIAL INSPECTION REPORT JOB START: JOB STOP: CB 013113 PLAN FILE #: ___ _ TYPE OF OBSERVATIONS: MASONRY_ REINFORCED CONCRETEK FIELD WELDING_ EPOXY_ SAMPLES: NUMBER: J TYPE: ~.....:.=-:c..=.<..:==-+-~--=-J~-+-=--,~---~-,-----+-- Materials/Design MiX NLJmbets/PSI: _ -~~~~~~LIIL:L_.____.:.......;__:::::_,,....:..-....,~-'---<------""""'-~=.:.._::=---- lnspecto(s Signature ~J, IrifOrmation , · --../o~..:J .To Build On )t,-,., ple w-f'&/); d t:M-e =ef/_ Page_1 ot ~ · Engineering• Consulting• Testing INSPECTION REPORT /f IS /.4:/:; 5 /;-ttc /'-'""41/ re 7 ~ / .,-,, ~ ~-;r .5.L( PROJECT (Name) /4,(e~~G?/? /"fC CLIENT!:_../+L.-->-...J""--.,_/ (._.,,~---'--y---'-~ &fir S/? I ~/ /4/2~ p/(UJ_ _) ~ . e -..1a.f (Address)22S~~~/ DATE Ou =• (', fc /Id:£ te.JS 'Af G,.,.., dal1:'IU C--::( I ti Q-( 1<.u//J ~(11 REPORT NO 'Y>9 -i O ~o~ -S 9' u ~ 7 Architect ff/) ~ ~d qBuilding Permit No.Ci:::c.--=~'-'"d5c:,..L...1./c..c,. 3~1.-'-/._(3 _____ _ _......,/),__·e_cJ_c.._L)_A _ __,_ _____ C/.=-'.<,-~-~ Plan File No Is.£ 6s 9 -l(P 2£ 2 Engineer.__,_ __ -----'-,'---''-~--'-------...,....a...---Govt. Contract No.------~---,,''----- Contractor. ~ V sl~c INSPECTION ~ _QSHPD~ _OSA MAT'LSAMPLING _ Concrete Cylinders --i+---++-..., __ Cement _ Specialty I _ Mortar Samples • _Grout Samples _ Electrical _Roofing _ Concrete ·-. _ Masonry Prisms I . -. _ Masonry Block ___ ...___....,_.,. __ Fireproofing _Ma¥J~ ~ _Mtn'.idste C _ Prestress Cone , _ Pile Driving I( '_Fireproofing 'J:; A _waterproofing _ Non-Destructive _ Soils Technician :-Batch Plant _ Bolt Pull-Out REMARKS _ Units (block or brick) _ Asphalt Concrete -;---':"~~f!!)ff ~inf. tteel . _Steel -. _ H.S. Bolts _Tendon (PT Strands) _Other _Other ___ _ _ Other ___ ~ OSA o[8SHPD Jl.= Other · ;JI ;A/Jr.I Mb'\. QTY MATERIAL DESCRIPTION NSPECTION 9J-!EilyLIST __ ·-·-Rinf.: Rebar ________ Plan & Specfi,/l~ f f:>/V'()Y" ____ Rinf.: W.W.F. _ Clearances _ _..:.. ___ _ ____ Rinf.: Tendons _ Positions _____ _ ____ Cone.: Mix #/psi _ Sizes ± ____ Cone.: Mix #/psi _ Laps_~.....,,..__.,_, ____ _ ____ Cone.: Mix #/psi _ Future Continuity #/psi. __ _ ____ Grout: Mix #/psi _ Consolidation ____ _ ____ Mortar: Type/psi _ Mortar Batching ____ _ ____ Units: Block _ Electrode Storage ___ _ ____ Units: Brick _ Torque Applied _____ , ____ Steel, ______ _ ____ H.S. Bolts _____ _ ____ Metal Deckin:.:,,-...,._'C"T".,=,,\7-~ ____ Electrodes~4--___)...;.c;..J<.....:.,_,L. -. __ Fireproofing _____ _ ____ Other _ Corrective action requirect&t? --'---------__ Corrections completed __ _ 2.c;oS',£ t:t-c:fdt'-1 /!:,'1 loc:t PUuco (b-v, er bet, '(di,,_,,. .,. .f k-1 ~~ IJ~e lcfl-# -/Y't:l-1 :S-/4 . ~ al lrJ-3 '5/.3ap/ /r-21-3/ S.s.o (-eerlr' ,·~d, ca(Jqh~~e½r-{ AiJ//JG s/~I 5~ec/°a,//J.A-C~c>fr l)J ed_ l Lr 1/e.!J IP f o t1f>VJf:t!S /4_1Jre /' .'ieclt 1.-; .2. 2./s 1,,/ ' CERTIFICATiON OF COMPLIANCE: To the best of our knowledge, II of the reported work,.unless otherwise noted, substantially complies with approved plans, specificat(ons anp applicable sections of the building codes. This re~ort cove~s the locations otJt1e work inspected only and does not constitute engineering opin- ion or pro1ect control~ /2 ~ -t ff,uc jv.-l'a( ~.,?-4@e/' o;-cpa1e..~ 2([3,.G 1NsPECToR NAME Car(tdvtlut-f l Y cERT. No'.X;......;A:.....::~;...=:;a..;;...:~c.c.....~-_,,__~-;;:;;ad:_-____ _ ;~~,';!~~,R s10NATURE C,12,r(?:S¥4 DATE 2 / R0u IP I { Cue ) . Ill.Si/ InfOf1;UZtion .,,,.., , · .To Build On Page_1_of_ Engineering • Consulting • Testing INSPECTION REPORT /.5/.J ~#~£1>1/ttEtf T/~/JL.f CLIENr8flll;JtSn=;-e4 DATE /2 .,3 -'{)/ Architect_/i~'/J-~----,---------- Engineer ___ ~=--~---v;~/'"""". bf_t:-_______ _ Contractor.~ fA11m,'7.:f /(MJ 7 INSPECTION MAT'LSAMPLING __ QSHPD __ Concrete Cylinders _QSA __ Cement _Specialty _ Mortar Samples _Mechanical _ Grout Samples _ Electrical _· Masonry Prisms _Roofing _ Masonry Block _Concrete _ Fireproofing _Masonry _ Units (block or brick} ~Struct Steel _ Asphalt Concrete __ Prestrei;s Cone _Roofing __ Pile Driving _ Reirif. Steel __ _ Fireproofing _Steel _ waterproofing J{H.S. Bolts _ Non-Destructive _Tendon (PT Strands} _soils Technician _Other 1 _ Batch Plant _Other _ Bolt Pull-Out _Other REMARKS ;1/4 /)J~E~?W~ QTY -- -- -- .. -·- -- -- -·- .s_ -·- -- --· PROJEtT2f t:rne)LAB /J1 £22,4,,J/,Je (Address) /3f//?u7Jt&%;6'IJ &2J (/;:J@,184:2 ( fl4 J REPORT NO. 0 )1 --IO~ a_ -cj Building Permit No. __ C~' t) __ f2i_'/3-~/,~1/3-____ ' __ Plan File No, ________________ _ Govt. Contract No. ______________ _ OSAorOSHPD#-------------- Other ___________________ _ MATERIAL DESCRIPTION INSPECTION CHECKLIST ....c....=.. Rinf.: Rebar. _ Plan & Specs _ Rini.: W.W.F. _ Clearances _ Rini.: Tendons _ Positions _ Cone.: Mix #/psi _Sizes _ Cone.: Mix #/psi _Laps _ Cone.: Mix #/psi _ Future Continuity #/psi _ Grout: Mix #/psi _ Consolidation _ Mortar: Type/psi _ Mortar Batching _ Units: Block _ Electrode Storage XUnits;n~ _ Torque Applied Steel ?: ·/J5t);;./J T' _H.S.Bolts _ Metal Decking _ Electrodes __ Fireproofing _. _Other _ Corrective action required __ _ Corrections completed CERTIFICATION OF COMPLIANCE: To the best of our knowledge, all of the reported work, unless otherwise noted, substantially complies with approved plans, . specifications and applicable sections of the building codes. This report covers the locations of the work inspected only and does not constitute engineering opin- ion-or project control. INSPECTORNAME J., M~P ~l?'~! INSPECTOR SIGNATURE_· --1:--t~~p;,e-~---""--='-r:J!!I"""-=-------- ps1-s-soo-110(2) CERT. NO. 6 @f DATE_.:._/..:;._2__,/3=-=---~~{J-+-,I _____ .;..__ C~J In:JOrmatic _ • .To Build·On; · Engineering • Consulting • Testing cuENT ~ C&) ~--re{~ DATE lf/ 3-t> /~ [ I . JENN \F~ Lc:wl S Architect ___ ~-------'-----'------- Engineer_~D~G_V_I_N_c_. _6_N_b_. _____ _ Contractor_--'-'(0""60:..~ ...... D~_ .-'--M..___._,/J_.,:....c1Y).....,fRfJ2_.,;-= "-'-""-1(.._ __ $ __ '-- / 1NSP~?~ON MAT'L SAMPLING QTY i·--0;:,r, D __ Ccncre:e Cylinders ,_osA _Cement --I · ___ Specialty _ Mortar Samples -- I ·---·· Mecharncal _ Grout Samples --I ! ···--Eleetric.il _ Masonry Prisms -- ___ Fiooling __ Masonry Block -· -. -i ___ Concrete _ Fireproofing I -- i --·· Masonry __ Units (block or brick) -- I -'f-Struct Steel _ Asphalt Concrete ' . j ·-Prestress Cone _Roofing -- ___ Pile Driving _ Reinf. Steel _ Fireproofing +steel -- _ Waterproofing ___ H.S. Bolts -·- __ Non-Destructive _Tendon (PT Strands). 1 ··-·-Sc.us Tecnnrcian _Other -- i --· Batch Plant -Other -- ___ Bolt Pull-Out _Other -- REMARKS '• "'': :·, : . Page.a.Lot_ . " ..... ~ ... , .. . PROJECT (Name) I SIS ;fl)~ LA~ I 01 s r1-tce4Pc;.vrtc.. s (Address) ~1IT:l~E&!QV)~£/.) . avz_i.,s6,-\0 C.4 9'2.ao~ REPORT NO. D '5'1-/ 0 ~~ Building Permit No. ~@-~':o:/~-1-b!> --& Plan File No, _______________ _ Govt. Contract No. _____________ _ OSAorOSHPD#------------- Other _____________________ _ MATERIAL DESCRIPTION INSPECTION CHECKLIST _ Rini.: Rebar _ Pl.in & Sp,:;cs __________ _ Rini.: W.W.F. _ Clearances _ Rinf.: Tendons _ Positions _ Cone.: Mix II/psi _ Sizes _.Cone.: Mix II/psi _ Laps _ Cone.: Mix It/psi _ Future Cont,m,ity u:ps, _ Grout: Mix II/psi _ Consolidation _ Mortar: Type/psi _ Mor1ar Batct11ng _ Units: Block _ ElectrodG Storage _ Units: Brick. _ Torque Applied _SteelA'(tfZ '2t. 50. 1 f}-3tz _H.S.Bolts _ Metal Decking ·_ Electrodes ~fz OJo~~,UJ) _ Fireproofing _Other _ Corrective action required __ _ Corrections completi;d -~~_(:,: DfJf.erl..vrAJ 61:\:0P w~D(AJ(;. ,AT CMj ST&~L pgBV'lt cATICNU J..-OcATc-() AT ZTT Sovrrf i,~T. ':A>J ~c.os , ~lSo/t(!ci) ' ____ f ........ rruP ANO WwOcN(:;. DE wF r?:oof (;~AMS_ L,t)(:1,rrci) (5~.o) &6:Z'ZANrN£ k6/&L--1 P;t7vJffN UNG. (-P-H) ,rlfo (1-)) Authorized Signature~ CMJ -: :EATIFICATION OF COMPLIANCE: To the best of our knowledge, II of the reported work, unless otherwise noted, substantially complies with approved plans, ;pecifications and applicable sections of the building codes. Thi~ report covers the locations of the work inspected only and does not constitute engineenng opin- on or project control. u-J-v . 57 t,.J-'/ €0 crtY .±1-8, l, CERT. NO._-'------------------ DATE ___ ----.\1 __ ( 3_.U-,.../_o ] __ '11J_IM_c~: ~]_-~J_ I I l i/ Information ~ • .ToBuildOn Engineering • Consulting • Testing REPORT OF CONCRETE COMPRESSION TEST TESTED FOR: JACKIE HDR ARCHTICTURE, INC. PROJECT: ISIS PHARMACUETICALS 1'8-9,1-R:U!I!HE:RBQ~ . , CARLSBAD DATE: FIELD DATA: 9444 FARNHAM ST., SUITE 300 SAN DIEGO, CA 92123 November 16, 2001 LOCATION OF PLACEMENT LINE 1. 6 (F. 6) REVISION #1 OUR REPORT NO.: 059-10202-3 DATE PLACED TIME SLUMP, IN. November 16, 2001 SUPPLIER DELIVERY TICKET NO./TRUCK NO. MIX NUMBER AND PROPORTIONS PALOMAR TRANS MIX 304010 AIR CONTENT, % AIR TEMPERATURE, °F CONCRETE TEMPERATURE, °F DATE RECEIVED IN LAB FIELD DATA SUBMITTED BY MIX DATASUBMITTED BY N9vember 19, 2001 CHRIS REEL PALOMAR TRANS MIX CEMENT WATER FINE AGGREGATE COARSE AGGREGATE ADMIXTURE NOTE: APPLlcABLE ASTM STANOAAOS.UNLESS OTHERWISE INOICATEO.SLUMP. Ct4H7:AIR.CONTENT.C2Jt·97. (EXCLUOIN<LSEC. 01. TEMPERATURE: CI00-4-80(9Jl: CYLINOERS. CJ 1·90 (EXCLUOING SEC. 9.2.2). SAMPLING: Ct 72·97 LABORATORY NUMBER 4648 4648 4648 SPECIF!~ TIONS REMARKS: COMPRESSION TEST RES UL TS I SPECIMEN TEST I IDENTIFICATION, AGE 1 OR SET NO. j ~~~:_~ j A B C i j 7 i 28 : 28 ! I I I i , ---.. i' I 28 : DATE OF :TE~T ·- 11/23/01 12/14/01 12/14/01 - K Cylinders made by PSI represenlative. Cylinders made by Archilect's or Contraclor's represenlalive. · ASTM C39-96; C1231·93 I TOTAL CYLINDER LOAD DIAMETER (LBS.) (IN.) ---· I 119000 ! I 161000 l i I 155000 ! I i I ! ! ' ; I ! I I i ' I i i X Cylinders pic~ed up by PSI _ represenlalive. 6. 0.0 6.00 6.00 Cylinders delivered to PSI laboratory. ! i ! ! I l ; .!. -·-. ------ CYLINDER COMPRESSIVE AREA STRENGTH (SQ.IN.) (PSI) TYPE OF BREAK -----·-·---------------·-----· - 28.27 4210 Cone 28.27 5700 Cone 28.27 5480 Cone X I 4000 Test results comply wilh applicable specifications. Test resulls do nol comply with appiicable spec,flcations. & Shea & Spli ------ r t All cylinders capped in accordance with ASTM C617-94. Respectfully submitted, Professional Service Industries, Inc. cc: City of Carlsbad, Good and Robers, Tim Heinichen TliESE TEST RESULTS APPi. YON\. Y TO THE·SPECIFIC SAMPLES TESTED ANO MAY NOT BE INOICJ.TIVE OF ll-E ENTIRE CONCRETE PLACEMENT. REPORTS MAY NOT BE REPROOUCEO. EXCEPT IN FULL. WITHOUT WRITTEN PERMISSION BY PROFESSIOfW. SERVICE INDUSTRIES. INC. PSI A•200-4 (8)F Professional Service Industries, Inc.• 6867 Nancy Ridge Drive, Suite E • San Diego, CA 92121 • Phone 858/455-0544 • Fax 858/455-1170 f •,.~·•J1nf0rmation "' ,~..,• .To Build On Page_1_of_ Engineering • Consulting • Testing INSPECTION REPORT CLIENT ~)>~ ~',J-) IJJC, DATE (L-i :kn Architect ________ ----,'----~'--------- Engineer j)E\)/Ne._, Contractor. __________________ -'- INSPECTION · MAT'L SAMPLING QTY __ OSHPD __ Concrete Cylinders --__ OSA __ Cement -- __ Specialty __ . Mortar Samples -- _ Mechanical __ Grout Samples -- _ Electrical __ Masonry Prisms __ Roofing __ Masonry Block -- __ Concrete __ Fireproofing --__ Masonry __ Units (block or brick) _ Struct Steel __ Asphalt Concrete .-- __ Prestress Cone __ Roofing -- __ Pile Driving __ Rein!. Steel -- __ Fireproofing __ Steel ___ Waterproofing __ H.S. Bolts __ Non-Destructive __ T(mdon (PT Strands) -- __ Soils Technician __ Other --·- __ Batch Plant __ Other __ Bolt Pull-Out __ Other REMARKS PROJECT (Name)~/_S_l_S _____ _ (Address) 1891 &>/Ju,,~~ ~ ;J Al::> REPORT NO. 0-4':i-LQ2.0 2.. -7' ' Building Permit No. __ ,_;2-· __ /_,_/-=.>'---_______ _ Plan File No. ________________ _ Govt. Contract No.--------------- OSA or OSHPD #-------------- Other __________________ _ MATERIAL DESCRIPTION INSPECTION~~ ~ Rini.: Rebar-_J(plan & Specs · · _ Rini.: W.W.F. _ Clearances _ Rini.: Tendons _ Positions _ Cone.: Mix #/psi _Sizes _ Cone.: Mix #/psi _Laps _ Cone.: Mix #/psi _ Future Continuity #/psi _. _ Grout: Mix #/psi _ Consolidation _ Mortar: Type/psi _ Mortar Batching _. _ Units: Block _ Electrode Storage _ Units: Brick _ Torque App~ _Steel D(i1kJMJ, ~ I _H.S.Bolts _ Metal Decking _. Electrodes _. Fireproofing ..JL.other ~A_, C"""/)S6Ju _}(_ Corrective action required l:!!li. . J., I" M 6"2.."2'i .. , .ii:.tJJJ 02/l\:l Corrections completed ., 1.~ IWof-Y ~b-Jetls bl. J1A.e...2,L..c tJN &t-LB-I a:J opJ CERTIFICATION OF-COMPLIANCE: To the best of our knowledge, all of the·reported work, unless otherwise noted, substantially complies with approved plans, specifications and applicable sections of the building codes. This report covers the locations of the work inspected only and does not constitute engineering opin- ion or project control. INSPECTOR NAME _...:....fl~_mn--'=_6""""n...._t /.--~----i--e/1._---- INSPECTOR SIGN~~---- PSI-B-900-170(2) CERT. No.__,.S=-~---=l\'--~-f:,-'j;)'-----,,12-Z ..... ~~--- ·oATE---=--L _2_~_9 ____ .-e--'-/ _____ _ JW.,";;;'iiJ lnjOrmation " ,~..,, •. To Build On Page_1_of_ Engineering • Consulting • Testing INSPECTION REPORT · CLIENT ~ft/_,, Aka'J~~( DATE I . ~. 2'~.:z... -. PROJECT (Name) ~IOI\( ~ · (Address) 3q s3'1 ~12J.¼e.,T I J 11J .t5Adi.()lfd66 r Architect_C~A~l+--'tJD~U~tJ.:t=..........:·~...,...., ~'---'=--~~L-:::.,___• - Engineer_,_;tt_..,,ttl--=----...,r;;..~~--·#--411/t~&Jll:..L-_ ~------- Contractor_/:A~f£~· "'--L--"4~'tJ1e--,__,.._S:c...&-l<eJZd_. __ ,_ . ( REPORl NO. ? '5-ff-)-OC?~ .-L Build~.-e ~ 7:.,,,,c:) I Plan File No. llf~t/32?Jf · Z:, I INSPECTION _OSHPD _OSA _Specialty _ · _ Mechanical _ Electrical _Roofing I-· Concrete -. Masonry l _ Struct Steel . _ Prestress Cone ·_ Pile Driving _._Fireproofing -. _Waterp'roofing -. Non-Destructive -. Soils Technician _ Batch Plant -. Bolt Pull-Out INSPECTOR SIGNATURE PSI-B-900-170(2) MAT'LSAMPLING .-Concrete-Cylinders· - _._Cement _ Mortar Samples _. _Grout Samples _. Masonry Prisms ._ Masonry Block -.-Fireproofing .-Units (block or brick) ·-. _Asphalt Concrete _Roofing _ Reinf. Steel -. _Steel _H.S.Bolts __ Tendon (PT Strands} _Other _ Other ___ ~ _ _ Other ____ _ Govt. Contract No.--------------- OSA or OSHPD #-------------- Other ___________________ _ _o_~_v: _MR~;:~:::r_o_~_s_c_R_1P_T_1o_N__ ~~~:~~~ CHECKLIST -. _ ·_ Rini.: W.W.F. _ Clearances · ____ Rini.: Tendons -/4sitions ______ _ . ____ Cone.: Mix #/psi _L'Sizes _______ _ ____ Cone.: Mix #/psi _ Laps _______ _ __ . _ Cone.: Mix #/psi · _ Future Continuity #/psi __ _ ____ Grout: Mix #/psi _ Consolidation _____ _ ____ Mortar: Type/psi _ Mortar Batching _____ , ____ Units: Block _ Electrode Storage ___ _ _____ Units: Brick______ Torque Applied ____ _ ==-· ·=-;::s:.,g. -~~ ---=-u-:ii_,.~~,-..... ~ (. l :;,"'~~;.i~~;;_;~:...i __ Correctivra'ct~ required __ -=ir"-,..,_'-'"-~,_..._,._,_ ___ Corrections completed __ _ J Si. -/ O~:).._-c: F'ROM : PEG GR l FF' ITH o? S·. I. SPECIAL INSPECTION REPORT J08 STAAi: _____ _ JOB STOP: PlAN FILE i, · ___ _ lYPE OF OBSEflVATIONS: MASON~Y.._ 11EINFORCED CONCRETeK FIELD WSLOING_ EPOX"'_ P~ESTRESSED CONCReTe_ SHOP WE;LDIN<;t_ BOLTING_ REINFORCING sreel_ FIPEPROO~!N(.;_ -SAM~LES: ~ NUMBER:~ fr'PE ~ ~ M'-"""'"/OA!~ M~ Numoels'PS: ~~tJ M /('m(,,~ = 1nsoeetton Dote: /t/llt,,[dl REPoRt · -.:J;, oJ ~. ~o '5/4'31 . . rL- SPECIAL INSPECTION REPORT PROJECT: 1s:rs JOB START: ADDRESS: --',-lt...-,t....L~:......t..J.c...t.L<L....L.EL..:=--i~~-'---------- Cl1Y: c;; CB Q/3'/13 JOB STOP: ' PLAN FILE #: ___ _ TYPE OF OBSERVATIONS: MASONRY_ .REINFORCED CONCRETEQ(. FIELD WELDING_ EPOXY_ PRESTRESSED CONCRETE_ SHOP WELDING_ BOLTING_ REINFORCING STEEL_ FIREPROOFING_ SAMPLES: NUMBER: ..j 1YPE: ---'----'=-'--=-<-=--c'--'-'----=~'tJ.:....c~;_;;:~c.-.C>.,..__ ____ ~---1--- Materials/Design Mix Numbers/PSI:· Inspectors Signature l •J JnjOrmation <-_ • .To Build On . Page_1_of-l-~. M~ ~ ~ qorl '\-. () f rdc-PROJECT (Name) \ S ~4~"'~' CLIENT . ~ bQA~J> d DATE Iv I)) 1 Q; , cflOO \ (Address) ~'j I f,,,,_d, k '\, \ __ .·,, ..,__ REPORTNO OS~/OZDZ--1 f1':~ I""'\._~'\~ ®*Jing Permit No. Q__; e O [ '?i \\ ·3 Engineering • Consulting • Testing INSPECTION REPORT Architect Plan File No. ________________ _ Engineer ____ ~--------------Govt. Contract No. ________________ _ OSAorOSHPD#-------------- Contractor ____ -'---------------Other_-'-------------------- INSPECTION MAT'LSAMPLING QTY. MATERIAL DESCRIPTION INSPECTION CHECKLIST --OSt=!P"D _ Concrete <::ylinders --~---=.:..::::--RinL-Rebar -----~·--_ Plan &-Specs -OSA ~~ __ Cement ---. _ Ainf.: W.W.F. _ Clearances '---'special -__ Mortar Samples --_ Aini.: Tendons _ Positions __ Mechanical __ Grout Samples -·-_ Cone.: Mix #/psi _Sizes _ Electrical __ Masonry Prisms --_ Cone.: Mix #/psi _Laps _Roofing __ Masonry Block --___ Cone:: Mix #/psi _ Future Continuity #/psi _Concrete __ Fireproofing --_ Grout: Mix #/psi _ Consolidation _Masonry __ Units (block or brick} --_ Mortar: Type/psi _ Mortar Batching _ Struct Steel __ Asphalt Concrete --_ Units: Block _ Electrode Storage __ Prestress Cone __ Roofing -·--_ Units: Brick _ Torque Applied _ Pile Driving __ Re1nf. Steel ---_Steel __ Fireproofing __ Steel --_H.S.Bolts __ Waterproofing __ H.S. Bolts --_ Metal Decking ·--Non-Destructive __ Tendon (PT Strands} --_._ Electrodes __ Soils Technician __ Other --_ Fireproofing __ Batch Plant __ Other --_Other _ Corrective action required __ __ Bolt Pull-Out __ Other --_ Corrections completed ?Sl·B-900-170(2) INSPECTOR NAME_P_:----..._¾-',•=-=aJ\ ____ c\;--'-_0 __ ~ _ryJ __ /\ 0 ::'""" -~· 'I.. . INSPECTORSIGNATURE ~6-~ _-. - . ' ' . ' ' CERT. NO.--\-s--'-~~-·t5~J_6-~~ 7~--- DATE _ __._\ -""T\ \_8 __ )_a_._, ___ _ l,,_ -~-i· ~. <' l _ -~fl Information .. · · ~ • .ToBuild·on· · . '· ... ,:·;·. .• . ~ , ·: . .. .r -.. , , . .., t • •• ,. ,., .... --·~ .. Page_1_of_ Engineering • Consulting • Testing . ~ ., -;-~:-.. ~ ::·.;:.f·;i.}; :. · 1NsPec.r1oi.fRePo'i~-r:..-·. · :_, ·. ,~1s/F.>1t ~~ CLIENT.~ CA\) S-Tc-~<-l_ DATE (t/ 3-·0 lot { i . Architect_-J_6V_N_\F_· Gil_' _l-6_:-w_l s _____ _ Engineer . _ 0GV'I N6 6Nb. Contractor (otJ!)D M .P fld1;;6fl.,,,,1' S j INSPECTION MAT'L SAMPLING QTY ,_OSl-lP0 __ Ccncre'.e Cylinders ----_OSA _Cement -- _Specialty _ Mortar Samples -- _ Mechanical __ Grout Samples -- _Electrical. _ Masonry Prisms -.- ___ Roofing _. Masonry Block -- _concrete _ Fireproofing --___ Masonry __ Units (block or brick) --- ,f-struct Steel _ Asphalt Concrete -- _ Prestress Cone _Roofing -- _ Pile Driving _ Rein!. Steel -- --Fireproofing +steel -- _ Waterproofing _H.S.Bolts -- _ Non-Destructive _Tendon (PT Strands) 1 ___ Sous Tecnnic1an _Other -- _ Batch Plant _Other -- _ Bolt Pull-Out _Other REMARKS PROJECT (Name) I J?IS Tlice4P6-vTtl.-S (Address) }~ '11 k!,vTli6"2£v,ZO w. C,¥2, 1.hM D c 4 l'.j '2.o o ~ REPORTNO. () )Y-/dd-{lc±: --& Buil~ing Permit No. C. 60 I · :>II 3 Plan File No,-------------''----- Govt. Contract No.-------------- OSA or OSHPD #-------------- Other _________________ _ MATERIAL DESCRIPTION INSPECTION CHECKLIST _ Rini.: Rebar _ Plan & S1,0cs - _ Rini.: W.W.F. _ Clearances _ Rini.: Tendons _ Positions _ Cone.: Mix Ii/psi _ S1z,,s _ Cone.: Mix II/psi _Laps _ Cone.: Mix II/psi _ Fut,.ire Cont111u1ty ":ps, ·_ Grout: Mix #/psi _ Consolidation _ Mortar: Type/psi _ Mortar Batcrnng _ Units: Block _ Electrode Storage _ Units: Brick _ Torque Applied _SteelA'r12 '2t. 5!>. J Mb _H.S.Bolts _ Metal Decking OJ0~5A£{1) ___ Electrodescb!f;. _ Fireproofing _Other _ Correcuve action requ,reu __ _ Corrections completed -~O......,(N'-"-·"""'"&_: _l>-=f,-~~V61)=-=--___,6 ...... t\o=-.,__P ___ . .,.....:l>Jc.,;_&._D""'-fN"'-'l::,C.---+-,A~T---C.,_M"""'"j'--S_T-'---c-_<;...=c-L __._fi9___,_B_l"l_1--=--cA_T__,.,cl cvJ~--- ZTT Sovrrf ,t'-NT1_ ':f\>J ~cos , ~f;f;c;(zucv!) ErruP Mo Autl~orized Signature: CERTIFICATION OF COMPLIANCE: To the best of our knowledge, II ofthe reported work, unless otherwise noted, substantially complies with approved plans, specifications and applicable sections of the building codes. This report covers the locations of the work inspected only and does not constitute engineenng op1n- 1on or project control. {J-J. C· . 57 t,.J'o/ 'SO Cit'( Ji-8 I l, GERT. NO. _______________ _ DATE ___ _:.\l+-/_3.--/-u/_o..;_/ _Ui_;_l.:_:M..=6....:_':_],_--"J_ I I .. l •J Information • ®To Build On Engineering • Consulting • resting REPORT OF CONCRETE COMPRESSION TEST TESTED FOR: JACKIE HDR ARCHTICTURE, INC. 9444 FARNHAM ST., SUITE. 3~0 SAN DIEGO, CA 92123 DATE: November i6, 2001 FIELD DA "FA: LOCATION OF PLACEMENT LINE 1. 6 ( F. 6) DATE PLACED TIME SLUMP, IN. AIR CONTENT, % AIR TEMPERATURE, °F CONCRETE TEMPERATURE, °F DATE.RECEIVED IN LAB FIELD DATA SUBMITTED BY MIX DATA SUBMITTED BY November 16, 2001 November 19, 2001 CHRIS REEL PALOMAR TRANS MIX PROJECT: ISIS PHARMACUETICALS 18 91 RUTHERFORD RD. , CARLSBAD REVISION #1 OUR REPORT NO.: 059-10202-3 SUPPLIER DELIVERY TICKET NOJTRUCK NO. MIX NUMBER AND PROPORTIONS CEMENT WATER FINE AGGREGATE COARSE AGGREGATE ADMIXTURE PALOMAR TRANS MIX 304010 NOIE:.Aeel.lCAllLE.ASJM-SIANDABO.S.UNLES~O.TllERWISEJNOlCAil;D~SLut.e:..C~AIB.COHIEKLI:2:ll:lliEXCLUl2lti(LSE(,._O);JfMP..EB:ATIJB~(9.3);_Cl'LIND.l:BS:_Cll,_9Jl(EXCl.\JDJtiG..SecC.Jl.2.2J;.SAMe.LJNG;.C112:9L COMPRESSION TEST RESULTS I SPECIMEN TEST I LABORATORY IDENTIFICATION AGE DATE OF I NUMBER OijSETNO. (DAYS) TEST i I 4648 A 7 11/23/01 ' 4648 B 28 12/14/01 I 4648 C 28 12/11/01 I , ' . {· - .. -•,'.' '•' . ; SPECIFICATIONS I 28 REMARKS. K Cylinders made by PSI representative. Cylinders made by Architect's or Contractor's representative. ASTM.C39-96; C1231-93 TOTAL ·CYLINDER LOAD DIAMETER (LBS.) a (IN.) 119000 6.00 1Gi-ood 6.00 155000 6.00 ,_ ?, '',:',.,- Cylindeis Jl!cked·up by PSI K representative. Cylindeis delivered .to PSI labora!OI)'. All cylinders capped in accordan¢e with ASTM cc: City of Carlsbad, Good and Robers, Tim Heinichen CYLIN0ER COMPRESSIVE AREA STRENGTH (SQ.IN.) (PSI) TYPE OF BREAK 28.27 4210 Cone 28 .27 5700 Cone & Shear 28.27 5480 Cone & Split ~ 'it, {~,-~.' '•' t '', -'~,, ·:"'"?:': ~~ :• ' ',':.: < 'l!t '1 !. •: ., ',• ,_ . ,-. ,. -4000 ~{~ Test resu(ts comply with applicable ·-~~. X specifications. "'-l_ ~ Test results do not comply wi~o~,"'> applicable specifications. \~ G617-94. O'\~ J"''-l> " ' :I. ' ·V Respectfully submitted, Professional Service Industries, Inc. THESE TEST RESULTS APPi. Y ONLY TO THE SPECIFIC SAMPLES TESTED ANO MAY NOT BE INOIC.I.TIVE Of' THe ENTIRE CONCRETE PlACEMENT. REPORTS MAY NOT BE REPRODUCED, EXCEPT IN FULL, WITHOOT WRITTEN PERMISSION BY PROf'ESSlotW. SERVICE INDUSTRIES, INC. PSI A-200-4 (6)F Professional Service Industries, Inc. • 6867 Nancy Ridge Drive, Suite E • San Diego, CA 92121 • Phone 858/455-0544 • Fax 858/455-1170 l ;J Information ~ • .ToBuildOn Engineering • Consulting • testing Page_1_of -l- lNSPECTION REPORT CLIENT J}) ~ /JJ .. tJ/_t, J Ne_ DATE i '6--,t'{-a I Architect __________________ _ Engineer ...... _l'u __ U_l_~-----------'------------ Contractor _________________ -- INSPECTION MAT'LSAMPLING QTY __ OSHPD __ Concrete··Cylinders ___ OSA __ Cement -- __ Specialty __ Mortar Samples -- _ Mecliariical _ Grout Samples __ Electrical __ Masonry Prisms -- __ Roofing _ Masonry Block --·- __ Concrete __ Fireproofing -- _Masonry __ Units (block or brick) -- ~true! Steel __ Asphalt Concrete -- __ Presti'ess Cone __ Roofing -- __ Pile Driving __ Reinf, Steel __ Fireproofing __ Steel -- _·_.waterproofing __ H.S. Bolts --__ Non-Destructive __ tendon (PT Strands) __ Soils Technician . __ Other -- __ Batch Plant __ Other· -- __ Bolt Pull-Out __ Other -- PROJECT (Name)_L_S.-...C...t---'S.'----____ _ (Address) L B' ~ L ~ fo,t/> ,tJ c..,s~ REPORT NO. 6~:tow2- Building Permit No. C..~ O t ~vt.3 Plan File No. ________________ _ Govt. Contract No. _______________ _ OSAorOSHPD#-------------- Other ___________________ _ MATERIAL DESCRIPTION t:4!PECTION~~ ___ Rini,: Rebar _ n &Specs _ Rini.: W.W.F. _ Clearances _ Rinf.: Tendons _ Positions _ Cone.: Mix #/psi _Sizes _ Cone.: Mix #/psi _Laps _ Cone.: Mix #/psi _ Future Continuity #/psi __ _ Grout: Mix #/psi _ Consolidation _ Mortar: Type/psi Mortar Batching _ Units: Block ~ectrode Storage 00 eAJ _ Units: Brick .:...__~!eel Jl.3"6 _T~e~lief' De Q;_k tfl~ _H.S.Bolts ~ Metal Deckin~A K Electrodes _ Fireproofing _Other ~orrective action required~ _ Corrections completed zc::::: .• CERTIFICATION OF COMPLIANCE: To the best of our knowledge, all of the reported work, unless otherwise noted, substantially complies with approved plans, specifications and applicable sections of the building codes. This report covers the locations of the work inspected .only and does not constitute engineering opin- ion or project control. INSPECTOR SIGNATUR PSI-B-900-170(2) CERT. NO. $/lvv ~0 7~ DATE __ /_~--~...;____,{ _______ _ ' t•._~;,Jnformation ~.-1!1• .To Build On Page_1_of_ Engineering • Consulting • Testing INSPECTION REPORT ·CU ENT rfbrt ~ /;J.l C:...., DATE t 2..-t3-o I Architect ____ -'---------------- Engineer De.,U\IM,., Contractor: __________________ _ INSPECTION MAT'L SAMPLING QTY __ OSHP.D ___ Concrete C.ylinders ~ _____ OSA __ Cement --__ Specialty __ Mortar Samples -- _ Mechanical . __ Grout Samples --___ Electrical __ Masonry Prisms· --__ Roofing __ Masonry Block -- _Concrete __ Fireproofing -- _Masonry __ Units (block or brick) ¥_Struct Steel __ Asphalt Concrete __ Prestress Cone __ Roofing -- __ Pile Driving _. _ Reinf. Steel __ Fireproofing __ Steel --- __ Waterproofing __ H.S. Bolts -- __ Non-Destructive __ Tendon (PT Strands) -- __ Soils Technician __ Other ---- __ Batch Plant __ Other ---- __ Bolt Pull-Out __ Other -- REMARKS PROJECT (Name)__.;;l--_S---=-l,_$ _____ _ (Address) l·fl, J /w.U.,, tt..liM,'b ab cw REPORT NO. C9s-Gl-l02ef"L -7 , Building Permit No. C. 0, o ~ '1 L L 3 Plan File No. ________________ _ Govt. Contract No.------'----------- OSA or OSHPD #-------------- Other_~----------------- MATERIAL _DESCRIPTION INSPECTION C~~ __ Rini.: Rebar ~an&Specs _. _ Rini., W.W.F. _ Clearances ·-Rini.: Tendons _ Positions _ Cone.: Mix #/psi _ Sizes _ Cone.: Mix #/psi _Laps _ Cone.: Mix #/psi _ Future Continuity #/psi __ Grout: Mix #/psi _ Consolidation __ Mortar: Type/psi _ Mortar Batching ._ Units: Block _b6.eectrode Storage V IJ2...t,, _ Units: Brick RTorq~lied ~'.~~ 1 Bo~it'~ w PPQ~ _ Metal Decking ~ Electrodes L""7 l r--a _ Fireproofing l;l_gorrective action required~ _Other _ Corrections completed Jlll"~t!N ~of!6 u,u,~~ d-/_ ftt..-e.22-.. S7S~ As ----- CERTIFICATION OF COMPLIANCE: To th·e best of our knowledge, all ofthe reported work, unless otherwise noted, substantially complies with approved plans, specifications and applicable sections of the building codes. This report covers the locations of the work inspected only and does not constitute engineering opin-· ion or project control. CERT. NO. s ,(J.-1..J--~ ~ ]2-f DATE-,,------------------ l iiJ, lnformatic ~-• .. ToBuildOn Engineering • Consulting • Testing Page_1_of_ INSPECTION REPORT · CLIENT#fbrt ~ /;..,C:...., DATE l 2..-t1"""° f PROJECT (Name)----'J..-_S--=-.l,_.S _____ _ (Address) i'il~J=IG;[J:{;Ff'EAm;;).»-;:;:,f2 b cfktl-b Architect ___________ ~'--------- REPORT NO. (9 ~-toz.rfL -7 , Building Permit No. C~(;S-e:i.::S~ Plan File No. _______________ _ Engineer ku \.1Ll., Govt. Contract No. _______________ _ OSA or OSHPD·#-------------- Contractor. _______ ~-----,.--------Other __________ '---------- INSPECTION MAT'L SAMPLING QTY MATERIAL DESCRIPTION INSPECTION C~~ __ OSHPD --. Concrete Cylinders -·-· _ Rinf.:'Rebar ~an&Specs __ OSA __ Cement --_ Rinf.: W.W.F. _ Clearances __ Specialty __ Mortar Samples --. _ Rini.: Tendons _ Positions __ Mechanical __ Grout Samples --__ Cone.: Mix #/psi _Sizes __ Ele9trical __ Masonry Prisms --_._ Cone.: Mix #/psi _Laps _Roofing __ Masonry Block _ Cone.: Mix #/psi _ Future Continuity #/psi ___ concrete __ Fireproofing --_ Grout Mix #/psi _ Consolidation __ Masonry __ Units (block or brick) --_'Mortar: Type/psi _ Mortar Batching -.¥.,struct Steel ·-. _ Asphalt Concrete --_ Units: Block ~ctrode Storage lvlllf.<_ -.-Prestress Cor:ic __ Roofing --_ Units: Brick X.. Torq~lied __ Pile Driving _. _ Reinf. Steel ~'.;~ 1 sot~~ . w p~~ __ Fireproofing __ Steel __ Waterproofing __ H.S. Bolts --_ Metal Decking __ Non-Destructiv.e __ Tendon (PT Strands) --· ~Electrodes £,""Jl T-PJ __ Soils Technician __ . Other --_ Fireproofing ~orrective ac~ion required&. __ . Batch Plant __ Other --_Other __ Bolt Pull-Out __ Other -·-·-_ Corrections completed REMARKS Jw~a-w ~cJf6 ~~~ d-?-ftt.-e.2Z-t. S:fS~ A.,.s -----" CERTIFICATION OF COMPLIANCE: To the best of our knowledge, all of the reported work, unless otherwise noted, substantially complies with approved plans, specificaticms and applicable sections of the building codes. This report covers the locations of the work inspe_cted only and does not constitute engineering opin- ion or project control. INSPECTOR SIGNATURE PSl·B-900-170(2) CERT.NO. £,{}rtJ-~~ ]2_.@ DATE----------~------- l liJ lriformatio • .ToBuildOn Engineering • Consulting • Testing Page_1_of _f_ INSPECTION REPORT CLIENT JAVL /U.t,J/-t JAR_ DATE i 2,;...,1,'{ -0 I Architect ____ -'-----------------"--'- Engineer_]'u __ V_t_!v-e_ ____________ _ Contractor. _________________ _ INSPECTION MAT'LSAMPLING QTY __ OSHPD __ Concrete Cylinders --__ OSA __ Cement -. Specialty . __ Mortar Samples --· _ Mechaoical ___ Grout Samples -- __ Electrical __ Masonry Prisms _Roofing __ Masonry Block -- _concrete __ Fireproofing -- _Masonry __ Units (block or brick) ---- .-t6-struct Steel __ Asphalt Concrete -- __ Prestress Cone . __ Roofing -- __ Pile Driving __ Reinf. Steel __ Fireproofing __ Steel -- __ Waterproofing __ H:S. Bolts -- . __ Non-Destructive __ Tendon (PT Strands) ___ Soils Technician ___ Other -- __ Batch Plant _. _Other -- __ Bolt Pull-Out · __ Other -- PROJECT (Name)_L_S.---"-{.-"'$'----____ _ (Address) l,6>·~L_,,,~__,:_,W c..,s~ REPORT NO.· 65<i :t'02..o2--8' Building Permit No. ~:a:i-:_~--z;-t-;:B Plan File No, ________________ _ Govt. Contract No.--~------------ OSA or OSHPD #-------------- Other--~----------------- MATERIAL DESCRIPTION J:PECTION~~ _ Rinf.: Rebar _ n&Specs -. Rinf.: W.W.F. _ Clearances _ Rinf.: Tendons _ Positions ___ Cone.: Mix #/psi _Sizes _. __ Cone.: Mix #/psi _Laps _ Cone.: Mix #/psi _ Future Continuity #/psi _ Grout: Mix #/psi _ Consolidation _,Mortar: Type/psi Mortar Batching _ Units: Block ~ectrode Storage Ou e,AJ ·-Units: Brick _Twrnlie/J -~teel A.3f, D<-Q,,_,~ &flf _H.S.Bolts .X.. Metal Deckin~A _ti_ Electrodes _ fireproofing _Other ~orrective action required~ _ Corrections completed ==-- CERTIFICATION OF COMPLIANCE: To the best of our knowledge, all.of the reported work, unless otherwise noted, substantially complies with approved plans, specifications and applicable sections of the building code$. This report covers the locations of the work inspected only and does not constitute engineering opin- ion or project control. IN$PECTOR SIGNATUR PSl-13-900-170(2) CERT.NO. s~~O. 7~ DATE __ /_~ __ '-/,,,e-,_(.__ _____ _ l .-..:~•JlnJormatic .. ~.., ••. To Build On Page_1_of_ Engineering • Consulting • Testfng INSPECTION REPORT CLIENT '4-)>t'( ~Jd-)l>JC, DA TE L 1..:-l, 4-pf Architect_~----------------- Engineer DE\11~ Contractor.-------------"------,---- INSPECTION MAT'LSAMPLING QTY __ OSHPD __ Concrete Cylinders -- _OSA _-_Cement --- _. _ Specialty ___ Mortar Samples ·-- __ Mechanical __ Grout Samples -- __ Electrical __ Masonry Prisms -- _Roofing ____ Masonry Block -- _Concrete __ Fireproofing --__ Masonry __ Units (block or brick) ---- ___ Struct Steel __ Asphalt Concrete -- __ Prestress Cone __ Roofing -- __ Pile Driving __ Reinf. Steel -- __ Fireproofing _-_Steel -- __ Waterproofing __ H.S. Bolts -- __ ·Non-Destructive ___ Tendon (PT Strands) -- __ Soils Technician __ Other --- __ Batch Plant __ Other __ Bolt Pull-Out __ Other REMARKS PROJECT (Name)_._f _S_l_S _____ _ (Address) t7?fT-rn-~ REPORT NO. &4:i-LD.2.o 2... -9 ' Building Permit No. __ .,_/ ~3"'-'--1_,)__,,.3'-------- Plan File No. ________________ _ Govt. Contract No. _______________ _ OSA or OSHPD #-------'--------- Other ___________________ _ MATERIAL DESCRIPTION INSPECTION 4'~ _ Rini.: Rebar _Jlplan & Specs _ Rini.: W.W.F. _ Clearances _ Rini.: Tendons _ Positions _ Cone.: Mix #/psi _Sizes _ Cone.: Mix #/psi _Laps .-Cone.: Mix #/psi . _ Future Continuity #/psi _ Grout: Mix #/psi _ Consolidation _ Mortar: Type/psi _ Mortar Batching _ Units: Block _ Electrode Storage -_ Units: Brick _ Torque App~ _Steel tx__~, ~ I --H.S. Bolts .-Metal Decking ___ Electrodes _ Fireproofing __h(_ Corrective action required~ ~Other _£?A-# ~ &1-"'IJ,S(Dv . tr M 6"2.."2'1 ... , J:d oz/ti:'-Corrections completed -V 1~ Wvey ~/J.Je.lts e,/-HA-e__2..w tJN &t-LS J E/J aN CERTIFICATION OF COMPLIANCE: To the best of our knowledge, all of the reported work, unless otherwise noted, substantially complies with approved plans, specifications and applicable sections of the-building codes. This report covers the locations of the work inspected only and does not constitute engineering opin- ion or project control. INSPECTOR NAME fl Mi,~ /w-eP(_ NSPECTORSIGN;;U~:------ ,s1-s-soo-110<2J CERT. No.__,,S=~~---=~;:;.....;;.~-1r-J;):.:..__,,,J"'""2$~--- OATE _ _::;_l ~2-~"-7-=----e----'-/ _____ _ l iiJ Information . . • .ToBuildOn Engineering • Consulting • Testing REPORT OF MOISTURE DENSITY RELATIONSHIP OF SOIL TESTED ·FOR: JACKIE PROJECT: ISIS PHARMACUETICALS CIJJ:9J.-RU!f,.H-E-RJ:<:0R,D_R1). , CARLSBAD HDR ARCHTICTURE, ING. 9444 FARNHAM ST., SUITE 300 SAN DIEGO, CA 92123 OUR REPORT NO.: 059-10202-10 DAT_E: ____ January 10, 2002 ------r·---------•• ----••• •-~-•• ~,. ----• --.· •-.. ==~===·--·::: . ..:::.:..;:-::-::·.:: -!:::::::: ::::::::: :::::;::: : ::·: :-: ::: : : t :: !: :! ::::::::: !!:t:::::-:::t::::: 144~=-:_::_:~::_i_:~i_!!_:_:_::_:~:~:_!!_:_!:_·:_:~:~·-··_·_·_··-·~·~·-··-·-··-·-·~·'-----~ :::::!P! M!t:::1: ••••..... ::::::·f! :t:i::::: ........ . :1·::1·:fr1· ::::::::: ........ . :.::.:.::. :ttt!!t!: ••••••••• z:::::·:r ··:1····· ...... 111 :t. ::::: lliHH 1-. !H:HH: I-.. t ... ' tt.t::t::: 0 140 .::.t:1,1 ....... .. 0 !iifHfH :H!:H:: LL :!!!t!.!t! {itp,gg u iiHi!ill tlh!-:r:: ······-··· I\rn ::::::::: ......... . ...... ,. . ....... . ......... ........ . .................. . .................. . . ................ . ......... ·····-··· ................... ......... ···-----··· .......... ··-·· .... .......... ········· ................... .............. .......... . .................. ......... ........ . TEST DATA Visual Classification Red Brown Silty Sandy Sand PSI Lab# 02-005 :i:mport Sample Source Method of Test ASTM D 1557-91 Rammer: Mechanical Procedure A Method of Preparation: Moist Test Results M9ximum Ory Density Optimum Moisture Content 129. o lbs/ft'. 8.5 % en :::) iHir::H :~n.i:n: ......... ::::::::: :::::-:::: Atterberg Limits (ASTM 0431a.9aJ t:1;r:.Jlt! iHH!ft: ·········· ..... -..... LL· PL· Pl.· Spec·t·c Grav,·ty· 2 50 (estimate) u ~ w a. , .. ,111 • twr;:!,: .·.·.· .. ·.·.·.·.·.· .·:·.·.·.·.· .. ··.·.· .·.·.·.·.•.·.·• .. · · · · . 11 • • 135~:_!_1:_:_1r~t_l~:~:1~·~:_r:_:~:1-...,.-+---,-11---+-----1-------.-"-----~----.----.----....... --~ ~!i~IIm ill!l!~~~ '.~;'.~~~~ '.~;;;~'.~~ '.~~'.~~'.~~ ~;~'.~~~;~ ~~~~;'.~~ ~~~~~~ :~~ ~~~~ ~~~ ~~~~ &1 J.ii~ (/) en ..J -~ en z w C >-~ C 128 120 2 4 6 8 10 12 14 MOISTURE CONTENT, PERCENT OF DRY W!=IGHT ~EMARKS: cc: City of Carlsbad, Good and Robers, Tim Heinichen "PORTS W.Y NOT BE REPROOUC£D. EXCEPT IN Fl.11.L. WITHOUT ~ITTEN PERMISSION BY·PROFESS~ ScRVICE INDUSTRIES. INC. 16 Grain Size Analysis (ASTM C136-96a and/or C117-95) Sieve Percent Size Passing Respectfully submitted, Professional Service Industries, Inc. A4r2c,4e(__ Dale Bodman, RCE Vice President ,00-1 (3)F Professional Service Industries, Inc. • 6867 Nancy Ridge Drive, Suite E • San Diego, CA 92121 • Phone 858/455-0544 • Fax 858/455· 1170 l ;Jinformatic ~ • .ToBuildOn E,igineering • Consulting • Testing CLIENT Qorl '1--Q l4 DATE~tv-,-W_, _<.t;_,-'--cflOOi---=·--=----\ Page_1_of l. INSPECTION REPORT ~. M~ ~ '-.Q. PROJEC(:~::::~~ Cacl\~d Architect t\ 6' L-.._ . '\. \ .. ,, n "':--_ REPORT NO _ OS9-/OZDZ.-! \:::\ ~ \~ q':::~ [""' ~ ,-{,UJ~ ~ ®*Jing Permit No. -efs--(5,.,[--~-\t:3 Plan File No, ________________ _ Engineer __ ~-~~-----------'---Govt. Contract No. ______________ _ OSAorOSHPD#-------------- Contractor. __________________ _ Other ___________________ _ INSPECTION ~ MAT'LSAMPLING QTY MATERIAL DESCRIPTION INSPECTION CHECKLIST __ OSHPD __ Concrete Cylinders --_ Rinf.: Rebar _ Plan & Specs _OSA~ __ Cement --_ Rinf.: W.W.F. _ Clearances -'--special · ~ _. _ Mortar Samples -·-_ Rinf.: Tendons _ Positions _ Mechanical · __ Grout Samples --__ Cone.: Mix #/psi _ Sizes __ Electrical __ Masonry Prisms --_· _ Cone.: Mix #/psi _Laps _.Roofing __ Masonry Block --_ Cone.: Mix #/psi _ Future Continuity #/psi __ concrete __ Fireproofing --__ _ Grout: Mix #/psi _ Consolidation ___ Masonry __ Units (block or brick) --_ Mortar:. Type/psi _ Mortar Batching __ $true! Steel __ Asphalt Concrete --_ :units: Block _ Electrode Storage __ Prestress Cone _._Roofing ----_ Units: Brick _ Torque Applied __ Pile Driving __ Reinf. Steel --_Steel ___ Fireproofing __ Steel --_H.S.Bolts __ Waterproofing ' ___ H.S. Bolts --_._ Metal Decking __ Non,Destructive __ Tendon (PT Strands) --___ Electrodes ___ Soils Technician __ Oiher --_ Fireproofing __ Batch Plant __ Other --_ Other _ Corrective action required __ __ Bolt Pull-Out __ Other --_ Corrections completed PSI-B-900-170(2) INSPECTOR NAME i::~QJ-c:b 0 ~ '70 ,(\ n ~"'= .. ~· . ro, ~ ~ INSPECTORSIGNATURE ~6,-~ ~'--' cgRT. No.--P£_,_~-----=--0_J_.__6-_·1--'----7 ___ _ DATE_\L----¼l l--=-8--,.._;.)ci___._, __ _ SPECIAL INSPECTION REPORT JOB START: JOB STOP: PLAN FILE #: ___ _ TYPE OF OBSERVATIONS: MASONRY_ R~INFORCED CONCRETEQ(__ FIELD WELDING_ EPOXY_ PRESTRESSED CONCRETE_ SHOP WELDING_ BOLTING_ REINFORCING STEEL_ FIREPROOFING_ SAMPLES: NUMBER: ..J TYPE: -'--'=-'-=-'-=-------....;....L._;;:;~~,___~---~----J--- Materials/Design Mix Numbers/PSI: I r · J ~-/ O;){),J__-2 FROM : PEG GRIFFITH i;:"AX NO. : 8592'?48379 Nov. 19 2001 03:381-'M P2 I ~ S. I. SPECIAL INSPECTION RtPORT JOB STAAT: -·--- JOB STOP: PLAN FILE 1,: ___ _ wo. 5/4' 31 . <[~ -- l •J Information ~ • .To Build On Engineering • Consulting • Testing REPORT OF CONCRETE COMPRESSION TEST TESTED FOR: JACKIE HDR ARCHTICTURE, INC. 9444 FAANHAM ST., SUITE 300 SAN DIEGO, CA 92123 DATE: November 16, 2001 FIELD DATA: LOCATION OF PLACEMENT LINE 1. 6 (·F. 6) DATE PLACED TIME SLUMP.IN. AIR CONTENT, % AIR TEMPERATURE, °F CONCRETE TEMPERATURE, °F DATE RECEIVED IN LAB FIELD DATA SUBMITTED BY MIX DATA SUBMITTED BY November 16, 2001 November 19, 2001 CHRIS REEL PALOMAR TRANS MIX PROJECT: ISIS PHARMACUETICALS """""1"8~1:JTH'E-R'FeR'J:)'""'R'E) . I CARLSBAD OUR REPORT NO.: 059-10202-3 SUPPLIER DELIVERY TICKET NO.frRUCK NO. MIX NUMBER AND PROPORTIONS CEMENT WATER. FINE AGGREGATE COARSE AGGREGATE ADMIXTURE PALOMAR TRANS MIX 304010 COMPRESSION TEST RESULTS ASTM 039-96; C1231·93 i SPECIMEN ; TEST . ·--..... ------·-·--, LABORATORY I IDENTIFICATION' AGE 1 NUMBER I OR:SET NO. i (PAYS) : TOTAL CYLINDER i CYLINDER COMPRESSIVE I ~~~~t -··-· _: -.. ~iri _. ·-·, -·-Dl~~E/~_R ___ I (:0~!~--1-s-T_R(_i~_f_JT_H_ -·····--~~~-~~ ~~~~~---·. __ j 4648 4648 4648 I I A B C --------.-·--·-.. -·--. SPECIFICA TiONS 7 ! 11/23/01 28 i 12/14/01 28 : 12/14/03: : 28 119000 6.00 28.27 4210 Cone I -~-----<--·----·--. --·---··! l :! I 4000 ---------~------·-------------·--------· -----·-·-----------'-------'------·----. -•• _J REMARKS: _K Cylinders made by PSI representative. Cylinders made by Archilecrs or ConlractOl's representative. Cylinders picked up by PSI 1f.. representative. Cylinders delivered lo PSI labo,:alory. Test results comply with applicable specifications. Test results do not comply with applicable specifications. All cylinders capped in accordance with ASTM C617-94. cc: City of Carlsbad, Good and Robers, Tim Heinichen THESE TEST RESU\. TS APPi. Y ONLY TO THE SPECIFIC SAk'P\.ES TESTED ANO l,IAY NOT BE INOICA TM OF THE Em!RE CONCRETE PL>.CEMENT. REPORTS l,IAY NOT BE REPROO\JCl;O. EXCEPT IN FUI.L. WITliOVT WRITTEN PERMISSION BY PROFESSIONAL SERVICE INO\JSTRIES, INC. Respectfully submitted, Professional Service Industries, Inc. dtv~ Dale Bodman, RCE Vice President PSI A-200,4 (C)F Professional Service Industries, Inc.• 6867 Nancy Ridge Drive, Suite E • San Diego, CA 92121 • Phone 858/455-0544 • Fax 858/455-1170 Engineer t,; Govt. Contract No. I • S'l~cf OSA o;s.SHP~ J / Contractor. c-uv Other '£,J~ fll/Jr.l!J-"6~ / i J,;_ 0 'J -I -v1,,..,..,. I INSPECTION ~ I I MAT'LSAMPLING QTY MATERIAL DESCRIPTION j1NSPECTION itx,LIST _OSHPD~ I _ Concrete Cylinders --_ Rinf.: Rebar _ Plan & Specli$i l ~ ~ I _OSA I _-_Cement _ Rinf.: W.W.F. --_ Clearances _Specialty ~~, I _ Mortar Samples --_ Rinf.: Tendons _ Positions _ Mechanical _ Grout Samples __ Cone.: Mix #/psi _ Sizes cJ;;: _ Electrical _ Masonry Prisms _ Cone.: Mix #/psi --_ Laps • _Roofing ~ l I _ Masonry Block --_ Cone.: Mix #/psi _ Future Continuity #/psi _cooo,et,1 . _ Fireproofing _ Grout: Mix #/psi _ Consolidation -- _M~ :/ _ Units (block or brick) --_ Mortar: Type/psi _ Mortar Batching ~~;str::: Cone C , _ Asphalt Concrete ---. _ Units: Block _ Electrode Storage ~ --_ Units: Brick _ Torque Applied _ Pne Driving ¼ /( --_Steel · teel _Fireproofing ~ A _Steel --_. _ H.S. Bolts _Waterproofing _H.S.Bolts --_ Metal Deckinn --\ _ Non-Destructive ?js.s.o _Tendon (PT Strands) --· _. _ Electrodes F. r,-0 ( C if / _Soils Technician _Other --_ Fireproofing _ Batch Plant _Other --_Other, _ Corrective action requirectAb _. _ Bolt Pull-Out _Other --_ Corrections completed REMARKS . -:ZtJOS,£ addf'-1 /~~ foq vUucb h~ er ba, '(dtc.,, ,; .f k/ ~~ jj~e /ctt,jef, I~ ~/4 ~~ czf /;--3 i5/.3ap/ lr.if3/ S6.0 (-eer h· (·~c( cal}ah!Et,,.:)~½,~ AlJ,,/Jh s/~/ 5J2ec/al /~t}@(!)br US e d_ t L, /r"e,!/4 f o 11 f!nttar:f5/Jdl/r e I' Sec6~ 2. 2./.5 /4 ;' . t' f>~ dY't,. ~ ~/4 a f 2 S s .. cft:Jcas...sec; w. S,'5' ,KJeu,-; e. CERTIFICATION OF COMPLIANCE: To the best of our knowledge, II of the reported work, unless otherwise noted, substantially complies with approved plans, specifications and applicable sections of the building codes. This re~ort covers tlie-locatioris o!fhe '::'~k inspected only and does not constitute engineering opin- ion orprojeci control../42, /2 ~ fr fjttLt fi,_,ta( ~, ~@e/' 0/' C1;a1e.e 2([3,Q INSPECTOR NAME Cat··luJ~J? b_ L CERT. N0~--'(9;...;:~;...:;a.c..::tfo:;,_~-....._~--=-d:--____ _ ~~~1~ ) INSPECTORSIGNATURE Ct::i-r(w~,~y DATE 2 I RN$/ {Cue PSl-8-900-170(2) .• ,. .f . l •J Inforrnatio··-1!!. • ,.To Build On Page_1_of_ Engineering • Consulting • Testing INSPECTION REPORT /.S/.> ~#/J/Zm/JtEtfT/~/JL.f CLIENT8fll~87£J DATE /2 ~3 ,,.0/ Architect~'M~1/J~~~----------"-----'- Engineer----'-'.~=---zi--'· l(;'-'----')rJ'---E~---,---------,------'-----'- Contractor.~ t;/2oe-m,, 11.J' /CMJ I INSPECTION MAT'L SAMPLING _QSHPD _ Concrete Cylind.ers _QSA _Cement _Specialty _ Mortar Samples _ Mechanical __ Grout Samples _ Electrical ._ Masonry Prisms _Roofing . __ Masonry Block _Concrete __ Fireproofing _Masonry _ Units (block or brick) ~ Struct Steel __ Asphalt Concrete _'Prestress Cone . _Roofing __ _ Pile Driving ._ Rein!. Steel _ Fireproofing _Steel _Waterproofing $H.S. Bolts _ Non-Destructive _Tendon (PT Strands) __ Soils Technician _Other _ Batch Plant _Other _Bolt Pull-Out _Other REMARKS 11/o ;)J$/E~?M?~ QTY -- -- -- -- -- -- -- -·- -- -- .s_ -------- IB/5 LAI] ·~ PROJECT (Name) /J1 £22,4.;J;We (Address) /3f/ ./?uzy&»%,#iO &JJ -&@1~,M. REPORTNO. ()y--~a_-f' Building Permit No. CtJ &/3113 Plan File No. ________________ _ Govt. Contract No. ______________ _ OSAorOSHPD#-------------- Other_--'------------------ MATERIAL DESCRIPTION INSPECTION CHECKLIST _ Rini.: Rebar ___ Plan & Specs _ Rini.: W.W.F. _ Clearances _ Rini.: Tendons ___ Positions _ Cone.: Mix #/psi _Sizes- ___ Cone.: Mix #/psi _Laps -: _ Cone.: Mix #/psi _ Future Continuity #/psi _ Grout: Mix #/psi _ Consolidation _ Mortar: Type/psi _ Mortar Batching _ Units: Block _ Electrode Storage XUnits&~ _ Torque Applied . Steel ~ 1~..J I • ·--_ H.S. Bolts _ Metal Decking _ Electrodes _ Fireproofing _Other _ Corrective action required __ _ Corrections completed CERTIFICATION OF COMPLIANCE: To the best of our knowledge, all of the reported work, unless otherwise noted, substantially complies with approved plans, specifications and applicable sections of the building codes. This report covers the locations of the work inspected only and does not constitute engineering opin- ion or project control. INSPECTORNAME ~.,. Aft,,,e,i::I ~:Jt"''"j INSPECTORSIGNATURE v~;/I PSI-B-900-170(2) CERT. NO. 6 @·f: DATE__,_/.=..,.2__;...;/3""""'---~-=-{J-r-,I _____ _ EsGil C.orporation 1n Partnersliip witli (jovernment for '13uifaing Safety DATE: December 18, 2001 JURISDICTION: Carlsbad PLAN CHECK NO.: ()1-3313 SET:IV PROJECT ADDRESS: -1891 Rutherford Rd PROJECT NAME: Isis Pharmaceuticals D D D D D ·~ D The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's building codes. The plans transmitted herewith will substanti~lly comply with the jurisdiction's building codes when minor deficiencies identified below are resolved and checked by building department staff. The plans transmitted herewith have significant deficiencies identified on the enclosed check list and should b.e corrected and resubmitted for a complete recheck. The check list transmitted herewith is for your informati.o.n. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. The applicant'$ copy of the check list is enclosed for the j(Jrisdiction to forward to the applicant . contact person. The applicant's copy of the check list !las been sent to: Esgil Corporation staff did not advise the applicant that {he plan check has been completed. Esgil Corporation staff did advise the applicant that the'·plan check has been completed. Person contacted: Telephone#: Date contacted: (by: ) Fax #: Mail Telephone Fax. In Person IZJ REMARKS: The Building Official shall review the special inspection program submitted by the applicant. By: Abe Doliente Esgil Corporation D GA D MB D EJ D PC Enclosures: 12/18/01 trnsmtl.dot 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (858) 560-1468 + Fax (858) 560-1576 EsGil Corporation '1.n Partnersli.ip witli. (Jovemment for '.Builaing Safetg DATE: December 13, 2001 JURISDICTION: Carlsbad PLAN CHECK NO.: 01-3313 PROJECT ADDRESS: 1891 Rutherford Rd PROJECT NAME: Isis Pharmaceuticals SET: III ~NT ~ D PLAN REVIEWER D FILE D The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's building codes, D The plans transmitted herewith will $Ubstantially comply with the jurisdiction's building codes when minor deficiencies identified below are resolved and checked by building department staff. D The plans transmitted herewith have significant deficiencies identified on the enclosed check list and should be corrected and resubmitted for a complete recheck. ~ The check list transmitted herewith is for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. D 1he applicant's copy of the .check list is enclosed for the jurisdiction to forward to the applicant contact person. l:8:J The applicant's copy of the check list has been sent to: 'H DR Architecture 9444 Farnham St., Suit 300, San Diego, CA 92123 D Esgil Corporation staff did not advise the applicant that the plan check has been completed. -~ Esgil Corporation staff did advise the applicant that the plan check has been completed. Person contacted: Leaf Blevin.s Telephone#: 858/712-8400 Date contacted: \d{\~ (byJ=s) Fax #: -8333 Mail-Telephone D REMARKS: Fax-In Person By: Abe Doliente Esgil Corporation [8J GA D MB D EJ D PC Enclosures: 12,/5/01 trnsmtl.dot 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (858) 560-1468 + Fax (858) 560-1576 Carlsbad 01-3313 III December 13, 2001 RECHECK PLAN CORRECTION LIST JURISDICTION: Carlsbad PROJECT ADDRESS: 1891 Rutherford Rd DATE PLAN RECEIVED BY ESGIL CORPORATION: 12/5/01 REVIEWED BY: Abe Doliente FOREWORD (PLEASE READ): PLAN CHECK NO.: 01-3313 SET: III DATE RECHECK COMPLETED: December 13, 2001 This plan review is limited to the technical requirements contained in the Uniform Building Code, Uniform Plumbing Code, Uniform MecManical Code, National Electrical Code and state laws regulating energy conservation, noise attenuation and disabled access. This plan review is based on regulations enforced by the Building Department. You may have other corrections based on laws and ordinances enforced by the Planning Department, Engineering Department or other departments. The following items listed need clarification, modification or change. All items must be satisfied before the plans will be in conformance with the cited codes and regulations. Per Sec. 106.4.3, 1997 Uniform Building Code, the approval of the plans does not permit the violation of any state, county or city law. A. Please make all corrections on the original tracings and submit two new sets of prints to: Esgil Corp. or to the bldg. dept. of the juris. B. To facilitate rechecking, please identify, next to each item, the sheet of the plans upon which each correction on this sheet has been made and return this sheet with the revised plans. C. The following items have not been resolved from the previous plan reviews. The original correction number has been given for your reference. In case you did not keep a copy of the prior correction list, we have enclosed those pages containing the outstanding corrections. Please contact me if you have any questions regarding these items. D. Please indicate here if any changes have been made to the plans that are not a result of corrections from this list. If there are other changes, please briefly describe them and where they are located on the plans. Have changes been made not resulting from this list? OYes DNo Carlsbad 01-3313 III December 13, 2001 + PLUMBING, MECHANICAL AND ENERGY CORRECTIONS + PLAN REVIEWER: Glen Adamek 1. Each sheet of the plans must be signed before the permits are issued. Sheets A-102, LF-201 and LF-401 are not signed by the architect sealing the sheets. Business and Professions Code. MECHANICAL (1997 UNIFORM MECHANICAL CODE) 3. Correct sheet M3.2: CorreGt the duct openings in the required fire rated ceilings of rooms L 114 and L 117. Also, provide sections of room showing routes of the exhaust ducts from the flammable cabinets back to the exhaust fan. A) · Sheet M3.2 still does not show the required fire dampers for the exhaust duct openings in the fire rated ceiling membranes for ducts serving the fume hood and tJ')e four 'flammable cabinets' in room # L114 and L117 .. UBC, Section 713.11 #4. Please correct. B) Sheet M3.2 still shows many of the ceiling grills (Duct openings) in the same locations as the 2x4 light fixtures shown on sheets E2.1 and A-104. Please correct. ENERGY CONSERVATION 12. Provide new energy designs matching the plans. The existing energy. design shows R-11 wall insulation in the 2x4 wood stud walls, but the plans show all metal stud walls (the overall R-value for the wood framed wall is larger than the over all R-value for the metal stud walls with the same insulation R-values). Also, the existing energy design shows R-19 roof insulation over the 8 inch thick solid concrete roof system but the plans show R-19 insulation under the roof system and does not show the roof is 8 inch minimum thickness concrete. On the plans clearly show the wall and roof insulation locations, thickness, and R-values, as per the energy design. A) The Documentation Author and the Principal Envelope Designer must sign the corrected E!NV-1 form on sheet M0.1. B) Complete energy plan check will be done when complete corrected envelope energy designs are provided matching. the plans. Note: If you have any questions reg~rding this plumbing, mechanical and energy plan review list please contact Glen Adamek at (858) 560-1468. To speed the review process, note on this list (or a copy) where the corrected items have been addressed on the plans. EsGil Corporation 1.n Partnersliip Witli (jovemment for 'Buifaing Safety DATE: November 28, 2001 JURISDICtlON: Carlsbad PLAN CHECK NO.: 01-3313 PROJECT ADDRESS: 1891 Rutherford Rd PROJECT NAME: Isis :Pharmaceuticals SE:T: II D Al? LICANT K\ REVIEWER D FILE D The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's building codes. · D The plans transmitted herewith will substantially comply with the jurisdiction's building codes when minor deficiencies identified below are resolved and checked by bullding department staff. D The plans transmitted herewith have significant deficiencies identified on the enclosed check list and should be corrected and resuqmitted for a complete recheck. ~ The check list transmitted herewith is for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. D The applicant's copy of the check list is ~nclosed for the jurisdiction to forward to the applicant contact person. · 1:8:1 The applicant's copy of the check list has been sent to: HOR Architecture 9444 Farnham St., Suite 300, San Diego, CA 92123 0 Esgil Corporation staff did not advise the· applicant that the plan check has been completed. ~ Esgil Corporation staff did advise th_e applicant that the plan check has been completed. Person contacted: Leaf Blevins Telephone#: 858/712-8400 D~te contacted: i I I 1 ~-/a, (by: f--A _)() Fax #: -8333 Mail t,/" Telephone Fax..,.--In Person 1:8:i REMARKS: PLEASE FAX CHECKLIST TO MIKE PETERSON AT 760/602-8558. By: Abe Doliente Esgil Corporation D GA D MB D EJ D PC Enclost:1res: 11/15/01 trnsmtl.dot 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (858) 560-1468 + Fax (858) 560-1576 Carlsbad 01-3313 II .November 28, 2001 RECHECK PLAN CORRECTION LIST · JURISDICTION: Carlsbad PROJECT ADDRESS: 1891 Rutherford Rd DATE PLAN RECEIVED BY ESGIL CORPORATION: 11/15/01 REVIEWED BY: Abe Doliente FOREWORO (PLEASE READ): PLAN CHECK NO.: 01-3313 SET: II DATE RECHECK COMPLETED: November 28, 2001 This plan review is limited to t_he technical requirements contained in the Uniform Building Code, Uniform Plumbing Code, Uniform Mechanical Code, National Electrical Code and state laws regulating energy conservation, noise attenuation and disabled access. This plan review is based on regulations enforced by the s·uilding Department. You may have other corrections based on laws and ordinances enforced by the Plar:ming Department, Engineering Department or other departments. The following items listed need clarification, modification or change. All items must be satisfied before the plans will be in conformance with the cited codes and regulations. Per Sec. 106.4.3, 1997 Uniform Building Code, the approval of the plans does not permit the violation of any state, county or.city law. A. Please make all corrections on the original tracings and submit two new sets of prints to: Esgil Corp. or to the bldg. dept. of the juris. B. To facilitate rechecking, please identify, next to each item, the sheet of the plans upon which each correction on this sheet has been made-and return this sheet with the revised plans. C. The following items have not been resolved from the previous plan reviews. The original correction number has been given for your reference. In case you did not keep a copy of the-prior correction list, we have . enclosed those pages containing the outstanding corrections. Please contact me if you have any questions regarding these items. D. Please indicate here if any changes have been made to the plans that are not a result of corrections from this list. 'If there are other changes, please briefly describe them and where they are located on the plans. Have changes been made not resulting from this list? DYes DNo Carlsbad 01-3313 II November 28, 2001 1. Plans and calculations shall be signed by the California state licensed engineer or architect where there are structural changes to existing buildings or structural additions. Please include the California license number, seal, date of license expiration and date plans are signed. Business and Professions Code. + -PLUMB·ING,.MECHANICAL AND ENERGY CORRECTIONS + PLAN REVIEWER: Glen Adamek 3. The required fire dampers at duct openings in fire rated ceilings are not shown on sheet M3.2. Also, Sheet M3.2 shows many of the ceiling grills (Duct openings) in the sa_me locations as the 2x4 light fixtures on sheets E,Z.1 and A-104. Please correct. Show the required ceiling rated fire dampers at duct openings in,the fire rated ceiling membranes. UBC, Section 713.11 #4. Correct the duct openings in the required fire rated ceilings of rooms L 114 and L 117. Also, provide sections of room showing routes of the exhaust ducts from the flammable cabinets back to the exhaust fan. · 5. Please explain the "Closed Use Systems" required fore the proposed use of .Butylithium, CAS# 109-72-8; Diisobutylaluminum Hydride, CAS# 1191-15- 7; Triethylphosphine, CAS# 554-70-1; Ttimethyl Aluminum, CAS# 75-24-1 and Lithium Diisopropylaminda, CAS# 4111-54-0. How and where are the materials transferred and use to maintain the reguirements of "Closed Use Systems." In the Technical Report, oated 25 September 2001 by Eriksen- Rattan Associates Inc. please address where and how the pyrophorics are used to comply with USC, Table 3-D. PLUMBING .(1997 UNIFORM PLUMBING CODE) 8. Plans only shows gas valves just after each gas pressure regulator. Please correct-Gas Riser Diagram on sheet P0.1, plumbing floor plans on sheets P1.1 & P2.2, and details 1 &·2 on sheet P4.1. Show gas valves immediately preceding each gas pressure regulator, as required per UPC, Section 1218.5. ENERGY CONSERVATION 12. Clearly show the required R-11 wall insulation in the 2x4 wood stud walls as per the energy design and R-19 roof insulation over the 8 inch thick solid·concr~te roof system as per the energy design, or provide new energy designs matching the plans. On the plans clearly show the wall and· roof insulation locations, thickness, and R-val.ues, as per the energy design. 14. Thomas B. Todd must sign the ENV-1 form on sheet M0.1 as the Principal Envelope Designer. Note: If you have any questions regarding this plumbing, mechanical and energy plan review list please contact GJen Adamek at (858) 560-1468. To speed the review process, note on this list (or a copy) where the corrected items have been addressed on the plans. DATE'. November 1, 2001 . JURISDICTION: Carlsbad PLAN CHECK NO.: 01-3313 EsGil Corporation 1.n. Partnersliip witli qovemmen.t for '.Bui/ain.g Safety SET:I PROJECT ADDRESS: 1891 Rutherford Rd PROJECT NAME: Isis Pharmaceuticals ~ NT JURIS. -::- 0 REVIEWER D FILE D The plans transmitted herewith have been corrected where necessary and substantially comply whh the jurisdiction's building codes. D The plans transmitted herewith will substantially comply with the jurisdiction's building codes when minor deficiencies identified below are resolved and checked by building department staff. D The plans transmitted herewith have significant deficiencies identified on the enclosed check list and should be corrected and resubmitted for a complete recheck. 1:8:] The check list transmitted herewith is for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. D The applicant's copy of the check list is enclosed for the jurisdiction to forward to the applicant contact person. · · 1:8:] The applicant's copy of the check list has been sent to: HOR Architecture 9444 Farnham St., Suite 300, San Diego, CA 92123 D Esgil Corporation staff did not advise the applicant that the plan check has been completed. 1:8:] Esgil Corporation staff did advise the applicant that the plan check has been completed. Person contacted: Leaf Blevins ( v-H) Telephone#: 858/712-8400 Date contacted: Ii (2.Jo, (by: ~ ) Fax #: -8333 Mail ----Telephone./ Fax/ In Person D REMARKS: By: Abe Doliente Esgil Corporation [81 GA t8:I MB D EJ D PC Enclosures: 10/22/01 trnsmtl.dot 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (858) 560-1468 + Fax (858) 560-1576 r Carlsbad 01-3313 November 1, 2001 PLAN REVIEW CORRECTION LIST TENANT IMPROVEMENTS PLAN CHECK NO.: 01-3313 OCCUPANCY: TYPE OF CONSTRUCTION: III..:N ALLOWABLE FLOOR AREA: 72,000 SF SPRINKLERS?: Yes REMARKS: DATE PLANS RECEIVED BY JURISDICTION: DATE INITIAL PLAN REVIEW COMPLETED: November 1, 2001 FOREWORD (PLEASE READ): JURISDICTION: Carlsbad USE: Office,. lab, warehouse ACTUAL AREA: 19,000 (T.I. only) STORIES: 2 HEIGHT: OCCUPANT LOAD: DATE PLANS RECEIVED BY ESGIL CORPORATION: 10/22/01 PLAN REVIEWER: Abe Doliente This plan review is limited to the technical requirements contained in the Uniform Building Code, Uniform Plumbing Code, Uniform Mechanical Code, National Electrical Code and state laws regulating energy conservation, noise attenuation and access for the disabled. This plan review is based on regulations enforced by the Building Department. You may have other corrections based on laws and ordinances enforced by the Planning Department, Engineering Department, Fire Department or other departments. Clearance from those departments may be required prior to the issuance of a building permit. Code sections cited are based on the 1997 UBC. The following items listed need clarification, modification or change. All items must be satisfied before the plans will be in conformance with the cited codes and regulations. Per Sec. 106.4.3, 1997 Uniform Building Code, the approval of the plans does not _permit the violation of any state, county or city law. To speed up the recheck process, please note on this list (or a copy) where each correction item has .been addressed, i.e., plan sheet number, specification section, etc. Be sure to enclose the marked up list when you submit the revised plans. TENANT IMPROVEMENTS WITHOUT SPECIFIC ENERGY DATA OR POLICY SUPPLEMENTS (1997UBC) tiforw.dot Carlsbad 01-3313 November 1, 2001 Please make all corrections on the original tracings, as requested in the correction list. Submit three sets of plans for commercial/industrial projects. For expeditious processing, corrected sets can be submitted in one of two ways: -· 1. Deliver all corrected sets of plans and calculations/reports directly to the City of Carlsbad Building Department, 1635 Faraday Ave., Carlsbad, CA 92008, (760) 602-2700. The City will route the plans to EsGil Corporation and the Carlsbad Planning, Engineering and Fire Departments. 2. Bring one corrected set of plans and calculations/reports to EsGil Corporation, 9320 Chesapeake Drive, Suite 208, San Diego, CA 92123, (858) 560-1468. Deliver all remaining sets of plans and calculations/reports directly to the City of Carlsbad Building Department for routing to their Planning, Engineering and Fire Departments. NOTE: Plans that are submitted directly to EsGil Corporation only will not be reviewed by the City Planning, Engineering and Fire Departments until review by EsGil Corporation is complete. 1. Plans and calculations shall be signed by the California state licensed engineer or architect where there are structural changes to existing buildings or structural additions. Please include the California license number, seal, date of license expiration and date plans are signed. Business and Professions Code. 2. The tenant space and new and/or· existing facilities serving the remodeled area must be accessible to and functional for .the physically disabled. See the attached correction sheet. Title 24. · • MISCELLANEOUS 3. Show that all doors within the one· fire rated corridor shall be 20 minute fire rated assembly. 4. Submit structural calculations for the mezzanine framing and foundation as shown on sheet S2:0. 5. Special inspection is required for all field welding and use of high strength bolts. Complete the attached city· special inspection forms. 6. Please see the following corrections for electrical, plumbing, mechanical and energy. 7. To speed up the review prbcess, note on this list (or a copy) where each correction item has been addressed, i.e., plan sheet, note or detail number, calculation page, etc. 8. Please indicate here if any changes 'have been made to the plans that are not a result of corrections from this list.· If there are other changes, please briefly describe them and where they are located in the plans. Carlsbad 01-3313 November 1, 2001 Have changes been made to the plans not resulting from this correction list? Please indicate: Yes D No D The jurisdiction has contracted with Esgil Corporation located at 9320 Chesapeake Drive, Suite 208, San Diego, California 92123; telephone number of 858/560-1468, to perform the plan review for your project. If you have any questions regarding these plan review items, please contact Abe Doliente at Esgil Corporation. Thank you. · + ELECTRICAL PLAN REVIEW + 1996 NEC + PLAN REVIEWER: MORTEZA BEHESHTI 1. Show or note on the plans the method used to limit fault currents to 10,000 amps on branch circuits. 2. Show on the single line diagram the conduit and wire sizes for the new switchboard "EDB". 3. Provide GFI protected receptacle(s) within 25 feet of HVAC equipment.-NEC 210- 8(b)2 & 210-63. 4. Provide a min.imum of 1 foot-candle of emergency illumination at the floor level and show the homerun for the lighting emergency feeders. UBC 1003.2.9.2 & NEC 700- 16. 5. Note the following requirements on the prints for panelboards supplying fire alarm equipment: Lockable cover, identified circuit breaker (red), and a breaker "lock-on" device to be installed. 6. Include the following specifications on the single line diagram when utilizing a four pole ATS: Both required signs installed at the service. NEC 700-8 (a & b). 7. If utilizing a series-rated system, note on plans: "Overcurrent device enclosures will be identified as series-rated and labeled in accordance with NEC 110-22" and " The overcurrent devices shall be AIC rated per manufacturers. labeling of the electrical equipment". Note: If you have any questions regarding this electrical plan review list please contact Morteza Beheshti at (858) 560-1468. To speed the review process, note on this list (or a copy) where the corrected items have been addressed on the plans. Carlsbad 01-3313 November 1, 2001 + PLUMBING, MECHANICAL AND ENERGY CORRECTIONS + PLAN REVIEWER: Glen Adamek 1. Each sheet of the plans must be signed by the person responsible for their preparation, even though there. are no structural changes, before the permits are issued. BLJsiness and Professions Code. 2. Detail how the floor/ceiling fire-rating is to be maintained at the recessed 2x4 light fixtures in required fire rated ceilings of rooms L 114 and L 117. 3. Show the required ceiling rated fire dampers at duct openings in the fire rated ceiling membranes. UBC, Section 713.11 #4. Correct the duct openings in the required fire rated ceilings of rooms L 114 and L 117. Also, provide sections of room showing routes of the exhaust ducts from the flammable cabinets back to the· exhaust fan. 4. Why is the fume hood being installed in the Storage Room # L 114? As per the Technical Report, dated 25 September 2001 by Eriksen-Rattan .Associates Inc. Only storage of the hazardous waste materials to be done in the rooms L 114 and L 117. No use, dispensing and/or mixing to be done in the rooms L 114 and L 117. 5. In the Technical Report, dated 25 September 2001 by Eriksen-Rattan Associates Inc. please address Where and how the pyrophorics are used to comply with UBC, Table 3-D. Butylithium, CAS# 109-72-8; Diisobutylaluminum Hydride, CAS# 1191-15-7; Triethylphosphine, CAS# 554-70-1; and Trimethyl Aluminum, CAS# 75-24-1. · 6. In the Technical Report, dated 25 September 2001 by Eriksen-Rattan Associates Inc. please address what are the 'Combustible Dust' materials being stored and where and how are the 'Combustible Dust' materials being used and address dust collection requirements. PLUMBING (1997 UNIFORM PLUMBING CODE) 7. Correct the water line sizing calculations. a) The maximum allowable friction loss per 100 feet for available design pressure of 38.0 psi and developed pipe length of 500 feet is only 7.6 psi per 100 feet. Not the 8.0 psi per 100 feet used. b) The water demands do not seem to include the demands for the deionized water system and the industrial water system. Please correct. 8. Show the required gas valves immediately preceding each gas pressure regulator, as per UPC, Section 1218.5. Carlsbad 01-3313 . November 1, 2001 9. Show each gas pressure regulator is vented to the outside. UPC, Section 1218.4 10. Clearly show the existing low pressure gas line system to be changed· to medium pressure gas system is to be tested with a 24 hour recording gas test·-· MECHANICAL (1997 UNIFORM MECHANICAL CODE) ENERGY CONSERVATION 11. Provide the complete 21 page EnergyPro 3.1 energy design package. Only 7 page on sheet M0.1 were provided. 12. On the plans clearly show the wall and roof insulation locations, thickness, and R-values, as ,per the energy design. 13. The light fixtures F8 were not included in the lighting energy design on the LTG-1 and L TG-2 forms. Please correct. 14. The Principal Envelope Designer must sign the ENV-1 form on sheet M0.1. 15. The L TG-1 forms on sheet E1 .2 must be corrected and signed by the Documentation Author and the Principal_ Lighting Designer. Note: If you have any questions regarding this plumbing, mechanical and energy plan review list please contact Glen Adamek at (858) 560-1468. To speed the review process, note on this list (or a copy) where the corrected items have been addressed on the plans. Carlsbad 01-3313 November 1, 2001 DEPARTMENT OF STATE ARCHITECT NON RESIDENTIAL TITLE 24 DISABLED ACCESS REQUIREMENTS The following disabled access items are taken from the 1998 edition of California Building Code, Title 24. Per Section 101.17.11, all publicly and privately funded public accommodations and commercial facilities shall be accessible to persons with disabilities. NOTE: All Figures and Tables referenced in this checklist are printed in the California Building Code, Title 24. • REMODELS, ADDITIONS AND REPAIRS 1. When alterations, structural repairs or modifications or additions are made to an existing building, that building, or portion of the building affected, is required to comply with all of the requirements for new buildings, per Section 11348.2. These requirements apply as follows: a) The area of specific alteration, repair or addition must comply as "new" construction. b) A primary entrance to the building and the primary path of travel to the altered area, must be shown to comply with all accessibility features. c) Existing sanitary facilities that serve the remodeled area must be shown to comply with all accessibility features. d) Existing drinking fountains (if any) must be shown to comply with all accessibility features. e) Existing public telephones (if any) must be shown to comply with all accessibility features. Carlsbad 01-3313 November 1, 2001 City of Carlscbad l=i!