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Home My WebLink About2282 FARADAY AVE; ; CB081088; PermitCity of Carlsbad 10-03-2008 1635 Faraday Av Carlsbad, CA 92008 Commercial/Industrial Permit Permit No: CB081088 Building Inspection Request Line (760) 602-2725 Job Address: 2282 FARADAY AV CBAD Permit Type: Tl· . Sub Type: COMM Parcel No: Lot#: 0 Status: Valuation: Occupancy Group: 2120614600 $975,731.00 Construction Type: 58 Reference #: Applied: Entered By: Project Title: Applicant: BLEVINS LEAF 1255 PHILLIPS ST VISTA CA 92083 619-944-4107 Building Permit ISIS --1500 SF INTERIOR RENOVATION.LAB TO LAB Add'I Building Permit Fee Plan Check Add'I Plan Check Fee Plan Check Discount Strong Motion Fee Park Fee LFM Fee Bridge Fee BTD#2 Fee BTD#3 Fee Renewal Fee Add'I Renewal Fee Other Building Fee Pot. Water Con. Fee Meter Size Add'I Pot. Water Con. Fee Reel. Water Con. Fee $3,296.85 $0.00 $2,142.95 $0.00 $0.00 $204.90 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 Plan Approved: Issued: Inspect .A.rea: Plan Check#: Owner: BMR-2282 FARADAY AVENUE LLC C/O PARADIGM TAX GROUP 3645 RUFFIN RD #310 SAN DIEGO CA 92123 Meter Size Add'I Reel. Water Con. Fee Meter Fee SDCWAFee CFD Payoff Fee PFF (3105540) PFF (4305540) License Tax (3104193) License Tax (4304193) Traffic Impact Fee (3105541) Traffic Impact Fee (4305511) PLUMBING TOTAL ELECTRICAL TOTAL MECHANICAL TOTAL Master Drainage Fee Sewer Fee Redev Parking Fee Additional Fees HMP Fee ISSUED 06/09/2008 KG 10/03/2008 10/03/2008 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 ?? TOTAL PERMIT FEES $5,644.70 Total Fees: $5,644.70 Total Payments To Date: $5,644.70 Balance Due: $0.00 . Inspector:~ FINAL APPROVAL Date: q--/q/ o5' ~]}~}~-~~~~~~~~~ _ATTACHED Clearance: ------ NOTICE: Please take NOTICE that approval of your project includes the 'Imposition" of fees, dedications, reservations, or other exactions hereafter collectively referred to as "fees/exactions." You have 90 days from the date this permit was issued to protest imposition of these fee~/exactions. If you protest them, you must follow the protest procedures set forth in Government Code Section 66020(a), and file the protest and any other required' information with the City Manager for processing in accordance with Carlsbad Municipal Code Section 3.32.030. Failure to timely follow that procedure will bn~ any subsequent legal action to attack, review, set aside, void, or annul their imposition. You are hereby FURTHER NOTIFIED that your right to protest the specified fees/exactions DOES NOT APPLY to water ;;nd sewer connection fees and capacity changes, nor planning, zoning, grading or other similar application processing or service fees in connection with this project. NOR DOES IT APPLY to any fees/exactions of which vou have oreviouslv been aiven a NOTICE similar to this or as to which the statute of limitations has previously otherwise exoired. City of Carlsbad 1635 Faraday Ave., Carlsbad, CA 92008 760-602-2717 / 2718 / 2719 Fax: 760-602-8558 Building Permit Application DESCRIPTION OF WORK: tJ Plan Check No Est. Value 5::) 50 0 OCC. GROUP PRO~SE GARAGE (SF) AIR CONDITIONING YES D NOD FIRE SPRINKLERS YES D NOD ZIP EMAIL 7-v/ CITY STATE ZIP STATE <?,4- PHONE FAX PONE FAX Lr<c>399 292..S- EMAIL ARCHiDESIGNER NAME & ADDRESS STATELIC.# CITY BUS. LIC.# flee. 7031.S Business and Professions Code: Any City or Countr, which requires a permit to construe~ al% improve, demolish or reP,air any tructure1 prior to ill i11uance, aho requires the applicant lor such permit to file a signed statement that he is jce~sed .Jl0urmnt to the provisions ol the Contractor's License Law {Chapter 9, commending with Section ,000 of DJYision 3 of the Business and Proressions Code} or that he is exempt thereliinn, and the bai1s for the allegtd exemption. Any violation of ,ect1on 7131.S by any applicant for a permit sub~ctl the applicant to a civil penalty ol not more than five hundred dollm {$500}). . . Workers' Compensation Declarallon: I hereby affirm under penalty of perjury one of the following declarations: D I have and will maintain a certificate of consent to self-Insure for workers' compensati~n as provided by Section 3700 of the Labor Code, for the performance of the work for which this permit is issued. D I have and will maintain work rs' compensation, as required by Section 3700 of the Labor Code, for the performance of the work for which this permit is issued. My workers' compens tion insu ance c rrier and policy number are: Insurance Co. 611(:r F t;Je D e .