••Gif ,i·l•J4·Eiii,,t4,\I BUILDING DEPARTMENT NOTICE OF REQUIREMENT FOR SPECIAL INSPECTION Do Not Remove From Plans Plan Check No. 01-3313 Job Address or Legal Description 1891 Rutherford Rd Owner. ____________ ..,.,..._.Address~------------~-- y ou are hereby notified that in addition to the inspection of construction provided by the Building Department, an approved Registered Special Inspector is required to provide continuous inspection during the performance of the phases of construction indicated on the reverse ·side of this sheet. The Registered Special Inspector shall be approved by the City of Carlsbad Building Department prior to the issuance of the building permit. Special Inspectors having a current certification from the City of San Diego, Los Angeles, or ICBO are approved as Special Inspectors for the type of construction for which they are certified. The inspections by a Special Inspector do not change the requirements for inspections by personnel of the City of Carlsbad buildip.g department. The inspections by a Special Inspector are in addition to the inspections normally required by the County Building Code. The Special Inspector is not authorized to inspect and approve any work other than that for which he/she is specifically assigned to inspect. The Special Inspector is not authorized to accept alternate materials, structural changes, or any requests for plan changes. The Special Inspector is required to submit written reports to the City of Carlsbad building department of all work that he/she inspected and approved. The final inspection approval will not be given until all Special Inspection reports have been receive~ and approved by the City of Carlsbad building department. Please submit the names of the inspectors who will perform the special inspections on each of the items indicated on the reverse side of this sheet. (over) Carlsbad 01-3313 November 1, 2001 SPECIAL INSPECTION PROGRAM ADDRESS OR LEGAL DESCRIPTION: PLAN CHECK NUMBER: 01-3313_,...._,....OWNER'S NAME: I, as the owner, or agent of the owner (contractors may not employ the special inspector), certify that I, or the architect/engineer of record, will be responsible for employing the special inspector(s) as requireo by Uniform Building Code (USC) Section 1701.1 for the construction project located at the site listed above. USC Section 106.3.5. Signed ______ -'-----------'------ I, as the engineer/architect of record, certify that I have prepared the following special inspection program as required by UBC Section 106.3.5 for the construction project located at the site listed above. Signed--------------~----------- 1. List of work requiring special inspection: · D Soils Compliance Prior to Foundation Inspection D Structural Concrete Over 2500 PSI D Prestressed Concrete D Structural Masonry D Designer Specified Engtneer"s/Architect's Seal & Signature Here D Field Welding D High Strength Bolting D Expansion/Epoxy Anchors D Sprayed-On Fireproofing D Other _____ _ 2. Name{s) of individual{s) or firm{s) responsible for the special inspections listed .above: A. _______________________________ _,.... B. ---------------'-------------------,-.. C. ------------------------------------- 3. Duties of the special inspectors for the work listed above: A. B. C. Special inspectors shall check in with the City and present their credentials for approval prior to beginning work on the job site. Carlsbad 01-3313 November 1, 2001 VALUATION AND PLAN CHECK FEE JURISDICTION: Carlsbad PLAN CHECK NO.: 01-3313 PREPARED BY: Abe Doliente DATE: November 1, 2001 · BUILDING ADDRESS: 1891 Rutherford Rd BUILDING OCCUPANCY: B/S-1 TYPE OF CONSTRUCTION: 111-N .BUILDING AREA Valuation Reg. VALUE PORTION ( Sq. Ft.) Multiplier Mod. Office, lab, whse T.I. 19000 Air Conditioning Fire Sprinklers TOTAL VAL,UE Jurisdiction Code cb By Ordinance Bldg. Permit Fee by Ordinance , ,.. I Plan Check Fee by Ordinance . I ,.. I Type of Review: 0 Complete Review D Structural Only D Repetitive Fee [ERepeats Comments: D Other D Hourly ,__ ___ _.I Hour* Esgil Plan Review Fee ($) 579,999 579,999 $1,987.361 $1,291.781 $1,112.921 Sheet 1 of 1 macvalue.doc PLANNINC/ENCINEERINC APPROVALS PERMIT NUMBER CB . i0 . j b '.::> l 3 . ~· . . ADDRESS l ll9 ./ . RMJber Gt d ~ d - · · · ~-,: · "RESIDENTIAL >,;:_? t~, RESIDENTIAL ADD.ITION'..;MINOR'· < < $10,000.00) '. ' 1 '1 OTHER .PLAZA CAMINO.:!REAt.~ ; CARLSB~D. ·COMPANY STORES VILLACE, FAIRE COMPLETE OFFICE BUILDING --'--'-------------,---.,..,....------,------------ DATE_l_oi_q_.__.;;_/o-'--/ - DATE (t /1 (o I oocs/Misforms/Planning Engineering Approvals Ca.rlsbad Fire Department 013313 1635 Faraday Ave. Carlsbad, CA 92008 Plan Review Requirements Category: Fire Prevention (760) 602-4660 Dateof Report: _1_11_19_12.,...0_0_1 ___ __,.. ___ _ Building Plan Reviewed by: Name: HOR Architecture Address: 9444 Farmham St Suite 300 City, State: San Diego CA 92123 Pl'an Checker: Job#: 013313 ------- Job Name: Bldg#: CB013313 ---------,...---------------Isis Pharmace1,1ticgls Job Address: 1891. Rutherford Rd Ste. or Bldg. No. IZl Appmved LJ Approved Subject to LJ Incomplete Review FD Job# The item you have submitted for review has been approved. The approval is based on plans, information and I or specifications provided in your submittal; therefore any changes to these items after this date, including field modifications, must be reviewed by this office to insure continued conformance with applicable codes and standards. Please review carefully all comments attached as failure to comply with instructions in this report can result in suspension of permit to construct or install improvements. The item you have submitted for review has been approved subject to the attached conditions. The approval is based on plans, information and/or specifications provided in your ~ubmittal. Please review carefully all comments attached, as failure to comply with instructions in this report can result in suspension of permit to construct or install improvements. Please resubmit to this office the necessary plans and / or specifications required to indicate compliance with applicable codes and standards. The item you have submitted for review is incomplete. At this time, this office cannot adequately conduct a review to determine compliance with the applicable codes and I or standards. Please review carefully all comments attached. Please resubmit the necessary plans and I or specifications to this office for .review and approval. 1st 013313 2nd FD File# 3rd Other Agency ID CaJ:rl§.l?,ad Fire Department re~ 013313 / 16~5 Faraday Ave. Carlsbad, CA 92008 Plan Review Requirements Category: Fire Prevention (760) 602-4660 Date of Report: _11_1o_s_12_00_1 ____ ..;......._----" ..... Building Plan Reviewed by: Name: HOR Architecture ·Address: 9444 Farmham St. Suite 300 City, State: San Diego CA 92123 Plan Checker: Job#: 013313 ------- Job Name: -Isis Pharmaceuticals Bldg#: CB013313 --------.------------------=-- Job Address: 1891. Rutherford Rd .Ste.or Bldg. No. LJ Approved LJ Approved Subject to : IZI Incomplete Review FD Job# The item you have submitted for review has been approved. The approval is based on plans, information and / or specifications provided in your submittal; therefore ~my changes to these items after this date, including field modifications, must be reviewed by this office to insure continued conformance with applicable codes and standards. Please review carefully all comments attached as failure to comply with instructions in this report can result in suspension of permit to construct or install improvements. The item you have submitted for review has been approved subject to the attached conditions. The approval is based on plans, information and/or specifications provided in your submittal. Please review carefully all comments attached, as failure to comply with instructions in this report can result in suspension of permit to construct or install improvements. Please resubmit to this office the necessary plans and / or specifications required to indicate compliance with applicable codes· and standards. The item you have submitted for review is incomplete. At this time, this office cannot adequately conduct a review to determine compliance with the applicable codes and / or standards, Please review carefully all comments attached. Please resubmit the necessary plans.arid/ or specifications to this office for review and approval. 1st 013313 2nd FD File# 3rd Other Agency ID Requirements Category: -~ . Building Plan Page 1 " Requirement: Pending 05.14 Provide Technical Report To determine the acceptability oftechnologies, processes, products, facilities, materials and uses attending th(;! design, operation or use of a building or premis(;ls subject to the inspection of the department, the Chief is authorized to require the owner or the person in possession or control of the building or premises to provide, without Charge td the jurisdiction, a technical opinion and report. The opinion and report shall be prepared by a qualified engineer, specialist, laboratory or fire-safety specialty organization acceptable td the Chief and the owner and shall analyze the fire-safety properties of the design, operation or use of the building or premises and the facilities and appurtances situated thereon, to recommend necessary changes. 11/05/01 STRUCTURAL CALCULATIONS for ISIS PHARMACUTICALS, T.I. PHASE Ill 1891 RUTHERFORD CARLSBAD, CA 92008 Prepared for: HOR Architecture, Inc. 9444 Farnham Street, Suite 300 San Diego, QA 92123-1300 Prepared by DEVINE ENGINEERING, INC .. 12316 Oak Knoll Road, Suite C Poway, CA 92064 (858) 748-6168 September 19, 2001 Project #195.04 DEVINE ENGINEERING, INC. 12316 Oak Knoll· Rd., Suite C · Poway, CA 92064· (858). 748-6168 JOB· TI SHEET NO. ____________ OF _________ _ CALCUIATEDBY ..... · ~J'Yl..:.....L...;:( ______ DATE_.l ..... 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Suite C Poway, CA 92064 (858) 748-6168 Max Span in Simply Supported Beam Member Type= 1200 S 162-54 Tributary Width· ft Dead Load psf Live Load· psf E ksi I·. in4 S in3 Smax Safety Factor.' Fy· ksi Deflection U w= 0.07 kif Vmax= 0.83 It.. Deflection Lmax= 24.6 ft Moment Lmax= 24.4 ft Lmax= 24.4 ft ('1S'. 0 J SHEET-NO •. ________ OF ___ ---,-__ ~LCUlATED'BY--'l'l'f_,_, -· l, ____ DATE.__~UL.j/ ..... ':I.~/-'-' -- CHECKED BY DATE _______ _ SCALE.____ ________________ _ Allowable Stress Design .1.max= 5wL4 384EI Mmax= -wL2 8 DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd. Suite C Poway, CA 92064 (858) 7 48-6168 · Max.Span in Simply Supported Beam Member Type= 1200 S 162-54 Tributary Width· Dead Lqad· Live Load E I, s Smax Safety Factor Fy' Deflection U1~ >,.,.-. , • -·;J. ft psf psf ksi in4 in3 ksi w= 0.05 kif Vmax= 0.64 k Deflection Lmax= 28.2 ft Moment Lmax= 29.9 ft L.nax= 28~2 ft JOB I.s.;J TI /Pf .r. 0 J SHEET NO.----_______ OF __ ___,..--,--- CAi.C:UlATED sv mi l oATE._-'-'I o ..... Lr....i'l:c.+-l-=-/JI'-_ CHECKED BY DATE. _____ _ SCALE,__ ________________ _ Allowable Stress Design .6.max= 5wl4 384EI Mmax= WL2 8 DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd. Suite C Poway, CA 92064 (858) 748-6168 Max Span in Simply Supported Beam Member Type= Box Header Tributary Width ft Dead Load psf Live Load psf E ksi 1· in4 s,· in3 · Smax Safety Factor Fy ksi Deflection u w= 0.42 kif Vrriax= 1.54 kips Deflection lmax= 9.4 ft Moment Lmax:::; 7.4 ft Lmax= 7.4 ft JOB I,(iJ II /PJ[. 0) SHEET NO .. ___________ OF __ -,--~-- CALCULATED BY IY) I.. l DATE IO Ill fol I CHECKEDBY _______ DATE ______ _ SCALE. _______________ _ Allowable Stress Design ~m~= 5wL4 384EI wL2 M -max- 8 DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd. Suite C Poway, CA 92064 (858) 748-6168 Max Span in Simply Supported Beam Member Type= Box Header w= 0.44 kif V -max-1.30 kips Deflection Lmax= 8.1 ft Moment Lmax= 5.9 ft Lmax= 5.9 ft ~max= Mmax= JOB _IsiJ rr 10/SJ)J SHEET NO·-----=---,-------OF __ ---,----,-__ CALCULATED BY;....-...,_Wl..._l __ .(;...;:..' ____ DATE I 6 /'l,&1 CHECKEDBY _______ DATE. _____ _ ~ALE,__ ____________ ~---- Allowable Stress Design 5wl4 384EI wl2 8 ~Coor 1,s--1J i.,:...,-. _ _,,_--+---r-~ 6 6 $ I' l. -3) JOB_L-"-.. =s,!:,._,;__TI _______ _.,!.l---=-1/._:S:~o J DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd., Suite C Poway, CA 92064 SHEETNO.--~---------OF _________ _ CALCUtATED BY--:.m......,;(.:;...;zb _____ _ DATE__.a....{ 0_,_C...:..'!/c,__J_/ __ (858) 748-6168 CHECKED av _____________ _ DATE, ________ _ SCALE . 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Concrete fc in in in ksi Steel fy 60 ksi Astee1 0.31 in:.:/ft d 12.69 in p 0.20% w= Asxfy bxd xfc w= 0.04 Ma11= .9 xw x bx d2 x fcx (1-0.59 xw) Mau= 207.29 in-k JOB r ~l) rr I 4S.oJ SHEETNO .. ..,..· _______ OF ___ --,-__ CALCULATED BY ~l. l DATE. { () !y(OI CHECKED BY DATE. _____ _ SCALE. _______________ _ DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd. Suite C Poway, CA 92064 (858) 748...,168 Concrete Capacity For 1 ft of Slab Slab Thickness Bar Size(#) Bar Clear Dist Bar Spacing (o.c.) Concrete fc in in in ksi Steel fy 40 ksi Asteei 0.20 in.i/ft · d 12.75 in p 0.13% w= A.xfy bxd xfc w= 0.02 Mau= .9 x w x bx d2 x f'c x (1-0;59 x w) Mau= 90.86 in-k JOB . I5,'.f TI /615:0J SHEETNO. OF CALCULATED 'sy / 6 !if_ZIJI DATE tt,.L, CHECKED BY DATE SCALE I ·rr_-JOB $i5 /11 r. aJ DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd., Suite C SHEET NO. ____________ _ OF·----------- · Poway, CA 92064 (858) 748-6168 CALCULATED BY---!W,.::.!.l~l.._ _____ _ DATE-1£,-. ~c....L..-llfL.fL-6_/ __ CHECKEDBY·------------ SCALE DATE _________ _ r . . i : · ·; ····· · · .l .. --· ···+ ·--··· ·+·--·--·····1· ·--· --! ........ · !·· .. ·· ·! · ·:.·.:i-.· ··· ·r.·:.--:·.:.1.::.:--.:.:·~:~.·:···.:·.t··:·::.:1 ..... :::·:::·.·:.:·::r .. •~• :lJ·••~•r· ... : ... ·.: ..... · .. · .. ,:·: .. ::.~·. :t ·--· .. J-... ····_· ._ ..... :._ ... _ .. _ .. ;.._ ... _. ·.,;· ~_ ... _. _·· ... + ... 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PHASE Ill 1891 RUTHERFORD CARLSBAD, CA 92008 Prepared for: HOR Architecture, Inc. 9444 Farnham Street, Suite 300 San Diego, CA 92123-1300 Prepared by DEVINE ENGINEERING, INC .. 12316 Oak Knoll Road, Suite C Poway, CA 92064 (858) 748'"6168 November 12, 2001 Project #195. 03 ao13J;3 :f ·~ {J DEVINE ENGINEERING, INC. 12316 Oak-Knoll Rd., Suite C Powa), CA 92064 (858 748-6168 JOB Ls;! TI SHEET NO. ~ CALCULATED BY nu., CHECKED BY SCALE ' f ....... . ' OF DATE DATE I 'Is-. oJ . { O['.f(JI ' ····!·········,········· .... i······'·······Y· -i-········· ' ·····i·"'' -~· .. j ........ . . ···i. ···· i-····· ··t·········j ·········: ... r ...... i ...... . .. .. .. ; ...... . ! ........ ~.-... ! ....... ! ...... .. ! ; ·i ........ :.... . .. .' .... . ... . . ... : ................... , .......... ·· 1.~·. .. ... .. ... -: .. l-....... ; ..... . -!.,-· .... ; ..... . ······1 ·········(·····. ,· .. ' .... 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'!· •.. ·-··.,·· ......... : ........... ·, ..... ~-• .. .: ..................... l .. i . . r ~ . 1 . . : . .. . . ! .. ~·······-!--·--·l·······i···· ····--1 ..... , ...... ·i··· .. t···· .. L. : ' ... :· .. / ., :f DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd. Suite c · Poway, CA 92064 (858) 748-6168 Concrete Capacity For 1 ft of Slab Slab Thickness Bar Size(#) Bar Clear Dist Bar Spacing {o.c.) Concrete fc in in .... .,ksi steel·fy 60 Astee1 0.31 d 12.69 p 0.20% w= Asxfy bxd xfc w= 0.04 ksi in.!/ft in Ma11= .9 X w X b X d2 X fc X {1-0.59 X w) Mau= 207 .29 in-k JOB r ~1) rr SHEET.NO~ . "f OF ___ -__ CALCULATEDBY~J'\ll_l....,.~ _________ DATE { C /y.· / 0/ 111s.01 CHECKEDB)' _______ DATE ______ _ SCALE. _______________ _ .., ,, DEVINE ENGINEERING, INC. 123.16 Oak Knoll Rd. -Suite C Poway, CA 92064 (858) 748-6168 Cohcrete Capacity . . For 1 ft of Slab Slab Thickness Bar Size(#) Bar Clear Dist Bar Spacing (o.c.) Concrete fc Steel fy 40 ksi Asteet 0.20 in:.!lft d 12.75 in p 0.13% w= Asxfy bxd xfc w= 0.02 Mart= .9 x w x bx d2 x fc x (1-0.59 x w) Ma11= 90~86. in-k JOB I5,:r TI /6/S:OJ ID SHEET NO. OF , .. 16 tif.Zbt DATE ,S.lt CALCULATED BY . CHECKED BY DATE SCALE. J . DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd., Suite C Poway, CA 92064 (858) 748-6168 r ' f si.s TL /tS:O:J JOB ______________________ _ SHEET NO ..... ·_.... __ __..;l.:..l ______ OF ________ _ CALCULATED BY-'-·-n-J...c..-1.._& ______ DATE_~l_1.1..l4..1...s...(,..1.f __ _ CHECKED BY-...:----------DATE _______ _ SCALE . . . . ~ . . . ... l ' ' . ·.····· ·•!··· .. ·• ; ........ !""' """i'" ........ j ....... f··--··--·-+·· .. ..J. .. ·····+··· ··+·······+ ...... ·' .... · 1·--· :· ..... ·;---·· .... ; ... . ; ' : : i : . ,; .................... !.... .. :· .... ~ ........ .: ........... .i •••• ~ ••••••• .. : ...... .. !·· . ' ' . l. ... .. .I. . t . . .· ....... ., .. ' ' ' ; J. • . 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' i--_-_ .......... _ :---41 ........... 1···--·-r-······--r ..... \ .. ··i· . ·j··· ' ... i·· ···f···· .. , ········:······:. ····" ····: . ··· ,-: -· ·· ·:-.. ··t···.;-r·• !_5ff J: :rr+ *~~rT~rf Ii•l 11r·::... . ..... ·:: •· ·: · ·· .. j· --., ·----··!···--! ·· -, · · : ·· l ... , ····· ·i· . ; , , · :· ..... : ....... ; ..... ··l ·· ···+·--· :. ,. , .... · .:l.,: .. ·· .:·.:.1,.;:~~.:·:i·; ....... ;r,1,.·,.' i<: 1 .. '· . ..-):· .. r ~-·•·.!:.) i -~ 1,=;.i? -' ···· --r ' ·· r · · :· A-' 1 .· .···.,.i.; ..... · ···i. 1 ... · :·:.;·=t .. ···: .. ·, .. I l.t. · .. ·· .j. · ......... · t··· ·· .. ;.. ..T ··· ·-;--· · · · , ... ·· T · · ; . . . : .. i .. : .. r···· : .; .. "•l·--·--····t --···~·· ... i ' :rr~r-~1:r0 .L .. -;-····,····t .,. .. ' .... ! ...... ~ ....... 1 • .. ... ...... .. •... !· .•. . . L .. ... ". i .. , .... i ' · .. ·r · ·· ·r· .... · r·--··· .. r · · · ' · · (-•• · · .. ·1··· .... -i·--·. ·-. .. ..... ~.. . .. '!... • ~ .. : : : ···"t'······i······.-·····-r .. ····:······ .. ··r· ... -~---....... ; ..... ····· l · ...... ·t··· ·-·.. . ........ ! .. , .... . ) ~ ~ l . .. ~ . . ... ~ . . .. i : ..... ( ..... : ... --+ ... ·····[ ... , ;. ... •: . ... ·\····· ·y-····· L ... ' • J ., DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd. Suife C Poway, CA 92064 (858) 7 48-6168 Concrete Capacity For 1 ft of Concrete Slab Thickness in in in Bar Size(#) Bai'" Clear Dist Bar Spa¢ing (o.c.) Concretefc ksi Steel fy 40 ksi Astee1 0.20 in.!lft d 3.75 in p 0.44% w= Asxfy bxd xfc w= 0.07 Ma11= .9 XW X b X d2 X fc X (1-0.59 X W} Man= 25.87 in-k JOB Tsi!> TI /qs.01 ~t-iEETNo. ___ ~/-L ____ oF _____ _ CALCUIATED BY DATE ______ _ CHECKED BY DATE ______ _ SCA~E------'------""'------------ •{'" '. ~ -~{~----·------------------------------------~ TITLE 24 REPORT Title 24 Report for: Isis Pharmaceuticals 2292 Faraday Avenue Carlsbad, CA 92008 Project Designer: HDR Architecture, Inc. 9444 Farnham Street Suite 300 San Diego, CA 92123 (858) 712-8400 Report Prepared By: Chris Deck DEC Engineers, Inc. 9466 Black Mountain Road Suite 230 San Diego, CA 92126 (858) 578-3270 Job Number: 2147 Date: 12/17/01 The EnergyPro computer program has been used to perform the calculations summarized in this compliance report. This program has approval and is authorized by the California Energy Commission-for use with both the Residential and Nonresidential 2001 Building Energy Efficiency Standards. This program developed by Gabel Dodd/EnergySoft, LLC (415) 883-5900. EnergyPro 3.1 By EnergySoft Job Number: 2147 User Number: 5151 C/JD/ 33/J Cover Page Table of Contents TABLE OF CONTENTS Form ENV-1 Certificate of Compliance · Form ENV-2 Overall Envelope Method Form ENV-3 Proposed Construction Assembly. Form ENV-MM Envelope Mandatory Measures Form MECH-1 Certificate of Com,pliance Form MECH-2 Mechanical Equipment Summary Form Ml=CH-3 Mechanical Ventilation Form MECH-4 Mechanical Sizing and Fan Power Form MECH-MM Mechanical Mandatory Measures EnergyPro 3:1 By EnergySoft Job Number: 2147 1 2 3 5 11 12 13 15 17 18 20 User Number: 5151 icE.RTIFICATE OF COMPLIANCE Part 1 of 2 ENV-11 PROJECT NAME DATE · . _Isis Pharmaceuticals 12/17/01 PROJECT ADDRESS 2292 Faraday Avenue Carlsbad PRINCIPAL DESIGNER -ENVELOPE TELEPHONE Building Permit # HOR Architecture, Inc, (858) 712-8400 DOCUMENTATION AUTHOR DEC En ineers, Inc. TELEPHONE (858) 578,-3270 Checked by/Date Enforcement A enc Use GENERAL INFORMATION DATE OF PLANS BUILDING CONDITIONED FLOOR AREA 10-03-01 2,220 Sq.Ft. CLIMATE ZONE 7 BUILDING TYPE IX] NONRESIDENTIAL D HIGH RISE RESIDENTIAL D HOTEUMOTEL GUEST ROOM PHASE OF CONSTRUCTION . D NEW CONSTRUCTION D ADDITION IX] ALTERATION D EXISTING + ADDITION METl:iOD OF ENVELOPE COMPLIANCE D COMPONENT STATEMENT OF COMPLIANCE IX] OVERALL ENVELOPE D PERFORMANCE · This Certificate of Compliance. lists the building features and performance specifications needed to comply with Title 24, Parts 1 and 6 of the California Code of Regulations. This certificate applies only to building envelope requirements. The docurnentation preparer hereby certifies that the document is accurate and compl~te. DOCUMENTATION AUTHOR Chris Deck SIGNA _The Principal Envelope Designer hereby certifies that the propos uilding design represented in this set of constructio documents rs consistent with the other compliance forms and worksheets, with the specifications, and with any other calculations submitted with this permit application. The proposed building has been designed to meet the envelope requirements contained in Sections 11 o, 116 through 118, and 140, 142, 143 or 149 of Title 24, Part 6. Please check one: 0 I hereby affirm that I am eligible under the provisions Qf Division 3 of the Business and Professions Code to sign this document as the person responsible for its preparation; and that I am licensed in the state of California as a civil engineer or mechanical engineer, or I am a licensed architect. D .I affirm that I am eligible under the exemption to Division 3 of the Business and Professions Code by Section 5537.2 or 6737.3 to sign this document as the person responsible for its preparation;,and that I am a licensed contractor performing this work. D I affirm that I am eligible under Division 3 of the Business and Professions Code to sign this document because it pertains to a structure or type of work describ as exempt p1,.1rsuant to Business and Professions Code Sections 5537, 5538, and 6737.1. 'I M.vvt' 1-P/O~L-,A\ PRINCIPAL ENVELOPE DESIGNER -NAME HOR Architecture Inc. ENVELOPE MANDATORY MEASURES Indicate location on plans of Note Block for Mandatory Measures INSTRUCTIONS TO APPLICANT DATE/ 1z,1-:::i-01 For detailed instructions on the use of this and all Energy Efficiency Standards compliance forms, please refer to the Nonresidential Manual published by the California Energy Commission. ENV-1: Required on plans for all submittals. Part 2 may be incorporated in schedules on plans. ENV-2: Used for all submittals; choose appropriate version depending on method of envelope compliance. ENV-3: Optional. Use if default U-values are not used. Choose appropriate version for assembly U-value to be calculated. EnergyPro 3.1 By Energ Soft . User Nurriber: 9151 Job Number: 2147 Page:3 of 21 IENVELOPE COMPLIANCE-SUMMARY Part 2 of 2 ENV-11 I PROJECT NAME DATE _ Isis Pharmaceuticals 12/17/01 IOPAQUE SURFACES Solar Surface Framing Act. Gains # Type Type Area U-Fac -Azm. Tilt Y/N Form 3 Reference Location / Comments 1 Roof None 495 0.048 0 0 X Buiit uo Roof w/R-19 @ cla. Conference 2 Wali' Metal 648 0.135 0 90 X 8" cone. wall w/R-11 metal studs Office 3 Wall Metal 396 . 0.135. 90 90 X 8" cone. wall w/R-11, metal studs Office 4 Roof None 1,725 0:048 0 0 X Built UP Roof w/R-19 @ CIQ. .Office .. FENESTRATION SURFACES . . . . .. Site Assembled Glazing O Check box If BUIiding IS>= 100,000 sqft o_f CFA and>= 10,000 sqft vertical glazing then NFRC Cert1fIcatIon Is required . Follow NFRC 100 SB Procedures and submit NFRC Label Certificate Form - # Type Area U-Fac. Act.Azm. SHGC Glazing Type Location / Comments .. EXTERIOR SHADING Window Overhang Left Fin Right Fin # ·Exterior Shade Type SHGC Hgt. Wd. Len. Hat. LExt.RExt. Dist. Len. Hat. Dist. Len. Hat. . - .. EnergyPro 3.1 By EnergySoft User Number: 5151 Job Number: 2147 Page:4of 21 ~ (OVERALL EN\IELOPE METHOD Part 1 of 6 ENV-21 PROJECT NAME DATE Isis Pharmaceuticals 12/17/01 IWINDOWAREA TEST A. DISPLAY PERIMETER ._I -~---_c..,ol ft X 6 = .__ ____ ____c.,d sf DISPLAY AREA B. GROSS EXT!=RIOR WALL AREA ,_/ ____ 1 ~,0_4~4/ sf X 0.40 = ~----4_1~§ sf 40% AREA C. GROSS EXTERIORWALL AREA ·._/ ____ 1~,0_4~41 sf X0.10= ._I ____ 1_0~~ sf MINIMUMSTND.AREA D. ENTER LARGER OF A or B E. ENTER PROPOSED WINDOW AREA ~-----4_1 §~ sf MAXIMUM STND. AREA ~------d~ sf PROPOSED AREA F. WINDOW WALL RATIO = Proposed Window Area Divided by Gross Exterior Wall.Area= 0.00%1 IF EIS GREATER THAN D OR LESS THAN C, PROCEED TO THE NEXT CALCULATION FOR THE WINDOW AREA ADJUSTMENT. IF NOT, GO TO PART 2 OF 6. 1. IF E GREATER THAN D: MAXIMUM STANDARD AREA .:. • PROPOSED WINDOW AREA WINDOW ADJUSTMENT FACTOR GO TO PART 6 TO CALCULATE ADJUSTED AREAS. 2. IF LESS THAN C: MINIMUM PROPOSED STANDARD AREA AREA '. 1041 + ~---~11 WINDOW ADJUSTMENT FACTOR o.oool GO TO PART 6 TO CALCULATE ADJUSTED AREAS. I SKYLIGHT AREA JEST ATRIUM HEIGHT ,. 9[ FT ' '---,--i --.,=-,i ------IF<= 55 FT IF> 55 FT I C:1 o.1olx ~I --~I=~-~ ~--0_.0~5' X I 2,2201 = 111r----1 STANDARD % GROSS STANDARD ROOF AREA SKYLIGHT AREA PROPOSED SKYLIGHT AREA IF THE PROPOSED SKYLIGHT AREA IS GREATER THAN THE STANDARD SKYLIGHT AREA, PROCEED TO·THE NEXT CALCULATION FOR THE SKYLIGHT AREA ADJUSTMENT. IF NOT, GO TO PART 2 OF 6. 1. IF PROPOSED SKYLIGHT AREA>= STANDARD SKYLIGHT AREA: STANDARD $KYLIGHT AREA PROPOSED SKYLI.GHT AREA SKYLIGHT ADJUSTMENT FACTOR . --:-,·'----------~ -'-----'---------' GO TO PA~T 6 TO·CAlCULATE ADJUSTED AREAS. EnergyPro 3.1 By EnergySoft User Number: .5151 Job Number: 2147 Page:5 of 21 IOVERALL ENVELOPE METHOD Part 2 of 6 ENV-2 ( PROJECT NAME DATE Isis Pharmaceuticals 12/17/01 OVERALL HEAT LOSS 0 [!] @] @] ~ 0 @] ~ PROPOSED STANDARD TABLE ASSEMBLY NAME HEAT u-VALUES UA AREA* UA (e.g. Wall-1, Floor-i) AREA CAPACITY FACTOR y N (BXD) (Adjusted) U-FACTOR (FX G) Built up Roof w/R-19 @ clg. 495 1.23 0.048 D [Z] 23.8 495 0.07~ 38.6 NWall 648 15.47 0.135 [Z] D 87.8 583 0.69( 402.4 10% Glazing Allotment 0 0.000 D [Z] 0.0 65 0.81( 52.5 EWall 396 15.47 0.135 lZJ D 53.7 356 0.69( 245.9 10% Glazing Al_lotment 0 0.000 D _[Z] 0.0 40 0.81< 32.1 .. Built up Roof w/R-19 @ clg. 1,725 1.23 0.048 D [Z] 82.9 1,725 O.O?f 134.6 D -D D D D D D D . D D D D D D D D D D 0 D D 0 D 0 ' D D D D D D D D D D D D· D D D D D D D D D D ' D D * If Window and/or Skylight Area Adjustment is Required, Column E shall be B This Page Total B use Adjusted Areas from Part 6 of 6. no greater than -Column H 8 Building Total 6 EnergyPro 3.1 By EnergySoft User.Number: 5151 Job Numper: 2147 Page:6of 21 ;, I OVERALL ENVELOPE METHOD Part 3 of 6 ENV-21 PROJECT NAME /DATE Isis Pharmaceuticals 12/17/01 nvERALL HEAT GAIN FROM CONDUCTION 0 ~ @] @] ~ 0 @] 0 OJ Q] PROPO~ED STANDARD TABLE HEAT HEAT ASSEMBLY NAME HEAT u-VALUES GAIN AREA* U-GAIN Q Q (~.g. Wall-1, Floor-1) AREA TF CAPACITY FACTOR y N (BxCxE) (Adjusted) FACTOR TF <GxHxl) ~uilt up Roofw/R-19@ clg. 49 5 27 1.23 0.04 80 [Z] 642 495 0.07 8 27 1,042 NWall 64 8 15 15.47 9.135 00 D 1,317 583 0.69 0 15 6,036 10% Glazing Allotment 0 27 0.000 D [Z] 0 65 0.810 27 1,417 EWall 396 15 15.47 0.135 00 D 805 356 0.690 15 3,689 10% Glazing Allotment 0.27 0.000 D [Z] 0 40 0.810 27 866 Built up Roof w/R-19 @ clg. 1,725 27 1.23 0.048 0 [Z] 2,239 1,725 0.078 27 3,633 D D D D D D .. D D D D .. D D -. D D D D D D D D D D D D .. [j D D D D D D D D D D D D D D D D D D D D D D D * If Window and/or Skylight Area Adjustment is Required, I 5,003/ I 16,6831 use Adjusted Areas from Part 6 of 6. Subtotal Subtotal I I EnergyPro 3.1 By EnergySoft User Number: 5151 Job Number: 2147 Page:7of 21 IOVERALL ENVELOPE METHOD . PROJECT NAME . Isis Pharmaceuticals IOVERALL HEAT GAIN FROM RADIATION OPAQUE SURFACES PROPOSED ~SSEMBL Y NAME WEIGHTING u-HEAT GAIN ~e.g. Roof-1) AREA SF FACTOR FACTOR Absorp (BxCxDxExF) Built un Roof w/R-19 @ cla. 49!: 123 0.87 0.048 0.70 1 782 . Built un Roofw/R-19@ cla. 1 72!: 123 0.87 0.048 0.70 6212 7,9941 SUBTOTAL EnergyPro 3.1 By EnergyPro User Number: 5151 Job Number: 2147 Part 4 of 6 ENV-2( AREA* (ADJUSTED) 495. 1 725 DATE 12/17/01 OJ 0 STANDARD HEAT GAIN U-Factor Absorp (CxDxHxlxJ) 0.078 0.70 0.078 0.70 2892 10079 12,9711 SUBTOTAL Page:8 of 21 IOVERALL ENVELOPE METHOD Part 5 of 6 ENV-2·1 PROJECT NAME DATE Isis Pharmaceuticals 12/17/01 IOVERALL HEAT GAIN FROM RADIATION FENESTRATION SURFACES 0 C!J @J @J[f] 0 @JIB] OJ 0 ,-------~-----------,,----------------, PROPOSED STANDARD !WINDOW/SKYLIGHT NAME WEIGHTING OVERHANG !-1EA1 GAIN AREA* RSHG ~e.g. Wind-1, Sky,1) ORIENT. FACTOR AREA SF SHGC H V HN OHF (BxCxDxExH) (ADJUSTED) (or SHGC**) SF HEAT GAIN Q (BxJxKxL) 10.% Glazina Allotment N 10% Glazina Allotment E , *If Window ahd/or Skylight Area · Adjustment is Required, use . Adjusted.Areas from Part 6 of 6. EnergyPro 3.1 By EnergySoft 0.57 _c 123 o.oo 0.97 c 123 o.oo ** Only SHGC is used for Skylights Column I must be less than column. M User Number: 5151 0 0 Part 3 Subtotal j 5,0031 ::::=======~ Part 4 Subtotal ;::I =====7=,9=94:::;J Part 5 Subtotal ::I =======o::::I I 12.9971 Job Number: 2147 65 40 0.61 123 2771 0.61 123 2,882 Part 3 Subtotal I 16,6831 Part 4 Subtotal ;::J ===1=2,=97:::;11 Part 5 Subtota ... 1::;l ~_-___ 5-=.,6=5::;31 Total Heat Gain 35,3081 Page:9 of 21 I IOVE.RALL ENVELOPE METHOD Part 6 of 6 ENV-21 PROJECTNAME DATE Isis Pharmaceuticals 12/17/01 WINDOW AREA ADJUSTMENT CALCULATIONS [XI CHECK IF NOT APPLICABLE (See Part 1 of 6.) [§] 0 @] EJ ~ @] @J WINDOW ADJUSTED ADJUSTED ADJUST. WINDOW WALL WALL NAME · I ORIENTATION GROSS DOOR WINDOW FACTOR AREA AREA (e.g. Wall-1, Wall-2) IN IE Is I w I AREA AREA AREA (From Part 1) (DX E) B-(F + C) --DODD DODD DODD DODD DODO DODD DODD DODD DODD ' DODD DODD DODD DODD DODD -DODD DODD DODD DODD I TOTALS I I I I I NIAi I I !SKYLIGHT .u:u::4 A.n.llJSTMENT ~41 ~I II ATIOtJ~ [xj CHECK IF NOT APPLICABLE (See Part 1 of 5.) @] [[] [I] 0 ~ @] SKYLIGHT ADJUSTED ADJUSTED ADJUST. SKYLIGHT ROOF ROOFNAME GROSS SKYLIGHT FACTOR AREA AREA (e.g. Roof-1, Roof-2) AREA AREA (From Part 1) (CX D) (B-E) I TOTALS 11 I I NIAi I I EnergyPro 3.1 By EnergySoft User Number 5151 Job Number: 2147 Page:1 O of 21 . ' .IPROPOSED CONSTBUCTION ASSEMBL y ENV-31 PROJECT NAME DATE Isis Pharmaceuticals 12/17/01 COMPONENT DESCRIPTION ASSEMBLY NAME lsuilt u12 Roofw/R-19@ clg. I ASSEMBLY ~ Floo, TYPE Wall (check one) w Ceiling/Roof C w en C FRAMING MATE;RIAL I None! I-en ::::, z 0 FRAMING% I !% Framing% 15% (16" o.c. Wall) 12% (24" o.c. Wall) 10% (16" o.c. Floor/Ceil.) SKETCH OF ASSEMBLY 7% (24" o.c. Floor/Ceil.) CONSTRUCTION COMPONENTS ~ ~ A-VALUE *HEAT CAPACITY (Optional) THICK-CAVITY WOOD WALL SPECIFIC HC .. NESS R,VALUE FRAME WEIGHT HEAT (AXB) DESCRIPTION FRAMING (in.) (Re) A-VALUE (lbs/sf) (Btu/F-lb) (Btu/F-sf) OUTSIDE SURFACE AIR FILM -0.170 --- 1 Plywood D 0.500 0.620 1.42 0.29 0.41 2 Roofing, Built-Up D 0.375 0.330 2.19 0.35 0.77 3 lnsul_ation, Mineral Fiber, R-19 D 6.000 19.002 0.30 0.17 0.05 4 D 5 D 6 O, 7 D 8 D 9 D INSIDE SURFACE AIR FILM -0.680 --- $UBTOTAY 20.801 II 3.91 TOTALHC I 1.21 Re Rf *NOTE: Weiaht and Soecific Heat values for materials oenetrated by wood framina include the effects of the framina members. [! D Li TI I X I + I X I = I 0.048 I 1 /Re 1 -(Fr%/ 100) 1 / Rf Fr%/100 ASSEMBLY U-VALUE COMMENTS EnergyPro 3.1 By EnergySoft User Number: :5151 Job Number: 2147 Page:11 of 21 IENVELOPE MANDATORY MEASURES ENV-MMf PROJECT NAME DATE Isis Pharmaceuticals 12/17/01 Dt=SCRIPTION Designer Enforcement D §118(a) Installed Insulating Material shall have been.certified by the manufacturer to comply with the California Quality Standards for insulating material, Title 20, Chapter 4, Article 3. D § 118(c) All Insulating Materials shall be installed in compliance with the flame spread rating ·and-smoke density requirements of Sections 2602 and 707 of Title 24, Part 2. D § 117(a) All Exterior Joints and openings in the building that are observable sources of air leakage shall be caulked, gasketed, weatherstripped or otherwise sealed. D § 116(b) Site Constructed Doors, Windows and Skylights shall be caulked between the unit and the building, and shall be weatherstripped (except for unframed glass doors and fire doors). D § 116(a)1 Manufactured Doors and Windows installed shall have air infiltration rates not exceeding those shown in Table Number 1-E. of the Standards. Manufactured fenestration products must be labeled for U-value according to NFRC procedures. D § 118(e) Demising Walls in Nonresidential Buildings: The opaque portions of framed demising walls.in nonresidential buildings shall have insulation with an installed R-value of no less.than R-11 between framing members. EriergyPro 3.1 By EnergySoft Us!3r Number: 5151 Job Number: 2147 Page:12 of 21 lcERTIFICATE OF COMPLIANCE Part 1 of 2 MECH-11 PROJECT NAME DATE Isis Pharmaceuticals 12/17/01 PROJECT ADDRESS 2292 Faraday Avenue Carlsbad Building Permit# PRINCIPAL DESIGNER· MECHANICAL TELEPHONE Deck Engineering Consultants, Inc. (858) 578-3270 DOCUMENTATION AUTHOR TELEPHONE Checked by/Date OEC Engineers, Inc. (858) 578-3270 Enforcement Agency Use . GENERAL INFORMATION DATE OF PLANS ./ BUILDING CONDITIONED FLOOR A.REA 10-03-01/ 2,220sq.Ft. BUILDING TYPE [X] NONRESIDENTIAL D HIGH RISE RESIDENTIAL D HOTEL/MOTEL GUEST ROOM PHASE OF CON$TRUCTION D NEW CONSTRUCTION D ADDITIO~ !Xl ALTERATION D EXISTING + ADDITION METHOD OF MECHANICAL [X] PRESCRIPTIVE O PERFORMANCE COMPLIANC.1; PROOF OF ENVELOPE COMPLIANCE D PREVIOUS ENVELOPE .PERMIT D ENVELOPE COMPLIANCE ATTACHED STATEMENT OF COMPLIANCE This Certificate of Compliance lists the building features and performance specifications needed to comply with_ Title 24, Parts. 1 and 6 of the California Code of Regulations. This certificate applies only to building mechanical requirements. The documentation prepl:lrer hereby certifies that the document~'5 s accur r -· :)Omplete. DOCUMENTATIONAUTHOR ISIGNATi RE I L. IDAT~ l Chris Deck I I~ lni ~ i'-1171~1 The Principal Mechanical Designer hereby certifies that the prop~ d building aesign represented in this set of construction documents is consistent with the other compliance forms and worksheets, with the specifications, and with any other calculations submitted with this permit application. The proposed building has been designed to meet the mechanical requirements contained in Sections 110 through115, 120 through 124, 140 through 142, 144 and 145. Please check one: Vi hereby affirm that I am eligible under the provisions of Division 3 of the Business and Professions Code to sign this ~ocument as the person responsible for its. preparation; and that I am licensed in the State of California as a civil engineer, or mechanical engineer or I am a licensed architect. D i affirm that I am eligible under the exemption to Division 3 of the Business and Professions Code by Section 5537.2 or 6737.3 to sign this document as the person responsible for its preparation; and that I am a licensed contractor performing this work. D ·1 affirm that I am eligible under the exemption to Division 3 of the Business and Professions Code to sign this document because it pertains to a structure or type of work described .pursuant to Business and Professions Code sections 5537, 5538; and 6737.1. ~'--_..,.r\, _ _..,. ___ -.---------,-------1 PRINCIPAL MECHANICAL DESIGNER -NAME I SIGN4 rru ri..·~~ IDATE -_ 1 ILIC. # Deck Enaineerina Consultants Inc. I l a.K . li/t 7 tr;I ic-t 3oor7 MECHANICAL MANDATORY .MEASURES - Indicate location on plans of Note Block for Mandatory Measures INSTRUCTIONS TO APPLICANT _ For detailed instructions on the use of this and all Enl;lrgy Effici·ency Standards compliance forms, please refer to the Nonresidential Manual published by the California Energy Commission. MECH-1: Required on plans for all submittals. Parts 2 may be incorporated in schedules on plans. MECH-2: Required for all submittals, but form does not have to be completed if location of mechanical equipment schedule is indicated on the form per Section 4.3.3. MECH-3: Required for all submittals unless required outdoorvehtilation rates and airflows are shown on plans per Section 4.3.4. MECH-4: Required for Prescriptive submittals. MECH-5: Ootional. Performance use onlv for mechanical distribution summarv. EnergyPro 3. 1 By EnergySoft User Numb~r: 5151 Job Number: 2147 Page:13 of 21 !CERTIFICATE OF COMPLIANCE Part 2 of 2 MECH-1 f PROJECT NAME DATE 'Isis Pharmaceuticals 12/17/01 !SYSTEM FEATURES ~-------------'I !-~----~~-' MECHANICAL SYSTEMS jsYSTEMNAME . _ HP-1 I I, HP-2 I ~I -----~ NOTE TO flELD_ TIME CONTROL Programmable Switch Programmable Switch SETBACK CONTROL Heatin Re uired Heatina Reauired ISOLATION ZONES n/a n/a HEAT PUMP THERMOSTAT? n/a n/a ELECTRIC HEAT? n/a n/a FAN CONTROL Constant Volume Constant Volume VAV MINIMUM POSITION CONTROL? No No SIMULTANEOUS HEAT/COOL? . No No HEATING SUPPLY RESET Constant Tern Constant Terna COOLING SUPPLY RESET Constant Tern Constant Temp HEAT REJECTION CONTROL n/a n/a VENTILATION Air Balance Air Balance OUTDOOR DAMPER CONTROL Auto Auto ECONOMIZER TYPE No Economizer. No Economizer DESIGN AIR CFM (MECH-3, COLUMN I) 371 cfm 259 cfm HEATING EQUIPMENT TYPE Gas Furnace Gas Furnace HEATING EQUIPMENT EFFiCIENCY 81%AFUE 81% AFUE COOLING EQUIPMENT TYPE Packa ed DX Packaged DX COOLING EQUIPMENT EFFICIENCY 10.0 SEER/ 8.7 EER 10.0 SEER/ 8.5 EER MAKE AND MODEL NUMBER 3 Ton Heat Pump 5 Ton HearPump HEATING DUCT LOCATION R·VALUE Ducts·inAttic 4.2 Ducts in Attic 4.2 COOLING DUCT LOCATION R-VALUE Ducts in Attic 4.2 Ducts in Attic 4.2 PIPE/DUCT INSULATION PROTECTED? No No PIPE TYPE (SUPPLY, RETURN, ETC.) PIPE INSULATION REQUIRED? No No· VERIFIED SEALED DUCTS IN CEILING/ROOF SPACE No No CODE TABLES: Enter code from table below into columns above. - HEAT PUMP THERMOSTAT? TIME CONTROL SETBACK CTRL. ISOLATION ZONES FAN CONTROL ELECTRIC HEAT? S: Prog. Switch H: Heating Enter Number of I: Inlet Vanes O: Occupancy C: Cooling Isolation Zones. P: Variable Pitch VAV MINIMUM POSITION CONTROL? Sensor 8: Both V:VFD SIMULTANEOUS HEAT/ COOL? Y:Yes M: Manual Timer 0: Other C: Curve N:No HEAT AND COOL SUPPLY RESET? VENTILATION OUTDOOR DAMPER ECONOMIZER O.A.CFM HIGH EFFICIENCY? B: Air Balance A: Auto A:Air Enter Outdoor Air PIPE INSULATION REQUIRED? C: Outside Air Cert. G: Gravity W: Water CFM. M: Out. Air Measure N: Not Required Note: This shall be no PIPE/DUCT INSULATION PRQTECTED? D: Demand Control EC: Economizer less than Col. H on N: Nat1,1ral Control See Section MECH-3. SEALED DUCTS IN CEILING/ROOF SPACE? 144(e)3 [NOTES TO El~Ll2" For Budding Department Use QnlY EnergyPro 3.1 By EnergySoft User Number: 5151 . Job Number: 2147 Page:14 of 21 IMECHANICAL EQUIPMENT SUMMARY Part 1 of 2 MECH-2l PROJECT NAME !DATE 12/17/01 Isis Pharmaceuticals CHILLER AND Tuvv ..... SUMMARY PUMPS Tot. Motor Drive Pump Equipmeni Name Equipment Type Qty. Effi~iency Tons Qty_ GPM BHP Eff. Eff. Control DHW / ROILl=R ~III\IIMARY Energy Factor Standby TANKINSUL. Rated Vol. or Recovery Loss or Ext. System Naine System Type Distribution Type Qty 'Input (Gals.) Efficiency Pilot R-Val. CENTRAL SYSTEM RATINGS HEATING COOLING Aux. Svstem Name Svstem TvnA Qtv. Outout kW Eff. Outout Sensible Efficiencv Economizer Type 3 Ton Heat Pump Packaged DX 1 46,930 0.0 81%AFUE 36,000 25,200 10.0 SEER/ 8.7 EER No Economizer 5 Ton f'ieat Pump Packaged DX 1 77,140 0.0 81%AFUE 59,500 41,65( 10.0 SEER/ 8.5 EER No Economizer CENTRAL SYSTEM FAN SUMMARY - _ SOPPLYFAN RETURN FAN Motor Drive Motor Drive Svstem-Name FanTvoe Motor Location CFM BHP Eff. Eff. CFM BHP Eff. Eff. . 3Ton Heat Rump Constant Volume Blow-through 1,200 0.50 77.0% 100.0% . none 5 Ton Heat Pump Constant Volume Blow-Through 1,995 1.00 82.5% 100.0% -none Energypro 3.1 -By EnergySoft _ User Number: 5151 Job Number: 2147 Page:15 of 21 IMECHANICAL EQUIPMENT SUMMARY Part 2 of 2 MECH-21 PROJECT NAME Isis Pharmaceuticals IDATE 12/17/01 ZONE TERMINAL SUMMARY VAV TERMINAL BOX TERMI~ AL F4111 Min. CFM . Dchooo+ ,..,..;1 Motor Drive Svstem Tvoe Qtv. Ratio Tvoe DeltaT CFM BHP Eff. Eff. Type Output i-=cC=on=fe=r=en=c=e-----~-1 i--:V-'--A=V--=B=o=x __ -------jf-----'1+------'1-"-00-'--'o/c-10"'""no=n=e--+-""""'n"-=l/a none none n/a Office VAV Box 1 100¾ none .n/a none 1-------+--'---+---------t---< none n/a EXHAUST FAN SUMMARY EXHAUST FAN EXHAUST FAN Motor Drive Motor Drive Room.Name Qtv. CFM BHP Eff. Eff. Rooin Name Qty. CFM BHP Eff. Eff. EnergyPro· 3.1 By EnergySoft User Number: 5151 Job Numb.er: 2147 Page:16 of ~1 IMECHANICAL VENTILATION MECH-31 PROJECT NAME DATE Isis Pharmaceuticals 12/17/01 IMECHANICAL VENTILATION Q] -AREA BASIS OCCUPANCY BASIS REQ'D DESIGN COND. MIN. NO. CFM MIN. O.A. OUTDOOF VAV :J'RANS ZONE/SYSTEM AREA CFM CFM OF PER CFM (MAX OF AIR MIN. FER (SF) PER SF (B xC) PEOPL EPERSON (ExF) DORG) CFM RATIO AIR - Conference 495 0.50 248 248 371 100% - HP-1 Total 248 371 -Office 1,725 0.15 259 259 259 100% -HP-2 Total 259 259 - - - - '--- '--- - -- - - '--- - - - '--- - - - '--- -- - -- - ~ Minimum Ventilation Rate per Section 121, Table 1-F. Based _on Expected Number of Occupants or at least 50% of Chapter 1 o 1997 USC Occupant Density. Must be greater than or equal to H, or use Transfer Air. Design Outdoor Air includes ventilation from Supply Air System & Room Exhaust Fans. , Must be greater than or equal to (H minus I), and, for VAV, greater than or equal to (H-J). , EnergyPro 3.1 By EnergySoft User Number: 5151 Job Number: 2147 Page:17 of 21 !MECHANICAL SIZING AND FAN PClWER MECH-41 PROJECT NAME . DATE Isis Pharmaceuticals 12/17/01 SYSTEM NAME FLOOR AREA HP-1 495 NOTE: Provide one copy of this form for eacli mechanical system when using the Prescriptive Approach. !SIZING AND EQUIPMENT SELECTION 1. DESIGN CONDITIONS: • OUTDOOR DRY BULB TEMPERATURE • OUTDOOR WET BULB TEMPERATURE • INDOOR, DRY BULB TEMPERATURE 2. SIZING: • DESIGN OUTDOOR AIR -ROOM LOADS • RETURN VENTED LIGHTING • RETURN AIR DUCTS • RETURN FAN • SUPPLYFAN • SUPPLY DUCTS (APPENDIX C) (APPENDIX C) SEE ASHRAE CHAPTER 8, 1993 OR APPENDIX B ~ ___ 3_7~11 CFM (MECH 3; COLUMN I) TOTALS SAFETY /WARM-UP FACTOR MAXIMUM ADJUSTED LOAD (TOTALS FROM ABOVE lCSAFETY /WARM-UP FACTOR) 3. SELECTION: INSTALLED EQUIPMENT CAPACITY (ADJUSTED FOR DESIGN· CONDITIONS) IF INSTALLED CAPACITY EXCEEDS MAXIMUM ADJUSTED LOAD, EXPLAIN FAN POWER CONSUMPTION [KJ []] @] @J [I] DESIGN EFFICIENCY NUMBER FAN DESCRIPTIQN BRAKE.HP MOTOR DRIVE OFF.ANS Supply Fan 0.500 77.0% 100.0% 1 COOLING ~ 9( OF OF 72 72 6 310 14,942 1,774 747 0 1,653 747 26,1841 1.21 31,682 26,8671 Btu/ Hr [£] OF OF PEAK WATTS Bx Ex 746 / (C X D 484 70l°F 14 957 90 -1,65 45 14,2981 1.43 20,447 46,9301 Btu/ Hr @] CFM (Supply Fans) 1,200 NOTE: Include only fan systems exceeding 25 HP (see Section 144). TOTALS I 48411 122001 Total Fan System Power Demand may not exceed 0;8 Watts/cfm for TOTAL FAN SYSTEM I 0.4041 constant volume systems or 1.25 Watts/cfm for VAV systems. POWER DEMAND WATTS/CFM Col. F / Col. G EnergyPro 3.1 By EnergySoft Ui;;er Numb~r 5151 Job Number: 2147 Page:18 of 21 . IM.ECHANICAL SIZING AND FAN POWER MECH-4f PROJECT NAME DATE Isis Pharmaceuticals 12/17/01 SYSTEI\II NAME FLOOR AREA HP-2 1,725 NOTE: Provide one copy of this form for each mechanical system when using the Prescriptive Approach. ISIZING AND EQUIPMENT SELECTION 1. DESIGN CONDITIONS: -OUTDOOR DRY BULB TEMPERATURE • OUTDOOR WET BULB TEMPERATURE -INDOOR, DRY BULB TEMPERATURE 2. SIZING: -DESIGN OUTDOOR AIR -ROOM LOADS -RETURN VENTED LIGHTING -RETURN AIR DUCTS -RETURN FAN -SUPPLY FAN • SUPPLY DUCTS (APPENDIX C) (APPENDIX C) SEE ASHRAE CHAPTER 8, 1993 OR APPENDIX B '--__ 2_5-'--9--'-'I CFM (MECH 3; COLUMN I) TOTALS SAFETY /WARM-UP FACTOR MAXIMUM ADJUSTED LOAD (TOTALS FROM ABOVE x SAFETY /WARM-UP FACTOR) 3. SELECTION: INSTALLED EQUIPMENT CAPACITY (ADJUSTED FOR DESIGN CONDITIONS) IF iNSTALLED CAPACITY EXCEEDS MAXIMUM ADJUSTED LOAD, EXPLAIN FAN POWER CONSUMPTION 0 [!] @] [[] [I] .. DESIGN EFFICIENCY NUMBER FAN DESCRIPTION BRAKE HP MOTOR DRIVE OF FANS Supply Fan 1.000 82.5% 100.0% 1 -I COOLING ~ 9( OF OF 72 72 3 867 30,699 5,358 1,535 0 3,086 1,535 46,0801 1.21 55,757 45,4221 Btu /Hr [I] OF OF PEAK WATTS Bx Ex 746 / (C X D 904 10J°F n/ 42 -3,08 42 16,6721 1.43 23,841 77,1401 Btu/ Hr @] CFM (Supply Fans) 1,995 NOTE: Include only fan systems exceeding 25 HP (see Section 144). TOTALS I 90411 1!9951 Total Fan System Power Demand may not exceed 0.8 Watts/cfm for TOTAL FAN SYSTEM I 0.4531 constant volume systems or 1.25 Watts/cfm for VAV systems. POWER DEMAND WATTS/CFM Col. F / Col. G Energy,Pro.3.1 ,By EnergySoft User Number 5151 Job Num_ber: 2147 Page:19 of 21 ' fME'CHANICAL MANDATORY MEASURES Part 1 of 2 MECH-MMI PROJECT NAME DATE Isis Pharmaceuticals 12/17/01 DESC.RIPTION Designer Enforcement Eq1,1ipment and Systems Efficiencies D § 111 Any appliance for which there is a California standard established in the Appliance Efficiency Regulations will comply with the applicable standard. D § 115(a) Fan type central furnaces shall not have a pilot light. D § 123 Piping, except that conveying fluids at temperatures between 60 and 105 degrees Fahrenheit, or within. HVAC equipment, shall be insulated in accordance with Standards Section 123. D § 124 Air handling duct systems shall be installed and insulated in compliance with Sections 601, 603 and 604 of the Uniform Mechanical Code. Controls § 122(e) Each space conditioning system shall be.installed with one of the following: D § 122(e)1A Each space conditioning system serving building types such as offices and manufacturing facilities {and all others not explicitly extimpt from the requirements of Section 1-12 (d)) shall be installed with an automatic time switch with an accessible manual override that allows operation of the system during off-hours for up to 4 hours. The time switch shall be capable of programming different schedules for weekdays and weekends; incorporate an automatic holiday "shut- off" feature that turns off all .loads for at least 24 hours, then resumes the normally scheduled operation; and has program backup capabilities that prevent the loss of the device's program and time setting for at least 10 hours if power is interrupted; or D .§ 122(e)1B An occupancy sensor to control the operating period of the system; or D § 122(e)1C A 4-hourtimer that-can be manually operated to control the operating period of the system. D § 122(e)2 Each space conditioning system shall be installed with controls that temporarily restart and temporarily operate-the system as required to maintain.a setback heating and/or a setup cooling thermostat setpoint. D § 122{g) Each space cpnditioning system serving multiple zones-with a combined conditioned floor area more than 25,000 square feet shall be provided with isolation zones. Each zone: -shall not exceed 25,000 square feet; shall be provided with isolation devices, such as valves or da.mpers, that allow the supply of heating or cooling to be setback or shut off independently of other isolation areas; and shall .be controlled by a time control ~twice as-described above. D § 122(a&b) Each space conditioning system shall be controlled by an individual thermostat that responds to temperature within the zone. Where used to control heating, the control shall be adjustable down to 55 degrees For lower. For cooling, the control shall be adjustable up to 85 degrees For higher. Where used for both heating and cooling, the control shall be c;apable of providing-a deadband of .at least 5 degrees F within which the supply of heating and cooling is shut off or reduced to a minimum. D § 122(c) Thermostats shall have numeric setpoints in degrees Fahrenheit {F) and adjustable setpoint stops accessible only to authorized personnel. D § 112(b) Heat pumps shall be im~talled with controls to prevent electric resistance supplementary heater operation when the heating load can be met by the heat pump alone. EnergyPro ;3.1 By EnergySott User Number: 5151 Job Number: 2147 Page:20 of 21 4 • • jMEC.;ANICAL MANDATORY MEASURES Part 2 of 2 MECH-MMI PROJECT NAME DATE Isis Pharmaceuticals 12/17/01 _ Description Designer Enforcement Ventilation D § 121(e) Controls shall be provided to allow outside.air dampers or devices to be operated at the ventilation rates as specified-on these plans. D § 1?2(f) Gravity or automatic dampers interlocked and closed on fan shutdown shall be provided on the outside air intakes and discharges of all space conditioning and exhaust systems. D § 122(f) All gravity ventilating systems shall b~ provided with automatic or readily accessible manually operated dampers in all openings to the outside, except for combustion air openings. ·o § 121(f)1 Air Balancing: The system shall be balanced in accordance with the National Environmental Balancing Bureau (NEBB) Procedural Standards (1983), or Associated Air Balance Council (AABC) National Standards.(1989); or D § 121(f)2 Outside Air Certification: The system shall provide-the minimum outside air as shown on the-mechanical drawings, and shall be measured and certified by the installing licensed C-20 mechanical contractor and certified by (1) the design mechanical engineer, (2) the installing licenced C-20 mechanical contractor, or (3) the person with overall responsibility for the design of the ventilation system; or D § 121(f)3 Outside Air Measurement: The system shall be equipped with a calibrated local or remote device capable of measuring the quantity of outside air on a continuous basis and displaying that quantity on a readily accessible display divice; or D § 121(f)4 Another method approved-by the Commission. Service Water Heating Systems D § 113(b)2 If a circulating hot water system is installed, it shall have a control capable of automatjcally turning off the circulating pump(s) when hot water is not required. D § 113(b)3B Lavatories in restrooms of public facilities shall be equipped with controls to limit the outlet temperature to 11 o degrees F. D § 113(b)3C Lavatories in restrooms of public facilities shall be equipped with one of the following: Outlet devices that-limit the flow of hot water to a maximum of 0.5 gallons per minute. Foot ~ctuated control valves, and outlet devices that limit the flow of hot water to a maximum of 0.75 gallons per minute. Proximity sensor actuated control valves, and outlet devices that limit the flow of hot water to-a maximum of 0.75 gallons per 111inute. Self-closing valves, and outlet devices that limit the flow-of hot water to a maximum of 2.5 gallons per minute, and 0.25 gallons/cycle (circulating system). Self-closing valves, and outlet devices that-limit the flow of hot water to a maximum of 2.5 gallons per minute, and 0.50 gallons/cycle (non-circulating system). Self-closing valves, and outlet devices tftat'limit the flow of-hot water to a maximum of 2.5 gallons per minute, and 0.75 gallons/cycle (foot switches and.proximity sensor controls). Energypro 3.1 By EnergySoft User Number_: 5151 Job Number: 2147 Page:21 of 21 ISIS/IBIS Pharmaceuticals 1891 Rutherford DATE: 11 13 1 TIME: 7 6 AM Isisibis ALL INFORMATION PRESENTED IS FOR REVIEW, APPROVAL INTERPRETATION AND APPLICATION BY A REGISTERED ENGINEER ONLY BUSSPOWER THREE PHASE FAULT ANALYSIS PROGRAM VERSION 1.0 COPYRIGHT SKM SYSTEMS ANALYSIS, INC. 1983, 1986 DISTRIBUTED EXCLUSIVELY BY BUSSMANN, COOPER INDUSTRIES lDATE:11 13 1 TIME: 7 6 AM PAGE 2 ISIS/IBIS Pha~maceuticals 1891 Rutherford C O N T R I B U T I O N DAT A ================================================================== CONTRIBUTION GEN/MOTORS FROM NAME NO NAME P/KVA Xd" VOLTAGE L-L SYMMETRICAL DUTY KVA AMPS X/R H ================================================================== ========== ·= CHILLER 1 CH-1 75. . 20 POS SEQUENCE IMPEDANCE 667 PER UNIT AH-1 24 AH-1 50. . 20 480. .00000 + J 2.66 480. Page 1 C/Jot 33/J POS SEQUENCE IMPEDANCE 000 PER UNIT SDGE 998 SDGE POS SEQUENCE IMPEDANCE 007 PER UNIT lDATE: 1:1 13 1 TIME: 7 6 AM PAGE 3 ISIS/IBIS Pharmaceuticals 1891 Rutherford Isisibis .00000 + J 4.00 480. 24942. 30000. 30.0 . 00134 + J . 04 F E E D E R DAT A ============================= .. =====·============================== ------------ FEEDER FROM FEEDER TO QTY VOLTS LENGTH FEEDER D ESCRIPTION NO NAME NO NAME /PH L-L FEET SIZE TYPE DUCT INSUL ------===--------------=--.--------------------------------------- ------------ 1 CH-1 999 MSA 1 480. 300. 500 C M THWN POS SEQ z . 0-294 + J .0466 OHMS/MFT .03828 + J .06 068 PER UNIT 2 T-LP4B-P 6 DBl 1 480. 10. 2 C M THWN POS SEQ z .2020 + J .0585 OHMS/MFT .00877 + J .00 254 PER UNIT 3 T~LP4B-S 4 LP4B 1 208. 20. 4/0 C M THWN POS SEQ z .0640 + J .0497 OHMS/MFT .02959 + J .02 298 PER UNIT 4 LP4B 5 LP4C 1 208. 5. 2 C M T-HWN POS SEQ z .2020 + j .0585 OHMS/MFT .02335 + J .00 676 PER UNIT 6 DBl 7 MlA 1 480. 20. 500 C M THWN POS SEQ Z .0294 + J .0466 OHMS/MFT .00255 + J .00 Page 2 Isisibis 405 PER UNIT 6 DBl 8 T-LP4-P 1 480. 10. 4/0 C M THWN POS SEQ z .0640 + J .0497 OHMS/MFT .00278 + J .00 216 PER UNIT 6 DBl 13 SG-1 1 480. 80. 4/0 C M THWN POS SEQ z .0640 + J .0497 OHMS/MFT .02222 + J .01 726 PER UNIT 6 DBl 14 LlA 1 480. 30. 2 C M THWN POS SEQ Z .2020 + J .0585 OHMS/MFT .02630 + J .00 762 PER UNIT 6 DBl 16 ATS-1 2 480. 15. 350 C M THWN POS SEQ z .0378 + J .0491 OHMS/MFT .00123 + J .00 160 PER UNIT 6 DBl 999 MSA 3 480. 270. 600 C M THWN POS SEQ z .0257 + J .0463 OHMS/MFT .01004 + J .01 809 PER UNIT 9 T-LP4-S 10 LP4 2 208. 10. 3/0 C M THWN POS SEQ z .0805 + J .0519 OHMS/MFT .00930 + J .00 600 PER UNIT 10 LP4 11 LP4A 1 208. 10. 4/0 C M THWN POS SEQ z .0640 + J .0497 OHMS/MFT .01479 + J .01 149 PER UNIT 16 ATS-1 17 EDB 2 480. 10. 350 C M THWN POS SEQ z .0378 + J .0491 OHMS/MFT .00082 + J .00 107 PER UNIT 17 EDB 18 ELl 1 480. 270. 500 C M THWN POS SEQ z .0294 + J .0466 OHMS/MFT .03445 + J .05 461 PER UNIT Page 3 Isisibis 17 EDB 19 T-EPlA-P 1 480. M THWN POS SEQ z .0640 + J 324 PER UNIT lDATE:11 13. 1 TIME: PAGE 4 ISIS/IBIS Pharmaceuticals 1891 Rutherford 7 .0497 OHMS/MFT 6 AM 15. 4/0 C .00417 + J .00 F E E D E R DAT A FEEDER FROM ESCRIPTION NO NAME .DUCT INSUL FEEDER TO NO NAME QTY VOLTS /PH L-L LENGTH FEET FEEDER D SIZE TYPE -----------------------.. ------------------------------------------ 17 EDB M THWN POS SEQ Z 762 PER UNIT 17 EDB M THWN POS SEQ Z 324 PER UNIT 20 T-EPlA-S M THWN POS SEQ Z 600 PER UNIT 21 EPlA M THWN POS SEQ Z 574 PER UNIT 22 EP:1.B M THWN POS SEQ Z 676 PER UNIT 24 AH-1 1 480. .2020 + J .0585 OHMS/MFT 25 EL2 1 480. .0640 + J .0497 OHMS/MFT 21 EPlA 2 208. .0805 + J .0519 OHMS/MFT 22 EPlB 1 208. .0640 + J .0497 OHMS/MFT 23 EPlC 1 208. .2020 + J .0585 OHMS/MFT Page 4 30. 2 C .02630 + J .00 15. 4/0 C .00417 + J .00 10. 3/0 C .00930 + J .00 5. 4/0 C .00740 + J .00 5 • 2 C .02335 + J .00 Isisibis 998 SDGE 999 MSA 6 480. 70. 750 C N THWN POS SEQ Z 180 PER UNIT .0194 + J .0356 OHMS/MFT .00098 + J lDATE:11 13 1 TIME: 7 6 AM PAGE 5 ISIS/IBIS Pharmaceuticals 1891 Rutherford T R A N S F O R M E R DAT A PRIMARY RECORD EC NOMINAL NO NAME LA J.CVA ------------ 2 T-LP4B-P ;ms. 75.0 POS SEQ z 464 PER UNIT 8 T-LP4-P 416. 150.0 POS SEQ z 667 PER UNIT 19 T-EPlA-P 416. 150.0 POS SEQ z 667 PER UNIT lDATE:11 13 1 PAGE 6 VOLTS CONN L-L D 480. 2.7742 + .;r D 480. 2.7740 + J D 480. 2.7700 + J TIME: 7 ISIS/IBIS Pharmaceuticals 1891 Rutherford T H R E E PRI * SECONDARY RECORD VOLTS FLA NO NAME CONN L-L 90. 3 T-LP4B-S YG 208. 4.1598 PERCENT .36990 + J 180. 9 T-LP4-S YG 208. 4.1500 PERCENT .18493 + J 180. 20 T-EPlA-S YG 208. 4.1500 PERCENT .18467 + J 6 AM P H A S E FAULT R E P O R T .00 s F .55 .27 .27 ====---====----==~ ----~===-----===--=---===---------------------- Page 5 Isisibis 1 CH-1 FAULT: 11367. RMS. SYM AMPS, 9450. KVA X /R: 2.630 VOLTAGE: 480. IMPEDANCE TO GND= .00867 + J .02279 OHMS CONTRIBUTIONS: CHILLER 451. AMPS X /R: 9999.999 999 MSA 10947. AMPS X /R: 2.518 2 T-LP4B-P FAULT: 18661. RMS SYM AMPS, 15515. KVA X /R: 2.947 VOLTAGE: 480. IMPEDANCE TO GND= .00477 + J .01406 OHMS CONTRIBUTIONS: 6 DBl 18661. AMPS X /R: 2.947 3 T-LP4B-S FAULT: 3807. RMS SYM AMPS, 1372. KVA X /R: 1.576 VOLTAGE: 208. IMPEDANCE TO GND= .01690 + J .02664 OHMS CONTRIBUTJONS: 2 T"-LP4B-P 3807. AMPS X /R: 1. 576 4 LP':lB FAULT: 3631. RMS SYM AMPS, 1308. KVA X /R: 1.520 VOLTAGE: 208. IMPEDANCE TO GND= .01818 + J .02763 OHMS CONTRIBUTIONS: 3 T-LP4B-S 3631. AMPS X /R: 1. 520 5 LP4C FAULT: 3544. RMS SYM AMPS, 1277. KVA X /R: 1.455 VOLTAGE: 208. IMPEDANCE TO GND= .01919 + J .02792 OHMS CONTRIBUTIONS: 4 LP4B 3544. AMPS X /R: 1,455 6 DBl FAULT: 20146. RMS SYM AMPS, 16749. KVA X /R: 4.897 VOLTAGE: 480. IMPEDANCE TO GND= .00275 + J .01348 OHMS CONTRIBUTIONS: 16 ATS-1 300. AMPS X /R: 146.934 999 MSA 19852. AMPS X /R: 4.825 Page 6 Isisibis 7 MlA FAULT: 18735. RMS SYM AMPS, 15576. KVA X /R: 4.314 VOLTAGE: 480. IMPEDANCE TO GND= .00334 + J .01441 OHMS CONTRIBUTIONS: 6 DBl 18735. AMPS X /R: 4.314 8 T-LP4-P FAULT: 19271. RMS SYM AMPS, 16022. KVA X /R: 4.119 VOLTAGE: 480. IMPEDANCE TO GND= .00339 + J .01397 OHMS- CONTRIBUTIONS: 6 DBl 19271. AMPS X /R: 4.119 9 T-LP4-S FAULT: 7081. RMS SYM AMPS, 2551. KVA X /R: 1. 689 VOLTAGE: 208. IMPEDANCE TO GND= .00864 + J .01459 OHMS CONTRIBUTIONS: 8 T-LP4-P 7081. AMPS X /R: 1. 690 10 LP4 FAULT: 6906. RMS SYM AMPS, 2488. KVA X /R: 1. 643 VOLTAGE.: 208. IMPEDANCE TO GND= .00904 + J .01485 OHMS CONTRIBUTIONS: 9 T-LP4-S 6906. AMPS X /R: 1. 643 11 LP4A FAULT: 6617. RMS SYM AMPS, 2384. KVA X /R: 1. 586 VOLTAGE: 208. IMPEDANCE TO GND= .00968 + J .01535 OHMS CONTRIBUTIONS: 10 LP4 6617. AMPS X /R: 1. 586 13 SG-1 FAULT: 14474. RMS SYM AMPS, 12033. KVA X /R: 2.217 VOLTAGE: 480. IMPEDANCE TO GND= .00787 + J . 01745 OHMS CONTRIBUTIONS: 6 DBl 14474. AMPS X /R: 2.217 14 LlA FAULT: 15748. RMS SYM AMPS, 13092. KVA X /R: 1.729 VOLTAGE: 480. IMPEDANCE TO GND= .00881 + J Page 7 .01523 OHMS /R: 1. 729 lDATE:11 13 1 PAGE 7 Isisibis CONTRIBUTIONS: 6 DBl TIME: 7 6 AM ISIS/IBIS Pharmaceuticals 1891 Rutherford T H R E E P H A S E FAULT 15748. AMPS X R E P O R T -----~ ----------------------------------------=----------===---==- ------------ 16 ATS-1 FAULT: 19566. RMS SYM AMPS, 16267. KVA X /R: 4.574 VOLTAGE: 480. IMPEDANCE TO GND= .00303 + J .01384 OHMS CONTRIBUTIONS: 6 DBl 19273. AMPS X /R: 4.504 17 EDB 300. AMPS X /R: 155.652 17 EDB FAULT: 19196. RMS SYM AMPS, 15959. KVA X /R: 4.389 VOLTAGE: 480. IMPEDANCE TO GND= .00321 + J .01408 OHMS CONTRIBUTIONS: 16 ATS-1 18903. AMPS X /R: 4.321 24 AH-1 300. AMPS X /R: 152.357 18 ELl FAULT: 9591. RMS SYM AMPS, 7974. KVA X /R: 2.3'92 VOLTAGE: 480. IMPEDANCE TO GND= .01114 + J . 02666 OHMS CONTRIBUTIONS: 17 EDB 9591. AMPS X /R: 2.392 19 T-EPiA-P FAULT: 18000. RMS SYM AMPS, 14965. KVA X /R: 3.557 VOLTAGE: 480. IMPEDANCE TO GND= .00417 + J .01482 OHMS CONTRIBUTIONS: 17 EDB 18000. AMPS X /R: 3.557 Page 8 Isisibis 20 T-EPlA-'S FAULT: 6997. RMS SYM AMPS, 2521. KVA X /R: 1. 682 VOLTAGE: 208. IMPEDANCE TO GND= .00877 + J .01475 OHMS CONTRIBUTIONS: 19 T-EPlA-P 6997. AMPS X /R: 1. 682 21 EPlA FAULT: 6826. RMS SYM AMPS, 2459. KVA X /R: 1. 636 VOLTAGE: 208. IMPEDANCE TO GND= .00917 + J .01501 OHMS CONTRIBUTIONS: 20 T-EPlA-S 6826. AMPS X /R: 1. 636 22 EPlB FAULT: 6682. RMS SYM AMPS, 2407. KVA X /R: 1. 607 VOLTAGE: 208. IMPEDANCE TO GND= .00949 + J .01526 OHMS CONTRIBUTIONS: 21 EPlA 6682. AMPS X /R: 1. 607 23 EPlC FAULT: 6399. RMS SYM AMPS, 2305. KVA X /R: 1.481 VOLTAGE: 208. IMPEDANCE TO GND= .01050 + J .01555 OHMS CONTRIBUTIONS: 22 EPlB 6399. AMPS X /R: 1.481 24 AH-1 FAULT: 15182. RMS SYM AMPS, 12622. KVA X /R: 1. 752 VOLTAGE: 480. IMPEDANCE TO GND= .00905 + J .01585 OHMS CONTRIBUTIONS: AH-1 301. AMPS X /R: 9999.999 17 EDB 14922. AMPS X /R: 1. 712 25 EL2 FAULT: 18000. RMS SYM AMPS, 14965. KVA X /R: 3.557 VOLTAGE: 480. IMPEDANCE TO GND= .00417 + J .01482 OHMS CONTRIBUTIONS: 17 EDB 18000. AMPS X /R: 3.557 998 SDGE FAULT: 30739. RMS SYM AMPS, 25556. KVA X /R: 30.452 Page 9 Isisibis VOLTAGE: 480. IMPEDANCE TO GND= .00030 + J 30000. AMPS 739. AMPS .00901 OHMS /R: 30.000 /R: 78.445 999 MSA /R: 18. 4.26 .00941 OHMS /R: 71.239 /R: 108.204 /R: 18. 064 lDATE:11 13 1 PAGE 8 CONTRIBUTIONS: FAULT: 29419. VOLTAGE: 480. CONTRIBUT:I:ONS: TIME: 7 6 AM ISIS/IBIS Pharmaceuticals 1891 Rutherford FA U L T S T U D y BUS RECORD VOLTAGE NO NAME L-L 1 CH-1 480. 2 T-LP4B-P 480. 3 T--LP4B-S 208. 4 LP4B 208. 5 LP4C 208. 6 DBl 480. 7 MlA 480. 8 T-LP4-P 480. 9 T-LP4-S 208. 10 LP4 208. 11 LP4A 208. 13 SG-1 480. 14 LlA 480. 16 ATS-1 4-80. 17 EDB 480. SDGE 999 MSA RMS SYM AMPS, 24459. KVA IMPEDANCE TO_GND= .00051 + 1 CH-1 441. AMPS 6 DBl 298. AMPS 998 SDGE 28681. AMPS s UM MARY AVAILABLE RMS DUTIES 3 PHASE MOMENTARY 11367. 12365. 18661. 20756. 3807. 3877. 3631. 3689. 3544. 3591. 20146. 25117. 18735. 22685. 19271. 23086. 7081. 7251. 6906. 7056. 6617. 6742. 14474. 15301. 15748. 16158. 19566. 24014. 19196. 23336. Page 10 J X X X X X X • Isisibis . ~ 18 ELl 480. 9591. 10261. 19 T-EPlA-P 480. 18000. 20851. 20 T-EPlA-S 208. 6997. 7162. 21 EPlA 208. 6826. 6971. 22 EPlB 208. 6682. 6814. 23 EPl·C 208. 6399. 6490. 24 AH-1 480. 15182. 15597. 25 EL2 480. 18000. 20851. 998 SDGE 480. 30739. 49822. 999 MSA 480. 29419. 45786. 25 BUSES, 27 BRANCHES, 3 CONTRIBUTIONS *** SHORT CIRCUIT STUDY COMPLETE*** Page 11 12/19/01 WED 16:13 FAX 760 598 6801 GOOD & ROBERTS Sent By: MPE CONSULTING,INC.; . 858 578 4761; Dec-19-01 5:20PM; 12/ 19/01 WED U: 12 FAX 760 ·598 6801 GOOD & ROBERTS DEC-1~-2001 WED _09:37 AM OITY OF OARSLBAD FAK NO, 760 60'2 8558 A11t1: t<Atf~ Plumhin, .. Electr/. Pl'oject Address r ·,erlliit"/fJa •.... .--;..a..c~.......&..>-, Qul;!St/ons below refer ro work being done ior this p~rmlr only. ' •-Numb~r of l'lSW or relocated f.lxtul't!s, tfi!P.&, orfloo -drains? • New bi.tllcfing sewer line? • Number of roof drains1 • lnst1ll/aJter water tinel • N~mber of Wi!ter hetitersf ,. • Nurn!J«!r of: hpsc bib$? ,, Yes Yes X X • Ou piping sy.stem • Install X _ ~epair . • Number of new or ref ocated gas outlets + New water meter- EJe~L • N4mber of new panels or subpanelsl .· .. : .... No .. of._, P srza . Pot.abfe -......... --Irrigation Sl"'t;: or New Service @002 Page 1 ~DOI P. 02 .4~:t Ne, ¢ Nu -2- I • Single Phase , Number of amperes Lt/& • Three Phase • Three, Ph21se -480 Mecb;ioir;al • Number o( .exhaust fansl • Number of exhau$l hoodsr • Number of boiler$ or compressors? ,. • New or relocated dua warkr , .. N~mber of amperes ___ _ Number of amperes ___ _ Yes ,C:: No __ Number of HPl • ~--1 12,.· Yes X Na __ 8Ef0RE Tt-tE PfRMIT CAN BE FEE'D OUT Tl iJS FORM N'EDS TO BE RfTURNED TO THE BUILDING DEPARTMENT .. F NUMBErt (760) 602•8;558 AIR POI.LIITION CONTRII. DISffllCT COUNTY OF SAN DIEGO February 21, 2002 --• •-a:.,_ .. _, __ ~--1.. ~--~ ... -~-- GOOD AND ROBERTS' 2320 COSTEAU CT VISTA CA 92083 Air Pollution Control Board Greg Cox Dianne Jacob Pam Slater Ron Roberts Bill Horn District 1 District 2 District 3 District 4 District 5 Air Pollution Control District R. ]. Sommerville Direcror After examination of your Application No. 977399 for an Air Pollution Control District (District) Authority to Construct and Pennino Operate for art emergency engine/generator located at 1891 Rutherford Rd., Carlsbad, CA, 92908, the District has decided on the following action: Authority to Construct is granted pursuant to Rule 10, 20, 21 and 1200 of the Air Pollution Control District Rules and Regulations for: Emergency standby engine, Detroit Diesel Spectrum MTU Model 400DSE; EPA certified number DDX-NR8-01-06,-S/N to be determined, BHP rating 635 BHP, equipped with a turbocharger, driving a 405 KW generator. The engine listed above shall be referred to herein as the-"engine". This Authority to Construct is granted with the following conditions: 1. Permittee shall provide access, facilities, utilities and any necessary safety equipment, with the exception of personal protective equipment requiring individual fitting and specialized training, for source testing and inspection upon request of the District. 2. The emissions of oxide~ of nitrogen (NOx) in parts per million by volume (ppmv), calculated as nitrogen dioxide at 15% oxygen on a dry basis shall not exceed 6.9 g/bhp-hr or 535 ppmv. (Rule 69.4.l(d.1)) 3. The emissions of carbon monoxide (CO) calculated at 15% oxygen on a dry basis, shall not exceed 4,500 ppmv. (Rule 69.4.l(d.2)) 4. The engine shall use only California Diesel Fuel. (Rule 69.4.l(d.4)) · 5. Air contaminant emissions from engine exhaust and engine crankcase vent shaJI not be more dense than 20% (or Number 1 on Ringle:inann Chart) for more than three (3) minutes in any consecutive 60 minute period. (Rule 50) 6. The equipment described above shall not cause or contribute to public nuisance. (Rule 51) 9150 Chesapeake Drive• San Diego• California 92123-1096 • (858) 650-4700 FAX (858) 650-4659 • Smoking Vehicle Hotline l-800-28-SMOKE $ Printed on Recycled Paper ISIS Pharmaceuticals Application No. 977399 February 21, 2002 -2- 7. The engine operation shall not exceed 52 hours per calendar year for non-emergency purposes (testing and maintenance), and 200 hours per year for total use. (Rule 69 .4.1 (b.3.i} and Rule 1200) 8. The engine shall be equipped with either a non-resettable totalizing fuel meter or a non- resettable elapsed operating hour meter. (Rule 69.4.l(e.3)) 9. The engine shall be constructed to accommodate installation of catalyzed diesel particulate filters in the future. 10. The owner or operator shall conduct periodic maintenance of this engine and add-on control equipment as recommended by the engine and control equipment manufacturers or as specified by any other maintenance procedure approved in advance, in writing, by the District. The periodic maintenance shall be conducted at least once each calendar year. (Rule · 69.4.l(f.2)) 11. The owner or operator of the engine shall keep the following records: California Diesel Fuel certification, manual of recommended maintenance provided by the manufacturer, or other maintenance procedures as approved in writing, in advance, by the District. These records shall be kept on site for at least the same period of time, as the engine to which the records apply is located at the site. (Rule 69.4.l(g.l)) 12. The owner or operator of this engine shall maintain an operating log containing, at a minimum, the following: dates and times of engine operation, indicating whether the operation was for non-emergency purposes or during an emergency situation and the nature of the emergency, if available (these records are not required if the total engine operations for any purpose, including emergency situation, do not exceed 52 hours in a calendar year); total cumulative hours of operation per calendar year, based on actual readings of engine hour or fuel meter; records of periodic maintenance including dates maintenance was performed. (Rule 69.4.l(g.2)) · 13. All records shall be kept on site for at least three (3) years, unless otherwise indicated by the conditions~of this permit,.andmade..a:vai.lableto-the District upon request. (Rule 69.4. l(g.6)) 14. Initial or periodic source test is not required until an appropriate test method is approved by the District and ARB, provided that the engine and control system are maintained in accordance with the conditions of this permit, and there is no evidence of engine tampering. (Rule 69.4.l(i.4)) 15. This Authority to Construct authorizes temporary operation of the above-specified engine. This temporary Permit to Operate shall take effect upon written notification to the District that construction has been completed in accordance with this Authority to Construct. This temporary Permit to Operate will remain in effect, unless withdrawn or modified by the District, until a revised temporary permit (Startup Authorization) is issued or a Permit to Operate is granted or denied. ~,· i.. ~ ISIS Pharmaceuticals Application No. 977399 -3- February 21, 2002 16. Upon completion of construction in accordance with this Authority to Construct and prior to commencing operation, the permittee must complete and mail, deliver or fax the enclosed Construction Completion Notice to the District. After mailing, delivering or faxing the notice, the permittee may commence operation of the engine. Operation must be in compliance with all of the conditions of the Authority to Construct and Applicable District rules. 17. This Authority to Construct shall be posted on or within 25 feet of the engines or maintained readily available at all times on the operating premises. This Air Pollution Control District Authority to Construct does not relieve the holder from obtaining permits or authorizations, which may be required by other governmental agencies. Within 30 days· after receipt of this Authority to Construct, the permittee may petition the Hearing Board for a hearing on any conditions imposed herein in accordance with Rule 25. This Authority to Construct is not transferable· and will expire on February 21, 2003, unless an extension is requested in writing. 'If you have any questions regarding this action, please contact the undersigned at (858) 650-4606 . .ir Pollution Control Engineer JFT:el enclosure I.D.#15 0847A CONSTRUCTION COMPLETION NOTICE San Diego County Air Pollution Control District 9150 Chesapeake Drive San Diego, CA 92123-1096 (858) 650-4700 FAX: (858) 650-4659 Please complete the "APPLICANT USE ONLY" portion of this notice and fax or mail it to the APCD. The following information has been included based on your application information. Please note any corrections to this information. COMPANY NAME (DBA): GOOD AND ROBERTS APPLICATION#: -~9~7~73=9~9- EQUIPMENT ADDRESS: 1891 RUTHERFORD RD. CARLSBAD CA TYPE OF EQUIPMENT: EMERGENCY ENGINE/GENERATOR APCD PROJECT ENGINEER: ---------=-JO=-R=G=E=-=T=AL==-=A:..;.VE=RA=-=· =-------TELEPHONE: (858) 650-4606 APPLICANT USE ONLY DATE CONSTRUCTION WAS COMPLETED: ______________________ _ PERSON PROVIDING NOTIFICATION (Please Print): _____________________ _ SIGNATURE: ----------------------------------- DATE OF NOTIFICATION: ____________ TELEPHONE: ____________ _ , APCDUSE I.D.#:15 0847A VAX ENTRY DATE: DATE RECEIVED: ' I Sent By: MPE CONSULTING,INC.; 858 578 4761; Dec-20-0~ 10:21AM; Page 2 SAN DIEGO AIR POLLUTION CONTROL DISTRICT Sl.fP.PJ:,EiVIENTAL APPLICATION INFORMATION San Diego APCD Use Only 1 2 FEE SCHEDULE 34 A-E, G Appl. No.: ID No.: INTERNAL COMBUSTION ENGINES (Please type or print the information requested below.) 3 Company Name: . l ~l "';:::> '.t:?bAiw1 , 4 Equipment Address:.___._I ...... B ..... 4 ..... -\ _ _.....~....,,,:\._,;.¼._._ ...... -;!,...F<__,fu.,c.' ,_/ ..-cL=.-.._e .... cL.-......, __,CA,r~L.:,'--~-h=6....,,d_<"---',C~A:.__'t_._?.JX)=-..;;;._,:8'=--- l 5 6 A. EOU.IPl\-lENT DESCRlPTJiON ~ ~ Engine Mfr.: t& it ~ES'4 /fJ~tfilJ3.-JM9del: _l/c)_p'-'fj __ S ____ e[' ___ ~,---SIN:_~-_ ~ Engine hp Rating: I,:, s;:-: Fuel Type: ~ diesel* D natural gas D gasoline 7 8 Combination of fuels (spec~fy) ---------"-------------------- 9 10 11 12 13 Engine Equipment: @ turbocharger , 0 aftercooler D 4-degree retard of fuel injection 0 exhaust ga~ recirculation D lean burn D pre-chamber combustion O air/fuel controller ig: crankcas~ (blow-by) emission control equipment -(specify) eM,o2. Cla;,cJ, -~ itJ-Model a:v~ bJl;[ 14 15 Describe any in stl(l.ck emission control ~d/or monitoring devices. (i.e., catalytic converter) 16 17 * Diesel fuel must be Certified California Diesel. 18 19 B. PROCESSDESCRIPTION 20 · Engine Drives: 21 D cmnpressor. ____ cfin ¥1generator ._ l/Q S--kw D pump _____ gmp D other (specify) _______ _ 22 Equipment is: D portable E,l stationary 0 continuous service 23 0 p~·ak shaving electrical supply D cogeneration 24 D emergency electrical supply D used at any time 25 26 C. OPERATING SCHEDULE (typical) Hours/day Days/week Weeks/year Avera-ge :3o M'-JJ _ 1~1"'- Maximum 27 JF0-5/01 1 of 2 OVER Sent By: MPE CONSULTING,INC.; 858 578 4761; Dec-20-01 10:21AM; Page 3/3 28 29 30 31 32 33 · ., . D. FUEL CONSUMPTION AND EMISSIONS (@100% Load) . Liquid Fuel:· 2t,2-2 gal/hr __ ___,_ gal/wk Gaseous Fuel: LIVHR /HR 12% CO2 ~gal/yr --t-gal/yr ______ /yr PPM 34 Exhaust Temperature tf 7 3 °F 35 Fuel Supplier: __ 5<-=o ___ Vl_'t:.«..12 _____ t::,__.(_,..,L.:C.---UJ"--=-"U--=-F-'p.#I.-,!'--"-. --,f_-__ a"-z_-?A:f~-+--'o'-=----,J""--" _______ _ 36 Fuel Sulfur Content: ___.._._,,;--"----___ %Sulfur(% wt. as S. (Liquid Fuel)) 37 Fuel Sulfur Content:· % Sulfur(% vol. as H2S (Gaseous Fuel)) 38 39 40 41 Engine year of manufacture: P, -2. Cc I 'SCA-~~ -i . n\l €A.RS Certification No.: . 2S kl"..> EPACertificationNo.: Db't.-Jtt,-E>l-o~ 2 E. ADDITiONALINFORMATI.ON 44 45 46 47 -48 49 50 51 52 5.3 54 55 Supply a copy of the manufacturer's brochure. Name of.Preparer: ~l>....,t:3.~vf--_,,,,,_&__..._.· '""".b"""n'-"~----"·------Title: E-\.ec.ancJ i-11.~~ Date: _\.LJ2'-_...==-+--/'-2-.o._,/'--'1'--'o0='--'-' __ NOTE TO APPLJCANT: Before acting on an application for Authority to Constmct, Permit to Operate, or Permit lo Sell or Rent, the Distiict · may require fi11th,er information, plans, or specifications .. Forms with insufficient infmmation may be rt:tumed to the applicant for completion, which will cause a delay in application processing and may increase processing fees. The applicant should correspond with equjpment und material mauuf~clurefs to obtain the infom1ation requested on this supplemental form. 2 of 2 (34A-E, G) SAN Dl'EGO REGl'ONAL 1-f/J . . l ··~o Management Division HAZARDOUS MATERIALS QUESTIONNAIRE It 7;95'RO c111·n ., u1 11110 Business Name Telephone IS.L~ vV\v-11\A. · _contact J. C _ Lew'\..::::> ~ bS"b -::J-{2. b-(OD Mailing Address City State Zip Plan File# ~\...ll.-(L-{ f-tA.h'\ V\W\I'\ t:)r-W-500 S..a/l D,~ CA-""\L_l~~ c~o( ~~,s S1t!,I Address City .State Zip Plan File# · . l'M{ ,~&d U_.·,Cctt~d ~ 1 'l..f:.c:Jo· , . . PART I: FIRE DEPARTMENT· HAZARDOUS MATERIALS MANAGEMENT DIVISION: OCCUPANCY CLASSIFICATION .. - Indicate by circling the item, whether your bu111ne1s will use, proceH, or store any of the following ,hazardous materials. If any ot the items are circled, applicant must contact the Fire Protection Agency with jurildiction prior to plan submittal. PAUi. 10241 1. Explosive or Blastlng Agent• •. Flammable Solids 7. Pyrophorics 10. Sryogenics CHK 2, Compressed Gases 5. Organic Peroxides 8. Unstable Reactive• 11; Highly Toxic or Toxic Materials 13. Corrosives $345. 00 1 4., Other Health Hazards 3. Flammable_or Combustible Uquida 8.-Oxidizers 9. Water ReactivH 12. Radioactive• · PART II: COUNTY Of SAN OiEGO HEALTH DEPARTMENT. HAZARDOUS MATERIALS MANAGEMENT OIVISION: . CONTINGENCY PLAN REVIEW; . . -. · If the answer to any of the questions is yH, applicant must contact th• County of San Diego Hazardous Materials Menegement Division, 1255 Imperial Avenue, 3rd Floor, San Diego, CA 92-188-5261. Telephone (819) 338·2222 prior to the itsuance of a building permit. FEES MAY .BE REQUIRE[) Yes No . 1 .D -.I• your businaH listed on the reverse •Id• of this form7 . 2. D Will your busineH dispoH of Hazardoua Substance• or Medica,I Wast, in any amount7 3·. c:::J Will your busineH store or handle Hazardoua Substances in quantities ·equal to or greater than 55 gallona, 500· pounds, 200 cubic feet or carcinogens/reproductive toxina in any quantity? 4, CJ Will your bU!linHI UH an exitting Or inatall an underground storage tank7 s.·CJ Will your businH• atore or handle Acutely Hazardous Materials?- OFFIC~ USE ONLY D RMPP Exempt Date Initials 0 · RMPP Required Date Initials 0 RMPP Completed Date Initials PART Ill: SAN DIEGO COUNTY AIR POIJ.UTIQN CONTROL DISTRICT . . - If the answer to any of the question• ii yea, applicant muat contact the Air Pollution C~nttol District, 9150 Chesapeake Drive, San Diego, CA 92123. Telephone (619)· ~94-3307 prior to the iHuance of a building permit. YES NO . 1. CJ ~Will the intended occupant inatall or UH any of the equipment listed on the Listing of Air Pollution Control District Permit Categories, on the -rnerss sida of thi• form? . 2. CJ CJ (ANSWER ONLY IF QUESTION 1 IS Y!:S.) Wil! the •ubi•cJ facility be located within 1,000 feet of the outer boundary of a school (K through 1 21 .. listed in the current Directory of School a~ Community College Districts, published by the San Diego County Office of Education and the current California Private School Directory, compiled in accordance with provisions of Education Code Section 331907 Briefly de~cr1be nature ~f the intended 6us1neaa aotivtty: Name of Owner or Authorized Agent: · · under penalty of pe~ry thit to the best of my knowl1dge and belief the resp·onsH med1 herein are true Date: lo It,,,(_, IO \ Do not write below this line FIRE DEPARTMENT OCCUPANCY CLASSIFICATION: ...... _______ ....., _____________________ _ BY:_..,_ __________ ..,... ________ _. ______________ __. __ Cata:, _____________________ _ EXEMPT l'IIOM l"EIIMIT IIECUIIIIMDITI . COUNTY·HMMD Envir011111enlal Hcaldl Sc!Vicct DHS:HM-9171 (6/92) APCD Al'PftOVED fall OCCUtANCY COUNTY·HMMD APCb ,-., .... APCD it6 (Rev. 'f0/97) SAN DIEGO AIR POLLUTION CONTROL DISTRICT 9150 CHESAPEAKE DRIVE, SA:N DIEGO CA 92123-1096 PHONE (858) 650-4700 • FAX (858) 650-4659 , ' PERMIT/ REGISTRATION APPLICATION FILING THIS APPLICATi:O~ DOES NOT GRANT PERMISSION ro C_QNSTRUCT OR TO OPERA TE EQUIPMENT IMPORTANT REMINDERS: Read instructions on the reverse _side of this form pri'or to completing this application. Please ensure that all of the following are i!)cJuded before you submit the application: 12}.Appropriate Permit Fee fil<Gompleted Supplemental Form(s) SSignature on Application REASON FOR SUBMITTAL OF APPLICATION: (check the appropriate item and enter Application (AP) or Permit to Operate (PO) number if required) I. di'l'ew Installation Equ~t 2. D Existing Unpermitted Equipment-or·Rule 11 Change 3. D Modification of Existing Permitted 4. D Amendment to Existing Authority to Construct or AP 5. D Change of-Equipment Location 6. D Change of Equipment Ownership 9. D Banking Emissions 7. D Change of Pe;rmit Conditions 8. D Change Permit to Operate Status to Inactive 10. D Registration of Portable Equipment I I. D Other (Specify) __________________ _ 12. List.affected AP/PO#(s): --~---- APPLICANT INFORMATION 13. Name ofBusiness(DBA) IS.I::::,. PhCJ"wJat ceuh c.c,.1 '>-, 14. Nature ofBusiness g_ 1 ,_D IG..bor-"'.,:to (1~ 15. Does this organization own or operate any other APCD pennitted.equipment at.this or any other adjacent locations in San Diego County? OYes ONo If yes, ·list assigned location !D's listed on your PO's_~-~------~--~-----------------~- 16. Type of Ownership ~ Corporation D Partnership . D Individual Owner D Government Agency D Other __________ _ 17. Name of Legal Owner (if different from D$A).'--~-----------'------------'-------------- 18. 19. 20. 21. 22. Name Mailing Address City State Phone 23. Name 24. Mailing Address 25. City 26. 27. State Phone A. Equipment Owner !to""' Cbor~ il IS..1!> _ ___,,Cfa:--=-'----~-·Zip. 0 2(D 1(' (1{,o q~ I erz.co FAX <!}toQ (on> 02.cos:- c. Permit to Operate (if different from A) ---~--------Zip _______ _ ~-~ ______ FAX~-'--~'--~--- B. Authority to Construct (if different from A) G:,ood. '\ tZvb:2 r~ \l 1 ":>:+~ -----'CA-:....,_-'------~·Zip g ?ct 3:. ( ?£o0 SZi 8 3:u, I Y FAX (3iso SZ:i ~ 1(0'.S'j D. Billing Information (if different from A) _ ___________ Zip ______ _ ~-~-------FAX~-~------ EQUIPMENT/PROCESS INFORMATION: Check Type ofEquipmeqt: ~ationary D Portable-Will operation exceed 180 days: D Yes 28. Equipment Location Address J 64 ( f."'-J11uW<i ':.cl City (41'./~d_ Parcel No. Z.I 2-I ~:O 29. State CA Zip g 2,. 0() ~ Phone '----'--------FAX'-----'---------- 30. Site Contact e<?('") G or de.A, Title '.rAC.. \ \ 1 h (0 iN1 SI\C-,L$ 8/: Phone '8<eOJ :'.j ,> ( CJ ZoD . . r 31. General Description ofEquLment/Process . ie.-"'\ f:::::, t::Jb a.r~±n r,-tL:::::. 32. ApplicationSubl)1itted by D Owner D Operator D Contractor D Consultant Affiliation. OV:-uk, kc.A== -...--;~-":--.s application is true and correct. -~:::::::::;..;,::::::._=---=--___:_-=---------:-~~~----·Date { ,e__ /,z D /zce, f Print Name -~~~~-~-~==c...=, _ ___,,.L=-=ea...i..v....,·=· _,,_l_~~--Title _>,,,,&C-'·'-"-"'c.-4..~-'--'''---"' ..... :et=i..'-'-"--'d,=--------34. 35. Company ( I"'\ C.... , Phone (~~ 3-\ 1 APCD USE ONLY AP# g~~ ID # ___ ~ __ Cust. No. -----~~_Sector: ___ UTM"s X-~--y , SIC ___ _ Receipt# __________ _ Date~-----~ AmtRec'd$~-------Fee Code ________ _ .Engineering Contact ___________ ~---Fee Code____ AP Fee$ _____ _ T&M Renewal Fee$ ____ _ Refund Claim # Date Amt$ 10/00 -jfo ,. 05-14-2002 i. I ' :/ City of Carlsbad . 1635 Faraday Av Carlsbad, CA 92008 Plan Check Revision Permit No: PCR02053 ,, Building Inspection Request Line (760) 602-2725 :Job A<;ldress: Permit Type: 1891 RUTHERFORD RD CBAD PCR Status: ISSUED 02/15/2002 JM 05/14/2002 05/14/2002 Parcel No: . Valuation: Reference #: , 2121203600 . $0.00 CB013313 Lot#: 0 Applied: Construction Type: NEW Entered By: Plan Approved: Issued: Project Title: ISIS -RACK, STRUCT,ELECTRICAL Inspect Area: ·Applicant: . BLEVINS LEOFORD 19444 FARNHAM STREET -SAN DIEGO CA 92123 ·858-712-8372 I ' /r--~-- Total Fees: $480.00 Plan Check Revision Fee Additional Fees Inspector: 7084 05/14/02 0002 0:1. Owner: DIVERSIFIED CARLSBAD 47&48 L L C 433CH.A JOLLA VILLAGE DR #110 SAN DIEGO CA 92122 Total Payments To Date: $0.00 Balance Due: $480.00 $0.00 CGF• $480.00 FINAL APPROVAL Date: ---------Clearance: ------ NOTICE: Ple~se take NOTICE that approval of your project includes the "Imposition" of fees, dedications, reservations, or other exactions hereafter collectively referred to as "fees/exactions." You have 90 d~ys from the date this permit was issued to protest imposition of these fees/exactions. If you protest them, you must follow the protest procedures set forth in Government Code Section 66020(a), an\! file the protest and any other required information with the City Manager for . processing in accordance with Carlsbad Municipal Code Section 3.32.030. Failure to timely follow that procedure will bar any subsequent legal action to attack, review, set aside, void, or annul their imposition. 02 480-00 1· FOR OFFICE USE ONLY PERMIT APPLICATION PLAN CHECK No./?{(Qt,_,53 CITY OF CARLSBAD BUILDING DEPARTMENT 1635 Faraday Ave., Carlsb~d. CA 92008 :EST. VAL. _________ _ c/56 /33!3 Validated BY-.-,_..:.,,;a,....~::,i--;,';-::::,:,-r-:-:--,-- Pate. ____ ....... _ __.r,q..-1-,,J.4-4::,,"""':;,.__ Address ¾clJo!dj. Bldg/Suite#) ~/\ Business Name (at this address) /Z:?~ BIA 17¼,((.,v,vv Legal Description Lot No. Subdivision 'Name/Number Unit No. Phase No. T cital # of uriits Assessor's Parcel # ·Existing._Use Name Address City State/Zip Telephone# ~i.i~lj'o~!!l:fEPWN~!:1J;-S2.,· Name Address City State/Zip Telephone# t§'f;!~f,1,W~~fimfdP~~iX:JiftM,t~fl~~-~:z}7:?Z~~:;;~~t:t~~(1~~~fr:~2&~~~lI1~~:J~;J:z~~~-TfS£¼:,E~~:~1;~ (Sec. 7031.5 Bvsiness and Professions Code: Any City or County which requires a permit to construct, alter, improve, demolish or repair any structure, prior to its issuance, aiso requires the applicant for ·such permit to file a signed statement that he is licensed pursuant to .the provisions of the Contractor's License Law [Chapter 9, commending with Section 10·00· of Division 3 of the Business and Professions Code] or that he is exempt therefrom, and the basis for the alleged exemption. Any violation of Section 7031.5-by any applicant for.a permit subjects the.applicant to a civil penalty of not more than five hundred dollars [$500]). Name Address City State/Zip Telephone# State License,# _________ _ License Class~· ________ _ City Business License # --"------ Designer Name Address City State/Zip Telephone State License# _________ _ ~~t~;E1VlQRKJ:J\if.~(;lWpjijS-~r1PN~~z2-~-::1~::\:1:JE1l:CT~I::~~~~~i~~~~::r~~~~-:s~D:t.;~~1JJJ-h'3~~;~~I~:~~~·-~t?Jri~'~;:if~~~:[[.~~T:~~;?~~~~~-~~~~~j Workers' Compensation ,Declaration: I hereby affirm under penalty of perjury one of the· following declarations: O I have ahd w(II maintain a certificate of consent to self-insure for workers' compensation as provided by Section 3700 of the Labor Code, for the performance of the work for whic!l this permit is issued. O I have and will maintain workers' compensation, as required by S11ction 3700 of the Labor Code, for the performance ·of the work for which this permit is issued. My worker's compensation insurance carrier·and policy. number are: ·Insurance Company ____________________ ,,,_c.. Policy No.____________ Expiration Date _______ _ .(THIS SECTION NEED NOT BE COMPLETED IF THE PERMIT IS FOR ONE HUNDRED DOLLARS [$100] OR LESS) CJ CERTIFICATE OF EXEMPTION: I certify that in the performance of the work for which this permit is issued, I shall not employ any person in any manner so as to become subject to the Workers' Compensation-Laws of California. WARNING: Failure to secure workers' compensation coverage is unlawful, and shall subject an employer to criminal penalties and civil fines up to one hundred thousand·dollars ($100,000), in addition to the cc;,st of compensation, damages as provided for in Section 3706 of the Labor code, interest and attorney's fees. SIGNATURE ____ ,,__----"",---,,---''-------,,----,,--:'--'----,------'----DATE _________ _ ~iJ~&W~,.t~~JI_U)iQt}t'DJP~l~fiiJ_j_f;~;,-.. ::-JtiX~L~}.;~;'{~ik\f{if;i;:~~~t1f:~-~-/g~~~~~t:~"-~~:_~~J~.{{?;1:~.;{f~!~~:~l'l::~l~f-:~~~;1~1~" :~t~~~~hf:\ij~':{~/t57~1t ~~i~tir:~::+;--,~-r;;~-~1 !·hereby affirm that I am exempt from the·Contractor's License Law for the following reason: 0 I, as owner of the property or my employees with wages as their sole compensation, will do the work and the structure is not intended or offered for sale (Sec. 7044, Business and Professions Code: The Contractor's License Law does not apply to an owner of property who builds or improves thereon, and who does such work himself ·or through his own employees, provided that such·improvements are not intended or offered for sale. If, however, the building or improvement is· sold within one year of completion, t_he,owner-builder will have the burden of proving that he did not build or improve for the purpose of sale). 0 I, as-owner of the property, am exclusively contracting with licensed contractors to construct the project (Sec. 7044, Business and Professions Code: The Contractor's License Law does not apply to an owner of property wlio builds or improves thereon, and contracts for such projects with contractor(s) licensed pursuant to·the Contractor's License Law). D I am exempt under Section ______ Business and,Professions Code for this reason: 1. I personally·plan to-provide the major labor and materials for construction of the proposed property improvement. D YES ONO 2. I· (have / have not) signed an applicl!tion for a building permit·for 1he proposed work. 3. I have contracted _with the following person (firm) to provide the proposed construction (include name / address / phone number / contractors license number): 4. I plan to provide portions of the work, but I have hired the following person to coordinate, supervise and provide the major work (include name / address / phone number/ contractors license number): __ .------.----,-'---------'-------'------------------------- 5. I will provide some of the work, but I have-contracted (hired) the follo~ing persons to proviae the work indicated (include name / address / phone number / type of wor~>=---------,-----------,------------------.---------~----------- PROPERTY OWNER SIGNATURE ______ __. ________ ---________ DATE_-,-______ _ 1"":0•1inwe;ffli's~ec1· 10Nfi=on;;'N'o''i.J:ifisiiiiNoo~su11£0TtJd<eiaRM'l'rmNi;;f.1'~:~1:s,:::::-:r;;,tt~:;~;:r,rt~~,r:,;1t:01:.;~~;,ts;}'::r::::1:·;·:,1' "0-·Ii.;(c,"~;~1:s~;:;:<.t:~;1.,~;,,ri:t~rQ~ ~~~!.P.,!2.~ ..... ,;;.,;:,w•'< "''"""'"''''"·' ,,,..,.,., ,.,..;;,,,";1.._," ,n-f"!!"',w,,, ,,,,,,,,""""''"',_.;,-,, ,..,,..., ,,.,.,.,"-'" ,,,_, ,.,,,.~~'""'"~-~" ....... ,,,..-.-,,..,.,.,.,., ....... ,..~~~-.A-W'l'l-l•~;J.'i;. .. ~__,.,....,"""..,~'U;.:,&6~i:;:ts1.,;.,.,.,..,,~ ..... 'T..,.~,,.,.....,,~,.,, ~~s:-.;"""''_..,,,.,.,...-llt~ ... Is the applicant or future building occupant required to submit a business plan, acutely hazardous materials registration form or risk management and prevention program under Sections 25505, 25533 or 25534 of the Presley-Tanner Hazardous Substance Account Act? D YES O NO Is the applicant or future building occupant required to obtain a.permit from the air, pollution-control district or air quality management district? 0 YES D NO Is the facility to be constructed within 1,000 feet of the outer bounda,ry of a school-site? o· YES D NO IF ANY OF THE ANSWERS ARE YES, A FINAL CERTIFICATE OF OCCUPANCY MAY.NOT BE ISSUED UNLESS THE APPLICANT HAS MET o·R IS MEETING THE REQUIREMENTS OF THE OFFICE OF EMERGENCY SERVICES AND THE AIR POLL"'TION CONTROL DISTRICT. . '-~1f~6~tlQ~~P~NPli'l~-~~~NQ:~~l~:?[2~~:ili~~Y,it1~hffif::~~~~~({~i~'~q;;~J:~~~&!~~~?;~~;~,~~:~;~~~~r~~~~~~.~};~:DJ:.·i:~~~~~~~~~1~~~1::it: I hereby affirm that there is a construction l!lnding agency for the ~ertormahce of the work for which this permit is issued (Sec. 3097(i) Civil Code). LENDER'S NAM!;, LENDER'S ADDRESS_-'----------------------- I c_ertify that I have re.ad the application and state that the above information is correct and that the information on the ·plans is accurate. I agree to comply with all City ordinances and State laws relating to building construction. I hereby authorize representatives of the Cit~ of Carlsbad to enter upon the above mentioned property for inspection purposes. I ALSO AGREE TO· SAVE, INDEMNIFY AND KEEP HARMLESS THE CITY OF CARLSBAD AGAINST ALL· LIABILITIES, JUDGMENTS, CQSTS AND EXPENSE,S WHICH MAY IN ANY WAY ACCRUE AGAiNST SAID CITY IN.CONSEQUENCE OF THE GRANTING OF THIS PERMIT. OSHA: An OSHA permit is required for excavations over 5'0w deep and demolition o.r construction of structures over 3 stories in height. EXPIRATION: Every permit issued by the building Official under the pro.visions of this Code shall expire by limitation and become null and void if the building or work authorized by such permit is not·co me ed wit ·n 180 dayi; from the date of such permit or if the building or work authorized by sucli permit is suspended or abandoned at any time after the work is com for e od o 80 days (Sedion 106.4.4 t;,niform Building Code). ; J.'r-"/ Af?PLICANT'S SIGNATURE . . DATE "']... ~ I e>?-I WHITE: File YELLOW: Applicant PINK: Finance EsGil Corporation 1.n Partnersli.ip witli. (jovemment for '.Buifaing Safety DATE: April 29, 2002 JURISDICTION: Carlsbad PLAN CHECK NO.: 01-3313 (PCR02-53) PROJECT ADDRESS: 1891 Rutherford SET:"II PROJECT NAME: Isis Pharmaceuticals Revi$ion No. 1 D P AN REVIEWER D FILE D The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's building codes. D The plans transmitted herewith will substantially comply with the jurisdiction's building codes when minor deficiencies identified below are resolved and checked by building department staff. D The plans transmitted herewith have significant deficiencies identified on the enclosed check list and should be corrected and resubmitted for a complete recheck. ~ The check list transmitted herewith is for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. D The applicant's copy of the check list is enclosed for the jurisdiction to forward to the applicant contact person. i:gj The applicant's copy of the check list has been sent to: Lt:.A?olt> 5LfV1rJ.S )9 LIL{ LJ r:,AR..t-J/-IA-H ;s,. 5A,J D1i::.C. _oI CA Cj2 J 2-3, D Esgil .Corporation staff did not advise the applicant that the plan check has been completed. ~ Esgil Corporation staff did advise the applicant that the plan check has been ·completed. Person-contacted: LE-Afc>LJ> ( "-'-H) Telephone#: c~sg}":1/;?. -¥372.._ Date contacted:½ )z.'1{ o :1 (by: k,) Fax #: Mail0elephone v Fax In Person ~ REMARKS: Set I was notice of suspension of plan review process dated February 28, 2002. REVISION I INCLUDES DELTA 3 AND DELTA 4 (CEILING FRAMING PLANS, ELECTRICAL AND STORAGE RACKS.· By: Abe Doliente Esgil Corporation D GA [gl MB D EJ D PC Enclosures: 4/25/02 trnsmtl.dot 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (858) 560-1468 + Fax (858) 560-1576 Carlsbad 01-3313 (PCR02-53) April 29, 2002 GENERAL PLAN CORRECTION LIST JURISDICTION: Carlsbad 53) · PROJECT ADDRESS: 1891 Rutherford DATE PLAN RECEIVED BY ESGIL CORPORATION: 4/25/02 REVIEWED BY: Abe Doliente FOREWORD (PLEASE READ): PLAN CHECK NO.: 01-3313 (PCR02- DATE REVIEW COMPLETED: April 29, 2002. This plan review is limited to the .technical requirements contained in the Uniform Building Code, Uniform Plumbing Code, Uniform Mechanical Code, National Electrical Code and state laws regulating energy conservation, noise attenuation and disabled access. This plan review is based on regulations enforced by the Building Department. You may have otheF corrections based on laws and ordinances enforced by the Planning Department, Engineering Department or other departments. The following items listed need clarification, modification or change. All items must be satisfied before the plans will be in conformance with the cited codes and regulations. Per Sec. 106.4.3, 1'997 Uniform Building Code, the approval of the plans does not permit the violation of any state, county or city law. • Please make all corrections on the original tracings and submit two new complete sets of prints· to: l;sgil Corp. or to the bldg. dept. of the juris. • To facilitate rechecking, please identify, ne:><:t to each item, the sheet of the plans upon which each correction on this sheet has been made and return this sheet with the revised plans. • Please indicate here If any changes have been made to the plans that are not a result of conections from this list. If there are other changes, please briefly de·scribe them and where they are located on the plans. Have changes been made not resulting from this list? D Yes D No Carlsbad 01-3313 (PCR02-53) April 29, 2002 . 1. All sh~ets of the two sets of plans shall be signed by the architect or engineer of record. Please include the stamp or seal, license. expiration date and the date the plans are signed. 2. Revised plans show that exit is passing through a warehouse. This is not allowed per section 1004.2.2 of the USG. Obtain approval from the Building Official and the Fire Chief. 3. Sheets S1 .0, S1 .1, S2.0, S2.1, S2.2, S3.1 and S3.2 of the revised plans refer to delta 4, but there are no changes on the plans shown. Please clarify. 4. Sheet 2-delta 3 of the revised structural calculation$ refers to the mechanical unit on walkable ceiling joist. It also refers to changes on sheet S2.2. I cannot seem to find these changes. Please .clarify. 5. Detail 8 on sheet S3.2 refers to partial ceiling joist framing for L 116. Clearly cross reference this detail with the ceiling framing plan on sheet S2.1. 6. The jurisdiction has contracted with Esgil Corporation located at 9320 Chesapeake Drive,-Suite 208, San Diego, California 92123; telephone number of 858/560-1468, to perform the plan review for your project. If you have any questions regardihg these plan review items, please contact Abe Doliente at .Esgil Corporation. Thank you. \ Carlsbad. 01-3313 (PCR02-53) April 29, 2002 VALUATION AND PLAN CHECK FEE JURISDICTION: Carlsbad 53) PREPARED BY: Abe Doliente BUILDING ADDRESS: 1891 Rutherford BUILDING OCCUPANCY: B/S-1 BUILDING AREA Valuation .PORTION ( Sq. Ft.) Multiplier -. Air Conditioning · Fire Sprinkler~ TOTAL VALUE Jurisdiction Code CB By Ordinance Bldg. Permit Fee by Ordinance / • I Plan Check Fee by Ordinance Type of R!3view: D Complete Review 0 Other PLAN CHECK NO.: 01-3313 (PCR02- DATE: April 29, 2002· TYPE OF CONSTRUCTION: III-N Reg. VALUE ($) Mod. $4ao.ool D Structural Only D Repetitive Fee CG Repeats 0 . Hourly 41 Hours* $384.00j * Based on hourly rate Comments: Esgil Plan Review Fee Sheet 1 of 1 macvalue.doc EsGil Corporation 1.n Partners/i.ip wit/i. (jovemment for '.Buiufing Safetg DATE: February 28, 2002 JURISDICTION: Carlsbad PLAN CHECK NO.: 01-3313 (PCR02-53) PROJECT ADDRESS: 1891 Rutherford SUBJECT: Suspension of Plan Review Process ~- SET:I ~NT CJ PLAN REVIEWER CJ FILE A plan review of the above referenced project cannot be commenced at this time, for the following reason(s): ' D The designer has requested that the plan review be delayed pendirig submittal of complete or revised plans. Please see remarks below. [SJ Esgil Corporation has determined that the plans submitted are not sufficiently complete to allow making a complete plan review. To allow the plan review to commence, the following item(s) must be addressed: D Provide a soils investigation/geologic report. D Provide structural calculations. D Provide energy calculations. D Provide legible plans. [SJ Provide complete architectural plans and details. PLEASE SEE REMARKS BELQW. D Provide complete structural plans and details. D Provide complete plumbing, mechanical and/or electrical plans. Esgil Corporation staff has made the applicant contact person aware of the need to provide the described item(s) in order to allow a complete plan review to commence. A copy of this communication will also be provided to the applicant contact person. Person contacted: Leoford Blevins \...rf'\ Date contacted: ')'/ ~(by: iS) Telephone #: 858/712-8372 Address: 19444 Farnham St., San Diego, CA 92123 [SJ REMARKS: Clearly state the scope of this building permit application. Provide a list of all the revisions . to the original set of approved plans. No architectural plans, mechanical plans or energy calculations were provided. Are the racks included also in this permit application? If so, complete plans and calculations are required for the rack system. By: Abe Doliente Esgil Corporation 2/19/02 Enclosures: . PCSuspnd.dot 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (858) 560-1468 + Fax (858) 560-1576 Es.Gil Corporation In Partnership with Government for Building Safety DATE: M:af 7, 2002 JURISDICTl.QN:. Carlsb~d PLAN CHECK: NO.: 01-3313 (PCR 02.-53) \ PROJECT ADDRESS: 1891 Rutherford SET: III PROJECT NAME: Isis Pharmaceuticals Revision No. 1 , . . - ~ANT ~ CJ PLAN REVIEWER CJ FILE D The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's building codes. ~ The plans transmitted herewith will substantially comply with the jurisdiction's building codes when minor deficiencies identified below are resolved and checked by building department staff. D The plans transmitted herewith have significant deficiencies identified on the enclosed check list and shoula be corrected and resubmitted for a complete recheck. D The check list transmitted herewith is for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. D The applicant's copy of the check list is enclosed for the jurisdiction to forward to the applicant contact person. D The applicant's copy of the check list has been sent to: (g] E;sgil Corporation staff did not advise the applicant that the plan check has been completed. D Esgil Corporation staff did advise the applicant that the plan check has been completed. Person contacted: (\ . Telephone#: \.,o""o~'-"--- Date contacted: LJ~ ) Fax #: .. 1...\,0 fo xva.,.i"'- Mail Teleph.z:-Fax In Person \"~ ~ 0 ~ ~ REMARKS: 1.Plans for the storage must be signed by the Engineer. z1Revised ~~ show that exit is passing through a warehouse. This is not allowed per section 1004.2.2 of the UBC. Obtain approval from the City Building Official and the Fire Department Chief. By: Abe Doliente Esgil Corporation D GA D MB D EJ D PC Enclosures: 5/1/02 trnsmtl.dot 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (858) 560-1468 + Fax (858) 560-1576 Carlsbad Fire Department 02053 1635 Faraday Ave. Carlsbad, CA 92008 Plan Review Requirements Category: Fire Prevention (760) 602-4660 Date of Report: _04_/_11 ____ 12_0_02 ___________ ___ Building Plan , Reviewed by: -013/½4 Name: HDR Architecture Address: 9444 Farmham St. Suite 300 City, State: San Diego CA 92123 Plan Checker: Job#: 02053 ------- Job Name: ISIS Pharmaceuticals Bldg #: PCR02053 ---------------------..,...._,---- Job Address: 1891 Rutherford Rd Ste. or Bldg. No. IZI Approved LJ Approved Subject to LJ Incomplete Review FD Job# ihe item you have submitted for review has been approved. The approval is based on plans, information and I or specifications provided in your submittal; therefore any changes to these items after this date, including field modifications, must be reviewed ,by this office to insure continued conformance with applicable codes and standards. Please review carefully all comments attached as failure to comply with instructions in this report can result in suspension of permit to construct or install improvements. The item you have submitted for review has been approved subject to the attached conditions. The approval is based on plans, information and/or specifications provided ih your submittal. Please review carefully all comments attached, as failure to comply with instructions in this report can result in suspension of permit to construct or install improvements. Please resubmit to this office the necessary plans and / or specifications required to indicate compliance with applicable codes and standards. The item you have submitted for review is incomplete. At this time, this office cannot adequately conduct a review to determine compliance with the applicable codes and/ or standards. Please review carefully all comments attached. Please resubmit the riecessary plans and / or specifications to this office for review and approval. 1st 02053- 2nd FD File# 3rd Other Agency ID C~rlsbad Fire Department 02053 1635 Faraday Ave. Carlsbad, CA 92008 Plan Review Requirements Category: Fire Prevention (760) 602-4660 Date of Report: _03 ..... 1 __ 06_12...,.0_0_2 _________ _ BuUding Plan , Reviewed by: Name: HDR Architecture Address: :9444 Farmham St. Suite 300 City, State: San Diego CA 92123 Plan Chec~er: Job#: 02053 --------- Job Name: ISIS Pharmaceuticals BI d g #: PCR02053 ------------------------ Job Address: 1891 Rutherford Rd Ste. or Bldg. No. LJ Approved LJ Approved Subject to IZI Incomplete Review FD Job# The item you have submitted for review has been approved. The approval is based on plans, information and / or specifications provided in your submittal; therefore any changes to these item~ after this date, including field modifications, must be reviewed by this office to insure continued conformance with applicable codes and standards. Please review carefully all comments attached as failure to comply with instructions in this report can result in suspension of permit to construct or install improvements. The item you have submitted for review has been approved subject to the attached conditions. The approval is based on plEins, information and/or specifications provided in your submittal. Please review carefully all comments attached, as failure to comply with instructions in this report can result in suspension of permit to construct or install improvements. Please resubmit to this office the necessary plans and_/ or specifications required to indicate compliance with applicable codes and standards. The item you have submitted for review is incomplete. At this time, this office cannot adequately conduct a review to determine compliance with the applicable codes a!'1d I or standards. Please review carefully all comments -attached. Please resubmit the necessary plans and/ or specifications to this office for review and approval. 1st 0205_3 2nd FD File# 3rd Other Agency ID Requirements Category: . _;,;,.,-_ . ' Building Plan Page 1 Requirement: Pending 05.32 Additional Requirements or Comments Per the technical report, the following fire protection conditions are required for the high piled storage area -room 197: 1. Ceiling sprinkler density of .45 gpm over 2000 square feet or actual floor area of warehouse. 2. One level of in-rack sprinklers. Add this information to the plans. 03/06/02 •· BY ' G. OHANIAN RACK DESIGN & ENGINEERING CO. 3786 LA CRESCENTA AVE., SUITE 204 GLENDALE, CA. 91208 .TEL:(818)957-2980 FAX:(818)957-8603 -1. ~· ·' DATE SUBJECT STRUCTURAL CALCULATIONS OF STORAGE RACKS FOR: ISIS PHARMACEUTICAL 1891 RUTHERFORD RD. CARLSBAD, CA. PER USC . 1 997 EDITION STORAGE RACKS CAPACITY: 1000 # / LEVEL CALCS. 1 THRU 4 DRAWINGS: RD 6482 •,,l., SHEET NO. JOB NO. RD-6482 , BY • G. OHANIAN ""' <...· DATE 1-17-02 SUBJECT 'b ... N . "' "' ,- to "' lo "' ,,-- lo "' ,,-- lo "'. .-- lo ... .-~v 96" .. SEISMIC DESIGN V= 2.5xCaxl x W Rx 1 ·4 woRKtNG . S~RESS 1=1 l RACK DESIGN & ENGINEERING CO. 3786 LA CRESCENTA AVE., SUITE 204 GLENDALE, CA. 91208 TEL:(818)957-2980 F.I\X:(818)957-8603 815 BEAM SHEET NO. JOB NO. SEAMS HER LEVELS fa, 1000 #/LEVEL+25% IMPACT 500 #/BEAM lx=l.84 Sx=.85 KSI. Fy=50 u K "K M= 96 x.5 = 6 8 "K SR= io = .2<.85 2 RD-6482 r 5 SEAM l LEVEL 3 t:i. = 5xWxl = ,2" <_J!§__= _53., -384xlx xE 180 , . -"Z" BEAM KSI. Fy=50 3 A = 5xWxl = .5" <_J!§__= .53" LABC 1999 SEC. 2222 384xlx xE 180 R=S.6 R=4.4 Ca=.44 W=D.L.+L.L. LONGIT. DIR. (MOM. CONN.) TRANSV. DIR. (BRACED) LOAD PER COLUMN P= 5x1 K =2.5 K 2 K' W=. 1 +2.5 =2.6 O,l, l.L. V = 2.5x.44x2~6= ,36 K LONGIT. 5.6X1 ,4 v = 2.5x.44x2.6 = _47 K TRANS. 4.4X1 ,4 LONGIT. SEISMIC . : co I") .13 K . 1 K ,06 K .04 K. ,03 K 2.3 "K 2.3 "I( 4 "I( 4 "I( 5 "I( 5 "K 6 "K 6 "K 8.3 "K ,_ BY · G. OHANIAN ,,. .... ~DATE 1-17-02 RACK DESIGN & ENGINEERING CO. 3786 LA CRESCEN.TA AVE'., SUITE 204 GLENDALE, CA. 91208 SUBJECT _ TEL:(818)957-2980 fAX:(818)957-8603 COLUMN ANALYSIS • 2 J/4". • f~ l 1 IC X ---X ~ 1 ... 09• KSI Fy=SO A=,7 Sx=,66 rx=l.22 ry=.89 c;oM~INED STRESS RATIO Pp+ MM = 216.6 + 280.3 ::: .6<1.33 a · ax BASE PLATE ANCH. TENSION ::: 8·3"K -(2·6Kx3") ::: , 1 K 6" ANCHOR SHEAR= ~ = .18K 2 (4)-1/2"!1S WEDGE TYPE ANCHORS ICBO #4627, OR #1372. (NO INSPECTION REQ'D) DESIGNED FOR 1 /2 STRESS MOMENT AT BEAM CONNECTION M, ::: 8.3 +6 2 = 7.2 "K 7 /16"9' RIVET Kl_ -4L-40 rx -1.22 ..,. Kl= ~=52 ry .89 USE 4 PIN CONNECTOR ALL LEVELS TYP. A= .095 KSI Fy = 79 4 PIN CONNECTOR K. " 32"K Ma ::: 6 x4 x1 .33 ::: CONN, K Va = .095x79x.4 = 3.0 K 2,6 .. ... .. . . . 6" 8" 0 0 0 0 ~ .. 8,3 SHEET NO. JOB NO. 3 RD-6482 Fe= ic.xE_= 106 (.K!)2 ry Fy KSI F0 =Fy(1-4Fe )= 44 K P0 :F0 xA = 31 P = __En_ = 1 6 K 0 1.92 . . ... 7.2 "K BY ._...,. DATE ·G. OHANIAN .. 1-17-02 SHEET NO . JOB NO. 4 RD-6482 SUBJECT RACK DESIGN & ENGINEERING CO. 3786 LA CRESCENTA AVE., SUITE 204 GLENDALE, CA. 91208 TEL:(818)957-2980 FAX:(818)957-8603 TRANSVERSE SEISMIC (OVERTURNiNG) . ~ " , Mor= .47 x2x240 x.5x1. 15 = 130 K 11 "K MR = 2.6 x36 = 94 UPLIFT=(130-94)/36"=1 4 ANCHORS Pa=2.4> 1 LOAD TO DIAGONAL K P = .94x 46 = 1.2 36 KSI Fy=50 . A=.52 rx=.48 L= 46" KSI Fa= 15.8 K Pa= 8.2 5/16"121 GR •. 5 BOLT K Va=l.5 x2=3.0 CHECK. SLAB 2600 f ,"1 ., • ., .. ., 9.5" 19" ., • ,d 5" CONCRETE SLAB 2000 PSI. CONC. 1000 PSF'. SOIL .. ., • 5.7" 3.8" 9.5" 1" 111 = rn £0-x t=.06" SEC. A-A ' 2600 ° 1000 =2·6 -J375 =19" fi ' 5/1 s"ra GR. 5 BOLT SEC. 8-8 a" 2.6x144=375 I st I I I I I I I I I 2 "# M= (__J_JL) xl 000x ..L x12 = 601.6 12 . 2 2 S= 12x5 =SO 6 601.6 = 12 < 1.6 -J 2000 =72 50 BY .. ~• ~ DATE G. OHANIAN 1-18-02 Sl!BJECT RACK DESIGN & ENGINEERING CO. 3786 LA CRESCENTA AVE., SUITE 204 GLENDALE, CA. 91208 TEL:(8l8)957-2980 FAX:(818)957-8603 STRUCTURAL CALCULATIONS OF STORAGE RACKS FOR: ISIS PHARMACEUTICAL 1891 RUTHERFORD RD . . CARLSBAD, CA. PER UBC 1997 EDITION STORAGE RACKS CAPACITY: 1 000 # / LEVEL CALCS. 1 THRU 4 DRAWINGS: RD 6482 SHEET NO. JOB NO. 1 R0-6482 i I 1 i• ' ,, BY ·G. OHANIAN '--•/DATE~· 1-17-02 SUBJECT r 95• . "' .., .-'-. "' .., ,..._,,.. ~ ,.---- lo "'. 'Ir-- lo .., .---- lo .. ----' ~ u .. SEISMIC DESIGN V= Z.5xCaxl x W Rx 1 .4 w6RKING STRESS 1=1 1 , RACK DESIGN & ENGINEERING CO. 3786 LA CRESCENTA AVE., SUITE 204 GLENDALE, CA. 91208 TEL:(818)957-2980 FAX:(818)957-8603 815 BEAM SHEET NO. JOB NO. flr1 BEAMS HER LEVELS 1000 #/LEVEL+25% IMPACT 500 #/BEAM lx=l .84 Sx=.85 KSI. Fy=50 n K "K M= 96 x.5 = 6 8 "K SR= 1o = .2<.85 2 RD-6482 ~ 5 BEAM l LEVEL 3 6. = SxWxl = _2 .. <_Ji§_= _53,. . .-, LABC 1999 SEC. 2222 384xlx xE 180 "Z" BEAM lx=.38 Sx=.3 Fy=50 KSI. 3 6. = 5xWxl = .S" <_Ji§_= _53,. 384xlx xE 180 R=5.6 R=4.4 LONGIT. DIR. (MOM. CONN.) TRANSV. DIR. (BRACED) Ca=.44 W=D.L.+L.L. LOAD PER COLUMN P= 5x1 K ~2.5 K 2 K W=. 1 +2.5 =2.6 _O.L. L.l, v = 2.5x.44x2.6 = _36 K LONGIT. 5.6X 1,4 v = ;2.5x.44x2.6 = _47 K TRANS. 4.4X1 .4 LONGIT. SEISMIC --1· .-. .13 K 2.3 "K . 1 K 2.3 "K 4 "K .06 K 4 "K 5 "K .04 K 5 "K 6 "K .03 K 6 "K 8.3 "K BY ·G. OHANIAN .,_,_, .), DATE SUBJECT 1-17-02 RACK DESIGN & ENGINEERING CO. 3786 LA CRESCENTA. AVE., SUITE 204 GLENDALE, CA. 91208 TEL:(818)957-2980 FAX:(818)957-8603 COLUMN' ANALYSIS • 2 3/4" • f~ 1· l "' -X ---X ~ t•.09" KSI Fy=50 A=.7 Sx=,66 rx =1.22 ry=,89 COMBIN_ED STRESS RATIO _BASE PLATE "K K ANCH. TENSION = 8·3 . -(2·6 x3") = .1 K 6" ANCHOR SHEAR = ~ = . 18 K . 2 (4)-1 /2"¢ WEDGE TYPE ANCHORS ICBO #4627, OR #1372 •. (NO INSPECTION REQ'D) DESIGNED FOR 1 /2 STRESS MOMENT AT BEAM CONNECTION u 8.3 +6 Ml: 2 "K = 7.2 7 /16"111 RIVET Kl -_AL -40 rx -:--1.22 - Kl= ~=52 ry .89 · USE 4 PIN CONNECTOR ALL .LEVELS TYP. A= .095 KSI Fy .= 79 4 PIN. CONNECTOR K Va = .095x7_9x.4 = 3.0 K 2.6 .. ... .. ... 6" 8" 0 0 0 0 SHEET NO • JOB NO. 3 RD-6482 Fe= zr..:xL: 106 ( Kl )2 ry Fy KSI Fn=Fy(l-4Fe )= 44 K Pn :Fn xA :31 P =__En__= 16 K 0 1.92 . . ·. ~ 7.2 "K K. · "K Ma = 6 x4"x1 .33 = 32· CONN. ~ ., 8.3 BY 'G, OHANIAN <1..-~ATE> 1-17-02 SUBJECT RACK DESIGN & ENGINEERING CO. 3786 LA CRESCENTA AVE., SUITE 204 GLENDALE, CA. 91208 TEL:(816)957-2980 FAX:(818)957-8603 TRANSVERSE SEISMIC (OVERTURNING) K " . ~ Mor= .47 x2x240 x.5x1.15 = 130 K n "K MR :::; 2.6 x36 ;:: 94 UPLIFT;::( 130-94 )/36";:: 1 4 ANCHORS Po=2.4> 1 SHEET NO. JOB NO. 4 RD-6482 LOAD TO DIAGONAL K P = .94x 46 = 1.2 I BT I KSI Fy=50 A=.52 rx =.48 L;:: 46" 36 KSI Fa;:: 15.8 K Pa;:: 8.2 5/16"!6 GR. ·5 BOLT K V0 =1.5 x2=3.0 CHECK SLAB 2600 I 4 <I 4 4 4 4 4 9.5" 19" 4 • <I 5" CONCRETE SLAB 2000 PSI. CONC. 1000 PSF'. SOIL 4 4 4 5.7" 3.8" 9.5" 1" 1" :N M7 £Ox t=.06" SEC. A-A , -=2"-"6=0-=0-0 = 2.6 1000 .J 375 =19" 5/16"111 GR. 5 . BOLT SEC. B-B . 0" 2.6x144=375 I I I I I I I I 2 "# M= (_JJL) x1 OOOx ..L ·X12 = 601.6 12 · 2 2 S= 1.2x5 =50 6 601.6 = 12 < 1.6 .J 2000 ;::72 50 DEL TA 3 PLAN REVISIONS for ISIS PHARMACUTICALS, T.I. PHASE Ill 1891 RUTHERFORD CARLSBAD, CA 92008 Prepared for: HOR Architecture, Inc. 9444 Farnham Street, Suite 300 San Diego, CA-92123-1300 Prepared by DEVINE ENGINEERING, INC. 12316 Oak Knoll Road, Suite C Poway, CA 92064 (858) 748-6168 February 1, 2002 Project #195.03 c/30(5313 " .K)B Is-,'1 TI /qS:dJ :·\-: DEVINE ENGINEERING, INC. SHEETNO. ,_ Li OF .,;t\ 12316 Oak Knoll Rd., Suite C )l1(_' I {l !L()L Powa~, CA 92064 CALCULATED BY. DATE (858 748-6168 CHECKED BY DATE SCALE ' ! ... : .... ···r··· . ···:······ .•.. t·· .... .... , ..... ! : l ' : . .... : ...... 1 .......... ..\ .... "·"t···. t · .. ..... ! ..... L ..... , .... ! ....... :.... ' "f--... '[" ...... : ....... j ......... i-....... 1 ...... !" .. ...... L ....... l ........ j ......... , ........ , .. 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'l'. · .. ; .. . ...... ! ... : ... · ... ·!·:.· ..... ·:·.· '.::::: ...... '. .......... l .......... '... .. : ... . ~ : ' . :. . ....... ! ......... : .. , : ": .. 1··· .:'.:.' !.;. ! .... ; ......... ! ...... ;" ....... / ..... , .... · 1 .... 3 .... -= · --~ ... -· ~ ·· -·· I ·· .. · f .. ; ···i·· : i .. , .. ; ........ -'. ··--··f· . ·l···· ; .... ' ' "J', DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd. Suite C Poway, CA 92064 (858) 748-6168 Max Span in Simply Supported Beam JOB T )J) TI. ( 11: 6J SHEET NO. G -& . OF---,-.----~- CALCULATED BY }'ii) L f: DATE / / 3 f / tJL ____ ;_.._______ '--'--t-, ----+-, --- CHECKED BY DATE _______ _ SCALE....,... _____________ _ Allowable Stress Design Member Type= -Mechanical Unit on Walkable Ceiling Joist 1200 S 162-54@ 16" O.C. C htA~(jt of. o"' S :l . 2 Tributary Width ft Dead Load psf Live Load psf E ksi I in4 S in3 Smax Safety Factor Fy ksi Deflection U w= 0.09 ' kif Vmax= 0.93 kips Deflection l.,max= 22.8 ft L\nax= 5wL4 384EI Moment Lmax= 21.8 ft Mmax= ~L2 8 I.max= 21.8 ft DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd. Suite C Poway, CA 92064 (858) 748-6168 Max Span in Simply Supported Beam Member Type= 1200 S 162-54 Joists Tributary Width ft Dead Load psf Live Load psf E ksi I in4 S in3 'Smax Safety Factor Fy ksi Deflection L/ w= 0.14 kif Vrnax= 1.17 kips Deflection Lmax= 19.5 ft Moment Lm~= 17.3 ft ~= 17.3 ft JoefS,J T[ · l°IJ',03 SHEETNO. ~--a;: OF _____ _ CALCULATED BY~t!!~l.-( ____ DATE~.....,../~J /....,..../_61 __ CHECKED BY DATE~----- SCALE~--------------- .t:imax= 5wL4 384EI Mmax= wl2 8 . _,. l ' DEVINE ENGINEERING, INC. ·12316 Oak Knoll Rd. Suite C Poway, CA 92064 (858) 748-6168 Max Span in Simply Supported Beam Member Type= Tributary Width Dead Load Live Load E I s Smax Safety Factor Fy Deflection U w= Vmax= Deflection Lmax= Moment Lmax= I.max= 1200 S 162-54 Joists 0.09 0.96 22.4 21.1 21.1 ft psf psf ksi in4 in3 ksi kif kips ft ft ft JOB I 5,1 TJ I 4LaJ SHEETNO. 4 _.. Ll. OF_-----=---...,.......,...,__- CALCULATED BY J41l,. ( DATE.__[:...,._/ S--'---'-f .... (=f).:;...__ CHECKED BY _______ DATE _______ _ SCALE ________________ _ ~ Stress Design fwC2Y Limax= 5wl4 384EI Mmax= wl2 a April 19, 2002 Abe Doliente Esgil Corporation 9320 Chesapeake Drive Suite 208 San Diego, California 92123 RE: Plan Check 01 3313, 1891 Rutherford, Carlsbad, California Subject: Amendment Number 4 (Revision 4) Dear Mr. Doliente: Thanks for your call regarding the Revision 4 drawings for the Isis Ibis Laboratory buildout project in Carlsbad, California. As you know this project was initiated this past fall in order to provide Isis Pharmaceuticals with new research and development space. The project has been constructed as a design build project. Field conditions and client changes In process have required several revisions of the plans as the project has neared completion. The project is currently 99% complete, with client occupancy of the building planned in the very near future. To support this ongoing effort in the field HDR and the various other consultant groups involved in the work have issued a total of four revisions to the plans for the work. The current revision is titled Amendment 4. Amendment four includes the follo_wing work elements. 1. Sheet G-102 and Sheet A-102 indicate the scope of changes proposed to the exit system for the laboratory space. During construction the width of the corridor changed to make the space shown as L, 121 no longer available for use as an exit system, (It was too narrow). A new exit path has been provided through the warehouse racking area of the space as indicated. 2. Sheet A-106 has been modified to show the door providing an exit path from the space as requiring panic hardware. 3. Drawings have been submitted by Crown Lifts to illustrate their warehouse racking system. 4. Devine Engineering has submitted a full set of structural drawings. Several new details have been added to that set. These details had been previously issued to the field to identify solutions to various structural field issues. Please let me know if you have any further questions, or require any further clarification. Best regards, Leaford L. Blevins, Ph.D. AlA Senior Project Manager 9444 Farnham Suite 300 San Diego, California 92123 Employee Owned Telephone 858 712-8400 Fax 858 712-8333 • / ', 01J f J\i ~ Cf-/ I "I } 67., -r~ ~ kt: _ c~ -c;; ~ VJ:r·CL) [;vy/1 ~ ~ '1i7 ~~ ~ ~ £/IA u ~~ ~, l.9-~n, () Cut~ ,:;} ~ {,M_ Vl........,.IY''~ /.-,,.-I a ~ ~utT:; £.. ~ ~ ~ V\ll-,_/\_A~ {) fl") ~ l;riday, April 26, 2002 7:42 AM Michael W. Devine 858-748-6011 p.02 X1·> Ib'°' JQB__:.:.::...,.-'~:.._ ___________________ _ SHEET NO. 5 -.& · DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd., Suite C OF·-----.----- DATE-s.-1/-1--/-2 (-l--/2_d_l_ ·. Poway, CA 92064 CALCULATED BV__;;m..;..;.._L~G.__ ____ _ (858} 748-6168 CHECKED av __________ _ DATE-------- SCALE ; _-! !~Jt,~.~!w~uj ~i t;:~iij~ ~1a_ (l;; ......... t 1 : ;1.QLi~t ... .:!;Jf;De~q\ ,' ......... : ; .... ) .. : ..... o •• -·· 1--... ( ...... ·-i "1"'"'"'i .. : ... ;. ..,: ...... ···r ..... 1 '.,,,;$tr..~/ : ...... ;. ; .. ;.,, .... t ~ ; .. ' ' . ' . . ... ; . 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'l I I -: . .-\~·· .. 1s,s PHARMACEUTICALS • 1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS • IBIS LAB BUILD-OUT Isis Pha1"111aceuticals -Ibis Lab Build-Out 1891 Ruthelford -Carlsbad, California Technical Report Hazardous Materials & Storage Operations Uniform/California C_odes Analysis 14 December 2001 [Rev. 2) Prepared by TEriks~m-Rattan Associates Inc. 4719 Palm Avenue La Mesa, California Telephone 619.466:6285 FAX 619.466.6233 EMAIL MaryRattan@thecoderesource.com0r MaryRattan@covad.net This report_ is the property of Eriksen-Rattan Associates Inc. and was prepared exclusively for·use by Isis Pharmaceuticals for the · operations & conditions described in this report. Only Isis Phatmat:euti~ls-for occupancy classification and the 1997 Uniform/1998 California Codes conditions & requirements addressed in this re_port shall utllizll! copies of this report. This report shall not be used for the purpose of coni;truction for.~is pn;,J~ or any other project or for any other purpose. I I i J 1. l I -I I . i ~ I I ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFQRNIA CODES ANALYSIS -IBIS LAB BUILD-OUT OVERVIEW Eriksen-Rattan Associates Inc. prepared this Technical Report for the exclusive use of Isis Pharmaceuticals for build-out of the 1st floor Ibis laboratory operations in their existing facility located at 1891 Rutherford in Carlsbad, California; The building is an existing, fully sprinklered, 2-story building which was modified by Isis in 2000 for rel'acation of part of the 'Ibis Lab operations.1 This report add.resses Uniform/Ca/ifomia Code requirements and conditions applicable to new hazardous materials conditions associated with the Ibis Lab build-out, with reference ·to existing hazardous materials t. 2,3,4 opera ions .. The existing building is currently designed as a single [one] Control Area, with the proposed tenant improvements creating an additional Control' Area for chemical waste storage. For the purpose of this report, the.new chemical waste storage area [Rooms L114 & L117] is designated as Control Area 1, with ' the balance of the building designated as Control Area 2, with Control Area 2 containing both existing and new laboratory operations. 5•6 The format of the report is as follows: •• ,f~~~*~~~jti~~~~li~Suti iiii:W~"?-1;.fi;·I.;1;;1;;:,tt:l;-t-ii:~~,~t:.1~~1. 2.0 3.0 Exhaust Ventilation System Conditions-Control Area 2 Class I, II & Ill-A Liquids -New Tenant Improvement Locations ··.4.0 CodeAnal Is 1 2 3 1Existlng Hazardous Materials & Storage Conditions: The existing laboraiory & warehouse operations in the building were addressed in a 6-1-00 Technical R~port prepared by Eriksen-Rattan Associates Inc. for Isis Pharmaceuticals. The City of Carlsbad Building & Fire Departments previously accepted this report, with tenant improvements represented in the report previously approved and permitted by the City of Carlsbad Building & Fire Departments. 2Applicable Codes: The 1997 Unifomt/1998 California Codes have been used as the baseline for requirements and conditions applicable to this project. 3"Rev. 1" Changes: the ·Rev. 1" changes were made in November 2001 in response to Esgil plan review comments regarding Control Area 1 /Room L 114 use operations, Combustible Dusts and Pyrophorics use and storage operations, and-conditions unknown when the 9-25-01 report was prepared. These changes were previously submitted to the-City of Carlsbad for approval and permit. 4"Rev. 2" Changes: The ·Rev. 2" changes are. the current changes addressed in this report, with changes appearing on pages 1, 6, 7, 14, 43, 44, 45. These modifications address changes in storage conditions and fire r,rotection in the warehouse storage area [Room 197]. Control Area Conditions: The building can be addressed as a single [one] B/S1 Occupancy Control Area based oh the types and amounts of hazardous materials that will be located. in the building. See Attachment 1 for , hazardous materials inventory information. 'Tenant Improvements Plans & Construction Documents: Refer to pl1;1ns and construction documents submitted separately, through Mansour ArchitE!ctural Corporation. Review of plans and construction documents for compliance . with the code requirements and conditions addressed in this report is-outside the scope of this report. • . ii I I ·, ~ I: I ! 1- 1 i ft. ... ~1 I· -. ~ I ·~ , .. f ~ i-:· !t~ \~1\· I I I 11 ~d I I :1 ISIS PHARMACEUTICALS • 18.91 Rutherford, -Carlsbad CA -UNIFORM/CALIFORNIA CODES ANAL Y$1$ -IBIS LAB BUILD-OUT Qt,Jestions concerning Isis Pharmaceuticals operations should be directed through: · Isis Pharmaceuticals L1;1eWillmon 2292 Faraday Avenue Carlsbad, California 92008 Telephone 760.603.2450 FAX 760.603.2600 EMAIL lwilltnon@isisph.com INFORMATION Question~ concerning building plans for the tenant improvements addressed in this report should be directed through: HOR Architecture Irie. Leaford Blevins 9444 Farnham Street -Suite 300 · San Diego, California 92123-1300 Telephone 858.71i.8372 Mansour Architectural Corporation Tony Mansour 5877 Oberlin Drive -Suite 111 San Diego, California 92121 Telephone 858.558.1509 FAX 858.558.9221 EMAIL tmansour@mansourarchitecture.qom Questions concerning this report should be directed to: T Eriksen-Rattan Associates ·Inc. Mary Eriksen-Rattan · 4179 Palm Avenue La Mesa, California 91941 Telephone 619.466.6285 FAX 619.466.6233 _E:MAIL MaryRattan@thecoderesource.com Discrepancies between this report and actual plan and field conditions are the sole responsibility of Isis Pharmaceuticals. iii I I ! I I I I I ISIS PHAR~ACEUTICALS -18.91 Rutherford, Carlsbad CA UNIFORM/CA,LIFORNIA CODES ·ANALYSIS -IBIS LAB BUILD-OUT TABLE OF CONTENTS ·SECTION .. -SUBJECT. .. .. .. . .. ~·. ,·--:-:~ .. · .. :.': : ·.PAGECSr-.·. : . .. .. .. • . 1.0 Scooe 1' 2.0 Hazardous Materials & Storaae Ooerations 2-7 3.0 -Exhaust Ventilation System Conditions -Control Areas 1 & 2 8-10 Class I, Ir & Ill-A Liaulds -New Tenant Improvement Conditions 4.0 · Code Analvsls 11-51 Table-4.0B Hazardous Materials & Storaae Oaerations f_or Tenant linarovement Conditions 12-51 1 Occupancv & Control Area Conditions 12 2 · Occuoancv & Control Area Seoarations 13 .3 Draft Curtains and Smoke & Heat Ventina 14 .4 Seoaration of lncomoatible Hazardous Materials & Conditions 14-15 5 General Area Ventilation svstems 16 6 Exhaust Ventilation System &:Explosion Control -Class 1: IJ:& Ill-A Liquids -Control 16-17 Areas 1 &2 7 ·Class 1 Product Conveying Exhaust Duct System -Class I, II & Ill-A Liquids -Control 18-21 · Areas 1 &2 8 Class 5 Product Conveying Exhaust Duct Systems -Corrosives -Exhausted 22 Hoods/Enclosures. & Gas Cabinets -Control Area 2 9 Exhausted Fume Hoods/Exhausted Enclosures &·Gas-Cabinets 22-23 10 Electrically classified Areas-Class I Flammable Liquids in Use & Transfer & 23-25 Flammable Gases 11 Earess Svstem 25-30 12 ·Liauid Transfer Ooeratiohs -Hazard Rankiria 3 & 4 Liauids -Control Areas 1 & 2 30-31 · 13 Pioiha Valves & Fittinas -Comoressed Gases & Crvoaenic Fluids·-Control Area 2 31-33 14 Limit Controls -Hazardous Materials 34 .15 · Soill Control, Drainaae & Containment-Hazardous Materials 34 16 Comoressed Gases & Crvoaenic Fluids -Control Area.2 34-38 17 Eauipment, Machinerv, Tanks, Vessels & Processes-Hazardous Materials 39 18 . lanition Source Control 39 ·19 Liahtina . 40-41 20. Fire-Sprinkler Svstem 41-43 21 Portable Fire Extinauishers 44 22 Water Suoolv -Fire Sorinkler Svstem & Fire Flow 44 23 Fire Department Access 44 24 Material Handlina & Transnnrtation in Buildina -Hazardous Materials 44 25 Storaae Ari'anaements -Hazardous Materials 45 '26. Approved Storage Cabinets, Gas Cabinets &·Exhausted Enclosures -Hazardous 46-57 Materials 27 Hazard Identification Sians 48 28 Premises Identification 49 29 · Emeraencv Resoons"El, Trainina & Procedures 49-50 30 Soecial Use Fire Department Permits 51 . .. _ ~"t~~~..;,,,. ' ~jnffloui:iMafirtila;Jliiv.iiitmil~alVlilS:-fi1';~~.\'1'.'lj;,;~zi~1'~~~i'>:i~:i'~~~~,H~~1".t1'"!~'1'-~':;; 1.-A Control Area 1 1-A1 Suminarv & Exempt Amounts 1-7 1-A2 lnvenforv Itemization -Alohabetical bv Material Name 1-2 1-B Control Area 2 1-81 Summarv & Exempt Amounts 1-21 1-82 · lnventorv Itemization -Alohabetical bv Material Name 1-47 1-C Definitions for Abbreviations 1 "'"0-:'.t~~~~· '~«r·v,a1 'tiii1ll!l&:'2~-·ffll' · ..... ·ib1 · Ya00f·Exn~·-·st:Vi .... unli: -·,.,c · ... dlfi"""·-~,1·r-· ·· · wr:il""'~~.,~ :;@~.~ , . .. . n 1 • . . ,,,_ o amma a,_, , au , en a Qn-. on ons., .,,., .. !~-~ , , .... ··• "'. t~~~~~~~ ~ifffiltfonimJemii(SDicmcffi>1sli~h•miaciutica1i.ODiiratrons:~~~;;J~1~;'~\f .. . .. . iv ,.,1., ~--- .... ··. 1:·_\/" I i -I I I I I I I"-:,,;,. I ... ~ ~ I I I I I ..,-.,; I .. I I ISIS PHARMACEUTICALS • 18.91 Rutherford, ·Carlsbad CA UNIFORM/CALIFORNIA CQDES ANALYSIS • IBIS LAB ,BUILD-OUT TECHNICAL REPORT HAZARDOUS .MATERIALS & STORAGE OPERATIONS CODE· REQUIREMENTS & CONDITIONS 1.0 Scope Eriksen-Rattan 'Associates Inc. prepared this Technical Report for the exclusive us.e of . Isis Pharmaceuticals for build-out of the 1st floor Ibis laboratory operations in their existing facility located at 1891 Rutherford in Carlsbad, California. The building is an existing, fully sprinklered, 2-story building which was modified by Isis in 2000 for relocation of part of the Ibis Lab operations.1 This report addresses Uniform/California Codf3 requirements and conditions applicable to new hazardous materials conditions associated with the Ibis Lab build-out, with reference to existing hazardous materials operatibns.2•3•4 The existing building is currently designed as a single [one] Control Area, with the proposed tenant improvements creating an additional Control Area .for chemical waste storage. For the purpose of this report, the new chemical waste storage area [Rooms L 114 & L 117] is designated as Control Area 1, with the balance of the building designated as Control Area 2. Control Area 2 will contain both existing and new laboratory operations.5•6 The format of the report is as follows: Section 2.0: Isis Pharmaceuticals hazardous materials and storage operations are addressed in Section 2.0. Section 3.0: A proposed alternate method of compliance to allow use of local exhaust ventilation in locations where Class I, II or Ill-A Liquids will be used is addressed in Section 3.0. Section 4.0: Code requirements and conditions applicable to Isis Pharmaceuticals hazardous materials and storage operations are addressed in Section 4.0. 1Existing Hazardous Materials & Storage Conditions: The existing laboratory & warehouse operations in the building were addressed in a 6-1-00 Technical Report prepared by Eriksen-Rattan Associates Inc. for Isis Pharmaceuticals. The City of Carlsbad Building & Fire Departments previously accept~d this report, with tenant improvements represented in the report previously approved and permitted by the City of Carlsbad Building & Fire Departments. 2Appllcable Codes: The 1997 Uniforin/199(! California Codes have been used as the baseline for requirements and conditlons applicable to this project. 1"Rev. 1" Changes: The MRev. 1" changes were maqe in November 2001 in response to Esgil plan review comments regarding Control Area 1/Room L 114 use operations, Combustible Dusts .and Pyropl:torics use and storage operations, and conditions unknown when the 9-25-01 report was prepared. These changes were freviously submitted to the City of Carlsbad for approval and permit. "Rev .. 2" Changes: The MRev. 2" changes are the current changes addressed in this report, with changes appearing on pages 1, 6, 7; 14, 43, 44, 45: These modifications address changes in storage and fire sprinkler system prot~ction conditions in the warehouse storage area [Room 197]. Hazl:lrdous materials and Control Area conditions remain unchanged. . 5Control Area Conditions: The building can be addresse~ as a single [one] B/S1 Occupancy Control Area based ~m the types and amounts of hazardous materials that will be located in the building. See Attachment 1 for hazardous materials in.ventory information. ._ , 'Tenant Improvements Plans & Construction Documents: Refer to plans and construction documents submitted .separately through Mansour Architectural Corporation and/or 1-iDR Architecture Inc. Review of plans and construction documents for compliance with the code requirements and conditions addressed in this report is outside the scope ofthi~.report. 'f'E.riksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical .Report -Hazardous Materials & Storage Operations Code-Requirements & Conditions -12/14/01 [Rev. 2] -Page 1 of 51 ' ' I I I I i 1· j I :··1 M j ., t\ ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA ' . . -' UNIFORM/CALIFORNIA CODES ANALYSIS -1e1s· LAB BUILD-OUT 2.0 Hazardous Materials & Storage Operations General Conditions: • Build-out of the Ibis Lab will essentially involve an expansion of the existing R&D laboratory operations located on the 1st floor and constructing a new 1st floor chemical waste storage area, with the building, now on~ [1] buHding Control Area, divided into two [2] building Control Areas. Table ~.0 on page 3 provides an overview of both the existing and new 1st floor hazardous materials and storage operations. [NOTE: There are no existing or proposed 2nd floor hazardous materials or storage operations.] • Rooms/areas not listed or identified in the table will not have any hazardous materials or storage conditions that are specifically regulated through the Untform/Califomia Building & Fire Codes. • Refer to plans and construction documents submitted separately through Mansour Architectural Corporation or HDR Architecture Inc. for tenant improvement details. • Refer to previously approved and permitted plans for existing conditions. Combustible Dusts -Control Area 2: • A small amount of combustible dusts [Poly(Vinyl Alcoliol}/0.5507 pc,,unds and nickel Powder/2.3347 pounds] will be used and .stored in Control Area 2, with less than 10% of either material in use at any location at any time. • The materials will nofbe manufactured on the premises, and the materials will not be used or generated in such a manner that concentrations and conditions create a fire or explosion potential. • The materials will be stored in closed containers. • The materials will not be exhausted through exhaust duct systems in the "dust" form. • No special "dust" controls are required, based on the Isis conditions described above, and as established in UBC/CBC Sections 304.8 anc! 307 .1.1, UFC/CFC Article '76 and UMC/CMC Section 505. Pyrophoric Liquids .& Solids -Control Area 1: • Pyrophoric liquids [0.4447 gallon] and solids [0.0022 pound] will be used and stored in Control Area 2. [Pyrophoric Liquids: Butyllithium, DiisobutylaluminumTriethylborane, Triethylphosphine, Trimethyl Aluminum; Pyrophoric Solids: Lithium Diisopropylamide] • All use of such materials will be in closed systems, with <10% of any material in use at any location in use at any time. • Storage will be within approved hazardous materials storage cabir:1ets, as indi~ated in Attachment 1 B, with storage of >/=0.05 gallon of Pyrophoric liquids required to be in such storage cabinets as · indicated in Table 4.0B/ltem 26. Storage in Approved Cabinets -Control Areas 1 & 2: • Referto Attachment 1 for materials that Isis has indicated will be stored in approved flammable Jiquidsihazardous materials storage cabinets [Control Area 1/Attachment 1A2 and Control Area 2/ Attachment 1 B2]. • Conditions specifically requiring storage in apprc;,ved cabinets to maintain Control Area Exempt conditions are as follows and as described in Table 4.0S/ltem 26: ·• + Control Area 1: Storage ih cabinets not specifically required. • Control Area 2: Flammable Liquids I-B >/=22 gallons; Pyrophoric Liquids >/=0;05 gallon; Unstable Reactive 3-Liquids >/=0.06 gallon TEriksen;Rattan Associates fnc. 4719 Palm Avenue, La Mesa CA 91941 Technical.Report-Hazardous Materials & Storage.Operations Code Requirements & Conditions --12/14/01 [Rev. 2J -Page 2 of 51 mt -- ··-i;s~ 'd.E'-~~ .,,,, ... IIIIL· '111111. ·-,-·.··, L. ~ ~ {,="~: . ~...;:..,.$ , ·-,-_...: .. _.,.;; r~:,.iJ --·.,.,,·~. ·-J .. -;-. __ , _____ _ ISIS:PHARMACEUTICALS -1891 Rutherford, Carlsbad' CA UNIFORI\II/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT B&S-1 Not applicable -Control Area 1 will be created as part of the tenant Improvements. • L114 & L117: Chemical Waste St~ge · • L 114: Liquid Transfer from </=4-Llter Containers See Attachment 1-A for hazardous materials inventory Information. • Drum Storage: I L114 & L117 • </=30-gallon capacity • Floor storage • 1 drum high • Container Storage: • </=20-liler capacity • Floor and/or shelf storage @ </=6' above finished floor. • Lips/guards on shelves If.individual container storage. • Class I, II and/or Ill-A liquids: • l114: • Storage & liquid transfer • Liquid transfer of </=4-llters into </=30- gallon dl'l!ms. • Liquid transfer operations inside walk-In-exhausted enclosure/fume hood· • L117: Storageonly- no liquld transfer. TEriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page 3 of 51 .. ,. ~ --cw V{f' . ' ~ . . ~-~';$ . t~~-·-·~-~ . -~ --~~ ~J ma.; IIIIIIJ ----··.--ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNlfORM/CAl..lFORNIA CODES ANAL ys1s -IBIS LAB BUILD-OUT [continued on next page] Robotics SclntillaUon Lab Magnet Room •Eriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 • General: Hazardous materials use & storage I L 101 • Ciass I, II and/or Ill-A. Liquids Use/ Transfer: None. • Storage Height: Floor andlor shelfstqrage @ <1=6' above finished floor +Liquids: • Containers -<I=20-liter capacity • Lips/guards on shelves If Individual container storage. • Compressed Gases: • Cylinders -<1=100- pound capacity • Floor storage or ay be piped Into room.from adjacent lab • Cryogenic Fluids: • Containers ->I=45- gallon ~paclty •. Floor storage or may, . · be piped into roorri from adjacent lab Same conditions as described for Robotics I L 109 Scintillation Lab. Open Lab -Hazardous Materials Use & Storage See Attachment 1-B for hazardous materials Inventory information. . • General: Hazardous I .L 107 materials use & storage • Class I, II and/or Ill-A Liquids Use!Transfer: In exhausted laboratory fume hoods. • Storage Height: Floor andlor-shelf storage @ <1=6' above finished floor +Liquids: • Containers -<I=20-liter capacity • Lipslguards on shelves if individual container storage. • Compresse~ Gases: • Cylinders -<l::;100- pound capacity • Floor storage or may be ·piped Into room from adjacent lab · • Cryogenic Fluids: • Containers -<1=45 gallon capacity' • Floor.storage or may be piped Into room from adjacent lab Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14101 [Rev. 2} -Page 4 of 51 - --~-·-~:~ ·----~~-1 %""'·"" ~iiiiii w.,-c-.,, · rt.-~---~--·· ~.tSf'" C!:11111111~ .. ----llllli--,.:_~;,-.~-~; -.:0 llliiiilJ .-.:; W .. ----- ... ~ ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES AN.AL YSlS -IBIS ·LAB BUILD-OUT B&S1 [continued] Mass Spectrometly Lab TEriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Same conditions as described for Robotics L110 Scintillation Lab, except as follows: · + Class I-B Flammable Liquids, with use in exhau.sted laboratory fume hood(s). • Cryogenic Fluids: Piped to use locations/Rooms L 101 & L 109, with containers stored on the floor. I Same conditions as Equipment Labs described for Open Lab 1· L 120 107, except as follows: See Attachment 1-B for • No use of Class I, II or Ill- hazardous materials A Liquids. Inventory Information. BSL-2 Labs Same conditions as L115&L116 described for Open Lab See Attachment 1-B for: 107. hazardous· materials inventory.Information. Glasswash Lab· I Same.conditions as described for Open Lab I L113 107, except as follows: See Attachment 1-B for · 1 • No use of Class ·1, II or Ill- hazardous materials A Liquids. inventory information. • No compressed-gases. • No cryogenic fluids. Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 (Rev. 2)-Page 5 of 51 I - •, • ,~I .. -- ;; .. -~. ~:-~---m--~ • r..: •••• ..,... ~..-w........ {"·"-':-··; ·,-·; -··;\\ --: -·· l:a.."l..::'"~ ... ~--• y,<:.n.d llmlll-»J ··-~ -ISIS PHARMACEUTICALS·-189,1 Rutherford, Carlsbad CA· UNIFORM/CAUFORNIA CODES ANALYSIS ~ IBI~ LAB. BUILD-OUT · s·1 I ~old ·Box & Refrigerator + Container Storage: • </=20-llter capacity L102 & L103 -1 Equlpm,nt Room Storage -Hazardous·& • Floor and/or shelf [ ti d I Non-Hazardous Materials !;torage @ <1=6' above con nue on next page] · finished floor. • Ups/guards on·shelves containing Individual containers WarehOl/se Storage -Non-[See tenant Improvement L 197 [197) Electrical Room Hazardous Materials changes on the next page - change from "ordinary" storage to high-piled combustible storage conditions.] - • Lab & facility support equipment/systems. +No hazardous materia!s conditions. • Lab & facility support equipment/systems. • No hazardous materials conditions. ... ··-"·'- I L112 L111 TEriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12114/01 [Rev. 2] -Page 6 of 51 - ---LIiii ~ --~f::r;J -:(~:;:--.... ~--:-~--~ -.,,.;~ 11111] llllliJ -; -(-,.-_ :ar.- ISIS PHARMACEUTICALS -1.891 Rutherford, Carlsbad CA , ' lJNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT S1 [continued] Warehouse Storage --Non- Hazardous Materials + Storage Commodities: • Class I-IV I L197 [197) • High Hazard -Group A/B ~la_stics -cartoned • Storage-Methods: • Floor -storage to </=6' above finished floor • Rack -storage to </=20' above finished floor • Shelf -storag~ to </=10' above finished floor + Stol'!lge Conditions: • Access: No public acces~ • Warehouse Storage Area: <1,500 sf • Storage Height: See «storage Methods" • Aisles: • Ma,in Aisles: >/=44" • Cross Aisles: >/=24" TErlksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2] -Page 7 of 51 _1 :·-:. I ~ 1. I :1 I I i ""'l I -1 ~ I I I I ~'J I I I ISIS PHARMACEUTICALS -18~1 Rutherford, Carlsbad CA UNIFORM/CALIF.ORN IA CODES ANALYSIS -IBIS LAB BUILD-OUT 3.0 Exhaust Ventilation Syst~m Conditions -Control Areas 1 & 2 Class I, ii & Ill-A Liquids Use in New/Tenant Improvement Locations Class I, .Ii and/or Ill-A Liquids will be used in both Control Areas 1 and 2, with use operations as follows and as described in Table 3.0A for Control Area 1 and Table 3.0B for Control Area 2. ~ Control.Area 1 -Room L 114: + Liquid transfer of </=4-liters into </=30-gallon containers/drums in Room L 114 [no use/transfer in Room L 117]. + Class I Flammable and Class II Combustible Liquid transfer-operations occurring within an enclosed, walk-in enclosure/fume hood, with exhaust ventilation provided at >/=1,000 cfm. • Control Area 2: + Existing, Previously Approved/Permitted Conditions -Lab ~ 110: • Closed & open system use conditions -</=0.028 gallon in open use/transfer at any time. • Use/transfer without exhausted enclosure or exhausted fume hood. + New/Tenant Improvement Conditions-BSL2 Labs [L115 & L116] & Open Lab [L107]: • Closed & Open system use conditions --</=0.2642 gallon in open use/transfer at any time. • Use/transfer without exhausted enclosure or exhausted fume hood. The proposed tenant improvement exhaust ventilation system conditions are consistent with the conditions previously approved and permitted in 2000 for relocation of the existing labs to the 1891 Rutherford facility. Refer to Attachment 1-A for flammable/combustible liquids use operations in. Control' Area 1/Room L 114. Refer to Attachment 1-B for flammable/combustible liquids use operations in Control Area 2 for both existing and new locations and conditions. Refer to Attachment 3 for nonflammable vapor exhaust ventilation calculations for conditions required to maintain vapor-air mixtures at </=10% and </=25% of their lower explosive/lower flammable limit. TEriksen-Rattan Associates. Inc. 4719 Palm Avenue, La fylesa CA 91941 Technical Report ..:.ttazardous Materials & Storage Operations Code Requirements & Cond_itlons -12/14/01 {Rev. 2] -Page 8 of 51 I I .I I :1 i i 1· I ···. ISIS PHARMACEUTICALS • 18.91 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS • IBIS LAB BUILD-OUT +L114 + Combustible Liquids II + Flammable Liquids I- A, 1-B & 1-C + Open system transfer • Transfer within exhausted walk-in · conditions. fume hood/enclosure. + Maximum open system use/ + Local exhaust ventilation within the transfer amount = 1 liter walk-in hood as an alternate [</=0.2642 gallon]. · method of compliance to general/ area exhaust ventilation for Room L114. · • Minimum cfm required to maintain vapors at </=25% LEULFL within the work area and to allow exhaust du~s to pass through otlier areas: 323.9177 cfm. + Minimum cfm required to maintain vapors at </=10% LEULFL to allow non-sprinklered !:)Xhaust ducts: 809.7943 cfm. ~ + NOTE: >/=1,000 cfm exhaust rovided: Table 3.0B -Control Area 2 -Class I, II & Ill-A L1qu1ds Use and Transfer Conditions ~~~~ Existing -Previously Approved & Permitted Cond1t1ons Labl110 · + BSL-2 Labs - Rooms L115& L116 +Open Lab...:. Room L107 Flammable Liquids 1-8 . • Combustible Liquids II & Ill-A + Flammable Liquids I- A, 1-8& 1-C TE.rikseri-Rattan Associates Inc. .4719 Palm Avenue, La Mesa CA 91941 + Closed and open system use conditions. +</=0.028 gallon in use/transfer at any time. · + Closed and open system use conditions. + Maximum open system use/ transfer amount = ·1 liter [</=0.2642 gallon]. + Existing previously approved and permitted conditions -use/transfer within exhausted enclosure or exhausted fume hood. +Refer to the 6-1-01 Technical Report referenced on page 1 and previously approved/permitted lans for details • Use within exhausted enclosures, exhausted fume hoods and/or walk- in exhausted enclosures/hoods or under exhausted hoods. + Local exhaust ventilation as an alternate method of compliance to general/area exhaust ventilation. • Minimum cfm required to maintain vapors at </=25% LEULFL within the work area and to allow exhaust ducts to pass through other areas: 479.8011 c;frn. + Minimum cfm required to maintain vapors at </=10% LEULFL to allow non-sprinklered exhaust ducts: 809.7943 cfm. Technical Report-Hazardous Materials & Storage Operations Code Requirements & Cond)tions -12/14/01 [Rev. 2] • Page 9 of 51 I I ; I . ) I I I I i . i I -~·-i ~. ,ll" .. H I t; I I I 1,c.J I I I ISIS PHARMACEUTICALS • 18.91 Rutherford, Carlsbad CA- UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT UBC/CBC Section 1202.2.2 requires general/area mechanical exhaust ventilation in Band S1 Occupancy ~teas in locations where Class I, II or Ill-A Liquias are used or transferred in an <?Pen system environment, with the exhaust ventilation sufficient to produce six [6] air changes per hour, with exhaust taken from a point at or near the floor level [within 12" of the lowest point in the room]. Isis Pharmaceuticals proposes to use local exhaust ventilation as an altemi)te method of compliance to general/area exhaust ventilation in the new tenant improvement locations identified in Table 3.0A/Control Area 1 [new Waste Storage Room L114] and Table 3.0B/Control Area 2 [new BSL-2 Labs/Rooms L11~ & ~116 and new Open Lab/Room L 107]. As indicated in Tables 3.0A and 3.08, local mechanical exhaust ventilation will be provided at locations where Class I, II or Iii-A Liquids will be transferred or used in an open system environment through one [1] or more of the following methods: • Use/transfer of Class I, II or Ill-A Liquids within exhausted laboratory fume hoods. • Use/transfer of Class I, II or Ill-A Liquids within exhausteci enclosures. • Use/transfer of Class I, II or Ill-A Liq1.,1ids under exhausted hoods. • Use/transfer of Class I, II or Ill-A Liquids within exhausted walk-in hoods/enclosures. The use of local mechanical exhaust ventilation is an alternate method of complian9e to the general/area exhaust ventilation of 6 air changes per hour addressed in UBC/CBC 1202.2.2. Local mechanical exhaust ventilation, designed and. installed to capture vapors at their point of generation, will provide a more effective method· for control of flammable and combustible liquid vapors than will general/area exhaust ventilation. This alternate method of compliance is hereby submitted and requested by Isis Pharmaceuticals in accordance with the provisions set forth in. UBC/CBC 104.2.B. The exhaust ventilation system conditions proposed for the new tenant improvement locations are consistent with the conditions previously approved ana permitted by the City of Carlsbad Building Department for the existing labs. . ' TEriksen-Rattan Associates Inc. 4719 Palm Aven.ue, La Mesa CA 91941 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2] -Page 10 of 51 . ·.·,. I I I -1 '•v I I I 1515 PHARMACEUTICALS -18.91 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAJ3 BUILD-OUT 4.0 CODE ANALYSIS The Code analY$iS that follows in Table 4.0B on pages 12-5_1 addresses applicable Uniform/California Building Code and Uniform/Califomia Fire Code conditions and requirements for the Isis Pharmaceuticals hazardous materials and storage operations addressed 1n Sections 2.0 and 3.0. Ttie report is specific to the tenant improvement conditions addressed in Sections 2.0 anci 3.0, with reference as applicable to existing conditions.7'8'9 Attachments referenced in Table 4.08 are as follows: Conciitions other than the conditions addressed or specifically addressed herein are outside the scope of this report. Discrepancies between the information presented herein and actual conditions and conditions presented on plans are the sole responsibility of Isis Pharmaceuticals. Verification of compliance with the Code requirements and conditions addressed herein is outside the scope of this report. Refer to plans and construction documents submitted separately throt.1gh Mansour Architectural Corporation or HOR Architecture Inc. for plans and construction documents applicable to the tenant improvement conditions addressed in this report. '.,Existing Hazardous Materials & Storage Conditions: The· existing laboratory & warehouse operations in the building were addressed in a 6-1-00 TechniCl:1I Report prepared by Eriksen-Rattan Associates Inc. for Isis Pharmaceuticals. Tnis report was previously acceptEld by the City ,of Carlsbad Building & Fire Departments, with tenantimprovements represented in the report previously approved !:ind permitted by the City of Carlsbad Building & Fire Departments. · 8Applicable Codes: The 1997 Uniform/1998 California Codes have been used as the baseline for requirements and conditions applicable to this project. · · 9Control Area Conditions: Th~ building can be addressed as a single [one] B/S1 Occupancy Control Area based on the types and amounts of hazardous materials that will be located in the building. See Attachment 1 for hazardous.materials inventory information, TEriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2] -Page 11 of 51 .. -- ,_ f:' it'-'·-· ~--r:-:,--'i""...._,,.,_ ... ·:-··· -·-··• .._;q _ . ~ 1( ~ &-~~"-' ,. .. ,,. _ _; __ _,..; .