+u Policy No)( s::+u.,'cc:.... I J O b q, 0 Expiration Dal 0;?. 3 D. This seclion need not be completed if the permit is for one hundred dollars ($100) or less. · D Certificate of Exemption: I certify that in the performance of the work for which this permit is issued, I shall not employ any person in any manner so as to become subject to the Workers' Compensation Laws of California. WARNING: Failure to secure workers' compensation coverage Is unlawful, and shall subject an employer to criminal penalties and civil fines up to one hundred thousand dollars (&100,000), in addition to the cost of compensation, damages as vlde for)1 Section 3706 of the Labor code, Interest and attorney's fees. ',Ii$ CONTRACTOR SIGNATURE f/lf t/.P.---=== . I hereby affirm that I am exempt from Contractor's License Law for the following reason: Cl I, as owner of the property or my employees wilh wages as their sole compensation, will do lhe work and the structure is not intended or offered for sale (Sec. 7044, Business and Professions Code: The Contractor's License Law does not apply to an owner of property who builds or improves thereon, and who does such work himself or through his own employees, provided that such improvemenls are not intended or offered for sale. If, however, the building or improvement is sold within one year of completion, the owner-builder will have the burden of proving that he did not build or improve for the purpose of sale). Cl I, as owner of the properly, am exclusively conlracting with licensed contractors to conslruct the project (Sec. 7044, Business and Professions Code: The Contractor's License Law does not apply lo an owner of property who builds or improves thereon, and contracts for such projects with conlraclor(s) licensed pursuant to the Contraclor's License Law). Cl I am exempt under Seclion ____ Business and Professions Code for !his reason: 1. I personally plan to provide the major labor and materials for construclion of the proposed property improvement. Cl Yes Cl No 2. I (have I have not) signed an applicalion for a building permit for the proposed work. 3. I have contracted with lhe following person (firm) to provide the proposed conslruclion (include name address /phone/ contractors' license number): 4. I plan to provide portions of the work, but I have hired the following person to coordinate, supervise and provide the major work (include name I address/ phone/ contractors' license number): 5. I will provide some of the work, but I have contracted (hired) the following persons to provide the work indicaled (include name/ address / phone / type of work): RS PROPERTY OWNER SIGNATURE DATE Is the applicant or future building occupant required to submit a business plan, acutely hazardous materials registration form or risk management and prevention program under Sections 25505, 25533 or 25534 of the Presley-Tanner Hazardous Substance Account Act? 0 Yes O No Is the applicant or future building occupant required to oblain a permit from the air pollution control district or air qualily management district? Cl Yes Cl No Is the facility to be conslructed within 1,000feet of the outer boundary of a school site? D Yes D No IF ANY OF THE ANSWERS ARE YES, A FINAL CERTIFICATE OF OCCUPANCY MAY NOT BE ISSUED UNLESS THE APPLICANT HAS MET OR IS MEETING THE REQUIREMENTS OF THE OFFICE OF EMERGENCY SERVICES AND THE AIR POLLUTION CONTROL DISTRICT. I certify thatl have read the application and state that the above Information Is cxmectand that the information on the plans Is accurate. I agree to comply with all Clfy ortflnances and State laws relating to building construction. ~hereby authorize representalive of the City of Carlsbad to enter upon the above mentioned property for inspection pul])oses. I ALSO AGREE TO SAVE, INDEMNIFY AND KEEP HARMLESS THE CITY OF CARLSBAD AGAINST ALL LIABILITIES, JUDGMENTS, COSTS AND EXPENSES WHICH W..Y IN ANYWAY ACCRUE AGAINST SAID CITY IN CONSEQUENCE OF THE GRANTING OF THIS PERMIT. OSHA: An OSHA pelTlllt is required for excava ·ons over 5'0' deep~d demolition or construction of structures over 3 stories in height. EXPIRATION: Every permit issued by the B · i ·a1 nder rovisions of this Code shall expire by Hmitatiori and become null and void if the building or work authorized by such permit is not comr]lenced within 180 days from the date of such permit or if. e ing • b · · spended or abandoned at any time after the WOik is commenced for