-cn-.J ~ ISIS PHARMACEUtlCALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA-CODES ANALYSIS -IBIS. LAB BUILD-OUT 111111'., - · 1. Occ~pancy & · Control Area Conditions • Occupancy Conditions: . ·• B: · • Office, administrative employee areas. • Occupancy Conditions: Same as Isis conditions. •Control.Area Conditions: Same· as Isis conditions: • Facility support rooms/areas. • Labs. • S1: • Equipment.& supply rooms. • Facility support rooms/areas. • General storage rooms/areas. • Hazar~ous materials storage rooms/areas. • Warehouse storage.[non-hazardous materials, Class I-IV Commodities, ordinary storage conditions]. • Control Area Conc;lltlons: • Number: Two [2] • Conditions: • Control Area 1: • New tenant improvement conditions. • Chemical Waste Storage.-Rooms L114 & L117 "' B & $1 Occupancy conditions [storage rooms, with liquid transfer in Room L 114]. • Control Area 2: • Existing & new tenant improvement conditions. • Balance of building not included in Control Area 1. • B & S1 Occupancy conditions. -:.- t UBC/CBC 204 + UBC/CBC 307 .. -·,, __ _ + UBC/CBC Table 3-B + UBC/CBC Tables 3-D & E + UFC/CFC 204 t UFC/CFC 209 . t UFC/CFC 7901.1 t UFC/CFC.7902.5 t UFC/CFC Table 7902.5-A t UFC/CFC 8001.1 + UFC/CFC 8001.8 + UFC/CFC 8001.15 + UFC/CFCTables 8001.15-A & B YErlksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page 12 of 51 - ·-1 --.. !i"t1lliililila ~'11iiiiiiaa =··-,,r,:-ll:'lliiilllllllilt"' ':"-· . . . . ., -' -h ---· -·, ~~ ~ ~ • -~:r. h•"~"·---:..~-·) -.v~ ~ -~ ; --.. -:,_ ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNI.FORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT 2. Occupancy & Control Area S~paratlons + Occupancy Separations: None required -8 & S1 Occupancy 1:9nditions. +Control Area Separations: 1-hourfire-resistive occupancy separation between Rooms L 114 & L 117 and the following adjacent areas: • l11.3 -Glasswash Lab • L 115-BSL-2 Lab • L 116 -BSL-2 Lab • 2nd Floor 'YErlksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 + Occupancy Sep_aratlons: Same as Isis conditions. + Control Area Separations: Same as Isis conditions, with 1-hour fire-resistive occupancy separations . complying with the following conditions, as specifically applicable to Isis conditions: • Vertical Separation -Walls: • 1-hour fire-resistive construction. • 1st floor, extending to 2nd floor. • Horizontal Separation -Floor between 1•1 & 2nc1 Floors: • 1-hourfire-resistive construction. • Includes structural members supporting the . separation. • Openings: • Doors: • 60-minute labeled self or automatic closil'!g assemblies. • Gl;:izing limited to 100 square inches, with a minimum dimension of 4 inches. "' Duct Penetrations: • Smoke Dampers: • At penetrations of occupancy/Controt·Area separation walls; or • Ducts located In 1-hour fire-resistive shaft; or • Alternate method of compliance acceptable to the Building Department. • Fire Dampers: • At duct penetrations of occupancyiControl Area separation walls and floors; or ·• Ducts located in 1-hour fire-resistive shaft; or • Alternate method compliance acceptable to the Building Department. • Smoke & Fire Dampers -Access: To-be accessible for inspection & servicing. • Windows: 60-minute labeled assemblies. • UBC/CBC 204 • UBC/CBC 302 : • UBC/CBC Table 3-B • UBC/CBC 307 • UBC/CBC Tables 3-D & E • UFC/CFC 7901.1 + UFC/CFC 7902.5 + UFC/CFC Table 7902.5-A + UFC/CFC 8001.1 • UFC/CFC 8001.10 + UFC/CFC 8001.15 + UFC/CFC Tables 8001.15-A&B Technical Report-Hazardous Materials & Storage Operations Code Requirements & CondiUons -12/14/01 [Rev. 2) -Page 13 of 51 -,. ... ---yr ... C?4-[;fi .lf.~~l'.-f/c-%'. -;:···--_-,-· '·': -··1 -·"'! --, .. , -,_ -· ---t.:. ~ .......__ -~¢.--'----~ -~ ~~ ~•·>-4,_,; __ _. w~~, , ~ ..! ~ .:. ~--. .... ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA l . UNIFORM/CALIFORNIA CODES ANALYSIS -_IBIS LAB· BUILD-OUT • ,:,f,,,-J:l.-'1!!._:@ ·~ .. 1$!'.£.'r.M~-, ... ,•,_"-('_•_·1•.cA ... t,,i .. i:;. ,_ ,;j,-,,,,,,C,,,~-.,'tl..:'°'i"'"~--·,•a•• 1·.s.: t·· -'~!::. _·s• "" ... _ ' ·. _., ___ .. ', ,,,,. ' . ,C---,. S,,,,,l !Ii ,~.J.-,"-';;.i11'.?~~,.L -Ss.~n.•ffl'JaC9.u ,..a S;l,',,0,h -~n. __ -,·:t·: ·: ·. ·. · : --.:!·:,··. · 1 3. Draft Curtains and Smoke &Heat Venting NOTE: Rev. 2 Changes 4. Separation of Incompatible Hazardous Materials & Incompatible Conditions [continued on next page) - + Undivided Building Area >5o;ooo sf: Not applicable · to Isis Pharmaceuticals Conditions --no undivided building area >50,000 sf. +High-Plied Combustible-Storage/Warehouse Area: Not applicable to Isis Pharmaceuticals Conditions --no high-piled combustible storage areas >/=2,501. sf •. + H Occupancies >15,000 sf: Not applicable to Isis Pharmaceuticals Conditions -no H occupancy conditions in the building. + Pow,ared Industrial Trucks/Forklifts: Not applicabie to Isis Pharmaceuti<:als conditions -no powered industrial trucks/forklifts. + Incompatible Hazardous Materials: • Control Area 1: Not applicable to Isis conditions - no incompatible material conditiens. • Control Area 2: • Acids $ Bases: Strong Acids [pH: <4] and strong Bases [pH: >1 OJ will be separated from each other. ··• Class i, II & Ill-A Liquids~ Class I, II & Ill-A will .be separated from: • Organic Peroxides • ·Oxidizers • Pyrophorics. • Unstable Reactlves 3 • Water Reactives 2 & 3 * Flammable $ollds: Flammable Solids will be separated from: • Oxidizers • Pyrophorics • Unstable Reactves 3 * Organic Peroxides: Organic Peroxides will be separated from: • Class I, II & Ill-A Liquids • Flammable Solids • Pyrophoralcs • Oxidizers • Unstable Reactives-3 • Water Reactives 2 & 3 Same a~ Isis conditions -not applicable. • Powered Industrial Trucks/Forklifts: Same as Isis conditions -not applicable. . + Incompatible Hazardous Materials: Same as Isis conditions --not applicable. · · t UBCICBC 906 + UFCICFC 8102.7 + UFCICFC 8102.8 + UFCICFC Tables 81-A & 81-B . + UFCICFC S~d 81-1 + UFCICFC 103.1.2 + l,IFCICFC210 • UFCICFC 1108 • UFCICFC 7401 + UFCICFC 7402 • UFCICFC 7902.3 + UFCICFC 7902.5.4· + UFCICFC 7903.3.3 + UFCICFC. 8001.11.8 + UFCICFC 8001.15.4 +OSHA: • CFR 1910,178 • CFR 1926.403 't'Eriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditlons-12114101 [Rev. 2] -Page 14 of_ 51 --- ,::-""J! V'l.'t!,-17~· ,;,.a-;.:}.S?-f>'.S,-"'''\-·,,-· -'! -i"'\ IIIIIJ' __ , , ----. -: • ~ ~;:! ~ fjf::fl{J t.l:...~~~ ........... _.: ~.:.._j -t>.d ~ • I ,' ,_ ~.. ~/.. - ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS • IBIS LAB BUILD-OUT ,_. = ·. ··, ~,cbHe~.co, --~1i1dfti~s-1t"'1%f:-:.~r~t~'.1W~:i11s1s '.P.ti~ __ -..·_ .... ,r ii_-., -'' ' .... , ,. •L_,I'),.,.' •' ,;,,,,~ '.,,l'. •>. ,.,,.,~m. ~- 4. Separation of Incompatible, Hazardous Materials & Incompatible Conditions + Incompatible Hazardous Materials -continued: [continued] 1"Eriksen-Rattan Associates Inc. • Control Area 2 -coritlnued: - • Oxidizers: Oxidizers will be separated from: • Class I, ·11 & Ill-A Liquids · • Flammable Solids • Organic Peroxides • Pyrophorlcs • Unstable Reactives 3 • Pyrophorlcs: Pyrophorics will be separated from: • Glass I, II & Ill-A Liquids • Flammable Solids • Organic Peroxides · • Uns~ble Reactlves 3 • Unstable Reactlves 3: Unstable Reactive 3 materials will be separated fr<>m: • All other physical hazard materials. • Water Reactlves 2 & 3: Water Reactives 2 will be separated from: • All other liquids. • Separation Conditions: Separation of incomp!3tible materials from each other will be by one [1] or combination of the following conditions: • Storage-in separate approved cabinets. • Storage in separate .rooms. • Isolating.incompatible materials storage by a non1:9mbustible partition extending >/=18" above and to the sides of the storage. • Segregating incompatible materials storage by a distance of >/=20'. • Special Conditions -Water Reactives ·2 & 3: Water Reactives 2 or 3, if located in the same room with Class I, If.or Ill-A Liquids, will be stored in an approved storage cabinet. 4719 Palm Avenue, La Mesa CA 91941 • Pow,red Industrial TrucksiForkllfts: Same as Isis conditions ---not applicable. + Incompatible Hazardous Materials: Same as Isis conditions-not applicable. + UFC/CFC 103.1,2 + UFC/CFC 210 + UFC/CFC 1108 + UFC/CFC 7401 +-UFC/CFC 7402 + UFC/CFC 7902.3 + UFC/CFC 7902:5.4 + UFC/CFC 7903.3.3 . + UFC/CFC 8001.11.8 + UFC/CFC 8001.15.4 +OSHA: • CFR 1910.178 • CFR 1926.403 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2] -Page 15 of 51 - ---r.'--~ lf":1'..,_im--'~"-"'''f.<' •''JIIIL'·,-·, _,,,, ..... I --; -;-·--· ·, ---t:=--WW· u;,,.;, • .._..~-~:is' "--= _J ,,,,,;., ~ ~ . . . ,_ .... ·~·· - ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS ... IBIS LAB BUILD-OUT 5. General Area Ventilation System 6. Exhaust Ventilation System & Expioslon Control - Class I, II & Ill-A Liquids -Control Areas 1 &2 . [continued on-next page] • Types: Mechanical ventilation or combination of -I Same as Isis conditions. mechanical & natural ventilation. • Mechanical Ventilation: • Capable of supplying >/=15 cfm of outside air per occupant in all portions of the building during the time the building is occupied. • Registers located >8' above the floor where the air velocity is >10 fps. • Natural Ventilation: •· Openable exterior openings -area >./=1/20 of total floor area. • Exterior openings, which open directly onto a yard. • Use Conditions: • Control Area 1:· TransferofClass I & II Liquids in Room L 114, with transfe~ operations occurring within an-exhausted, walk-in fume hood/enclost1re, as described in Section 3.0. • Control Area 2: Use of Class I, II & Ill-A Liquids within exhat1sted laboratory fume hoods, exhausted hoodi:;lenclosures, under exhausted-hoods or in closed equipment/systems in BSL-2 LabslRooms L 115 & L 1 f6 and Open Lab/Room L 107, as described in Section 3,0. • Explosion Control: Not.applicable to Isis operations for the following reasons: • No use of Class I Liquids in amounts >Exempt Amounts. • No explosive vapor-air mixtures under normal operating conditions. • Use conditions will be provided with mechanical exhaust ventilation such that flammable vapor-air mixtures will be at <!=25% LFL. • Application & Alternate Method ofCompllance: • Either general/area exhaust ventilation or local exhaust ventilation required in roomslareas were Class I Flammable, Class II Combustible or Class Ill-A Combustible Liquids are used' In a "use-open" condition, unless It can be demonstrated that there will be no flammaf?le vapor-air concentrations. • Use of local exhaust ventilation is considered to be an alternate to general/area· exhaust ventilation and requires specific acceptancelapproval of the Building Official. -. • Local Exhaust Ventliatlon: Same as Isis conditions, provided tile ~uilding Official accepts-local exhaust ventilation. • Generali Area Exhaust Ventilation: The following requirements will apply if local exhaust ventilation is not accepted by the Building Official: • Mechanical system. • 6 air changes per hour. • Exhaust taken from a pint at or near [within 12'1 of the lowest point of the roomlarea. • System designed and installed as Class 1 Product Conveying Exhaust Duct System -see Item 7. + UBC/CBC 1202.2.1 + UBC/CBC 104.2.8 + UBC/CBC 1202.2.2 t UFC/CFC 207 + UFC/CFC 7902.1.5 + UFC/CFC 8003.1.4 +UMC402 +UMC502 +UMC505 +UMC506. +UMC609 · • Attachment 2 't"Erlksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page 16 o~ 51 ---tall ~ '~21111111~11111~----~:::~:o-· .. _, __ j -~-: -~ ". '''l; llliil1 -· .. ': _______ _ . ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS-IBIS LAB ·BUILD-OUT 'hJll~~JJ.~i~fJilS:J'Jia6:ili~ci-al.$·, 0.Qildltloi:'i$ii! ;~:;~.;-_ \'.:~'-I ·~;;~'!o: ·.': -~ii .:'Co.di:Requlr.ema),ts' & .Concll~lons 6. Exhaust Ventilation Systems & Explosion Control - Class I & Ill-A Liquids -Control Areas 1 &2 [contln11ed] • Local Exh~ust Ventilation Systems -Alternate Method of Compliance: • Control Area 1 -Proposed Exhaust Ventilation System Conditions: • Type of System: Local exhaust ventilation inside an exhausted, walk-in fume/hood enclosure, with the system designed to capture and exhaust Flammable Liquids I and Combustible Liquids II vapors within the enclosure, as described in Section 3.0. • Location: Room L 114 NOTE: The exhausted, walk-in fume hood will have >/=1,000 cfm general area exhaust ventilation within the enclosure, preventing vapors from-exiting the enclosure into the room in which the-enciosure is located. • Control Area.2 -Proposed Exhaust Ventilation System Conditions: • Type of Systems: Local exhaust ventilation to capture and exhaust Flammable Liquids I and Combustible Liquids II & Ill-A v~pors at their.points of generation, as described in Section 3.0. • Locations: • BSl--2 Labs-Rooms l115 & L116 • Open Lab -Ro(?m L 107 • • Nonflammable Vapor Exhaust Conditions.-Class I Flammable Liquids: • See Section 3.0 and Attachment 2. • Nonflammable vapor-air mixtures and exhaust conditions can be maintained,!! the exhaust ventilation rates/conditions indicated in Attachment 2 and below tor·nonflammable vapor-air mixtures are provided. [Also, see Code Requirements & Conditions.] • Control Area 1: • </=25% LEULFL: 323.9177 cfm • </=10% LEULFL: 809.7943 cfm • Control Area 2: • </=25% LEULFL: 479.8011 cfm • </=10% LEULFL: 809.7943 cfm • Local Exhaust Ventilation Systems: • Type of System: Mechanical system, designed and installed as Class 1 Product Conveying Exhaust Duct System -see Item 7. · • Conveying Velocities: Conveying velocities within exhausted enclosures/hood·or under/in exhausted hoods to be not less than following for the conditions indicated: • <1=25% LEULFL Flammable Vapor-Air Mixture: ,. • Control Area 1: 323.9177 cfm, as indicated in Attachment 2. • Control Area 2: 479.8011 cfm, as indicated in Attachment 2. •· Minimum required In work areas. • Minimum required for exhaust ducts to extend through other areas. _ • <1=10% LEULFL Flammable Vapor-Air Mixture: • Control Area 1: 809.7943 cfm, as inicated in Attachment 2. • Control Area 2: 809. 7943 cfm, as indicated in Attachment"2. . • Minimum requir~d for unprotected exhaust ducts. -[i.e.: no.fire sprinklers in exhaust duels]. • Operation: During.such times as Class I, II or Ill-A Liquids are used/transferred. • Mal,<e-Up Air: Electrically interlocked with associated exhaust system(s)to insure sufficient supply of make- up air for exhaust systems. • Exhaust Air: ' No recirculation of exhaust air unless contaminants have been removed and flammable . . vapor-air concentrations are </=10% LEULFL. • Power Supply: Primary building power - emergency/standby power not required. -t UBC/CBC 104.2.8 . t UBC/CBC 1202.2.2 t UFC/CFC 207 t UFC/CFC 7902.1.5 + UFC/CFC 8003.1.4 tl)MC402 tUMC502 tUMC505 tUMC506 +UMC609 • Attachment 2 'YErlksen-Rattan Associates Inc. 4719 Palm Aven6e, La Mesa CA 91941 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions-12/14/01 [Rev. 2] -Page 17 of_ 51 - .. _, -~-dal·rr ii,:,;;.!:_ ~:-,:···-·· .-... · ···-., {£ ·~~---,_, -~l ¥~d ., ... ,_. __ _ ;,.J _; 1 ---··-'"··-ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES· ANALYSIS • -IBIS LAB BUILD-OUT 7. Class 1 Product Conveying Exhaust Duct System - Class I, II & Ill-A Liquids -Control Areas 1 &2 [continued on next.page] • Application -Control Areas 1 & 2: • An exhaust duct system complying with the requirements for a Class 1 product conveying exhaust duct system will be provided for exhausted laboratory .fume hoods, exhausted enclosures/hoods . and exhausted hoods in w!lich Class I Flammable or Class II or Ill-A Combustible Liquids will be used or transferred in an open system environment. . • See Section 3.0 for locations & Isis conditions. +General: • System designed & installed to ·control, capture & remove emissions generated from products used/handled. • Emissions confined to the area in which they i;ire generated by air currents, hoods or enclosures and exha1,1sted by a duct system to a safe location or treated by removing contaminants. • Exhaust ductswill not to extend into/through ducts& plenums. + Incompatible Vapors: There will be no incompatible vapor-conditions exhausted through the system based. on the following operational conditions: • No incompatible Class I, II or Ill-A Liquid vapors. •. No exhaust of incompatible materials at the same time through the same exhaust duct.system. · • Elevated Temperatures: Not applicable to Isis conditions --no elevated temperature exhaust air. • Explosion Venting: Not applicable to Isis conditions - -no explosive vapor/air co11centrations in exhaust ducts . • Fire Protection In ·Exhaust Ducts: • See Section 3.0 and Attachment 2. • Fire protection in exhaust ducts not required !f flammable-vapor air concentrations are maintained @ </=10% LFL. • Reclrculatlon: Contaminated air will not be recirculated to occupied areas unless contaminants have been removed. · TErlksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 · '<L~ \?/cod~Jtequitamarit• i;(:.~rid1t10 · · . + Class 1 Product Conveying Exhaust Duct System: • Ducts conveying nonabrasives, such as smoke, spray, mists, fogs, noncorrosive fumes·& gases, light fine dusts or powders. • Includes hoods/em,losures connected to the system. • Hoods/Enclosures: • Sheet metal/steel -->/=0.033 inch [20 gage] base metal thickness, or·other approved materials. • Approved nonmetallic hoods/enclosures can be used for nonflammable materials. • Also, See Items 9 & 26. +·Recirculation of Exhaust Air: No recirculation of contaminated air to occupied areas unless . contaminants have been removed. • Minimum Velocities & Circulation: • Contaminated captured by an air stream at the area where emissions are generated and conveyed into a product-conveying duct system. • Within work areas, vapors from Class I liquids diluted to </=25% of their LEULFL with air that-does not contain other contaminants. • Vapors generated from Class I Liquids to be diluted </=10% of their LEULFL for application of nonfl~mmabie vapor exhaust conditions [i.e.: no fire protection in exhaust ducts]. • Makeup Air: • Makeup air provided to replenish -air e?(hausted by the exhaust system. • Makeup air electrically interlocked with exhaust systems. • Makeup air intakes located so as to avoid recirculation of contaminated air within enclosures. • Power Supply: • Interlocked so that improper functioning of the collection system will shut down the equipment it serves. • Primary power -emergency/standby power not required. t UBC/CBC 713.10 + UBC/CBC 713.11 + UBC/CBC 1202.2.3 + UMC/CMC 402.4 + UMC/CMC 502 t UMC/CMC 505 t UMC/CM,C 506 + UMC/CMC 609 . + UFC/CFC 7902.5.11.4 t UFC/CFC 7903.2.3.5.3 + UFC/CFC 8003.1.4 + UFC/CFC 8003.3.1.3 +NFPA91 Technlcal Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2)-Page 18 of 51 - ···. ,: .. _ ....... . --- . .,-i';;·-1\';.'!_t,<J_ ''"'·'·--·· ---· 1,--··· -·-?' 1111111· '" : ' ~ ~ ~ Wu~ .. ...:::.wAtdllllllllll~-: ...... .J _..:._..,:~ !:'..r.cJ ~ .! .. -'.-:~-·-·--ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA COOES ANALYSIS -IBIS LAB BUll-D-OUT 7. Class 1 Conveying Exhaust Duct System --Class I, II & Ill-A Liquids - Control Areas 1 & 2 [continued] [continued on next page] [See previous page.] + Exhaust Ducts: • Through Building: • General: Cannot extend into through ducts/plenums not associated with the Class 1 exhaust duct system. . • Flammable Vapors >25% LFL: Extend directly to the exterior of the building wit~out entering other spaces. • Construc;tlon: • Sheet metal/steel or ottler materials approved/listed for use with flammable/combustible liquids. • Flexible metallic duct may be-used for connecting ductwork to equipment. • Approved nonmetallic hoods/ducts allowed to be used for nonflammable corrosive vapors. • Metal·hoods/ducts used for exhaust of corrosives & flammable/combustible liquids to be protected with corrosion-resistant material. • Thickness: Depends on pressure, type & size of duct -refer to UMC/CMC Tablei; 5-8 & 6-A. • Fittings: • >1=2 gages thicker than thickness required for straight runs. • Branches to connect to main duct(s) at the large ehd of transitions at >45o angle. • Cleanouts -Corrosive Vapors & Vapors with Particulate: Accesslbie cleanouts at 1 O' intervals and at changes in direction; . t UBC/CBC 713.10 t UBC/CBC 713.11 t UBCICBC 1202.2.3 t UMC/CMC 402.4 t UMC/CMC 502 t UMC/CMC 505 t UMCICMC 506 t UMC/CMC 609 t UFCICFC 7902.5.11.4 t UFC/CFC 7903.2.3.5.3 t UFC/CFC 8003.1.4 t UFCICFC 8003.3.1.3 . tNFPA91 TE;riksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12114/01 (Rev. 2] -Page 19 o~ 51 - _, ·--t-r-!Y;~ 1111!!!!!!!!1!! " ~ i?.i"fo-·"'-·"G' ~~~ ,.,, .... -.. -· .......... , .... ,, --,-~, ---, _ ... , ~~..:.:.: ., _ _,..,.,.,.. --.____,.,..; -~.:,,,:Ji • .J,J ~.: --J -···---·-·· ··-.. ,,-IS~S PHARMACEUTl'CALS. -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA-CODES ANALYSIS -IBIS LAB BUILD~OUT YU, .. :.·d~f;le.'.b~Ha1ttatIJ1~;~;11J1~'J!z'.;~lil~1Pa.tt"·,-, 7. ClasJ 1 Product Conveying Exhaust Duct System - Class I, II & m~A Llqui~s -Control Areas 1 &2 (continued] [continued on next page] [See previous page.] 'Y-Eriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 + Exhaust Ducts -continued: •· Fire Protection: • Sprinklers or o~her fire-protection devices to be Installed in ducts having a cross-sectional dimension >10" when the duct conveys flammable vapors or flammable gases. [Flammable vapors are the concentration of flammable constituents >/=10% of the lower flamrnability limit (LFL).] • Sprinklers, when required to be provided, to be installed as follows: • Horizontal Ducts: 12' intervals and at changes in direction. • Vertiqal Runs: Top and at alternate .floor levels. • See Item 20 for fire sprinkler design conditions. • Access Openings for Sprinklers: Access openings provided for access to sprinklers located in ducts. • Access Openings for Equipment: Access openings· provided for equipment located in ducts that requires servicing. • Supports: '!' </=8" Ducts: </=12' intervals. • >8" Ducts: </=20' intervals. • Design: Assume 50% of duct is fun· of the vapors being. conveyed. _ • Protection from Physical Damage: Protected by guards when Installed in locations where they may be subject physical damage, · +UBCICBC 713.10 + UBCICBC 713.11 + UBCICBC 1202.2.3 + UMC/CMC 402.4 +UMC/CMC 502 + UMC/CMC 505 + UMC/CMC 506 + UMC/CMC 609 , + UFC/CFC 7902.5.11.4 + UFC/CFC 7903.2.3.5.3 · + UFC/CFC 8003.1.4 + UFC/CFC 8003.3.1.3 +NFPA91 Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12114101 [Rev. 2) -Page 20 of 51 - -;; --r--!;£:-f!f·:-k,Xfil-~ i. 411111111111111~~ W--;·,:7;_,,.---·-·· ,· :-··:--· ·':" -·-, ~~-',r;.;.~~ ...... ,.--.: J •• .,...~ ,;.,.J _! .. , ----~--ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UN~FORM/CALlfORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT -~;;•).:','~~-... ~,,. °"'~UJt1·.··1J£." ~,-_,= .... r•f.;l'{(. ·,_,;;'~""0"1··., .. '*'ii.ii'' .,. Ja:"'~----t,lil. .. '.". Ji' ·:,j'<··· • =. :.;jlt .. ,, .. 0"" __ -_· '·;;c.:, ·.·•. ·,--_ •. F';.:-:-. ·.•.• ''-'""';-C'" .... · .,·:.._ ,,,, "" -,"···-· . ·t-".c--_, __ & __ ·. ci:.. ':;,-i·t-, ~-' ... ",,,_.,,1·c:,.y$).~9.,v,Onu. •~•HJ,:,;.i:: 1.\:,tw:,::;.~-!f:~,,1-. ... ;~.! mta..C.fU. __ .,.a ~g,lJ~ _ons~=:·,r-::,":::-:-_;c,·~1.~L:•~:,:, g,u~t_qt,1 ,.81l181'l_S .... _.unu OhS · 7, Class 1 Product Conveying Exhaust Duct System - Class I, II & Ill-A Liquids -Control Areas 1 &2 (continued] [See previous page.] • Exhaust Ducts -continued: • Exhaust Outlet ,:ennlnatlon: • Nonflamma!:>le Vapor Exhaust: • >/=10' from the following conditions: • Property lines • Openings into building which are in direction of · exhaust discharge. • Above grade. • >/=3' from exterior walls & roofs. • Flammable Vapor Exhaust: • >/=30' from the following conditions: • Property lines. . • Combustiblewalls or openings into building located in the <;lirection of exhaust discharge • • >/=10' ~bove adjoining grade. • >/=6' from exterior walls or roofs. • Clearance-from Combustjble Construction: >/=18" o·r protected with approved construction [i.e.: insulation]. • Elevated Temperatures~ Same as Isis conditions -- not applicable. • Explosion Venting: Same.as Same as Isis conditions -not applicable. • Dampers: • Fire/Smoke Dampers: • Not allowed, except for the following conditions: • Through fire walls/floors. • Collection system at end of system protected by fire sprinkler system. • b,u'ct system protected by fire sprinkler system, •Tobe accessible for servicing & inspection. NOTE: Supply air to be interlocked with exhaust air to Insure adequate supply/make-up air for exhaust system to operate properly. • Volume/Balancing Dampers: • Allowed only for weather or back-draft protection, located only on clean-air side of filtration system. • Balancing devices secured to prevent inadvertent adjustment or loss of transport velocltv. · +UBC/CBC713.10 + UBC/CBC 713.11 tUBC/CBC 1202.2.3 + UMC/CMC 402.4 + UMC/CMC 502 + UMC/CMC 505 + UMC/CMC 506 + UMC/CMC 609 + UFC/CFC 7902.5.11.4 + UFC/CFC 7903.2:3.5.3 • • UFC/CFC 8003.1.4 + UFC/CFC 8003.3.1.3 +NFPA.91 TEriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page 21 of 51 - .. -. -lalll' "'-~- ..,~.,,.,..,,., _,,,_.---. ···111111. ---.. ---:1 --' tli_ ·_ ~--~:~ '·.tf.-.:c. --~_j ... ~.,..: ... -hi.~ ~ J -; --~-----, ... ,-ISIS PHARMACEUTICALS -·1891 Rutherford~ Carlsbad CA - UNIFOR'1,1/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT 8. Class 5 Product Conveying Exhaust Duct Systems - Corrosives - Exhausted Hoods/ Enclosures & Gas Cabinets.! Control Are~2 9. Exhausted Fume Hoods/Exhausted Enclosures & Gas Cabinets · [continued on next page] NOTE: Owner furnished/ Installed equipment not speclflcally related to building construction conditions. + Application : • Corrosive liquids may be used in Control Area 2 at locations where local exhaust ventilation is provided [i.e.: under exhausted hoods, In exhausted enclosur~s. within lab exhausted hoods]. • Phosgene, a Highly Toxic & Corrosive ~mpressed gas, will _be located in an exhausted gas cabinet or exhausted enclosure, with the exhaust directed through a Class 5 product conveying exhaust duct system: NOTE: ·Exhaust ventilation for liquids other than Class I, II & Ill-A is not specifically required 6ecause materials will be used in amounts <Exempt Amounts. • Exhausted laboratory fume hoods anc_i exhausted enclosures will comply with applic;able Code requirements. ' • Owner furnlshedfinstalled equipment. YErlksen-Rattan Associates inc. 4719 Palm Avenue, La Mesa CA 91941 + Class ~ Product Conveying Exhaust Systems: • Ducts conveying corrosives,_ such as acid vapors. • Includes hoodslenclosures connected to the.system. + Requirements: Same a_s Class_ 1 Systems, except as follows: • Nonmetalllc Hoods & Duct Systems: Approved nonmetallic hoods and doct systems may be used when corrosive vapors ~re nonflammable. • Metal Hoods: • Protected with corrosion-resistant material(s). • Rounded edges. · • Gas Cabinets -Highly ToxlcfCorroslve Gases: Also see Items 9 & 26. • Exhausted Enclosure -Hlghly ToxlcfCorroslve Gases: Also see Items 9 & 26. + Duct Linings': Metal ducts that are not corrosion-resistant to be protected with approved corrosion-resistant material. +General: See items 6-8 andAttachment 2. • Exhausted Hoods: • Construction: • Compatible with materials located-therein. • Listed or approved. • For Highly Toxic Gases, also see lt1;1m 26. • Ventilation: • Maintain negative pressure in enclosurefunder hood with respect to room, with air currents created by exhaust system to capture contaminants and transport them directly tolthrough an exhaust duct syst1;1m -see lt1;1m 8. • Other than Highly Toxic Gases: • >/=100 fpm average ventilation velocity at faceffront opening. • >/=70 fpm minimum ventilation velocity at any point of face/front opening. • Toxic Gases: • >1=200 fpm average ventilation velocity at facelfront opening. • >1=150 fpm ventilation velocity at any point of facet front opening. • Electrical: See Item 10 for electrically classified locations. t UBCICBC 713.10 + UBCICBC 713.~1 • UBCICBC 1202.2.3 + UMCICMC 402.4 • UMCICMC 502 • UMCICMC 505 t·UMCICMC 506 , + UMC/CMC 609 + UFCICFC 7902.5.11.4 + UFCICFC 7903.2.3.5.3 • UFCICFC 8003.1.4 • UFCICFC8003.3.1.3 +NFPA91 • UFCICFC 206 t lJFC/CFC 8001.10.4 t UFC/CFC 8003.3.1.3 • UMCICMC 505.7 Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12114/01 [Rev. 2] -Page 22 of.51 - ~}(.\ .. ~-vt·~ ,-r:~::w~~~ ···:--:~:1 W~::2 ma:] ISIS PHARMACEUTICALS -1891 Ruthe~ord, Carlsbad CA UNJFO~M/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT --r·-· ~lfiillilliila w,,·-· Ci. ~~ -~ lllll -=-·:...-~---- \.-;;:,/:pq~lt~C.~ndi.t10:1:t~t:B]0ffl~~1~is1s,eharmi1:eutl~l•:-~tifid1iIBJJ!!~/,:t: _.,;_ '-~11~,-,-~-·:·>.f:.~ cpct_e' Riqu1r~i:rl1n~-.& g()11cii~1ons : . :-· · · 9. Exhausted Fum-, Hoods/Exhausted Enclosures & Gas Cabinets [continued] NOTE: Owner furnished/- Installed equipment not speclflcally related to building construction conditions. 10. Electrically Classified Areas - Class I Fla"'mable Liquids in Use & Transfer and Flammable Gases , [continued on next page] [See previous page.) + Control Area 1: • Class I Flammable Liquids: • Tenant Improvement Locations: Chemical Wast~ Storage-Rooms L114 & L117. • Conditions: •· L114: • Storage and liquid transfe~ operations. • Exhaust ventilation in exhausted, walk-in fume hood/enclosure. • General area ventilation in room. • No pits/recessed floor areas. • L117: • Storage only -·no use/transfer operations. • General area ventilation. • No pits/recessed floor areas. • Flammable Gases: None. TEriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 + Exhausted Enclosures: • Construction: •· Compatible with materials located therein. • -Noncombustible when used to increase exempt amounts. • Ventilation: Same as exhausted ·hoods. • Electrical: See Item 10 for electrically ~lassifled locations. • Highly Toxic Gases: Also see Item 26. . + Gas Cabinets/Highly Toxic Gases: See .Item 26. + Application: • "Classified electrical8 equipment, wiring & devices are required in the locations des~ribe<;I below and on the following page, if such equipment, wiring & devices are located within the boundaries of the areas indicated. • If the conditions described on the following page do not exist, "classified e_lectrical" is not required to be provided +Class 1, Division 1-Group P Electrical Locations- Flammable Liquids: · • Open Ends of Vents: Within 3' of.open end(s) of vent(s), extending in all directions. . • Vents & Fill Opening~: Within 3' of vent(s) and fill openings(s), extending in all directions. · • Equipment Where Flamm.able Vapor/Air Mixtures Could Exit Under·Normal Operations: Area within 5' of any edge of such equipment, extending in all directions. • UFC/CFC 206 • UFC/CFC 8001.10.4 • UFC/CFC 8003.3.1.3 • UMC/CMC 505.7 • UFCfCFC 7901.4 • UFC/CFC 7901.10 • UFC/CFC Table 7901.4-A • UFC/CFC 7903.2.2 • UFC/CFC 8001.9 +NEC 500-3 +NFPA • 30 • 345 • 491 • 497 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2] -Page 23 o~ 51 _,1 --lJIII ~ TV, L;' __ "_ . .. ·,--· ·, ~ ' • I ~ ~-. --=..-... ~ -,..,,_,.,.~h------.. -J ~;~~ __ '. __ ,; -----~--ISi$ PHA~MACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT -;~/t;:icqct•1.P~ri.d1.t1_a.11·,;~)?i~:Ol~ti1¼"1W~UU~JeharMil{eutt$Cptt.a1t1ons:r,::~·:)~~-:~i:::.:-::::~cott.e·RequiFemarits·lJ:;ond1t1ons. 10. Electrically · Classified Areas - Class I Flammable Liquids in Use & Transfer and Flammable Gases (continued] (continued on next page] • Control Area 2: • Class I Flammable Liquids: • Tenant Improvement Locations: • BSL-2 Labs -Rooms L 115 & L 1 t6 • Open Lal> -Room L 107 • Conditions: • Storage. • Open & closed systems use environments with local mechanical exhaust ventilation. • G~neral area ventilation. • No pits/recessed floor are-as. • See Section 3.0 • Flarrimable Gases: • Tenant Improvement Locations: • BSL-2 Labs.,.. Rooms L 115 & L116 • Open Lab-Room 1.,.107 • Conditions: • Closed system,use operations in mechanically ventilated areas. • General area ventilation. • Class 1, Division 2-Group D Ele~trtcal Locations - Flammable Liquids: • Open Ends of Vents: Area between 3' & 5' of open end(s) of vent(s), extending in all direc.tions. • Vents & Fill Openings: Area b~tween 3' & 5' from vent(s) & fill opening(s), extending in all directions. Also, up to 18" above floor within a horizontal radius of 10' from such openings. • Pumps, Bleeders, Withdrawal Fittings, Meters,. Etc.: Within 5' of any edge of pumps, bleeders, withdrawal fittings, rrieters, etc., extending in ali directions. Also, lip 3' above floor level & within 25' horizontally from any edge of such devices. • Equlpn,ent Where Flammable VapQr/Alr Mixtures Could Exit Under Normal Operations: · . • Area between 5' & 8' of any edge of such equipment, extending inall directions. • Also, area up to 3' abov~ floor within 5'-25' t1orizontally from any edge of such equipment. • Areas Outside of Openings· In Electrically Classified Area within 50' Horizontally of Flammable Vapor Source: Area within 1 O' horizontally of openir'lg(s), up to 3' above the floor for a 5' radius. · · • Ciass 1, Division 1-Group B Electrical Locations - Flammable Gases: • Open Ends of Vents: Within~· of open end(s) of vent(s), extending in all directions . • Connections, Vents & FIii Qpenlngs: Within 3' of .connection(s), vent(s) and fill openings(s), extending in all directions. • Equipment Where Flammable Vapor/Air Mixtures Could Exit Under Normal Operations: Area within 3' of any edge of such equipment, extending in all directions. + UFC/CFC 7901.4 • UFC/CFC 7901.10 • UFC/CFC Table 7901.4-A • UFC/CFC 7903.2.2 + UFC/CFC ~001.9 +NEC500-3 +NFPA • 30 • 325 • 491 • 497 'f Eriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2] -Page 24 of 51 - ·.: -----··; r···-·-------------· ... ~--·r ~--· f)"}S"_!i··· 1'/Pft,·· :--.-....... ··-· ---, . ,-, ... -··; _, -· ·---• -: " • '•~ ~-~ ~. 1/"@':-~9 is.e:,,~.1-IM-~ ... -,:;.-;J.d _ ~".J ' ..J ; I • ' <-, ISIS PHARMACEUTICALS -1891 Rutllerford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANAL, YSIS -IBIS LAB BUILD-OUT . .,;.'i'l\>Godi~Ctsn'·d1Ua-rt.~~~~1~,:.r;,.::~;;;~~~iii'.cfs~ Is' .:,.1.:•a··~-·;c, '·u· ti·_·,·· ts· ·:c· ~·n""'"'lt' 10·-'•!.;.' ·./:, :~: . .' · . :. ;:, F · -~_. '? /_'.:';.~;~!=c· :.i.d' '-Re"gru· 1·-'~:,. •i;;.,&-c,,.-· ttltl ns. · :: ... •" . -· 'c',,i.-.C-. • ........ , ..... , .... --""'"ti" ,_.,;,."_.,;i.,,;l ..... _,r.;,, ,u., .• ac:, _ca_ .0 u n;!! .. ,_.,,....... . ,_ ....... ,.•., u_ e. . . .r~ .• en,... ... n O . . ·. •. 10. Electrically Classified Areas - Class I Flammable Liquids in Use & Transfer and Flammable Gases [co~tlnued] 11. Egress System [co.ntlnued on next page) [See previous page.] · Review of egress system.is outi;ide the scope of this report-Code-Requirements & Conditions provided as "information only": • Class I, Division 2-Group .B Electrical Locations -· Flammaple Gases: • Open Ends of Vents: Area between 3' & 25' of open end(s) of vent(s), extending in all directions. • Connections, Vents & Fill Openings: • Area between 3' & 25' from connections, vent(s)-& fill opening(s), extendlf'1g in all directions and to the . floor. • Also, up to 25' above floor level & within 25' horizontally from any edge of such devices. • Equipment Where Flammable Vapor/Air Mixtures Could Exit Under Normal Operations: • Area -between 3' & 25' of any edge of such equipment, extending in all directions. • Also,.area up to 25' above floor within >3'-25' horizontally from any edge of such equipment. • Areas Outside of l,Jnprotected Openings In Electrically Classified Area wlthl!'l 50' Horizontally of·Flammable Gas Source: Area-within 10' horizontally of opening(s), up to 25' above the floor for a 5i radius • +·Maximum Travel Distance to 1 Exit-B & S Occupancy Conditions: • No 1-Hour Exit Corridors; 250;. . • With 1-Hour Exit Corridor: +100', provided that the last portion of exit access leading to the exit occurs within a corridor, with the length of the corridor not less than the amount of increase taken. • Conditions Where >1 Exit Required -B & S Occupancy Conditions: • Occupancy Conditions: * B: • Occupant Load: >/=30. • Occupant Load Calc1.1lation: 100 sf/person. • S1: • Occupant Load: >1=30. • Occupant Load Calculation: 300 sf/person. • Travel Distance Conditions/Limitations: See above . · • UFC/CFC 7901.4 + UFC/CFC 7901.10 + UFC/CFC Table 7901.4-A . • UFC/CFC 7903.2.2 • UFCICFC 8001.9 +NEC500-3 +NFPA • 30 • 325 • 491 • 497 • UBC/CBC 304.4 • UBC/CBC 311.4 + UBC/CBC 713 +UBC/CBC 1003-1007 • UBC/GBC Table 10-A t UBC Std 7-2 t UFC/CFC 1201-1213 'YEriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 (Rev. 2) -Page 25 o_f 51 IIIIE --- r-,,,.,,_ r71;-~ ~ ~ ~,:;g>i_,,§9; __ ·'"• t:,:.,;;, ... : .. : ...... _-~.;-".,,.:;; ..,,a-·1 _, ..i.J --' . ·'---~-~·--ISIS PHARMACEUTICALS -t891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT .11. Egress System (continued] . [c_ontlnued on next page) -. . ' . Review of egress system. is outside the scope of this · report -Code Requirements & Conditions provided as· "informat.ion only". • Separation of Exits -2 Exits Required: Placed a distance apart >/=1/2 overall diagonal dimension of the area served, measured in a straight line between the center of , exits or exit-access doorways. . +Means of Egress Doors orGates-B & S Occupancy CondltlQns: • Number: • Minimum: 1 from all rooms/areas. • >1: See previous page -conditions where >1 exit required. • Swing: Direction of exit travel for the following conditions for >/=50 calculated occupant load. • Width -Single Leaf: >/=3' & </=4'. • Haight: >/=6'8". • Locking/Latching Hardware: • Openable without use of a key or any special knowledge or effort. · • No manually operated edge-or surface-mounted flush bolts. • Travel through Intervening· ~ooms: .• Access to exits to be directly from tJ,e space under consideration to an exit or to a corridor that provides direct ·access to an-(!xit. • Exit access-not be Interrupted by interYening rooms except as follows: • Foyers, lobbies, reception rooms, exit corridors. • Only 1 Exit Required: OK through adjoining/intervening room, -which in tum provides direct access to an exit or to a corridor that provides direct access to-an exit, when accumulative occupant load is <30. • Room(s) with cumulative occupant of <10 . +Aisles: • General: Provided from all occupied areas containing seats, tables, furnishings, displays, equipment, storage, etc. • Non-Public Accessible -Employees Only: >/=24" wide. • Public Accessible: • Obstructions on Only 1 Side: >/=36" wide. • Obstructions on Both Sides: >/=44" wide. • Dead-Ends: </=20' + UBC/CBC 304.4' + UBC/CBC 311.4 + UBC/CBC713 · + UBC/CBC 1003-1007 + UBC/CBC Table ·10-A + UBC Std 7-2 + UFC/CFC 1201-1213 TEriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12114/01 [Rev. 2] -Page 26 o~ 51 - ·<?~-~- ... i'i t'·;;--~,_..:..:;-~~i -~,,;; aa1J ISIS PHARMACEUTICALS -1-891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBiS LAB BUILD-OUT --£11111 w. . 1;.:~;,.11:: --~~-IIIIJ -j -· ·: ______ .. ::• '·"- . 11. Egress ·system [continued] [continued on ne~t page] Review of egress system is outside the scope of this . report -Code Requirements & Conditions provided as "information only". · 'fEriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 . +Hallways: • General: • Allowec! to be used as an exit-access.component unless specifically prohibited. • Considered as .intervening rooms. • Dead-Ends: </=20'. • Width: • <50 OccupanfLoad: 36" • >/=50' Occupant Load: >/=44" • Obstructions: Unobstructed, except for the following conditions: • Doors: • Any Position: </=1/2 required hallway width. • Fully. Opened: <l=r. • Handrails: </=7". • Trim: </=1.5" on each side of hallway. • Construction: Noncombustible. • Openings: No restriction/limitation. + Exit Corridors: • General: • Combustible ornoncombustible construction. • 1-hour fire-resistive construction when conditions do not allow the corridor to be addressed as a hallway. [NOTE: A hallway is ~ddressed as intervening room, whereas an exit corridor is not addressed as an intervening room.] • Dead-Ends: c:./=20.'. + UBC/CBC 304.4 +UBC/CBC 311.4 + UBC/CBC 713 + llBC/CBC 1003-1007 . + UBC/CBC Table 10-A + \)BC Sid 7-2 + UFC/CFC 1201-1213 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page 27 of 51 - llllt --t-~,--~-~-~ <;;;~:11111.,_-'.J ' ~:-,:,,~ -~ ~ .. -, __ ·---,., __ ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA · UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT 11. Egre$S System [continued] [cqntlnued on next page] Review of egress system is outside the scope of this· report -Code Requirements & Conditions provided as "information only". · 'f'Eriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 • Exit Corridors •-continued: • Construction: • General: Fully enclosed by walls, a floor, a ceiling and permitted protected openings. • Walls: Walls to extend vertically to a floor-ceiling or roof-celling as follows: • 1-hour fire-resistive constrtuction. • Corridor-side ofwall(s) to terminate atthe corridor · ceiling membrante approved for 1~hour fire-resistive floor-ceiling or roof-ceiling assembly to include suspended ceilings, dropped.ceilings &.lay-in roof- ceiling panels, which are a portion of the fire-resistive assembly. • Room-side of wall(s) to terminate the underside of.a floor or .roof constructed of materials appraoved for 1- hour fire-resistive floor-celling or roof-ceiling assembly, except for the following condition: • Where the corridor-is an element of a 1-hour fire- resistive floor-ceiling or roof,ceiling assembly at_ t.he entire story, both ~ides of corridor walls may terminate at the ceiling membrane. • Celllngs: As indicated above and the following: • Qorridor ceiling(s) can be constructed-of materials . approved for a fire-resistive. wall assembly; When this method is used, the following conditions shall met: • Corridor-side fire-resistive membane of the corridor wall-to terminate at the lower ceiling membrane; and • The room-side fire-resistivl:l membrane of the corridor wall to terminate at the upper celling membrane. • Corridor c;eilings· of noncombustible construction allowed below the fire-resistive ceiling membrane. t UBC/CBC 304.4 • UBC/CBC 311.4 + UBC/CBC 713 + UBC/CBC 1003-1007 t UBC/CBC Table 10-A t lJBC Std 7-2 • UFC/CFC 1201-1213 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2] -Page 28 of_ 51 - ! ! . r .. .-,.,~ ;r--·~ ,m--, r ,-,·-• ~--• . ., ~N, ry•• [[";fl . ~:~:-..-~~ ' •-. --~~-,,::; ., ••:; lllillJ -j ---111111 '-·- .... . ' ISIS. PHARMACEUTICALS ~ 1891 Ruthe_rford, Carl$bad CA . . UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT·_ 11-. Egress System '[continued] ... [continued on next page] Review of egress system is outside the scope-of-this · report -Code Requirements & Conditions provided as "information only". + Exit Corridors • continued: • Construction • continued: • Doors: • Type: 20-minute, tightfitting smoke-and <!raft-control assemblies, including frame. • Unprotected Openings: No unprotected openings -[i.e.: no louvers, mail slots or smilar openings]. • Closing: • Self-closing; or • Automatic-closing by actuation of a smoke detector, with hold-open devices releasing or closing the door in the event of a power failure at the hold-open-device. • Glazing: Lim.ited to </=100 square inches, with a minimum dimension of 4 inches. •Windows: • Fixed, non-openable. • Listed & labeled or marked for >/=3/4-hour fire protection rating, including frame. • Total area in a corridor limtied to 25% of the area of a ·common wall with any room. • Ducts: • Smoke Dampers: • Provided for perietratli;,ns of the fire-re.slstive consJruction, exceprfor steel·duct penetrations when ducts are >/=0.019" thickness arid have no openings serving the corridor.' • Dampers to close by actuation of a smoke detector. • Fire Dampers: · • Provided for penetrattons of the fire-resistive constructlon,-except for steel duct penetrations when ducts are >/=0.019" thlckness·and have no openings serving the corridor. • Dampers to close-by actuation of a heat actuating . device, with the heat actuating device operating as follows: . • Approximately 50oF above the normal temperature within the duct system, and • Not less than 160oF. • Access to Dampers: Dampers to be accessible for servicing & inspection. + UBC/CBC 304A + UBC/CBC 311 -4 + UBC/CBC 713 • UBC/CBC 1003-1007 + UBC/CBC Table 10-A + UBC Std 7-2 + UFC/CFC 1201-1213 TErlksen-Ratlan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page 29 of 51 - -~ -· -, ..... v.,;w ~y f."'-:·-· ........ --1 .. ---·;· 1 -·1 -! -------....a.::: ~ ~ • =--~-ilb:t,::....,,_~,.,_,..~_......,__n,..U ' r..~J J • _..J ~ ' "" J;~ ~ ISIS PHARMACEUTICALS -1891 Rutherford, Carls.bad CA UNIFORM/CALIFORNIA CODES _ANALYSIS -IBIS LAB BUILD-OUT 12.-Egress System, [continued] ·12. Liquid Transfer OperatlQns - Hazar(J Ranking 3 & 4 Liquids -Control Areas 1 & 2 [continued on next page] NOTE: Not speclflcally related to building construction conditions. Piping/tubing systems & . pump transfer systems, If any, wlll be submitted for separate plan ch!ck/permlt. ·Review of egress system is outside the scope of this report -Code Requirements & Conditions provided as "information only". + Individual C~mtalner Sizes: • Hazard Ranking 3 Liquids: </=5.3 gallons [</=20 liters]. • Hazard, Ranking 4 Liquids: <1.06-gallons [<4 !iters]. . • Maximum Transfer Amounts: • Class I Liquids: </=1.06 gallons [</=4 liters]. • Class II & Ill-A Liquids: </=5.3 gallons [</=20 liters] • other Haz~rd Ranking 3 Liquids: </=1.06 gallons [<4 liters]. . • other Hazard Ranking 4 Liquids: </=0.264 gallon [</=1 liter]. · t • Liquid Transfer/Dlsp~msing Methods: • Manual transfer/dispensing. • For Class I, II & Ill-A Liquids, transfer operations will occur with exhaustventilation, as described in Item 6 and Section 3.0. • No gravity transfer from vessels >20-liter capaci 'f'Eriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 + Exit Corridors -continued: • Width: • <50 Occupant Load: 36" • >/=50 Occupant Load: >/=44" • Obstructions: Unobstructed, except for the following conditions: • Doors: • Any Position: </=1/2 required hailway width. • Fully Opened: </=7". • Handrails: </::,.7". • Trim: </=1.5" on each side of corridor. • Storage/Usable Space Under Stairs: • Walls & soffits of the enclosed space to be protected on the enclosed side by 1-hour fire-resistive construction. • Construction to also comply with the requirements for 1- hour exit corridors where stairways are located within a 1- hour exit corridor system. + Class I, II & Ill-A Liquids: • Positive Displacement Pumps: • Provided with pressure relief discharging back to the vessel, pump suction or other approved. location; or • Interlocks provided, to-prevent overpressure. • Pressurized Systems: _ • Gases Used for Pressurization: Inert gases only -no air or oxygen. · • Control~: Pressure-relief devices to limit pressure to </=maximum working pressure of vessels and piping systems. • Class I, II & Ill-A Liquids: Transfer by any of the following methods: • </=20-liter [</=5.3-gallon] containers. • Safety cans. • Approved closed piping system. • Vessels by an approved pump taking suction through an opening in the top of the vessel. + UBC/CBC 304.4 t UBC/CBC 311.4 . t UBC/CBC 713 t UBC/CBC 100$1007 . t UBC/CBC Table 10-A t UBC Std 7-2 t UFC/CF.C 1201-1213 + UFC/CFC 7903.1.3 + UFC/GFC 8004.1.15 Technical Report -Hazardous Materials & Storage Operations Code Requlr~ments & Conditions -12/14/01 [Rev. 2] -Page 30 of 51 - .... ''· . ·~· ---i---r;; @.ff': ~ ~~~ '~ ~~:-r,;,.;--i:Q, .~ t;'.:,t'.:--,:._. '°"' 'IIIIL. 'I -· ,1 ~--r~ IIIIIIJ, ,....,. __ j. ~ •J,:,~J ~ ' -·-~-~--------ISi$ PHARMACEUTICALS·-· 1891-Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS .. IBIS LAB BUILD-OUT 12.. LiqL1id Transfer Operations - Hazard Ranking 3 & 4 Liquids -Control Areas 1 &2 [continued} NOTE: Not specifically related to building construction conditions. Piping/tubing systems & pump transfer systems, If · any, will be submitted for separate. plan check/permit. 13. Piping; Valves & Fittings- Compressed Gases . & Cryogenic Fluids -Control Area 2 [continued on next page) NOTE: Not specifically related to building construction conditions. Piping/tubing systems will be submitted for separate ·plan check/permit. • Prevention of Static Accumulations -Class I Flammable liquids: Bonding/grounding will be provided for Class I Flammable Liquid transfer systems/conditions to prevent static accumulations where diffe.rences-of potential could be created. Piping, valves & fittings for compressed gases & cry9genic fluids will comply with applicable Code requirements. ~ Eriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 • Gravity Transfer-Class 18, IC &,Ill-A Liquids - Vessels >20-Llter [>5.3-Gallon): Gravity transfer OK · under the following. conditions: • Approved self or automatic closing valve. • Spill' control & containment provided [as required for H Occupancy conditions -see Item 17]. • Class I Liquids -Prevention of Static Accumulations: Bonding/grounding provided for Class I Flammable Liquid transfer systems/conditions to prevent static accumulations where differences of potential could be created. . • Other Hazard Ran kl rig 3 & 4 Liquids: No specific Code requirements applicable to transfer/dispensing operations in Control Areas. •Compressed Gases: Also, see ltem,26. •Cryogenic Fluids: Also, see Item 16 •. • Design: Designed and f!:!bricated from Materials compatible with material to be contained. + Strength: Adequate strength and durability to withstand pressure, structural & seismic stress, and exposure to which subjected. • Standard: General ~mpliance witt, ANSI 831.3 • Low Metting Point Materials -Class I Fl~mmable, Class II· or Ill-A Combustible Liquids, Flammable Gases: If used, low melting point materials [i.e.: aluminum, copper, brass, nonmetallic Materials, nonductile Materials] to comply with the following conditions: • Suitably protected against fire exposure, • Located such that leakage resulting from failure will not present an exposure hazard. • Located such that leakage can be controlled by operation of accessible remotely located valve(s}. t UFC/CFC ?903,1.3 • UFC/CFC 8004,1.15 +UFC/CFC 74 +UFC/CFC75 + UFC/CFC 7901.11 + UFC/CFC 8001.16 + UFC/CFC 8001.4.3 +ANSIA13.1 +ANSI B31.3 Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page 31 of 51 - ----mllll OIIIIII """S"•·' --~ ~--;:,~.:..11111. ... -~---~-~; .. D IIIIIL: -,~ -·-----,,.-ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT l>•·d:;.-".-.•-·n··.a1f·(, ·.,,:!W:!.i,l"~t,•~;..,-.,; .. :-c•e~,...,~.,·"".'*'".·.a::. ·:!::··•.·.".· .. ·.• .. li,. l:.:,'•t(". J.l:. C .. ,.· .. d.1.tl '• .· .. , "·.'.·· .·,: .... '!'fflf .···,.~ .... --o•. tr">!k• ..... ,., •. , .•... .._ .. :..,. .• ~c ... ,d·· ·1··11. , .. • . . . . ~.\:I~. U 01,1:,-td,':: /.-.,_~~~.j:.·t·;;~-.t_1t_;.r,;;IJ_~l'Jtl8~~""" _J:,@ ~ __ !mS.: . .:_'•.:,1, ,· : .; _.:. :· : ;,,.; () .fJ.·-~8qU remeuut-Q. On OnS • 13. Piping, Valves & Fittings- Compressed Gases & Cryogenic Fluids -Control Area 2 [continued] [continued on next page] NOTE: Not speclflcally related to building construction conditions. Piping/tubing s~tems will be submitted for separate plan check/permit. Piping, valves & fittings for compressed gases & cryogenic fluids will comply with applicable Code requirements. • Locatlc;m Limitations -Corrosive or Toxic Liquids: Cannot be installed in the following indoor locations: • Within any portion of an exit corridor. • Within any portion of a means of egress required to.be enclosed in fire-resistive construction. • In conc~led spaces in or above areas not classified as H · Occupancies. +Valves: • General: • Piping system(s) to contain a sufficient number of manual control valves & check valves to operate system properly and to protect.the area under both normal & emergency conditions. • Piping in connection with pumps to contain sufficient number of valves to control liqt1id flow In normal operation and in the event of physical damage or fire exposure. • Emergency Shutoff Valves: • Required for Corrosive; Highly Toxic.& Toxic liquid supply piping/tubing in the following locations: At the .point of. use; and · At the tank or bulk source. • Identified.and location visible and indicated by a sign. • Backflow Prevenflon/Check Valves: Provided when backflow could create a hazardous condition or cause unauthorized discharge. • Drainage Control Valves: Manual drainage-control valves to be located remote from containment area/drainage·system such that they can be operated in a. fire condition. • Pipe Joints: • Liquid-tight. • Welded, flanged or threaded --welded required only when located in conc~aled spaces inside the building. • Nonmetallic joints to be approved. • Pipe joints dependent on friction·characteristics or resilience of combustible Materials for mechanical continuity or liquid tightne~~ of piping allowed only outside of building. +·UFC/CFC 74 +UFC/CFC75 + UFC/CFC 7901.11 • UFC/CFC 8001.16 + UFC/CFC 8001.4.3 +ANSI A13.1 +ANSI B31.3 TEriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page 32 of 51 - .. --Ellill .. ~~~'-: ._,-,_. ·,-·.·, ·<'J __ , _,, -.. --,_..,..,__._,.,_,,~_.,_ _...:; .-.td ..4,J '..,.! ,'~ I ~_, ' ._:-.,.~. ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFO.RM/CALIFORNIA CODES ANAL Y~IS • IBIS LAB· BUILD-OUT 13. Piping, Valves & Fittings- Compres!.ed Gases & Cryogenic Fluids -Control Area 2 [continued] NOTE: Not specifically · related to building construction conditions. Piping/tubing systems will be submitted for separate plan ch~k/permlt. Piping, valves & fittings for compressed gases & cryogenic fluids will comply with applicable Code requirements. TErlksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 • Pipe Bends: </=90o or at a. radius less than 5 diameters of the nominal trade size of tile pipe/tube [radius measured from inside edge of pipe/tube). • Testing: One [1] of the following, prior piping system being enclosed or placed in use -no leakage or permanent distortion for >'/=10 minutes: • Hydrostatically tested to >/=150% of maximum anticipated system pressure. • Pneumatically tested to >/=110% of maximum antipipated system pressure, but not less than 5 psig at high~t'point of the system. + Identification -Piping/Tubing: Piping/tubing Identified to Indicate material conveyed with directional arrows -per ANSI A13.1 --as follows: • Eaqh valve. • Each wall, floor, ceiling penetration. • Each change in-direction. • Every 20' or fraction thereof throughout piping runs. • Supports: Adequately supported & seismically braced; with bracing/support in accordance with the following: ;>.:":f1~Wi':\']le.fpilSlj </=1/2" 3/4"=1" >1=1-114" -Horizontal >/=1-1/4" -Vertical <1=6' </=10' · Every Floor Level tUFCICFC74 tUFCICFC75 t UFC/CFC 7901. 11 t UFC/CFC 8001.16 t UFCICFC 8001.4.3 tANSIA13.1 +ANSI B31.3 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12114/01 (Rev. 2} -Page 33 of 51 - 1 ., l 3 ~ j ~ j ·, i ~ i ' ·, J ! ! ¥. ~ -,. ~ } j ', ~ ~ i \'! ~ j ........ ,-: lllliiililiilci --. , __ . 'fl'.-iilliiliM W'--' ..... ~ ,., • .,.,, (;t,,· --··· ' '.,. .. ' 1 • ,-. -' -., _, ---~ ....aJ ; fLllllalll ~ ~tlllllllll ~:~~ ~~ .::..... .. h.. • __ .J t:: .. :ul ·,.J _: ,.,..:.J '....., ~-.----~ ,. -.... , ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CAL.lfORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT '· .' .:. ·:.,o.cfdjit®.6tt.1t@tf.!tWJ~ ·;,it~~J!:~!~ettfmticeu:t1~iJ,1¢q.hdltlc#1s:J:t;:-\~;: Ft· : ~i>, ·::, c~e .Rtqlilr..li.~ents: ~ co.nd1t1o_n1 · 14. Limit Controls - Hazardous Materials . 15. Splll Control, Drainage& Containment -. Hazardous Materials 16. Compressed Gases & Cryogenic Fluids -Control Area 2 [continued on next page] NOTE: Owner furnished/Installed equipment -not speclflcally related to building construction conditions Piping/tubing systems will be submitted for ~eparate plan check/permit. · • Pres~ure Control: • General: Not applicable to Isis conditions --. no· stationary tanks or equipment containing materials which can generate pressures exceeding the·tank or equipment design limits due to exposure fires or internal reaction. • Cryogenic Fluids: See Item 16. • Temperature Control: Not applicable to Isis conditions -no materials or conditions requiring temperature control. • Liquid Level Limit Controls: Not applicable to Isis conditions -no tanks, no piped systems for liquids. Not applicable to Isis conditions -i.e.: • No use/storage >Exempt Amounts. • No gravity transfer of Class I or II.Liquids from containers having a capacity >5.3 gallons [20 liters]. · + Flammable, highly toxic, inert and oxidizing qompressed gases and inert & oxidizJng cryogenic liquids will located be in the building. • Materials will be transferred through closed piping systems to use locations in Control Area 2; Same as Isis conditions -not applicable. Same as Isis conditions _._ not applicable. • General -Compressed G~se~ & Gryogens: • Storage: Cylinders/containers stored upright. • Valve Protection: Valves.protected-from physical damage by means of protective caps, collars or similar devices. · • Caps & Plugs: Caps & plugs in place. • Securing: Secured to prevent falling due to contact, vibration or seismic activity by one or c;:ombination of the following methods: * Cylinders secured to a fixed object with 1 or more restraints. * Cylinders secured on a cart or other mobile device designed for the movement of compressed gas cylinders. * Cylinders secured within a rack, framework, cabinet or similar designed for such use. • Storage Surface Area: Surface area beneath cylinders/containers to be constructed of materials compatible with the cryogens/compressed gases. +UFC/CFC 7403 + UFC/CFC 7503 + UFC/CFC Table 7902.5-A . + UFC/CFC Table 7903.2-B + UFC/CFC Tables 8001.15-A & B . + UFC/CFC 8003, 1.9 + UFC/CFC 8004.1.5 + LI.BC/CBC 307 .2 + UFC/CFC 7901.8 + UFC/CFC Table 7902.5-A + UFC/CFC Table 7903.2-B + UFC/CFC 7903.1.3.5 + UFC/CFC Tables 8001.15-B & B + UFC/CFC 7401-7403 +UFC/CFC75 + UFC/CFC 8001.16 . + U_FC/CFC 8004.1.1.2 + UFC/CFC 90 & Other Standards: • ANSI A13.1 ·• AN$! B31.3 • CGAC-7 • CGAG-9.1 • CGAG-10.1 • CGAP-1 • CGAP-12 • CGASB-15 • CGAS-13 • CGAV-1 'f' Eriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2] -Page 34 ~f 51 - ,. .. ... i I ' I ~ l , 1. l ! ~ ~ l h l i ~ ' l i ' i i ~ j i ! j l j 4 5 ~ ~ ~ -~ ~ I i 1 ~ -·,, ....-::::.; -· ----[l'.--c:;---· --. ·'-··-··,-1 ..... -·· . . ......,:.,_. ·.,---.i ' •t-,\::',d -~ ~ • -···--...J llll!IJ ---------1S1S PHARMACEUTICALS -1891 Rutherford, Carlt;;bad CA UNIFORM/CALIFORNIA CODE§_~NAL YSIS -181$ l..AB BUILD-OUT :· ..... :.·.:·2.;cod.{J-'~ondlti·i·C~;;~~~~~1l·'.?.?.J-1',;1/-':I1sl's'".'.,,i..···. ·.·=··'cij··.·t1~. , •. ~,c: ·n' 'ci;-tl .. ·.;.c .•. -... -:;,._z: :(········i'.'.! .. r.::-.. i.· .. '..·:'".·.·.;;.~--=-.:"" .... d; · .. :R.·. · . .-.quite.·., •. ments '&:c . 'd"tl ·ns ..... ' . . .. , ,... --~-,,-o..,,,, .... ,... -·~· .. " ,., ...... _ . ..,.,~-·~ .,. u .... _ .. . . o.. J .. pn.s .... ._.._ .. ". L·.--.L!:-... _ '"lo--~_. . . on , o .. 16. Compressed Gases I [See previous page.] & Cryogenic Fluids -Control Area 2 [continued) [continued on next page] 'NOTE: Owner furnished/Installed equipment -not specifically related to building construction conditions Piping/tubing systems will be submitted for separate plan check/permit. + General -Compressed Gases & Cryogens [continued): • Cont11lners: DOT approved containers. • Labe!lnglMarklng: Containers marked/labeled identifying contents. • Pressure Relief Devices: * Provide~ to prevent rupture in the event of overpressure. • Per CGA standards. • Valves: • General: · • Piping system(s) to contain a sufficient number of manual control valves & chec~ valves to operate system properly and to protect the area under b9th normal & emergency conditions. • Piping in connection with pumps to contain sufficient number of valves to controI·11quid floW in normal operation and in the event of physical damage or fire exposure. • Backflow Prevention/Check Valves: Provided when backflow,could create a hazardous condition or cause unauthorized discharge·. · • Emergency Shut-Off Valves: Identified with a sign/tag. •_Piping ~ystems: • G,naral: • Suitable for use intended [i.e.: copper, aluminum, brass, stainless steel); and • Dsigned/constl'l,lcted to provide allowam;:e-for expansion, contraction, vibration, settlement, fire exposure and maximum subjected temperatures and pressures. • Pipe Bends: Same. as indicated in Item 13. • Jolr,ts: Threaded, welded, silver-brazed or flanged. • Testing: Sarne as indicated in Item 13. • Identification: Same as indicated in Item 13. • Supports: Same as indicated in Item 13. • Location: • >/=3' from means of egress within the storage area. • >/=15' from combustible materials. • UFC/CFC 7401-7403 . tUFC/CFC75 • UFC/CFC 8001.16 t UFC/CFC 8004.1.1.2 t UFC/CFC 90 & Other Standards: • ANSIA13.1 • ANSl,B31.3 • CGAC-7 • CGAG-!;1.1 • CGA G-10.1 • CGAP-1 • CGAP-12 • CGASB-15 • CGAS-13 • CGAV-1 :,_ T Eriksen-Rattan Associates Inc. 4719 Palm Avenue, La-Mesa CA 91941 Technical· Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page 35 (!f 51 - ~ __ --L-rf .... ~:-~-r~:~ '·;::-...;, .. __ ~:::-~_:_:: .. ,J -.Z lilll~;--l -.. ·--: .... -ISIS PHARMACEUTICALS .. 1891 Ruth.erford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB. BUILD~our 16. Compressed Gases I [See previous page.] & Cryogenic Fluids -Control Area .2 [continued) [continued on next page] NOTE: Owner ,. furnlshe«tnnstalled equipment -not speclflcally related to·bulldlng construction conditions Piping/tubing systems will be submitted for separate plan check/permit. ,· -Y Eriksen-Ratian Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 • Flammable, Highly Toxic & Oxidizing Gas Systems: Equipped with emergency shutoff valves that can be activated at each point of use and at each source. • Cryogenic Fluids: • Pressure-Rellef Devices: • Pressure-relief devices to provided to protect containers/systems from rupture In the event of overpressure. • Containers to be provided with pressure-relief devices. • Heat exchangers, vaporizers, lnsulatton casings surrounding containers, ves!!els & coaxial piping systems In which cry~enic fluids could be trapped due to leakage from container to be provided with a pressure-relief device • • Pressure-relief devices to be sized per systems/container requirements specified by the supplier/manufacturer. • Pressure-relief devices to be accessible for inspection & repair. • Pressure-relief devices to-be arranged to discharge unobstructed to. the open air in such a·manner as to prevent impingement of escaping gas on personnel, . containers, equipment & adjacent structures to enter enclosed spaces. [NOTE: Not applicable to DOT · containers with an intemal'volume qf </=2 cubic feet.] * No shutoffs between pressure-relief devices & containers. * Pressure-relief devices not to be subjected to cryogenic fluid temperature except.when operating. • Pressure-RellefVent Piping: • Pressure-relief vent piping systems to be constructed & arrange.ti to remain functionai and direct flow of gas to a safe:location. • Piping to have a-cross-sectional area >/=that of the pressure-relief device vent opening & arranged to not restrict flow of escaping gas. + Piping & drains in. piping to be arranged so that escaping gas will discharge unobstructed to the open are and not Impinge on personnel, containers, equipment and adjacent structures of enter enclosed spaces. • Vent lines to be Installed to exclude or remove moisture and condensation and prevent malfunctton of pressure- relief device due to freezing or ice accumulation. + UFC/CFC 7401-7403 +UFC/CFC75 + UFC/CFC 8001.16 • UFC/CFC.8004.1.1.2 . + UFC/CFC 90 & Other Standards: • ANSI A13.1 • ANSI B31.3 • CGAC-7 • CGAG-9.1 • CGAG-10.1 • CGAP-1 • CGAP-12 ·• CGASB-15 • CGAS-13' • CGAV-1 Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2] -Page 36 of 51 - .. ·.:. ..... ,.; -'··: -·····-..... Wlliililila ff;'.'' ~-1if'·:ss-r.~-,···-· ··-·-----···· ···.·1 -·, _, ---·-· ·'-~ • ~ ~· ~ t:ii,-=~~•---.--. _ _. __ ..;_; <'{'•n,~ ;;•, _) ,.; • -I • ,.. t.•. ISIS PHARMACEUTICALS -1891 Rutherford,. Carlsbad CA l UNIFORM/CALIFORNIA CODES ANALYSIS -IBiS LAB BUILD-OUT j-. ~ 1. --.. ',>;,;.''-'?i'l,~'.><•j'l'l.•~i'"""*'c,",1· •. '1·;.-P.2,a' ,,---·a'•''"''e··o··t,·., .. ,,,:.1 -~ -·-·-a1·t·1·'0··-i:a::-,,, .. ·,"' .. ,-. '·l'cie:,,..: ' :.,,,.,.,.., .. PJ.t·~.:;:.,;t~ ~i~~jc;.~-i:'.t>.'·. l:11!, JTIL~ ... , ~a .. !lO,'iOnu . ,,s..:,:-·.',i': .. =:-£'· ,,:;;._-;: ;,~ · 16. Compressed Gases & Cryogenic Fluids -Control Area 2 [continued] [continued on next page] NOTE: Owner furnished/Installed · equipment -not speclflcally r,lated to building construction conditions Piping/tubing systems will be submitted for separate plan check/permit. [See previous page.] • Cryogenic Flul~s -continued: . • Marking, Slgnage, Identification: Containers & systems to marked/have signage as follows: •·Content~: Containers placarded to Identify contents and have hazard placarding as Indicated above. • Container Connections: Container inlet & outlet connections, llquid-level limit controls, valves & pressure gages to be Identified as follows: • Marked with a permanent tab ro sign Identifying their function, or Identified by a schematic drawing which portrays their function & designated whether they are connected to the vapor or liquid space of the container. • When a schematlac drawing Is provled, it is to be attached to container and.maintained In a legible condition. • Piping Systems: See Item 13. • Emergency Shut-off Valves: See Item 13. • Security: • Area: Area provided with security·to prevent unauthorized aecess. • Accidental Dislodgement: Secured to prevent acclden~I dislodgement for containers/systems. • Containers: . • Stationary-containers secured to foundations. • Portable containers secured to·preyent shifting or upset. • Equipment & Piping: • Vaporizers, heat exchangers & slmilar·equlpment anchored to a suitable foundation. • Connected piping to be sufficiently flexible to provide for the effects of expansion & contraction due to tempe~ture changes. • P.hyslcal Protection: Systems protected against physical damage & against tampering. • Separation from Hazardous Conditions: • General: See Item 5. •· Point of FIii Connections: Same as Item 5 conditions. • Surfaces Beneath Containers: Compatible with container contents. . +UFC/CFC 7401-7403 +UFC/CFC75 + UFC/CFC 8001.16 • UFC/CFC 8004.1.1.2 • UFC/CFC 90 & Other Standards: • ANSI A13.1 • ANSI B31.3 • CGAC-7 • CGAG-9.1 • CGAG-10.1 • CGAP-1 • CGAP-12 • CGASB-15 • CGAS-13 • CGAV-1 TEriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2] -Page 37 of 51 .. ,J ~ " ~ ~ ~ ~ t ! l ~ ~ j i t ' ; -3; i 1 IIIIIE -· -i-ma ii,:;.1~'- /lfr-.f,-qf-''"' .,,,_. __ ." .. _,_ .. ·, '•i --, ..... -· -~ ,tl'(f°: ~,t:o::.....__-,,__. _____ ! ,H~_..,J -• ._: • l . • -... -ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA · _UNIFORM/CAL_IFORNIA CODES ANALYSIS -IBIS ·LAB BUILD-OUT 16. Compressed Gases I [~ee previous page.] & Cryogenic Fluids -Control Area 2 [continued] NOTE: Owner · furnished/Installed equipment -not speclflcally related to bulldlng construction conditions . Piping/tubing systems will be submitted for separate plan check/permit. --.... Eriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 + Cryogenic Fluids -c:ontlnued: • Electrical Wiring & Equipment: • Containers/systems not to be-located where they could become part of electrical circuit. • Containers/systems not to be used for electrical grounding. • Lighting: _ • Lighting, Including emergency lighting to be provided to illuminate fire appliances and operating facilities such as walkways, control valves & gates ancillary to stationary containers. • Emergency lighting can be provided through storage batteries ->/=1.5-hour duration. • Piping Systems: • General: See Item 13. • Joints: Joints on container piping/tubing to be threaded, welded, silver-brazed.or flanged. • Valves & Accessory Equipment: Suitable for Intended use and designed/constructed to withstand maximum pressure at minimum temperature to which subjected. • Shutoff Valves: • Container Connections: • Provided on all oontalner connections, except for pressure-relief devices. • Accessible & located as close as practical to the container. - • Piping: • Installed on piping when needed to limit volume of liquid discharged in event of piping/equipment failure. • Pressure-relief valves Installed when liquid can be trapped between shutoff ~Ives 'in the piping system. • System: Provided at supply·and poinf(s) and where system enters the building. • Physical Protection.& Support: • Piping to be well supported & protected from physical damage. • Piping passing through walls to be protected from mechanical damage. • UFC/CFC 7401-7403 . +UFC/CFC75 + UFC/CFC 8001.16 + UFC/CFC 8004.1.1.2 • UFC/CFC 90 & Other Standards: • ANSIA13.1 • ANSI B31.3 • CGAC-7 • CGAG-9.1 • CGAG-10.1 • CGAP-1 • CGAP-12 • CGA.$B-15 • CGAS-13 • CGAV-1 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page _38 o_f 51 - ;;· ... .... -.. --r._ '·-·'.?-wg,, rl-ift!"-"s-:·w·s&, ..... -,_ ·, IIIIL': -.--: -·.51 _.. -·-'.-· --· .. . ' -. t.. ' ~----·li)il; I!'_~ ~-... ...., ·--' -...: -.,,.,, -.;i . ~ ' . ~ --,_. .. ISIS PHARMACEUTICALS ·• 1'891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA copes ANALYSIS ~ IBIS LAB BUILD-OUT ' .• , .,:·,_c·. ,.,., .-',,j,i1a.r·n''"1t' 1·::.1.;.t ';;1;-'i'•1 i·'-';trcs,·,,:,;a,w •. •11···'·e" lllr'_ '='a,l.'>i;.-lt' l.:.Ul>Ji.:"r.t-all.,;;.l.l~tlo·'·n· s· \ ,\.,':= ~· •·7 1 ., ... ~-·~•"''-·;•"C'o' ""e" be· 'q"u·· t'r"i-m' "'e' .......... '&"C' o".i.dltl'o· n's ~'::i-· · ~u,.;~~-~I .u,~~{::;::=;~·· ::t~~ .. )I::~i-·: ~?: .i., .". &.fl.{.llJ.al.iv.u ~ ~~~~agul,_ ~. ~~;l.':{~;;. ~8:··! -~-• .. ,:_.~,~-,i,~ . .;.~ 1.:1 __'.:_~-----,_..__,, ___ ,_,.,.,.~-~··.'._,__ ___ 11_. _______ _ · 17 •. Equipment, Machinery, Tanks, Vessels&·· Processes- Haz.ardous Materials . NOTE: Owner furnished/Installed equipment -not.specifically related to building construction conditions. 18. Ignition Source Control +General: Equipment, machinery, vessels & processes I Same as Isis conditions. to be approved, listed or designed and constructed in accordance with approved standards for the intended use. • Tanks: Not applicable to Isis Pharmaceuticals conditions -rto tanks. +General: Isis Pharmaceuticals has indicated that the control of ignition sources, including electrical equipment, wiring and devices, will be in accordance with.applicable Code conditions and requirements. • Open Flames & High Temperature Devices: None -- not applicable to Isis Pharmaceuticals conditions. • Electrically Classlfled Areas: See Item 9. • Prevention of Static Electricity -Class I Flammable Liquids: Precautions will be taken to prevent the accumulation of static electricity. See Items 11. • No Smoking & Signage: "No Smoking" signs will be posted although State law prohibits smoking inside the building, making signage both redundant & unnecessa Saine as Isis conditions. T Eriksen-Rattan.Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 • UFC/CFC 7902.1.8 • UFC/CFC 7902.1.11 + UFC/CFC 7902.2.5.10.2.2 + UFC/CFC Table 7902.1-A + UFC/CFC 8001.4.5 + UFC/CFC7901.4 +UFC/CFC 7901.10 + UFC/CFC'8001.9 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page 39 of.51 - -" ---. . ;..... ra-liiliilllla ~,'iililii ~: llllllllla ~ ~ , ...... ,_ --·,--'-·:-·: -· . -· ... ---r?-? ~-~ ...... r--"--·~~..n·~ ~ __ ; ~ !-. ' ~· ,s1s PliARMACEUTICALS -1891 Rutherford, Carlsbad.CA UNIFORM/CALIFO~NIA CODES ANALYSIS -IBl'S LAB BUILD-OUT '·~~\'?:~~?lf!f~~~:l~~-·~-~.;·1sls:.f'fil_~cei.m~1s;·coffc1niciosT.i·:: ~---';' :: -.1::: ;~-: ;;~-s:'.··cfid.,ii'-~'qu1r,1n•nts. & ·_c:onditioiis · 19. Lighting [continued on next page) Out!!ide the scope of this report -Code Requirements & Conditions provided for information only. +General: • Adequate lighting·by natural and/or artificial means to be provided. • Artificial lighting to be in accordance 'Mth the IES Lighting Handbook and California Energy Standards. +Exit Signs & Sign lllumlnatlon: • General: Path of exit travel to and within exits in building to be identified by exit signs in accordance with UBC/CBC 1003.2.8 requirements. • Locations: Exit signs shall be-located as follows, except for main exterior exit dOQrs and rooms/areas that required only one [1] exit c;,r·exit access: • Exit slg"'s to be readily visible from any direction of approach. * Exit signs to be located.as necessary to clearly indicate direction of egress travel. * No point to be more than 100' from the nearest visible exit sign, · • lllumlna•lon: Exits signs to be illuminated at all times in accordance with one [1] or combination of the following conc,litlons: * Approved-self-luminous signs, with >/=0.06 floor Lambert. • Approved internally illuminated sign!! having light- emitting diodes or electroluminescent lamps. * Internally or externally Illuminated, with >/=5 foot- candle intensity. Internally illuminated signs to be listed. • Power Supply: One [1] or combination of the following: • Approved self-luminous signs providing continuous illumination independent of an external power source. * Emergency system [storage batteries ->/=1.5 hours]. +-UBC/CBC 1003.2.8 + UBC/CBC 1003.2.9 + UFC/CFC 7501.14 . +UFC/CFC 8004.1.9 TEriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2] -Page 40 ~f 51 - 11111[; ---r-····-.. t~ g,c ___ .,, ~-~ ~ . ,,?-;; r,-;, ..... ·--· ···:·· ._ .. , ···-· ··'"\ :c.{;··:*' _ w,......,.M\: ,..___ __ .. __J _ 4.._ • ..., ,,.4 ...; .. j -----ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT 21. Portable Fire Extinguishers NOTE: Owner fumlshednnstalled equipment -not speclflcally · related to bulldlng construction conditions. -· 22. Water Supply -Fire Sprinkler System & fire Flow 23. Fire Department Access NOTE: Rev. 2 Changes 24. Material Handling & Transportation in Building - Hazardous Materials· +Gener;.!: • Dry Chemical [ABC] or CO2 portable fire extinguishers will be provided in accordance with applicable Code requirem~nts. • Owner furnished/owner ins~lled equipment. • Size & Location: · • Hazardous Materials & Storage Locations -No Class I, II or III-A Liquids: • 2A208C. • Within 50' of travel. • Class I, II or III-A Liquids Storage or Use Areas: • 4A40BC. • Within 30' of travel. • Other Areas: • 2A108C • Within 75' of travel. Existing builc,Jing -~xisting condition~ are presumed to comply. Existing building -existing conditions are presumed to comp!y. NOTE: Fire department access doors for hlgh:piled · combustible storage conditions in Room L 197 [197) not -reouired -storage area/warehouse <2,500 sf. _. + Transport of Hazardous Materials In Exit Corridors/Exit Enclosures: Not applicable to Isis conditions -hazardous materials will not be transported through exit corridors or exit enclosures. • Powered Industrial Trucks/Forklifts: Not applicable to Isis conditions -no powered industrial trucks/ forklifts. Same as Isis conditions. · Existing building -existing conditions are presumed to comply. . Existing building --existing conditions are presumed to comply. • Tran~port of Hazardous Materials In· Exit . Corridors/Exit Enclosures: Same as Isis conditions --· not applicable. • Powered Industrial Trucks/Forkllfts: Same as Isis condiJjons --not applicable. + UFC/CFC 1002 + UFC/CFC Std 10-1 + UFC/CFC 903.2 + UFC/CFC 903.3 t UFC/CFC Appendix Ill-A . + UFC/CFC Appendix 111-B + UFC/CFC 901.4 t UFC/CFC 902.2 + UFC/CFC 902.3 + UFC/CFC 902.4 + UFC/CFC 8102.6.2 t UFC/CFC 1108 + UFC/CFC 7901.12 + UFC/CFC 8001.12 +OSHA: • CFR 1910.178 • CFR 1926.403 ····- 'f'Eriksen-Ratlan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 (Rev. 2] -Page 44 of 51 - .. --.. --·f."'f-"''··-~-r"''·'<'·-,, ... ·.,-,.·,-·,-·, ,,.--,·-; -------. • ~=-~ ·~. ~{fJ.t ~~~ .... ,.,..._ • --~ -u~ ~~ ·'-J .! ......: : . ·--....l· : ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT _ 25. Storage Arrangements - Hazardous ·Materials & Warehouse NOTE: Owner fumlshednnstalled equipment -not speclflcally related to bulldlng construction conditions. NOTE: Rev. '2 changes +Compressed Gases: See items 16& 26. +.Cryogenic Fluids: See Item 16. I. Same as Isis conditions. • Shelf Storage -Outside Cabinets: Owner provided/owner installed equipment as follows: • Shelves: • Construction: Steel. • Storag11 Helgt,t: . • General Storage: </=9' high. • Class I, II &. Ill-A Liquids: <6' above finished floor. • Shelving Depth: </=30" deep. • Distance Between Shelves: </=3' between shelves. • Bracing: Will'be seismically braced. • Displacement Protection: Lips/guards provided to prevent accidental dislodgement of individual containers of ha~rdous materials stored on shelves. • Aisles: • Main Aisles: >l=44" • • Cross Al~les: >/=24" . • Dead-Ends: </=20' +Rack Storage [Warehouse Only-Room L197 (197)~ • Commodities: • Class !-IV -cartoned, uncartoned, palletized, non- . palletized. • High Hazard/Group A Plastics -cartoned, palletized, nonpalletized • Construction: • Steel. • Seismically braced • Storage Height: </=20' above finished floor. • Aisles: • Main Aisles: >/=44". • Cross Aisles: >/=24" • Dead-Ends: </=20' • Transverse Flue Spaces: >/=3" • Laboratory Cabinet Storage: Owner provided/owner installed equipment. • Flammable Llquids/t1azardous Materials Storage Cabinets: See Item 26. • Gas Cabinets/Exhausted Enclosures -Highly Toxic Gases: See Item 26. • Clearances to Sprinklers: >/=18" from top of storage to sprinkler deflectors. 'f'Eriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 + UFC/CFC 1103.3.2 +UFC/CFC74 + UFC/CFC 75 • UFC/CFC 7902.5 + UFC/CFC Table 7902.5-C . ,. UFC/CFC 8001.11 ,9 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page 45 o! 51 ··~·:..,:._~ --- ,. , __ ?,f· ~--<'ff-~-'-, .. ··--··· --"'' --, .. -~ J . ~,....... "~">: --~z-~~..:'\, !.~,..__: .--1' .,....,;, ~--~ . -~-.-...... -ISIS PHARMACEUTIC.Al-S -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT ···· ·.··~~t,:2rW:;1/,~~~:1%-.t~ts_ls'.P.ftatitiaciH.it[cals·.06nct1ttQn's\ .... :.~, · -1:_:·:q?:, : ··::;·~\~,~.c~li~t':Re§Ulre_rilants · &'·conditions: 2.6. Approved, Storage Cabinets, Gas Cabinets & Exhausted Enclosures - Hazardous ft'!aterlal~ [contlnu~ on next page] NOTE: Owner fumlshedilnstalled . equipment -nol'speclflcally related to building · construction conditions. +Separation of Incompatible Materlal.s: See Item 4 - storage cabinets, if used, will comply with applicable Code requirements. · + Increase Exempt.Amounts par CC?ntrol Area: • Control Area 1: Storage in cabinets not specifically required. , • Control Area 2: Storage in cabinets required for the following conditions: • Physical Hazard Materials: • Flammable liquids 1-8: >/=22 gallons • Pyrophoric Liquids: >/=0.05 gallon • Unstable Reactive 3 liquids: >/=0.06·gallon • Health Hazard Materials: Not specifically required. • Highly Toxic Gases: R!'lquired to be le>cated in gas cabinet or exhausted enclosure for both storage & use conditions, with cabinets/enclosure connected to an exhaust system. • Flammable Liquids Storage Cabinets: • General: • Signs: FLAMMABLE-KEEP FIRE AWAY -red letters.· on contrasting·background. • Maximum Quantity per Cabinet: </=120 gallons per C!!binet. • Doors: Self-closing & equipped with.a latch. • Bottom: Liquid tight to a height >1=2". . • Type: cabinets either listed or constructed as described below. • Unlisted Steel Cabinets: • Construction: • Steel -->/=18 gage. • Double walled pncluding door], wllh 1-1/2" airspace between-walls. • Joints: -Riveted or welded. • Unlisted Wood Cabinets: • Construction: >/=1" exterior grade plywood. • Joints: Rabbited and fastened In 2 directions with wood screws. • Door Hinges: Steel or brass. • Paint: Cabinets painted with intumescent-type paint. • Hazardous Materials $forage Cabinets: • General: • Signs: HAZARDOUS MATERIALS -KEEP FIRE AWAY -red letters on contrasting background. • Construction: Metal construction. • Interiors: Interior treated, coated or constructed of material!!_nonreactlve with.materials stored therein, • Type: Cabinets either listed or constructed as described below. • Unlisted Cabinets: • Construction: • Steel ->/=18 gage. • Double walled Pncluding door], with 1-1/2" airspace between walls. • Joints: Riveted or welded. • Doors: Self-closing & self-latching. • Bottom: Liquid tight to a height >l=2". • Gas Cabinets: •IADD + UFC/CFC 7902.5.9 +UFC/CFC 8001.10.6 + UFC/CFC TablEl 8001.15-B + UFC/CFC 8003.3.1.3 l'Eriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page 46 of 51 - .. -- '·-l'-f'-t;r,:··-':f!_:J!Kf-e'J.·:,;;< :···-C·'·:·,-. ··-· ·. -I_,,:; ;_ ~........ ~ ~ ~~ ~r~ _,, .... :-.. ..,:;.~ ,,.,_.,..,.-: .,.. __ ; • ~-:..~P ~ -~: --~ -·-·,-,.---·-ISIS PHA8MACEUTICALS -1"891 Rutherford, Carlsbad CA ' , UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT 26. Approved Storage Cabinets, Gas Cabinets& Exhausted E_nclosures .,. Hazardous Materials [contln!Jed] NOTE: Owner furnished/Installed equipment -not speclflcally related to building consfructlon conditions. [See previous page.] ?Eriksen-Rattan Associates Inc. 4719 Palm Aven~e. La Mesa CA 91941 +·Gas Cabinets -Highly Toxic Gas,s: • Negative Pressure: Operate at negative pressure relative to the surrounding area. • Access Ports/Windows: Self-closing limited acce1?s · ports or noncombustible windows to pro.vide access to equipment controls. • Exhaust Ventilation: • Velocity: · • Average vel<>city of ventilation at face of access P9rts/windows at >/=200 fpm. • >/=150 fpm at any point of the access port/window. • Exhaust System: Connected to an exhaust system. • Treatment System: Exhaust ventilation directed to a treatment system. • Doors:-Self-closing doors. • Coristnictlon: Constructed of. >/=12 gage steel. • Cylinders per Cabinet: Maximum 3 cylin9ers per cabinet. +Exhausted··Enclosures -Highly Toxic Gases: • Negative Pressure: Same as gas cabinets. • Exhaust Ventilation: Same as gas cabinets. • Treatment System: Same as g·as cabinets. • Construction: . • Approved noncombustible materials. • Consist of a top, back·& 2 sides. + UFv/CFC 7902.fi.9 + UFC/CFC 8001.10.6 . +UFC/CFCTable 8001.15-B + UFC/CFC 8003.3.1.3 Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2] -Page 47 of 51 .. 'F'·"'·--· ....... l-·. _-, ... ''.;': -·: ~~~ ... ,,....,..,._, ~--:J ~ """" ---,_ ~~---!,1-'~ ( ~ Gf:i -lf/./-::t: ~ ~~ ~;-,: ,l--1 illlll :-__ ::- 1$1S PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFO~I\II/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT 27.-Hazard Isis Pharmaceuticals has indicated that hazard identification signs will be provided .in accordance with applicable City of Carlsbad Fire Department r~quirements. · +General: • Hazard identification signage-may be required by the I • UFC/CFC 8001.1 _ Identification Signs NOTE: Owner furrilshectnnstalled equipment -not speclflcally related to building c:onstructlon conditions. ' TEriksen-Rattan Associates Inc. 4719 Palm Avenue, La M~a CA 91941 Fire Department. · • Signs, If required, are normally required to be placed in the following locations: * At entrances to and within each Control Area. * On vessels involved with liquid transfer operations. -• Signs are generally required to be In accordance with the following: . * Measure 15-inches on each side. * Have white reflective letters/numbers on blue or red backgrounds and .black reflective letters/numbers on . white and yellow backgrounds. + ~ulldlng & Tenant Improvement Area: • Health: 4 • Flammablllty: 4 • Reactivity: 3 • Special: COR OX WR + Compressed Gases: Rooms and cabinets containing compressed gases to have slgnage indicating COMPRESSED GAS. - + Compressed Gas & Cryogenic Fluid Vessels: Signage or otherwise-marked to indicate contents. . ( Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page 48 o! 51 - ! ! lalll'. --"-;;,Z,-w.'-r:·-r-:e-.-.·-•-?J·"*-'·.'· ·-· ··----· ·, ---,, -·, ~ ~~-~~~-~ -~ -~ 111111) -\-·---·-ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -U31S· LAB BUILD-OUT 28. Premises ldentiflca,tion. 29. Emergency Respons·e, Training & Procedures · ,[continued on next page} NOTE: Owner administrative conditions -not specifically related to building construction-conditions. E>dsting conditions are presumed to comply. + Materials Safety Data Sheets [MSDS]: MSDS will be maintained on-site in a. location acceptable to the City of Carlsbad Fire Department. • Hazardous Materials Inventory Statements [HMISJ: Inventory information provided In Attachment 1. +Personnel Training &Written Procedures: • Employees will be trained to be-familiar with the chemical nature of the materials and appropriate mitigating actions necessary in the vent of fire, leak orspill. · • Persons will be designated & trained to be liaison personnel for the City of Ca_rlsbad Fire Department as determined to be necessary by the City·of Carlsbad Fire Department -i.e.: aid Fire Department in preplannlng emergency responses & identification of hazardous materials locationslconditions. • Emergency Equipment: Provisions will be made for controlling/mitigation leaks/spills [i.e.: clean-up materials, dispo~al p~ocedures, etc.); • Hazardous Material~ Management Plan [HMMPJ: Isis Pharm.aceuti~ls has indicated that a Hazardous Materials Management Plan, if required, will be provided in accQrdance with applicable Code requiremen~. TEriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 Existing conditions are presumed to comply. • Materials Safety Data Sheets [MSDS]: Same as I.sis conditions --location to be approved by City of Carlsbad Fire Department. + Hazardous Materials Inventory Statements [HMISJ: Same as Isis conditions. • Personnel Training & Written Procedures: Same as Isis conditions, as required by the City of Carlsbad Fire Department. · • Emergency Equipment: Same as Isis conditions. + Hazardous Materials Management Plan [HMMP): To be provided as required by the Fire Department and and/or other agencies. Plan to include the following information, In addition to other information that may be · reqµlred by the authorities having jurisdiction: • General Information: Business name, addrel?S, emergency contacts, business activity-, owner·or operator, SIC code, number of employees & hours., signature of designated repres~ntative. • Site Plan: * Drawn to scale. * ·Location of location of building, exterior storage facilities, permanent acces.s ways & evacuation routes, parking lots, internal roads, chemical loading & loading areas, equipment cleaning areas, storm & sanitary sewer accesses, emergency equipment & adjacent property line~. • Building Floor Plan: * Drawn to scale. * Hazardous materials storag·e & use areas, rooms, doorways, corridors, means of egress and evacuation routes. * Contents of storage areas identified. + UFC/CFC 901.4.4 + UFC/CFC 8001.3 • UFC/CFC App. 11-E +OSHA: • CFR 1910.178 • CFR 1926.403 Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2) -Page 49 of 51 - ... :. --L-~ ~ ... -r ~ r.e·; .. ~i::-· ._!.::-~ \)!ll=:t .. JJ"i, __ _ _,. , ... ,:--'---'. ·;--·· ., -,. ·, --·(: ......-: -; ----:--',_ -· • ~··--·--' b~ ' ~ ----; ' ... ..... ~,,., .. ISIS PHARMACEUTICALS -1891 Rutherford,-Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT ·_ .:_,_,.,:·,:code~Cc),ficiltt~fi'D:~it~~!:t~~-;:---1.1s~.i'ftlirntfic~a1ls~lticW1aZ~s&il:coc1_a ... ii41qillreimtW:&'.Condltlons·.· .. 29. E;mergency Response, Training& Procedures [continued] · NOTE: Owner administrative conditions -not speclflcally related to building . co,nstructlon conditions. [See previous page.] l'Eriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 • Hazardous Materials Manag~ment Plan [HMMP] - continued: • Hazardous Materials Handling: • Description of activities involving handling of hazardous materials between storage & manufacturing areas. • lnfonnation showing how such-operations are conducted to prevent accjdental release of ·hazardous materials. • Material Compatibility & Separation: Identification of controls used to ensure separation of materials & conditions incompatible with each other. • Monitoring Program: Description of monitoring methods used re types and amounts of hazardous materials on-site. • Inspection & Record Keeping: Written procedures for schedules & procedures for inspecting safety & monitoring and emergency equipment. • Employee Training: Written procedures.for employee training to prepare employees to safely handling h~zardous materials on a daily basis and during emergencies -i.e.: • Instructions-in safe-storage & handling-of hazardous materials, Including maintenance of monitoring records. • Instructions In emergency procedures for leaks, spills, fires or explosions, Including shutdown of operations & evacuation procedurf:ls. • Record-keeping procedures for documenting employee training. · • Emergency Response: Written description of facility emeri:iency response procedures.· + UFC/CFC 8001.3 + UFC/CFC App. 11-E +OSHA: • CFR 1910.178 • CFR 1926.403 Technical Report-Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2] -Page 50 o~ 51 - --__ L_ n~·-;;;,...-,,,,_____ ' -.... , -· ., ......_,,.,. ----.... -·· ;~~~~:..~_,_: ..... ; -.:.-..,:." .....,..; ...: ' -:, _____ :,." .. ISIS -PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT · 30. Special Use Fire Department Permits & Plans NOTE: Owner administrative conditions -not speclflcally related .to building construction conditions. Special use Fire Department permits will be obtained as required by the City of Carlsbad Fire Department. 'YEriksen-Rattan Associates Inc. 4719 Palm Avenue, La Mesa CA 91941 + Hazardqus Materials Conditions:·. Permits and plans may be required by the City of Carlsbad Fire · Department. If required; the following information is generally required to be provitled: • Building floor plans & outdoor plans showing locations of hazardous and conditions of operations-involving hazardous materials, including a storage-plan. • Locations of emergency isolation and mitigation valves & devices. • Product conveying piping containing hazardous materials liquids or gases. • On & off positions of valves for valves which are of the self-indicating type. • Type of and design of fire-extinguishing systems. • Location of valves controlling-water supply of sprinklers. · + Storage Conditions: Permits and plans may be required by the Fire Department. + Egress Plans: Fire Department may require that approved egress plans be posted throughout the building. + UFC/CFC 4501.3 + UFC/CFC 6202 + UFC/CFC 7901.3 + UFC/CFG 8001.3 Technical Report -Hazardous Materials & Storage Operations Code Requirements & Conditions -12/14/01 [Rev. 2] -Page 51 o~ 51 - ,,., ... I I I I I I I I I I I I I I ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT ATTACHMENT 1-A-CONTROL AREA 1 HAZARDOUS MATERIALS INVENTORY ANALYSIS 1~ November 2001 [Rev. 1] · Prepared by ~ Eriksen-Rattan Associates Inc. 4719 Palm Avenue La Mesa, California Telephone 619.466.6285 FAX 619.466.6233 EMAIL MaryRattan@thecoderesource.com or MaryRattan@covad.net Unless otherwise Indicated, the storage amounts the maximum amounts in use and storage at any time, with use amounts <10% of the amounts indicated for storage. Not all Inventory Items listed will be in use at the same tjme. I I I I I I I I I I I I I I I I I I·· I ISIS PHARMACEUTICALS • 1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS • IBIS LAB BUILD-OUT .. :-·.\:.:?:-.~:~·-:\)·; ·>··-... ,: .. ,:~--,\··.A,,.ACHMiN;~,~,l~:j:e&Ntiiot-~El:1=:.-:-: _ _.--i>:, .. ~.-... :·: ·:::. · .. _· ,_· . .'. :. . ·< · HAZARDOUS :MATERIALS;·INVENTORY ANALYSIS'_' ' :.:_ .. )i·:-_:~_.~:.:~·:·_::----·:·-·::= ,·:::i::_.-.::·~_.'._,:.·:_·-._.~-~-~~~Y:~.-~~~~{;r~~-~-T~'.;'.'i:;t··\-,::·-· 13 November 2001 [Rev. 1]. Prepared by T Eriksen-Rattan Associates Inc. 4719 Palm Avenue La Mesa, California Telephone 619.466.6285 FAX 619.466.6233 EMAIL MaryRattan@thecoderesource.com or MaryRattan@covad.net . ·-. Unless otherwise Indicated, the storage amounts the maximum amounts In use and storage at any time, with use amounts <1 Oo/, of the amounts Indicated for storage. Not all Inventory Items listed will be In use at the s~me time. -- ~~ , .. I?,/;; · ..... !_ . -·. _ .. \ -:I , ~ L i'rr'"o !(;11,.;..;;J___ r,r;.,,,,::J~ -----1 -.·:w .1 HAZARDOl,IS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-D • UFC/CFC TABLES 7902.5-A, 7903.2-B, 8001.15-ASUMMARY • PHYSICAL HAZARD M~TERIALS Isis.Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Carlsbad CA -Control Area 1/Chemical Waste Storage STORAGE USE CLOSED Solids Liquid ,Gas Solid Liquid Material Lbs Gins. Cf Lbs Gins Combustible Liquids II 4,7551 -· Flammable Liquids I-A 5.2835 Flammable Liquids I-B 48.9495 Gas Cf 1997/1998 CODES: S1 OCCUPANCY CONDITIONS BASED ON THE USE and STORAGE OF PHYSICAL HAZARD MATERIALS. L 114: Class I, II and Ill-A Liquids: Storage and liquid transfer operations. Building Is protected throughout by an automatic fire sprinkler system. .. -.. : .. · .. -···- USE OPEN Solid Liquid Gas Lbs· Gins Cf 0.2642 0.2642 2.6420 . SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 1 - --1:.--, ...... "'f'~-""l"i" r -~ t__.... ~~ ~~ ,,.,,-·.--·· ·-·: -··· '-~~-~--·--~ J HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS USC/CBC TABLE 3·D -UFC/CFC TABLES 7902.5-A, 7903.2-8, 8001-.15-A SUMMARY -PHYSICAL HAZARD MATERIALS Isis Pharmaceuticals/Ibis laboratory-1891 Rutherford, Carlsbad·CA-Control Area 1/Chemlcal Waste Storage " ...... bi.lstlb &'1'1n"lds ,r,·<:·,~-.~_;;;:;;.;p, 1f-·;,~~r·;·,:. ,.:.7.,:•.>';'Jc-~::,; .. ,, 1 ·storage··I I Units I ":"':'11.J. t '<'•~'''"' ,._.!:"l!'fH. __ .. ,;J;:-J~iJ.J"-,\, .,:;,.l':..:-·.:-.. :.:..;.·;:!,.·.,.~.':"'~~:--,·,\o·,t . .-·)15.·~·.,: • . w .. -.,. 1 -·-_ , TOTAL Combustible Liquids II (LIQUIDS) 4.7551 Gins AGGREGATE TOTAL Combustible Liquids II ILIQUIDSJ: 5.0193 GALLONS LIQUIDS HAVING FIRE POINTS• 1997 UBC TABLE 3-0/IJFC TABLE 7902.5-A EXEMPT AMOUNTS PER CONTROL AREA: STORAGE & USE CLOSED• H-3 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. USE OPEN & PRESSURIZED SYSTEMS >15 PSiG • Ha2 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. STORAGEiAGGREGATE EXEMPT AMOUNT -NO CABINETS: 240 GALLONS STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: 480'GALLONS USE CLOSED EXEMPT AMOUNT: 240 GALLONS USE OPEN EXEMPT AMOUNT: 60 GALLONS LIQUIDS WITHOUT FIRE POINTS -1997 uec TABLE 30D/UFC TABLE 7902.5-A, 7901.1.1/Exception 9 EXEMPT AMOUNTS PER CONTROL AREA: STORAGE: UNLIMITED U!,~ CLOSED EXEMPT AMOUNT: 240 GALLONS USE OPEN EXEMPT AMOUNT: 60 GALLONS MEDICINES, FOOD;·COSMETICS, ETC. -1997 UFC 7801.1.1/EXCEPTION 3: </s 50% WATER MISCIBLE FLAMMABLE/COMBUSTIBLE LIQUIDS & CONTAINERS</ ... LITERS: UNLIMITED GROUP M OCCUPANCY • MAXIMUM QUANTITIES PER CONTROL AREA -1997 UFC TABLE 7802.5-B ·COMBINATION 1-B, 1-C, II, Ill-A: CEILiNGS </=18' HIGH -</=6' SHELF STORAGE, </=4.5' OTHER STORAGE: 7,500 GALLONS SPECIAL SPRINKLER SYSTEM PROTECTION: 15,000 GALLONS . F!~~l!i!!&1,,,LJgi.,1kJl.1.1~1;;t,;r1,¥1-~;f;'1.lVi:!/t.'i;;,r·'.'tf:':il~; ~.;,. ,..,L""'§J,,..,l)fa,...:.--..s1-~, .. J lW!lti I TOTAL Flanimablf: Liquids I-A. (LIQUIDS] AGGREGATE TOTAL Flammable Liquids 1-A '(LIQUI_DSJ: 5.2835 Gins 5.5477 GALLO_NS LIQUIDS HAVING FIRE·POINTS • 1997 UBC TABLE 3-D/UFC TABLE 7902.5-a EXEMPT AMOUNTS PER CONTROL AREA: · STORAGE & USE CLOSED • H-3 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. . USE OPEN & PRESSURIZED SYSTEMS >15 PSIG • H•2 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. 'STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: . 60 GALLONS STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: 120 GALLONS USE CLOSED EXEMPT AMOUNT: 60 GALLONS USE OPEN EXEMPT AMOUNT: . 20 GALLONS LIQUIDS WITHOUT FIRE POINTS,-1997 UBC TABLE 30D/UFC TABLE 7902.5-A, 7901.1.1/Exception 9 EXEMPT AMOUNTS PER CONTROL AR~: STORAGE: UNLIMITED USE CLOSED EXEMPT AMOUNT: 60 GALLONS USE OPEN EXEMPT AMOUNT: 20 GALLONS MEDICINES, FOOD, COSMETICS, ETC.• 1997 UFC 7901.1/EXCEPTION 3: <I= 50% WATER MISCIBLE FLAMMABLE/COMBUSTIBLE LIQUIDS & CONTAINERS </=4 LITERS: UNLIMITED GROUP M OCCUPANCY• MAXIMUM QUANTITIES PER CONTROL AREA~ 1997 UFC TABLE 7902,5-B: 80 GALLONS L 114: Class I, II and Ill-A liquids: Storage and liquid tran~fer operations. . l 117: Class I, II and Ill-A liquids: Storage only-no use or transfer conditions Building Is protected throughout by an automatic fire sprinkler system. -: -:-:.:--.--··- ~l !U~lts! !:·.UO !Units! Gins 0.2642 Gins k· u..q ,-:~ I 1u.n1tsl · UO: :-1 !Units! Gins 0.2642 Gins .. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 2 s - ·:· ·~· -.. Yf--f~-~ L~ ,,~-"5-·1,-·-~ -...... ,_. : IIIIL .! -'-: -·· ~ ...J£.1~ .. , • .;,..;.,...,) .~"'!'-= __; ..,-.,JI ~ HAZARDOUS MATERIALS.and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE'a-D -UFC/CFC TABLES 7902.5-A, 7903.2-B, 8001.15~ASUMMARY • PHYSICAL HAZARD MATERIALS lsls,Pharmaceuticals/lbis Laboratory -1891 Rutherford, Carlsbad CA -Control Area 1/Chemical Waste Storage F1~m~1;,1~k-~ · ~J~$.:;h~$~'.::I=~~}.~F,~;~r::;;,_~:·, :,,n??lf.Z;:11;·~} 1· st~e•· I t1,1"1tjS I TOTAL Flammable Liquids l~B {LIQUIDS] 48.9495 Gins A~GREGATE TOTAL Flammable Liquids 1-B (LIQUIDS]: 51.5915 GALLONS ' . LIQUIDS HAVING FIRE POINTS• 1997 UBC TABLE 3-D/UFC TABLE 7902.5-a EXEMPT AMOUNTS PER CONTROL AREA: STORAGE &·US!: CLOSED -H-3 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. USE OPEN & PRESSURIZED SYSTEMS >15 PS1G • H-2 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT. NO CABINETS: 120 GALLONS STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: .. 240 GALLONS USE CLOSED EXEMPT AMOUNT: 120 GALLONS USE OPEN EXEMPT AMOUNT: .30 GALLONS LIQUIDS WITHOUT FIRE POINTS-1997 UBC TABLE 30D/UFC TABLE 7902.5-A, 7901.1.1/Exceptlon 9 EXEMPT AMOUNTS PER CONTROL AREA: STORAGE: UNUMITED USE CLOSED EXEMPT AMOUNT: 120 GALLONS USE OPEN EXEMPT AMOUNT: 30 GALLONS MEDICINES, FOOD; COSMETICS, ETC. -1887 UFC 7801.1/EXCEPTION 3: </• 50% WATER MISCIBLE FLAMMABLE/COMBUSTIBLE LIQUIDS & CONTAINERS </'"4 LITERS: UNLIMITED . GROUP·M OCCUPANCY• MAXIMUM QUANTITIES PER CONTROL AREA· UFC TABLE 7802.5-B • COMBINATION I-B, I-C, II, Ill-A: . CEILINGS </=18' HIGH -</=6' SHELF STORAGE, </=4.5' OTHER STORAGE: 7,500 GALLONS . SPECIAL SPRINKLER SYSTEM PROTECTION: 15,000 GALLONS L 114: Class I, II and Ill-A Liquids: Storage and liquid transfer operations. L117: Class I, II and Ill-A Liquids: Storage only-no use or transfer conditions Building is protected throughout by an automatic fire sprinkler system. -: --=-~ ·-·-'""'- L:uc I !U!llts! l .-uo .. l tun1tsj Gins 2;6420 Gins ' HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 3 - --- . <'.':11111•'>':_f,.,.',--~,=' ._,_,,,,_ ...... ----........ , lllliliilil··~ --···· -,-· --·-----· . ' t:.· ~~~ ,~' :r~~,,,~ -~ :....~..!~.::J ~ ) '\ -----.,,,..,.~ -HAZARDOUS MATERIALS and OCCUPAN<;:Y CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-E • UFCICFC TABLE 8001.15-B SUMMARY· HEAL TH HAZARD MATERIALS -.,. . Isis Phannaceuticals/lbls µtboratory-1891 Rutherford, Carlsbad CA· Control Area 1/Chemical Waste Storag~ STORAGE USE CLOSED USE OPEN Solids Liquid Gas Solid Liquid Gas Solid Liquid Gas Material Lbs Gins Cf •:.: ... Lbs Gins Cf lbs Gins Cf Carcinogens 18.4921 0.7926 Corrosives 8.4535 0.2642 Irritants 58.9881 3.1704 Other Health Hazards 44.7226 2.1136 Sensitizers 5.8118 0.2642 1997/1998 CODES: S1 OCCUPANCY CNTROL AREA CONDITIONS BASED ON THE USE and STORAGE OF HEALTH HAZARD MATERIALS. ' L 114: Class I, II and Ill-A Liquids: Storage and ·uquld transfer operations. Building Is protected throughout by an automatic fire sprinkler system. . SUMMARY· HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 • PAGE 4 -... -· L .... f"i=:~ ... ~ _....,_,_., ............... _, -··1 -· -.... ----r•, ·~ .. ,1_:_ ':J ' ~ ~ . ' " ~---~ ... , HAZARDOUS MATERIALS.and;OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-E-UFC/CFC TABLE 8001.15•8 SUMMARY ,HEALTH H~~ MATERIALS Isis Phannaceutlcals/lbl.s labora~ory -1891 Rutherford, Carlsbad CA -Control Area 1/Chemlcal Waste Storage ~rpt_tj~o,~.~~~f;i~ ~~\~~t:\¾!~~~~t~·:~-:~i-~tH~~s--·?1_;f:~·, :~/.\f/of~:~·.\· · I St()rag, I I unitsJ 1· UC. : ! !Uni~! I UO . ! !Uriits! TOTAL Carcinogens. [LIQUIDS]' AGGREGATE TOTAL Carcinogens [LIQUIDS): . CONSUMER PRODUCTS -1997 UBC TABLE 3-E/UFC TABLE 1001.15-B: 1997 UBC TABLE 3-E/UFC TABLE 1001.15-B EX.EMPT AMOUNTS: 18.4921 Gins 19.2847 . GALLONS UNLIMITED UNLIMITED • WITH SPECIAL CONTROLS Gins 0.7926, Coi'Josivi?si~]~~~~r,;~~~~~-1:._:·,~~ ·, l :~~-~,..:{!£::~i;; l',$.!~;,;j 1~"-~1 t:;··::U<;_'··,I lU!ll.~! ~ TOTAL Corrosives [LIQUIDS] 8.4535 Gins AGGREGATE TOTAL Corrosives [LIQUIDS): 8.7177 GALLONS 1997 UBC TABLE 3-E/UFC TABLE 8001.15-B EXEMP,T AMOUNTS PER CONTROL AREA-H-7 OCCUPANCY REQURIED,ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: 10,000 POUNDS+ 1,000 GALLONS & 1;620 CUBIC FEET STORAGE/AGGREGATE EXEMPT AMOUNT· WITH CABINETS: 20,000 POUNDS+ 2,000 GALLONS & 3,240 CUB)C FEET USE CLOSED EXEMPT AMOUNT: 10,000 POUNDS+ 1,000 GALLONS & 1,620 CUBIC FEET USE OPEN EXEMPT AMOUNT: 2,000 POUNDS + 200 GALLONS' 1997 UFC 8001.14 RETAIL/WHOLESALE STORAGE/DISPLAY• EXEMPT AMOUNTS PER MIS OCCUPANCY CONTROL AREA: 19,500 POUNDS + 1,950 GALLONS 1999 UFC SUPPLEMENT -RETAIL/WHOLESALE STORAGE/DISPLAY -EXEMPT AMOUNTS'PER MIS OCCUPANCY CONTROL AREA: 20,000 POUNDS+ 2,000 GAi.LONS 1999 UFC CUPPLEMENT -S OCCUPANCY STORAGE WITH 8001.14 STORAGE CONDITIONS: 20,000 POUNDS+ 2,000 GALLONS . L 114: Class I, II and Ill-A Liquids: Storage and liquid transfer operations. L 117: Class I, II and Ill-A Liquids: Storage only -no use or transfer conditions Building Is protected throughout by an automatic fire sprinkler system. Gins 0.2642 HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS· ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001-PAGE 5 Gins !Units! Gins· - --.. [-~ =-:-,--..........-~'_.,,._·,-· ' --' -· .-, -·· -· --V"~~~ ........ _. ' _._.! ~ ~ : -.. ~------:_ .. __ ' -HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3.·E • UFC/CFC TABLE 8001.15-B SUMMARY. HEALTH HAZARD MATERIALS Isis Phannaceutlcals/lbis Laboratory-1891 Rutherford, Carlsbad CA· Control Area 1/Chem!cal Waste Storage 'rfl-~P~~:~l~~~~E.½)-:}tf;M~,~--··:-~~~-::·: 1-Tt ~~~~;;0~~F,~:J~~-~·t TOTAL Irritants ILl9UIDS1 AGGREGATE TOTAL Irritants {LIQUIDS): CONSUMER PRODUCTS· 1997 UBC TABLE 3-e/lJFC TABLE 11001.15-B: 1997 UBC TABLE 3-E/UFC TABLE·8001.15-B'EXEMPT AMOUNTS: . STORAGE/AGGREGATE EXEMPT AMOUNT: USE CLOSED EXEMPT AMOUNT: USE OPEN EXEMPT AMOUNT: ·•Ot,b'ef,tt~!.tQ{f.I~j};~~~'~i);::W~,~7h~;t;:,. ·· ~il[~~~'.,;;1=:- TOTAL Other Health Hazards !LIQUIDS) AGGREGATE TOTAL Other Health Hazards (LIQUIDS): CONSUMER PRODUCTS· 1997 UBC TABLE 3-e/lJFC TABLE 11001.15-B: 1997 UBC TABLE. 3-E/UFC'TABl:.E 8001 .15-8 EXEMPT AMOUNTS: STORAGE/AGGREGATE EXEMPT AMOUNT: USE.CLOSED EXEMPT.AMOUNT: USE-OPEN EXEMPT AMOUNT: L 114: Clas,s I, II and Ill-A Liquids: Storage and liquid transfer operations. L 117: Class I, II and Ill-A Liquids: Storage only-no use or transfer conditions Building is protected throughout by an automatic fire sprinkler system. UNLIMITED UNLIMITED UNLIMITED · I S~9i'~g•. I I U!'llis I 58.9881 Gins 62.1585 GALLONS UNLIMITED -WITH SPECIAL CONTROl:.S UNLIMITED UNLIMITED UNLIMITED I .si91)a• ~ I n~rj~., 44.7226 Gl!'!S 46.8362 GALLONS UNLIMITED. WITH SPECIAL CONTROLS t ·uc l !Units!, Gins I -~c;:: .. I lU!tlta I Gins ~ !Urilts! 3.1704 Gins ,. uo. 2.1136 !Units! Gins HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS· ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 • PAGE 6 ::.· ---lllll '<'W" ;;.·-,-~,··-·· -·: ···: -_-·:: -.J ... -:-:--. -~------...... ~--. ~ ·-... •.~. .. - HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS ~BC/CBC TABLE 3-E • UFC/CFC TABLE 8001.15-B SUMMARY. HEAL TH HAZARD MAT!=RIALS Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Carlsbad CA -Control Area 1/Chemical Waste Storage .. ~~~~l~~ijj~ii-:tf~:;~:·~:.~~~9~~,,~,~f:;~·~~-::::::"~·~!t~~:J;~:~~~ TOTAL Sensitizers ILIQUIDSj AGGREGATE'TOTAL Sensitizers [LIQUIDS), CONSUMER PRODUCTS• 1997 UBC TABLE 3-E/UFC TABLE 8001.15-8: 1997 UBC TABLE 3-E/UFC TABLE 8001.15-B EXEMPT AMOUNTS: STORAGE/AGGREGATE EXEMPT AMOUNT: USE CLOSED EXEMPT AMOUNT: USE OPEN !:XEMPT AMOUNT: L 114: Clas.~ I, II and Ill-A Liquids: Storage and liquid transfer operations. L 117: Class I, II and Ill-A Liquids: Storage only -no use or transfer conditions Building is protected throughout by an automatic fire sprinkler system. UNtlMITED UNLIMITED UNLIMITED 1-stotage I I Urtl~ I 5.8118 · Gins 6.0760 GALLONS UNLIMITED -WITH SPECIAL CONTROLS UC' 'J !Units! ! _ UQ Gins o.~~2 HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS· ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 7 !Units! Gins - ·,. 1·· I I I I I I I I I I I I I I I I I I I- 1515 PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODt:S ANALYSIS -IBIS LAB BUILD-OUT ATTACHMENT 1-A2-CONTROL AREA 1 HAZARDOUS MATERIALS INVENTORY ANALYSIS INVENTORY ITEMIZATION-ALPHABETICAL BY MATERIAL NAME 13 November 2001 [Rev. 1] Prepared by T Eriksen-Rattan Associates Inc. 4719 Palm Avenue La Mesa, California Telephone 619.466.6285 FAX 619.466.6233 EMAIL MaryRattan@thecoderesource.com or MaryRattan@covad.net Unless otherwise indicated, the storage amounts the maximum amounts in use and storage at any time, with use amounts <10% of the amounts indicated for storage. Not all inventory items listed will be in use at the same time. -~ ~ r.··---~~ r&'''"-!e"'.sf,'' '''·"''-" t...... ~ t----~.£.111111111111 ~ r{';£$;;-)~n ,....,.:,, -~ -:~: alllJ --,-:·:-·-·:·-~. ~ --- Isis Pharmaceuticals/Ibis Laboratory-1891 Rutherford, Carlsbad CA -Control Area 1/Chemical Was(e Storage: Hazardous Materiais Inventory : tt~\~~~JC?}(i~~tf '~6.;~~-:f~e~~~~!i:7-!'L'.}:·/f:i\\: ){/ '. i~~~~a~,~-;.-_' .... $t~~.~if~~~~ liisi,-0~~ >~~l.1#;}9~b-. >-15Psi LEV ; Locatlpn .. 1 67-64-1 L 100 Aqllone[2.PropanoneJIAutolgnltion: FL1B,IR 5.8118 Gins 0.2642 "Gins Y FLV ControIArea1-L114/l117 869oF; FP 1oF; BP 133oF] [LEL: 2.6%; 2 75-05-8 L 3 75-09-2 L 4 68-12-2 L 5 .123-91-1 L 6 64-17-5 L 7 60-29-7 L UEL: 12.8%] [VD: 2.01;.SG 0.786; VP: 120.I)[FV per Gin: 2020 cl] [RTECS# AL3150000] [HR: H2 F3) >/=50 Acelonitrile [Amldlle Diluent] [FP 42oF; FL 1B; IR, OHH BP 81oCJ [LEL: 3; UEL: 16] (SG Q.786; VD 1.41) (LD50-0 2730 !119/kg; LC50 21,354 ppm] [RTECS# AL7700000) (HR: H2F3J >/=70 Dlchloromelhane [Methylene Chloride] CA, CR, OHH, P65 [Methane Dichloride] [Freon 30] [BP 104oF; FP None} [LD50-0 1800 mg/kg] [RTECS# PA805000J(HR: H3 CORJ 100 Dimethylformamide (N,N-) [DMF] [pH: 8) CA, CL2, IR, OHH [MP -61oC; FP 126oF; BP 153oC) [l.D50- 0 2800 mg/kg; LD50.S 4720 mg/kg; LC50 >18,800 ppm] (RTECS# LQ2100000] [HR: H3 F2) 100 Dloxane (1,4-j(1,4-Dielhylene Oxide] [BP CA, FL 1B, IR, 100oC; FP 54oF] ([EL 2; UEL 22] [SG OHH, P65 1.034; VD 3.049] [l.050-0 4200 mg/kg] (RTECS# JG8225000] (HR: H3 F3] >/=70 Ethanol[EthylAlcohoij[ReagentAlcohoij FL1B, IR, OHH (Molasses Alcohol] (Aromatic Elixir] (ETOH] [Polyamkle Rinse} [FP55.6oF; BP 78.32oC] [LEL: 3.3%; UEL: 19%] (SG 0.789; VD 1.594) (LD50-0,7060 mg/kg; LC50 >10,000 ppm] (RTECS# KQ6300000] [HR: H3 F3) 100 Ethyl Ether (Ether](Diethyl Ether}[FP -40-FL1A, IR, RMP-T2 45oF; BP 94.6oF) (LEL: 1.9; UEL: 36] [MW: 74.122) [SG: 0.713] [VD: 2.565; VP: 8.547 psla) [LD50-0 1215 mg/kg; LC50 103,222] [RTECS# L 15775000] (HR: H2 F4) 5.8118 Gins 0.2642 Gins y FLV Control Area 1-L 114/L 117 8.4535 Gins 0.2642 Gins Control Area 1-L114/Lf17 4.7551 Gins 0.2642 Glris CLV Control Area 1 -L 114/L 117 5.2835 Gins 0.2642 Gins Y . FLV Conlro!Area 1-L114/LH7 ~.6250 Gins 0.2642 Gins Y FLV Control Area 1 -L 114iL 117 5.2835 Gins 0.2642 Gins Y FLV Control Area 1 -L 114/L 117 LEV: Local or gen~ral/area exhaust ventilation required for Class I, fl·and Ill-A Liquids use-open conditions. CLV-Combustlble Liquid Vapor. FLY-Flammable Liquid Vapor. L 114: Clas~ I, II and Ill-A Liquids: Storage and liquid transfer operations. L 117: Class I, II and Ill-A Liquids: Storage only -no use or transfer conditions Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 1 - --.. LIIII ~-~-.,.[jf-1-'=if--.,_ ... "_,, __ ···-.. , .... --~ -· ---.. _ --1:5 ·:~ .... " .. ...., ., __ ; .,,;; ~ ........ ; :.. ·-· .,.:, ... Isis Pharmaceuticals/Ibis Laboratory-1891 Rutherford, Carlsbad CA-Control Area 1/Chem_ical Waste Storage: Hazardous Materials Inventory :~t,~/~~!.i.{~}}1)~:~~tit~ti_:~id~({{iit~ftl)iF(f;;::l~S,!'~);)j~ff~!~~~j;?\St~hlt(~i!:{'.\~~~,~Ri~~}~:~ni.~~)::~bs):.>15~si ._L_E~. Locatl_9n:;,: .. 8 110-54.:3 L 100 Hexane (ii-) (BP 156oF; FP -10oF] [LEL: FL1B, IR 5.2835 Gins 0.2642 Gins Y FLV Control Area 1-L114/L 117 ·1.1; U~L: 7.5; SG 0.655; VD 2.983; MW 86.2] [LD50-0 28710 mg/kg] [RTECS# MN9275000] [HR: H2 F3) 9 67--63-0 L >/=70 lsopropanol [lsopropyl Alcohol) (2-FL1B, IR 3.1701 Gins 0.2642 Gins y FLV Control Area 1.-L 114/L 117 Propanol] [Alcohol] [A870-25 Solder Flux] (425 Thinner) (LDS0-0: 5,840 mg/kg; LD50-S: ~3,000 mg/kg) (FP 53oF; BP 82.5oC] [LEL: 2.5%; UEI.:.: 12%) [SG 2.07~; VD 0.785) [LD50-O 5045 mg/kg) [RTECS# NT8050000] [HR: H2 F3] 10 67-56-1 L >/=50 Methyl Alcohol [Melhanoq [Wood Sealer] FL1B, IR 3.1701 Gins 0.2642 Gins y FLV Control Area 1--L 114/L 117 [Pen Fix] [Reagent Alcohol] (Blue Blox) [MEOH] [FP 52oF; BP 64.7oC/148oF] [LEL: 6%; UEL: 36:5%] [Autoignition: 878oF] [VP 100mm@21.2oCJ [SG 0.791; VD 1.109) [FV per Gin: 1270) [HR: H2F3] 11 110-86-1 , L 100 Pyridine [Azabenzene] [Azlne) [MP -FL 1B, IR, OHH 3;1701 Gins 0.2642 Gins y FLV Control Area 1 -L 1.14/1.117 42oC; BP 115oC; FP 78oF) [SG 0.978; VD 2.72} [LEL 1.8; UEL 12.4] [LD50-O: 891 mg/kg; LD50-S: 9010 mg/kg) [RTCS# UR8400000) [HR: H2 F3J 12 109"99-9 L 100 . Tetrahydrofuran [FP 1oF; BP 69oC) (LEL FL 18, IR, OHH, SN 5.8118 Gins 0.2642 Gins y FLV Control-Area 1-L 114/1:117 . 1.8; UEL 11.8][SG 0.889; VD 2.5] [LD50- 016509/kg; ~C50 21,000 ppm) l (RTECS# LU5950000) [HR: H2 F.3) 13 108-a8-3 L 100 Toluene [Permount] [MP -930; BP FL1B, IR, OHH, 5.8118 Gins 0.2642 Gins y Fl:.V ConlroIArea·1-L114/L117 110oC; FP 40oF] [LEL: 1.2; UEL: 7.1) P65 [VD: 3.188; SG 0.867; VP; 28.53) [LD50- O: 5,000 mg/kg) [FV per Gin: 1250) [RTECS# XS5250000) [HR: H2 F3] LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. L 114: Clas,s I, II and Ill-A Liquids: Storage and liquid transfer operations. L117: Class I, II and Ill-A Liquids: Storage only-no use or transfer conditions Building is protected throughout by an automatic fire sprinkler system: HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 2 - .:., I I I I ·1· I I I I I I I I I I I I I I 1S1S PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS • IBIS LAB BUILD-OUT . ' . ATTACHMENT 1-B -CONTROL AREA 2 HAZARDOUS MATERIALS INVENTORY ANALYSIS _13 November 2001 [Rev. 1] Prepared by T Eriksen-Rattan Associates Inc. 4719 Palm Avenue La Mesa, California Telephone 619.466.6285 FAX 619.466.6233 EMAIL MaryRattan@thecoderesource.com or MaryRattan@covad.net Unless otherwise Indicated, the storage amounts the maximum amounts in use and storage at any time, with use amounts <10% of the amounts indicated for storage. Not all Inventory Items listed will be in use at the same time. I I I· I I I I I I I I I I I I I I I I ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT ATTACHMENT 1-B1 --CONTROL AREA 2 HAZARDOUS MATERIALS INVENTORY ANALYSIS SUMMARY & EXEMPT AMOUNTS 13 November 2001 [Rev. 1] Prepared by T Eriksen-Rattan Associates Inc. 4719 Palm Avenue La Mesa, California Telephone 619.466.6285 FAX 619.466.6233 EMAIL MaryRattan@thecoderesource.com or MaryRattan~covad.net · Unless otherwise indicated, the storage amounts the maximum amounts in use and storage at any time, with use amounts <10% of the amounts indicated for storage. Not all inventory items listed will be in use at the same time. .. <--~w, ,--·-<-~=·-· if~<-·. ,,.,,.._,, . .,.....,-z,·..-,E11111··•"l-·, --· -· ·-r.~ .. -~-· ~----~ , t.LI .. --~ i.t·;:r:· ~.r-!:.. £~£~2~ .i-:~~.J ~-·---..: ~-·'---.. ~ ... __......,. ..... ,; lll!!!!!!!J --~, .. '"---··· :.... :.. -_J ......... - HAZARDOUS MATERIALS arid OCCUPANCY CLASSIFICATION-ANALYSIS. UBC/CBC TABLE 3-D -UFC/CFC TABLES 7902.5-A, 7903.2-B, 8001.15-A SUMMARY· PHYl?ICAL HAZARD MATERIALS lsls.Phannaceutic;;als/l~ls Laboratory-1891 Rutherford, Carlsbad CA-Control Area 2/Labs -STORAGE USE CLOSED Solids · Liquid Gas Solid Liquid Material Lbs Gins Cf. Lbs G_lns Combustible Dusts 2.8854 Combustible.Liquids II 50.2239 Gas Cf Solid Lbs USE OPEN Liquid Gins Gas Cf --------~---------------------------------------------------------------------- Combustible Llq~lds Ill-A 10.2387 , Combustible Liquids 111-B 29.1297 Cryogenic Liquids -Non Hazardous 381.6000 Cryogenic Liquids -Oxidizing 45.0000 Flammable Gases 20.0000 Flammable Liquids I-A 5.0084 Flammable Llquld!! I-B 141.4947 Flammable Liquids I-C 4.0913 Flammable Solids 7.5189 Organic Peroxides Ill 0.0550 Oxidizers 1 4.2684 1997/1998 CODES: B/S1 OCCUPANCY CONDITIONS BASED ON THE USE and STORAGE OF PHYSICAL HAZARD MATERIALS. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. · Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L 115 and.L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustlb\e Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. · Bulld_lng Is protected throughout by-an automatic fire sprinkler system. SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 1 - -.. - ' --i""s-Wi!':-"""""'' ·: . 'r:_, ~ ~~~'.•••_:.; ,, ... , ... --···· --alll1' ' I '• •j' c; .. :;~,$f' _ -~---·---,-•t> _ .. --~-L-·------- HAZARPOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-D -UFC/CFC TABLES 7902.S~A, 7903.2-B, 8001.15-ASUMMARY • PHYSICAL HAZAR~ MATERIALS Isis Pharmaceutlcals/l!>ls Laboratory -1891.Rutherford, Carlsbad CA -Control Area 2/Labs Material Oxidlzers2 Oxldlzers3 Pyrophorlcs Solids Lbs 1.5659 0.0022 STORAGE Liquid Gins 1.1889 --0.1321 --0.4447 Gas Cf Solid Lbs USE CLOSED Liquid Gins Gas Cf So!ld Lbs USE OPEN Liquid Gins Gas Cf ----------------'---------------------------------------··-----Unstable Reactlves 1 2.4412 2.0199 --Unstabfe.Reactlves 2 0.4954 0.3539 Unstable Reactlves 3 0.4404 1.0567 -- Water Reai:tlves 1 21.5974 21.0691 --Water Reactiv_es 2 48.0657 1.5927 --Water Reactlves 3 0.3303 0.7926 1997/1998 CODES: B/S1 OCCUPANCY CONDITIONS BASED ON THE USE and STORAGE OF PHYSICAL HAZARD MATERIALS. Storage Amount = Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116; Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyroph<irlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-.ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 • PAGE 2 - 111111 ----C __ , .• ,,,.,,..,__.,,, .... .,_. . -... , -. _,, ~ :-~-.:~;~~.-.:: .. ~ ....... _! --:_;, .~..u ...-...J .. -·--: __ ··-·--·---··- HAZA~DOUS MATERIALS-and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-D-UFC/CFC TABLES 7902.5-A, 7903.2-B, 8001.15-ASI.IMMARY-PHYSICAL HAZARD,.,.ATERIALS Isis Pharmaceuticals/Ibis Laboratory-1891 Rutherford, Carlsbad CA -Control Area 2/Labs jc<>rn~i!$ll.bl~.:~$~:i/:~· <·: '· .:._-; ·:·:./.-::;-:, ,:.y: . ,-;-.... · '/ =>:. · I I storag~. I I Units I TOTAL Combustible Dusts [SOLIDS) 2.8854 Lbs- HOCCUPANCY NOT APPLICABLE -NO FIRE/EXPLOSION HAZARD POTENTIAL ASSOCIATED WITH USE/STORAGE CONDITIONS. 0£ JUnlts,I ~ !Units! Lbs Lbs ~!>~~~~~1Jqu'E!~i11~;:~~;:}~'.~.~---,~[c:·.~·i:·.:·; . · :1~~-:'ef, TOTAL Combustible Liquids II [LIQUIDS] rsr i....;;J;.,·1 1 l,I' 11s I . _qJ~. ._,t. ('>, u.c; .... , I u.tjtts I I ·. l!O .. I I u~tts I 50.2239 Gins Gins LIQUIDS HAVING FIRE P'OINTS-1997 UBC TABLE·3-D/UFC TABLE 7902.5-AEXEMPT AMOUNTS PER CONTROL AREA: STORAGE & U~E CLOS~!)• H-3 OCCUPANCY REQUIRED ONLY FOR >EXEMPT ~MOUNTS_. . USE OPEN & PRESSURIZED SYSTEMS >15 PSIG • H-2 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: 240.GALLONS STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: 480 GALLONS USE CLOSED EXEMPT AMOUNT: 240 GALLONS USE OPEN EXEMPT AMOUNT: 60 GALLONS LIQUIDS WITHOUT FIRE POINTS -1997 UBC TABLE 30D/UFC TABLE 7902.5-A, 7901.1.1/Exception 9 EXEMPT AM9UNTS PER CONTROL.AREA:' STORAGE: UNLIMITED USE CLOSED EXEMPT AMOUNT: 240 GALLONS USE OPEN EXEMPT AMOUNT: . 60-GALLONS MEDICINES, FOOD,-COSMETICS, ETC.· 1997 UFC 7901. 1.1/EXCEPTION 3: </= SOo/o WATER MISCIBLE FLAMMABLE/COMBUSTIBLE LIQUIDS & CONTAINERS </=4 LITERS: UNLIMITED GROUP M OCCUPANCY· MAXIMUM QUANTITIES PER CONTROL /\REA -1997 UFC TABLE 7902.S·B • COMBINATION 1-B, 1-C, II, Ill-A: CEILINGS </=18' HIGH -</=6' SHELF STORAGE, </=4.5' OTHER STORAGE: 7,500 GALLONS . SPECIAL SPRINKLER SYSTEM PROTECTION: 15,000 GALLONS Building Is protected throughout by an automatic fire sprinkler system. Storage Amount = Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the-same time, with <101/e In use at any time. Control Area 2: Entire building, excludii:tg Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/1.109, Mass Spectrometry Lab/1.110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustlbl~ Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyroph~rlcs: Storage and use-closed system conditions only. SUMMARY-HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 3 Gins - -all alllll L-~r ~-~ -.. , .... ·,-· ----, -··, --~ -'~-~{/ ~qA . ..,..,,.. . _; -',..ii ~ ! -:.-;~--: ____ ----- HAZARDOUS MATERIALS' and.OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-D -UFC/CFC TABLE~ 7902.5-A, 7903.2-B, 8001.15~A SUMMARY -PHY~ICAL HAZARD MATERIALS Isis Phannaceutlcals/lbis Laboratory -1891 Rutherford; Carlsbad CA--Control Area 2/Labs l~bOstlble ·blqulds 1114\'f;'·i~··::~cfj'•~!'e:': ';:-,,,,_._ '' ,:''·,..··-:·,:fr~;\;' ·I , • • ..... •,1.,· ·.' h,11,._ ...... , •• ~.. ~·:·: .... -~ .. l.st~e-I jµnttsj I UC I. tun1tsr I uo I TOTAL Combustible Liguids Ill-A (LIQUIDS] 10.2387 Gins Gins LIQUIDS HAVING FIRE POINTS 0 1997 UBC TABLE 3-0/UFC TABLE 1001.15-A EXEMPT AMOUNTS PER CONTROL AREA: STORAGE & USE CLOSED • H-3 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. USE OPEN & PRESSURliZ .. D SYSTEMS >15 PSIG • H•2 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: 660GALLONS STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: 1,320 GALLONS USE CLOSED EXEMPT AMOUNT: 660GALLONS USE OPEN EXEMPT AMOUNT: ~ 160 GALLONS LIQUIDS WITHOUT FIRE POINTS -1997 UBC TABLE 30D/UFC TABLE 7902.5-A, 7901.1.1/Exception 9 EXEMPT AMOUNTS PER CONTROLAREA: 'STORAGE: UNLIMITED USE CLOSED EXEMPT AMOUNT: 660GALLONS USE OPEN EXEMPT AMOUNT: MEDiCINES,,FOQD, COSMETICS, ETC:.· 1997 UFC: 7901.1.1~CEPTION 3: 160GALLONS <I• 50% WATER MISCIBLE FLAMMABLE/COMBUSTIBLE LIQUIDS & CONTAINERS </•4 LITERS: UNLIMITED GROUP M OCCUPANCY· MAXIMUM QUANTITIES PER CONTROL AREA -1997 UFC TABLE 7902.R • COMBINATION I-B, I-C, II, Ill-A: CEILINGS </=18' HIGH -</=6' SHELF STORAGE, </=4.5' OTHER STORAGE: 7,500 GALLONS Sf'ECIAl,,.SPRINKLER SYSTEM PROTECTION: 15,000 GALLONS ~l;ius~bl~il:,tq~li:!f'l.llf.Q€if.~\:,'~r,(f7f{~;;.~:-,!~·:;01:!l.'·,:;r;:: 1-~t~I jun~! l>'UC· ·I !U.nlts! I·: uo I TOTAL Combustible Llguids 111-B (LIQUIDS] 29.1297 Gins Gins ' -' - 1997 UBC TABLE 3-D/UFC TAEiLE 8001.15-A EXEMPT AMOUNTS PER CONTROL AREA• H OCCUPANCY NOT REQUIRED IN SPRINKLERED BUILDING. STORAGE/AGGREGATE EXEMPTAMOUNT -NO CABINETS: UNLIMITED STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: UNLIMITED USE CLOSED EXEMPT AMOUNT: UNLIMITED USE OPEN EXEMPT AMOUNT: UNLIMITED MEDICINES, FOOD, COSMETICS, ETC.• 1997 UFC 7901.1/EXCEPTION 3 • </= 50% WATER MISCIBLE FLAMMABLE/COMBUSTIBLE LIQUIDS & CONTAINERS </=4 LITERS: UNLIMITED Building Is protected throughout by an automatic fire sprinkler system. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/l 101, Refrlgerator/L 103 New Haz Mat Lo~tions: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. .. SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANAL YSiS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 • PAGE 4 !Units! Gins lUnlts! Gins - .. ' - . ~ w-v:·:--'::ft.l'l ---. t:.111111111111 ~ Y.:. •• -~. ·1w1,,,--P-1-W-'J.e .... ,.,,.,,,. .,. n--· , -:-,, __ , -·~ -------·---~ ~~ .. ~:if· :.'..:s:r.~ , ..... _, __ } .,_'"'i ~ ' _ _ \..._ L. , ··-. ~ ..... , HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-D • UFC/CFC TABLES 7~2.5-A, 7903.2-B, 8001.15-ASUMMARY • PHYSICAL HAZARD MATERIALS lgls Pha1111a\:euticals/lbis Laboratory -1891 Rutherford, Carlsbad CA· Control Area 2/Labs jcryogeP.lci~1.4~~~-~:N9fi:tf@if!f~.'.:~~~~~;-,'.-~:~:~.~~ ~-~·.:::.::, l r ~t~.l'.89~ I I Units I I· UC !Units! ~ !UnJts! TOTAL Cryogenic Liquids -Non Hazardous (CRYOGENICS) 381.6000 · Gins Gins H OCCUPANCY NOT APPLICABLE TO NONHAZRDOUS MATERIALS -UNLIMITEp AMOUNTS. · c~ri.!i::~Ji:i.11.~;~;Q~lz.t~o'.f.i;1;w~~1:f~\Ef .:.; :::r-·J ,'~<~,t:F~ <.:r: · TOTAL Cryogenic: Liquids -Oxidizing !CRYOGENICS} 1st· ... ,, 1u·11sj ,,J?-!.&ge.. rt . 1 , -u~· . 1 1u.n1tsl r~ .. t,1q' 45,0000 Gins Gins 1997 UBC TABLE 3-D/UFt TABLE i001.15-A EXEMPT AMOUNTS PER CONTROL AREA• H-3 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT· NO CABINETS: 45 GALLONS STORAGE/AGGREGATE EXEMPT AMOUNT· WITH CABINETS: 45 GALLONS USE CLOSED EXEMPT AMOUNT: 45 GALLONS USE OPEN EXEMPT AMOUNT: 10 GALLONS Building is protected throughout by an automatic fire sprinkler system. Storage Amount = Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire buildlng, excluding Chemlcal Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L103, Magnet Room/L109, Mass Spectrometry Lab/L110, Robotics Lab/L101, Refrigerator/L103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyroph~rlcs: Storage and use-closed system conditions only. . SUMMARY-HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 5 Gins !Units! Gins - L.. __ j -.. L __ il';,,.$/l ,,,: -,:_ ... ; --·1 _,;; --'. -!:'..{:'$l -~:,.!."~-=' ·--· -,··· .-,r,._,V ~-_.,. ·--,,_ C--, --·- . HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS u·ec,cec TABLE 3-0 • UFC/CFC TABLES 7902.S<A, 7903.2-B, 8001.15-ASUMMARY • PHYSICAL HAZARD MATERIALS lsls Phannaceutlcals/lbls Laboratory. 1891 Rutherford, Carlsbad ~A· .Control Area 2/Labs !Flam· m'able'"G"'""s' .,,,,,,.;;,,,,,,._,1j .. ,,-e,.;.•,< .. ,,;~,, .. ,,, .... , .. ", .. ;p'.,,• I . , ... " ,, , , ~G~!"-: ;~~i~:::'"/,.S'.}f,·~.!:t· .~·-,:C~~:';"~i;1,fi:·/:" ~-=.-~ • _; :~j_;..~: ·~-~~-. •' .' r Stori!ge-1 I un,ts 1 Q£ !Units! uo· -:·-. !Units! TOTAL Flammable Gases !LIQUEFIED GASES) 20.0000 Cf Cf, Cf. 1997 UBC TABLE 3-0/UFC TABLE 8001.15-A EXEMPT AMOUNTS PER CONTROL AREA • H-2 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT· NO CABINETS: 1,500 CUBIC FEET & 30 GALLONS STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: 3,000 CUBIC FEET &-60 GALLONS USE CLOSED EXEMPT AMOUNT: 1,500 CUBIC FEET & 30 GALLONS USE OPEN EXEMPT AMOUNT: NOT APPLICABLE !Flam~~lc,.,!Jq!JJ~lf,!~~;:.:~:~;;1'~-.[.'.~':i,1~_~:-);.:,,,. ·. ,:::.-,'--.,, '.,,, ·;\' ·I TOTAL Flammable Liquids I-A !LIQUIDS) I · stor.ue'j I ~-"Its: I L .:' UC :--l ju~ltsj !-· I.JO' . l. I Units I 5.0084 Gins Gins Gins LIQUIDS HAVING FIRE POINTS -1997 UBC TABLE 3-D/UFC TABLE 7902.5-a EXEMPT AMOUNTS PER CONTROL AREA: STORAGE & U!lE CLOSED • H~ OCCUPANCY_ REgUl~ED ONLY FOR >EXEMPT AMOUNTS. . USE·OPEN & PRESSURIZED SYSTEMS >15 PSIG • H-2 OCCUPANCY REQUIRED ONLY FOR">EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: . 60 GALLONS STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: 120 GALLONS USE CLOSED EXEMPT AMOUNT: 60 GALLONS USE OPEN EXEMPT AMOUNT: 20 GALLONS LIQUIDS WITHOUT FIRE POINTS -1991 UBCTABLE 30D/UFC TABLE 7902.5-A, 7901.1.1/E>tception 9 EXEMPT AMOUNTS PER CONTROL AREA: STORAGE: UNLIMITED USE CLOSED EXEMPT AMOUNT: 60 GALLONS USE OPEN EXEMPT AMOUNT: 20 GALLONS· MEDICINES,fO9D, COSMETICS, ETC. -1997 UFC 7901.1/EXCEPTION 3: </= 50% WATER MISCIBLE FLAMMABLE/COMBUSTIBLE LIQUIDS & CONTAINERS </=4 LITERS: UNLIMITED GROUP M OCCUPANCY· MAXIMUM QUANTITIES PER CONTROL AREA• 1997 UFC TABLE 7902,5-B: 80 GALLONS Building is protected throughout by an automatic fire sprinkler system. Storage Amount= Maxlmumltotal amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% in use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/1.110, Robotics Lab/L 101, Refrlgerator/L 103 New Hilz Mat Locations: BSL-2 Labs/L115 and L116, Equip LabslL120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. PyrophC>rics: Storage and use-closed system conditions only. SUMMARY· HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS· ERIKSEN-RATTAN ASSOCIATES INC.· 11/13/2001 -PAGE 6 - . L __ _ ._ -c--~~~~r-,;,. , ___ .;;,-· . ; -·) ---, ---·;1 • -•,:n.,_,"}la .... -~. ~... .d ~ -: -~--~---·····-. -HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS USC/CBC TABLE 3-D-UFC/CFC TABLES 7902:5-A, 7903.2-B, 8001.15-A Sl,.IM~ARY -PHYSICAL HAZARD MATERIALS Isis Phannaceutlcalsilbis Laboratory -1891 Rutherford, Carlsbad CA -Control.Area 2/Labs lf.l_~rn~r;i"-!~ t!_q\-!l~sJ:~:;;f~'3.f:;;c;;<J:4•q;p£:)?~~?: :';t.:.t~~~:.l TOTAL Flammable Liquids 1-B (LIQUIDS) LIQUIDS HAVING FIRE POINTS• 1997 UBC TABLE 3-D/UFC TABLE 7902.5-a EXEMPT AMOUNTS PER CONTROL AREA: STORAGE & USE CLOSED •'H-3 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. USE OPEN & PRESSURIZED SYSTEMS >15 PSIG • H•2.0CCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. . l sto~ge l I Unlb I 141.4941 Gins STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: 120 GALLONS STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: 240 GALLONS USE CLOSED EXEMPT AMOUNT: 120 GALLONS USE OPEN EXEMPT AMOUNT: -30 GALLONS LIQUIDS WITHQUT FIRE POINTS -1997 UBC TABLE 30D/UFC TABLE 7902.5-A, 7901·.1.1/Exception 9 EXEMPT AMOUNTS PER CONTROL AREA: STORAGE: UNLIMITED USE CLOSED EXEMPT AMOUNT: 120 GALLONS USE OPEN EXEMPT AMOUNT:· 30 GALLONS MEDICINES, FOOD, COSMETICS, ETC. • 1997 UFC 7901.1/EXCEPTION 3: <I• 50% WATER MISCIBLE FLAMMABLE/COMBUSTIBLE LIQUIDS & CONTAINERS </ .. 4 LITERS: UNLIMITED GROUP M OCCUPANCY. MAXIMUM QUANTITIES PER CONTROL AREA· UFC TABLE 7902.5-B. • COMBINATION 1-B, 1-C, II, Ill-A: CEILINGS </=18' HIGH -</=6' SHELF STORAGE, </=4.5' OTHER STORAGE: 7,500 GALLONS SPECIAL SPRINKLER SYSTEM P~OTECTION: 15,000 GALLOf-lS ~ !Units! UO· Gins !f.l,m.~~~~f~~J~O-~J. :w~~'R~4fe;)'.::{;: r;:~,J;:. ·/~~-.-;_:,-::'<; I I ~~9.rage·;-1 I ~n~ I 1-."'·.UC · 1 jl!n!~I ·uo - TOTAL Flammable Liquids 1-C ILIQUIDSJ 4.0913 Gins Gins LIQUIDS HAVING FIRE POINTS· 1997 UBC TABLE 3-D/UFC TABLE 7902.5-A EXEMPT AMOUNTS PER CONTROL AREA: STORAGE. & USE CLOSED-H-3 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. . USE OPEN & PRESSURIZED SYSTEMS >15 PSIG • H-2 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: 180 GALl:.ONS STORAGE/AGGREGATE EXEMPT AMOUNT -WiTH CABINETS: 360 GALLONS USE CLOSED EXEMPT AMOUNT: · . 180 GALLONS USE OPEN EXEMPT AMOUNT: . 40 GALLONS LIQUIDS WITHOUT FIRE POINTS·-1997 UBC TABLE 30D/UFCTABLE 7902.5-A, 7901.1.1/Exceptlon 9 EXEMPT AMOUNTS PER-CONTROL AREA: STORAGE: . UNLIMiTED 'USE CLOSED EXEMPT AMOUNT: 180 GALLONS USE OPEN.EXEMPT AMOUNT: 40 GALLONS MEDICINES, FOOD, COSMETICS, ETC. -1997 UFC 7901.1/EXCEPTION 3: </• 50% WATER MISCIBLE FLAMMABLE/COMBUSTIBLE LIQUIDS & CONTAINERS </=4 LITERS: UNLIMITED GROUP M OCCUPANCY• MAX_IMUM QUANTITIES PER CONTROL AREA· UFC TABLE 7902.5-B • COMBINATION 1-B, 1-C, II, Ill.A: CEILINGS </=18' HIGH -</=6' SHELF STORAGE, </=4.5' OTHER STORAGE: 7,500 GALLONS SPECIAL SPRINKLER SYSTEM PROTECTION: . 15,000 GALLONS Bulldlng Is pr~tected throughout by an automatic fire sprinkler system. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire-or explosion potential. Pyrophorics: Storage and use-closed system conditions only. -. SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 7 jun1tsj Gins !Units! Gins 'i. .... L~ ,,.,.,_ [. -e,:<<,....."t'?'·'-.,~·....,,&·"i'·-'·'····-•' -··· -··, .~ (-_:___ ~ ~;~~~~~ .. __., • ··----: --.,.;...,..! . ~dJ HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-D • UFC/CFC TABLES 7902.5-A, 7903.2-B, 80Q1.15-ASUMMARY • PHYSICAL HAZARD MATERIALS Isis Phannaceuticals/lbis !,.aboratory-·1.891 Rutherford, Carlsbad CA -Control.Area 2/Labs ~ ~- !Flam.~!;>!~ ~<>Rd.~;:'ii_,;,;:-.1:· -';';f-';-,X::\/~·'." :,:·. :·· · .,.~-. ·, :.;~ _., . ·.; · I Siotage I . I Units ! TOTAL Flammable Solids [SOLIDS) 7.5189 Lbs 1997 UBC TABLE 3-0/UFC TABLE 8001.15-A EXEMPT AMOUNTS PER CONTROL AREA· H-3 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS, STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: STORAGE/AGGREGATE EXEMPT AMOUNT· WITH CABINETS: 250POUNDS 500POUNDS -: C§ USE CLOSED EXEMPT AMOUNT: . USE.OPEN EXEMPT AMOUNT: NOT APPLICABLE· NO FIRE/EXPLOSION HAZARD POTENTIAL NOT APPLICABLE • NO FIRE/EXPLOSION HAZARD POTENTIAi,. !OilJ~"1~: J?.~~~· !IP::~'/_: H,';:;~/~';· :.~. :.,,, .. · -:: .. : ··. · ...... : :. ( .: :: ~· .. :: ,;1 I .~t~e:: I j.un~ I ·uc TOTAL Organic Peroxides Ill [SOLIDS] 0.0550 Lbs 1997 UBC TABLE 3-D/UF.C TABLE 8001.15-A EXEMPT AMOUNTS PER CONTROL AREA• H-3 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS •. . STORAGE/AGGREGATE.EXEMPT1\MOUNT -NO CABINETS: 250 POUNDS+ 25·GALLONS STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: 500 POUNDS+ 50 GALLONS USE CLOSED EXEMPT AMOUNT: 250 POUNDS + 25 GALLONS USE OPEN EXEMPT AMOUNT: 50 POUNDS + 5 GALLONS 1997 UBC TABLE 3-G/UFC TABLE 8003.1-B • MAXIMUM AMOUNT PER BUILDING WITHOUT DETACHED STORAGE: 50 TONS Building Is protected throughout by an automatic fire sprinkler system. -· f.- !Units! Lbs · 1 (.!nits.I Lbs Storage Amount = Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% in use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL·2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyroph!)ri~: Storage and use-closed system conditions only. :: .• : .. -........ - ~ jun1tsj Lbs uo !Units! Lbs SUMMARY· HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 • PAGE 8 - -} -- ;-~~ ~f ~~ f~'f:1' ,, ... , ...... ·-,_ .,, -·;'.\ _, ._ ~ .. ,:-:, g-· ~~{fj; ~.,..,_.. _____ _; __ ..; ..... ~ ~ ,_ -~· HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-0 • UFC/CFC TABLES 7902.5-A, 7903.2-B, 8001.15-A SUM.MARY. PHYSICAL HAZARD MATERIALS Isis Pharmaceuticals/Ibis Laboratory • 1891 ·Rutherford, Carlsbad CA • Control Area 2/Labs joxiif!zel'.s·}'!. :: .. ,· · '·::"< (:~·,. · ..... : \.· .. , :<;:<:., .; :::··/'i TOTAL Oxidizers.1 (SOLIDS] J S~orage ! ! Units ! 4.2684 Lbs . ' 1997 UBC TABLE 3-0/UFC TABLE 8001.15-A EXEMP'I' AMOUNTS PER CONTROL AREA• H-3 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: 8,000 POUNDS + 800 GALLONS STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: 16,000 POUNDS+ 1,600 GAl:.LONS USE CLOSED EXEMPT AMOUNT: . 8,000 POUNDS + 800 GALLONS USE OPEN EXEMPT AMOUNT: 2,000 POUNDS + 200 GALLONS UC 1997 UFC 8001.14 RETAIL/WHOLESALE STORAGE/DISPLAY. EXEMPT AMOUNTS PER M/S OCCUPANCY CONTROL AREA~ 36,000 POUNDS+ 3,600 GALLONS 1999 UFC SUPPLEMENT. RETAiNtwHOLESALE STORAGE/DISPLAY -EXEMPT AMOUNTS PER MIS OCCUPANCY CONTROL AREA: SAME AS 1997 UFC 1999 UFC SUPPLEMENT· S OCCUPANCY STORAGE WITH 8001.14 STORAGE CONDITIONS: 36,000 POUND$ + 3,600 GALLONS -- !Units! Lbs jo.x1dJz~it~;;:: :,:_. .~>;;_: ,~; .. ,_rr~,2:\~~?,;;.k. .. ,._,-: ;::·: · .:~ :. :-:: ·:><··· .. _.I TOTAL Oxidliers,2 !SOLIDS] j· St!>!'liil• :l I U.nlts I l : ;Uc.·. l !Units! TOTAL Oxidizers 2 !LIQUIDS] 1.5659 1.188!:! Lbs Gin!! 1997 UBC TABLE "·D/UFC TABLE 8001.15'-A.EXEMPT AMOUNTS PER CONTROL AREA· H-3 OCCUPANCY REQUIRED·ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: 500 POUNDS+ 50 GALLONS STORAGE/AGGREGATE.EXEMPT AMOUNT -WITH CABINETS: 1,000 POUNDS+ 100 GALLONS USE CLOSED EXEMPT AMOUNT: . 500 POUNDS + 50 GALLONS USE OPEN EXEMPT AMOUNT: 100 POUNDS+ 10 GALLONS 1997 UFC 8,001.14 RETAIL/WHOLESALE STORAGE/DISPLAY· EXEMPT AMOUNTS PER MIS OCCUPANCY CONTROL AREA: 4,500 POUNDS+ 450 GALLONS 1999 UFC SUPPLEMENT -RETAIL/WHOLESALE STORAGE/DISPLAY -EXEMPT AMOUNTS PER MIS OCCUPANCY CONTROL AREA: SAME AS 1997 UFC 1997 UBC TABLE 3-G/UFC 8003.1-B. MAXIMUM AMOUNT PER BUILDING WITHOUT DETACHED STORAGE: 2,000 TONS . 1999 UFC SUPPLEMENT -S OCCUPANCY STORAGE WITH 8001.14 STORAGE CONDITIONS: 4,500 POUNDS + 450 GALLONS Building Is protected throughout by an automatic fire sprinkler system. Lbs Gins Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10o/, in use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L103, Magnet Room/L109, Mass Spectrometry lab/L110, Robotics Lab/L101, Refrigerator/L103 New Haz Mat Locations: BSL-2 Labs/L 115 and L 116, Equip labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and-conditions create a fire or explosion potential. Pyroph~rlcs: Storage and use-closed system conditions only. =--.. -.. ···- ~ jun1tsj Lbs UC>-· l !Uni~! Lbs Gins SUMMARY· HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS· ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001-PAGE 9 - _, ---( ... IF -tr!• f·-::-. ------. -• --~ ... ·: ~dl':"-=alllllllll,.............. _., ... J ':u.,:;J 'i.,:,Mt ~ -; -~-· ___ : ____ _ HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TAB!.,~ 3-D--UFC/CFC TABLES 7902.5-A, 7903.2-B, 8001.1!j-ASUMMARY. PHYSICAL HAZARD MATERIALS Isis Phannl!ceuticals/lbls Laboratory· 1891 Rutherford, Carlsbad CA· Control Area 2/Labs- !9xldize~~3 ,, 1:f::'~'~-:"'),i-'-. -:< · .--'.:.--: -':,<:_·_:_ .;-.>;..---.·.-. :_;q ! Sto~ge I !Units!· UC TOTAL Oxidizers 3 (LIO!.!IDS) 0.1321 Gins 1997 UBC TABLE 3-D/UFC TABLE 8001.15-A EXEMPT AMOUNTS PER CONTROL AREA· H-2 OCCUPANCY REQUIRED. ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: . 20 POUNDS+ 2 GALLONS STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: 40 POUNDS+ 4 GALLONS USE CLOSED-EXEMPT AMOUNT: 4 POUNDS+ 0.40 GALLON USE OPEN EXEMPT AMOUNT: 4 POUNDS + 0,40 GALLON . 1997 UFC 8001.14 RETAIL/WHOLESALE STORAGE/DISPLAY· EXEMPT AMOUNTS PER M/S OCCUPANC:Y CONTROL AREA: 2,250 POUNDS+ 225 GALLONS 1999 UFCSUPPLEMENT -RETAIL/WHOLESALE STORG/OISPLAY -EXEMPT AMOUNTS PER MIS OCCUPANCY CONTROL AREA: 2,300 POUNDS+ 230 GALLONS 1997 UBC TABLE 3-G/UFC TABLE 8003.1-8 • MAXIMUM AMOUNT PER BUILDING WITHOUT DETACHED STORAGE: 1,200 TONS 1999 UFC SUPPLEMENT -S OCCUPANCY STORAGE WITH 8001.14 STORAGE; COND,ITIONS: 2,300 POUNDS + 230 GALLONS !1.Jnlts! uo ·Gins !1:"yrop~(Jrl~:~s;'.;~:1>:f:;:~-.r,~~,t-~;1rk.:~ -~~f.~ ':/'.~\, . .-· .. _., :.: ':::.: . .-~::,. I . '' . I st~ge.'j !1.Jn~I I' ·. UC · .1 l 1,JriltS, 1 L-' uo TOTAL Pyrophorics (SOLIDS) TOTAL Pyrophorics (LIQUIDS) 1997 UBC· TABLE 3-D/UFC TABLE 8001.15-A EXEMPT AMOUNTS PER CONTROL AREA SOLIDS & LIQUIDS· H-3 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. GASES· H-2.0CCUPANCY REQUIRED.ONLY FOR >EXEMPT AMOUNTS. 0.0022 0.4447 Lbs Gins STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: 4 POUNDS+ 0.40 GALLON & 50 CUBIC FEET STORA~E/AGGREGATE EXEMPT AMOUNT, WITH CABINETS: B POUNDS+ 0.80 GALLON & 1\)0 CUBIC FEET Lbs Gins USE CLOSED EXEMPT AMOUNT: 1 POUND+ 0.1 <,;ALLON & 10 CUBIC FEET [20 CUBIC FEET IF IN.CABINETS) USE OPEN EXEMPT AMOUNT: NONE 1997 UBC TABLE 3-G/UFC TABLE 8003.1-8 • MAXIMUM AMOUNT PER BUILDING WITHOUT DETACHED STORAGE: GASES -2,000 CUBIC FEET Building is protected throughout by an automatic fire sprinkler system. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115_and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyroph~rics: Storage and use-closed system conditions only. SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 • PAGE 10 !'Urilts! Gins !Units! Lbs Gins - ... ---, , .. ~ •P-·wr,.;· . \ -~ -·-t·-··-: ···,-··:·, •j -··· _ _,..., ....... _., ___ l_.._,, ~ -;, _, -· 1 ~ -·· -·-f -~-·--:. ..... -HAZARDOUS.MATERIALS and QCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-D • UFC/CFC TABLES 7902.5-'A, 7903.2-B, 8001.15-A SUMMARY -PHYSICAL.HAZARD MATl::RIALS Isis Pharmaceuticals/Ibis Laboratory-~891 Rutherford, Carlsbad CA -Control Area 2/Labs IU '"'!;ll"''R' . ...,.. •. ··1· ,, ... , .. _.; .... ,,,_,, .• , ..... ,,, ... , .... · ..... " ., ·1 ns... .. ea ... uves ··::. -:, .... :,. ':'.,~,--~-:·· ··.-,;~,-~ .. ,,~ .. ' ···.,,. ·: . ,_ ••• ,._ _. ,,. , • ... , ...... 1-',r,.,.., •• ~ ...... , , , ~ ........... ~ ••• , ,-:..· • , ! St9rage I I Units I -~ jur11ts! l . uo l !Units! TOT AL Unstable Reaclives 1 (SOLIDS]. 2.441Z Lbs Lbs Lbs TOTAL Unstable Reaclives 1 (LIQUIDS) 2.0199 Gins Gins 1997 UBC TABLE 3-0/UFC TABLE 8001.15-A EXEMPT AMOUNTS PER CONTROL AREA-H-3 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: UNLIMITED STORAGE/AGGREGATE EXEMPT AMOUNT O WITH CABINETS: UNLIMITED USE CLOSED EXEMPT AMOUNT: UNLIMITED USE OPEN EXEMPT AMOUNT: UNLIMITED NOTE: PUBLICATION ERROR-ERRATA TO UBC & UFC TO CORRECT GASES TO UNLIMITED. Building Is protected throughout by an automatic fire sprinkler system. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10°/o in use at any time. Control Area 2: Entire building,.excludlng Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat-Locations: Cold Room/L 103, Magn~t Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dus~: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. -SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 11 Gins -· -\ -.. ,-·····-,----,;"(". .. ] I.;. ·-91·--·-~--u:::~-r::~_ .. , __ ;...__~ ..... :; llliiaJ ... ~ .. ------------HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANAL YSI~ UBC/CBCTABLI; 3-Q-UFC/CFC TABLES 7902.5-A, 7903:2-B, 8001.15-ASUMMARY-PHYSICAL H~D MATERIALS Isis Pharmai:eutlcals/lbls. Laboratory -1891 Rutherford, Carlsbad CA -Control Area 2/Labs juristabl~--~eac!)v~ ~ '',~J,.;f;;:: '\·-·': -~ .;i:.'(· ~-~ . '· :_ '.· '-. ,: : ·-:::, ... _·.' l-. . . " l Storage_ j I Units I !!:J I Units I -! UO l ! l!nlts I TOTAL ynstable Reactlves 2 {SOLIDS] 0.4954 Lt>s TOTAL Unstable Reactlves 2 !LIQUIDS] 0.3539 Gins 1997 UBC TABLE 3-D/UFC TABLE 8001.15-A EXEMPT AMOUNTS PER CONTROL AREA· H-3 OCCUPANCY REQUIRED'ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: 100 POUNDS+ 10 GALLONS & 1,500 CUBIC FEET STORAGE/AGGREGATE EXEMPT AMOUNT --WITH CABINETS: 200 POUNDS+ 20 GALLONS & 3,000 CUBIC FEET USE CLOSED EXEMPT AMOUNT: 100 POUNDS+ 10 GALLONS & 1,500 CUBIC FEET USE OPEN EXEMPT AMOUNT: 20 POUNDS + 2 GALLONS 1997 UFC 8001.14.RETAIUWHOLESALE STORAGE/DISPLAY. EXEMPT AMOUNTS PERM/S OCCUPANCY CONTROL AREA: 900 POUNDS+ 90 GALLONS 1999 UFC SUPPLEMENT -RETAIL/WHOLESALE STORAGE/DISPLAY --EXEMPT AMOUNTS PER MIS OCCUPANCY CONTROL AREA: 1,300 POUNDS+ 230 GALLONS 1997 UBC TABLE 3-G/UFC TABLE 8003.1-B • MAXIMUM AMOUNT PER BUILDING WITHOUT DETACHED STORAGE: GASES -10,000 CUBIC FEET LIQUiDS & SOLIDS -25 TONS 1999 _UFC SUPPLEMENT -GROUPS OCCUPANCY STORAGE WITH 8001:14 STORAGE.CONDITIONS: 2,300 POUNDS+ 230 GALLONS _ __,. Building is protected throughout by an automatic fire sprinkler system. Lbs Lbs qIns Gins Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10o/o In use at anytime. Control Area 2: Entire bullding,·excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, m;mufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. ' SUMMARY· HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 12 - ---, .. i_,:: ------~_;IIIL-3 -",.:; lllllJ -J HAZARDOUS MATERIALS arid-OCCUPANCY CLASSIFICATION ANALYSIS UBClC~C TABLE 3-D • UFC/CFC TABLES 7902.5-A, 7903.2-B, 8001·.15-ASUMMARY -PHYSICAL HAZARD MATERIALS Isis Pharmaceuticals/Ibis Laboratory-1891 ~utherford, Carlsbad CA-Control Area 2/Labs .. -~- juns~Ql~~Rea_ctives·~~-?:·· . .:,~r:-;·:-->(-'::.·'i'·. ·::·,-..... ·:·:i\-:.·: I j ~tora_g~ I I U!lits I . UC !U"its! ~ -. TOTAL Unstable Reactlves 3 (SOLIDS] 0.4404 Lbs TOTAL Unstable Reactlves 3 !LIQUIDS) 1997 UBC TABLE 3-0/UFC TABLE 8001.15-A EXEMPT AMOUNTS PER CONTROL AREA. NONDETONATABLE • H-2 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. DETONATABLE • H•1 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. 1.0567 Gins STORAGE/AGGREGATE EXEMPT AMOUNT· NO CABINETS: 10 POUNDS-+ 1 GALLON & 100 CUBIC FEET STORAGE/AGGREGATE·EXEMPT AMOUNT -WITH CABINETS: 20 POUNDS+ 2 GALLONS & 200 CUBIC FEET USE CLOSED EXEMPT AMOUNT: 2 POUNDS + 0.20 GALLON & 20 CUBIC FEET USE OPEN EXEMPT AMOUNT: 2 POUNDS + 0.20 GALLON . 1997 UFC 8001.14 RETAIUWHOLESALE STORAGE/DISPLAY·· EXEMPT AMOUNTS PER MIS OCCUPANCY CONTROL AREA: 1', 125 POUNDS + 112.5 GALLONS 1997 uec TABLE 3-G/UFC 8003.1-8 -MAXIMUM.AMOUNTS PER BUILDING WITHOUT DETACHED STORAGE: GASES -2,000 CUBIC FEET . . LIQUIDS & SOLIDS • 1 TON 1999 UFC SUPPLEMENT -S OCCUPANCY STORAGE WITH 8001.14 STORAGE CONDITIONS: 1. 100 POUNDS + 110 GALLONS Building Is protected throughout by an automatic fire sprinkler system. Lb!i . Gins Storage Amount =: Maximum/total amount in use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% in use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. -SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 13 ~-: .... - (Units! Lbs Gins - ----;·-.,.,,_ """''-"~~-rr-,M--·,.,· ,..._ ·-· ··-· ·, -· ,, ---· -L.... ~ ~ ~~ t~~ -' ~.1-~~~-----.. ; ~--_; ~~~ ' .;.J ___ _} ; -·-----.·.- HAZARDOUS Mf.TERIALS and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TA!;iLE 3-D • UFC/CFC TABLES 7902;5.A, 7903.2-B, 8001.15-A SUMMARY -PHYSICAL HAZARD .MATERIALS Isis Phannaceutlcals/lbls Laboratory-1891· Rutherford, Carlsbad CA-Control Area 2/Labs !W~ter.·.~,~ctiY,eS ~ :-[~'5r:·'.·~:·~(:;:,'f'/t:J:~{,:i,;·-· ·;,,'.,·,><'' .. ::.'· ! ! S~oi'age I j 1,1n~s !· TOTAL Water Reactives 1 [SOLIDS) TOTAL Water Reaclives 1 {LIQUIDS) 21.5974 21.0691 Lbs Gl11s 1997 UBC TABLE 3-D/UFC TABLE 8001.15-A EXEMPT AMOUNTS PER CONTROL AREA; H OCCUPANCY·NOT REQUIRED IN SPRINKLERED BUILDING. STORAGE/AGGREGATE EXEMPT AMOUNT· NO CABINETS: . . UNLIMITED STORAGE/AGGREGATE EXEMPT AMOUNT-WITH CABINETS: UNLIMITED USE CLOSED·EXEMPT AMOUNT: UNLIMITED USE OPEN EXEMPT AMOUNT: UNLIMITED Building Is protected throughout by an automatic fire sprinkler s~tem. UC. !Unit~! (:§ Lbs Gins Storage Amount = Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms l 114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyroph~rlcs: Storage and use-closed system conditions only. SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 14 jun1~j Lbs (31ns - -1 _, --· f-qa· ·wF) ..... ____ ., .......... '. ... ,, ~ . =~ y,,,--_;---.:-_ _, ~~.J -~;---HAZARDOUS MATERIALS and OCCUPANCY.CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-D • UFC/CFC TABLES 7902.5-A, 7903.2-B, 8001.15-ASUMMARY • PHYSICAL HAZARD MATERIALS lsls·Phannaceuticals/lbis Laboratory-1891 Ruther(ord, Carlsbad CA.-C~ntrol.Area 2/Labs lwater~E!~~~s:.~,:.!-z_;_ .. :\ .-::: .. .:.-:,>. "::··· : .: :-.'.d~.-,i·.i:: I ! Sto~ge I junl.~sl I TOTAL Water Reactives 2 (SOLIDS) 48.0657 Lbs TOT Al Water Reactives 2 (LIQUIDS) 1.5927 Gins 1997 UBC TABLE 3-0/UFC TABLE 8001.15-A EXEMPT AMOUNTS PER CONTROL AREA• H•3 OCCUPANCY-REQUIRED ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: 100 POUNDS+ 10 GALLONS STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: 200 POUNDS+ 20 GALLONS USE CLOSED EXEMPT AMOUNT: 100 POUNDS+ 1() GALLONS USE OPEN EXEMPT AMOUNT: 20 POUNDS + 2 GALLONS 1997 UFC·8001.14 RETAIL/WHOLESALE STORAGE/DISPLAY· EXEMPT AMOUNTS PER MIS OCCUPANCY CONTROL AREA: 900 POUNDS+ 90 GALLONS 1999 UFC SUPPLEMENT -RETAIL/WHOLE STORAGE/DISPLAY -EXEMPT AMOUNTS PER MIS OCCUPANCY CONTROL AREA: 2,300 POUNDS+ 230 GALLONS 1997 UBC TABLE 3-G/UFC TA.LBE-8003.1-B -MAXIMUM AMOllNTS PE;R BUILDING WITHOUT DETACHED STORAGE: GASES -10,000 Cl)BIC FEET SOLIDS & LIQUIDS • 25 TONS 1999 UFC SUPPLEMENT· S OCCUPANCY STORAGE WITH 8001.14 STORAGE CONDITIONS: 2,300 POUNDS+ 230 GALLONS Bulldlng·ls protected throughout by an automatic fire sprinkler system. UC I H,~1tsl I lbs · Gins Storage Amount = Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L103, Magnet Room/1.109, Mass Spectrometry Lab/L110, Robotics Lab/L101, Refrigerator/L103 New Haz Mat Locations: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrop~_orics: Storage and use-closed system conditions only. - u9 I SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 15 ·-:.~-- lunttsl Lbs Gins · .. --.. L-.,. f:.:.:111111: .... J . · 2 -~~; 1111111] ..._\ ... -(-~-:. ___ _ HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-D -UFC/CFC TABLES 7902.5-A, 7903.2-B, 8001.15-A SUMMARY -PHYSICAL HAZARD MATERIALS Isis Phannaceutlcals/lbis Laboratory-1891 Rutherford, Carlsbad CA-Control Area 2/Labs I~ater'~tja~ve~:3 · ; .-_ . .::.-·· ::::;:-,::-;;;,_: _ _.-~,::. -:., ·.-· .. ::::,~·:. I lstorage_j TOT AL Water Reacllves 3 [SOLIDS] 0.3303 . TOTAL Water Reacllves 3 [LIQUIDS) 0.7926 I units[ Lbs Gins 1997 UBC TABLE 3..0/UFC TABLE 8001.15-A EXEMPT AMOUNTS PER CONTROL AREA• H-2 .OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: 10 POUNDS+ 1 GALLON STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: 20 POUNDS+ 2 GALLONS USE CLOSED EXEMPT AMOUNT: 10 POUNDS+ 1 GALLON USE OPEN EXEM.PT AMOUNT: 2 POUNDS + 0.20 GALLON I llC ~= ~=g :~;;,tt:1~~~~~~L:!~;~:_~~1s~~~:~~~~~6~:T: 1 ~E~~':~;Ji>;i~~g6"N~~A~·~~ P~~f~~;~~o~ <:~;~~;LLONS 1997 UBC TABLE 3-G/UFC 8003,1-8-MAXIMUM AMOUNTS PER BUILDLING WITHOUT DETACHED STORAGE: GASES -2,000 CUBIC FEET . SOLIDS & LIOUiDS -1 TON 1999 UFC SUPPLEMENT -S OCCUPANCY STORAGE WITH 8001.14 STORAGE CONDITIONS: 1,100 POUNDS+ 110 GALLONS Building is protected throughout by an automatic fire sprinkler system. ·I junits.! I Lbs Gins Storage Amount= Maximum/total amount in use and storage, unless-otherwise noted. Not all materials are in use at the same time, with <10o/o In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/1.103, Magnet Room/L 109, Mass Spectrometry Lab/1.110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/1.115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts if! such a manner that concentrations and conditions create a fire or explosion potential. Pyroph~ric:5: Storage and use-closed system conditions only. uo SUMMARY-HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 16 I junitsl Lbs Gins - -.. - ,, .... =· W!:::':-Y~,5 ,.,.:,IIIIIL' "j ·-· ., ... ·, ....... , ' ; t.