a period of]._~~ (Section 106.4.4 Uniform Building Code). ,,1$ APPLICANT'S SIGNATUR DATE ~~q -tiff Cltv 01 Carlsbad · Final Building Inspection Dept: Building Engineering Planning CMWD St Lite \E.IBe Plan Check #: Permit#: CB081088 Project Name: ISIS --1500 SF INTERIOR RENOVATION,LAB TO LAB Address: Contact Person: Sewer Dist: 2282 FARADAY AV RONNIE CA Phone: 6197086363 Water Dist: CA Date: Permit Type: Sub Type: Lot: 0 05/06/2009 Tl COMM .......................................................................................................................................................... Inspected {J ?r.A~ Date $ft.ff By: rnspected: · Approved: Disapproved: __ 7 Inspected Date By: Inspected: Approved: Disapproved: __ Inspected Date By: Inspected: Approved: Disapproved: __ Comments: ------------------------------ .. - City of Carlsbad Bldg Inspection Request For: 05/06/2009 Permit# CB081088 Inspector Assignment: TP --- Title: ISIS --1500 SF INTERIOR Description: RENOVATION,LAB TO LAB Type:TI Job Address: Sub Type: COMM 2282 FARADAY AV Phone: 263 Suite: Lot: 0 Location: Inspector: OWNER BMR-2282 FARADAY AVENUE LLC Owner: BMR-2282 FARADAY AVENUE LLC Remarks: Total Time: Requested By: RONNIE Entered By: CHRISTINE CD 19 29 39 49 Description Act Comments Final Structural AP _________ _ Final Plumbing Final Electrical Final Mechanical f--- Comments/Notices/Holds Associated PCRs/CVs Original PC# PCR02200 ISSUED PCR02223 ISSUED PCR02246 ISSUED ISIS PHARMACEUTICALS; INTERIOR REMODEL, TRANSMITTAL DATED 7/15/02 ISIS PHARMACUTICALS; STRUCTURAL REVISIONS ISIS PHARM-AS-BUILT REVISIONS; AS PER DELTA 6 PCR02247 ISSUED ISIS PHARM-STRUCTURAL REVISION; AS PER DELTA 3 PCR08064 ISSUED ISIS-REGRADE TO ACCOMMODATE; CONTAINMENT OF FOAM DISCHARGE AND D PCR08105 PENDING ISIS: DEFERR:DET AILS ON ATI ACH; MENT OF SCRUBBER TO PLATFORM os ·D <? y Y PCR08106 ISSUED ISIS: REVISE TANK PAD;Or~l/f . PCR08111 ISSUED ISIS-CMU FOUNDATION CHANGE; PAGES SI.0, Sl.1,S2.I 07'J;) / / y PCR08113 ISSUED ISIS: REVISION OF PAVED AREA; TO ACCOMODATE FIRE PROTECTION EQUIP. & R 077J // 4 PCR08120 ISSUED ISIS-CHANGE FRAMING AT ACCESS; OPENINGS 0'6 · '() fy y PCR08130 ISSUED ISIS-INTERIOR DOOR CHANGES&; EXTENDING REVISIONS IN TO AREA LAB #166 ( PCR99184 ISSUED ISIS PHARMCEUTICALS; ELECTRIC REVISIONS Inspection History Date Description Act lnsp Comments 01/15/2009 84 Rough Combo AP TP T-CEILING@ LAB 165 & CORR City of Carlsbad Bldg Inspection Request For: 05/06/2009 Permit# CB081088 Inspector Assignment: TP 01/06/2009 44 Rough/Ducts/Dampers AP TP BOILER B VENTS 01/06/2009 44 Rough/Ducts/Dampers AP TP RM 156 & ADJ CORR DUCTS, REG. 12/04/2008 23 Gas/Test/Repairs AP TP re-lol for 2 boflers 11/25/2008 17 Interior Lath/Drywall AP TP 11/20/2008 14 Frame/Steel/Bolting/Welding AP TP room 119 per rev. ASI # 2 11/20/2008 34 Rough Electric AP TP EsGil Corporation In <Partnersfiip witfi (jovernment for <Buifaing Safety DATE: 9/29/08 JURISDICTION: City of Carlsbad PLAN CHECK NO.: 081088 PROJECT ADDRESS: 2282 Faraday PROJECT NAME: Isis Pharmaceuticals T. I. SET: IV ~ANT ~ D PLAN REVIEWER D FILE D The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's building codes. 1:8:] The plans transmitted herewith will substantially comply with the jurisdiction's building codes when minor deficiencies identified below are resolved and checked by building department staff. D The plans transmitted herewith have significant deficiencies identified on the enclosed check list and should be corrected and resubmitted for a complete recheck. D The check list transmitted herewith is for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. D The applicant's copy of the check list is enclosed for the jurisdiction to forward to the applicant contact person. D The applicant's copy of the check list has been sent to: 1:8:] Esgil Corporation staff did not advise the applicant that the plan check has been completed. D Esgil Corporation staff did advise the applicant that the plan check has been completed. Person contacted: Telephone#: Date contacted: (by: ) Fax#: Mail Telephone Fax In Person 1:8:] REMARKS: 1 .. Please slip revised sheet A-105-3 and E2.1 (first floor riew power plan area 1) into city Ill set. (at building department) 2. City to field verify that the path of travel from the handicapped parking space to the remodel area and the bathrooms serving the remodel area comply with all the current disabled access requirements. 