~ ~ .. ~ ~~ii-,r.1,a;~J _.; _ __; -~ ~ -; -;,_ ~--~:--... ,·-HAZARDOUS MATERIALS and OCCUPANCY CLASSIFiCATION ANALYSIS UBC/CBCTABLE.3~E • UFC/CFC TABLE 8001.1i;-,B SUMr.,1ARY • HEALTH HAZARD MATERIALS Isis Phannaceutlcals/lbls Laboratory -1891 Rutherford, Carlsbad CA -Control Area 2/Labs Solids Material Lbs Carcinogens 10.8475 Corros.lves 102.8441 STORAGE Liquid Gins 67.9922 115.8273 Gas Cf 10.0000 Solid Lbs USE CLOSED Liquid Gins Gas Cf Solid -Lbs USE OPEN Liquid Gins Gas Cf --------~~~·------- HlghlyToxlcs 29.8243 0.7904 5.0000 Irritants 253.1275 228.3377 5.0000 other Health Hazards 48.1540 163.5834 10.0000 Sensitizers 10.7195, 26.9472 Toxics 59.4697 56.0759 1997/1998 CODES: B/S1 OCCUPANCY CONTROL AREA CONDITIONS BASED ON THE USE and STORAGE OF HEALTH HAZARD MATERIALS. Storage Amount = Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <1 Oo/e In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 · Combustlb,le Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. SUMMARY· HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 • PAGE 17 - -'.--, ... v~·-· f1'"·-W~-··,,.,,.,_,,_. __ ·--·· __ ,, l' ~ iit... ~l ~;~~..-.:!.,, ---~;---~, ,~.~ ~ -!---HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-E • UFC/CFC TABLE 8001.15-8 SUMMARY, HEALTH HAZARD MATERIALS Isis Pharmaceutlcalsllbis Laboratory· 1891 Rutherford, Carlsbad CA • Control Area 2/Labs !Gar9'nog~ns: .. ,s:.::::;,::, -~Z=<:.:.:.:_;.~ .... ;.·:_;.--:· ·: ··.·j .· .... !· I Storage I T9T AL Carcinogens (SOLIDS] 10.8475 TOT AL Carcinogens [LIQUIDS) 67.9922 UNLIMITED CONSUMER PRODUCTS• 1997 UBC TABLE 3-E/UFC TABLE 8001.15-B: 1997 UBC TABLE 3-E/UFC TABLE 8001.1~ EXEMPT AMOUNTS: UNLIMITED • WITH SPECIAL C0NTROLS ICorrt?!!IY~·;,, ,:_,:·:.::.,.: ·.,._.·;'_./;_.,.':· :-.... : ...... . , ·. :~ .. ,_, .. ·.: : I I Storq, I TO"fAt Corrosives [UQUEFIED GASES) 10.0060 TOTAL Corrosives (SOLIDS) 102.8441 TQTAL Corrosives [LIQUIDS] 115.8273 !Units! Lps Gins rnnJts! Cf Lbs Gins 1997 UBC TABLE 3-E/UFC TABLE 8001.15-B EXEMPT AMOUNTS PER CONTROL AREA• H-7 OCCUPANCY REQURIED ONLY FOR >EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT-NO CABINETS: . 10,000 POUNDS+ 1,000 GALLONS & 1,620 CUBIC FEET STORAGE/AGGRE;GATE.EXEMPT AMOUNT -WITH CABINETS: 20,000 POU_NDS + 2,000 GALLONS & 3;240 CUBIC FEET USE CLOSED EXEMPT AMOUNT: 10,000 POUNDS+ 1,000 GALLONS & 1,620 CUBIC FEET I UC I.·. uc· USE OPEN EXEMPT AMOUNT: 2,000 POUNDS + 200 GALLONS 1997 UFC 8001.14 RETAIL/WHOLESALE STORAGE/DISPLAY •EXEMPT AMOUNTS PER MIS OCCUPANCY CONTROL AREA: 19,500 POUNDS + 1,950 GALLONS 1999 UFC SUPPLEMENT -RETAIL/WHOLESALE STORAGE/DISPLAY -EXEMPT AMOUNTS PER MIS OCCUPANCY CONTROL AREA: 20,000 POUNDS+ 2,000 GALLONS 1999 UFC CUPPLEMENT -S OCCUPANCY STORAGE WITH 8001.14 STORAGE·CONDITIONS: 20:000 POUNDS+ 2,000 GALLONS Building Is protected throughout by an automatic fire sprinkler system. I !~nits! I Lbs Gins I junttsl I Cf Lbs Gins Storage Amount = Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chem I cal Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz M,at Locations: BSL-2 Labs/L115and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. -- uo 1· uo I SUMMARY· HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS· ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 18 , ______ _ - l·unttsl Lbs Gins 1 l!nttsl C::f Lbs Gins --.. t~ '.clJilllllt.~:;~ :· -~ ... ;_,J lllllj .. -·.- HAZARDOU~ MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-E • UFC/CFC TABLE 8001.15-B SUMMARY• HEALTH HAZARD MATERIALS Isis Phannaceuticals/lbls Laboratory-1891 Rutherford, Carlsbad CA-Control.Area 2/Labs IHighly"'Toxtcs · · · · ·· · ... ., .. , ... ,,," ·· ; · · · · I , :.~-r .·~.··r\•·:~.:::.,·:.·~;r·,.,.·f:-: ::;: ·.,,. ,.~.-.:·. I Sto!'Clge I !Units! I· UC I !Units I TOTAL Highly Toxics [COMPRESSED GASES] 5.0000 Cf Cf TQTAL Highly Toxics [SOLiDS) 29.8243 Lbs Lbs JOTAL HighlvToxics [LIQUIDS) 0.7904 Gins Gins 1997 UBC TABLE 3-E/IJFC TABLE 1001,15-8 EXEMPT AMOUNTS-PER CONTROL AREA• H-7 OCCUPANCY REQUIRED ONLY FOR·>EXEMPT AMOUNTS. STORAGE/AGGREGATE EXEMPT AMOUNT -NO CABINETS: 20 POUNDS+ 2 GALLONS & 0 CUBIC FEET STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: 40 POUNDS+ 4 GALLONS & 40 CUBIC FEET USE CLOSEP EXEMPT AMOUNT: 20 POUNDS + 2 GALLONS & 40 CUBIC FEET [CAB/EXHAUSTED ENCL REQD] USE OPEN EXEMPT AMOUNT: 6 POUNDS + 0.6 GALLON 1997 UFe 8001.14 RETAIUWHOLESALE STORAGE/DISPLAY· EXEMPT AMOUNTS PER MIS OCCUPANCY CONTROL AREA: 39 POUNDS+ 3.9 GALLONS 1999 UFC SlJPPLEMENT -RETAIL/WHOLESALE.STORAGE/DISPLAY -EXEMPT AMUNTS.PER M/S·OCCUPANCY CONTROL AREA: 40 POUNDS+ 4 GALLONS 1999 UFC SUPPLEMENT -S OCCUPANCY STORAGE WITH 8001.14 STORAGE CONDITIONS: 40 POUNDS + 4 GALLONS 11rr1tants~ ... ~;.i::_.-'\ ?.~ .d·~·_.1: •. t;,\f .:~~i;::~t"J~ .... --~ .. ·.;,·:~::.. . i: -_,. -:.?"~ x :-I l·,s,or,age,_! IU..~tt.1 . I u~ .. -.! 1~n1tsj TOTA_L Irritants !COMPRESSED GASES] .. TOTAL Irritants [SOLIDS) TOTAL Irritants (LIQUIDS) CONSUMER PRODUCTS-1997 UBC TABLE 3-E/UFC TABLE 8001.15-B: 1997 UBC TABLE 3-E/UFC TABLE 8001.15.-B EXEMPT AMOUNTS: STORAGE/AGGREGATE EXEMPT AMOUNT: USE CLOSED EXEMPT AMOUNT: USE OPEN EXEMPT AMOUNT: Building Is protected throughout by an automatic fire sprinkler system. UNLIMITED UNLIMITED UNLIMITED 5.0000 253.1275 228.3377 UNLIMITED -WITH SPECIAL CONTROLS Cf Lbs Gins Cf Lbs Gihs I Storage Amount = Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat locations: Cold Room/L103, Magnet Room/l109, Ma~s Spectrometry Lab/L110, Robotics Lab/l101, Refrigerator/L103 New Haz M;.1t Locations: BSL-2 Labs/l 115 and l 116, Equip Labs/l 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. ~-···-~--- uo " ,uo. !Un!tsl Cf l,.bs Gins !Units! Cf Lbs Gins . SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RA TT AN ASSOCIATES INC. -11/13/2001 -PAGE 19 - •;,• -! -- ,-· ..,,.,..--.. !j"·---' C ~ ~ ~-irEi: "~;~--~,_~W-:-J -,,J --:,~ .. ; -: -~----""'- HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3•E • Ul;C/CFC TABLE 8001.15-B SUMMARY-HEALTH'HAZARDMATERIALS Isis Phannaceutlcals/lbis Laboratory-1891 Rutherford, Carlsbad CA -Control Area 2/labs !O~rt-jeallh '1~~~~(;/_:-,,;.:-: :'~·;.-,: ·, ·.J: :~~ ,--t-;.: ·:·._.,, TOTAL Other Health Hazards [LIQUEFIED GASES) TOT AL Other Health Hazards [SOLIDS) TOTAL Other Health Hazards [LIQUIDS). CONSUMER PRODUCTS• 1997 UBC TABLE 3-E/UFC TABLE 8001.15-B: 1997 UBC TABLE 3-E/UFC TABLE 8001.15-8 EXEMPT AMOUNTS: STORAGE/AGGREGATE EXEMPT AMOUNT: USE CLOSED EXEMPT AMOUNT: UNLIMITED UNLIMITED UNLIMITED ! ·storage_ ·I 1·un1~ I 10.0000 48 .. 1540 163.5834 Cf Lbs Gins USE 0PEN EXEMPT AMOUNT: UNLIMITED -WITH SPECIAL CONTROLS !Sen_s,uz~i:s '·.::C:-\~t;":;.,:1q_;t-:·:''.-,,;:_;,;"> ;:W~1~ :·:L:-\',;'i_::" ·: .. ~~:---:-..... -I TOTAL Sensitizers [SOLIDS} TOTAL Sensitizers !LIQUIDS) CONSUMER-PRODUCTS -1997 uec·TABLE 3-E/UFC TABLE 8001.15-B: 1997 UBC TABLE 3-E/UFC TABLE 8001.15-13 EXEMPT AMOUNTS: STORAGE/AGGREGATE EXEMPT AMOUNT: USE CLOSED EXEMPT AMOUNT: USE.OPEN EXEMPT AMOUNT: Building is protected throughout by an autoinatlc fire sprinkler system. 1-~~oi:au•.;I I 1,1~~ I UNLIMITED· UNLIMITED UNLIMITED 10.7195 26.9472 UNLIMITED -WITH'SPECIAL CONTROLS Lbs Gins UC ~ !Units! Cf Lbs Gins !Urilts! Lbs Gins Storage Amount = Maximum/total amount In use and storage, ·unless gtherwlse noted. Not all materials are in use at the same time, with <10% in use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz r.,at Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. · ~ !Units! uo Cf Lbs Gins junttsl Lbs Gins SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 20 - ----[-,,_,,.,:.,_. -. ---· '. -· ·' ----~ Fr:5f' .-.:.:..:a••• :~---J~ ... -p ...a:-..,, ~:..J ~ -; -;1111111 HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS UBC/CBC TABLE 3-E-UFC/CFC TABtE 80(!1.15-B SUMMARY-HEALTH HAZARD MATERIALS Isis Phannaceutfoals/lbis Laboratory-1891 Rutherford, Carlsbad·CA -Control Area 2/Lab~ lt.9~cs1·:.,;·_t·-":-:"s:;plt·.:":>:,,:~ IT,::·;···,{.-·,°'t:·.f,=.··· · >.:.::r-r-.: "'· ·I I .storage I lt.!nttsl 1. UC I !Units! TOTAL Toxics (SOLIDS) 59.4697 Lbs TOTAL Toxics (LIQUIDS) 56.0759 Gins 1997 UBC TABLE 3-E/UFC TABLE.8001.15-B EXEMPT AM.OUNTS PER (:ONTROL AREA• H-7 OCCUPANCY REQUIRED ONLY FOR >EXEMPT AMOUNTS STORAGE/AGGREGATE.EXEMPT AMOUNT -NO CABINETS: •· 1,000 POUNDS+ 100 GALl:.ONS.& 1,620 CUBIC FEET STORAGE/AGGREGATE EXEMPT AMOUNT -WITH CABINETS: 2,000 POUNDS+ 200 GALLONS & 3,240 CUBIC FEET USE CLOSED EXEMPT AMOUNT: 1,000 POUNDS+ 100 GALLONS & 1,620 CUBIC FEET USE OPEN EXEMPT AMOUNT: 250 POUNDS + 25 GALLONS 11197 UFC 8001.14 RETAIUWHOLESALE STORAGE/DISPLAY• EXEMPT AMOUNTS PER MIS OCCUPANCY CONTROL AREA: 1,950 POUNDS+ 195 GALLONS+ 3,160 CF 1999 UFC SUPPLEMENT.-RETAILIWHoi.ESALE.STORAGE/DISPLAY • EXEMPT AMOUNTS PER MIS OCCUPANCY CONTROL AREA: 2,000 POUNDS+ 200 GALLONS 1999 UFC SUPPLEMENT -S OCCUPANCY STORAGE WITH UFC 8001.14 STORGE CONDITIONS: 2,000 POUNDS+ 200 GALLONS. Building is protected throughout by an automatic fire sprinkler system. Lbs Gins I Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. ~ ··-:. __ _ lJO I I Units I· Lbs Gins SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS· ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 21 - I I I I I I I I I I I I I I I I I I I 1515 PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT ATTACHMENT 1-B2 -CONTROL AREA 2 HAZARDOUS MATERIALS INVENTORY ANALYSIS INVENTORY ITEMIZATION -ALPHABETICAL BY MATERIAL NAME 13 November 2001 [Rev. 1] Prepared by T Eriksen-Rattan Associates Inc. 4719 Palm Avenue La Mesa, California Telephone 619.466.6285 FAX 619.466.6233 EMAIL MaryRattan@thecoderesource.com or MaryRattan@covad.net Unless otherwise indicated, the storage amounts the maximum amounts in use and storage at any time, with use amounts <10% of the amounts indicated for storage. · Not all inventory items listed will be in use at th.e same time. ----·-· "'~ ,,.~:,-· .,,.,,.,, z-L ~J--~ ~ .. ,,.,?'_ .. , __ ,_. ·-· ... -. -1/ •:;.{~~---..C::•U> ~-~-; ••--~ ...,,<,U I ~ -: -.. ~-·-------.· -Isis Phar~~c~utical_s/lbis Laborat?ry-1(191 Rutherford, Carlsb_.d CA-Control Area 2/Labs:. liazardous Materials Inventory Item "CAS# · . .-.. :-1:' · Shtt~·-;:conc~· ·.;11ifater1a1 ·.:.:_ .. ' ;._.. ·. · ;· ,,• . . " . : .· . · .. · .:tiazafci'~,~-s.:··· : Storage.'unJts. qat,~ LEV Location . • •. . . . . ,. • . . .·.,,. ,• •t,· -• --.. 1 614-80-2 s 100 Acetamidophenol (2-) [2'-hydroxyacetanlllde] [MP 207oC] (Aldrich A7000].IHR: H2]. IR 0.0550 Lbs Control Area 2 -New Haz Mat Locatrons· ---------··---·-----2 64-19-7 L >80 Acetic Acid (Glacial) [BP 118.1QC; FP 104-109oF] [LEL: 5.4%; UEL: 15%] [pH: 2.4] CL2,CR 30.2029 Gins CLV Control Area 2 -ijew Haz Mat Locations [LD50-0ral: 3,310 mg/kg; LD50-Skin: 1,060 mg/kg] [RTECS# AF1225000] [HR: H3 F2COR] ---···------ 3 108-24-7 L 100 Acetic Anhydride [Acetic Oxide] [Acetyl Oxide] [MP-73oC; BP 138oC; FP 130oF] C~,CR,WR1 2.3776 Gins CLV Control Area 2 -New Haz Mat Locations [LEL 2.9; UEL 10.3] [LD50-0 1780 mg/kg] [RTECS# AK1925000] [HR: H3 F2 R1 COR], -------·- 4 67-64-1 L 100 Acetone [2-Propanone] [Autoignition: 869oF; FP 1oF; BP 133oF] [LEL: 2:6%; UEL: FL1B, IR 32. 7177 Gins y FLY Control Area 2 -New Haz Mat Locations 12.8%] [VD: 2.01; SG 0.786; VP: 120.7) [FV per Gin: 2020 cf) [RTECS# AL3150000) [HR: H2F3] 5 75-05-8 L >/=50 Acetonitrile [Amldite Diluent) [FP 42oF; BP 81oC) [LEL: 3; UEL: 16) (SG 0.786; VD FL1B,IR,OHH 12.3296 Gins y FLY Control Area 2 -New Haz Mat Locations 1.41) [LD50-0 2730 mg/kg; LC50 21,354 ppm) [RTECS# AL7700000] [HR: H2 F3] 6 62-44-2 s 100 Acetophenetidlde (P·).[Florinal] [Phenacetin] [4'-Ethoxyacetanilidej [MP 134oCJ [Aldrich 235830] [HR: H2J CA,OHH,P6~ 0.0110 Lbs Control Area 2 -New Haz Mat Locations ·---·------·----7 ~424-85-7 s. 100 Acid Blue 40 [Cl 62125] [Aldrich 2105441 [HR: H 1] IR 0.1101 Lbs Control Area 2 -New Haz Mat Locations 8 79-06-1* t >/=20 Acrylamide [Bls-Acrylamidej [Pro\ogelj [RTECS#AS3325000] [LD50-0: 124-625 CA, IR, OHH, TX, 0.2642 Gins Control Area 2 -New Haz Mat Locations mg/kg; LD50-S: 400-2,000 mg/kg] [RTECS# AS3325000] [HR: H3] P65,RMP-T3 9 79-10-7 L 100 Acrylic Acid [2-Propenolc Acid) [Propene Acid] (Elhyle~ril9xyllc Acid) [Acroleic CL2,CR,HT, 0.0220 Gins y CLV Control Area 2 -New Haz Mat Locations .Acid) [VlnylfOlllllcAcidj [FP 130oF; BP 141oF] [LD50-0ral: 33.5 mg/kg; tD50-Skin: OHH, UR2 280 mg/kg; LC50-lnhalation: 8,000 ppm] [FP 130oF; BP 141oF] [HR: H4 F2 R2 CORI 10 18422-05-4 s 100 Adenosine 5'-MonophosphoricAcld (Adenoslne 5'-Monophosphate MonohydrateJ IR 0.0220 Lbs Control Area 2 -New Haz Mat Locations [AMP Monohydrate] [AP5AJ [A-5'-PJ [AP5J [MP 200odec] [RT~CS# AU7480500] [HR: H1J 11 5\)-65-5 s 100 Adenosine-5'-Triphosphate (ATP) (MP 1760 dee] [Aldrich A26209 et al] [HR: H1] IR 0.0220 Lbs Control Area 2 -New Haz Mat Locations 12 9012-36-6 s 100 Agarose [Sepharose 6B] [Sepharose 4B] [Sepharose.2B] [MP 260oC] [Aldrich NH 1.1564 Lbs Control Area 2-New Haz Mat Locations 191159, 137049, 194158] [HR: OJ 13 107-95-9 s 100 Alanine (B-) [MP 205oC] [Aldrich 239720 et aij [HR: H1] IR 0.1101 Lbs Control Area 2 -New Haz Mat Locations 14 302-72-7 s 100 Alanine (DL-) [RTECS# AY29BOOOOJ [HR: OJ NH 0.2202 Lbs Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilatlon required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount = Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% in use at any time. Control Area 2: Entire bulldlrig, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115and L116, Equip Labs/L120, Glasswash Lab/.l113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Bulldlng Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC.· 11/13/2001 • PAGE 1 ·:~( ... ·.· ... --·-L-W£-~~4Z -·-· ····-. :-~-,.,.,_. __ .. ·1-· .. _ _.. -· -• -,•';'-I •r:-~.....,lllmlllt:~R-·---,,,,cJ· ~ ~ " . .. :·-----, __ _ Isis l>harmaceuticals/lbis Laboratory -1~91 Rutherford, Carlsbad CA -Cont_rol Area 2/Labs: Hazardous Materials Inventory • .:,'. ..,•w ''• ,. '1, •• •,.•' ~---~·-::-~,.-I~..:~------;----, ... :·,;. .-. ltem-·cAS#· --·.,;·--state-r-·conc%·-·Materlal .·.,_.,,..·,·, .... · · ,_;, · .-.. . . . .. .... : , . . . . . ... : •.· ..... •.J.·: ~-' . .'___i:_ •• : ••• -----'- ._:·._. ·."iHazard Ciass"·. · St~ge. U,-ilts Cabs LEV ... '• . . - 15 14316-06-4 S 100 Alanine Methyl Ester Hydrochloride (D-) [MP 108oC) [HR: H1J IR 16 9048-46~ s 17 107-18-6 L 18 106-95-6 L 19 1344-28-1 s 20 · 23109-05-9 s 21 9002-29-3 s 22 39831-55-5 s 23 584-13-4 ·s 24 616-30~ L 25 50541s93.Q I:. 26 4048-33-3 s 100 Albumin [FITCJ [Protein Assay Reagent] [Protein Standard] [Cohn Blood Fractions] NH [Bovine Serum Albumin) [BSA] [HR: OJ 100 Ally! Aloohol [2-Propenolj [Viny! Carblnolj [2.Propen-1-01] FP 72oF; BP 96oF) [LEL: CR, FL 18, HT, . 2.5%; UEL: 18%ISG 0.854; VQ 2.01] LD50-S: 45 mg/kg; LC50: 330 pp] [HR: H3 F3 OHH, UR1, RMP- R1 COR] T1, RMP-T3 100, Ally! Bromide [3-Bromoprop[ene)[2-Propenyt Bromide] [MP -1190; BP 70oC; FP 2BoF) [LEL 4:4; UEL 7.3] [SG 1.43; VD 4.2] [LD50-0 100 rngA(gj [RTECS# UC7090000] (HR: H3 F3) 100 Aluminum Oxide [Alumina] [Chromatrographlc Sorbent] [BoileezersJ [Catalyst] [RTECS# 8D1200000) [HR: OJ 100 Amanitine (a-) [Aldrich A,2263 -Listed as Toxic no LC/l.D50 data availableD [RTECS# BD61950QOJ [HR: H2J 100 Amberlite IRC-50.lon Exhange Resin [HR: H2] 100 Amikacln Sulfate [Antioblotic BB-KB Sulfate] [Amikln] [MP 220oCJ [Sigma A 1774] [LD50-0 >4 gmikg] [RTECS# WK1961200J (HR: H2] 100 A!lllno-1,2,4-Triazole (4-) [MP 84oCJ [Aldrich A81803J [HR: H2] 100 Amino-1,2-Propanedlol (3°) [1:Amlnoglyceroq [B: 264ol739mm; FP >230oF] [RTECS# TY2~00000) [HR: H2 F1 CORJ FL 1 B, IR, OHH, TX NH IR,OHH,TX IR OHH,P65 IR Cl:.38,CR 100 Amino-1-Benzylplperidine (4-) [FP >230oF; $G 0.933] [Aldrich 195812] [HR: H2 F1] CL3B, IR 100 Amino-1-Hexanol (6-) [MP 56oC] [Aldrich A56353] [HR: H2) IR 0.0550 Lbs 0.0055 Lbs 0.0264 Gins Y FLV 0.0220 Gins Y FLV 2.2100 Lbs 0.0002 Lbs 1.1013 Lbs 0.0022 lbs 0.0220 Lbs 0.0220 Gins 0.0110 Gins 0.2202 Lbs LociatlQn Cqntrot Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations ----------·-·- Control Area 2 -New Haz Mat Locations -Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control·.Area 2 -New H11z Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2.-New Haz Mat Locations 27 156-87-6 L 100 Amino-1-Propanol (2-) (3-PropanolamlneJ [BP 1887oC; FP 175oFJ {RTCS# UA~6000000J [HR: H3 F2 CORJ CL3A,CR 0.1101 Gins CLV Control Area 2 -New Haz Mat Locations 28 62069~7-8 s 29 115-69-5 s 100 Atnino-2-Buteliethioamlde. (3-) [MP 135oCJ [Aldrich 294608] (HR: H2J 100 Amlno-2-Methyl-1,3-Propanediol (2-) [Melhylaminopropanedlol] [MP 108oC) [RTECS# TY2975000] [HR: H3 CORI IR CR 0.0550 Lbs 0.1101 ~bs Conlrol'Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maxlmumftotal amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% in use at any time. Control Area 2: Entire building, excluding Chemical Waste StoragefRooms L 114 & L 117. Existing Haz Mat Locations:. Cold Roomfl 103, Magnet RoomfL 109, Mass Spectrometry LabfL 110, Robotics LabfL 101, Refrlgeratorfl 103 New Haz Mat Locations: BSL-2 LabsfL115 and L116, Equip Labs/L120, Glasswash LabfL113, Open Lab/L107 Combustible Dusts: No use, manufacture, or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. . HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 2 - ... ,,~ -ti,;-.e· -f.~'r'.;' !;~og::; l.J?-' .. }/:ft; .. ·'"'!-·· . -·· .. -·: -· --. --; -·--~ ~ ~ I...J ... --Q.,,,."f" ~. ·"-~' ... ~ -.-"'=-,,.r,,,/f ,.._,_ -.--.:Ar • ... • ~, •.. :... \~-~·- Isis Pharm~ceuticals/lbis L~boratory -1891 Rutherfqrd, Carlsbad CA -Co11trol Area 2/Labs: H;tzardous Materials Inventory Item CAS# . ' : . State_ ... Con.co/a., ":'~~erlak·> .'· . '.Hazard·~IIISS Storag, · Units Cabs LEV location 30 124-68-5 L 31 1779-81-3 s 32 3182-95-4 s 33 56-05-3 s, 34 82039-90-5 s 35 41680-34-6 s 36 5326-47-6 s 100 Amino-2-Melhyl-1-Propanol (2-) [lsobutanol-2-Amine) [AMP Buffer] [MP ?4oC; BP CL3A, IR 165oF; FP 153oF] [LD,50-0 2,900 mg/kg] [RTECS# UA5950000) [HR: H2 F2] 100 Amino-2-Jhlazoline.(2-) [RTECS# X.16540000] [HR: O] 100 Amino-3-Phenyl-1-Propanol [(S)-(-)-2-l[L-Phenylalanlnol] [MP 920] [RTECS# UA6900000) [HR: H2] 100 Amino-4,6-Dichloropyrimidine (2,) [MP 219oC) [Aldrich A48601] [HR: H1] 100 Amlno-4-Nitrolmldazole (5-) [MP 283oC] [HR: H1) 100 Amino-4-Pyrazolecarboxylic Ackl (3-) [MP 135oCJ [Aldrich A77407][HR: H2] NH IR IR IR IR 100 Amlno-5-lodobenzoic Acid (2-) [5-lodoanlhranlllc Acid] [MP 219oCJ [Aldrich A59603) IR [HR: H2] . 0.2642 Gins CLV Control Area 2 -NewHaz Mat Locations 0.0550 Lbs Control Area 2 -New Haz Mat Locations 0.0220 Lbs Control Area 2 -New Haz Mat Locations 0.0220 Lbs Controt·Area 2 -New Haz Mat Locations 0.0220 Lbs Control Area 2 -New Haz Mat Locations 0.0550 Lbs Control Area 2 -New Haz Mat Locations 0.0550 Lbs Control Area 2 -New Haz Mat Locations Control Area 2 -New 1-Jaz Mat Locations 3_7 6285-57-0 S 100 Amlno-6-Nltrobenzolhiazole (2-) [MP 2470] [RTECS# DL0865000] [HR: H1] IR 0.1101 .Lbs -'----'-----------------------------------------------""7""------------- 38 35975-00-9 S 100 Amino-6-Nltroquinoline (5-) [MP 272oC) [Aldrich 1450?5] [HR: H1] IR 0.0330 Lbs Control Area 2 -New Haz Mat Locations. 39 22483-09-6 L 100 Amlnoacetaldehyde Dimelhylacetal [2,2-Dimelhoxyethylamine] [BP 135oC/95mm; Ct2, IR FP 128oF] [HR: H2 F2] 0.0005 Gins CL V Control Area 2 -New Haz Mat Locations 40 2635-68-9 ·S 41 150-13-0 s 42 56-12-2 s 43 15846-25-0 s 44 21568-87-6 s 45 35303-76-5 s 46 111-41-1 L 100 Aminobenzamlde (4-) [Benzamldine Agarose] [MP 181oC] [Aldrich 284572] [HR: H2] IR 100 Aminobenzoic At;ld (4-) [p-Amlnobenzolc Acid] [Paraaminobenzoic Acid] [PABA) IR [MP 1876) [RTECS# DG14QOOO(lj [HR: H1j 100 Amlnobutyric Acid (4-) [GABA] [Gamma-Amino-n-Butyric Acid) [GABA) [MP 195oC] IR [RTECS# ES6300000] [HR: H1] 100 Aminocrotonamide (3-) [HR: H2] IR 100 Amino-e-Caprolactam (L-a-) [(S)-{-)-3-Aininohexahydro-2-Azepinone] [MP 57oC) IR [HR: H2) ' 100 Amlnoethyl Benzenesulfonamide (4-2-) [4'(2-Amlnoethyl)Benzene Sulfonamide) MP IR. 150oC] [Aldrich 275247] [HR: H1) 100 Amlnoethylaminoethanol (2-2-) [BP 140oC; FP >290oF] [LD50-0 3 gm/kg; LD50-S CL3B, CR, SN 2250 mg/kg] [RTECS# KJ6300000] [HR: H3 F1 COR] . 0.0550 Lbs Control Area 2 -New Haz Mat locations . 0.0440 Lbs Control Area .2 -New. Haz Mat Locations 0.0550 Lbs Control Area 2 -New Haz Mat Locations 0.0550 Lbs Control Area 2 -New Haz Mat Locations 0.0220 Lbs Control Area 2 -New Haz Mat Locations 0.0550 Lbs ControfArea 2 -New Haz Mat Locations 0.5283 Gins Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable.Liquid Vapor. Storage Amount= Maximum/total amount.In use and storage, unle~s otherwise noted. Not all materials are in use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustlbl,e Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophori~: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 3 ·- ,.: . .-... __ w_·r:-f,M• ~-~4,ir I.'.:~~:-·:,-": __ ::_:i -"~ . ._-s --'. __ : ______ , ______ _ Isis Pharmaceuticals/Ibis Laboratory-1891 Rutherford, Carlst,ad CA-Control Area 2/Labs: Hazardous Materials Inventory .. -----.-,-.. '' ·1te~·,:·~AS~?.: · /,;. ~tate:\§.~~~f~--:~ateria1 •: · :'.·<,-::· , .. · '·. .. ' · .. • .. • ··: .J .... Hazar'd·Class. · Storage. Units . Cabs LEV . L~tlon ... 47 62-57-7 s 100 Aminolsobutyric Acid (2~) [2-Melhylalanlne] [P 300?C) [Aldrich 850993) (HR: H1) IR 0.0771 Lbs Control Area 2-New·Haz Mat Locations ----·--·-- 48. 1750-42-1 L 100 Aminolsoxazole (3-) [BP 75oC; FP >230oFJ [Aldrich 424218) [HR: H1 F1) Ct3B, IR 0.0053 Gins Control Area 2 -New Haz Mat Locations 49 3731-51-9 L 100 Aminomelhylpyridine (2-) (2-Picolylamine) [BP 83oC; FP 194oF) [RTECS# CL3A,CR 0.0550 Gins CLV Control Area 2 -New Haz Mal Locations US1840000) [HR: H3 F2 COR] -··----________ ,._ 50 4319-49-7 L 100 Aminomorpholine (4-) [BP 168oC; FP 137oF] [RTECS# QD7300000) [HR: H2 F2) CL2,IR 0.0220 Gins CLV Control Area 2" New Haz Mat Locations 51 551-16-6 s 100 Aminopenlcillanlc Acid (6-) [2-(2'-Carboxyphenol)Benzoyl-6'Aminopenicillanic Acid) IR,SN il.!)022 Lbs Control Area 2 -New Haz Matlocations [6-APA) [MP 198oC] [Aldrich A70909) [HR: li2) 52 95-55-6 s 100 Amlnophenol (2-)[MP 174oC) [Aldrich A71301) .[HR: H2] IR 0.2202 · Lbs Control Area 2 -New Haz Mat Locations --- 53 123-30-8 s 100 Amlnophenol (4-).[LD.50-0.375 ~g) [MP 189oC) [RTECS# SJ5075000) [HR: H2] IR,OHH,TX 0.2202 Lbs <;:ontrol Area 2 -New Haz Mat Locations 54 30418-59-8 s 100 Amlnophenylboronic Acid Monohydrate (3-) {3-Aminobenzeneboronic Acid) [MP IR 0.0110 Lbs Control·Area 2 -New Haz Mat Locations 94oC) [Aldrich 287512) [HR: H2] 55 107-11-9 L 100 Aminopropene (3-) [Allylamine] [2-Propen-1-Amine] [3-Aminopropylene] [2-FL 1B, HT, IR, 0.0165 Gins y FLV Cc:mtrol Area.2 -New Haz Mat Locations· Propenamide) [MP -860; BP 53oC; FP -20oF) (L050-S: ~5 mg/kg; L05()-0: 106 OHH, PSM, RMP- mg/kg; LC50: 572ppm] [LEL 2.2; UEL 22) [SG 0.761; VD 1.976] [RTECS# T1 BA5425000] [HR: H4 F3) 56 50~9-61-6 ·s 100. Aminopyrazine [MP 119oC) [Aldrich A76958J [HR: H2] IR 0.0440 Lbs C9ntrol Area 2 -New Hilz Mat Locations 57 1820-80-0 s 100 Aminopyra;zole (2-) [MP 37oCJ [B(' 218ol122mm; FP >230oFJ [HR: H3 COR] CR 0.0220 Lbs Control Area 2 -New Haz Mat Locations 58 34781-86-7 s 100 Aminoresorcinol Hydrochloride (4-) [MP 220oC) [Aldrich 163171] [HR: H1) IR 0.0110 Lbs Control Area 2·. New Haz MafLocations 59 932-52-5 s 100 -, Aminouracil (5-) IMP >300oC] [Aldrich 855286] [HR: H1) IR 1.7841 Lbs Control Area 2 -New Haz Mat Locations 60 631-61-8* L </=90 Ammonium Aceta_te [Aqueous Solution) [Ammonia Acetate Soil Extractant IR 0.7925 Gins Control Area 2 -New l:!az Mat locations Concentrate] [pH 6-8] [HR: H1J 61 631-61-8 s 100 Ammonium Acetate [MP 110oC) [RTECS#AF3675000) [MP 110oC][HR: H1) IR 6.8428 Lbs Control Area 2 -New Haz Mat Locations 62 1066-33-7 s 100 Ammonium Bicarbonate [Ammonium Hydrogen Carbonate) [RTECS# B0860000DJ IR 1.1013 Lbs Control Arlla 2 -New Haz Mat Locations [HR:H1J ~ 63 506-87-6 s 100 Ammonium Carbonate [RTECS# BP1925000) [HR: H1] IR 2.21po Lbs Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustlble Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount in use and storage, uniess otherwise noted. Not all materials are in use at the same time, with <10% in use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L103, Magnet Room/L109, Mass Spectrometry Lab/L110, Robotics Lab/L101, Refrlgerator/L103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS· ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 • PAGE 4 - i-~-<t~I j e··---W''c' f .. --~ ~ ti:.,__ r-=::~-----~·-:\~1111;~,.-~:-, .. J -.:_:,--.; ... -----'.:; ___ -----:~- Isis Pharmaceuticals/Ibis Laboratory -1891.Rutherford, Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory ·1tem,/~~~-:i:;_(:\\$~~e:··~o~~\~aitir1~{~fi~}/'t--._·:,;-:::,:,:· -:/_, / :._, '· ,: ,·:. :"·: . :.: Hazard .Class .... :·:storage ·: Units .. : . ·.'.-_ . .__ . . , 64 12125-02-9 S 100 Ammonium Chloride [LD50-0: 1,650 mg/kg] [RTECS# BP4550000] [HR: H1] IR 6,6153 Lbs 65 540-69-2 s 66 1336-21-6 L 67 12054-85-2 s 68 7727-54-0 s 69 7722-76-1 s 70 -7783-20-2 s 71 12135-76-1 L 100 Ammonium Formate [Formic Acid Ammonium Sall] [MP 1190] [RTECS# IR BQ6650000) [HR: H1]. >50 Ammonium Hydroxide [Aqua Ammonia] [NH40H) [pH >13) [Base] ILD50.0ral: 350 CR, TX mg/kg] [HR: H3 CORI 100 Ammonium Mofybdale(VI) Telrahydrate [tD50-0: 333 mg/kg) [Aldrich 43134~) [HR: IR, OHH, TX .H3) 100 Ammonium Persulfate (Ammonium Peroxydisulfate] [APSJ (LD50-0 689 mg/kg) [pH CR, OX1, SN 1-2) (RTECS# SE0350000) [HR: H3 COR OX] · 100 Ammonium Phosphate Monobaslc [Monoammonlum Phosphate] (Bestphos 11-55-0] IR !A.mmonium Dlhyrogenphosphate) [MP 190oC] [Aldrich 204005, et aij [HR: H1] 100 Ammonium Sulfate [Viking Ship Ammonium Sulfate 21-0-0) [(NH4)2S04] (MP >2800 IR dee] (RTECS# B~500000]'[HR: H1) </=50 Ammonium Sulfide [Ammonium Bisulfide) [Diammonlum Sulfide] [Ammonium CR, FL 1C, TX Monosulf!de) [</= AqUeoJJS Solution) [BP 40oC/760mm; FP 73.6oF] [SG0.997; VD 2.358) [LD50-0rai: 168 mg/kg] (RTECS #BS4920000) [HR: H3 COR) 3.3113 lbs 1.9820 Gins 0.2202 Lbs 0.0771 L~s 4.4200 Lbs 7.7313 Lbs 0.0066 Gins 72 69-53-4 . S 100 Amplcillin [0(-)-alpha-Amlnobl!nzylpenicilllnl[MP 208oC](Aldrlch 271861][HR: H2] IR, 0HH 0.0550 Lbs Cabs LEV Y FLV Location . Con)rol Area·2. New Haz Mat LocaUons Control Area 2 -New Haz Mat Locations . Control Area 2 -New Haz Mat LocaUons Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Arel! 2 -New Haz Mat Locations Control Area 2 -New Haz Mat LocaUons Control Area 2 -New Haz Mal Locations Control Area 2 -New Haz Mat LocaUons ---------~------~---~-~-~----~-------,----~~~-~--------------- 73 75-85-4 L 100 All)yl Alcohol (t-) [tert-Pen_tyl Alcohoij [2-Melhyl•2-Butanol) [BP 70oF; BP 1020) [LEL FL 1B, IR, OHH 0.5507 Gins 1.2; UEL 9) [SG 0.805; VD 3] [LD50-S: 4490 mg/kg; LD50-0: 3030 mg/kg) (RTECS# SC0175000] [HR: H2 F3] Y Fl.:V Control Area 2 -New Haz Mal LopaUons 74 62-53-3 L 100 Aniline [Aminobenzene) [MP -Go; BP 1840; FP 158oF] [LD50-S: 1409 mg/kg; LD50-CA, CL3A, IR, 0.1101 Gins CLV Control·Area 2-New Haz Mat LocaUons 75 66687-07-8 s 76 135-02-4 L 77 100-09-4 s O: 250 mg/kg] [RTECS# BW6650000] [HR: H3 F2] OHH, TX, P65, RMP-T3 100 .Aniline Blue Diammonium Sall[Aldrich 415049] [HR: H1J 100 Anlsaldehyde (o-) [2-Methoxybenzaldehyde] (MP 34oC; BP 238oC; FP 244o~) [RTECS# BZ2610000] [HR: H2 F1] IR CL3B,IR 100 Anlsic Acid (p-) [4-t:,ielhoxybenzoic Adie] [MP 1820) [RTECS# BZ4395000) [HR: H2] IR 0.0550 Lbs Control Area 2 -New Haz Mat Locations 0.0220 Gins Control Area 2 -New Haz Mal tocaUons 0.2313 Lbs Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Clas.s I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 Ne'w Haz Mat Locations: BSL-2 LabsfL115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 5 -- ---.. c-~-tt; <il;.;...j·r-· •,·a---,-··-·-,,-·,, -·J -· ·, -'--~,;..;. ~ ,.,...,;. ,. ___ J ~ __ ;,,/ • u~ ·~ • _., .._ • ;_~-----~--Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Carlsbad CA -Control Area 2/Labs: Hazardous Materials lnvent9ry , Item __ !;~-\ ;_ .. ' "~~t~;~~~c~·~·~,a~~~i,(;_'·_; .·:'.'.:/i.,,-:_::;-. :.-., .. ·· · .. . · ... :_'_:;;-Hmi:d Cl~~s ·· ··. Storage·'-:.Unlts · Cabs LEV \. . .. -· . . . . . .. . . ' .. -Location · 78 1711-05-3 L 100 Anisoyl Chloride (m-) [3-Methoxybenzoyl chloride] [BP 123oC; FP 198oF) [Aldrich CL3A, CR, WR1 0.1101 Gins CLV Contrpl Area 2 -New Haz Mat L~tions ?30243] [HR: H3 F2 R1 CORI 79 87-72-9 s 100 Arabinose {!.(+)·} [MP 160oC) [Aldrich A91~06] [HR: H1) IR 0.2202 Lbs Control Area 2 -New Haz Mat Locations ---·-· 80 7440-37-1 CG 100 Argon [Ar] [aw: 39.94] [9.7 cfnbJ [HR: OJ NH 2910.0000 Cf Control Area 2 • New Haz Mat Locations --···----- 81 10465-81-3 s 100 Azodicarbonyldlpiperidine (1,1'-) [mP 134oCJ [Aldrich 255!_K)2 etaij [HR: H2] IR 0.0550 Lbs Control Area 2 -New Haz Mat Locations 82 10'361-37-2 s 100 Barium Chloride [MP 563o] {1.D50-0: 118 mg/kg] [RTECS# CQ8750000) [HR: H3] IR,OHH, TX 0.1321 Lbs Control Area 2 -New Haz Mat Locations --~-- 83 280-64-8 L </=25 BBN (9·) [0.5M Solution in Hexanes, Telrahydrofuran or Toluene] [9-FL1B, IR, OHH, 0.0026 Gins y FLV Control Area 2 -New Haz Mat Locations Borablcylo(3,3,2)-Nonane] [BP 68-70oC; FP-15oF to 1oF] [Aldrich 45946 etaij [HR: SN, WR2 H3F3R2] 84 618-31-5 L 100 Ben~I Bromide (a,a-Dibromotoluene] [BP 156oC/23mm; FP >230oF; SG 1.51] CL3B,CR 0,0550 Gins Control Area 2 -New Haz Mat Locatioils [Aldrich 123560] [HR: H3 F1 COR] ' . 85 71-43-2 L 100 Benzene [MP 5.5oC; BP 80oC; FP 12oF] [SG 0.874; VD 2.703] [LEL 1.4; UEL 8] CA, FL1B, IR, 1.3207 Gins y 'FLV Control Area 2 -New Haz Mat Locations [RTECS# CY1400000] [HR:·H3 F3] OHH,P65 -·--·- 86 108-45-2 s 100 Benzenediamine (1,3-) [1,3-Phflllyfenedlamine] [m-Diaminobenzene] [m-IR,SN 1.9824 Lbs Control Area 2 -New Haz Mat Locations Phenylenedlamine] [MP 64oC; BP 282oF] [LD50-0ral: 300 mg/kg; LD50-Skin: 5000 mg/kg] [HR: HJ] 87 108-90-5 L 100 Benzenethiol [Thlophenoij [BP-15o; BP 1690; FP 123oF] [LC50: 132 ppm; LD50-0; CL2, HT, OHH 0.0220 Gins · y CLV Control Area 2 -New Haz Mat Locations 46200 micrograms/kg; LD50-S: 300 mg/kg] [RTECS# DC05250000) [HR: H4 F2] 88 51-17-2 s 100 Benzimklazole [RTECS# 0D5425000] [HR: H1] IR 0.2202 lbs Control Area 2 • New Haz.Mat Locations 89 15788-16-6 s 100 Benzimidazolecarboxylic Acid (5-) [HR: H2] IR 0.011,0 Lbs Control Area 2 -New Haz Mat Locations 90 57842-27-0 s 100 Benzodlthol-2-Ylium Tetrafluoroborate (1,3-) [MP 150oC] [HR: H2] IR 0.0110 Lbs Conliol Area 2 -New Haz Mat Locations 91 98-88-4 L 100 Benz<>yl Chloride [1:Chlorobenzaldehyde] [Benzolc Acid Chloride] [MP-1oC; BP CL3A, CR, UR1, 0.2906 Gins CLV Control Area 2 -New Haz Mat Locations 198oC; FP 156oF] [RTECS# DM6600000] [HR: H3 F2 R1 COR WR] WR1 92 611-73-4 s 100 Benzoylformic Acid [phenylglyoxylic acid] [MP 65oC] [Aldrich B13055] [HR: H2] IR 0.0550 Lbs Control Area 2 -New Haz Mal Loc;ations 93 5437-45-6 L 100 Benzyl 2-Bromoacetate [BP 1660; FP >230oF] [RTECS# AF5957215] [HR: H2 F1] CL3B,IR 0.0220 Gins Control Area 2 • New·Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class 1,.11 and lll·A liquids use-open conditions. CLY-Combustible liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC.· 11/13/2001 • PAGE 6 --.. ~flal~~' .-~~~:--~_:: -...:...:r• .. :J allJ -) -;-:_ .. ,--'"=·- Isis Pharmaceuticals/Ibis Laboratory-1891 Rutherford, Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory Hem· i_C::A,$f i:. ,,. _. .. \~,.t~:>c~-~~;,'. ~.!ltt.riar. ·: :;:; ,: }t. i· ·>, _ ·: . ~-: .... .: ·_ .H~ard Cl~s :· · . Storage . Units Cabs LEV .. . . Location . ... . . . 94 100-51-6 L 100 Benzyl Alcohql [Hydroxytoluene] (Benzenemethanol] [HY 28~] [BP 20~oC/760mm; CL3B, IR, OHH 0.5283 Gins Control Area 2 -New Haz Mat Locations FP 201oF] [l:050-0: 1,230 mg/kg;.LD50-S: >2,000.mg/kgJ [RTECS# DN3150000J [Aldrich 108006) [Incompatible with Oxidizers} [HR: H2 F1J ~ 95 77987-49-6 s 100 Benzyl N-(2-Hydroxyethyl)Carbamate [MP 58oC] [HR: H1] IR 0.0550 Lbs Control Area 2 -New Haz Mat Locations 96 31166-44-6 L 100 Benzyl-1-Piperazl11ecarboxylate [BP 158oC; FP >230oFJ [Aldrich 456926) [HR: H1 CL3B,IR 0.0550 Gins Control Area 2 -!'lew Haz Mat Locations- · F1] ------ 97 2687-43-6 s 100 Benzylhydroxylamine Hydrochloride (~) [MP 238oC] [RTECS# NC3040000] [HR: H2) IR 0.2202 Lbs Control Area 2 -New Haz Mat LocatiOns - 98 3987-53-9 s 100 Benzylimlnodlacetic Acid (N-) [MP 200oC) [Aldrich B24758] [HR: H1 I IR 0.0550 Lbs Control Area 2 -New Haz Mat Locations 99 150.:25-4 s 100 Blclne [N,N-Bls(2:i-iydroxyelhyl)Glycine) [Protein Assay Kit-Bicinchonlc Acid] [MP 190oC)'[RTECS# MB9700000] [HR: H2] IR 0.2202 Lbs Control Area 2 -New Haz Mat Locations 100 58-85-5 s 100 Biotin (D-) [Vitamin HJ [(+)-BloUn) [RTECS# X.19088200] [HR: H1] OHH 0.0022 Lbs Control Area 2 • New Haz Mat Locations 101 5070-13-3 . s 100 Bis(4~Nilrophenyl)Carbonale [d~p-Nitrophenyl) Carbonate) [MP 136oC] [Aldrich IR 0.0220 Lbs Control Area 2 • New Haz Mat Locations :161691] (HR: H1] 102 7703-74-4 s 100 Bis(8romomelhyl)Pyrldine (2,6-) [MP 1520] [Aldrich 405426] [HR: H1] IR 0.0110 Lbs Control Area 2 -New Haz Mat locations 103 56183-63-2 s 100 Bis(Dilsopropylamino)Chlorophosphine [MP 100oC] [Aldrich 341347] [HR: H3.R2 CR,WR2 0.2202 Lbs y Control Area 2 -New Haz Mat Locations CORWR] 104 10416-59-8 L 100 Bis(trimethylsily)acetamlde [BSA] [BP >100oF; FP 53oF {SG 0.832] [RTECS# FL1B,IR,WR1 0.0264 Gins y FLV Control·Area 2 -New Haz Mat Locations AK3000000J [HR: H2 F3 R1 WR1] 105 4530-20-5 s 100 Boe-Glycine (N-t-) [N-(lert-Bufoxycarbonyl)GlycfneXN'.t-)J [HR: H1] IR 0.0220 Lbs Control Area 2 • New Haz Mat Locations 106 13292-1!7-0 L 100 Borane Meqiyt SuHide Complex [FP 656F;·BP >100oF] [SG 0.801] [RTECS# FL 1B, IR, UR2, 0.0528 Gins y FLV Control Area 2 ° New Haz Mat locations PV5080000J [HR: F3 H2 R2] WR2 107 110-51-0 L 100 Borane-Pyrld\ne Complex [MP 10oC; FP 164oF; SG: 0.929! [LD50-0: 945 mg/kg; CL3A, IR, OHH, 0.0550 Gins CLV Control Area 2 -New Haz MatLocations LD50-S: ioo mg/kg] [RT[:CS# US3675000] [HR: H2 F2 R1] TX,UR1 108 10043-35-3 s 100 Boric Acid [RTECS# ED4550000] [HR: H1] IR 0.2202 Lbs Control Area 2 -New Haz Mat Locations 109 5979-11-3 s 100 Bradykinin Acetate Salt [Arg-Pro.Pro-Gly-Phe-Ser-Pro.Phe-Arg] [Sigma B3259) [HR: IR 0.1000 Lbs Control Area 2 -New Haz Mat Locations H1] ---~---·---·· LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustlble Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% in use at any time. Control Are!l 2: Entlre·building, excluding Chemical Waste Storage/Rooms L 114 ·& L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spect~ometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz-Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open.Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 7 - ··· .. :.,, --.. •··-.r,;,.: L e,:. < T ·;,:::w_,:,:.~-:,:.,>..__J .._; ___ : --·-, __ : ........ -··-· Isis Pharmaceuticals/Ibis Laboratory-1891 Rutherford, Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory Item :-p~~{'.::·:'. ;'.: ·:~tate-.,:~o~~)~1~l~~~I '.N/:' : '; .:>·.:\>:· ·· · '::\ . .. .. . ' .:·'. -".',·. :. Hazard Class · . s•orage · Units . Cabs LEV Location 110 128-08-5 s 100 Bromo-2,5-Pyrolldlnedlone (1-) [N-Bromosucclnlmlde] [NBS) [SuccinibromimldeJ [HR: CR 0.3304 Lbs Control Area 2 -New Haz Mat Locations H3COR] 111 870-63-3 L 100 Bromo-2-Methyj-2-Butene (4-) [3,3-Dimethylallylbromkle) [BP 59oC; FP 91oF; SG CR,FL1C 0.0220 Gins y FLV Control Area 2 -New Haz Mat Locations 1.293] [HR: H3 F3 COR) 112 2227-64-7 s 100 Bromo-3'-Nitroacetopherione (2-) [3'~Nitrophenacyl Bromide] [HR: H3 COR) CR,OHH 0.0771 tbs Control Area 2 -New Haz Mat Locations 113 683-57-8 s 100 Bromoacetamide (2-) [MP 8BoCJ [RTECS# AB4587000) [HR: H3 COR] CR 0.0220 Lbs Control Area 2 -New Haz Mat Locations ·-- 114 79-08-3 s 100 B~cetlc Acid [MP 49oC; BP 208oC; FP >230oF] [LD50-O: 50 mg/kg; LD50-S: CR,HT,OHH 0.2202 Lbs y Control Area 2 -New Haz Mat Locations 100 mg/kg] [RTECS#AF5950000] [HR: H4 COR] 115 598-21-0 L 100 Bromoacetyl Bromide [BP 147oCll60mm; FP None; SG 2.317) [AkJrich.B56412] CR,WR2 0.1101 Gins y Control Area 2·-New Haz Mat Locations [HR: H3 R2 COR WR) 116 1122-91-4 ,. s 100 BromobenzakJehyde (4-) [MP 44oC;·FP 22BoF] [RTECS# CU48100000) [HR: H2) IR 0.0550 Lbs Control Area 2 -New Haz Mat Locations 117 586-76-5 s 100 Brornobenzoic Acid (p-) [MP 252oC] [Aldrich 108510) [HR: H2] IR 0.2753 Lbs Control Area 2 -New Haz Mat Locations 118 623-00-7 s 100 Bromobenzonltrile (4-) [MP 112oC) [LD50-O: 237 mg/kg] [RTECS# D124600000] IR,TX 0.1101 Lbs Control Area 2 -New Haz Mat Locations [HR: H2] -·------- 119 80-58-0 'L 100 Bromobutyric Acid (2-) [MP -4oC; FP 99oC/10mm; · FP >230oF] [No LC/LD 50 data CL3B,CR, TX 0.0264 Gins Control Area 2 -New Haz Mat Locations available-listed as Toxic/skin absorptiqn & Inhalation] [Aldrich 147877) [HR: H3 F1 CORI 120 927-58-2 L 100 BromobutyrylChloride (4-) [4-Bromobutanoyl Chloride] [FP 196oF; BP 101oCJ [HR: CL3A, CR, WRt 0.0011 Gins CLV Control Area 2 -New Haz Mat Locations. H3F2R1'CORWR] 121 74-96-4 L 100 Bronioethane [Ethyl Bromide] [Halon 2001] [MP-119oC; BP 37oC/760mm; FP-FL 1A, IR, OHH 0.0264 Gins y FLV Control Area 2 -New Haz MafLocatlons 1 OoF) [LEL 6.75; UEL 11.25] [SG 1.46; Vl13.75] [RTECS#.KH6475000] [HR: H? F3] 122 6482-24-2 L 100 Bromoethyl Methyl Ether (2-) [BP 40oC; FP 83oF; SG 1.479 [Aldrich 238155] [HR: FL1C, IR 0.0110 Gins y Fl.:V Control Area 2 -New Haz Mat Locations H2F3] 123 33884-43-4 L 100 Bromoethyl-1,3-Dloxane (2-2-) [FP 206oF: BP 68oCJ [Aldrich 269131] [HR: H2 F-1] CL3B, IR 0.0220 Gins Control Area 2 -New Haz Mat Locations 124 2576-47-8 s 100 Bromoethylamine Hydrobromlde (2-) [MP 172gC] [RTCS# KQ8225000] [HR: H2] IR 0.4405 , Lbs Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 8 --~ f"-1.J,{ ~ ,... ~~-·--~ ·,, ... ··-·,---·-'? .... :;; --! ~ .. --=-~_.:;.w----...... , -·· ~ => ~ :.: -·-~---,--·- -Isis Pharmaceuticals/ibis Laboratory -1891 Rutherford, Carlsbad CA -C~>ntrol Area 2/Labs: Hazardous Materials Inventory 1teiti. : ~As#:';:;. / :-. : s~te.<c:,o~~~ Material . ,. ... : _. , . .~ .... Hazard Class · Storage, Units Cabs LEV Location. 125 4224-70-8 s 100 llromohexanolcAcld (6-) [MP 33oC; BP 165oC/20nim; FP 154oFI [Aldrich·150452] CR FS [HR: H3 F2 CORI . 0.2202 Lbs Control Area 2 -New Haz Mat Locations -------------------------------------------~---------~~-------------------------······-·------------- j 26 100-39-0 127 580-13-2 128 15018-62-9 129 598-72-1 130 553-94-6 131 4595-60-2 ' m 2951.91.a 133 51-20:7 134 584-93-0 135 108-30-5 136 110-63-4 131 2386-60-9 138 71-36-3 139 1609-86-5 L L s L L s L s L s L L L L 100 Bromomethyl Benzene {a-Bromotoluenel [1;3romophenylmethanel [Benzyl Bromide) CL3A, CR, OHH [FP 189oF; MP -3oC] [HR: H2 F3 CORI. 100 Bromonaphthalene (2-) [BP 281oC; FP·>230oF] [HR: H2 F1] CL3B, IR 100 Bromoorotlc Acid (5-) [MP >70oF] [HR: H2 CORI CR 100 Bromopropionlc Acid (2°) [BP 203oCll60mm; FP 212oF] (Aldrich 878300) [HR: H3 CR, CL3B F1 CORJ . ~ 100 Bromo-p-Xylene (2-) [MP 9o; BP 199oC; FP 175oF] [Aldrich 167266) [HR: F2 H2) CL3A, IR 100 Bromopyrimldine (2-) [MP 71oC] [Aldrich.S462179/Rare Chemical) [HR: H1) IR 100 Bromobimethyfsilane [Trimethylbromosilane] [Trimethylsilyl Bromide) [BP 79oC; FP CR, FL 1C, TX, 90oFJ[SG 1.05) [Aldrich 194409-stabfflzed w/copper](HR: H2 F3 R2 CORWR) WR2 100 Bromouracil (5-) [MP >300oC) [Aldrich 852473) [HR: H2] IR,OHH 100 Brof110valericAcid (2·) [BP 132o/25mril; FP >230oF] [LD50-O: 380 mg/kg) [RTECS# CL3B, CR, TX YV6191500] [HR: H3 F1. COR] 100 Butanedloic Anhydridll (Succinic Anhy(jrlde] [Succinic Acid Anhydride) [LD50-O: 1,510 mg/kg) [RTECS#WN0875000) [HR: H2 R1 WR) 100 Butanedlol (1,4-) [BP 230oF; FP >230oF) [RTECS# EK0525000) [HR: H1 F1] IR, OHH; SN, WR1 CL38,IR 100 Butanesulfonyl Chloride (1-) [BP 809C; FP 175oF] [RTECS# EK5950000) [HR, H3 CL3A, CR, OHH F2COR) 100 Butanol (1-) [Butyl Alcohol] [MPA 1075) [MPA 1075] [FP 95oF; BP 244oF) (SG: 0.81; FL 1G, IR; OHH VD: 2.6; VP: 7) [LFL: 1.4; UFL,: 11.2) [LD50-0 790 mg/kg; LD50-S 3400 mg/kg; LC50 >16,000 ppm) [RTECS# EO1400000) [HR: H2 F3) 100 Butyl Isocyanate (tert-) [BP 51.8oF; BP 85oC) [SG 0.844) [RTECS# NQ8250000) (Aldrich 14452-Listed as Toxic -No LC/LD50 data available] [HR: H3 F3) FLlB, IR, OHH, SN,TX 0.0220 Gins 0.0660 Gins. 0.0066 Lbs 0.0110 Gins 0.0550 Gins 0.0550 Lbs 0.0550 Gins 0.0550 Lbs 0.0550 Gins t1013 Lbs 0.0661 Gins 0.0550 Gins 0.5680 Gins 0.0011 Gins CLV · Control·Area 2-New Haz Mat Locations Control Area 2 -New H.az Mat Locations C9ntrol Area 2 -New Haz Mat Locatio~s Control Area 2 -New Haz Mat Locations CLV Control Area 2·-New Haz Mat Locations Y FLV Control Area 2 -New Haz Mat Locations Control Area 2 -New. Haz Mat Loca!ions Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -·New Haz Mat Locations Centro! Area 2 -New Haz Mat Locations CLV Control Area 2 -New Haz Mat Locations Y FLV Control Area 2 -New Haz Mat Locations Y FLV Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventllatlon required for Class I, II and Ill-A Liquids use-open conditions. CLV.Combustlble Liquid Vapor. FLV-Flammable Liquid Vapor. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Ml!SS Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophbrics: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001-PAGE 9 - - ri-~ v.:aa ~' __ ~ ~ l ~E~-~~~· .-, . .-.. ,. __ .. ~ 11111.· .. ; -'.· --'I -: -:---: --------~ ------.--· ,.,)~ . ~-.. ~- Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Carlsbad CA -Contrql Area 2/Labs: Hazardous Materials Inventory Hen,· -c~1f-: > '. · '~ta_t~~;;~~~o/~~0-:; '.:.··.,· . .-, ,_::· .. :._ '.', ;·-;\,:i, :·Hazard~liass ·_· · ·storage Units Cabs LEV Location 140 109-?a:9 L -100 Butylamine (n-)[BP 78oC; FP 6oFJ[LEL 1.7; UEL 9.8J[SG 0.74; VD 2.5) [LD50-O CR, FL1B, TX 366 mg/kg; LD50-S 850 mg/kg] [RTECS# EO2975000] [Aldrich W3130Q9] {HR: H3 F3COR] 0.2752 Gins 141 98-73-7 S 100 Butylbenzolc Acld.(4-t-) [TBBA] [p-tert-Butyl Benzolc Acid] (HR: H2) IR, OHH ().2202 Lbs Y FLV ControJ Area 2 -New Haz Mat Locations . ----------- Control Area 2 -New Haz Mat Locations -----~~-----------------------------------------------~----··-····· 142 870-46-2 S 100 Butylcarbazate (tert-) [MP 39oC; BP 65oC/0.3mm; FP 197oE] [Aldrich 801005) [HR: FS, IR 0.2202 Lbs 143 18162-48-6 144 109-72-8 145 57260-73-8 • 146 58-08-2 147 471-34-1 148 10043-52-4 149 124-38-9 150 75-15-0 151 56-23-5 152 9001-03-0 153 530-62-1 154 534-17-8 s L L s s s ·CG L L s s s H2F1) 100 Butyldlmethylsilyl Chlciride (tert-) [tert-Butylchlorodimethylsiiane] [MP 86oC; BP 125oC; FP 73oF) [RTECS# W2000000][HR: H3 F2 R1 COR) CR,FS, WR1 </=25 Butyllithium [Solution in Hexanes or Pentane] [BP -57oC to-21oC; FP-7oF to 10oF] CR, OHH, PY, WR2 [Aldrich 230715, 230707, 188171, 302104) (HR: H3 F4 R2 CORWR] 100 Butyl-N~2-Amin~thyl)Carbamate (tert-) (N-Boc-ethylenediamine] [BP 72oC; Fi> >230oF][Aldrich 419923] [HR: H1 F1) 100 Caffeine [lO50-0ral: 192 mg/kg) [MP 234oC] [RTECS# EV6475000] [HR: H3] 100 Calcium Carbonate [Marble Chips) [MP 800oC] [RTECS# FFl!335000) [HR: H1] CL3B, IR IR,.OHH,TX IR 100 Calcium Chloride [MP 782oC] [LD50-0 1 gm/kg) {RTECS# EV9800000) {HR: H2) IR 100 Carbon Dioxide [Asphlxlant) [CO21[mw: 44.01) (8.7 ctnb] [RR: H1) NH 100 Carbon Disulfide [Carbon Bisulfide] [MW: 76.13j [BP 46.5oC; FP-22oF; LEL: 1.3%; FL 18, IR, OHH, UEL: 50%] [SG 1.266; VD 2.67) [LD50-O: 3188 mg/kg; LC50: 50 g/L) [RTECS# P65, RMP-T1, FF6650000) [HR:H2 F3)' RMP-T3 100 Carbon Tetrachloride, [Tetrachloromethane] [BP 170oF; FP None) [Aldrich 270652) CA, OHH, P65 [LD50-0 2350 mg/kg; LC50 1600 ppm] [RTECS# FG4900000] [HR: H2] . 100· CarbonicAnhydrase (F) [HR: H1] OHH 100 Car!Jonyldiimldazole (1,1-) [MP 117oC] [Aldrich 115533) [HR: H3 R1 COR) CR,WR1 100 Cesium Carbonate [RTECS# FK9400900] [HR: H1] IR 0.2202 Lbs 0.0881 Gins 1.3767 Gins 0.0220 Lbs . 1.1013 Lbs 7.7093 Lbs 10.0000 Cf 1.3210 Gins 4:0232 Gins 1.3209 Lbs 0.0220 Lbs 0.1322 Lbs y Y FLV Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 • New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New .Haz Mat Locations Control Area.2 -New Haz Mat Locations Control Area-2 -lllew Haz Mat Locations Control Area 2 • New Haz Mat Locations Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount = Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 10 -· ----flllll t_.. w,r· -· ~-~---·:;eJ11 r~.:.111iil_,_ -.._'.."_) _:,,; 111111iJ llliii: -: .. :~------,---- Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory Item :_~~!-'\/-;J<.~.tatei_~qcf.~.½-."~,~~r.f,i _\'-_:0: :·_-• \'·_\ ·_ 'f .'· -< ':, . '· ··/ _<-._-: ·_ .. _._,. __ ._: · ·:;, .: .. \~~r~_Ci~~-:_-. ··:°'Stqr,111e: _l:Jnlt~. : ~abs· LEV Location 155 · 57-09-0 S. 100 Cetyltrimeth~rnmonlum Bromide [He~adecyltri~thylammonium B·romlde] CR,OHH,TX 0.2202 Lbs Control Area 2 -New Haz Mat locations [Cetrimonlurn Bfl)mlde) [CTAB] [MP 2480) [L050-0: 410 mg/kg) [RTECS# BQ787500] [HR: 1;13 COR] 156 82473-24-3 s 100 CHAPSO [3-{(3QCholamldopropyl)-Dimethylammonio}-1-Propanesulfonale] [MP IR 0.0066 Lbs Control Area 2 -New Haz Mat Locations 184oC] [Aldrich 374237,] [HR: H2) 157 118-97--8 s 100 Chloro-3,5-Dlnilrobenzotc Acid (4-) [MP 159oC] [Aldrich C38907) [HR: H1] IR 0.2202 Lb!; CQntrol Area 2 -New Haz Mat Locations 158 38818-50-7 s 100 Chloro-3-Nitrobenzoyl Chloride (4-0 [MP 52oC; FP >230oF] [Aldrfch 528641] [HR: CR,OHH 0.0550 Lbs Control Area 2 -New Haz Melt Loq3tlons H3COR] --- 159 5381-99-7 s 100 Chlo~H-1,3,2-Benzodloxaphosphorin-4-one (2-) [HR: H3 COR] CR,SN 0.0220 Lbs Gonlrol Area 2 -New Haz Mat Locations 160 100-00-5 s 100 Chloro-4-Nilrobenzene·(1-) [p-Amlnonilrobenzene] [Nondetonatable] [MW: 157.56[ CA, FS, IR, OHH, 0.2202 Lbs y Control Area 2 -New. Haz Mat Locations [MP 83oC; FP 110oF] [LD50-O: 420 mg/kg; LD50-S: 16 glkg) [HR: H3 F2 R3) TX-,UR3,P65 161 621-62-5 L 100 Chloroacetaldehyde Diethyl Ace!l:11 [2-Chloro-1,2-Diethoxyelhane] [FP 85oF; BP CR; FL1C, WR1 0.0220 Gins y FLV Control Area 2 -New Haz Mat Locations 157oC; SG 1.108][Akfric'1 C19201] [HR: H3 F3 R1 COR WR1) -~ 162 10~-lJ(l:7 L 100 Chlorobenzene [Phenyl Chloride] [Monochlorobenzene] [MP -45oC; BP 132oC; FP FL 1C, IR, OHH 0.5283 Gins y FLV Control Area 2 -New t-!az Mat Locations 75oF] [LFL 1.3; llFL 7.1] [SG 1.106; VD 3.86] [LD50-01110 mg/kg;·LC50 2965 ppm] [RTECS# CZ0175000] [HR: H2 F3] 163 1210-33-9 ·S 100 Chlor'odibenzosuberane (5-) [5-Chloro-10, 11-Dihydro-5H-Dibenzo(a,d)Cyclohepiene) IR 0.0550 Lbs Control Area 2 -NewHilz Mat Locations [MP >1060) [RTECS#H08302000) [HR: H1J 164 67-66-3 L 100 Chlorofonn [TJichloromethane] [CHCL3) [LD50-Oral: 908 mg/kg) [MP -630; BP 61oC; CA, IR, OHH, P65, 26.9985. Gins Control Area 2 -New·Haz Mat Locations FP None) [LD50-O 605 rilg/kg; LD50-S >20 gm/kg; LC50 57,702 PP.m] [RTECS# RMP-T1, RMP-T3 FS9100000] [HR: H3] 165 2942-59-8 s 100 ChlororiicotlnicAcid (2-) [MP :;,175oC] [Aldrich 150339] [HR: H2] IR 0.0220 Lb.s Co[ltrol Area 2 -New Haz Mat Locations 166 937-14-4 s 100 Chloroperoxybenzoic Acid (3-) [MCPBA) [3-Chloroperbenzolc Acid] [MP 69oC] IR,OP3,UR2 0.0550 Lbs Control Area 2 -New Haz Mat Locations [RTECS# SD9470000] [HR: H2 F2 R2) 167 13010-19-0 L 100 Chloropropyl Isocyanate (3-) [FP 143oF; BP 1520] [HR: H2 F2 R1] CL3A, IR, WR1 0.0110 Gins CLV Control Area 2 -New Haz Mat-Locations 168 6276-54-6 s 100 Chloropropylamine Hydrochloride (3-) [MP 148oC] [HR: H1) IR 0.1101 Lbs Control Area 2 -New Haz Mat Locations --------·-· - LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount = M~xlmum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% in use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 • PAGE 11 - -:.: .. -·-·-r-~ .. ~ .,"'" .. '¥.....,·'' ... ,.._ ·--. -,, -·r -·, --. --· -,£;;_,~~ ...... -=; ____ ; _.:,_ ~...; 41 • ' .,_ -:, __ -·.--~-- Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory ltem: .. ¢AS#:"°t>,-\state :-ion~WtMaterlal .; ·; .:_'·',:,: ·:: :,. ··:~ . ' :-· ' ',.:' '... :.:;·· ··.·Hazard Class· .... , Sforage~_-'Unlts, Cabs LEV Location •• ;__~_. _._· _:;_,.:...:_ _ _: -•: .. • .. ,'-.!__~_,__,, __ ..... _,._";___.: ___ :-·---~-·-:-···. ••• ,: __ ._ ·----•• • ., ....... . 169 75-77-4 L , 100 Chlorolrimethylsilane [TrimelhylchlorosilaneJ [TMSCI] [BP 57oC; FP -18oF] [VD 3.7; CR, FL 1B, OHH, 0.5284 Gins Y FLV Control Area 2-New Haz Mat Locations SG 0.859] [LEL 2;·UEL6].4 [LD50-0: 5660 mlcrograms/kg; LD50-S: 1780 TX, WR3, RMP-T1, micrograms/kg] [RTECS# VV2710000] [HR: H3 F3 R3 COR WRJ RMP-T3 -------~-----------~----------------------------··------. ---·--·-·-- 170 · 10049-05-5> s 171 1138-15-4 · s 172 4392-24-9 s 173 77-92-9 s 17 4 5949-29-1 s 175 7646-79-9 s 176 7646-79-9 • S 177 7787-70-4 s 178 7758-98-7 ·s 179 922-32-7 s 180 294-93-9 L 181 420-04-2 s 182 767-00-0 s 183 1122-82-3 L 100 Chromium(il) Chloride [MP 824oC] [RTECS# GH5250000] [HR: H~ R1] 100 Cinnamoylimldazote (1°trans-) [MP 133oC] [Al<lrk;h ~19045] [HR, H1 R1] CA,IR,OHH, WR1, P65 IR, UR1, WR1 100 Cinnamyl Bromide [3-Sromo-1-Phenyi-1-Propene] [MP 29oC; BP 103oF/22mm; FP CR, FS 190oF] [HR: F1 H3 COR] 100 Citric Acid [MP 15ioe1 [C6H807] [RTECS# GE7350000] [HR: H1] IR 100, Citric Acid Monohydrate [RTECS#, GE7810000f [HR: H1] IR 100 Cobalt(ii) Chloride [L050-0: 80 mg/kgj [RTECS# GF9800000] [MP724o] [HR:·H3] CA, IR, OHH, SN, TX 100 Cobalt{ii) Chloride [LD50-0:·80 mg/kg] [RTECS# GF9800000] [MP 7240] [HR: H3) CA, IR, OHH, SN, TX 100 Copper(!) Bromide [Cuprous Bromide] [Aldrich 254185] [HR: H2 R1J 100 · Copper(II) Sulfate [Cupric Sulfate) [MP 200oC] [LD50-0ral: 300-960 mg/kgj [RTECS# GL8800000] [HR: H3] IR;WR1 IR,OHH,TX 100 C::reati.ne Phosphate Dlsodium Salt Telrahydrate [Sodium creatine phosphate dibasic IR tetrahydrate] [pH 7.7-8.7] [Fiuka 27920] [HR: H1] 100 Crown-4 (12-) [1,4,7,10-Tetraox;icyclododecane] [BP 61oC; FP >230oF] [RTECS# CL3B, IR, OHH XF0550000] [HR: H2 F1] 100 Cyanimide [LDS0-0125 mg/kg; LD50-S 590 mg/kg] [MP 45oC; FP 2856F] [RTECS# CR, TX, WR2 GS5950000] [HR: H4 R2 COR·WR] 100 Cyanophenol (4-) [4-Hyd_roxybenzonitrileJ [MP 110oC] [LDS0-0: 450 mg/kg] [RTECS#Dl4375000] [HR: H3] IR, TX 100 Cyciehexyl lsothiocyanate [BP 2190; FP 204oF] [RTECS# NX8480000] [HR: H2 F1 Cl3B, CR COR] 0.0550 lbs ,Control Area 2 -New Hai: Mat locations 0.0110 Lbs Control Area 2 -New Haz Mat locations 0.0550 Lbs Control Area 2 -New Haz Mat locations 1.1013 Lbs Control Area 2 -New Ha~ Mat locations 1.1013 lbs Cqntrol Area 2 -New Haz Mat locations 5.0000 tbs Control Area 2 -New Haz Mat locations 0.2202 Lbs Control Area 2 -New Haz Mat locations 0.0220 lbs Control Area 2 -New Haz Mat Locations 0;2202 lbs Control Area 2 -New Haz Mat locations 0.0110 Lbs Control Area-2 -New-Haz Mat locations 0.0022 Gins Control Area 2 -New Haz Mat Locations 0.4405 Lbs y Control Area 2 -New Haz Mat Locations 0.2202 Lbs Control Area 2 -New Haz Mat locations 0.0550 Gins Control Area 2 -New Haz Mat Locations -----------------------------------------------------------------------------------------·--·-·- LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. , Storage Amount= Maximum/total amount in use and.storage, unless otherwise noted. Not all materials are in use at.the same time, with <10% In use at any time .. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114·& L117. Existing Haz M'at Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic. fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 • PAGE 12 - --~f---~ ~ ·~· . ~~-f~:' $-"~--1::j ··:.·:ma ;-··: -·, 111111] _,. -.. --...,.:~',i:f;'... :.!,:..oc • ' '"<:::o'¼: -~-; 1 -. ---,,,,. .. ~ -• : • --····- Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Carlsbad CA -Control Area 2/Labs: Hazardous Materials Inventory _:,_.· .... ~--·,·-._. :-.. -;·-: ~.... ..·.-.c;:-_:·.:.;: ·.' •.: ··· .. ,' · Item· CA$1t. : _. , .. State. Conc"le ·Material,.·.·:·.,._.,_.-. · ··. ,; , , . .,Hazard Class .. _; _;._._~·-· ·. ~ ' ... ;. :· ·--~ ·._ .. '·:·:: .. , . . . 184 2516-34-9 L 100 Cygk>butylamlne [BP 81.5oC; FP 24oF] [SG 0.833] [Aldrich 225185] [HR: H3 F3 CR, FL 1B CORI · ·Sto~age' .. Units · .~ab~ t,EV 0.0022 Gins Y FLV L~tlon Control Area 2 -New·Haz Mat Locations -~----~------~------------~----------------------------..:.---------· ------·-···--·--- 185 110-82-7 L 100 Cyclohexa~e [MP 6.5oC; BP 80.7oC; FP-1oF] [LEL: 1.3; UEL: BJ [SG 0.779; VD 2.9] FL 1B, IR, OHH [LD50-0 12,705 mg/kg] [RTECS# GU6300000] [HR: H2 F3] 1.7171 Gins Y FLV Control Area 2 -· New Haz Mat Locations -----~---~-~----------~----------~---------------~-----·-··-·----·--- 186 108-94-1 187 930-68-7 188 3173-53-3 189 108-~1-8 190 1135-40-6 191 68-39-3 192 56-17-7 193 9007-43-6 194 71-30-7 195 605-65-2 196 520-45-6 •. 197 302-95-4 L L L L s s s s s s s s 100 Cyclohexanone [BYK-20-, -065 Paint Additive] [LD!i0~O 800 mg/kg; LD50-S 948 CL2, IR, OHH, TX mg/kg; LC50 16,000 ppm] [BP 310oF;·FP 109oF] [RTECS# GW105000Q] [HR: H2 F2J 100 Cyclohexen-1-one (2-) [BP -53oC; BP 164oC; FP 137oF] [LD50-0: 220 mg/kg; LOSO-CL2, HT, IR S: 70 mg/kg; LC50: 250 ppm/4H] [RTECS# GW7000000] [HR: H4F2] 100 Cyciohexyl Isocyanate [lsocyanatocyclohexane] [BP 168oC; FP 120of;] [Aldrich C105198] [RTECS# NQ8650000] [HR: H3 F2 CORI 100 Cyclohexylamine [BP 1340; FP 90oF] [LDS0-O11-156 mg/kg; LD50-S 32 mg/kg; LC50] [LEL 1.5; UEL 9.4] [VD 3,43Z; SG 0.867] [Aldrich 240648] [RTECS# GX070000] [HR: F3 H3 COR] 100 . Cyclohexylamino-1-Piopanesulfonlc Acid (3-)[Cap A, BJ[CAPSJ(RTECS# TZ63950000f[HRt H2] 100 Cycloserine (DL-) [RTECS# NY2974900] [HR, H1) 100 Cystamine Dihydrochloride [MP 2170 dee] [RTECS# KR7260000] [HR: H1] 100 Cytochrome C [RTECS# HA5365000) [HOJSe Heart Muscle] [HR: OJ CL2,.CR, OHH, SN CR,.FL1C, HT, OHH, SN; RMP- T1, RMP-T3 IR IR IR NH 100 Cytosine [4-Amino-2,6-Anhydro-5-Nitropyrfmkliriej [RTECS# UW7350150] [HR: H2) IR 100 Dansyl Chloride[5-Dlmetllylamino-1-Naphthaienesulfortyi Chloride) [MP 72oC) CR; WR1 [Aldrich 0143359] [HR: H3 R1 COR] 100 DehydroaceticAcid [3-Acetyl-6-Methyl-2H-Pyran-2,4(3H)Dione] IR, OHH, TX [Methylacetopyronone] [MP 109oCJ [LDS0-0: 500 mg/kg] [RTECS# UP8050000] [HR:H2] 100 Deoxychoiic Acid Sodium Salt [5b-Cholan-24--0icAcid-3a, 12-a-0iol] [7-Deoxycholic IR Acid] [Desocychoiic Acid] [Fluka 30970] [HR: H1) 0.0025 Gins 0.0066 Gins ·0.0550 Gin~ 0.0264 Gins 0:5507 Lbs 0.0022 Lbs 0.0550 Lbs 13.2086 Lbs 0.4846 Lbs 0.1322 Lbs 0.2202 Lbs 0.2202 Lbs CL V Control Area 2 -New Haz Mat Locations Y CL V Control Area 2 -New Haz Mat Locations CLV Control Area 2 -New Haz Mat locations Y FLV Con!TQI Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locatio.ns Control Area 2 -New Haz Mat L~tions Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations · Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vapor. FLV-Flammable Liquid Vapor. Storage Amount =·Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10•1. in use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Loc1:1tions: BSL-2 Labs/L 115 and L 116, Equip Labs/L120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 13 - .. ---- ----r----:·:[~~~ . -~~~·-~· ~·: -~-~ ... _; 1111] ... , -.. L .. ----.·~--·- Isis Pharmaceutlcals/lbi.s Laboratory-1891 Rutherford, Carlsbad CA-Contr()I Area.2/Labs: Hazardous Materials Inventory Item·· c~t\i-:} .. {:s~t~?¢pn~"%;~~te~a(_;;~:,{//.\:'. ' .. ,.. >: ·: ·. ;·-:. '·.· ._-: -· .. : .:--: · '.Hazard Class .. Storage 'Units Cabs LEV Location . . 198 28150-15-4 s. 100 Diamlnobenzyl Alcohol Dihydrochloride (3,S.:) [MP >300) [Aldrich 213977) [HR: H2] IR 0.0220 Lbs Control Area 2 -New Haz Mal Locations -- 199 373-44-4 'S 100 Diaminooctane (1,8-) [1;8-0ctanediamine] [MP 50oC; FP 225oC; FP 329oF] IR 0.0550 Lbs Coritrol Area 2 -New Haz Mat Locations [RTECS# RG8841500) [HR: H2] ------ 200 109-76-2 L 100 Dlamlnopropane (1,3-) [1,3-Propanediamine] [BP 1400; FP 120oF] [l.D50-0:.350 CL2,CR,TX 0.0534 _ Gins CLV Control Alea 2 -New Haz Mat Locations mg/kg] [RTECS# TX68250000] [HR: H3 F2 COR] 201 6674-22-2 L 100 Diazabicycfo(5.4.0]Undec-7-ene(1,8-) [DBU] (2,3,4,6;7,8,~,10-0ctahydropyrlmldo(2,2-CL3B, CR 0.0440 Gins Control Area 2 -New Haz Mat loca\jons a)Azeplne] [BP 80oCI0.6mm; FP >,230oF] [HR: H3 F1 COR) 202 80-11-5 s 100 Diazald [N-Methyl-N-Nitroso-p-Toluenesulfonamide] [RTECS# XT5950000] [HR: H2] CA, I~, OHH 0.2202 lbs. Control Area 2 -New Haz Mat Locations 203 74-95-3 L 100 Dlbromomethane (1,2-) [Methylene Bromide) (BP 96o; FP None] [LD50-0: 460 IR,bHH,TX 0.1321 Gins Control Area 2 -New Haz Mat locations mg/kg] [RTECS# PA7350000) [HR: H3] ·--- • 204 630-25-1 s 100 Dibromoletr.ichloroethane (1,2-) [MP 220oC] [HR: H1] IR 0.2202 Lbs Control Area 2 -New Haz Mat Locations 205 1034-39-5 s 100· Dlbromotriphenylphosphorane [Triphenylphosphine Dibromide] [HR: 1:13 R1 cbR CR,WR1 Q.0044 Lbs Cpntrol Area 2 -New Haz Mat locations WR] 206 107-06-2 l 100 Dlchloroethane (1,2-) [Ethylene Dichloride] [EDC] [DEC) (EEC] [BP 182<iF; FP CA, Fl 18, IR; 4,2268 Gins y FLV Control Area 2 -New Hat Mat locations 55.4oFl Al: 775oF] [LEL1 6.2.; UEl: 15.9] (SG 1.256; VD 3.4] (LD50-0 670 mg/kg) OHH,P65 [Sigma 48509) [RTECS# KI0525000] (HR: H3 F3) 207 5398-44-7 s 100 Dichlorolsonicotinic.Acid (2M [MP >209oF) [Aldrich 456543] (HR: H2] IR 0.0110 lbs Control Area 2-NewHaz Mat Locations 208 75-09-2 L >/=70 Dichloromelhane [Methylene Chloride] [Methane Dichloride] [Freon 30] [BP 104oF; CA, CR, OHH, P65 8.0000 ·Gins Control Area 2 -New Haz Mat Locations FP None] [LD50-0 1800 mg/kg) [RTECS# PA805000) [HR: H3 COR]· 209 141-30-0 s 100 Dlchloropyridazone (3,6-) [MP 66oC) [l.D50-0 >50 mg/kg; LC50 >2,POO ppm) IR,TX 0.0055 Lbs Control Area 2 -New Haz Mal Locations [RTECS# UR5886250] [Aldrich D73200] [HR: H2) 210 4342-61-4 L 100 Dichlorotetramelhyldlsilane (1,2-) [BP 148oC; FP 99oF; SG 1.005) [HR: H3 F3 R2 CR, FL 1C, WR2 0.0066 Gins y FLV Control Area 2 -New Haz Mat Locations CORWR] - 211 20039-33-2 L 100 Dielhoxyphosphlnyl Isocyanate (Diethyl Phosphorisocyanatjdate] [BP 85oC; FP CL2, IR, SN, WR1 0.220? Gins C:V Control Area 2 -New Haz Matlocations 119oF] [Aldrich 369780] [HR: H2 R1) 212 13433-00-6 s 100 Diethyl Amlnomalonate Hydrochloride [HR: H2) IR 0.2202 Lbs Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for' Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excludlng Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophbrics: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 14 -- ~ , .. _ 7;;:::,-..... .,.,, .• ~· r.:_.-. ~iili,;· -., ___ , ___ ..... > ••• , ... -··· ...... '.j -· -,__ --- %'7->. ·-~~__:,.--• '~-~ _._ •• : ----: • ..J ~ : ~ ~ . ~ ,,, .• Isis Pharmaceuticals/Ibis Laboratory-1891 Rutherford, Carlsbad CA-Control Area 2/Lab~: Hazardous Materials Inventory .. Hem CAS#·: .:· ..... · · State:. Cone% · Material · · '• . ti~,;ard Class · Sto~ge Units Cabs LEV Location . -. ., '·-' . . . ~ ~ . ' : . . . :~. .. . ' . . , . 213 1972-28-7 L . 100 Diethyl Azodicarboxylate [DEAD] [Diethyl Azoformate] (1,2-Diethoxycarbonyldiazene] C~3B, iR, OHH, 0.0980 Gins Control Area 2 -New Haz Mat Locations [BP 106oC; FP >230oF) [Shock Sensitive) [Aldrich D90008l[HR: H2 F1 R2J UR2 --·-··----- 214 20605-01-0 s 100 Diethyl Bis(Hydroxymethyl)Malonale [MP 49oC; FP >230oF) (Aldrich 298358) (HR: 18 0,.0022 Lbs Control Area 2 -New Haz Mat Locatiims H2] l15 10344-69-1 s 100 Diethyl Malonimidate Dihydrochlorfde [MP 122oCJ [HR: H1] IR 0.0550 Lbs Control Area 2 .-New· Haz Mat Locations 216 109-89-7 L 100 Dlethylamlne [DEA) [MP-50oC; BP 55oC; FP -20oF).[LFL 1.8; UFL 10.2) [VD 0.707; CR, FL 1B,.SN 0.0220 Gins y FLV Control Are~ 2 -New Ha.z Mat Locations SG 2.531] [RTECS# HZ8750000J (HR: H3 F3 CORI 217 1609-47-8 L 100 Dlethylpyrocarbonate (Diethyl.Oxydiformate) [Diethyl Pyrocarbonate) [DEPC] [DEP) CL3A, IR, OHH 0.0066 Gins CLV. Control Area 2 -New Haz Mat Locations [RTECS# LQ9350000] [BP 160oC; FP 158:2oF) [LDS0-0: 850 mg/kg] [RTECS# LQ9350000] (HR: H2 F2J 218 110-87:2 L 100 Dlhydropyran [3;4-Dihydro-2H-Pyran][BP 86oC; FP 4oFJ [LEL 1.1; UEL 13,8] [SG FL1B, IR 0.0220 Gins y FLV Control Area 2 -New Haz Mat Locations 0.928; VD 2.911) [Aldrich D106208] (RTES# UP7700000) [HR: H2 F3] 219 1191-15-7 L </=50 Dilsobutylalumlnum Hydride [1:0M Solution in Hexanes, Tetrahydrofuran-orToluene] CR, OHH, PY, WR2 0,0528 Gins ,Y Control Area 2 -New Haz Mat Locations [DIBAL-H] [BP 11f?DC/1mm: FP >/=-10oF] [RTECS# 8D0710000) [HR: H3 F3 COR R2] 220 2446-83-5 L 100 Dilsopropyl Azodicarboxylate [BP 75oC: FP 223oF)[Aldrich 225541 -listed as a CL3B, IR; OHH 0.0220 Gins Control Area 2 -New Haz Mat Locations llguld] [HR: F1 H2] ,. _________ .,.. __ 221 108"18-9 L 100 Diisopropylamine [N-(1-Methylethyl)-2-Propanamlne] [BP 84oC; FP 21oF) [LEt: 1.1; CR, FL 18 0.6000 Gins y FLV Control Area 2 • New Haz Mat Locationl! UEL: ~.5] [SG 0.722; VD 3.5) [RTECS# IM4025000] [HR: H3 F3 CORJ 222 693-13-0 L 100 Diisopropylcarbodilmlde (1,3-) [BP 145ciC; FP 93oFJ [SG 0.806]; vp 4.368 [LDSo:o: FL 1C, IR, HT, SN, 0.0220 Gins y FLY Control Area 2 -New Haz Mat Locations 36 n,g/kg; LC50: ~025 ppm/4H] [RTECS# FF2175000] [Coupling Reagent for WR1 Peptide Syntheses] [HR: H;3 F3] 223 7087-68-5 L 100 Dlisopropylethylamlne (N,N-) [Diethylisopropylamine] [Ethyldiisoproylamine(N,N-)1 CR,FL1B 1.5000 Gins y FLV Control Area 2 -New Haz Matlocatlons [DIPEA] [BP 127oC; FP 51oF) [SG 0.742; VD 4.472] [RTECS# IM4025000] [H~: H3 F3CORJ 224 1131-62-0 s 100 Dimethoxyacetophenone (3',4'-) [MP 51oC; BP 286oCll60mm; FP >230oF] [Aldrich IR 0.0550 Lbs Control Area 2 -New Haz Mat locations 156639] [HR: H1] 225 120-14-9 s 100 Dimethoxybenzaldehyde (3,4-) [Veratraldehyde] [MP 42oC: BP 281oCll60mm; FP IR 0.2202 Lbs Control Area 2 -New Haz Mat Locations >230oF] [Aldrich 1-13758] [HR: H2] LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage.Amount=:= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding.Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation 9f dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS • ERIKSEN-RATTAN-ASSOCIATES INC. • 11/13/2001 • PAGE 15 - -·-.. ·-¥Pt ,•;:,·~-·~ , ...... _. ·;-·, ···-··1 -·'s; {_ ~!-:-' ~~\~~6-:. ... ,,....,.. .... ~ _____ ! ,,_:_j .... ~ ~ -·: --:·---- Isis Pharmaceuticals/Ibis Laborc:1tory-1891' Rutherford; Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory ·. 1ten\( c~~--: .. _:,:.'::jt~i,\ c_~iic~i:·,._~teri~i-.. i ·\'· // :/.:. /:··. ,: <.:. · 1,• ., : ': . :-}, ._: :Hazard Class\ ' Storage .... Unlts . Cab~ LEV Location ,, . . . . . .. ' ·. . . : ~· . 226 93-03-8 L· 100 Dimethoxybenzyl Alcohol (3,4-) [Veralryl:Alcohol) [BP 296o; FP >230oF] [HR: H1 F1) CL3B,.IR 0.5000 Gins Control Area 2--New Haz Mat Locations 227 3600-86-0 L 100 Dlmethoxyphenethylamlne (2,5-) [BP 160oC; FP >230oF] [Aldrich 357677] [HR: H2 CL38, IR 0.1652 Gins Control Area 2 -New Haz Mat Locations F1] -------- 228 77-76-9 L 100 Dlmethoxypropane (2,2-) [Acetone Dimethyl A~talj [FP 12oF; BP 8~oCJ [LDL 6; FL1B,IR 0.2642 Gins y FLV ~ontrol Area 2 -New Haz Mat Locations UEL 31J [SG 0.847; VD 3.59] [Aldrich D1~6803J [HR: H2 F3J 229 40615-36-9 s 100 · Dlmethoxytrityl Chloride (4,4'-) [4,4'-DimethoxytriphenylmethyJ Chloride) [MP 119oC] IR, WR1 2.2026 Lbs Control Area 2 -New Haz-Mat Locations [Aldrich 100013) (HR: H2 R1] ··----·----- 230 77-78-1 L 100 Dimethyl Sulfate [Methyl Sulfate) [MP -320; BP 1889; FP 182oF) [LD50-0: 205 CA, CL3A, CR, 0.0220 Gins CLV Control Area 2 -New Haz Mat Locations mg/kg; LC50: 90 mg/I.] [RTECS# WS8225000) [HR: H3 F2 R1 COR WRJ OHH, TX, WR1, P65, RMP-T3 231 67-68-5 L 100 Dimethyl Sulfoxlde [DMSO] [Methyl Sulfoxide] [RiboGreen-Component B [PicoGreen-CL3B, IR, SN 10.6417 Gins Control Area 2 -New Haz Mat Locations Component A) [PlcoGreen] [FP 203oF; BP 3720FJ [LD50-0: 14,500 mg/kg) [RTECS# PV6210Q90) [HR: H2 F1) 232 67-68-5 L 100 Dimethyl Sulfoxide [DMSOJ [Methyl Sulfoxi~eJ [RiboGreen-Component B [PicoGreen-CL3B, IR, SN 0.0528 Gins Control Area 2 -Existing Haz Mat ComponentAJ [P!<xJGreen) [FP 203oF; BP 3720F] [LDS0-0:.14,500 mg/kg}-LC>Cations [RTECS# PV6210000] (HR: H2 F1J 233 86-56-6 L 100 Dlmethyl-1~Naphthylamlne (N,N-) (1-Dirnethylamlnonaphthalene) [BP 139oC; FP . CL3B, IR, OHH 0.1585 Gins Control Area 2 -New Haz Mat Locations >230oF) [RTECS# QM2825000J [HR: H2 F1] .234 127-19-5 L 100 Dimethylacetamlde (N,N-) [DMAC) [BP 164oC; FP 158oF) [RTES# AB7700000) [HR: CL3A, IR, OHH 1.1000 Gins CLV Control Area 2 -New Haz Mat Locations H2F2) 235 124-40-3" LG 100 Dimethylamine [LD50-0 696 mg/kg; LC 5011,118 ppm) [rnw: 4~. 10; 8.5144 cf/lb) CR, FG, PSM, ,, 10.0000 Cf Control Area 2 -New Haz Mal Locations [LEL 2.8; UEL 14.41 [SG 0.938; VO 1.56; VP 31) [RTECS# IP8750000) [HR: H3 F4 RMP-T2 CORJ 236 124-40-3 ,. L </=50 Dimethylamine [Solution in Methanol, Tetrahydrofuran or Water! [BP 60oC; FP-33oF CR, FL1B, OHH, 0.052~ Gins y FLV Control Area 2 -New Haz Mat Locations to 41oF) [l.050-0 696 mg/kg; LC 50 11,118 ppm] [mw: 45.10; 8.5 cf/lb) (LEL 2.8; SN UEL 14.41 [SG 0.938; VD 1'.56; VP 31] [RTECS# IP8750000J [HR: F3 H3 CORI 237 109-55-7 L 100 Dirnethylaminopropylamlne (3-) [BP 133oC; FP 60oF] [SG 0.812; VD 3.6] [LFL 3] FL1B, CR 0.0132 Gins y FLV Control Area 2 -New Haz Mal Locations [LD50-0 1870 mg/kg) [RTECS# TX7525000) [HR: H3 F3 CORJ LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10o/o In use at any tlnie. Control Area 2: EnU!'e building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyropliorics: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fi~e sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 16 -· - -.. mi11111111a ···-· m;·~;-,;:;,•;',:'-~ .. , . .,.,..__ ., :"·, _ ..... ......,,1 .r~· t_-: ~ ....... ~~$ ... -J ~ .... J :. ~ ~ ......,:., 11111 -:,_ ::,_ .......... ····---· Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherfc;,rd, Carlsb;!d CA -C:ontro! Area 2/Labs: Hazardous lillaterials li:,ventory Item . ~~':?:"·.-:f\~tat_~:;,,#0~~%_,::"~f,i~ri~i \/? !·:,\\ ./ ,; >:, ··i::i: . .' '· '·· · · _, ..... · .. .-:--::. /·i· ._ ... "> ·. · H~ar~ ~lass:-;:- 238 1122-58-3 S . 100 Dimethylamlnopyridine (4-) [4:{Dimethylamino)Pyriiline] [MP 112oC] [LDq()-0: 470 CR, TX mg/kg] (RTECS# US9230000] [HR: H2 COR] ~~~~ge_ : Uni~ ; Cabs . LEV 0.4405 Lbs Location Control Area 2 -New Ra~ Mat Locations · · -----------------------------'-------~--------------.,.--------~-----------··-·----·- 239 6.8-12-2 L 100 Dimethylfonnamlde (N;N-) [DMF] [pH: 8) [MP-61oC;FP 126oF; BP 153oC) [L0~0-0 CA, CL2, IR, OHH 2800 mg/kg; L050-S 4720 mg/kg; LC50 >18,800 ppm] [RTECS# lQ2100000] {HR: H3F2) 10.0000 Gins CLV · Control Area 2 -New Haz Mat Locations ---------------------------------------------~----------------''----~---------------------·-- 240 996-35-0 241 51200-87-4 242 528-76-7 243 1656-44-6 244 177-11-7 245 123-91-1 246 1666-13~ 247 26386-88-9 248 74124-79-1 249 117924-33-1 250 24424-99-5 -·· 251 27565-41-9 L L s s L L s L s L s s 100 Dlmethyllsoproylamlne (N,N-) [BP 65.5oC/752mm: FP 15oF; SG 0.715) [Aklrich 343986) {HR: H3 FB COR] FL1B,.CR </=75 Dimethyloxadolldlne (4.4') [FP 120oF; SG 0.942) [LD50-0 950 mg/kg; LD50-S 1400 CL2, IR, TX mg/kg] [Aldrich 41n85) [RTECS# RP9100000] [HR: H2 F2] 100 Dlnltrobenzenesulfenyl Chloride (2,4-) [2,4-DinitrophenylslMenyl Chloride) [MP 94oC] CR, WR1 [Aldrich 105457) {HR: H3 R1 COR WR) 100 Dinltfol?enzenesulfonyl Chloride·(2,4-) [MP 102oC] [Aldrich 142956) {HR: H3 R1 CORI 100 Dloxa-8-Azaspriro[4,5)Decane (1,4-) [4-Piperidone Ethylene Ketal] [BP 108oC/26mm; FP 179oF] [Aldrich 178365) [HR: H2 F2] 100 Dloxane (1i) [1,4-Diethylene ~Ide) [BP 100oC; FP 54oF] [LEL 2; UEL 22] [SG 1.034; VD 3.049] [LD50-0 4200 mg/kg] [RTECS# JG8225000] !HR: H3 F3] CR,WR1 CL3A,IR CA, FL 1B, IR, QHH,P65 100 Dlphenyl Diselerilde [Phenyl Diselenidel[Bls(Phenyiselenlde] [MP 63oC) {HR: H2] IR, OHH 100 Diphenylphosphoiyl Azlde [BP 157oC/0.17mm; FP >230oF] [Aldrich 104760] [HR: Ct3B, IR; OHH H2F1) 100 Dlsuccinlmidyl Carbonate (N,N'-) [MP 190oC] [HR: H1) 100 01-tert-Butyl Diethylphphosphoramidite[BP 39oC; FP 173oF] [SG0.896] [Aldrich 365963] [HR:.H2 F2 R1 WR] IR CL3A, IR, WR1 100 Di-tert-Butyldicarbonate [di-tert-Butyl Pyrpearbonate] [!-BOC Anhydride] [MP 23oC; FS, IR, UR2 BP 56oC; FP 99oF] [Aldrich 361941] [HR: H2 F2 R2] 100 Dithiothreitol [Cleland's Reagent] [DTT] [dl-DTT] [Threo-1,4-Dimercapto-2,3- Butanedloi) [DTT] [MP 41oC; FP >230oF] [Ludferase Assay Substrate] [Aldrich 150460] [RTECS# X08576500] [HR: H2) IR,OHH 0.0661 Gins 0.2642 Gins 0.2202 Lbs 0.1617 Lbs 0.0220 Gins 8.1894 Gins 0.0550 Lbs 0.0220 Gins 1.1013 Lbs 0.0110 Gins 0.2202 Lbs 0.0330 Lbs Y FLV Control Area 2 -New Haz Mat Locations CLV Control Area 2 -N~ Haz Mat Locations Control Area 2 -New Haz,Mat Locations Control Area 2 • New Haz Mat Locations CLV Control Area 2 -New Haz Mat Locations Y Fl:.V Control Area·2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations 'CLV Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations LEV: Local·or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount== Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% in use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. · Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 CombustlbJe Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. PyrophDrics: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. · HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 17 \ -·· -_, .. L111111 ~~ r1~r .... _.,_. --·-,. ---· :~...,_ ___ _j __ _,: .v~ -j -: -:-. :~.--------·--- Isis Pharmaceuticals/Ibis Laboratory -1891· Rutherford, Carls~ad CA -Control Area 2/Labs: Hazardo.us Materials Inventory Item CM#·,.:,._._.····stat~· 'Cone%:·,.;aterlal·\/-:-f,,'._, :, -··:. :-.-·,.·. ' .. · . . . . ·\·:· . --• i-" .. · ~ . . ~; ·. . ... : . ... . . . :'l ... ·-=-•' • • ' .... ·: • • ' ', .'': ..... .-: ·. "f./:i:fazardClass··. :,_Storage/u!lits· Cabs i.EV ... _,.,. . . .. . . . -: . . ... Location 252 1119-94-4 s 100 Dodecyltrimethylammonium Bromide [latnyltrimethyiammonium Bromide) [RTECS# IR 0.220? Lbs Control Area 2 -New Haz Mat locations 803195000) [HR:.H2] 253 60-00-4* l </=50 EDTA [Ethylenediaminetetraacetic Acid) (EDTA Free Acid) (ACS Reagent) [Aqueous IR 0.3963 Gins Control Area 2 -New Haz Mat locations Solution/May Contain Sodium Hydroxide/1310-73-2 -FP None] [HR: H1] 254 60-00-4 s 100 EDTA (Ethylenediamlnetetraacetic Acid] [EDTA Free Acid) (ACS Reagent] [MP 250o]' IR 2.2100 lbs Control Area 2 -New Haz Mat locations (RTECS#AH4025000) [HR: H1J ·-----·--- 255 51-43-4 s 100 Epinephrine ((R)·(·)·J [Deoxyeplnephrlne) (Adrenaline) [Vasotoniri] [(RH-)-3,4-HT,.OHH 0.0220 lbs y Control Area 2 -New Haz Mat locations dihydroxy-alpha-(rnethylaminomelhyl)benzyl alcohol] [LD50-S: 62 mg/kg] [MP 215oC] [HR: H4] ---·----- 256 114-07-8 s 100 Erythromycln [MP 133oC] [LD50-0: 4600 mg/kg) [RTECS# KF4375000) [HR: H2) · IR,OHH 0.0110 lbs Control Area 2 -New Haz Mat locations -----------~--- 257 107-22-2 l 40 Ethane!lione (1,2-) [Glyoxal] [Aqueous Solution) [FP None] [RTECS# MD2700000] IR 0.2202 Gins Control Area 2 -New Haz Mat locations [HR: H2] 258 64-17-5 l >/=70 Ethanol (Ethyl AlcohoQ (Reagent Alcohol) [Molasses Alcohol) (Aromatic Elixir) (ETOH) FL 1 B, IR, OHH 15.0000 Gins y FLV Control Area 2 -New Haz Mat Locations (Polyamkle Rinse] (FP55.6oF; BP 78.32oC] [I.EL: 3.3%; UEL: 19%) (SG 0.789; VD 1.594] [LD50-0 7060 mg/kg; LC50 >10,000 ppm][RTECS# KQ6300000] [HR: H3 F3] -~-·-----·- 259 141-43-5 ,. L 100 Ethanolamlne'[2-Amlnoethanol] [Monoaminoethanol) [Monoethanofamlne] (BP 170-Cl3B, CR, OHH, 0.1321 Gins Control Area 2 -New Haz Mat L9C8tions 340oF; FP 185-200oF] [LEL: 3%: UE~: 23.5%) [lD50-0: 2,140 mg/kg;l050-S: TX 1,000 mg/kg] [ph: 11.5-12.2] [RTECS# KJ5n50!)0] [HR: H3 F1 COR] • 260 110-80-5 L 100 Ethoxyethanol (2-) [Cellosoive] [Ethylene Glycol Ethyl Ether] [Silver Extender) [Oxitol] CL2, IR;OHH, P65 1.3209 Gins CLY Control Area 2 -New Haz Mat locations (EB Glycol Ether) [FP 108oF] [HR: H3 F2] 261 17450-56-5 l 100 Ethyl Benzorlacrylate [BP 1840; FP >230oF] [HR:'H1 F1] CL3B,IR 0.0066 Gins Control Area 2 -New Haz Mat Locations 262 120-43-4 L 100 Ethyl 1-Piperazinecarboxylate [BP 273oC; FP >230oF] [RTECS# TL 1378000] [HR: CL3B,IR 0.2202 Gins Control Area 2 -New Haz Mat Locations H1 F1] 263 J41-78-6 L 100 Ethyl Acetate [BP 171oF; FP 55oF; AIT: 800oF] [LEl: 2.2%; UEL: 11.5%][SG 0.902; FL 18, IR, OHH 0.0613 Gins y FLV Control Area 2 -New·Haz Mat locations VD 3.049) [LD50-0 5620 mg/kg] [RTECS# AH5425000) [HR: H2 F3] 264 105-36-2 L 100 Ethyl Bromoacetate [BP 159oC; FP 11 BoF] [RTECS# AF600000) [HR: H3 F2 CORI · CL2, CR 0.1321 Gins CLV Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount In use and storage, unless otherwise-noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire bulldtng, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L103, Magnet Room/L109, Mass Spectrometry Lab/L110, Robotics Lab/L10:I, Refrigerator/L103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Bulldlng Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPAN<:;Y CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 18 '\ - --W L-~-~~-~· ~;~~~-----'--c-~W.,,,i -] -~~ --~-: ___ ···- Isis Pharmaceutica.ls/lbis '-~boratory -1891 Rutherford, Carlsbad CA -Control.Area 2/Labs: Hazardous Mctterials Inventory. lte11f'cASi#·. ~~>.,.,\Sblte~: Conc,Y.-'·'Miteiiai .. :, ; : . ·;. \<·.>:?'" · .. ,.: -,-.. '~-.-:::-.. ·,Hazard.Clas•.:,•,: Storage Units Cabs LEV Locat)on ,• •• • •••• ·-• • l , • ·-•J • ; ·~ • • .·.:. • • •2 . . ·' • • . • • • . ' .• ' . 265 60-29-7 L 100 Ethyl Ether [Ether] [Diethyl Ether] [FP -40-45oF;,BP 94.6oF.] [LEL: 1.9; UEL: 36] FL 1A, JR, RMP-T2 0.0713 Gins Y 'FLV Control Area 2-New Haz Mat Locations (MW: 74.122} [SG: 0.713]'[VD: 2.565; VP: 8:547 psla] [tD50-01215 mg/kg; LC50 103,222] [RTECS# L 15TT5000] [HR: H2 F4] 266 924-44-7 L 100 Ethyl Glyocaie Solution (Ethyl Oxoacetate}PnT~luen.!!/108-88-3] [BP 110oC; FP FL1B, JR, 0HH, 0.0264 Gins · Y FLV Control Area 2-New Haz Mat Locations 44.6oF) [LEL: 1.1; UEP,11 [VD 3.1; SG 1; VP 28.53) [LD50-0: 5,000 mg/kg][FV P65 per Gin: 125P) (RTECS# XS5250000] [HR: H2 F3) ----~---~------~-------------------------------"-------------' ------ 267 2949-22-6 .. L 100 Ethyllsocyariatoacetate [BP 67oC;.FP 163oF][Aklrich 238627] [LD50-01130 CL3A, JR, SN, WR1 0.0110 Gins . CLV Control Area 2-New Haz Mat Locations mg/kg} [RTECS# Al4450000) [HR: H3 F2 R1} 268 107-21-1 L 100 Ethylene Glycol (1,2-Elhanedioq [EGJ [MACuDlzer 9221-S] [MacOermkf 19227) CL3B, JR, OHH 10.0000 Gins Control Area 2-New Haz Mat Locations [Dowtherm 4000] [Red Devil Onetime Spackllng] [FP 232oF] (HR: H2 F1] . 269 110-71-4 L 100 Ethylene Glycol Dimethyl Ether [1,2-Dimelhoxyethanel[Monog)yme}(EGDME} [MP -FL 1 B, IR, OHH 1 :8492 Gins Y FLV Control Area 2 -New Haz Mat Locations 58oC; FP 32oF; BP 85oCJ [SG 0.867; VD 3.1-[LE;L 1.6; UEL 10.4) [RTECS# KI1451000f [HR: H2 F3J 270 107-15-3 L 100 Ethyleiledlamlne [1,2-Ethanedlamlne][1,~-Diaminoethane][LD50-0ral: 500 mg/kg] CR, FL1C, TX, 1.0831 'Gins Y FLV Control Area 2 -New HatMat Locations [BP 118o;C FP 93oF] [SG 0.899; VD 2.07] [LEL 2.7; UEL 16J[RTECS# KH8575000) RMP-T1, RMP-T3 [l:IR: H3 F3 COR] 271 6381-92-6 S 100 Ethylenedlamlnetetraacetic Acid Disodium Salt Hydrate IR, 0HH 0.3523 Lbs Control Area 2 -New Haz Mat Locations [{Ethylenedinltrilo)TetraaceticAcid} [DIS9dium EDTA) [DIS!)dium 'Ethylamlnedlaininetetraacetic Acid Disodium Salt Hydrate) [(Ethylenedinltrilo)TetraaceticAci~ Disodlum Salt) [Disodium EDTA) [Hij: H2) 272 140-89-6 S 100 l;thylxanthlc Acid Potassium Salt (0-)[Carbonodithiolc Acid a-Ethyl Ester Potassium JR 0.2202 Lbs Control Area 2-New Haz Mat Locations Salt] [Potassium Xanthogenate] [MP 2100) [RTECS# FG1575000} [HR: H1] 273 26873-85:.S S 100 Ficoli 400 [Nonionic Synthetic Polymer of Sucrose) [Fluka 46328, etaij [HR: OJ NH 1.1013 Lbs Control Area 2 -New Haz Mat Locations 274 28920-43-6 S 100 Fluorenylmethyl Chloroformate (9-) [9-Fluorenylmethoxycarbonyl Chloride][FMOC-CR 0.0550 Lbs Control Area 2 -New Haz Mat Locations CL) [MP 62oC) [RTES# LQ6250000} [HR: H3 COR] 275 28290-43-6 S 100 Fluorenylmethyl Chloroformate (9-) [FMOG-Chlorlde) [MP 62oCJ [RTECS# CR, OHH 0.0661 Lbs Control Area 2-New Haz Mat Locations LQ6250000) [HR: li3 CORJ . 276 367-31-1 S 100 Fluoro-1,2-Phenylenediamlne (4-)(MP 91oCJ [Fluka 47335} [HR: H2] JR 0.0550 Lbs Control Area 2-New Haz M.at Locations 277 7304-32-7 S 100 Fluoro-5-NitrobenzoicAcid (4-) [MP 123oC) [Aldrich 362654] [HR: H2) IR 0.0110 Lbs Control Area 2-New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount== Maxlmumftotal amount In use and storage, unless otherwise noted. Not all materials are In use'at the same time, with <10'Yo In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet RoomfL 109, Mass Spectrometry LabfL 110, Robotics LabfL 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip LabsfL120, Glasswash Lab/L113, Open L:ab/L107 Combustible Dusts: No use, manufacture or,generatlon of dusts In such a manner that concentrations and conditions create a-fire or explosion potential. Pyroph'orlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 19 - --... t-,,,,,.,. 1§:'"·-f.!'=~ .... ,,-·· --: ~i@1~ '~ ~~---= _;,; .... :,bl _,,_,; .... -; -:_~l .. , w -) --;-~--·-------- Isis Pharmaceutical~/lbis Laboratory -18~1 Rutherford, Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory Hem·}~~#·".::.·: ~h,lt~\t.t>h~¾'_;"M_~ttida1/;_ ·_.,_{/t ... '.:·:_--.·-;_.-:-· .. ,' _::: : : .. Hazard Class · ,.,-Storag~ ·;Units .. . ,• ..... ' Cabs. LEV LocatlolJ 278 405-50-5 s 100 FluorophenylaceticAcid (4-) [MP83oCJ{AJdrich F13304) [HR: H2] IR 0.0550 Lbs Control Area 2 -New Haz Mat Locations 279 35661-39-3 s 100 FMOC-L-Alanine (N-) [Sigma F8632) [HR: H1) IR 0.0044 lbs Control Area 2 -New Haz Mat Locations ___ .., __ 280 35661-60-0 s 100 FMOC-L-Leucin(! [N-(9-Fluorenylmethoxycatbonyl)-L-leucine] [MP 156oC] [Aldrich IR 2.2026 Lbs Control Area 2 -New Haz Mat Locations 408611] [HR: H1] 281 6035-45-6 s 100 Folinlc Acid Calcium Salt Hydrate [Leucovorin Calcium] [N-Formyl-5;6,7,8-IR,SN 0.0220 Lbs Control Area 2 -New Haz Mat Locations Tetrahydropteroyl-L-Glutamlc Acid) [HR: H2] >/=BO '' 282 50-00-0 L Foonaldehyde [Formalin) [Ward.Safe Preservative] [BP 100oC; FP 130oF] [LEl: 7%; CA, CL2, IR, OHH, 2.3000 Gins CLV Control Area 2 -New Haz Mat Locations UEL: 60%] [LD50-0: 500 mg/kg; LD50-S: 270 mg/kgf[RTECS# LP8925000] [HR: H3 TX, PSM, P65, F2] RMP-T1, RMP-T3 283 75-12-7 L 100 Formamide [React 2, 3, 6, 7 GenePrint loading solutions] [MP 1-3oC; BP 210oC; FP CL3B, IR, OHH 0.5284 Gins Control Area 2 -New Haz Mat Locations 310oF] [RTECS# LQ0525000] [HR: H2 F1] 284 4347-31-3 s 100 Formylthiopene-3-BoronlcAcid [MP 167oCJ [Aldrich 499900] [HR: H1] IR 0.0110 Lbs Control Area 2 -New Haz Mat Locations 285 110-00-9 L 100 Furan [Furfuran] [Oxacycfopentadlene] [Tetrole] [BP 89.SoF; FP -32oF] [LEL: 2.31 CA, FL 1A, HT, 0.0264 Gins y FLV Control Area 2 -New Haz Mat Locations UEL: 14.3] [SG: 0.936; VD: 2.3] [MW: 68.08] [LC50 3398 ppm] [Narcotic] [RTECS# OHH, UR1, PSM, LT8524000] [HR: H4 F4 R1] . P65, RMP-T1, RMP-T3. 286 527-69-5 . L ,100 Furoyl Chloride (2-) [BP 173oC; FP 185oF] [Aldrich 149861] [HR: H3 F2 R1 COR] CL3A, CR, WR1 0.0550 Gins CLV Control Area 2-.New Haz Mat Locations 287 2103-64-2 . s 100 Gallein [Mordant Vlolet 25] [Cl 45445] [HR: H1J IR 0.0110 tbs Control Area 2 -New Haz Mat Locations 288 526-95-4 L 50 Gluconlc Acid (D-) (50% Aqueous Solution] [FP None] [Aldrich G1139] [HR: H3 COR] CR, OHH 0.0550 Gins Control Area 2 -NewHaz Mat Locations 289 66~-2 s 100 ·Glucosamine Hydrochloride (D-) [2-Amlno-2-deoxy-D-glucose] [Chitosamine IR 0.05~0 Lbs Control Area 2 -New H11z Mat Locations hydrochloride] [MP 190oC) [LD50-0 15 gm/kg) [RTECS# LZ6665000] [Aldrich G2206][HR: H1) 290 50-99-7 s 100 Glucose (Beta-D(+)-) [Dextrose] [Cerelose] [LD50-0: 2800 mg/kg] [MP 146oC] OHH 3.0000 Lbs Control Area 2 -New Haz Mat Locatlons [RTECS# 1.26600000] [HR: H1] 291 19473-49-5 s 100 GlutamicAcld Monopotassium Salt (L-) [MP >100oCJ [HR: H1] IR 0.2202 Lbs Control Area 2 -New Haz Mat Locations 292 56-85-9· L 10 Glutamine (L-) [L-2-Aminoglutaramic acid) [L-Glutamlc acid 5-amlde] [MP 185oC] NH 1.3210 Gins Control Area 2 -New Haz Mat Locations [Flsche(s Medium] [Hybri-Max] [FP None] [RTECS# MA2275100] [HR: OJ LEV: Local or general/area exhaust ventilation required for Class I, II arid Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maxlmu'!'/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire bulldlng, excluding Chemical Waste Storage/Rooms L 114 & L 117. · Existing Haz Mat Locations: Cold Room/L103, Magnet Room/L109, Mass Spectrometry Lab/L110, Robotics Lab/L101, Refrigerator/L103 New Haz Mat Locations: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. PYfophorlcs: Storage and use-closed system conditions only. Bullding Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS· ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 • PAGE 20 - -- .• ~ ,. --,----r.;-,~ ~ <:( ~ ,cl£ ~ .. :.-.~--,·-·-·· -,--. ,; --j'·;'\ ---, ---··· .... ----:u....._"",.~ ..... ___ _. ____ .:; _:._,,; ~ -· -: . -----. Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Carlsbad CA-Control Area,2/Labs:. Hazardous Materials Inventory · Item C~# : State.s.Conc% ·,Material·:·· --· .· _. . ... , . . _,. ,··. . . tfazard Cl_as!I · -:. Storage :.U~lts Cabs LEV. Locatioh 293 56-85-9 s 294 56-81-5 L 295 1668-10-6 s 296 56-40-6 s 297 623-33-6 s 298 27532-9&:3 s ?,19 593-84-0 s 300 50-01-1* L 301 50-0M s 302 5418-95-1 s 303 7665-99-8 s 304 11138-66-2 s 305 7440-59-7 CG 306 7440-59-7 CG 307 7365-45-9 s ·100 Glulamine (L-) [L-2-Aminoglutaramic acid) [I.A31ulaniic acid 5-amlde] [MP 185oC] '[RTECS# MA2275100) [HR: OJ . 100 Glycelin [Glyceroij [1,2,3-Propanetliol) [Laemmuli Sample Buffer][FP a200F: BP 182oC) [LD50-0 12,600 mg/kg) [RTECS# MA8050000] [HR: H1 ·F1) 100 Glyclnamlde Hydrochloride [MP 204oC] [Aldrich G6104) [HR: H1] NH CL3B, IR, OHH IR 100 Glycine [Amlnoacetic Acid) [L-Glycine] [MP 240oC] [LD50-0 7930 mg/kg] [RTECS# IR MB7600000) [HR: H1] 100 Glycine Ethyl Ester Hydrochloride [Glycine Ethyl Ether] [MP 145oC) [RTECS# MC0525000) [HR: H2) 100 Glycine tert-Butyl Ester Hydrochlolide [MP 141oC] [Aldrich 347957] [HR: H1] .IR IR 100 Guanldine lsothiocyanate (Guanidine Thiocyanate] [MP 120oC] [RTCS# XL 12250091 IR [HR:H2) </=50 Guanldine Monohydrochloride [Guanidlne Hydrochloride) [Aqueous Solution -FP None) [pH 5.33] [LD50-0: 950 mg/kg) [RTECS# MF4300000J [HR: H2) IR 10Q. Guanldine Monohydrochloride [Guanidlne Hydrochloride) [MP 185oC] [LD50-0 475 IR, TX mg/kg) [RTECS# MF4300000J [HR: H3J 100 Guanldinol?enzlmklazole (2-) [MP 242oCJ [HR: H1) IR 100 ·Guanosine-3':5'-Cyclic Monophosphate Free Acid [CGMP] [HR: H2J IR,OHH 100 Gum Xanthap [Xanthan Gum) [Kelzan) [HR: OJ NH 100 Helium [He) [aw: 4.00) [96.71 cfnb] [HR: OJ NH 100 Helium [He] [aw: 4.00] [96.71 cf/lb] [HR: OJ NH 100 HEPES (4-(2-Hydroxyethyl)-1.Plperazineethane SulfonicAcldJ [N-2-IR Hydroxyelhylpiperazlne-N'-2-Elhanesulfonic Acid! [MP 2340) [RTECS# TL6809000J [HR:H1J 0.0550 Lbs 1.0832 Gins 0.0330 Lbs 0.2202 Lbs 0,2202 Lbs 0.0110 Lbs 1:1013 Lbs 0.1321 Gins 4.6402 Lbs 0.0110 Lbs 0.0132 lbs 0.2202 Lbs 400.0000 Cf 300.0000 Cf 1.1013 Lbs Control Area 2 -New Haz Mat Locations Control Area·2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 " New Haz Mat Locations Control Area·2 -New Haz Mat Locations Control Area 2 -New Haz·Mat Locations Gonlfol Area 2 -New Haz Mat Locations· Control Area 2-New Haz Mat Locations· Control Area 2 -Existing H~z Mat Locations Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventllation required for Class I, II and Ill-A Liquid~ use-open conditions. CLV-Combustlble Liquid Vapor. FLV-Flammable Liquid Vapor. Storage Amount= Maxlmum/totlll amount In use and storage, unless otherwise noted. Not all materh1ls are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/RQoms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L101, Refrlgerator/L103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building is protected throughout by an automatic fire sprinkler system. · HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 21 - ---r-rt!.:' . t,~. ~-~--~--1~r ·--;.:_ ... :_JW~~-: _,J --~1 --._.;' _, -:- Isis Pharmaceuticals/Ibis Laboratory-11J91 Rutherford, Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory ~-----.:--- ·1t,m.:CAS#.<< .$late c~~t.::'.= .... t~rlal·:,:.'.:·;_:'~?~:: ._ ... .'., ;. .. . ... . -·:-, . Hazard Class-Storage-Units Cabs LEV Location . • • •. !_., •-'· • . • •• • • • --~--·-:·.~---··· --.~--~:·. •• • • ' • '~ •• -~ • ••• :. •• • • ' 308 7365-45-9• L · </=50 HEPES [4-(2-Hydroxyelhyl)-1-Piperazineethane Sulfonlc Acid] [N-2-IR 1.0567 Gins Control Area 2 -New Haz Mat Locations Hydroxyethylpiperazine-N'-2-Ethanesulfonlc Acid] [MP 2340] [RTECS# TL6809000] 309 752n-39-3 s 310 1121-92-2 L 311 1483-67-6 L 312 67-72-1 s 313 50-02-2 s 314 920-66-1 L 315 sao:31-9 L 316 110-54-3 . L 317 73513-42-5 ;• L 318 51-45-6 s 319 56-92-8 s 320 5427-26-9 s 321 302-01-2 L ~~ . 100 HEPES Sodium Salt [4-2-Hydroxyethyl-1-Piperazineethariesulfonlc Acid, Sodium Salt] [RTECS# 233B89][HR: H1J IR 100 Heptamelhylenelmine [Azacyclooctane) [Octahydroazocine) [BP 51oC/15mm; FP FL 1C, IR 85oF) [SG 0.89; VD 3.9] RTECS# CN825000) [HR: H2 F3) 100 Heptynolc Acid (H [BP 202oC;·FP 220oF] [HR: H2 F1 COR] 100 Hexachloroelhane [MP 190oC) [RTECS# Kl4015000] [HR: H2] 100 Hexadrol [Dexamethasone] [Dexamethaonsodium Phosphate] [Decasone) [MP 262oC] (Aldrich 861871) [RTECS# TU3980000] [HR: H2) Cl3B,CR CA, JR, OHH, P65 IR,OHH 100 Hexaffuoroisopropanol (1, 1, 1,3,3,3-) [1,1",1,3,3,3-Hexaftuoro-2-Propanol] [HFIP) [HR: CR H3COR] 100 Hexamelhylphosphoramlde [Hexamethylphosphorlc·Triamlde] [HEMPA] [HMPA] CA, Ct3B, IR, [HPT} [BP 2~0o; FP 222oF) [RTECS#TD0875000) [LD50-0: 2650 mg/kg; LD50-S: OHH, P65 2600 mg/kg] [HR: H2 F1] 100 Hexane(n-) [BP 156oF; FP-10oFJ[LEL: 1.1; UEL: 7.5;SG 0.655; VD2.983; tvfN FL1B, IR 86.2] [LD50-0 28710 mg/kg) [RTECS# MN9275000] [HR: H2 F3) 100 Hexa11es [HexanesAnhydrous)[E!P 68oC; FP-9of){VD 3; SG 0.672) [LEL 1.1; UEL FL1B, IR,_OHH 7.5)[Aldrich 439185 et al] [HR: H2 F3] ~ 100 Histamine [Hlstoclear) [MP ~3oC; FP None) [LD50-0 220 mg/kg] [RTECS# MS1050000) [HR:·H3) IR,OHH,TX 100 Histamine Dlhydrochlori~e [2-(4-lmidazolyl)elhylamlne dihydrochloride] [MP 249oC] IR, OHH, SN (RTECS# MS1575000) [Hft H2] 100 Hydantolnacetic Acid (5-) [MP 214oC) (Aldrich 850624] [HR: H1) JR 100 Hydrazine [Diamide] [Diamine) [MP 1.4oC; BP 113oC; FP 126oF] [LD50-0: 60 CA, CL2, CR, HT, mg/kg; LD50-S: 91 mg/kg; LC50: 1,140 ppm] [RTECS# MV8050000) [HR: H4 F2 R2 OHH, UR2, P65, CORI RMP-T1, RMP-T3 0.2202 Lbs Control-Area 2-New Haz Mat Locations 0.2202 . Gins Y FLV Control Area 2 -New Haz Mat Locations 0.0022 Gins Control-Area 2 -New Haz Mat Locations 0.2202 Lbs Control Area 2 -New Haz Mat Locations 0.0002 Lbs Control Area-2 -New Haz Mat Locations 0.0550 •Gins Control Area 2 -New Haz Mat Locations. 0.1541 Gins Control Area 2 , New Haz Mat Locations 2.2455 Gins Y FLV Conirol Area 2 -New Haz Mat Locations 10.3029 Gins Y FLV Control Area 2 -New Haz Mat Locations 0.0110 Lbs Control Area 2 -New Haz Mat Locations 0.2202 Lbs Control Area 2 -New Haz Mat Locations 0.0330 Lbs Control Area 2 • New Haz Mat Locations 0.0269 Gins Y CLV · Control Area 2 -New Haz Mat Locations -· ·-·--------- LEV:: Local or generalfarea exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L103, Magnet Room/L109, Mass Spectrometry Lab/L110, Robotics Lab/L101, Refrigerator/L103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS· ERIKSEN-RATTAN ASSOCIATES INC.· 11/13/2001 • PAGE 22 - ··:·:·:_,. -- . ~ ,-.·-r:::-l'i.7-'f.·-· ~$~:-· ·r-·'0°"-·,, .. -,"-·: IIIIL·,. --., -"' _, ----. ---~ t._ ~ ~-f;f~: ' ~~--.. -! ,_,_: _.: .~ .... ~ s . . ~ :~_. .---....... Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Carlsbad CA -Control Area 2/Labs: Hazardous Materials Inventory lte"1_}CAl~f_.:,.(,?.'._.:_.~ia~_:-_CQn~% ... ;~~t~rl~,.·<-\,_ }: · .. /_'·_.·.·, ~'.:'°-.. /:,.::-,·· -, / . .-. · ... '. _.: ·_:··· .. · ·_·· . _H~r~_~jass· Stora~e U~its Cabs. _i.EV L~tl_on 322 10217-52-4 L . 85 Hydrazine Hydrate [FP 204oF] [LD50-O: 29 mg/kg] [RTECS# MV8050000] [HR: H3 CA, CL3B, CR, ·0.05.51 Gins Control Area 2 -New Haz Mat locations F1 R1 CQRJ . OHH; TX, UR1 ~------- 323 10035-10-6 L >/=50 Hydrobromic Acid [Hydrogen Bromide] [HBr] [FP None] [LC50: 2,858 ppm] [RTECS# · CR, PSM 0.2114 Gins Control Area·2 -·New Haz Mat Locations MW3850000] [HR: H3 COR] 324 7647-01-0 L >/=30 Hydrogen Chloride [Hydrochloric Acid) [Muriatic Acid) [Aqueous Solution] [HCI] [Acid) CR, PSM, RMP-T1 15.o6i4 Gins Control Area 2 -New Haz Mat Locations [pH: <1) [LD50-0: 900 mg/kg; LC50: 3,124 ppm) [RTECS# MW4025000) [HR: H3 COR] 325· 32001-55-1 L 100 Hydrogen Fluoride-Pyridine [Pyridinium Poly(Hydrogen Fluoride)l.[FP None) (Aldrich CR, WR1 184225] [HR: H3 COR R1) 0.0220 Gins Control Area 2 -N!!W Haz Mat Locations 326 21598-06-1 s 100 Hydroxy-2-lndolecarboxyticAcid (5-) [MP 249oC) [Aldrich 143510) [HR: H1] IR 0.0002 lbs Control Area 2 -New Haz Mat Locations 327 118-71-8 s 100 Hydroxy-2-Methyl-4-Pyrone (3-) [Maltol] [MP 1610) [RTECS# UQ1050000] [HR: H2) IR 0.2202 lbs Control Area 2 -New H~ Mat Locations 328 96-97-9 s 100 Hydroxy-5-Nitrobenzoic Acid (2-) [5-NitrosalicylicAcidJ [HR: H2J IR 0.0550 Lbs Control Area 2 -New Haz Mat Locations 329 100-83-4 s 100 Hydroxybenzaldehyde (3-)MP 103oC; BP 191oC/50mm] [RTECS# CU6450000J IR 0.4405 Lbs Control Area 2 -New Haz Mat Locations [HR:H2] 330 1137-42-4 s 1Q0 Hydroxybenzophenone (4-) [MP 132oCJ [LO50-0 12,086 mg/kg] [RTECS# IR 0.0550 Lbs Control Area 2 -New Haz Mat Locations PC4959775J (Aldrich H20202J [HR: H1J 331 14191-95-8 s 100 Hydroxyben~ Cyanide (4-) (4-Hydroxyphenylacetoni!rile] [RTECS# AM0530000J IR 0'.0110 Lbs Control Area 2 -New Haz Mat Locatiqns [HR:H2] 332 502-85-2 s 100 Hydroxybutyric Acid Sodium Salt (4-) [Sodium Oxybate] [HR: !-12) IR 0.2202 Lbs Control Area 2 • New Haz Mat Loi:ations 333 86-77-1 s 100 Hydroxydibenzofuran (2-) [MP 133oCJ [HR: H1) IR 0.0550 Lbs Control Area 2 -New Haz Mat Locations 334 16052-06-5 s 100 Hydroxyelhyl,1-PiperazinepropanesulfonicAcid (4-2-) [EPPS) [RTECS# IR 0.2202 Lbs Control Area 2 -New Haz Mat Location~ TM2649130) [HR: H2] 335 7803-49-8* L 50 Hydroxyl;,imlne [RTECS# NC2975000) (50% Aqueous Solution] [BP 107oC; FP CR, OHH;UR2, 0.0661 Gins Control Area 2 -New Haz Mat Locations None] [RTECS# NC2975000J [HR: H3 R3 COR] 'PSM 336 2950-43-8 s 100 Hydroxylamlne-O-SulfonlcAcid [MP 210oC) [Aldrich 213136] [HR: H3 CORI CR,OHH 0.0550 Lbs Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount = Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion _potential. Pyropht>rics: Storage and use-closed system conditions only. Building is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 23 - --. --{--%11:-f'.r.'· !f@'i.iw:'.'JE'•.'J..'-·''··. --........ '--·,, --'!) ' ~ ~ '-3/>·" ~:;f...._:~~~---~......._.~--t .....__., , ... i;s ~ -~: -'.-'.:-.:--,·- Isis .Pharmaceuticals/Ibis Laboratory -1891-Rutherford, Car.lsba~ CA -Control Area 2/Labs: Hazardous Materials Inventory .,tem::PAS#.::::~?-;_:·,.. ~_tate:,:_.~~~<:~,f-:~·atera•-.':.· ··:. i.·>:·::.:.-.\. ::·: .. ,-,. ·: .. \ Hazard Class . ·St9rage Units Cabs LEV Location . , ···"'' .. 337 148•24-3 s 100 Hydroxyquinoline (8-) [Carbostyril) (8-Quinolinol) (MP 72oCJ [RTEGS# VC4200000] GR 0.0550 Lbs Control Area 2 -New Haz Mat Locations [HR:H3COR] ------·•-•• • OH~-~----·---•••- 338 6066-82-6 s 100 Hydroxysucclnimlde (N-) [MP 95oC] (Aldrich 230672} [HR: H2 W1J IR,WR1 0.0550 Lbs Control Area 2 -New Haz MafLocations 339 31282-04-9 s >/=60 Hygromygin B [D-Steptamlne] [Antihelmycin] (Hydromycin BJ [Hygromix} [LD50-0ral: IR,OHH,TX 0.0022 Lbs Control Area·2--New Haz Mat locations 63 mg/kg] [RTECS# WK2130000} [HR: H3) 340 57583-56-9 L </=50 Hypophosphorous Acid [50% Solution in Deuterum Oxlde/7789-20-0] [FP None] CR,OHH 0.0110 Gins Control Area 2 -N~ Haz Mat Locations (Aldrich 176680] (HR: H2 COR} 341 288-32-4 s 100 lmidazole (MP 89oC; BP 256oC] [RTECS# Nl3325000] [HR: H3 CORJ CR 2.4229 Lbs Control Area 2 -New Haz Mat Locations 342 1467-16-9 .. s 100 lmldazole Hydrochloride [MP 158-161oC] [HR: H2) IR 0.0110 Lbs Control Area 2 -New Haz Mat Locations 343 142-73-4 s 100 lminodiacelic Acid [Chelating Resin) [HR: H2J IR 1.1564 Lbs Control Area 2 -New Haz Mat Locations ···----- 344 , 9024-82-2 s 100 Inorganic Pyrophosphatase [Pyrophosphate Phosphohydrolase} (Sigma 12267) [HR: NH 1.1013 Lbs Conlrol·Area 2 : New Haz Mat Locations OJ 345 77282-71-4 s 100 Insulin Chain A [Oxidized-from Bovine Insulin Ammonium Salt} [Sigma 11633] (HR: IR 0.0022 Lbs Control Area 2 -New Haz Mat Locations H1J ------- 346 7553-56-2 s 100 Iodine [Crystaij [Gram Iodine} [LD50-0: 14 g/kg; LC50: >2,000 ppm} [RTECS# CR,OX2 0.4646 Lbs Control Area 2 , New Haz Mat Locations NN1575000] [HR: H3 COR OX] 347 624-75-9 L 100 lodoacetonltriie [BP 182oC; FP 187 of] (Aldrich 16903] [HR: H3 F2 COR] CL3A,CR 0.0220 Gins CLV Control Area 2 -New Haz Mat Locations 348 88-67-5 s 100 lodobenzoicAcid (2-) [MP 162oCJ [RTECS/# DH2975000] [HR: H2] IR 0.1101 Lbs Control Area 2 -New Haz Mat Locations 349 619-58-9 s 100 lodobenzoic Acid (4-) [MP 272oC] [Aldrich 206547] [HR: H2] · IR 0.0110 Lbs Control Area 2 -New,Haz Mat Locations 350 624-76-0 L 100 · lodoethanol (2-) [FP 150oF; BP 85oC] [RTECS# Kt.S3820QOO] [HR: H3 F2] CL3A, IR, OHH 0.0550 Gins CLV Control Area 2 -New Haz Mat Locations 351 74-88-4 L 100 lodomelhane [Methyl Iodide] [tert-Butyl Methyl Ether] [Stabilized with Copper] [MP -CA, IR, OHH, TX, 1.5419 Gins Control Area 2 -New Haz Mat Locations 64oC; BP 41oC; FP None] [LC50: 447 ppm; LD50-0: C150 mg/kg; LC50-S: 800 UR1, PSM, P65 mg/kg] [RTECS# PA9450000] [HR: H3 R1] 352 516-1_2,1 s 100 lodosuccinimide (N-) (MP 202oC] [RTECS# WN2817000] [HR: H2] IR,OHH 0.0330 Lbs Control Area 2 -New Haz Mat Locations 353 122560-63-8 s 100 Ion Exchange Resin [Amberlite IRA-400(CI) [Basic] [HR: H1] iR 1.7621 Lbs Control Area 2 -New Haz Mat Locations -----·-"-----· LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustlble Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount = Maximum/total amount In use and storage, unless otherwise noted, Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L103, Magnet Room/L109, Mass Spectrometry Lab/L110, Robotics Lab/L101, Refrigerator/L103 New Haz Mat Locations: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open 1-ab/L 107 CombustlbJe Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 24 - -.. --c-,[1P_'-'"'-'""'" .. ..,,.,1'J' -.. ·,,-·-,-. -" _,a, ~:...a..f~.Z~ ~~·, .c·-.cr~lllllla,,,._,· _,: ·~~ . ,.Zi -; -·-;__ · .. ----~·- Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Ca.rlsbad CA -Cc;mtrol, Area 2/Labs: Hazardous Materials Inventory Item•: CAS# _:. ::· ::::r~;'-·State' .conco/;·, Material:,·': :;;,'",: ,. .· .. , .. : :-Hazard Class .' Storage; Units Cabs LEV Location . ·"'--------.... ·_·. ' .. •. '. --. . . . . . . ,. .. . , . .-·. . 354 53025-53-9 ,. S 100 Ion Exchange R~ln [Dowex MSC-1 Macroporous·lon-Exchange Resln][Aldrich IR 1.1013 Lbs Control Area2 -New Haz Mat Locations 428787] [HR: H1] --------~------~-----~-------~-----------~-----'---_ .. _____ ,, ___ ,_ ,., _____ ,,_,, _,_,_.,.,,_,,_ 355 7 439-89-6 s 356 7782-63-0 s 357 7705-08-0 s 358 10025-77-1 s 359 10028-22-5 ... s 360 123-51-3 L 361 79-30-1 L 362 641-74-7 s- 363 39546-32-2 s 364 498-94-2 s 365 67-63-0 L 366 67-63-0 L 100 . · 1ron [Powder} [RTECS# NO4565500J [HR: F21 FS 100 lron(II} Sulfate Heptahydrate [Ferrous Sulfate Heptahydrate] [LDLo-0: 1,389 mgkgJ IR, OHH; WR1 [RTECS# N08510000J [HR: H2 R1] 100 lron(III} Chlorid!;! [Ferric Chloride] [MP 304oCJ [LD50-0 450 mg/kg} [RTECS# LJ9100000J [HR: H3 COR] CR,TX 100 lron(III} Chloride Hexahydrate [Ferric Chloride Hexahydrate] [MP 303oJ [LD50-0: 450 CR, TX mg/kg} [DOT Label 8l[RTECS# NO52525000] [HR: H3 COR] 100 lron(III} Sulfate n-Hydrate [Ferric Sulfa!E! Hydrate] [Iron Sesquisulfate Hydrate] [HR: IR, OHH H2] 100 lsoamyl Alcohol (3,Methyl-1-Butanol]Psopentyl Alcohoq [FP 114oF; BP 130oF] [LEL: CL2, IR, SN 1.2; UEL: 9.0] [LD50-01300 nig/kgj [RTECS# EL5425000] [HR: H2 F2] , 100 l~obutyryl Chloride [MP-90o; BP 91oC; FP 34oF)' [SG 1.107; VD 3.687] [HR: F3 H3 CR, Fl.:18; WR2 R2CORWR] 100 lsom~nnide (1,4:3,6-Dianhydro-D-Mannitoij [HR: H2] IR 100-lsonlpecotamlde [Hexahydrolsonlcotinami~e] [4.Piperidinecarboxamide) [MP 145oC]' IR [Aldrich 117907] [HR: H2] , ~00 lsonlpecotic Ack! [Hexahydroisonicotinlc Acjd) [MP >100oC)[RTRECS# NS5150000] IR [HR:H2] >/=70 lsopropanol [lsopropyl Alcohol] (2-Propanol] [Alcohol] [A870-25 Solder Flux) [425 FL 1 B, IR Thinner] [LD50-O: 5,840 mg/kg; L050-S: 13,000 mg/kg] [FP 53oF; BP 82.5oC] [I.EL: 2.5%; UEL: 12%] [SG 2.079; VD 0.785) [LD50-O 5045 mg/kg] [RTECS# NT8050000) [HR: H2 F3J >/=70 lsopropanol [lsopropyl Alcohol} [2-Propanol] [Alcohol] [A870-25 Solder Flux) (425 FL 18, IR- Thlnner) [LD50-O: 5,840 mg/kg; LD50-S: 13,000 mg/kg] [FP 53oF; BP 82.5oCJ [I.EL: 2.5%; UEL: 12%) [SG 2.079; VD 0.785] [LD50-0 5045 mg/kg} [RTECS# NT8050000J [HR: H2 F3] 0.1101 Lbs 0.5507 Lbs 0.2202 Lbs 0.2202 Lbs 0.2202 Lbs 0.264i Gins 0.1101 Gins 0.2202 , Lbs 0.2202 Lbs 2.2650 .Lbs 6.0508 Gins, 0.0528 Gins Control Area 2 -New Haz Mat Locations ______ .,.__, -----··-- Control Area 2 • New Haz Mat Locations Control Area 2 • New Haz Mat Locations Control Area 2 • New Haz Mat Locations Control Area 2 -New Haz Mat Locations. CLV Control Area 2 • New Haz Mat Locations Y FLV Control Area 2 -New Haz Mat Locations Con!fol Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat locations Control Area 2 -New Haz Mat Locations Y FLV ,Control Area 2 -New i-faz Mat Locations FLV Control Area 2 -Existing Haz Mat Locations LEV: Local or ge!'eral/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combµstible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at anytime. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDO!JS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS • ERIKSEN-RATTAN ASSOCIATES INC. • 11/13/2001 • PAGE 25 - ... r··M -~-~-8."'J1] ;<:~.::--~--i-~j -~.J lliil2 -:: .. ! ·-.. ---~ .. --- Isis Pharmaceuticals/Ibis Laboratory-1891 Rutherford, Carlsbad CA-Coritrol Area 2/Labs: · Hazardous.Materials Inventory Hem: CAS# ... --; ·. State· :,cone¾ .'·Matilrlal:' ·. . · ... _· , ... ,. : . ·, .. _:: =;,, •' ,• • • •. • •• ,",,;, • • , >, •: :. , • , • '' ~--I • • • '.;_, ~ • • ·:,, 'Hazard.Cla!SS .. Storage Units ·Cabs LEV 367 1795-48-8 L 100 lsopropyllsocyanate [BP 74oC; FP 27oFl[SG 0.868}!Aldrich 141070] [HR: H2 F3 R1] FL 18, IR, SN, WR1 368 75-31-0 L 100 lsopropyiamlne {2-Aminopropane] [Monoisoroylamlne] [BP 33oC; FP -26oF] (LEL 2; CR, FL 113, TX, UEL 10.4) [SG 0.694i VD 2.04]It050-0: 111 mg/kg] [RTECS# NT8400000] [HR: PSM, RMP-T2 H3F3COR] 0.0055 Gins Y FLV 0.1321 Gins Y FLV Location Control A~a 2 -New J-jaz Mat Loci;itlons Control Area 2 -New Haz MafLocatkins 369 · 109-56-8' L 100 lsopropylamino Ethanol (2-) (2-{lsopropylamino)Elhanol] [lsopropylaminoelhanols] CL3A, IR [BP 172oC; FP 168oF] {LD50-0 1250 mg/kg] {RTECS# KL5080000] {HR: H2·F2] 0.1321 Gins CLV Control Area 2 -New Haz Mat Locations 370 367-93-1 s 371 16051-77-7 s 100 lsopropyl-b-0-Thlogalactopyranoslde [IPT~] {sopropyl beta-0-lhlogalaclQSlde] [MP CA, IR, OHH, 120oC; FP >230oF] [Aldrich 858757] [HR: H2] . 100 lsosorbide 5-NJtrate [lsosofblde 5-Moninitrate] [5-ISMN] [LD50-0: 2010 mg/kg] [HR: IR, OHH H2] 0.0110 Lbs Control Area 2 -New Haz Mat Locations 0.0220. Lbs Control Area 2 -New Ha~ Mat Locations 372 503-74-2 L 100 lsovalericAcld [3-MethylbutyricAcld] [BP 1750; FP 159oF] (L050-0: 2,000 mg/kg; CL3A, CR, TX LD50-S: 56() mg/kg] {RTECS# NY1400000] [HR: H3 F2 CORI. 0.0264 Gins CL V Control Area 2 -New l:iaz Mat Locations 373 25389-94-0 374 9051-29-0 375 19172-47-5 376 16853-85-3 377 16949-15-8· 378 16949-15-8- 379 7550-35-8 380 7447-41:.8 381 4111-54-0· s s s s L s s s L 100 Kanamycin Monosulfaie [LD50-0: >4 gml}(g] [RTECS# NZ3225030] [HR: H1) 100 Lactalbumln Hydrolysate [Alpha-Lactalbumin] [Lyphollized Powder] [HR: H1J OHH IR 100 Lawessons Reagent [2,4-bis(4-Melhoxyphenyl)-1,3-Dilhia-2,4-Dlphosphetane-2,4-IR,.WR1 Disulfide] [HR: H2 R1 WR1] 100 Lithium Al~minum Hydride [Lithium Tetrahydride Aluminate] [MP 125oC] {RTECS# CR, FS, OHH 8D0100000] [Aldridi 333403] [HR: F2 tj3 COR] . </=25 Lithium Borohydride [2,0M Solution in Telrahydrofuran] [BP-1oF; BP >100oF [RTECS# OJ62427000] [HR: H3 F3 R1 WR) 100 Lithium Borohydride [RTECS# QJ6427000] [HR: H3 F2 R2 WR] 100 Lithium Bromide [RTECS# OJ5755000] [HR: H2] 100 Lithium Chloride [Lithium Chlorate) (MP 605oC] [LD50-0 526 mg/kg] (RTECS# OJ5950000) [HR: H2) FL 18, IR, OHH, WR1 FS, IR, OHH, WR2 IR IR,OHH </=25 Lithium Diisopropylamlde [2.0M Solution in Heptane/fetrahydrofuran/Ethylbenzene] CR, FL 1A, OHH, (LOA] (FP 5-10oF] [Aldrich 494585, 361798, 296961, 470849] [HR: H3 F4 W2 COR] WR2 0.1652 Lbs 1.3209 Lbs 0.2753 Lbs 0.0528 Lbs 0.1849 Gins 0.2202 Lbs 0.2202 Lbs 0.2202 Lbs 0.0269 Gins Y FLV y Y FLV Conlrol Area 2 -New Haz Mat Locations Control Area 2 -'New Hiiz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locafi<?ns Control Area 2 -New Haz Mat Locatlpns Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and lll~A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Exlstipg Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotic:$ Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture 9r generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC.· 11/13/2001 -PAGE 26 - . . ·. ;_~:· ---qaac-~·:-~~-.. --a.;;:. ....... , .... ,, ..... __ ,, -:!l ----··---~-#·~. :~~ ~--= _; ,4,.,l ·~ . '. .l., ~--~ •• -~ - Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Carlsbad CA-Control Area 2ilabs: . Hazardous Materials Inventory Item: CAS# ~taJ~ ,: Conc~·_.-_M~terlal ... · · : Hazard Class Storage· Units Cabs LEV Location : 382 4111-54-0 s . 100 Lithium Dilsopropylamlde [LDA] [FP -53.6oF) [Aldrich 246611] [HR: H3 F-3 WR COR] CR, OHH, PY, WR2 0.0022 Lbs y Control Area 2·-New Haz Mat Locations. 383 1310-66-3 s 100 Lithium Hydroxide Monohydrate [pH 12] [I.D50-0: 210 mg/kg; LC50: 960 mglm314H] CR, OHH, TX, WR1 2:2026 Lbs Control Area 2 -New Haz'Mat Locations- [RTECS# OJ6~7070) [Aldrich 450197] [HR: H3 R1 COR) 384 37340-57-1 ' s 100 Lyticase [Enzyme Prep] (Sigma L4025] [HR: H1] IR 0.0220 Lbs Cohtrol·Area 2 -New Haz Mat Locations 385 16674-78-5 s -100 Magnesium Acetate Tetrahydrate [Acetic Acid Magnesium Salt] [MP 80oC] [RTECS# IR 0.1672 Lbs Control Area 2 -New Haz Mat-Locations A15600000) [HR: H1] 386 56378-72-4 s 100 Magnesium Carbonate [HR: H1) IR 1.1013 Lbs ·control·Area 2-New Haz Mat Locations 387 39409-82-0 s 100 Magnesium Carbonate [Sigma M7179) [HR: H1J. IR 4.4053 Lbs Control Area 2 -New Haz Mat Locations 388 7487-88-9. L </=50 Magnesium Sulfate [Eco Mag] [HR: ti) NH 0.0264 Gins Control Area 2 -New Haz Mat Locations ·--- 389 7487-88-9 .S 100 Magnesium Sulfate [Eco Mag) [RTECS# OM45000000] [HR: OJ NH 25.8885 Lbs Control Area 2 -New Haz Mat Locations 390 10034-99-8 s 100 Magnesium Sulfate Heptahydrate [Epsom Salts] [RTECS# OM4508000) [HR: OJ NH f.1013 lbs Control Area 2 -New Haz Mat Locations 391 123333-61-f s 100 Malachite Green Carbinol Hydroctiloride [LD50-0: 275 mg/kg] [RTECS# IR,OHH,TX 0.0022 Lbs Control Area 2 -New Haz Mat Locations BQ1180000) [HR: H3) 392 2437-29-8 ·-·s 100 Malachite Green Oxalate [Basic Green 4] (MP 164oC] [LD50-0 275 mg/kg] [RTECS# IR, TX 0.0550 Lbs Control Area 2 -New Haz Mat Locations BQ1190000)[HR: H2) 393 108-31-6 s 100 ·Maleic Anhydride [2,5°Furandione] [Toxillc Anhydride] [LD50-0ral: 400 mg/kg) CR, TX,.l,JR1, WR1 2.2100 Lbs ControJ·Area 2 -New Haz-Mat Locations [ARTECS#'ON3675000) [HR: H3 R1 COR WR) 394 10034;95-5 s 100 ¥anganese(II) Sulfate Monohydrate [Manganous Sulfate MonohydrateJ [RTECS# IR,OHH Q.2202 Lbs Control Area 2 -New Haz Mat Locations OP0893500) (HR: H2) 395 69-65-8 s 100 Mannltol (D-) [Acidified Ammonium Molybdate) [MP 167oCJ [RTECS# OP2060000) NH 0.5507 Lbs Control Area 2 -New Haz-Mat Locations (H_R:O) -- 396 37231-28-0 s 100 Melittin (Bee Venom) [Gly-lle-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu0Pro-Ala-IR, SN 0.0022 Lbs Control Area 2 -New Haz Mat Locations Leu-lle-Ser-Trp-lle-Lys-Arg-Lys-Arg-Gln-Gln-NH2) [RTECS# OS3960000) [HR: H2] 397 94133-41-2 L 100 MenlhoxyaceticAcid [(+)-] [BP 1~3oC/10mm; FP >230oF] [Aldrich 448397] [HR: H1 CL3B,IR 0.0110 Gins Control Area 2 -New Haz Mal Locations F1[ LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount = Maximum/t9tal amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <1 O'Yo in use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing. Haz Mat Locations: Cold Room!L 103, Magnet Room/L 109, Mass ·spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs!L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/1312001 -PAGE 27 - ---call~ """'I;;-fciY1.-.. ~ r::1: .,,,._,, __ ··-·· .. , ___ , --·';; .. : ~ !f~ ·:, .. _..:.. ~--~-.-___ .J .:.,,:_;~ ~ -• --.. ........ -Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Carlsbad CA -Control Area 2/Labs: Hazardous Materials lnventQry item." .. C~# : __ : ...... ~tate:·c::.~ii~¾-::·Ml!terlal ·:_<_.:,:::-,-,:-;: -':.;--:' '. ·, ·/.'' .·_-_.)_,:,:. ~·' . . . '• • .. · -. :· .Haza~d Class· ' ... Storage Units. · Catis LEV . -.. .Location • • • :· ! •' • • 398 68°11-1 L 100 MercaptoacetlcAcid [ThioglycolicAcid] [Thioglycolate] [MP-16oC; BP 96oC/5mm; CL3B,CR, TX 0.0264 Gins. Conirol Area 2 -New Haz Mat Locations FP >230oF] [LD50-0: 114.mg/kg; LD50-S: 300 mg/kg] [RTECS# Al5950000) [HR: H3F1 CORI ---------··----- 399 2382-96-9 ... s 100 Mercaptobenzoaxzole (2-) (2-Benzocazolethiol] [HR: H2) IR 0.0220 Lbs Control Area 2 -·New Haz Mat Locations ---·-·· 400 60-24-2 L 100 Mertl!ploethanol (2-) [2-Hydroxyethylmercaptan] [FP 165oF; BP 157oF] [LD50-0ral: CL3A, HT, IR 0.4838 Gins y CLV Control Area·2 -New Haz Mat Locations 244 mg/kg; LOSO-Skin: 150 mg/kg] [RTECS# KL5600000] [HR: H4 F2] ·-· 401 1450-85-7 ·s 100 Mercaptopyrimldine (2·) [2-Pyrimidinethiol) [MP 230oC) [Aldrich 239623) [HR: H2) JR 0.0220 Lbs Control Area 2 -New Haz Mat Locations 402 592-04-1 s 100 Mercury(II) Cyanide [Mercuric Cyanide) [LD50-0 26 mg/kg] [RTECS# OW1515000] CR, HT, OHH, SN, 0.2202 Lbs y Control Area 2 -New Haz Mat Locations [HR:H3] P65 403 773-64-8 s 100 . Mesltylenesulfonyl Chloride.(2·) [2,4,6-Trimethylbenzenesulfonyl Chloride] [HR: H3 CR,WR1 0.1211 Lbs Control Area 2 -New Haz Mat Locations R1COR] --·----- 404 74257-00-4 s 100 Mesltylenesulfonyl-3-Nitro-1,2,4-Triazole (1-2-) [(2,4,6-Trirnethylph•myl)(3-Nitro-1,2,4-JR 0.0044 Lbs Control Area 2 -New Haz Mat Locations Triazol-1-y)Sulfone] [MSNTI [HR: H2J 405 124-63-0 L 100 Methanesulfonyl Chloride [BP 60o'21mm; FP >230oF] [LDS0-0 50 mg/kg) [RTECS# CL3B, CR, HT, 0.0264 Gins y Control Area 2-New:H!!Z Mat Locations PB2790000] [HR: H3 F1 R2 COR WR] OHH,WR2 406 2491-18-1 s 100 Methionine.Methyl Ester Hydrochloride (L-) [HR: H2] . JR 0.0110 . Lbs Control Area 2· -New Haz Mat Locations -401 98-68-0 s 100 Methoxybenzenesulfonyl Chloride (4-) [MP 40oC; FP 173oC/14mm; FP >230oF] CR 0.1101 Lbs Control Area 2 -New Haz Mat Locations [Aldrich M10204] [HR: H3 CORJ 408 6971-51-3 L 100 Methoxybenzyl Alcohol (3·) [m-Anisyl Alcohol] [BP 250o; FP >230oF] [HR: H2 F1] CL3B,IR 0.0881 Gins · Control Area 2 -New Haz Mat Locations 409 824-98-6 L 100 Methoxybenzyl Chloride (3-) [3-{Chloromethyl)Anlsole] [MP -1o; BP 1170; FP 229oF] CL3B, CR 0.0550 Gins Control Area 2 -New Haz Mat Locations [HR: H3 F1 COR) 410 824-94-2 L 100 Methoxybenzyl Chloride (4-) {4-(Chloromethol)Anlsole] [BP 124oC/12mm; FP 215oF] CL3B, CR 0.0550 Gins Control Area 2 -New Haz Mat Locations {Aldrich 208384) [HR: H3 F1 CORI 411 56651-60-6 L 100 Methoxybenzyl Isocyanate (4-) [BP 60oC/0.6mm; FP >230oF; SG 1.143] [HR: H2 F1 CL3B, IR, SN, WR1 0.0110 Gins Control Area 2 -New Haz Mat Locations R1] 412 2393-23-9 L 100 Methoxybenzylamlne (4-) [BP 236oC; FP >230oF] [HR: H1 F1] CL3B,IR 0.0044 Gins Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vapor. FLV-Flammable Liquid Vapor. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10o/, In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/R~oms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN· ASSOCIATES INC. -11/13/2001 -PAGE 28 - ·.:. -... r r··-11"'-"' .. ~'.·· f~ .. ,,_.,_,_. ,-····--· .... ,l\ -·-· -·-----i •• l_. ....... ~-;,_,.:::. ~~!--.... '-"'-l-·-)l.:.,1iel ,.,.._:_i _ ·..:._; ..... ff --.;; •• • ---,.. .... ,' , Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, C~rlsbad CA -Control Area 2/Labs: Hazardous Materials Inventory .iten('CASt·\ <·-\-$tati.-:'.'c~·i\c% 'Matiriai::-:·;,:\,,\':" ;'·,:.::::: > :;. ', : .' .-:· ...... H~ard:Ciass ' .. 'Storage Units Cabs LEV .Location -.......... •••• __ -~ :-.:·_.· -•• , • .... ! .... ·-: • .... _.-'-. • •• 413 593-56,6 S 100 Methoxylamine Hydrochloride [O-Methylhydroxylaminel[MP 148oCl[Aldrich 226904] CR, OHH t1563 Lbs Control Area ·2-New Haz Mat Locations [HR: H3 COR], 414 5416-93-3 L 100 Methoxyphenyl-lsocyanate (4-) [BP 106oC/16rrim; FP 209oF] [Aldrich 238600] [HR: Ct~B, CR, SN, 0.0110 Gins Control Area 2 -New Haz·~at Locations . H3F1 CORJ WR1 415 611-13-2 L 100 Methyl 2°Furoate [BP 181oCi FP 164oF) [RTECS# LT0325000) [HR: H2 F2) CL3A,IR 0.0220 ·Gins CLV Control Area 2 -New Haz Mat Locations 416 42087-80-9 s 417 96-33-3 L 418 67-56-1 L 419 67-56-1 L 420 547-58-0 s 421 3878-55-5 s 422 75-18-3 L 423 55112-42-0 s 424 75-65-0 L 100 Methyl 4-Chloro-2-Nitrobenzoate [MP 43oCJ [Aldrich 217352] [HR: H1] 100 >/=50 Methyl Aaylate [Methy! 2_.Propenoate) [Propenoic Acid Methyl Ester) [Methyl Propenate] [MP -75oC; BP 80oC; FP 44oF] [LEL 2.1; UEL 14.5] [SG 0.956; VD 3] [LD50-0: 277 mg/kg; LD50-S: 1243 mg/kg; LC50: 1350 ppm/4H] [RTECS# AT2800000] [HR: H3 F3 R2 COR) Methyl Alcohol [Methanol][Wood Se~ler] [Pen Fix] [Reagent Alcohol] [Blue Blox] [MEOH] [FP 52oF; BP 64.7oC/148oFJ [LEL: 6%; UEL: 36.5%] [Autoignition: 878oF] [VP 100mm @21.2oC] [SG'0.791; VD 1.109} [FV per Glm 1270j [HR: H2,F3] IR CR, FL1B, TX, OHH, UR2 FL1B, IR >/=50 Methyl Alcohol [Methanol] [Wood Sealer} [Pen Fix] [Reagent Alcohoij [Blue Blox] FL 1 B, IR [MEOHJ [FP 52oF; BP 64.7oC/148oF] [LEL: 6%1 UEL: 36.5%] [Autoignition: 878oFJ [VP 100mm @2t2oC] [SG 0.791; VD 1.109] [FV per Gin: 1~70} [HR: H2 F3] 100 Methyl Orange [Acid Orange 52] [C.1.13025) [4-(4-IR, OHH, TX Dimethylaminophenylazo)Benzenesulfonic Acid Sodium Salt] [LD50-0: 60 1119/kg] [RTECS# DB6327000] [Aldrich 114510] [HR: H3] 100 Methyl Succinate [mono-Methyl Succinate] [MP 56oC; BP 151oC; FP None] [Af<!rich IR M81101][HR: H1] 100 Methyl Sulfide [Dimethyl Sulfide] [2-Thiopropane] [BP 99.3oF; FP-34oF) [L~L 2.2; FL 1A, IR UEL 19.7] [SG 0.846; VD 2'1] [RTECS# PV5075000] [HR: H2 F4) 190 Methyl-1-Piperazlnecarbonyl Chloride Hydrochloride (4-) [MP 225oC) [Aldrich 515027] [HR: H3R1 COR] CR,WR1 100 Methyl-2-Propanol (2-) [tert-Butyl Alcohol][tert-Butanoij [tert:Butyl Hy~roxlde) [1, 1-FL1B, IR Dimethylethanol] [frimethylcarbinol] [BP 83oC; FP 53oF] [VD: 2.565; SG: 0.781; LEL: 2.4; UEL: 8) [RTECS# E01925000) (HR: H2 F3] 0.0550 Lbs 0,0661 Gins y FLV 8.0000 Gins y FLV 0.0528 Gins FLV 4.4200 Lbs 0.0550 Lbs· 0.0220 Gins Y FLV 0.0550 Lbs 0.1321 Gins Y FLV Control Area 2 -New Haz Matlocations Control Area-2-New Haz Mat Locations C!llltrof Area 2·-New Haz Mat Locations Control Area 2 -~isting Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control/\rea 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat ~ocations LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions .. CLV-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. -Not all materials are In use at the same time, with <1 Oo/. In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L103, Magnet Room/L109, Mass Spectrometry Lab/L1'10, Robotics Lab/L101, Refrigerator/L103 New Haz Mat Locations: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building Is protected .throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 29 - <' -. --,.--~~ . c.. ·""'-I~,_.-._.....,,,_,': . .::.:;....-.. ~~--; .. ,J ~ -:: -·-~-----.. : .• Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherfor~, Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory . . Item,: CAS# ;-:-., ·::· .. s~tati~--Coitco/; '. M~t~ri~t.\: .. ::· . --,,-•.i:'-,:; -. · . .-Hazard Class. •• •• ~. : • '· •• ,., ,.: -• • ·---· __ :,_; ___ :. ~· • • • • • • > ••• .!. • J • ••• • .. 425 872-50-4 L . 100 Methyl-2-Pyrrolidinone (1-) [N-Methyl-2~Pyrrolidone) [NMP] [Methylpyrrolldone] [1· CL3A, IR Methyl-5-Pyrrolidone] [M-Pyrol] [Microslrlp 2001] [Cyclic Amine] (Rim Mold Clnr] 426 867-44-7 s 427 99.75.3 s 428 109-83-1 L 429 89-92-9 L 430 60-34-4 L 431 616-47-7 •. L 432 109-0?-4 L 433 115-11-7 LG 434 109-08-0 L 435 120-94-5 L 436 74470-23-8 __ . s 437 3908-55-2 L 438 20667-19-0 s [LD50: 3914 mg/kg; Skin LD50: 8 gm/kg) [TOT: CNS, MSS, Beine) [FP 187-396oF) [HR: H2F2] 100 Methyl-2-Thlopseudourea Sulfate (2·) [MP 240oC] [RTECS# UM9200000) [HR: H1) IR 100 Melhyl-4-Hydroxybenzoate [p-Hydroxybenzoic Add Methyl Es!er) [Methyl Paraben] IR [MP 126oC) [RTECS# DH2450000] [HR: H2] . 100 Methylamlnoethanol (2·) [N-Methylethanolamlne) [BP 159oC; FP 163oF] [LDS0-O: CL3A, CR 2430 mg/kg] [RTCS# KL6650000] [HR: H3 F2 COR] 100 Methylbenzyl Bromide(2-) [a0Bromo-o-Xylene] [MP 18oC;·BP 2160; FP 180oF] [HR: CL3A, CR, OHH H3F2COR] 100 Methylhydrazine [Monomethylhydrazlne] [BP-189oF; FP 62oF [LEL 2.5; UEL 97] [SG CR, FL 1B, HT, 0.866; VD 1.594] [LD50-O 32 mg/kg; LD50-S 68 ppm] [RTECS# MV5600000] [HR: UR1, PSM, P65, H4 F3 R1 COR]. RMP-T1,RMP-T3 100 Methylimldazole (1-) (n-Melhylimldlazole] [MP-60oF; BP 198oC; FP 198oF] [RTECS# N17000000] [HR: H3·F2 COR] CL3A,CR 100 Methylmorpholine (4-) [N-Methylmorpholine) [BP 115oC; FP75oF] [pH 10.6] [VD 3.5; CR, FL 1C SG 0.92] [LFL 3) [RTECS# QE5775000] [HR: H3 F3 COR] 100 Met~ylpropene (2·) (lsobutylene] [lsobutene] [mw, 56.12] (6.8 cf/lb] (l:C50: >2000 ppm • asphyslant] [MP-1400; BP -7.9o/760mm] [LEL 1.6] [VD 2) [RTECS# UD0890000) [l-1R: H3 F3] - FG, OHH, RMP-T2 100 Methylpyrazine (2-) [MP-29Oc; BP 1350; FP 1220!] [rtecs# uq3675000] [HR: F2 H2] CL2, IR 100 Methylpyrrolidone (1·) [BP 80oC; FP -7oF] [SG 0.819] [RTECS# UY1420500] [HR: CR, FL1B H3F3COR] 100 Methyllhlonlcotinic Acid (2·) (2-(Methyllhio)Nicotinlc Acid] [MP 215oC] [HR: H1] 100 Methylthiotrimethylsllane [(Methylthlo)Trimethylsilane] [BP 110oC;·FP 38oF; SG 0.848] [Aldrich 359491l[HR: H2 F3 R1J 100 'Melhyltriphenylphosphonium Iodide [HR: H2 R1] IR FL1B, IR, WR1 IR,WR1 S~orage ·units :: Cabs. LEV Location 5.6005 Gins CLV Control Area 2 • New Haz Mat Locations 0.2202 Lbs Control Area 2 • New Haz Mat Locations 1.1013 Lbs Control Area 2 • New Haz Mat Locations 0.1321 Gins CLV Control Area 2 • New Haz Mat Locations 0.0550 Gins CLV Control Area 2 -New Haz Mat Locations 0.0220 Gins Y FL V Control Area 2 • New Haz Mat Locations 0.0484 Gins CL V Control Area 2 -New Haz Mat l:ocatlons 0.1057 Gins Y FLV Control Area 2 • New Haz Mat Locations 10.0000 Cf Control Area 2 • N.ew Haz Mat Locations 0.0220 Gins Cl:. V Control Area 2 • New Haz Mat Locations 1.0567 Gins Y FLV Control Area 2. New Haz Mal Locations 0.2202 Lbs Control Area 2 • New Haz Mal Locations 0.0013 'Gins Y FLV Control Area 2 • New Haz Mat Locations 0.0550 Lbs Control Area 2 • New Haz Mal Locations -------------------------------------------------------------------------------------·---· ---- LEV: !-ocal or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% In use at any time. Contr9l Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusls: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 30 - . :.::.:.:; .. -- ··-g,_, ,,;,7. ~ ~ ""'-'¾- >?..---.,-·· :·:-· .. , ....... ··,. _1:,1 _, ~,........ ___ . _ __.; --.....t".h,J j.jJ -.. -.. ------ isis Pharmaceuticals/Ibis Laboratory-1891 Rutherford, Carlsbad CA-Control Area·2/Labs: · Hazardous Materials lnventoi:y -Item C~#: ·:-.--·:· ... State'·;-,C~nc%'·Matei1111/:;:·.-> .,, l:fazard·tlass Storage ,Units Ca~s LEV. Location . : . . ,•. _, --. ..._ ___ .. _·_· -~---··-' _ .. _:. ____ . . - 439 500-44-7* L 440 8042-47-5 L </=50 Mimosine (Leucenol] Aqueous Solution -FP·None] [RTECS# UT7610000] [HR:-H1] OHH >/=70 Mineral Oil [Compressor Oiij (Duoprime Oil 70) [Acoprime Oil 70] [Ardox 4529A] [Cutting Fl~!~] [FP 215-335oF] [HR: F1] CL3B <i.2642 Gins Control Area 2 -New Haz Mat Locations 0.2642 Gins Control Area 2 .-New Haz Mat Locatio.ns --~-----------~---------'----------------------·-----··------ 441 8032-32-4 L 442 70955-01-0 s 443 1132-6.1°2 s 444 84082-64-4 s 445 100684-32-0 s 446 544-63-8 s 447 389-08-2 s 448 86-86-2 ·s 449 2243-83-6 s 450 1405-10-3 s 451 7440-02-0 s 452 7791-20-0 s 453 7697-37 °2 •. L 454 .645-12-5 s 100 Mineral Spirits [Petroleum Ether] [Safety-Kleen 105] [Solvent-MS 6617) [VM&P CL2, IR Na1>htha] [FP 1Q5oF; BP 310oC; SG: 0.775-0.795; VP: 4.9] (i:EL 0.7/UEL 6:0J [HR: m~ . 100 Molecular Sieves [3N4AJ [Aldrich 334308 etaij [HR: H1] JR 100 MOPS [4-Morphollno'f'ropanesulfonicAcld] [MP 277oC] [RTECS# QE91045330] IR ~~ . 100 Mucin [Sigma M1778] [HR: OJ NH 100 MyO!!lobln [Sigma M1882 et al] [HR: H1) IR 100 MyristicAcid [MP 55.1oC; BP 250oC/100mm; FP >230oF) [LD50-O >10.g/kg] IR [RTECS# QH4375000) [HR: H2], 100 NalklixicAcid [1,4-Dlhydro-1-Ethyl-7.Methyl-4-0xo-1,7-Naphthyridine-3-Carboxylic CA, IR, OHH,P65 Acid Sodum Salt] [RTECS# QN2885500] [HR: H2] 100 Naphthaleneacetainlde (a-) [1-Naphthaleneacetamidej [HR: H2] IR. 100 Naphthoyl Chloride (24 [MP 52oC; e·p 160oC/11mm; FP >230oF] [Al~rich CR; WR1 250260][HR: H3 R1 COR] 100 Neomycin Sulfate [Mycalfradin Sulfate] [Neomix] [Olobiotic] [RTECS# QP4375000) IR, OHH, P65 [HR:H2] 100 Nickel [Powder][Raney Nickeij [RTECS#.QR5950000][HR: H2 F1) CA,.CD, IR, OHH, SN,P65 100 Nickel(II) Chloride Hexahydrale [RTECS# QR6475000] [HR: H2) CA, IR, OHH, P65 41-85 Nitric Acid [41% to 85%] [HNO3] [Acid) [SB-RO 150 Acid] [pH: <1) [FP None] [LOSO-CR, OX2, P$M, 0 >500 mg/kgl[RTECS# QU5900000] [HR: H3 COR OX] RMPsT1, RMP-T3 100 Nitro-1-FurolcAcid (5-)[MP 1860] [RTECS# LV2012000] [HR: H1] IR 2.1134 Gins CLV Control·Area 2-New Haz Mat Locations ----------·---------- 12.1513 tbs Control Area 2 -New Haz Mat Locations. 0.5507 Lbs Control Area 2 -New Haz Mat Locations 0.0220 Lbs Control Area 2 -New Haz Mat Locations 1.1013 lbs Control Area 2 -New Haz Mat Locations 0:2202 Lbs Control Area 2 --New Haz Mat Locations 0.2753 Lbs Control Area 2 -New Haz Mal Locations 0.0550 Lbs Control Area'2,-New Haz Mal Locations 0.1101 lbs Control Area 2 -New Haz Mat L<icaUons 0.2753 Lbs Control Area 2 -New Haz Mat Locations 2.3347 Lbs Control Area 2 -New Haz Mat Locations 0.0220 Lbs Control Area 2 -N11w Haz Mat Locations 1.1889 Gins Control Area 2 -New Haz Mat Locations 0.0550 Lbs Control Area 2 -New Haz Mat Locations LEV: Local or generalfarea exhaust ventilation required for Class I, II and lll·A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount = Maximum/total amount In. use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% in use at any time. Control Area 2: Entire bulidlng, excluding Chemical Waste Storage/Rooms L114 '-L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Ro9m/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101·, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustlble Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Bulldlng Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS. ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001-PAGE 31 - ---t--. Ce' .-:~-~--~.:._~ __ :_:: .... ..:: ••• --~ -: ----·--'"·- ,· Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherforc;t, Carlsbad CA -Control Area 2/Labs: Hazardous Materials Inventory - Item· CAS# , .· _.:' ,:~~te.~--~~n~¾ ,'!'!'~te~lal._ .::~(· · .. ~ ... ... : Hazar(f Class · Storage Units Cabs LEV · Location 455 99-61-6 s 100 . Nitrobenzaklehyde (3-).[MP 57oC) [RTECS# CU7350000) [HR: H2] IR 0.0220 Lbs Control Area-2 -New Haz Mat Locations -------- 456 555-16:S s 100 Nitrobenzaldehyde (4-) [MP 105oC) [RTECS# CU7350000) [HR: H2) IR 0.2202 Lb~ Control Area 2 -New Haz Mat L0Cc1tions ------- 457 5455-59-4 s 100 Nitrobenzenesulfonamide (2-) [MP 190oC) [Aldrich 228907) [HR: H2] IR 0.05~0 Lbs Control Area 2 -New Haz Mat Locations 458 6325-93-5 s 100 Nitrobenzenesulfonamide (4-) [MP 178oC) [RTCS# D82975000] [Aldrich 120502] IR 0.1101 Lbs Control Area 2 -New Ha?, Mat Locations [HR:H2) 459 1694-92-4 s 100 _-:·. Nitrobenzenesulfonyl Chloride (2-) [MP 65oC] [Aldrich N11507] [HR: H3 R1 COR] CR,WR1. 0.2202 Lbs Control Area 2 -New Haz Mat Locations 460 98-74-8 s 100 Nilrobenzenesulfonyl Chloride (4-) {MP 76oC] [Aklrich 372248] [HR: H3 R1 COR) CR,WR1 0.0771 Lbs Control Area 2 -New Haz Mat locations --------·· ----~-- 461 121-92'6 s 1_00 Nitrobenzoic.Acld (3-) {MP 140oC] (RTECS# DH500000) [HR: H2] IR 0.2202 Lbs Control Area 2 -New Haz Mat Locations 462 3958-57-4 s 100 Nitrobenzyl Bromide (3-) [alpha-brorno-3-nitrotqluene] [Aldrich 2225181 {MP 48oC] · CR 0.0110 Lbs Control Area 2 -New Ha?: Mat locations . [HR: H3 COR] 463 100-11-8 s 100 Nitrol/enzyl Bromide(4-) [a-Bromo-4-Nitrotoluene] {MP 98oC] [RTECS# SX7967000] CR, OHH 0.0110 lbs Control Area 2 -New Haz Mat locations [HR:H3COR] 464 555"68-0 s 100 NitrocinnamlcAcid (3-) [MP; 202oC] [RTECS# GE0325000] [HR: H2] IR 0.0660 lbs Control Area 2 -New Hat Mat Locations 465 77~7-37-9C C 100 Nitrogen [Cryogenic] [LN2J [13.8 cfnb; 93.11 cf/gin] [HR: H2J NH 128.0000 Gins Control Area 2 -Existing Haz. Mat Locations 466 7727-37-9C C 100 Nitrogen (Cryogenic] [LN2) (13.8 cf/lb; 93.11 cf/gin] [HR: H2) NH 253.6000 -Gins Control Area 2 -New Haz Mat Locations 467 75-52:5 L 100 Nitromeihane [Detonatable] [MP-290; BP 101oC; FP 95oF] [LEL 7.3] [SG 1.127; VD FL 1C, IR, UR3, 0.7925 Gins y . FLV Control Area 2 -New Haz Mat Locations 2.1] [LD50-0 940 mg/kg] [RTECS# PA9800000) [HR: H2 F3 R4) PSM,P65 . . . 468 65-86-1 s 100 Nitroorotic Acid (5-) i6-Carboxy:2,4-dihydroxypyrimldine] [Oro~c acid Anhydrous) OHH 0.5507 Lbs Control Area 2 -New Haz Mat Locations [Uracil-6-carboxylic acid) [LD50-0 2 gm/kg) [RTECS# RM3180000) [Sigma 01756) [HR:H1] 469 60779-49-9 s 100 Nitroorotlc Acid Potassium Salt Monohydrate (5-) [MP >300oC) [HR: H1] IR 0.1101 Lbs Control Area 2 -New Haz Mat Locations 470 7693-46-1 s 100 Nitrophenyl Chloroformate (4-) [MP 77oC) [HR: H3 R1 COR WR) CR, WR1 1.0000 Lbs Control Area 2 -New Haz Mat Locations 471 3320-86-3 s 100 Nitrophenyl Isocyanate (2-) [MP 49oC] [BP 135o/17mm; FP >230oF) [Aldrich IR,SN,WR1 0.2202 lbs Control Area 2 -New Haz Mat Locations 269409) [HR: H1 R1) LEV: Local or general/area exhaust ventilation required-for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLV-Flammable Liquid Vapor. Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Not all materials are in use at the s~me time, with <10'/4 in use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/RoomsU14·& L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash lab/L 113, Open Lab/L 107 CombustibJe Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use<losed system conditions only. Building is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 32 - -~ -· .. ,_ "'.<·-, .. ,._,,,_-*;-,-,,·;,e.· " ..... ;-····,-1 -~--., ..._, ---~ ~ ~£:'"~ ifl,..:if: ,,. • .,.~ ___ .. _ _: -· :· ...... ,.J ,..:...; -. -' 111111 -·------- Isis Pharmaceuticals/Ibis Laboratory :.. 1891 Rutherford, Carlsbad CA -Control Area 2/Labs: Hazardous Materials Inventory ~em .. :c~_f., ,;:;, ... ·.~~t~,-'~~ni:~/;_'.~,Jef.1~1 ~-T~·.;,? · .. ·: = .... . ·.:-,-., Hazard Class :,: : Stpnig~ Units· Cabs LEV · Location .. _,. . ·,:·, _... . . 517 1314-15-4 S 100 Platinum(IV) Oxide [Adams Catalyst) [MP 450oC) [Aldrich 459925) (HR: H2) .JR 0.0022 Lbs Control Area 2 -New Haz Mat Locations -------------~----~'--'~----------~-----~-------------~----,-------------------- 518 9002-89-5 519 . 25322-68-3 .. 520 9002-98-6 521 9036-19-5 , 522 9002-92-0 523 28086-43-3 524 127-08-2 525 298-14-6 526 584-08-7 527 7447-40-7* 528 7447-40-7 529 7789-23-3* 530 7789-23-3 s s L L s s s ·S s L s L s 100 Poly(Vinyl Alcohol) iMowlol 40-88) [Gelvatol) [Polyvinyl Alcohol Resin) [PVA) [RTECS# TR8100000] [HR: F2) CD 100 Polyethylene Glycol [PEG) [Poly(Ethylene Oxide)] (Carbowax) [Polyox) (Pluracol P-IR, OHH 410] (AID 581oF -Powder) [LD50-0: 28 gm/kg; LD50-S >20.gm/kg] [Aldrich 181986) [RTECS# TQ4120000] [HR: H1) 100 P!)lyethylenlmine [Polymin P) (Aqueous Solution) (FP >230oC) (LD50-0 3300 mg/kg] CL3B, IR [RTECS# TQ7700000] [HR: H2 F1) 100 Polyoxyethylene Octyl Phenol (10') [Nonklet P-40] [lgepal-CA-630] [Non-Ionic CL3B, IR Detergent) [(Octylphenoxy)polyelhoxyethanol) (FP >200oF] (LD50-O4190 mg/kg] [RTECS# MD0907600] [Sigma 13021, et al] [HR: H1 F1) 100 Polyoxyethylene Sorbitan Monolaurate [Laury! Ether] [Theslt] [a-Dedecyl-a-Hydmxy-IR Polyoxyethylene] [Brij 30) [Brij 35) [Polidocanol} (Lubroij [BP >230oF] [HR: H2] 100 Polyuridyiic Ack! Potassium Salt (5'-) [Poly(D)] (Sigma P9528] [HR: H1J 100 Potassium A~tate (Acetic Acid Potassium Salt] [Aldrich 255785 etall[RTECS# Ad3325000) [HR: H2) . 100 Potassium Bicarbonate [P9tassium Hydrogen Carbonate) [HR: OJ 100 -Potassium Carbonate [MP 891oC) [RTECS# TS7750000) [HR: H2] IR IR NH IR </=50 Potassium Chloride [Electrode Filling Solution] (Carbonate Chloride Transfer Buffer). IR [Potassium Reference Standartl Soluflon) [HR: H1) 100 Potassium Chloride [Potash) [Turf Supreme w/Beslcote 15-5-7; 20--0-20; 6-20-20] IR, OHH [Ultra King Greens Cote 18-4-10] [with </=2% Iron Oxide) [pH 9.2) (LD50-O 2600 mg/kg) [RTECS# TS8050000)[HR: H1) </=90' Potassium Flouride [Aqu_eous Solution -FP None] [LD50-O: </=270 mg/kg) CR, OHH, TX [RTECS#: TT0700000) [HR: H3 COR) 100 Potassium Flouride [MP 8580) [LD50-O: 245 mg/kg) [RTECS#: TT0700000) [HR: H3 CR, OHH, TX CORI 0.5507 Lbs 2.2026 Lbs 0.0220 Gins 0.0264 Gins 0.8811 Lbs 0:0220 Lbs 3.3040 Lbs ·0,2202 Lbs 20.9251 Lbs 0.4284 Gins 6.6153 Lbs Q.1321 Gins 0:2202 Lbs Control Area 2 -New Haz Mat LocaUons Control-Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New.Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area ? -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations· Control Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations Controi'Area 2 -New Haz Mat Locations Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use:.Open conditions. CLY-Combustible Liquld·Vapor. FLY-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz ~at Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 CombustlbJe Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building i~ protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC.· 11/13/2001 -PAGE 36 - --... •('-fi:;7"-ftl-<'·,-~,-·-~o·•,>r,• .,.·., -.,_ , .. ,. -·-,. -· -· _: ~~ ~ •~ , ;{~~;£ £~, ·,:_ .............. ___ .) _ -----,! +-J..J • ~ r·---i --·• ~ -----------· Isis Pharmace_uticals/lbi~ Laboratory-1891 Rutherford;_Carlsbad·CA -Control Area 2/Labs: Hazardous Materials Inventory lteltl: CAS#-:; .. .-: : State' :,Coric%:1.Mat~rlal · .... ·. ·. • ~-• -. • • • ,,! • • ' ' • ,.,,_. • • •, . __ : Haza~~ Class Storas,e Units· Cabs LEV Location 531-7646-93-7 s 100 Potassium Hydrogen Sulfate [Potassium Blsulfate] [HR: H2] IR 1.1013 Lbs Control Area 2 -New Haz Mat Locations ____ NO ___ .., __ , ____ 532 1310-58-3* L >/=71 to Pota.sslum Hydroxide [>/=71% Solution In Water] [Ardox PC4529] [Hydro 1000] CR, TX,WR1 0.2666 Gins Control Area 2 -New Haz Mat Locations </=85 [Hydro 1500] [LD50-0ral@ 75%: 500 mg/kg] [BP 2408oF; FP None] [HR: H3 R1 COR] 533 1310-58-3 .. s >/=85 Potassium Hydroxide [Caustic Potash) [Caustic-Base] [LD50-0ral: 365 mg/kg) [KOH} CR, TX, WR2 16.7548 Lbs y Control Area 2 -New Haz Mat Locations [RTECS# TT2100000J [pH: 12} [HR: H3 R2 COR WR}. 534 7757-79-1 s 100 Polassium Nitrate [Saltpeter] [Potassium Nitrate 13-0-46) (Potassium Nitrate 13.75-0-IR, OX1 1.1013 Lbs Control Area 2 -New Haz Mat Locations 44.5) [HR: H1 OX} 535 7722-64-7 s 100 Potassium Permanganate (MACuDizer9275] [MacOermid 19275) [RTECS# GR,OX2 1.1013 Lbs Control Area 2 -New Haz.Mat Locations SD6475000] [HR: H3 COR OX} 536 7778-53-2* , L 20 Potassium Phosphate [Aqueous Solution] (Omnibond Plus 269] [pH: 13] [FP None] CR 0.1321 Gins Control Area 2 -New Haz Mat Locations (RTECS# TC8450000] [HR:. H2CORJ 537 7778-53-2 s 100 Po!ilsslum Phosphate fTripotasslum Phosphate] [RTECS# TC8450000] [HR: H3 CR 1.1.4611 Lbs Con.trol Area 2 -New Haz Mat Locations COR] -~::" . . . •. ·-·- 538 7778-77-0 ,. s 100 Potassium Phosphate Monobasic [Potassium Dihydrogen Phosphate) [Phosphate IR 3.3040 Lbs Control ~rea 2 -New Haz Mat Locations Buffer] [KH2 P04] [RTECS# TC6615500] [HR: H1] ·---- 539 865-47-4 ·s 100 Potassium tert-Butoxlde [Base] [MP 256oC] [Aldrich 156671] [HR: H2 F2 R2 COR CR,FS,WR2 0.2202 Lbs y Control Area 2 -New Haz Mat Locations WR) 540 10387-40-3 s 109 Potassium Thioacetate [Potassium Thiolacetate] [MP 173oC] [Aldrich 241776) [HR: IR,WR1 0.0550 Lbs Control Area 2 -New Haz Mat Locations H2R1) 541 63-45-6 s 100 P_rimaqulne Diphosphate [6-{4-Amlno-1-Methylbutylaml!Jo)-6-Methoxyqulnollne] [MP TX 205oC) ().050-0: m mg/kg] [RTECS# VA9660000] [HR: H2J 0.0220 Lbs Control Area 2 -New Haz Mat Locations 54~ 107-10-8 L 100 Propylamine {1-Aminopropane] [Monopropylamine) !1-Propanamine) [E!P 48oC; FP -CR, FL 1B, TX 0.0925 Gins y FLV Control Area 2 -New Haz Mat Locations 35oF] [LD50-S: 560 mg/kg; LC50-0: >570 mg/kg; LC50: 4320 ppm] [LEL 2; UEl 10.4) [SG 0.717; VD 2.045] [RTECS# UH9100000] [HR: H3 F3 COR] 543 98-97-5 s 100 PyrazinecarboxylicActd (2-) [Mp 225oC) [Aldrich P56100) [HR:H1) IR 0.0550-Lbs Control Area 2 -New Haz Mat Locations 544 288-13-1 s 100 Pyrazole [LD50-0: 1010 mg/kg] [RTECS# UG4900000) [HR: H2) IR,OHH 0.1101 Lbs Control Area 2 -New Haz Mal Locations •, '• LEV: Local or general/area exhaust ventilation required for Class·t, II and Ill-A l.:lqulds use-open conditions. CLY-Combustible Liquid'Vapor. FLY-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical-Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/I., 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L 120, Glasswash Lal:I/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. • 11/13/2001 • PAGE 37 --- : L-:-~=-· ~;,-~ ,-.···-1IIIIL· -----'· ---? -·: -:-:·---. -' ... ...:-.:;.. ~. ~~..:;1'".-.,;_....._ __ ~ ,_.. ·-·--~-., -.... ~ .._ -~ ·-~ .... ,. Isis Pharmaceuticals/Ibis Laboratory-1891 Rutherford, Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory Item_· CAS# ·. ··. • .. f · ..... S~te:_-Cone%· Material ~-' Hazard Cl~s~ storage Un.Its Ca~s ·LEV · Loc;atlon, . . . . . ~ . . . 472 369-07;3 s 100 Nitrophenyl-b-0-Galactopyranoside (2') [MP 195oCJ [Aldrich N21502) [HR: H1] IR ,iJ.1101 Lbs ·control Area 2 -New HaZMat Locations 473 13331-27-6 s 100 Nitrophenylboronic Acid (3-) [3-Nitrobenzeneboronlc Acid) [HR: H2) IR .0.0022 Lbs Control Aiea 2 -New Haz Mat Locations --- · 474 603-62-3 s 100 Nltrophthalimide (3-) [MP 213oC) [Aldrich 41:.\034) [HR: H2] IR 0:1432 Lbs Control Area 2 -New Haz Mat Locations 475 89-40-7 s 100 Nitrophthalimide (4-) [MP 200oC] [RTECS# Tl5625000) (HR: H2) IR 0.0550 Lbs Control Area 2 -New Haz Mat Locations 476 89-58-7 s 100 Nitro-p-Xylene [1,4-Dlmethyl-2-Nltrobenzene] [Nitro-para-Xylene) [LDS0-0: 2440 OHH 0.2202 Lbs Control Area 2 -New H\!Z Mat Locations mg/kg) [Aldrich S380059) [HR: H2) 477 85-38-1 s 100 NltroslllicyclicAcld (3--) [2Hydroxy-3nitrobenzoic acid) [MP 142oCJ [Fluka 73815] IR 0.1642 Lbs Control Area 2 -New Haz Mat Locations [HR: H1] 478 611-08-5 s 100 Nltrouracil (5-) [MP >300oC) [Aldrich 852767] [HR: OJ NH 0.0550 Lbs Control Area 2 -New Haz Mat Locations --· 479 1476-53--5 s 100 • Novoblocin Sodium Salt [MP 215oC) [LD50-0 3500 mg/kg) [RTECS# RD5425000] IR,OHH,SN 0.0,110 Lbs Control Area 2 -New·Haz Mat Locations [Sigma N6150) [HR:-H2) 480 6409-77'4 s 100· Nuclear Fast Red (Calcium Red] {Cl 60760] (Aldrich 229113) (HR: H2) IR 0.0110 Lbs Control Area 2 -New Haz Mat Locations 481 124-30-1 s 100 Octadecylamine [Stearylamine] [MP 5_5oC; FP >230oFJ [RTECS# RG4150000j [HR: CR, OHH 0.0550 Lbs Control Area 2 -New Haz Mat Locations H2COR] 482' 9006-59-1 ·S 100 OValbumin [Albumin from Chicken Egg] [HR: OJ · NH 0.2202 Lbs Control Area 2 -New Haz Mat Locations 483 79;37-a L 100 Oxalyl Chloride [MP. 10oC; BP 53oC; F.P None] [LC50: 1840 ppm/1H) [RTECS# CR,OHH, rx; WR2 0.0264 Gins . y Control Area 2 -New Haz Mat Locations Kl2950000) [HR: H3 R2 COR WR) 484 14698•29-4 s 100 Oxolinic Acid [MP 314oC) [LD50-0 525 mg/kg) [RTECS# Jl5075000] [Sigma 00877] IR 0:0110 Lbs Control Area 2·-New Haz Mat Locations [HR:H2] 485 60792-79-2 s 100 Oxybis(Ethylamlne) Dihydrochloride (2,2'-) [2-Aminoethyl Ether Dihydrochloride] [MP IR 0.0132 ~bs Control Area 2·-New Haz Mat Locations 232oC] [HR: H1) 486 7782-44-7~ C 100 Oxygen [aw: 32.00][115.1 cf/gin;, 12.08 cf/lb] [HR:.OXG] ox 45.0000 Gins Control· Area 2 -Existing Haz Mal: Locations 487 3375-31-3 ,. s 100 Paliadium(II) Acetate [RTECS# AJ1900000] [HR: H1] IR 0.0220 Lbs Control Area 2 -New Haz Mat Locations 488 30525-89-4 s 100 Paraformaldehyde [MP 163-165oC; FP·158oF) [LD50-0 800 mg/kg; LD50-S72 g/kg; FS, iR, OHH, SN, 0.2202 Lbs Control Area 2 -New Haz Mat Locations LC50 11742 ppm) [RTECS# RV0540000) (HR: H3 F2J TX ------. ·--- LEV: Local or general/area e)!:haust ventilation required for Class I, II @nd Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms-L114 & L117. Existing Haz·Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 33 -::; ---·· ,_ ~-,,,,_,: lllllla.E' l Lallllllll~~-c;i [E -L~~~---_ .... _ __:_;_<_, .. ~ 111111.:] ____ J _____ .:_: -····--: __ . _. .!1!1111!!1 :_ .. __ Isis Pharmaceuticals/Ibis Laboratory-1891 Rutherford, Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory; Item:-: .CAStl ;-_.'.. : .-· State: tohc'Y.' ,:M~teri~I :.:, ,1.::\>::.-,. . ,, : -Hazarifclass :-' . Storage Units_ ~~ .'. ,.= Cabs -._EV Location 0, •. V > <', ' 0 > 0 ' ,',, •••J" • ... .:.., . 489 1263-89-4 s 100 Paromomycln Sulfate [Sigma P9297) [HR: H1) IR 0.0550 tbs Control Area 2 -New Haz Mat Locations --·--- 490 629--62-9 L 100 Pentadecane (N-).[BP270o; FP 270oF] [RTECS# RZ1800000) [HR: H2 F1] CL38, IR 0.0055 Gins Control Area 2 -New Haz Mat Locations - 491 14533-84-7 L 100 Pentafluorophenyl Trifluoroacetate [Aldrich 377074] [BP 122oC; FP 126oF) [Aldrich CL2, IR, WR1 0.0550 Gins CJ.V Control Area 2 -New Haz Mat Locations 377074] [HR: H2,F2 R1) 492 109-66-0 L 100 Pentane [MP -130oC; BP 35oC; FP -57oF] [LFL 1.4; UFL 8 [SG 0.626; VO 2.497) FL1A, IR, OHH, 4.2268 Gins y FLV Control Area 2 -New Haz Mat Locations [LD50-0 >500 mg/kg; LC50 >2,000 ppm) [RTECS# RZ9450000) [HR: H2 F4) RMP-T2 493 7601-90-3 L >/=60 PerchloricAcld [Nondetonatable) [RTECS# SC7500000) [HR: H3 R1 COR OX) CR, OX3, WR1, 0.1321 Gins y Control Area 2 -New Haz Mat Locations PSM 494 1943-82-4 L '100 Phenethyl Isocyanate [BP 210oC; FP 212oF] [Aldrich 456179] [HR: H2 F1 R1] CL3B, IR, WR1 0.0110 Gins Control Area 2 -New Haz Mat Locations 495 108-95-2* L 50-90 Phenol [50-90% in Solution) [BP 180oc; FP 175oF) [LDS0-0: 500--666 mg/kg; LOSO-CL3A, CR, OHH, 0.0264 Gins CLV Control Area-2 -New Haz Mat Locations S: 769-1,338 mg/kg; LC50: 500-732 mg/m3 [HR: HJ F2) TX,RMP-T3 496 108-95-2 s 100 Phenol [Carbolic Acid) [MP 4QoC; FP 175oFJ [LD50-0: ~ 17 mg/kg; tD50:.S: 669 CR; FS, ORH, TX, 1.7621 Lbs Control Area 2 -New Hat Mat Locations mg/kg; LC50: 316 mg/m3] [RTECS# SJ3325000] [HR: HJ F2 CORI RMP-T3 497 Mix-248 L 100 PhenoVChloroform [40% PhenoV108-95-2, 40% Chlor'oforin/67--66-3) [HR: H3 F2 CA, CL3A, CR, 0.8430 Gins CLV Control-Area 2 -New Haz Mat Locations CORI OHH,TX 498 136112-00-0 ·L 100 Phenol:Chl6roform:lsoamyl Alcohol 125:24:1[Na0Ac] [pH 4.2-7,5] [Fluka 77619 -FP CL2, CR, OHH, 0.1277 Gins CLV Control Area 2 -New Haz Mat Locations Data based-on lsoamyl Alcohol] [HR:H3 F2 CORI SN, TX, P65, RMP- T1,RMP-T3 499 122-59-8 s 100 Phenoxyacetic Acid [MP 980) (LD50-0: 1500 mg/kg) [RTECS# AJ2230000) [HR: H2] IR 0.1101 Lbs Control Area 2 • New Haz Mat Locations 500 103-71-9 L 100 Phenyi Isocyanate [lsocyanatobenzene) (MP-30oC; 8P 1620; FP 13?oFJ [LD50-0: CL2, CR,HT 0.0220 Gins y CLV Control Area 2 -New Haz Mat Locations 40 mg/kg; LD50-S: 7130 mg/kg) [RTECS# DA3675000) [HR: HJ F2 COR] 501 3360-41--6 L 100 Phenyl-1-Butanol (4-) [BP 140oC/14mm; FP >230oF) (Aldrtch 184756} [HR: H2 F1) CL3B,IR 0.0617 Gins Control Area 2 -New Haz Mat Locations 502 122-97-4 L 100 Phenyl-1-Propanol (3-) (3-Phenylpropyl AIC!)hol)(MP-18o; BP 235Q; FP 229oF] CL3B, IR 1.1013 Gins -Control Area 2 • New Haz Mat Locations [RTECSX# UB8970000) [HR: H2 F1) 503 103-82-2 s 100 PhenylaceticAcid [Benzenacetic Acid] (MP 77oC) [Aldrich P16621) [RTECS# CR 0.2202 Lbs Control Area 2 -New Haz Mat Locations AJ2430000) [HR: H3 CORI LEV: Local or general/area exhaust ventilation required for Class.I, II and Ill-A Liquids use.open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <101/e in use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building is protected throughout_ by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001-PAGE 34 - -~ ----L-ltf;-....a -~ :'1--''f~ 'f.'-,··-··' --:-·1 Laalllt ~ . ,. ,~i\,; hi • ...Ar.:lr"""'~---·-·--_h .. J ,,..._.,...:,i ----::_ .. ----____ j. -~--- Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, ·Carlsbad CA -Control Area 2/Labs: Hazardous Materia!s Inventory· : 1teni"'.:cASfi:.-.:.::1:-' :stat~-\conc¾ ·iftateriar· :·.·:,;;>., .. ·'·-~-. ' . " :• . .. . -. .._.;_,·.· ... · ............. :. :. . .. . -~ ::-... .. '. •.\ ·. .. <H~rd. Cl.ass'··-: -.'Storag~ · Unl~s _-. Cabs LEV · Location . ,•• . . . . . . . 504 100-58-3 L-O.S.:3.0M Phenylmagneslum 13romkle {0.5M-3.0M Solution in Diethyl EtherorTetrahydrofuran] CR, FL1A, OHH, .0.0220 Gins y FLV Control Area 2 -New flaz Mat Lo_cations {FP -3 to -40oF] [HR: H3 F4 R2 W2 CORI UR2,WR2· --· -~---···-· ·-.- 505 92-54-6 L 100 Phenylpiperazine (1-)·{FP >230oF] {LOSO-Oral: 210 mg/kg; lD50-Skin: 140 mg/kg] CL3B,CR; HT !).0110 Gins y Control Area 2 -New Haz Mat Locations [RTECS# TM2625000) [HR: H4 F1 CORJ ·------------... ·--------- 506 75-44-5 CG 100 Phosgene {Dlphosgene] [mw: 98.91} {LC50-Human: 50-3200 mg/m3] [RTECS# HT,CR, WR1, 5.0000 · Cf y ·Control Area 2 • New Haz Mat Locations SY5600000] [HR: H4 R1 COR WR] PSM, RMP-T1, RMP-T3 507 4408-78-0 s 100 PhosphonoaceticAcld [MP 143oC) [Aldrich 284270) [HR: 1:12] IR 0.0220 Lbs Control Area 2 -New Haz Mat locations -H--·--··-- 508 7664-38-2· L >50 Phosphoric Acid [H3P04] [Porteln Assay) [BP 232oF; FP None· Aqueous Solution] CR 0.0026 Gins Control Area 2 -New Haz Mat Locations [Acid-Inorganic] {LD50-0: >4,400 mg/kg; LD50-S: >3,260 mg/kg] [pH: 1.5] [RTECS# TB6300000] [HR: H3 COR) 509 1314-56-3 s 100 Phosphorous Pent9xlde [P205] [MP 340oC] (LC50-lnhalation: 155 ppm; 1,217 CR,HT,WR2 28.6417 Lbs y Control Area 2 -New Haz Mat Locations mg/m3) [VP: 4.9; 10 mm @ 238oC; 1 mm @384oC) [HR: H4 R2 COR WR] 510 10026-13-8 s .100 Phosphorus Pentachloride [Pentachlorophosphorane) [Phosphorus Perchloride] [MP CR, WR2, RMP-T3 0.2202 Lbs y Control Area 2 -New Haz Mat Locations 179oC] [RTECS# TB6125000) [HR: H3 R2 COR WR] 511 88-95-9 L 100 Phthaloyl Dichloride {Phthaloyl CHioride) [MP 12oC; BP 3690; FP >230oF] [HR: H3 CL3B,CR 0.0220 Gins Control Area 2 -New Haz Mat Locations F1'C0R) 512 4702-13-0 s 100 Phthaloylglycine (Na) (1,3-Dioxo-2-lsoindolineacelic Acid] [MP 193oC) [Aldrich IR 0.2202 Lbs Control Area-2 -New Haz Mat Locations P40506] [HR: H1) . 513 6959-48-4 100 Plcolyl C~loride Hydrochloride (3-) (3-(Chlorome!hyl)Pyrk!ine) [MP 137oC] {LD50-0: CA,IR,TX. 0.1101 Lbs Control Area 2 -New Haz Mat Locations s 316 mg/kg) [RTECS# US7000000] [HR: H3) . -514 110-85:.0 s 100 Plperazlne [Hexahydropyrazlne] {LD50-0: 1,900 mg/kg] [RTECS# TK780000J [HR: IR 0.2202 Lbs Control Area 2 -New Haz Mat Locations H2J 515 110-89-4 L 100 Piperidine (Cyclopentimlne] [Hex~hydropyridine) [Pentamethyleneimine] [BP 106oC; CR, Fl 1B, TX, 0.8322 Gins y FLV Control Area 2 -New Haz Mat Locations FP 40oFJ [SG 0.861; VD 2.946 [LD50-0: 145 mg/kg; LD50-S: 320 mg/kg] (pH 12.6] RMPaT1, RMP-T3 [RTECS#'RM3500000] [HR: H3 F3 COR] ·--·-------- 516 120-57-0 s _100 Plperonal [3,4-Methylenedioxybenzaldehyde) [Piperonyl Aldehyde] [MP 35oC; BP IR,OHH,UR1 0.2202 Lbs Control Area 2 -New Haz Mat Locations 264oC; FP >230oF] [RTECS# T01575000] [HR: H2 R1) ---------- LEV: .Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyroptiorlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001-PAGE 35 - -.--·--.. .. L.. ~-frf.; . ~11111:allllll,;::.:~ . .:__J -~--; ·-,:.! 111111.] -: -.. '.-........ -Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory Hem. CAS# :' '. ·. · .. '.:. ·statf·. Conco/.·. M~teriai"' ... :-:.. ·. ). : ,.1 •• " . :· Haz'.ard Class . Storage Units Cabs LEV Location · '!:,', •,. ,. . . . .... . . ·, . . . . ., . . . ' .. . . :, . . .~ . . •: . .... . 545 110-86-1 L . 100 Pyridine [Azabenzene] [Azine] [MP 42oG; BP 115oC; FP 78oF) [SG 0.978; VD 2.72] FL 18, IR, OHH 2.3802 Gins y FLV Control Area 2 -New Haz Mat Locati<ms [LEL 1.8; UEL 12.4] [LD50-0: 891 mg/kg; LD50-S: 9010 mg/kg] [RTCS# UR8400000) [HR: H2 F3) 546 500-22-1 L 100 Pyridinecarboxyaldehyde (3-) [Nicotinaldehyde] [FP 140oF; BP 95oC; SG 1.135] CL3A,IR,SN 0.0066 Gins CLV Control-Area 2 -New Haz Mat Locations [Aldrich P62208) [HR: H2 F2] 547 ·24057-28-1* L </=50 Pyridium-p-Toluenesulfonate [MP 117oC] [Aldrich 232238j (Aqueous Solution· FP IR,WR1 0.0066 Gins Control Area 2 • New Haz Mat Locations None] [HR: H2 R1] 548 24057-28-1 s 100 Pyridium-p-Toluenesulfonate [MP 117oC] [Aldrich 232238] [HR: H2 R1] IR,WR1 1.8722 Lbs Control Area 2 -New Haz Mat Locations -----549 . 8876845-0 s 100 Pyrimldylthioacetic Acid (2-) [Aldrich 275530) [HR: H2] JR 0.0881 Lbs Control Area 2 -New Haz Mat Locations 550 634-97-9 s 100 Pyrrole-2-Carboxylic Acid [BP 204oC] [Aldrich P7-360-9] [HR: H2] IR 0.0110 Lbs Control Area 2 -New Haz Mat Locations 551 123-75-1 L 100 Pyrrolldine (Ai,acyclopentane) (Tetrahydropyrrole) [Pro~mlne) (Tetnnethyllmlne) [BP CR, FL1B, TX, 0.0264 Gins y FLV Control Area 2 -New Haz Mat Locations 87oC; FP 37oF] [LEL 1:6; UEL 10.6} [SG0.86; VD 2.45] [LD50-0:.300mg/kg] WR1 [RTECS# UX9650000] [HR: H3 F3 R1 WR) 552 23355.95,9 L 100 Pyrrolldinemettianol [(S)-{+)-2-] [L-Prolinol] [BP 74oC; FP 187oF) [HR:,H2 F2) CL3A,IR 6.0550 Gins CLV Control Area 2 -New Haz Mat Locations .553 1619-34-7 s 100 Quinuclldinol (3-) [MP 223oC) [HR: H3 COR] CR 0.0110 Lbs Control Area 2 -New Haz Mat Locations 554 98327-87-8 ·S 100 · Racemic-2,2'-Bis(Diphenylphosphlno)-1, 1-Blnaphthyl [HR: H 1] IR 0.0044 Lbs Control Area 2 -New Haz Mat Lqcations 555 13558-31-1 s 100 Rhodamlne 110.[MP >3000] [HR: H1) IR,OHH 0.5507 Lbs Control Area 2 -New Haz Mat Locations 556 73482-96-9 • s 100 Rhodlum(!J)·0ctanoate Dimer (Aldrich 442100] [HR: H1] IR. 0.0011 Lbs Contro1:Area 2 -New Haz Matlocatlons 557 9001-994 s 100 Rlbonuclease [Ribonuc!ease A] [Ribonuc!ease BJ [Ribonuclease CJ [RNaseA) NH 0.1101 lbs Control Area 2 -New Haz Mat Locations [RNaseB) [RNaseCJ (Sigma: R5250] (HR: OJ 558 120991-81-3 s 100 Ribonucleic Acid [Transfer Amino Acid-Specific Fractions -Tyrosine Specific) [Sigma NH 0.0661 Lbs Control Area 2 -New Haz Mal Location~ R0258) [HR: OJ 559 9014-25-9 s 100 Ribonucleic Acid Transferase (Transfer RNA] [tRNA) [HR: OJ NH 0,0220 Lbs Control Area 2 -New Haz Mat Locations 560 14808'60-7 s 100 Sand [Crystalline Quartz] [Silicon Oxide) [Pumice] [Emery) [Bentone) [Min-u-Sil 5ml NH 2.2026 Lbs Control Area 2 -New Haz Mat Locations [Minspar 4, 25, 7) [Novakup GG1) [Buffing Compount) [HR: OJ LEV: Local or geheral/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLV-Flammable Liquid Vapor. Storage Amount = Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same t!me, with <109/a In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109; Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 CombustibJe Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building ls protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY Cl,ASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 • PAGE 38 - ·:i:: _:, ,.,· ... ---r·-· ··e::lllilalilll _ _,,_,,,,. ··-·.,-·.;-·:') ----,_ ----(. ~--r;::-i--f;[~·--~..,..11!111----1--'-"-; -~-~ w;,,J ~ -J --=--. ~··· Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Carlsbad CA -Control Area 2/Labs: Hazardous Materials Inventory Item CAS#". :·;· .. · ~tate;.~.~n~~ 'M?terial -<: _ _:.·· --:·· ,, ·-.'.. Hazard Class . ,Storage Units Cabs LEV Location 561 302-84-1 S · 100 Serine (DL-) [MP 220oC][Aldrich S2597) [HR: H1) IR 0:0550 Lbs Control Area 2-NewHaz Mat Locations ---------- 562 56-45-1 S 100 Serine (L-)[(S)-(+)sSerine] [H-Ser-OH) [MP 2220 dee] [RTECS# VT8100000] [HR: OJ NH 0.4405 Lbs Control Area 2 -New Haz Mat Locations -~--- . 563 506-64-9 S 100 Sliver Cyanide [l050-0ral: 123 mg/kgl[RTECS# VW3850000][HR: H3] IR, TX 0.2202 Lbs Control Area 2-New Haz Mat Locations -------- 564 TT61-88-8 S 100 Silve~I) Nitrat~ [MP 212oCl[RTECS# VW4725000) [HR: H3 COR OX] _ CR, OX1 0.1652 Lbs Control Area 27 New Haz Mat Locations 565 7440-23-5 S 100 Sodium [FP 128oF; MP 97.SoC) [RTECS# VY0686000] [HR: H3 F2 R3 COR WR] CR, FS, OHH, 0.2202 Lbs Y Control Area 2-New Haz Mat Locations UR2,WR3 ----------------------------'----'-------------------------------566 ·6131-90-4 S 100 Sodium Acetate Trihydrate [Acetic Acid Sodium Sal!Trihydrate][MP 324oC] IR 3.3113 Lbs Control Area 2-New Haz Mat Locations [RTECS# AJ4300010] [HR: H2] 567 26628-22-8 ,. S 100 Sodium Azide [Nondetonatable) [LD50-0ral:.27 mg/kg; LD50-Skin: 20 mg/kg] [MP HT, OHH, UR3, 0.2202 Lbs Y Control Area 2 -New Haz Mat Locations 275oC] [pH 9] [RTECS# VY8050000] [HR: H4 R3 WRj WR2, RMP-T3 568 144-55-8• L 10-25 Sodium Bicarbonate [Sodium Hydrogen Carbonate) [Calibrating Buffer] [NaHC03) NH 0.0264 Gins Control Area 2 -New Haz Mat Locations [pH: 10] [HR: OJ -------------------------------------------------------------~-- 569 144-55-8 S 100 Sodium Bicarbonat~ [Sodium Hydrogen Carbonate] [NaHC03] [HR: OJ NH 13:2379 Lbs Control Area 2-New Haz Ma.I Locations · 570 1070-89-9 S 100 Sodium bis(Trimelhylsllyl)Amlde [N-Sodiohexamethyldisitazane] [MP 171oC; FP CR, FS, WR2 0.0793 Lbs Y Control Area 2-New Haz Mat Locations 63oF) [Aldrich 235083] [HR: H3 F2 R2 COR] 571 16940-66-2 S 100 Sodium Borohydride [1-Sodium Tetrahydroborate] [Alkali) [LDLo-0: 160 mg/kg] CR, FS, TX, WR2 0.6057 Lbs Y Control Area 2 -New Haz Mat Locations [RTECS# ED3235000] [HR: H3 F2 R2 COR WR] 572 124-65-2 S 100 Sodium Cacodylate [Hydroxydlmethylarslne Oxide, Sodium Salt)[Cacodyllc Acid CA, OHH, RMP-T3 1.0463 Lbs Control Area.2 -New Haz Mat Locations Sodium Salt) [HR: H2) 573 497-19-8 S 100 Sodium Carbonate [Soda Ash)[Dlsodium Carbonate)[Carbonic Add, Dlsodlum Salt) IR 0.2202 Lbs Control Area 2 -New Haz Mat Locations .[Crystal Carbonate] [pH; 11.2] [l.050-0: 4,090 mg/kg) [RTECS# VZ4050000] [HR: H1) ------------'-------57 4 497-19-8• L </=50 Sodium Carbonate [Soda Ash)[Disodlum Carbonate)[Carbonlc Acid, Disodlum Salt] IR 0.7925 ~Ins Control Area 2 -New Haz Mat Locations [Crystol Carbonate] [Calibrating Buffer) [Na2C03] [pH: 6-10] [HR: 1-!1] 575 7647-14-5 S 100 Sodium Chloride (Salt] [Normal Saline] [Isotonic Salt] [LD50-0 >10"gm/kg) [MP IR 35.3600 Lbs Control Area 2-New Haz Mat Locations 801oC] [RTEeS# VZ4725000) [HR: H1) LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maxlmumltotal amount in use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10o/, In use at any time. Control Area 2: Entire building, excluding Chemical Waste StoragelRooms L114 &-L117. Existing Haz Mat Locations: Cold RoomlL 103, Magnet RoomlL 109, Mass Spectrometry LablL 11 O, Robotics LablL 101, RefrlgeratorlL 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip LabslL120, Glasswash LablL113, Open LablL107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALSIOCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES ING. -1111312001 -PAGE 39 - ·-·-, _ /j't--i,J.'.;;:· l,;?,'ffe-t-';'l':'-T. t'·"--. ·-··· ' -:. -1) _,, -· ---t..~ ~ cy·, ~ W@.!allllllla~a: "' •-~-__ ........... --.: .~ . .,,,., ~ ---. _i_:_:_ ... Isis Pharmaceuticals/Ibis Laboratory -1'891 Rutherford~ Carlsbad CA-Control Area 2llabs: Hazardous Materi;lls Inventory ---·~ :-,.;.,.'. '< .... ~·:-.~ :..~-· -----:;:-;~ ·... --.-------.. ---.--.! ~· ---; . : •.• ~·. ' Item?-.C~#··'.·-' ', State-CoriQ"/ •.. 1-Maierl!ll <·., ·· .. _ _. · · ·.·> ,> .-.: ·.· · .:: : · Hazard Class :.-. Storage Units Cabs LEV · Location .... ,,.... ' . _,·.-:;_·,_ .. , .. _. ~ -:. ·~· _·. --.. · ~ · .. _,_.-.·. -~. ---.·. ·-. . ' ~76 7647-14-5* L </=90 Sodium Chloride Yolumetrlc Stan<!ard [Normal Saline]Psotonlc Salt] [NACL][pH: 10-IR 0.2906 Gins Control Area 2 -New Haz Mat Locations 12][HR: H2] 577 25895-60~7· L 578 25895-60-7 s 579 4418-26-2 s 580 151-21-3 s 581 7681-49-4 s 582 7646-69-7 s 583 10034-88-5 s .584 1310-73-2* . L 585 1310-73-2 s 586 7681-82-5* L 587 7681-82-5 s 1-5:0M Sodium Cyanoborohydride [1.0M-5.0M Solution in Sodium Hydroxide or CR, FL 1B, OHH, Tetrahydrofuran] [FP-1oF; BP >200oF] [Aldrich 296813] [HR: H3F3 R1 CORWR) SN, TX, WR1 100 Sodium Cyanoborohydride [Sodium Cyanotrihydroborate] [MP >242oF; FP <212oF] CR, FS, HT, WR1 [LD50/LC50: No data avallble-rtsted as Highly·Toxlc-Aldrich 156159] [HR:H4 F2 R1 CORWR] 100 Sodium Dehydroacetic Acid (Dihydroacelic Acid Sodium Salt] [DHA Sodium Sall] [MP 109oC] [LD50-0: 500 mg/kg] [HR: H2] 100 Sodium Dodecyl Sulfate [Dodeqi Sulfate Sodium Salt] Sodium [Laury! Sodium Sulfate] [SOS) [MP 204oC) [LD50-0 1288 mg/kg) [Sigma l6026) [RTECS# WT1050000] [HR:'H1] 109 Sodium Fluoride [NaF] [LD50-0: 52 mg/kgJ [RTECS#WB0350000J [HR: H3J . 100 Sodium Hydride [MP 800oC] [RTECS# WB3910000) {HR: H3 F3 R2 COR WR] OHH,TX IR IR,OHH,TX 9R,FS,WR2 100 Sodium Hydrogen Sulfate Monohydrate [Sodium Blsulfal\! Monohydrate] [HR: H3 R1 CR, WR1 CORWR] </=50 Sodium Hydroxide [Caustic Soda) [Base] [</=27% in Water] [C 3350A, CR 33~B.~350C,3308B, Y, ZJ [MACuDlzer9?76J [MacDermld 19276) [Omnibond Plus 271] [DS-40) [PB484BJ [Enprep 114EJ [NALCO 2584] [LOSO-Oral @50%: 562 mg/kg) [pH: 12-14) [Base] [HR: H3 CORI >50 Sodium Hydroxide [Caustic Soda) [Base] [Lewis Red Devii Lye Drain Opener] [APC CR, TX, WR1 Caustic'Alkaline Cleaner] [APC 500 Heavy Duty Caustic Cleaner] [Cycle AL-100] [LD50-0ral: 140-280 mg/kg] [NAOHJ [HR: H3 R1 COR WR] 10 Sodium Iodide [Aqueous Solution -FP None] [LD50-O 4340 mg/kg] [RTECS# WB6475000] [HR: H2j 100 Sodium Iodide [LD50-O 4340 mg/kg] [RTECS# WB6475000] [HR: H2] IR;OHH,SN IR,OHH,SN 0.0264 Gins Y FLY Control Area 2 -New Haz Mat Locations 0.5000 Lbs y Control Area 2 -New Haz Mat locations 0.2202 Lbs Control Area 2 -New Haz Mat locations 4.9559 Lbs Control Area 2 -New Haz Mat Locations 0.2202 Lbs Control Area 2 -New Haz Mat locations 0.4405 Lbs y Control Area 2 -New Haz Mat Locations 1.1013 Lbs Control Area 2 -New Haz Mat Locations o.3170 Gins Control Area 2 -New Haz Mat Locations 5.7460 Lbs Control Area 2 -New Haz Mat Locations Q.0264 Gins Control Area 2 -New Haz Mat Locations 0.0550 Lbs Control Area 2 -New Haz Mat Locations 588 124-41-4* L </=50 Sodium Melhoxlde [</=50% Solution In Methanol) [Sodium Melhylate) [BP 64.6oC; CR, FL 1B, OHH, FP 50-60oF] [LEL 3.6; UEL 7.3] [SG 0.945; VD 1.1] [RTECS# PC3570000] [HR: H3 WR2 F3W2COR] 0.9000 Gins Y FLY · Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and Iii-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <101/o In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 · Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 • PAGE 40 - .. .-. ---; ____ ~~ ~~:~---.,.. . ·,---!-·' -"i-\' -! ---~ -~-·-.... ~ ~~ . _, . -~-------- Isis Ph~rmaceuticais/lbis Laboratory -1891 Rutherford, Carlsbad CA-Control Area 2/Labs: Hazard~us Materials Inventory .. ·:.1 -. ·. ·--.-·. ; .... ·. :.,,·.~·:·-· .... ~--:----:--· ,, . _': ____ -. ., ·<~-,.~.-~. -=-...... :. ·:, :-H~arcfolass·,: .' •Storage·· Units ·Cabs LEV Location ltem.-·CAS#:-:··J,_ ·: .. .Stiite,,:~.onc~ -~~terlaL··:,.-·~l: ·:·'=' :'. ·. ,''.. · ,: ... · ·.·, • -. . .•. , .... •. . . ~ . . ~ •. , .·, . 1:. . · .. ( •,l •• • •, •• • • • .... :: • • -~ • , • .• .... , 589 124-41-4 s 100 Sodium Methoxlde [Melrn!nol Sodium Salt] [Sodium Melhylate] [MP >300o; FP 50oF] CR, FS,. WR3 0.1101 Lbs y Control Area 2 • New Haz Mat Locations [RTECS# PC3570000] [HR: H3 F2 R3 COR WR] -·------~ ---- 590 10102-40-6, s 100 Sodium Molybdate{VI) Dihydrate [RTECS# QA5075000] [HR: H2] IR 0.2202 Lbs Control Area 2 -New Haz Mat Locations 591 7632-00-0 s 91 Sodium Nitrite [l050-0: 186 mg/kg] [RTECS# RA 1225000] [HR: H3 COR OX] · CR,OX1, TX 2.2100 Lbs Control Area 2 -New Haz Mat Locations 592 10332-33-9 s 100 Sodium Perborate Monohydrate [RTECS# SC7320000] [HR: H2 R1 ,OX WR] IR,OX1,WR1 0.2202 Lbs Control Area 2 -New Haz Mat Locations 593 7558-80-7 s 100 Sodium Phosphate Monobaslc [Sodium Dihydrogen Phosphate] [LD50-0 7100 IR 3.3040 Lbs Control Area 2-New Haz Mat Locations mg/kg] [RTECS# WA 1900000] [HR: H1] 594 7757-82-6 s 100 Sodium Sulfate (pH: 5.2-9.5] [MP 884oC] [LD50-0 5989 mg/kg] [RTECS# IR 15.0000 Lbs Control Area 2 -New Haz Mat Locations WE1650000][HR: H1] 595 7727-73-3 s 100 Sodium Sulfate Decahydrate [Glaubefs Salt] [HR: H2) IR 1.1013 Lbs Control Area 2 -New Haz Mat Locations 596 1313:.8~-4 s 100 Sodium Sulfide Nonahydrate (RTECS# WE1925000] [HR: H3 F2 CORJ CR,FS,OHH 0.2202 Lbs Control Area 2 -New.Haz Mat Locations 597 7757-83-7 s 100 Sodium Sulfite [LD50-0: >2,825 mg/kg) [RTECS# WE2150000J (HR: H1] IR 8.8400 Lbs Control Area 2 -New Haz Mat Locations 598 1303-96-4 s 100 Sodium Tetraborate Decahydrate [Sodium Borate! [Borax] [Sodium Tetraborate IR 1.1013 Lbs . Coiltrol Area 2 -New Haz Mat Locations · PentahydrateJ [RTECS# VZ2275000] [HR: H2J ---··--·--- 599 865-48-5 ·s 100 Sodium-t-Butoxide [Aldrich 359270] [HR, H3 F2 COR] CR,F.S 1.1013 Lbs Control Area 2. -New Haz Mat Locations 600 21736-83-4 s 100 Spectinomycin Hydrchoride (LD50-0ral: >5 g/kgJ [HR: H1] IR 0.0132 Lbs Control Area 2 -New Haz Mat Locations 601 124-20-9 s 100 Sperrpidh\e [N-(3-Aminoprilpyl)-1,4-Butanediamine] [1,5, 10-Triazadecane] [MP CR 5.5056 Lbs Control Area 2 -New Haz Mat Locations . 22oC; FP >230oF] [RTECS# SJ7000000l[HR; H3 COR) 602 306-67-2 s 100 Spermlne Tetrahydrochloride [pH: 5-7) iSigma S2876] [HR: H1] IR 0.0220 Lbs Control Area 2 -New Haz Mat Locations 603 3810-74-0 s 100 Streptomycin Sulfate (Sigma S6501] [HR: H2] OHH,SN,P65 0.0550 Lbs Control Area 2'-New Haz Mat Locations 604 10027-07-3 L 100 Suberoyl Chloride [Suberic Acid Dichloride] (BP 162oC/15mm; FP >230oFJ [Aldrich CL3B, CR, SN, 0.2202 Gins Control Area 2 -New Haz Mat Locations 235547] [HR: H3 F1 R1 COR WR1J WR1 605 57-50-1 s 100 Sucrose [a-D-Glycopyranosyl b-0-Fructofuranoslde] [Saccharose) [Cane Sugar) NH 2.2100 Lbs Control Area 2 -New Haz Mat Locations [Electrophoresis Reagent] [HR: OJ LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustlble Liquid Vapor. FLV-Flammable Liquid Vapor. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% In use at any time. Control Al:'ea 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locatio_ns: Cold Room/L103, Magnet Room/L109, Mass Spectrometry Lab/L110, Robotics Lab/L101, Refrlgerator/L103 New Haz Mat Locations: BSL-2 Labs/L115and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 · Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. • 11/13/2001 • PAGE 41 - _, --··-J.!,,-r-·---Vi*?-·,;,·-.·· ···-· -·-···• 1111111111111?' C ~ ~ ',:jf_:.::.: ~....::i .. ...:"'•'"':: __ .___.; __ ___. ,.,_..J ma:: __ ;-·-.. ·--····-. . . . Isis Pharmaceuticals/Ibis Lab9ratory-1891 Rutherford, Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory tte~f ~~#~.> · _::_·(''--~iat~·:_-;-po~~{'M~ter1,1 .: ... :f ::· · . : ------.-------.. ..... .::-. · H~rd Class · ·: : . Storage_ ;:_U1Jits · Cabs . LEV Location ,··:::'. · .. ::-. '. 606 26412-87-3 s. 100 Sulfur Trioxide Pyridine Complex [Pyridine Sulfur Trioxide] [MP 155oC] [Aklrich IR, OHH, OX1, 0.4946 Lbs Control Area 2 • New Haz Mat Locations S7556 -listed as a powder/solid] [HR: H2 R1 OX] WR1 ------------- 607 7564.93.9-L >/=67 Sulfuric Acld[Unhealed-Storage or Use-Closed Conditions] [H2SO4] [Acid] [LC50-CR,TX,WR1, 14.4183 Gins y Control Area 2 -New Haz Mat Locations Inhalation: 254 ppm] [LOSO-Oral: 2,140 mg/kg] [DOT Class 8yPG II) [HR: H3 R1 RMP-T3 CORWR] 608 110-18-9 !-100 TEMED [N,N,N',N'-TelramelhylelhylenediamlneJ [BP 120oC; FP 50oF] [LEL 0.98; CR,FL1B 0.0110 Gins y FLV Control Area 2 • New Haz Mat Locations UEL 9.08l[SG 0.77; VD 4.022] [RTECS# KV7175000J [HR: H3 F3 CORI 609 429-41-4• L </=75 Tetrabutylammonlum Fluoride [1.0M Solution in Tetrahydrofuran or,Water] [FP 1oF; FL1B, IR, OHH, SN 0.6605 Gins y FLV Control ·Area ·2 • New Haz Mat Locations BP >100oFJ [Aldrich 216143, 361399, 331953, 358673] [HR: H3 F3] 610 429-41-4 s </=50 Tetrabutylammonlum Fluoride [TBAF] [on Alumlnal[Aldrich 331953] [HR: H? F1] FS,IR,OHH· 0.5000. Lbs Control Area 2 -New Haz Mat Locations 611 22206-57-1 s 100 Telrabutylammonlum Fluoride Hydrate [MP 62oC] [Aldrich 241512] [HR: H2] IR 1.7621 Lbs Control Area 2 • New Haz Mat Locations ·--------- 612 118-75-2 s 100 Telrachloro-1,4-Benzoquinone [Chlqranli] [2,3,5,6-Telrachloro-~Benzoquinone] [MP IR, OHH 0.0550 Lbs Control'Area 2 • New Haz Mat Locations 2890] [Aldrich 232017] [HR: H2] 613 9004-76-6 s 100 Tetraglycol [Glycofural) [fetrahydrofurfuryl Acoohol Polyelhyelenglycol Elh!!r] [HR: IR,OHH 0.2202 Lbs Control Area 2 • New Haz Mat locations H1] 614 109-99-9 L 100 Tetrahydrofuran [FP 1oF; BP 69i>C] [LEL 1.8; UEL 11.8] [SG 0.869; VD 2.5] [LD50-O FL 1B,JR, OHH, SN 14.0000 Gins y FLV Control Area 2. New Haz Mat Locations 1650g/kg; LC50 21;000 ppm] [RTECS# LU5950000] [HR: H2 F3] • 615 14221-01-3,· s 100 Tetrakis(triphylphosphine)palladium(O).[Aldrich 216666] [HR: H1] )R 0.0110 Lbs Control Area 2 • New Haz Mat Locations ·---·-·· .. 616 80-70-6 L 100 Tetramelhyl Guanidine (1,1,3,3-) [BP 52oy; FP 140oF] [HR: H3 F2 COR] CL3A,CR 0.0264 Gins CLV Control Area 2 • New Haz Mat-Locations 617 58-55-9 s 100 Theophylllne [SLO] [MP 271oC] [LD50-0 225 mg/kg) [RTECS# XH3850000] (Sigma IR, OHH, TX 0.1101 Lbs Control Area 2 . New Haz Mat l!)Catlor\s T-1633 et al) [HR: H2] 618 67-03.:S s 100 , Thiamine Hydrochloride [Vitamin B1. Hydrochloride] [Aneurine] [MP 248oC] [RTECS# IR 0.2312 Lbs Control Area 2 -New Haz Mat Locations X1735000] [H/t H1) 619 2227-79-4 s 100 Thlobenzamide [MP 116oC] [RTECS# CV5860000] [Aldrich 148229 • Toxic by IR,TX 0.0550 Lbs Control Area 2 • New Haz Mat Locations inhalation • no LC/LD50 data available] [HR: H3] 620 1918-77-0 s 100 ThiopheneaceticAcid (2·) [MP 63oCJ[HR: H2 COR] CR 0.0110 Lbs Control Area 2 -New Haz Mat Locations ---·-····--- LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLV-Flantmable Liquid Vapor. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10o/. In use at any time. Control Area 2: Entire building, excluding·Chemlcal Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 11 O, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No u~e, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyroptforlcs: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. • 11/13/2001 • PAGE 42 - ··.,.· ·~·· .... - ' ·-.. t:--~-o/~:· ·-I ~~-:(; ;:·:.~, .... :_· r· .... ~ .. . ... ~. •. -:'..,,,.,;.. ;,,y ~ -·-,. ::all ·-------- Isis Pharmaceuticals/Ibis Laboratory -1891 Rutherford, Carlsbad CA -Control Area 2/Labs: Hazardous Materials Inventory lte~·. CAS# ·.::-,.:: S~te tco~~ .: ~at~lal .. '/;: ·_:,.f; .\: ·,,,: · .:-; . ..._: .. 1'• •• Calis LEV :Hiszard Class· S~orage Units Loca,tlon . . . 621 39098-97-0 L 100 Thlopheneacetyl Chloride (2-) (Bf' 130oC/90mm; FP 215oF] [Aldrich 295995) [HR: CL3B, CR, WR1 0:0110 Gins Control Area 2 -New Haz Mat Loca!ions H3 F1 R1 COR WR) ---·---· ·-------·-______ ,., -- 622 5271-67-0 L 1QO Thlophenecarbonyl Chloride (2-) (BP 206oC; FP 19!i<JF) [Aldrich 288985) [HR: H3 F2 CL3A, CR,WR1 R1 CORI - 0.0026 Gins CLV Control Area 2 -New Haz Mat Locations ·----·--·----~------ 623 30433-91-1 L 100 Thlopheneethylamine (2-) (BP 200oC; FP 190oF) [Aldrich 423270) [HR: H2 F2) CL3A,IR 0.0220 Gins CLV Control Area 2 -New Haz Mat Locations 624 108-98,5 L 100 Thlophenol (Benzenethlol) [Phenol Mercaptan) [LC50: 66·ppm; LD50-S: 300 mg/kg; CL2, HT, JR, SN, 0.0025 Gins y CLV Control Area 2 -New Haz Mat Locations LDS()-0: 46 mg/kg) [MP-15oC; BP 169oC: FP 123oF) [RTECS# DC0525000) [HR: UR1 H4F2R1] 625 463-71-8 L 100 Thlophosgene [Carbon.Chlorosulfide] {BP 730; FP None] [LD50-0: 020 mg/kg) CR,WR2 0.0066 Gins y Control Area 2 -New Haz Mat Locations [RTECS# XN29300000) [HR: H3 R2 COR WR) ------ 626 13~3-4Q-2 s 100 Thlostrepton [Peptide Antibiotic) [HR: H1] OHH 0.5617 Lbs Control Area 2 -New Haz-Mat Locations ----------- 627 62-56-6 s 100 Thlourea psothlourea]'[MP 1740) [LD50-O: 1~5 mg/kg) [RTECS# YU2800000) [HR: CA, JR, OHH, SN, 0.2202 Lbs Control Area 2 -New Haz Mat Locations· H3) -TX,P65 628 7772-99-8 s 100 Tin(ll).Chlorlde [Stannous Chloride II) [MP 246oC; BP 605oC; FP None) [RTECS# CR 1.1013 Lbs Control Area 2 -New Haz Mat Locations XP8700000) [HR: H3 COR)' 629 10025-69-1 s 100 Tin(ll).Chlorkle Dihydrcite [Stannous Chloride) [MP >37oC; BP 652oC] [LD50-0 700 CR,OHH,SN, 0.0550 Lbs Control Area 2 -New Haz Mat Locations mg/kg) [RTECS# XP8850000] [HR: H3 R1 COR WR] WR1 630 7646-78-8 L 100 Tin(IV) Chloride [Tin Tetrachloride) [Stannic Chloride) [MP -33oC; BP 114oC; FP CR,TX,WR1 -0.0264 Gins Control Area 2 -New Haz ~at Locations None; MN 260.49) [tC50: 215 ppm) [RTECS# XP8750000) [HR: H3 R1 COR WR) 631 7550-45-0 L 100 Titanium(IV) Chloride [Titanium Tetrachloride] [TICl4) [MW: 189.7) [MP -240; BP CR,H,:,OHH, 0.0264 Gins y ,Control Area 2 -New Haz Mat Locations 136.4oC; FP None] [LD50-O 464 mg/kg; LC50: 0.9 ppm) [RTECS# XR1925000) WR2, RMP-T1, [HR: H4 R2 COR WR] RMP-T3 632 108-88-3 L 100 Toluene [Permountl[MP ~93o; BP 110oC; FP 40oF] [LEL: 1.2; UEL: 7.1) [VD: 3.188; FL1B, IR, OHH, SG 0.867; VP: 28.53] [LD50-0; 5,000 mg/kg) [FV per Gin: 1250] [RTECS# P65 5.0193 Gins y FLV Control Area 2 -New Haz Mat Locations XS5250000) [HR: H2 F3) 633 6192-52-5 s 100 Toluenesulfonic Acid Monohydrate (p-) [MP 103oC) [LD50-O 2480 mg/kg) [RTECS# CA, CR, OHH 1.1013 Lbs Control Area 2 -New Haz Mat Locations XT6300000] [HR: H3 COR OX) LEV: Local or general/area exhaust yentllation required for Class I, II and Ill-A Liquids use-open conditions. <;LY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10'/e In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L103, Magnet Room/L109, Mass Spectrometry Lab/L110, Robotics Lab/L101, Refrigerator/L103 New Haz Mat'Locatlons: BSL-2 Labs/L 115 and L 116, Equip Labs/L 120, Glasswash Lab/L 113, Open Lab/L 107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 43 - -! -.. ·----~--,.,, :1 .•. ,.-,-... --..---:-,a·'J.--: '· ·-----· .. '·-· · ·; -'{;, --• {9;.,:· <~-~~ . "'"C: • ,.,__! __ ".,_; -.. ~,, ~ ... ~ -i ,_ --------- Isis Pharmaceuticals/Ibis Laboratory-1891 Rutherford, Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory Item ,CASf:·/J:,_;·,sta,ie-'_.-~o~r:.}.,~t•rat:,-;\{_-::_ y, ·,:-·· · .. ·") :' : .. :.:-!·_-i-Ha~rdClass. 634 98-59-9 S . 100 Tolue~ulfonyl Chloride (p-) [Tosyl Chloride] (MP 69oCJ [Aldrich 240877] [HR: H3 CR COR] . 635 455-16-3 s 636 4083-64-1 L 637 99-04-7 s 638 87 4-60-2 L 639' 622-58-2 L 640 1004-38-2 s 641 396-01--0 s 642 288-88-0 s 643 75-80-9 s 644 102-82-9 -· L 645 76-03-9 s 646 76-03-9* L 647 102-71-6 L 100 Toluenesulfonyl Fluoride (p-) [Phenylmethylsulfonylflu_oride] [PMSF [BP 41oC; BP CR, WR1 112oC/16mm; FP 2220FJ [RTECS# XT8050000]1 [HR: H3 R1 COR] 100 Toluenesulfonyl Isocyanate (p-) [Tosyt lsocyanatei [BP 144oC; FP >230oF] [l.D50-O CL3B, IR, OHH, 2234 mg/kg; LC50 >640 ppm] [Aldrich 189278} [RTECS# DB9032000J [HR: H2 F1 SN, TX, WR1 R1] 100 ToluicAcid (m-) [MP 1080] [l.D50-0: 400 mg/kg] [RTECS#XU1200000] [HR: H2] IR, TX 100 Toluoyt Chloride (p-) [MP -2oC; BP 225oC; FP 180oF] [8TECS# XV1660000J [HR: CL3A, CR H3F2COR] 100 Tolyt Isocyanate (p-) [Methylphenyt Isocyanate] [BP 70oC/12mm; FP 150oFJ [Aldrich CL3A, CR, SN, 143634} [HR: H3 F2 R1 CORI WR1 100 Triaminopyrimldine(2,4,6-) [MP 249oC] [Aldrich T45802] [HR: H2] IR 100 Triamterene [2,4,7-Triamlno-6-Phenylpteridine] [Urocaudal] [LD50-O: 400 mg/kg] OHH, TX [RTECS UO3470000] [HR: H3] 100 Triazole (1,2,4-) [MP 119oC] [RTECS# XZ3806000][HR: H2) IR 100 Tri~romoethanol (2,2,2-) [MP 73oC] [RTECS# KM3675000) [HR: H2J IR 100 Tributylamin(l [n-butylamlneJ [MP -70o; BP 2160; FP 146oF] [LEt: 1.4; UEL 6] [l.D50-CL3A, CR, OHH, O: 114 mg/kg) [RTECS# YA0350000) [HR: H3 F2 R1 COR WR) TX, WR1 100 TrichloroacetlcAcld [LD50-O: 400 mg/kg] [MP 54oC; FP >230oFJ [RTECS# AJ7875000] [HR: H3 CORI CR,TX </=50 Triqhloroacetic Acid Solution [Deblock Solution] [TCA] [BP 197oF; FP None] [l.D50-CR 0: 800 mg/kg) [RTECS# AJ7875000] [HR: H3 COR) 100 Triethanolamlne [2,2,2-Nitrotriethanol] [Nitrilotriethanol] [TEA] [BP 1900; FP 365oF] CL3B, IR, OHH [RTECS# KL9275000] [HR: H2 F1) Storage Units Cabs 1,.EV Location 0.2202 Lbs Control Area 2 -New Ha_z Mat Locatiiins ---------------. ~-----·-- 0.0220 L!>s Control Area 2 -New Haz Mat Locations 0.0~20 Gins Control Area 2 -New Haz Mat Locations 0.0220 Lbs Control Area 2 -New Haz Mat locations 0.0264 Gins CLV Control Area 2 -New Haz Mat Locations 0.0550 Gins CL V Control Area 2 -New Haz Mat Location~ Q.0550 Lbs Control Area 2 -New Haz Mat Locations 0.0220 Lbs Control Area 2 -New Haz Mat Locations 0.0550 · Lbs Control Area 2 -New Haz Mat Locations 0.4405 Lbs Control Area 2 -New Haz Mat Locations 0.0661 Gins CLV Control Area 2 -New Haz Ml!! Locations 6.8502 Lbs Control Area 2 -New Haz Mat Locations 3.7011 Gins Control Area 2 -New Haz Mat Locations 0.1101 Gins Conlrol Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% in use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L 114 & L 117. . Existing Haz Mat Locations: Cold Room/L 103, 'Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrlgerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrop!Torics: Storage and use-closed system conditions only. Building is protected thro_ughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 44 - _, -... (_-=lli·-"-• ~-:,±";£,: JI ~--------.-'-~~-~,_;,: -r: IIIL .. -.:--·-:.:- Isis Pharmaceuticals/Ibis Laboratoq -1891 Rutherford, Carlsbad CA -Control Area 2/Labs: Hazardous Materials Inventory ltem~CAS#·,' .. ,·.::._-state:'conc%-Mat,rlal \.. :·.· .-'Ha~rdCla~~--Storage· Units Cabs LEV Location ,,._' '··-··-· .. ····....:c_• • 648 122-51-0 L . 100 Triethoxymethane ITrielhyl Orthoformate] [Ethyl Orthoformate] [BP 146oC; FP 86oF] FL1C, IR, WR1 0.0220 Gins Y FLV Control Area 2 -New Haz Mat Locations [SG 0.891; VP 5.11) [LD50-0 7060 mg/kg;LD50-S 20 mi/kg] [RTECS# ~M6475000] · 649 121-44-8 L 650 73602-61-6 ,. L 651 97-94-9 L 652 554-70-1 L 653 617-86-7 L 654 76-05-1 L 655 407-25-0 L 656 75-89-8. . L. 657 1493-13-6 L 658 6485-79-6 L 659 13154-24-0 L 660 24313-88-0 s 661 4521-61-3 -s [HR: H2 F3 R1] . 100 Triethylamine [Dlethylaminoethane) ITEA][BP 88.8oC; MP -1150; FP 20oF] [LEL FL 1B,:IR, OHH; TX 1.2; UE~ 8] [SG 0.726; VD 3.5] [LD50-0: 450 mg/kg) [RTECS# YE0175000) [HR: H3 F3) 100 Trlelhylamine Trihydrofluoride [BP 70oC/15mm: FP 190oFJ [Aldrich 344648] [HR: H3 CL3A, CR F2-COR] 100 Trielhylborane ITriethylborlne] [MP -93o; BP 95o] [LD50-0: 23g mg/kg; LC50: 1,440 PY, TX, WR2 ppm] [RTECS# ED2100000] [HR: H3 F3 R2 WR] 100 Triethylphosphlne.[BP 127oC; FP 1oFJ [RTECS# S23400000] [HR: H3 F3 COR] CR,OHH,PY 100 Trielhylsilane [BP 107oC; FP 25oF; SG 0.728] [Aldrich 230197] [HR: F3 H2 R1] FL1B, IR, WR1 100 TrifluoroaceticAcid [VP: 107 mm@25oC)[SG: 1.48)[MW: 114.03)[8P72.4oC; MP~ CR, TX 15.40; FP None] [LC50-lnhalation: 214.4 ppm] [RTECS# AJ9625000) [HR: H3 CORJ 100 TrifluoroaceticAnhydride [HR; H3 R1 COR WR1] [FP None; MP·-65oC] [VP: 6.28 psi CR, WR2 @20oC] [Aldrich 106232] [HR: H3 R2 COR] 100 Trifluoroelhanol (2,2,2-) [MP -43.5oC; BP noe; FP 85oFJ [LEL 5.5; UEL 42) (SG CR, FL 1C, TX 1.391; VD 3.5) [LD50-0: 240 mg/kg; [050-S: 1680 mg/kg) [RTE(;$# l<M5250000] [HR: H3 F3 CORJ 100 Trifluoromethanesulfcinic Acid ITrifllcAcfd) [BP 162oC; FP None] [HR: H3 R1 COR CR, WR1 WR] 100 Trilsopropylsllane [BP 84-86oC; FP 99oF; SG 0.773] [Aklrlch 233781] [HR: H2 F3) FL 1C, IR 100 Trilsopropylsilyl Chloride [Chlorotriisopropylsllane) [BP 198oC; FP 145oF) [HR: F2 CL3A, CR, WR1 H3R1 COR) 100 Trimelhoxyaniline (3,4;5-) [MP 11 Oo] [HR: H2] IR 100 Trimelhoxybenzoyl Chloride (3,4.5-) [MP 81oC] [HR: H3 CORJ CR 4:2051 Gins Y FLV Control Area 2 -New Haz Mat Locations 0.0550 Gins ·CLV Control Area 2 -New Haz Mat Locations 0.0264 Gins ·y . Control Area 2 -New Haz Mat Locations 0.0132 Gins y Control Area 2 -New Haz Mat Locations 0.2642 Gins Y FLV Control Area 2 -New Haz Mat Locations 24.7553 Gins Control Area,2 -New Haz Mat Locations 0.0315 Gins y Control Area 2 • New Haz Mat Loc;3llons 0'.1321 Gins Y FLV Control Area.2 -New Haz Mat locations 0.0550 Gins Control Area 2 -New Haz Mat Locations 0.4405 Gins Y FLV Control Area 2 -New Haz Mat Locations 0.1101 Gins CLV Control Area 2 -New Haz Mat Locations 0.0220 Lbs Control Area 2 -New Haz Mat Locafions 0.1652 Lbs Control Area 2 -New Haz Mat Locations LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10% in use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry tab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorics: Storage and use-closed system conditions only. Building Is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001 -PAGE 45 - -, .. t-, __ , .. ti,, ~ t~ ~:~;.· /;' ->~----J ,,, .. r ·._ ... ___ j __ _:__: -.. ~: ~ -~ _,_ . . -·: __ ··c--·--·-- <' Isis Pharmaceuticals/Ibis Laboratory-1891 ~utherford, Carlsbad CA-Control Area 2/Labs: Hazardous Materials Inventory · item·:·:c~#;:,·;.:-./;:i\S.tat~':'.-c~~~~ ·.;_~~ti!_~!~-\?::·:'··_)\~-·._'.-_/<::):,·?;'":::. :_:.': ·. · : :-.° .. -· . ·=_-·· .. ·.·_.::_Haza~ ci.~s . .' .. Sto_rage_ Units : Cabs LEV Location 662 75-24-1 .L-97 Trlmelhyl Aluminum [HM] [MP 15oF; BP 125oC; FP -1 oF] [Nondetonable] [RTEC~ IR, PY, UR3,WR3 0.2642 Gins y Control Area 2 -New Haz Mat Locations BD2204000] [Aldrich 257222] [HR: H2 F3 R3 WR] 663 149-73-5 L 100 Trimelhyl Orthofonnate [BP 101oC; FP 60oF] [LEL 1.4; UEL 5.1] [SG 0.969; VD FL1B, IR,OHH, 1.5925 Gins y FLV Coittrol Area 2 -New Haz M(lt Locations 3.67] [RTECS# RM6650000J[HR: H2 F3 R1] . . WR1 -·-·------~---- 664 5927-18-4 L 100. Trimethyi Phosphonoacetate [BP 118oC/0.85mm; FP >230oF) (Aldrich 179758) [HR: CL3B, IR 0.0220 Gins . Control Area 2 -New Haz Mat Locations H2_F1] ---- 665 3282-30-2 L 100 . Trlmelhylacetyl Chloride [Pivaloyl Chloride] [BP 105oC; FP 48oF [SG 0.979; VD 4.2] GR, FL 18, TX, 0.2642 Gins y FLV Control Area·2 -New Haz Mat Locations [LC50 2.5 mg/I..] [RTECS# AO7200000] [HR: H3 F3 R1 COR] ·wR1 666 16898°52-5 s 100 Trimethyleneplperidlne (4,4'-) [MP 65oF] [Aldrich 121207] [HR: H2] IR 0.2202 Lbs Control Area 2 -New Haz Mat Locations 667 108-75-8 L 100 Trimelhylpyridine (2,4,6-) [Colidlne] [BP 1710; FP 135oF] [LD50-0 400 mg/kg] CL2,IR,TX 0.4782 Gins CLV Control Area 2 -New Haz Mat Locations [RTECS# l,.IU0970000] [HR: H2 F2J 668 2916-68-9 L 100 Trimelhylsilyl Ethanol (2-) [2-(Trimethylsilyl)Elhanoij [BP 71oC; FP 123oF) [RTECS# Cl2, IR 0.1101 Gins CLV Control Area 2 -New Haz. Mat Locations KM5480000J [HR: F2 H2J ·669 27607-77-8 L 100 Trimethylsily!Trilluoromethanesulfonate [TMS Triflate] [BP 77oC; FP 78oFJ LSG CR, FL 1C, WR2 0.0220 !31ns y FLV Control Area 2 -New Haz Mat Locations 1.228] [Aldrich 225649] [HR: H3 f3 R2COR WR) 670 18107-18-1 L </=p() Trlnielhylsilyldiazomethane [2.0M Solution in Diethyl Ether or Hexanes) [FP >/= -FL 1A, IR, OHH 0.5284 Gins y FLV Control Area 2 -New Haz Mat Locations 31oF; SG 0.773] [Aldrich 362832] [HR: H1F4] 671 18156-74-6-L 100 TrilllE!lhylsilyllmidazole (1-) [BP 93oC; FP 42oF] [SG 0.956] [RTECS# Nl8700000] FL1B, IR, OHH, 0.0008 Gins y FLV Control Area-2 -.New Haz Mat Locations [HR: F3 H2 R1] WR1 672 76-83-5 s 100 Triphenylmet(lyl Chloride.[Chlorotriphenylmethane] [Trityl Chloride] [MP 110oC] CR 0.2202 Lbs Control Area 2 -New Haz Mat Locations [Aldrich T83801][HR: H3 COR) 673 603-35-0 s 100 Triphenylphosphine [MP 790; FP >359oF) [RTECS# S23500000] [HR: H2) l~,SN 0.6608 Lbs Control Area 2 -New Haz Mat Locations 674 32315-10-9 s 100 Triphosgene [bis(Trichloromethyi) Carbonate] [MP 79qC; BP 203oC] [Aldrich IR,WR1 0.2202 Lbs Control Area 2 -New Haz Mat Locations 330752] [HR: H2 R1 WR] 675 102-69-2 L 100 Trlpropylamine [BP 175oC; FP 90oF} [LFL 0.7; UFL 5.6] [SG 0.753; VD 4.9] [LD50-0 FL 1C, IR, TX, WR1 0.0053 Gins y FLV Control Area 2 -New Haz Mat Locations 96 mg/kg; LC 50 >5100 ppm) [RTECS# TS1575000] [HR: H2 F3 R1] LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount In use and storage, unless otherwise noted. Not all materials are In use at the same time, with <10% In use at any time. Control· Area 2: Entire building, excluding Chemical-Waste Storage/Rooms L 114 & L 117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 Combustible Dusts: No use, manufacture or generation of dusts in such a manner that concentrations and conditions create a fire or explosion potential. Pyroph·orics: Storage and use-closed system conditions only. Building is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-ERIKSEN-RATTAN ASSOCIATES INC. -11/13/2001-PAGE 46 - ·/ ·:--~- •, '•• -·· -... i.:-.. ~,5-}--~ ~:ii "'' ·-·-l --:'0 ....... , .. --·-l ~_;_:.. , .. -.,:...,1-~ lalllll---........... -Isis Pharm~c9uticals/lbis Laboratory -1891 Rutherford, Carlsbad CA-Control Area 2/Labs: Hazardol!s Materials Inventory -m~m ::.c~\'./(:\ s~fi}c~nc~\~~~i~~" .it;fr(;.:~:::.~~{: /'r}i?>}' :>.: .. ,_.._:·: ,._ ·• _;: • ·'.'-\1.~Hazari:lci~s ··· : Storage: Units·· Cabs· LEV . Location· , • ,• I ', ~ • ,' • '' • • • ~ ', " • " ' ' • .. ,: • ' ' ' ' • ' 676 4097-89-6 L 100 Tris(2-Amln(?elhyl) Amine [2,2' ,2'-Trlelhanolamine} [BP 114oC/15mm; FP >230oFJ CL3B, CR, HT, 0.0011 Gins y Control Area 2 -New Haz Mat Locations [LD50-0 246 mg/kg; LC50 117 ppm} [SG 0.977; VD 5} [RTECS# KH8587082J OHH [Aldrich 225630] [HR: H4 F1 <;:OR] 677 52409-22-0 s 100 Tris(Dibenzylideneacetone)Dipalladium(0).[MP 152oC) (Aldrich 318774] [HR: H1] IR 0.0044 Lbs Control Area 2 -New Haz Mat Locations 678 9002-93-1 L 100 Triton X-1 OO/S-114 [Octylphenoxypolyelhanol) [Octoxynol 40) [FP >550oF) [pH: 6-8) CL38,IR 0:1101 Gins Control Area 2 -New Haz Mat Locations [LD50-0: 1,800 mg/kg] [HR: H2 F1 I 679 6850-28-8 s 100 Trizma Acetate [Tris(Hydroxymethyl)Aminomelhane Acetate) [Tris-Acetate-EDTA IR 0.4405 Lbs Control Area 2 -New Haz Mat Locations Buffer} [TAE Buffer [Sigma T2158) [HR: H1] 680 77-86-1 s 100 Trizma Base [THAM] [Tris(Hydroxynielhyi)Aminomelhane} [2-Amino-2-IR 1.5418 Lbs Control Area 2 -New Haz Mat Locations (Hydroxymelhyl)-1,3.Propanediol] [TRIS) [Tromelhane) [Sigma 7-9] [MP 171 oC; BP 219oC/10mm;_FP None] [RTECS# TY2900000] [HR: H1) 681 1185-53-1 s 100 Trizma Hydrochloride [Tris(Hydroxymelhy1) Aminomethane Hydrochloride) [TRIS-IR 1.6520 Lbs Control Area 2 -New Haz Mat Locations HCL) [Tris Hydrochloiide] [Sigma T2413 et aq [No LC/LD 50 data available] [HR: H2) 682 61-54-1 s 100 Tryplamine [3-(2-Aminoethyl)lndole] [MP 114oC] [RTECS# NML4020000) [HR: H1] IR,OHH 0.1101 Lbs Control Area 2 -New Haz Mat Locations 683 79586-22-4 s 100 Ubiqul!in [UB) [ATP-Dependent Proteolytic Factor} [Sigma U6253) [HR: H1] IR 0.OQ55 Lbs Control Area 2 -New Haz Mat Locations 684 58-96-8 s 100 Uridin13 [Uracil-1-b-D-ribofuranoside} [1-bela-D-Ribofuranosyiuracll] [MP 166oC) JR 1.9824 Lbs J Control Area 2 -New Haz Mat Locations [RTECS# YR1450000) [HR: H1] 685 2156-04-9 s 100 VinylphenylboronicAcid (4-) [MP 190oC] [Aldrich 417580] [HR: H1] IR 0.0771 Lbs Control Are!l 2 -. New Haz Mat Locations 686 1477-55-0 L 100 XyleneDiamine (p-)"[m-Xylene-a,a'-Dlamlne) [BP 265ol745mm; FP >230oF] CL3B,CR 0.0044 Gins Control Area 2 -New.Haz Mat Locations [RTECS# PF8970000J [HR: H3 F2 CORJ 687 557-34-6 s 100 Zinc Acetate [Acetic Acid Zinc Salt] [1;D50-O 2510 mg/kg] {RT~CS# AK1500000] IR;OHH 1.1013 Lbs Control Area 2 -New Haz Mat Locations [HR:H1J 688 7646-85-7 .. L 10 Zinc Chloride pn Diethyl Ether or Tetrahydrofuran] [FP -40oF lo -4oF] [LD50-0 350 CR, FL 1A, OHH, 0.0582 Gins y FLV Control Area 2 -New Haz Mat Locations mg/kg} [Aldrich 276839, 366374] [RTECS# ZH1400000J[HR: H3 F3 CORJ TX LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLY-Combustible Liquid Vapor. FLY-Flammable Liquid Vapor. Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Not all materials are in use at the same time, with <10%·In use at any time. Control Area 2: Entire building, excluding Chemical Waste Storage/Rooms L114 & L117. Existing Haz Mat Locations: Cold Room/L 103, Magnet Room/L 109, Mass Spectrometry Lab/L 110, Robotics Lab/L 101, Refrigerator/L 103 New Haz Mat Locations: BSL-2 Labs/L115 and L116, Equip Labs/L120, Glasswash Lab/L113, Open Lab/L107 CombustlbJe Dusts: No use, manufacture or generation of dusts In such a manner that concentrations and conditions create a fire or explosion potential. Pyrophorlcs: Storage and use-closed system conditions only. Building is protected throughout by an automatic fire sprinkler system. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -ERIKSEN-RATTAN ASSOCIATES INC. • 11/13/2001 -PAGE 47 -· I I I I I I I I I I I ·1 I I I I I 1· I ISIS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT ATTACHMENT 1-C -DEFINITIONS FOR ABBREVIATIONS HAZARDOUS MATERIALS INVENTORY ANALYSIS 25 September 2001 Prepared by ..-Eriksen-Rattan Associates Inc. 4719 Palm Avenue La Mesa, California Telephone 619.466.6285 FAX 619.466.6233 _EMAIL MaryRattan@thecoderesource.com or MaryRattan@covad.net I I j 1· I I I i I I I DEFINITIONS FOR ABBREVIATIONS HAZARDOUS MATERIALS INVENTORY ANALYSIS A: Aerosols • AL 1 -Aerosol Level 1 • AL2 -Aerosol Level 2 • AL3-, Aerosol Level 3 C: Cryogenics .CA: Carcino~ens CABS: Safety Cabinets • Approved/listed gas cabinets • Approved/listed flammable liquids storage cabinets • Approved/listed hazardous materials storage cabinets CD: Combustib!e Dusts CF: Combustible Fibers CG; Compressed Gases CL: Combustible Liquids • CL2 -C9mbustible Liquids II • CL3A -Comqustible Liquids Ill-A ~ CL3B -Combustible Liquids 111-B CONC %: Concentration CP: Consumer Product -Not Regulated CR. or COR: Corrosive CRY: Cryogenics • CRYF -Cryogenic Flammable • CRYO -Cryogenic Oxidizer EX: Explosive FG: Flammable Gas - Gaseous FGL: Flammable Gas - Liquefied · FL: Flammable Liquid • FL 1 A -Flammable Liquid 1-A • FL 1 B -Flammable Liquid 1-B • FL 1 C -Flammable Liquid 1-C • Combination -IA + 1 B + 1 C FS: Flammable Solid G: Gas Haz Class: Hazard Classification HR: Hazard Ranking • F -Flammability' • H-Health • R· -Reactivity 1-:fT: Highly Toxics IR: Irritants L: Liquid LG: Liquefied Gas LOC: Location/Control Area Name: • Chemic·aJ Name • Material Name • Product Name NFP: No Fire Point NH: Non-hazardous OHH: Other·Health Hazards OP -Organic Peroxidl:!s • UD -Unclassified Detonable • OP1 -Organic Peroxide I • OP2 -Organic Peroxide II • OP3 -Organic Peroxide Ill • OP4 -Organic Peroxide IV • OPS -Organic Peroxide V OX: Oxidizer • OX -Oxidizer Gas • OX1 -Oxidizer 1 •, OX2 -Oxidizer 2 • OX3 -Oxidizer 3 • OX4 -Oxidizer 4 PY: Pyrophoric RAD: Radioactive • RADA -Alpha • RADB-Beta .• RADG -Gamma S: Solid SN: Sensitizers State: Material/Physical State TX: Toxic UC: Use-Closed System UO: Use-Open System Units: • Cu-Curies • Cf -Cubic Feet • Gins -Gallons • Lbs -Pounds • MCc -Microcuries • MCi -Millicunes UR: Unstable Reac;tive • UR1 -Unstable Reactive 1 • UR2 -Unstable Reactive 2 • UR3 -Unstable Reactive 3 • UR4 -Unstable Reactive 4 WR: Water Reactive • WR1 -Water Reactive 1 • WR2 -Water Reactive 2 • WR3 -Water Reactive 3 >15 psi: Pressure @ >15 psig • CL Pressurized @ >15 psig • FG Pressurized@ >15 psig • FL pressurized@ >15 psig California & Federally Regulated Chemicals, Materials & Substances: • P65: California Proposition 65 chemicals identified in California as Carcinogens or Reproductive/ Developmental Toxins [OHHJ • PSM: OSHA Process Safety Management Acutely Hazardous Materials • RMP-T1: Federal Regulated Substances for Accidental Release Prevention · • RMP-T2: Federal Regulated Flammable Substances for Accidental. Release Prevention • RMP-T3: California Regulated Substances for Accidental Release Prevention NOTE: • Includes products/ mixtures/ . materials containing regulated chemicals, materials & substances. • Includes materials. chemicals & substances identified through CAL- ARP in California. • Reporting/disclosure through CUPRA and/or Local/County/State Health or other agencies may be necessary -i.e.: Business Plan [BP], Risk Man·agement Plan [RMPJ or both. TEriksen-Rattan Associates Inc. 4719 Palm Avenue-La Mesa, California 91941 Telephone 619.466.6285 FAX 619.622.6233 EMAIL MaryRattan@thecoderesource.com or MaryRattan@covad.net 1/01 ) I I I I I i ' I I ISiS PHARMACEUTICALS -1891 Rutherford, Carlsbad CA UNIFORM/CALIFORNIA CODES ANALYSIS -IBIS LAB BUILD-OUT Alternate Method.of Compliance: Conditions intended t~:rprovide materials or methods.equivalent to the literal conditions set forth in the Code, as recognized through USC/CBC 104.2.8 and/or UFC/CFC 103.1.2. Approved: Approval by/acceptable to the authority having jurisdiction [Fire Chief and/or Building Official, as applicable], as the result of review investigation or tests conducted by the authority having jurisdiction, or by reason of accepted principles or tests by national authorities or technical or scjentific organizations . . Container -Liquid: </=60-gallon ~pacify. . Control-Area: A building or portion of a building within which the exempt amounts cif hazardous materials are allowed to be stored, dispensed, used or handled. A Control Area is generaliy addressed as a non-H Occupancy and ·classified as a 8, For S Occupancy, depending oo the operations/conditions involved. Each building is allowed to · have up to 4 Control Areas. ' Drum -Liquid: </=60-gallon capacity. Exempt Amounts per Control Area -Hazardous Materials: Types and amounts of materials allowed to be stored, dispensed, used or handled without application of H Occupancy or material hazard specific controls. Exempt Amounts are as idf;!ntified in USC/CBC Tables 3-D & 3-E and UFC/CFC Tables 7902.2-5A, 7903.2-8, 7903.3-A, · 8001.15-A, 8001.15-8, 8001.15-C & 8001.15-D, with the amounts and conditions indicated allowed in each Control Area, with each building allowed to have 4 Control Areas. Exit: The exit is that portion of ,the means of egress system between the exit access and the exit discharge or the public-way. Some of the components that may be selectively included in the exit include exterior exit doors, exit enclosures, exit passageways and horizontal exits. Exit Access: The exit access is that portion of a means of egress system between any occupied point in a building/structure and a door of the exit. Some of the components that may be selectively included in the exit access include aisles, hallways and corridors. Exit Discharge: The exit discharge is that portion of the means of egress system between the exit and the public · way. Some of the components that may be selectively included in the exit discharge include exterior exit balconies, exterior exit stairways, exterior exit ramps, exit courts and yards. Exit Discharge-Safe Dispersal Area: An area on the same property as·the building being exited, with the proximity and si?!e of the safe dispersal area based on factors such as the occupant load served, mobility of the occupants, building construction .type, building fire-protection features, building height and degree of hazard of the occupancy/use; with the safe dispersal area located >/=50' fromthe building served. lncompatible·Materials: Materials which, when in.contact with eac,h other, have the potential to react in a manner that generates heat, fumes, gases or byproducts which are ·hazardous to· life or property. Future: Conditions addressed in this report for work/operations that will-be submitted separately for plan review/ permitting, with plans not included as part of the initial plan review/permit documents. Labeled: Equipment or material to which hc1s been attached a label, symbol or other identifying mark of a nationally recognize·d testing laboratory, i_nspection agency or other organization concerned with product evaluation that maintains periodic inspection of prodlJction of labeled eqllipment or Materials, and by whose labeling is indicated compliance with nationally recognized standards or tests to determine suitable .usage in a specified manner. Listed: Equipment of Materials included on a list published by a nationally recognized testing laboratory, inspection · agency or other organization concerned with product evaluation that maintains periodic inspection of production or 'listed equipment or Materials, and whose listing states that equipment or Mc1teriais meet nationally recognized standards and have been tested and found suitable for use in a specified manner. Means of Egress: An exit systemthat provides a continuous, unobstructed and undiminished path of exit travel from any occupied point in a building/structure to a public way. A means of egress system consists of 3 separate and distinct elements: Exit Access, Exit, Exit Discharge Occupancy -A3: Assembly rooms/areas with an occupant load of >/=50 and <300.without a legitimate stage, · including rooms/areas ·used for educational purposes -i.e.: cafeterias, classrooms, conference rooms, libraries, lobbies. · Occupancy -B: Office, employee, administrative areas; labs; ancillary support operations. Occupancy -F1: Moderate hazard manufacturing/industrial operations for assembling, disassembling, fabricating, · · · finishing, manufacturing, packaging, repair or processing ope_rations that are. not classified as H Occupancies. Occupancy -S1: Moderc!te hazard storage operations that are not classified as Group H Occupancies. Owner: Isis Pharmaceuticals. Storage: Product in closed vessels, with vessels not normally connected to piping for liquid transfer operations or not normally connect!;!d to systems or equipment involved in use operations. 'Use-Closed: Product in vessels·or systems that are normally closed under conditions where product in the vessels or systems is not normally exposed to the atmosphere of the room or area in which the vessels/systems are located- i.e.: normally closed processes/vessels; liquid•transfer into_ closed processes/vessels through a piping system. 1sIs Pharmaceuticals/Control Area 2 .-Ibis Lab/1891 Rutherford, Carlsbad CA Nonflammable Vapor Exhaust Conditions -Class I Flammable Liquids CONTROL AREA 1 -Room L 114 CFM Required for Vapor-Air Mixtures@ </=10% LFL In Exhaust Ducts Material LFL 10% ofLFL Volumes of Air Specific Vapor Cubic Feet of Exhaust Evaporation Time Spill CFMtoKeep to One Volume Gravity Density Ventilation Air Needed to Assumed* Scenario Evaporated Liquid at of Vapor Keep @10% LFL Per Gal of (Minutes) (Gallons) 1 O'Y• LFL If All of the Liquid Evaporated Liquid Is Evaporated Acetone [67-54-1 J 2.6 0.2600 383.6154 0.7860 2.0100· 16270.3103 8.8067 0.2642. 488.1093 Acetonitrile [75-05-8] 3 0.3000 332.3333 0.7860 1.4100 20018.7820 8.8067 0.2642 600.5635 Dioxane [123-91-1] 2 0.2000 499.0000 1.0340 3.0500 18450.1762 8.8067 0.2642 553.5053 Ethanol [64-17-5] 3.~ 0.3300 302.0303 0.7890 1.5940 16109.6075 8.8067 0.2642 483.2882 Ethyl Ether [60-29-7] 1.9 0.1900 525.3158 0.7130 2.6000 15725.8934 8.8067 0.2642 471.7768 Hexane [110-54-3] 1.1 0.1100 908.0909 0.6550 2.9830 21926.8069 8.8067 0.2642 657.8042 lsopropanol [67-63-0J. 2 0.2000 499.0000 0.7890 2.0790 20653.9125 8.8067 0.2642 619.6174 Methanol [67 ~56-1] 6 0.6000 165.6667 0.7910 1.1090 12410.9572 8.8067 0.2642 372.3287 Pyridine [110-8&-1] 1.8 0.1800 554.5556 0.9780 2.7200 21,786.7611 8.8067 0.2642 653.6028 Tetrahydrofuran [109-99-9] 1.8 0.1800 554.5556 0.8890 2.5000 21546.8840 8.8067 0.2642 646.4065 Toluene [108-88-3] 1.1 0.1100 908.0909 0.8650 3.2000 26993.1441 8.8067 0.2642 809.7943 CFM Required for Vapor-Air Mixtures @ </=25% LFL In Work Area and Exhaust Ducts Cubic Feet of Exhaust Spill CFMto Keep Material LFL 25%ofLFL Volumes of Air Specific Vapor Ventilation Air Needed to Evaporation Time Scenario Evaporated Liquid @ to One Volume Gravity Den~lty Keep@ 25% LFL Per·Gal of Assumed* (Gallons) 25% LFL If.All of the of Vapor Liquid Evaporated ("1Inutes) Llquld.-Is Evaporated Acetone [67-54-1] 2.6 0.6500 152.8462 0.7860 2.0100 6508.1241 8.8067 0.2642 195.2437 Acetonitrile [75-05-8] 3 0.7500 132.3333 0.7860 1.4100 8007.5128 8.8067 0.2642 . 240.2254 Dioxane [123-91-1] 2 0.5000 199.0000 1.0340 3.0500 7380.0705 8.8o6r 0.2642 221.4021 Ethanol [64-17-51 3.3 0.8250 120.2121 • 0.7890 1.5940 6443.8430 8.8067· 0.2642 193.3153 Eth~ Ether [6(!.729-7] · 1.9 0.4750 209.5263 Q.7130 2.6000 6290.3573 8.8067 0.2642 188.7107 Hexane [110-54-3] 1.1 0.2750 362.6364 0.6550 .2.9830 8770.7227 8.8067 0.2642 263.1217 lsoptopanol [67-63-QJ 2 0.5000 199.0000 0.7890 2.0790 8261.5650 8.8067 0.2642 247.8469 Methanol [67-56-1] 6 1.5000 65.6667 0.7910 1.1090 4964.3829 8.8067 0.2642 148.9315 '. Pyridine [110-86-H 1.8 · o .. 4.500 221.2222 0.9780 2.7200 8714.7044 8.8067 0.2642 261.4411 Tetrahydrofuran [10.9-99-9] 1.8 0.4,500 221.2222 0.8890 2.5000 8618.7536 8.8067 0.2642 258.5626 Toluene [108-88-3] 1.1 0.2750 362.6364 0.8650 3.2000 10797.2577 8.8067 0.2642 323.9177 11/13/01 [Rev. 1] -Page 1 of 10 T:; ~' *:1~;:;~'.'~!Jf L ;;~:liH! .... ~ . : :,, ::) :,·· ./{·: --------------·------ Isis Pharmaceuticals/Control Area 2 -Ibis Lab/1891 Rutherford, Carlsbaµ CA Nonflammable Vapor Exhaust Conditions -Class I Flammable Liquids CONTROL AREA 2 CFM Required for Vapor-Air Mixtures@ </=10% LFL in Exhaust Ducts Material LFL 10%ofLFL Volumes of Air Specific Vapor Cubic Feet of Exhaust Evaporation Time Spill CFM to Keep to One Volume Gravity Density Ventilation Air Needed to Assumed* Scenario Evaporated Liquid at of Vapor Keep @10% LFL Per Gal of (Minutes) (Gallons) 10% LFL If All of the Liquid Evaporated Liquid Is Evaporated Acetone (67-54-1) 2.6 0.2600 383.6154 0.7860 2.0100 16270.3103 8.8067 0.2642 488.1093 Acetonilrile '[15-05-8] 3 0.3000 332.3333 0.7860 1.4100 20018.7820 8.8067 0.2642 600.5635 Aliyi Alcohol [107-18-6] 2.5 0.2500 399.0000 . 0.8540 2.0100 18403.9124 8.8067 0.2642 552.1174 Aiiyl Bromide (106-95-6) 4.4 0.4400 226.2727 1.4300 4.2000 8216.2889 0.6667 0.0200 246.4887 Aminopropene [107-11-9) 2.2 0.2200 453.5455 0.7610 1.9760 19015.0569 0.6667 0.0200 570.4517 Ammonium Sulfide 5 0.5000 199.0000 0.9970 2.3580 8922.5440 2.3333 0.0700 267.6763 [12135-76-1] Amyl Alcohol [75-85-4] 1.2 0.1200 832.3333 0.8059 3.0000 24537.7119 8.8067 0.2642 736.1314 BBN [280-64-8) . See Hexanes, Tetrahydrofuran, toluene Benzene [71-43-2] 1.3 0.1300 768.2308 0.8740 2.7700 26606.5891 8.8067 0.2642 798.1977 Borane Methyl Sulfide Complex 2 0.2000 499.0000 0.8010 2.9800 -14628.3745 1:6667 0.0500 438.8512. [13202-87-0] · Bromoelhyl Methyl Ether 4 0.4000 249.0000 1.4790 3.5000 11264.0640 0.0033 0.0001 337.9219 [6482-24-2] ., Bromo-2-Methyl-2-Buteile 4 0.4000 249.0000 1.2930 3.0000 11488.7360 0.6667 0.0200 344.6621 [870-63-3) Bromotrimethylsilane-[4342-2 0.2000 499.0000 . 1.0500 3,5000 .16326.8000 2.0000 0.060Q 489.8040 61-4] BSA [10416-59-8] 5 0.5000 199:0000 0.8320 3.7500 4681.9783 0.8800 0,0264 140.4593 Butanol) [71-36-3] 1.4 0.1400 713.285.7 0.8100 2.6000 24369.3692 8.8067 0.2642 731.0811 Bromoeth;me [74-96-4] 6.75 0.6750 147.1481 1.4600 3.7500 5973.7961 0.8800 0:0264 179.2139 Butylamine [103-73-9] 1.7 0.1700 587.2353 0.7400 2.2500 21122.1215 8.8067 0.2642 633.6636 Butyl Isocyanate [1609-86-5] 3 0.3000 332.3333 0.8440 . 2.2000 13776.9786 0.0033 ·0.0001 413.3094 Carbon Disulfide [75-15-0] 1.3 0.1300 768.2308 1.2660 2.6700 26606.5891 8.8067 0.2642 798.1977 Chlbroacetald~hyde Dielfiyl 5 0.5000 199.0000 1.1080 2.0000 11690.8773 0.6667 0.0200 350.7263 Acetal [621-62-5] Chlorobenzene [108-90-7) 1.3 0.1300 768.2308 1.1060 3.8600 24161:5817 8:8067 0.2642 724.8474 Chlorotrimethylsilane [75-77-4) 2 0.2000 -499.0000 0.8590 6.7000 6977.4732 8.8067 0.2642 299.3242 Cydobuytyla111ine· [2516-34-9] 2 0.2000 499.0000 0.8330 3.0000 151'11.3604 0.6667 0.0200 453.3408 Cyclohexane [110-82-7] 1.3 0.1300 768.2308 0.7790 2.9000 22651.5016 8,8067 0.2642 679.5450 Cyclohexylamine [108-91-8] 1.5 0.1500 665.6667 0.8670 -3.4320 · 18424.7044 1.0000 0.0300 552.7411 Existing Labs -Lab 110//Mass Spectrometry: Ethanol & lsopropanol only..,. no use/transfer of Class I, II or Ill-A Liquids in.other areas. New Labs -BSL-2 Labs/L115 & L116 and Lab 107/0peri Lab: Class I, II and Ill-A Liquids -no use/transfer-of Class·l, 11 or Ill-A Liquids In other areas. 11/13/01 (Rev. 1) • Page 2 of 10 !~ ;;,y:\~,~tt~::~; ~'. :Jiif~i ;r ···,' ---------.. --.. ------- , Isis Pharmaceuticals/Control Area 2 -Ibis Lab/1891 Rutherford, Carlsbad CA Nonflammable Vapor Exhaust Conditions -Class I Flammable Liquids . CONTROL AREA2 CFM Required for Vapor-Air Mixtures@ <1=10% LFL in Exhaust Ducts Material LFL 10%ofLFL Volumes of Air Specific Vapor Cubic Feet of Exhaust Evaporation Time Spill GFMtoKeep to One Volume Gravity Density Ventilation Air Needed to Assumed* Scenario Evaporated Liquid at , of Vapor Keep@10% LFL Per Gal of (Minutes) (Gallons) 10% LFL If All of the Liquid Evaporated Liquid Is Evaporated Dichloroethane [107-06-2) 6.2 0.6200 160.2903 1.2560 3.4000 6207.3411 8.8067 0.2642 186.2202 Dlchlorotetramethyldlsllane [4342 5 0.5000 199.0000 0.8000 1.0050 16798.1426 0.6667 0.0200 503.9443 61-4) Dlethylamine [109-89-7] 3.3 0.3300 302.0303 0.7070 2.5310 9091.2487 0.6667 0.0200 272.7375 Dihydropyran (110-87-2] 1.1 0.1100 908.0909 0.9280 2.9110 25934.1395 0.6667 0.0200 778.0242 Diisopropylamine [108-18-9] 1.1 0.1100 908.0909 0.7220 3.5000 20599.4914 8.8067 0.2642 617.9847 Dllsopropylcarbodiimide 2 0.2000 499.0000 0.8060 4.3680 10042.2778 0.6667 0.0200 301.2683 [693-13-0) Dilsopropylethylamine 2 0.2000 499.0000 0.7420 4.4720 9029.8790 8.8067 0.2642 270.8964 [7087-68-5) ;. Dimethoxypropane [77-76-9) 6 0.6000 165.6667 0.8470 3.5900 4105.3416 8.8067 0.2642. 123.1602 Dimethylamine [124-40-3) 2.8 0.2800 356.1429 0.9380 1.5600 9273.2123 2.0000 0.0600 278.1964 Dfmethylaminopropylamlne [109-3 0.3000 332.3333 0.8120 3.6000 8100.0509 0.4400 0.0132 243.0015 55-7] Dimethylisopropyfamlne 2 0,2000 499.0000 -0.7150 2.0000 7782.4413 2.0000 0.0600 233.4732 [996-35-0) Dioxane [1~3-91-1] · 2 0.2000 499.0000 1.0340 . 3.0500 18450;1762 8.8067 0.2642 553.5053 Ethanol [64-17°5] 3.3 0.3300 302.0303 0.7890 1.5940 16109.6075 8.{)067 . 0.2642 483.2882 Ethyl Acetate [141-7_8-5] 2.2 0.2200 453.5455 0.9020 3.0000 14845.1707 2.0000 0.0600 445.3551 Ethylenedlamine [107 015-3) .2:1 0.2700 369.3704 0.8890 2.0700 17189.5390 2.0000 0.0600 515.6862 Ethylene Glycol Dimethyl Etther 2 0.2000 499.0000 0.8670 2,2000 21447..4782 8.8067 · 0.2642 643.4243 [11Q~71-4] -· Ethyl Ether [60-29-7) 1.9 0.1900 525.3158 0.7130 2.6000 15725.8934 2.3767 0.0713 471.7768 Ethylglocolate [!;124-44-7] See Toluene Fu rim (110-00-9) 2.3 0.2300 433.7826 0.9360 2.3000 19199.8784 0.8800 0.0264 575.9964 Heptanemethylenelmine 3 . 0.3000 332.3333 0.8900 2.2000 14527.8566 7.3333 0.2200 435.8357 [1121-92~21 Hexane [110-54-3] 1.1 0.1100 908.0909 .. 0.6550 2.9830 21926.8069 8.8067 0.2642 657.8042 Hexanes '[73513-42-5] 1.1 · 0.1100 908.0909 . 0.6720 3.0000 22368.4228 8.8067 0.2642 671.0527 -lsobutyryl Chloride [79-30-1] 2 0.2000 499.0000 1.1070 3.6870 6536.0338 4.3333 0.1300 196.0810 :; .'• lsopropanol [67-63~0] 2 0.2000 499.0000 0.7890 .2.0790. 20653.9125 8.8067 0.2642 ~19.6174 lsopropylamine [75-:31-0] 2 0.2000 499.0000 0.6940 2.0400 18514.3778 4.3333 0.1300 555.4313 lsopropyf Isocyanate [1795-2 0.2000 499.0000 0.8680 2.2000 21472.2158 0.1833 0.0055 644.1665 4!!-8]. Existing Labs -Lab :U0I/Mass Spectrometry: Ethanol & lsopropanol only -no useltransfer of Class I, II or lll•A Liquids in other areas. New Labs -BSL-2 Labs/L 115 & L 116 and Lab 1071Open Lab: Class.I, II and Ill-A Liquids -no uisettransfer of Class I, II or Ill-A Liquids in·other areas. 11/13/01 [Rev.1] -Page 3 of 10 f{i6: ;;;,~;t~i :~ -:.··· : t.' r ------------------- _Isis Pharrriaceuticals/Coritrol Area 2 -Ibis Lab/1891 Rutherford, Carlsbad CA Nonflammable Vapor Exhaust Conditions -Class I Flammable Liquids CONTROL AREA 2 CFM Required for Vapor0Air Mixtures @ </=10% LFL In Exhaust Ducts Material LFL 10%ofLFL Volumes of Air Specific Vapor Cubic Feet of Exhaust Evaporation Time Splll CFMto Keep to One Volume Gravity Density_ Ventilation Air Needed to Assumed* Scenario Evaporated Liquid at of Vapor Keep @10% LFL Per Gal of (Minutes) (Gallons) 10o/e LFL if All of the Liquid Evaporated Liquid Is Evaporated Lithium Borohydride See Tetrahydrofuran [1649-15-8] Lithium Dlisopropylamide (4111-See Ethylbenzene, Heptane, Tetrahydrofuran]+B36 54-0] Methanol (67-56-1] 6 0.6000 165.6667 0.7910 1.1090 12410.9572 8.8067 0.2642 372.3287 Methyl Acrylate [96-33-3] 2.1 0.2100 475.1905 0.9560 3.0000 16499.9935 2.3333 0.0700 494.9998 Metliylhydrazine (60-34-4] 2.5 0.2500 399.0000 0.8660 1.5940 23533.0339 0.6667 0.0200 705.9910 Methylmorpholine (109:02-4] 3 0.3000 332.3333 0.9200 3.5000 9439.6089 3.5233 0.1057 283.1883 Methyl-2-Propanol (75-65-0] 2.4 0.2400 415.6667 0.7750 2.5000 14001.8044 4.3333 0.1300 420.0541 Methylpyrrolidone (120-94-5] 2.4 0:2400 415.6667 0.8190 2.1000 17615.1733 8.8067 0.2642 528.4552 Methyl Sulfide [75-18-3] 2.2 0.2200 453.5455 0.8460 2.5000 16708.2231 0.7333 0.0220 501.2467 Methylthlotrimethylsilane 3 0.3000 332.3333 0.8480 , 2.2000 13842.2723 0.0033 0.0001 415.2682 (3908-55-2] Nitr_omethane [75-52-5] 7.3 0.7300 135.9863 1.1270 2.1000 7569.1173 8.8Q67 0.2642 227.0735 Pentane r109:5s-o] 1.4 0.1400 713.2857 0.6260 2.4970 19610.4883 8.8067 0.2642 588.3146 . Pheriylmagneslum Bromide (100-See Ethyl Ether 58-3] Piperdlne [110-89-4] 2 · . 0.2000 499'.0000 0.8610 2.9460 15905.6062 8.8067 0.2642 477.1682 Propylamlne [107-10-8] 2 .. 49.0000 . 0.6260 0.7170 2.0450 19081.1990 3.0000 0.0900 572.4360 Pyridine [110-86-1] 1.8 0.1800 554.5556 0.9780 2,7200 21786.7611 8:8067 0.2642 653.6028 Pyrrolldine (123-75-1] 1.6 0.1600 .624.0000 0.8600 2.4500 ,23976.8000 0.6667 0.0200 719.3040 Sodium Cyanoborhydride [25895-. See Tetrahydrofuran 60-7] Sodium Methoxide (124-41-4] See Methanol TEMED (110-18-9] 0.98 I 0.0980 1019.4082 I ·0.1100 4.0220 21484.6975 0.0033 0.0001 644.5409 Tetrabutylamrnonium Fluoride See Tetrahydrofuran (429-41-4) Tetrahydrofurari [109-99-9] 1.8 0.1800 554.5556 0.8890 2.5000 21546.8840 8.8067 0.264,2 646.4065 TMS Triflate (276077-77-8] 5 0.5000 199.0000 0.9000 1.2280 15466.1238 8.8067 0.2642 463.9837 Toluene (108-88-3] 1.1 0.1100 908.0909 0.8650 3.2000 26993.1441 8.8067 0;2642 809.7943 Triethoxymethane [122-5:1-0] 2 0.2000 499.0000 0.8910 5.1100 9489.3534 8.8067 0.2642 284.6806 Trlethylamlne (121-44-8] 1.2 0.1200 832.3333 0.7260 3.5000 18968.2,827 8.8067 0.2642 569.0485 Existing !,.abs • Lab 110/IMass Spectrometry: Ethanol & lsopropanol only •• no use/transfer of Class I, II or Ill-A Liquids In other areas. New Labs -BSL-2 Labs/L115 & L116 and Lab 107/Open Lab: Class I, II and Ill-A Liquids -no use/transfer of Class I, II or Ill-A Liquids In other areas. 11i13/01 [Rev. 1) -Page 4 of 10 f}!Ji!~r ;J ·.: ·. ---··----·--·---------- Isis Pharmaceuticals/Control Area 2 -Ibis Lab/1891 Rutherford, Carlsbad CA Nonflammable Vapor Exhaust Conditions -Class I Flammable Liquids CONTROL AREA 2 CFM Required for Vapor-Air Mixtures@ </=10°/4 LFL in Exhaust Ducts Material LFL 10% of LFL Volumes of Air Specific Vapor Cubic Feet of Exhaust Evaporation Time Spill CFM to Keep to One Volume Gravity Density Ventilation Air Needed to Assumed* Scenario Evaporated Liquid at of Vapor Keep @10% LFL Per Gal of (Minutes) (Gallons) 10% LFL if All of the Liquid Evaporated Liquid is Evaporated Trifluoroethanol (75-89-8] 5.5 0.5500 180.8182 1.3910 3.5000 7584.2378 4.3333 0.1300 227.5271 Triisopropylsllane (6485-79-6] 6 0.6000 165.6667 1.2930 3.0000 7499.5916 14.6667 0.4400 224.9877 Trimethylacetyl Chloride (3282-1.4 0.1400 713.2857 0.9690 3.6700 20653.3417 8.8067 0.2642 619.6003 30-2] Trimethyl Orthoformate 1.4 0.1400 713.2857 0.9800 3.6700 20887.7965 8.8067 0.2642 626.6339 (149-73-5] Trimethylsllyldiazomethane See Hexanes (18107-18-1] Trimethylsilylimidazole (18156-2,4 0.2400 415.6667 0.9560 2.4000 17991.5659 0.0033 0.0001 539.7470 74-6] Tripropylamine (102-69-2] 0.7 0.0700 1427.5714 0.7630 4.9000 24533.7200 0.6667 0.0200 736.0116 Zinc Chloride [7646-85:-7] See Ethyl Ether, Tetrahydrofuran Existing Labs -Lab 11 Off Mass Spectrometry Only: Ethanol only -no use of Class I, II or lll•A Liquids in other areas. New Labs -Lab 107/Open Lab Only: Cla.~s !, II and Ill-A Liquids -no use of Class I, II or Ill-A Liquids In other areas. 11/13/01.[Rev.1f-Page 5 of 10 , ,_, .... : ·_.--+: .. _:;;:.~,: .. ·;:.:'.,_-,c::.c.:~;,.,·:fi!r. _;,_;;_::; ~--i; ·. :_~ .. · ·:.?. : ,:.. -----------·-------- Isis .Pharmaceuticals/Control Area 2 -Ibis Lab/1891 Rutherford, Carlsbad CA Nonflammable Vapor Exhaust Conditions -Class I Flammable Liquids CONTROL AREA 2 CFM Required for Vapor-Air Mixtures @ </=25% LFL In Work Area and Exhaust Ducts Cubic Feet of Exhaust Spill CFM to Keep Material , LFL 25% ofLFL Volumes of Air Specific Vapor Ventilation Air Needed to Evaporation Time Scenario Evaporated Liquid @ to One Volume Gravity Density Keep @ 25% LFL Per Gal of Assumed* (Gallons) 25% LFL if All of the of Vapor Liquid Evaporated (Minutes) Liquid Is Evaporated Acetone [67-54-1) 2.6 0.6500 152.8462 Q.7860 2.0100 6508.1241 8.8067 0.2642 195.2437 Acetonitrile [75-05-8) 3 0.7500 132.3333 0.7860 1.4100 8007.5128 8.8067 0.2642 240.2254 Allyl Alcohol [107-18-6) 2.5 0.6250 159.0000 0.8540 2.0100 7361.5650 8.8067 0.2642 220.8469 Allyl Bromide [106-95-6) 4.4 1.1000 89.9091 1.4300 4.2000 3286.5156 0.6667 0.0200 98.5955 Aminopropene [107-11-9] 2.2 0.5500 180.8182 0.7610 1.9760 7606.0227 0.6667 0.0200 22,8.1807 Ammonium Sulfide 5 1.2500 79.0000 0.9970 2.3580 3569.0176 2.3333 0.0700 107.0705 [12135-76-1) Amyl Alcohol·[75-85-4] 1.2 0.3000 332.3333 0.8050 3.0000 9815.0847 8.8067 . 0.2642 294.4525 BBN [280-64-8) See Hexanes, Tetrahydrofuran, toluene Benzene [71-43-2] 1.3 0.3250 306.6923 0.8740 2.7700 10642.6356 7.3389 0.2642 383.1349 Borane Methyl Sulfide Complex • 2 0.5000 199.0000 0.8010 2.9800 5851.3498 1.6667 0.0500 175.5405 [ 13202-87-0] Bromoethyl Met~yl Ether 4 1.0000 99.0000 1.4790 3.5000 4505.6256 0.0033 0.0001 135.1688 [6482-24-2) Bromo-2-Methyl-2-Butene 4 1.0000 99.0000 1.2930 3.0000 . 4595.4944 0.6667 ·0.0200 137.864!3 [870-63-3] B.romotrlrnethylsilane [4342-2 0.5000 199.0000 1.0500 3:5000 6530.7200 2.0000 0.0600 195.9216 61-4) BSA (10416-59-8) 5 1.2500 79.0000 0.8320 3.7500 1872.7913 0.8800 0.0264 56.1837 Butanol),(71~36-3) 1.4 0.3500 284.7143 0.8100 ,, 2.6000 . . 9747.7477 8.8067 0.2642 292.4324 Brornoetl)ane [74-96-4] 6:75 1.6875 . 58.2593 · 1.4600 3.7500 2389.5184 0.8800 0.0264 71.6856 Butylamlne [103-73-9) 1.1: 0.4250 234.2941 0.7400 2.2500 8448.8486 8.6967 0.2600 ,253.4655 Butyl Isocyanate [1609-86-5) 3 0.7500 132.3333 0.8440 2.2000 5510.7914 0.3333 0.0100 165.3237 CarbOIJ Disulfide (75-15-0J 1.3 0.3250 306.6923 1.2660 2.6700 15993.3696 8.8067 0.2642 479.8011 Chloroacetaldehyde Diethyl 5 1.2500 79.0000 1.1080 2:0000 4676.3509 0.6667 0.0200 140.2905 Acetal [621-62-5] Chiorobenzene (108-90-7) 1.3 0.3250 306.6923'" 1.1060 3.8600 9664.6327 8.8067 0.2642 289.9390 Chlorotrimethylsilane [75-77-4] · 2 0.5000 1!:19.0000 0.8590 6.7000 2190.9893 8.8067 ·0.2642 83.7297 Cyclobuytylamine [2516-34-9] 2 0.5000 199.0000 0.8330 3.0000 6044.5442 0.6667 0.0200 181.3363 Cyclohexane (j10-82-7J 1.3 0.3250 306:6923 o:7790 2.9000 9060.6007 8.8067 0.2642 271.8180 Cyclohexylarnine [108-91-8) 1.5 0.3750 265.6667. 0.8670 3.4320 7369.8817 1.0000 0.0300 221.0965 Existing Labs -Lab 110//Mass Spectrometry: Ethanol & lsopropanol only-no use/transfer of Class I, II or Ill-A Liquids In other areas. New Labs -BSL-2 Labs/L 115 & L 116 and Lab 107/Opan Lab: Class I, II ~nd Ill-A Liquids -no use/transfer of Class I, II or Ill-A Liquids In other areas. 11/13/01 [Rev.1)-Page 6 of 10 \i·:··,-.. ::~ ·~:.;::~J;'.;r-:':·~:If.L. :f~i};i-lI , .... ::_ ,j, . ~ J ----·--------------- Isis Pharmaceuticals/Control Area 2 -Ibis Lab/1891 Rutherford, Carlsbad CA Nonflammable Vapor Exhaust Conditions -Class I Flammable Liquids CONTROL AREA 2 CFM Required for Vapor-Air Mixtures@ </=25% LFL in Work Area and Exhaust Ducts Cubic Feet of Exhaust Spill GFM fo Keep Volumes of Air Specific Vapor Ventilation Air Needed to Evaporation Time Evaporated Liquid @ Material LFL 25%ofLFL to One Volume Gravity Density Keep @ 25% LFL Per Gal of Assumed* Scenario 25% LFL If All of the of Vapor Liquid Evaporated (Minutes) (Gallons) Liquid is Evaporated Dicl)loroethane [107-06-2] 6.2 1.5500 63.5161 1.2560 3.4000 2482.9364 8.8067 0.2642 74.~881 Dichlorotetramethyldlsilane [4342 5 0.5000 199.0000 0.8000 1.0050 6719.2570 0.6667 0.0200 201.5777 61-4] Dlethylamlne [109-89-7] 3.3 0.8250 120.2121 0.7070 2.5310 3636.4995 0.6667 0.0200 109.0950 Dlhydropyrali [110-87-2] 1.1 0.2750 362.6364 0.9280 2.9110, 12733.6558 0.6667 0.0200 382.0097 Dlisopropylamine (108-18-9] 1.1 0.2750 362.6364 0.7220 3.5000 8239.7966 8.8067 0.2642 247.1939 Dllsopropylcarbodllmlde 2 0.5000 199.0000 0.8060 4.3680 4016.9111 0.6667 0.0200 120.5073 [693-13-0J ' Diisopropylethylallline 2 0.5000 199.0000 0.7420 4.4720 3611.9516 8.8067 0.2642 108.3585 [7087-68-5] Dimethoxypr~pane (77-76-9] 6 1.5000 65.6667 0.8470 3.5900 1642.1367 8.8067 0.2642 49.2641 Dimethylamine [124-40-3) 2.8 0.7000 141.8571 0.9380 1.5600 9273.2123 . 2.0000 0.0600 278.1964 Dimethylamlnopropylamlne (109-3 0.7500 132.3333 0.8120 3.6000 3240.0203 0.4400 0.0132 97.2006 55-7] •,:·· Dimethyllsopropylamlne 2 0.5000 199.000Q. 0.7150 2.0000 7782:4413 2.0000 0.0600 233.4732 (996-35-0) Dloxane [123-91-1] 2 0.5000 199.0000 1.0340 3.0500 7380.0705. 8.8067 0.2642 221.4021 . Ethanol (64-17-5] 3.3 0.8250 120.2121 0.7890 1.5940 6443.8430 8.8067 0.2642 193.3153 Ethyl Ace'3te [141-78-5] 2.2 0.5500 180.8182 0.9020. 3.0000 5938.0683 2.0000 0.0600 178.1420 Ethy!enediamlne (107-15-3) 2.7 0.6750 147.1481 0.8890 2.0700 · 6875.8156 2.0000 0.0600 206.2745 Ethylene·Glycol Dimethyl Etther' 2 0.5000 199.0000 0.8670 2.2000 8578.~913 ~.8067 0.2642 257.3697 [110-71-41 Ethyl Ether (60-29-7] 1.9 0.4750 209.q263 0;7130 2.6000 6290.357~ 2.3767 0.0713 188.7107 , Ethylglocolate,[924-44-7] ~eeToluene Furan (110-00-9] , 2.3 0.5750 172.9130 0.9360 2.3000 ·7679.9514 0.8800 0.0264 230.3985 Heptaneinethylerielmlne 3 0.7500 132.3333 0.8900 2.2000 · 5811.1426 7:3333 0.2200 174.3343 [1121-92-2] Hexane [11 0c54-3J 1.1 . 0.2750 362.6364 0:6550 2.983() 8770.7227 8.8067 0.2642 263.1217 Hel(anes (73513-42-5] 1.1 0.2750 362.6364 0.6720 3.0000 8947.3691. 8.8067 0.2642 268.4211 lsobutyryl Chloride [79-30-1] 2 . 0.5000 . 199.0000 1.1070 3.6870 6536.0338 4;3333 0.1300 196.0810 lsopropanol (67-63-0J 2 0.5000 199.0000 0.7890 2.0790 8261.5650 8.8067 0.2642 247.8469 lsopropylainlne [75-31-0] 2 0.5000 199.0000 0.6940 2.0400 7405.7511 4.3333 0.1300 222.1725 lsopropyl Isocyanate [1795-2 0.5000 199:0000 0.8680 2.2000 8588.8863 0.1833 0.0055 257.6666 48-8] ,· Existing Labs -Lab 11011Mass Spectrometry: .Ethanol & lsoprop11nol only -no use/transfer of Class I, II or Ill-A Liquids In other areas. New Labs -BSL-2 Labs/L 115 & L 116. and Lab 107/Open Lab: <;lass I, II and Ill-A Liquids -no use/transfer of Class I, ii or Ill-A Liquids in olher areas. 11/13/01 [Rev.1) -Paget of 10 ... ff.·.:: ,_<;i?·):1Jr::.~;r:~·~y;;;~ :-;;:_, ,:··)1i;jij). '.] ':; :-.· ----------1111111 -------- Isis Pharmaceuticals/Control Area 2 -Ibis Lab/1891 Rutherford, Carlsbad CA Nonflammable Vapor Exhaust Conditions -Class I Flammable Liquids - CONTROL AREA 2 CFM Required for Vapor-Air Mixtures @ </=25°/o LFL in Work Area and Exhaust Ducts Cubic Feet of Exhaust Spilt CFM to Keep Material LFL 25%ofLFL Volumes of Air Specific Vapor Ventilation Air Needed to Evaporation Time Scenario Evaporated liquid @ to One Volume Gravity Density Keep @ 25% LFL Per Gal of Assumed* (Gallons) 25'Y, LFL if All of the of Vapor Liquid Evaporated (Minutes) Liquid Is Evaporated Lithium Borohydride See Tetrahydrofuran (1649-15-8] Lithium Dilsopropylamide [4111-See Ethylbenzene, Heptane, Tetrahydrofuran 54-0] Methanol [67-56-1] 6 1.5000 65.6667 0.7910 1.1090 4964.3829 8.8067 0.2642 148.9315 Methyl Acrylate [96-33-3) 2.1 0.5250 '189.4762 0.9560 '3,0000 6599.9974 2.3333 0.0700 197.9999 Methylhydrazine (60-34-4] 2.5 0.6250 159.0000 0.8660 1.5940 9413.2136 0.6667 0.0200 282.3964 Methylmorpholine (109-02-4] 3 0.7500 132.3333 0.9200 3.5000 3775.8436 3.5233 0.1057 113.2753 Methyl.2-Propanbl [75-65-0] 2.4 0.6000 165.6667 0.7750 2.5000 5600.7218 4.3333 0.1300 168.0217 Methylpyrrolidone (120-94-5] 2.4 0.6000 165.6667 0.8190 2.1000 7046.0693 8.8067 0.2642 211.3821 Methyl Sulfide [75-18-3] 2.2 0.5500 180.8182 0.8460 2.5000 6683.2893 0.7333 0.0220: 200.4987 Methylthiotrimethylsilane 3 0.7500 132.3333 0.8480 2.2000 5536.9089 · 0.0033 0,0001 166.1073 (3908-55-2] Nitromethane [75-52-5] 7.3 1.8250 53.7945 1.1270 2.1000 3027.6469 8.8067 0.2642 90.8294 Pentane (109-66-0] 1.4 0.3500 _2_84.7143 0.6260 2.4970 7844.1953 8.8067 0.2642 235.3259 Phenylmagnesium Bromide (100 See Ethyl Ether 58-3] ,· Piperdlne (110-89-4] 2 0.5000 199.0000 -0.8610 2.9460 6362:2425 8:8067 0.2642 . 190.8673 Propylamine (107-10-8] 2 0.5000 0.6260 0.7170 2.0450 7632.4796 3.0000 0.0900 228.9744 · Pyridine (110~86-1] 1.8 0.4500 221.2222 0.9780 2.7200' 8714.7044 8.8067 0.2642 261.4411 Pyrrolidine [123-75-1] 1.6 o.~ooo 249.0000 0.8600 2.4500 9590.7200 0.6667 0.0200 . 287.7216 Sodium Cyanoborhydride (25895-SeeTetrahydrofuran . 60-7] Sodium Methoxide-(124-41-4] See Methanol, TEMED (110-18-9] 0.981 0.2450 407.1633 0.7700 4.0220 85,93.8790 0.3333 0.0100 257.8164 Tetrabutylammonium Fluoride SeeTetrahydrofuran (429-41-4] Tetrahydrofuran (109-99-91, . 1.8 0.4500 221.2222 0.8890 2.5000 . 8618.7536 8.8067 0.2642 258.5626 TMS Triflate [276077-77-8] 5 1.2500 79.0000 0:9000 1.2280 6186.4495 8.8067 -0.2642 185.5935 · Toluene (108-88-3] 1.1 0.2750 362.6364 0.8650 3.2000 . 10797.2577 8.8067 0.2642 323.9177 Triethoxymethane [122-51-0] 2 0.5000 199.0000 0.8910 5.1100 3795.7414 8.8067 0.2642 113.8722 Triethytamine [121-44-8] 1.2 0.3000 332.3333 0.7260 3.5000 7587.3131 8.8067 0.2642 227.6194 Existing Labs -Lab 110//Mass Spectrometry: Ethanol & lsopropanol only -rio use/transfer of Class I, II or Ill-A Liquids In other areas. New labs -BSL-2·Labs/L 115 & L 116 and Lab 107/0pen Lab: Class I, II and Ill-A Liquids -no use/transfer of Class I, II or Ill-A Liquids in other areas. 11/13/01 [Rev.1)-Page8 of 10 'H}2t;: -~ :, ; -,-.'J(r_:~-?~¥i!:::i1~::·:'.~:~!E~!Y -ll!ilfU-. ·J ---------.. --.... -------- Isis Pharmaceuticals/Control Area 2 -Ibis Lab/1891 Rutherford, Carlsbad CA Nonflammable Vapor Exhaust Conditions -Class I Flammable Liquids CONTROL AREA 2 CFM Required for Vapor-Air Mixtures @ </=25% LFL. in Work Area and Exhaust Ducts Cubic Feet of Exhaust Spill CFM to Keep Material LFL 25% ofLFI., Volumes of Air Specific Vapor Ventilation Air Needed to Evaporation Time Scenario Evaporated Liquid @ to One Volume Gravity Density Keep @ 25°/4 LFL Per Gal of Assumed* 251/4 LFL if All of the of Vapor Liquid Evaporated (Minutes) (Gallons) Liquid is Evaporated Trifluoroelhanol [75-89-8] 5.5 1.3750 71.7273 1.3910 3.5000 3033.6951 4.3333 0.1300 91.0109 Triisopropylsjlane [6485-79-6] 6 1.5000 65.6667 1.2930 3.0000 2999.8366 14.6667 0.4400 89.9951 Trimethylacetyl Chloride [3282-1.4 0.3500 284.7143 0.9690 3.6700 8261.3367 8.8067 0.2642 247.8401 30-2] Trlmethyi Orthoformate 1.4 0.3500 284.7143 0.9800 3.6700 8355.1186 8.8067 0.2642 2q0.6536 [149-73-5] Trimethylsilyldiazomethane See Hexanes [18107-18-1] Trimethylsilylimidazole [18156-2.4 0.6000 165.6667 0.9560 2.4000 7196.6264 0.0033 0.0001 215.8988 74-6] Tripropylamine [102-69-2] 0.7 0.1750 570.4286 0.7630 4.9000 9813.4880 0.6667 0.0200 ~94.4046 Zinc Chloride [7646-85-7] See Ethyl Ether, Tetrahydrofuran Existing, Labs -Lab 1101/Mass Spectrometry: Ethanol & lsopropanol onli -rio use/transfer of Class I, II or Ill-A Liquids In other areas. New Labs -BSL-2 Labs/L115 & L116 and Lab 107/Open Lab: Class I, II and Ill-A Liquids -no use/transfer of Class I, II or Ill-A Liquids In other areas. ·.!.;" •' 11/13/01 [Rev. 1) -Page 9 of 10 . : : ;::·:~:{df;;;~~; __ :_~f f '.i:::,; "f \~if~:·~:-~:~;· >~-:: : t -----------.. -------- Isis Pharmaceuticals/Control Area 2 -Ibis Lab/1891 Rutherford, Carlsbad CA Nonflammable Vapor Exhaust Conditions • Class I Flammable Liquids Spill Scenario: Evaportatlon Time -Worst Case Conditions: Definitions: Calculations 10% LFL: Calculatio~~ 25% LFL: Control Area 1/Room L 114 Worst Case Conditions: Control Area 2 Worst c,se Based on largest liquid transfer amount or largest containers, whichever is less --worst case use-open conditions. Hood Face Velocity: >/=100 fpm Spill Depth: </=1/4" Temperature: </=72oF Evaporation Rate: </=0.0005 gin/sec CFM -Cubic Feet of Exhaust Ve11tilatlon Needed to Keep Vapors @ 10% & 25% LFL per Volume of Liquid Indicated LFL = Lower Flammable Limit Reference: NFPA Fire Protection Handbook & NFPA 86 10% of LFL = 0.1xLFL Volume of Air to One Volume of Vapor= (100-10%LFL)/10°/4LFL Cubic Feet Exhaust Ventilation Needed to Keep@ 10%LFL Gallon of Liquid Evaporated= 1 0x[(8.33/0.075)]x[(specific gravity/vapttr density)] x [(100-LFL)/LFL] CFM = [Cubic Feet per Minute Exhaust Ventilation Needed to Ke,p@ 10% LFL Per Gallon of Liquid Evaporated] x [Gallons per Minute of Evaporated Liquid] Maintaining vapors at </=10°/4 LFL allows ducts to extend through othei: areas and unsprinklered/unprotected exhaust ducts. Reference: NFPA Fire·Protectlon Handbook & NFPA 86 25% of LFL = 0.25xLFL Volume of Air to Orie Volume of Vapor = (100-25%LFL)/25%LFL Cubic Feet Exhaust Ventilation Needed to Keep @ 25%LFL Gallon of Liquid Evaporated = 4x[(8.33/0,075)Jx[(speclfic gravity/vapllr density)] x [(100-LFL)/LFL] CFM = [Cubic Feet per Minute Exhaust v,ntllatiQn Needed to Keep @ 25% LFL Per Gallon of Liquid Evaporated] x [Gallons per Minute of Evaporated Liquid] · Maintaining vapors at </=25% LFL required in work areas and allows ducts to extend through other areas. 10% LFL = 809. 7943 cfm 25% LFL = 323.9177 cfm Conditions: Existing Lab L 110: 10% LFL = 746.0733 cfm 25% LFL = 298.4293 cfm New DSL-2 Labs/L115 & L116 and Open Lab L1Q7: 10% LFL = 809. 7943 cfm 25% LFL = 479.8011 cfm .. ·. _,J·, .-.,.~;;·~~'.:fH~~.::;~:!~F !.~/~~;~~-:~'.:~· ·.) ~E ......... --·-· --- 11/13/01 [Rev. 1] -Page 10·of 10 -.. _ ·----· --.. : .( . .. 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' .( ,, ''\ -·,; J, ·, ;~!·t'· :l: ..:J, -- .. ',, t=.06" SEC. A-A HORIZONTAL & DIAGONAL BRACING 5/16"0 GR. 5 BOLT "' 1 , ... ~, ~ " SEC. 8-B / a " ', " A '?- p " F ~1 "' "' "' .,, " " ', "' fi ~ p " ~ /,. .; .;.;'?-> BRACE TO COLUMN CONN. / @ 6" 8" ' . 0 " '\ \. "' @ ¾ " " "' V 0 ff, 1/ . @ p / .f ,; .{ A 0 A C1J FY=36 KS\. (ASTM A-36) FOUR 1 /2"¢ ANCHOR BOLTS PER BASE PLATE 3 1/2" EMB., (SEE NOTE NO. 4) BASE PLATE DETAIL 0 ... N ' ro "' ' ro "' ' ro "' - ' / / ,/ALL N OTHER LEVELS \ V '/ / ~· 1 / r-{:I) st LEVEL I ' ' . I/ . . . • •? FRONT VIEW I I {)/ / I 'r I {)/ / 2" 'r I' I ~ ' I ;l {)/ / 'r I ~ ' {)/ \D / -.____ t=0.06" ,,., ~ ,,., Q Q G 2CU815 1 4 PIN CONNECTOR v io o1 10~01 10~0I lo or = io 01 = ~ Cc ~ I " ~ " " 4~ " "' "° 6 ' "t§ ~ " ~ " ' " cc , cc , " > " ,> " ' ' , ' " " " -A "' - " 6 6 " " , " ' 6 BASE PL. & SLAB CONNECTION ' <{) N <{) N ' <{) N ' <{) N ' \{) N <{) N ' .--(1) I---...__ ,---( 6 ) / , __ _, "'.,[_,__.-., _ __.....___, . " . SIDE VIEW ' r 2 7 '> 7 /16°01<! RIVET ~ ASTM A354-79 / I@ I © I~ I@ I ll p ' - N ' N ' N ' -~ lYP ;,----.---,~--- " 1/8 ' (X) ~- / TH°K=3/ 16"J BEAM WELD DETAIL 4 PIN GENERAL CONFIGURATION 3 8 t=.07" ' <D N j, 1 3/16" j, "z" BEAM CONN. NOTES: 7 /16"0 RIVET ASTM A354-79 1-DESIGN OF STEEL STORAGE RACKS AS SHOWN BY THESE DRAWINGS AND CALCULATIONS ARE IN COMPLIANCE WITH THE REQUIREMENTS OF THE UNIFORM BUILDING CODE 1997 EDITION ©· © ' - N , N N ' - 2-STEEL FOR ALL SHAPES FY=50 KSI. ASTM A570-85 GR.50 (EXCEPT AS NOTED) 3-CONCRETE SLAB 5" THICK 2000 PSI. SOIL BEARING CAPACITY 1000 PSF 4-ANCHORS WEDGE TYPE HILTI KWIK-II ICBO #4627, RAMSET REDHEAD ICBO #1372 OR SIMPSON ICBO #3631, (NO SPECIAL INSPECTION REQUIRED) 5-STORAGE RACK CAPACITY 1 000 # / LEVEL 6-ALL RACK INSTALLATIONS AND RACKS MANUFACTURED IN CONFORMITY WITH THIS STANDARD SHALL DISPLAY IN ONE OR MORE CONSPICUOUS LOCATIONS A PERMANENT PLAQUE EACH NOT LESS THAN 50 SQUARE INCHES IN AREA SHOWING THE MAXIMUM PERMISSIBLE UNIT LOAD OF NOTE NO. 6 ?-STORAGE RACKS SHALL BE INSTALLED WITH A MAXIMUM TOLERANCE FROM THE VERTICAL OF 1" IN 1 o· -0" OF HEIGHT 2 3/4" , ... \=.09" .____ -,,., ' ro U81 4 COLUMN SECTION 5 9 10 REV. DATE REVISION RACK DESIGN AND ENGINEERING 3786 LA CRESCENTA AVE. 204 GLENDALE CA. 91208 SCALE: NONE DRAWN BY:~ DATE: 1-17-02 PROJECT: ISIS PHARMACEUTICAL 1891 RUTHERFORD RD., CARLSBAD, CA. JOB NO. SHEET NO. "MECALUX" RACK DETAILS RD-6482 1 OF 1 • • t=.06" SEC. A-A HORIZONTAL & DIAGONAL BRACING 0 5/16"¢ GR. 5 ,, BOLT , ~- > -" SEC. B-B BRACE TO COLUMN CONN. . ~~~--<-TYP / /j' 1/8 @ :: I \ ",-, ------------------,1",1.... '\ TH'K=3/8" _\ FY=36 KSI. (ASTM A-36) FOUR 1/2"11) ANCHOR BOLTS PER BASE PLATE 3 1 /2" EMB., (SEE NOTE NO. 4) BASE PLATE DETAIL 0 " N re-·-.. c:= l~=======tJF== , ro "' , ro "' ro t') r----- ro "' ·re--- ro " ,--(41 TYP. / _.,, ./ .ALL OTHER LEVELS 11======:t:M:::;:= \ ·--® /./ I st LEVEL FRONT VIEW I I I I I I;, I I I I 1 4 PIN CONNECTOR ~.., 0 'CO • "' ~ ' ~ > • • • 0 • -,. • • • l(J-1 OI 1CJ~01 IQ~OI io IQ oi ~) • 0 A ' • • • .., • , <O I"' r " " Li F->"' . -§ • ,i 0 , • • t=0.06" 2CU815 • • > 0 • • 6 BASE PL. & SLAB CONNECTION ~-. . ,-7 1 / I , -/ , ti) r N / ti) N , "' N , "' N , "' N , ti) r:-N . -\ 6) --._,j , ro . " SIDE VIEW 2 7 > 7 /16"¢ RIVET - ASTM A354-79 I @ I@ I~ \$ 1V I/fl , - , N N , N , - ' TYP .;,----,--,---"-- • 1/8 ro I TH'K=3/16'._/ BEAM WELD DETAIL 4 PIN J GENERAL CONFIGURATION 3 8 , <O N J 1 3/16" J © © TYP 1/8 7 /16"11) RIVET ASTM A354-79 "z" BEAM CONN. NOTES: 1-DESIGN OF STEEL STORAGE RACKS AS SHOWN BY THESE DRAWINGS AND CALCULATIONS ARE IN COMPLIANCE WITH THE REQUIREMENTS OF THE UNIFORM BUILDING CODE 1997 EDITION 2-STEEL FOR ALL SHAPES FY=50 KSI. ASTM A570-85 GR.50 (EXCEPT AS NOTED) 3-CONCRETE SLAB 5" THICK 2000 PSI. SOIL BEARING CAPACITY 1000 PSF , - , N , N , N , - 4-ANCHORS WEDGE TYPE HILT! KWIK-II ICBO #4627, RAMSET REDHEAD ICBO # 1372 OR SIMPSON ICBO #3631, (NO SPECIAL INSPECTION REQUIRED) 5-STORAGE RACK CAPACITY 1000 # / LEVEL 6-ALL RACK INSTALLATIONS AND RACKS MANUFACTURED IN CONFORMITY WITH THIS STANDARD SHALL DISPLAY IN ONE OR MORE CONSPICUOUS LOCATIONS A PERMANENT PLAQUE EACH NOT LESS THAN 50 SQUARE INCHES IN AREA SHOWING THE MAXIMUM PERMISSIBLE UNIT LOAD OF NOTE NO. 6 7-STORAGE RACKS SHALL BE INSTALLED WITH A MAXIMUM TOLERANCE FROM THE VERTICAL OF I " IN 10' -0" OF HEIGHT , ro 4 9 2 3/4" t=.09" U81 COLUMN SECTION 5 1 0 REV. DATE REVISION RACK DESIGN AND ENGINEERING 3786 LA CRESCENTA AVE. 204 GLENDALE CA. 91208 SCALE: NONE DRAWN BY:~ DATE: 1 -17-02 PROJECT: !SIS PHARMACEUTICAL 1891 RUTHERFORD RD., CARLSBAD, CA. "MECALUX" RACK DETAILS JOB NO. RD-6482 SHEET NO. 1 OF 1