3. The construction value of the project has been revised. By: David Yao Enclosures: Esgil Corporation D GA D MB D EJ D PC 9/22 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (858) 560-1468 + Fax (858) 560-1576 EsGil Corporation In (['artners/i.ip wit/i. (Jovemment for (Bui{aing Safety DATE: 8/28/08 JURISDICTION: City of Carlsbad PLAN CHECK NO.: 081088 PROJECT ADDRESS: 2282 Faraday PROJECT NAME: Isis Pharmaceuticals T. I. SET: Ill ~T ~ D PLAN REVIEWER D FILE D The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's building codes. D The plans transmitted herewith will substantially comply with the jurisdiction's building codes when minor deficiencies identified below ar~ resolved and checked by building department staff. D The plans transmitted herewith have significant deficiencies identified on the enclosed check list and should be corrected and resubmitted for a complete recheck. fLI The check list transmitted herewith is for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. D The applicant's copy of the check list is enclosed for the jurisdiction to forward to the applicant contact perso'n. fLI The applicant's copy of the check list has been sent to: Leaf Blevines 1255 Phillips Street Vista, CA 92083 D Esgil Corporation staff did not advise the applicant that the plan check has been completed. fLI l;:sgil Corporation staff did advise the applicant that the plan check has been completed. Person contacted: _}e?!Jlveines Telephone#: 619-944-4107 Date contacted:/7..1f/Oqb~ Fax #: 760-477-6032 Mail VTelephone Fax/In Person fLI REMARKS: The construction value for the project has been revised. By: David Yao Enclosures: Esgil Corporation D GA D MB ~ EJ D PC 8/21 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (858) 560-1468 + Fax (858) 560-1576 · City 'of Carlsbad 081088 8/28/08 . RECHECK CORRECTION LIST JURISDICTION: City of Carlsbad PROJECT ADDRESS: 2282 Faraday DATE PLAN RECEIVED BY ESGIL CORPORATION: 8/21 REVIEWED BY: David Yao FOREWORD (PLEASE READ): PLAN CHECK NO.: 081088 SET: II DATE RECHECK COMPLETED: 8/28/08 This plan review is limited. to the technical requirements contained in the Building Code, Plumbing Code, Mechanical Code, Electrical Code and state laws regulating energy conservation, noise attenuation and disabled access. This plan review is based on regulations enforced by the Building Department. You may have other corrections based on laws and ordinances enforced by the Planning Department, Engineering Department or other departments. The following items listed need clarification, modification or change. All items must be satisfied before the plans will be in conformance with the cited codes and regulations. The approval of the plans does not permit the violation of any state, county or city law. A. To facilitate rechecking, please identify, next to each item, the sheet of the plans upon which each correction on this sheet has been made and return this sheet with the revised plans. B. The following items have not been resolved from the previous plan reviews. The original correction number has been given for your reference. In case you did not keep a copy of the prior correction list, we have enclosed those pages containing the outstanding corrections. Please contact me if you have any questions regarding these items. C. Please indicate here if any changes have been made to the plans that are not a result of corrections from this list. If there are other changes, please briefly describe them and where they are located on the plans. Have changes been made not resulting from this list? DYes DNo · City 1of Carlsbad 081088 8/28/08 No response was provided to Esgil Corp. Please make all corrections, as requested in the correction list. Submit three new complete sets of plans for commercial/industrial projects (two sets of plans for residential projects). For expeditious processing, corrected sets can be submitted in one of two ways: 1. Deliver all corrected sets of plans and calculations/reports directly to the City of Carlsbad Building Department, 1635 Faraday Ave., Carlsbad, CA 92008, (760) 602-2700. The City will route the plans to EsGil Corporation and the Carlsbad Planning, Engineering and Fire Departments. 2. Bring one corrected set of plans and calculations/reports to EsGil Corporation, 9320 Chesapeake Drive, Suite 208, San Diego, CA 92123, (858) 560-1468. Deliver all remaining sets of plans and calculations/reports directly to the City of Carlsbad Building Department for routing to their Planning, Engineering and Fire Departments. NOTE: Plans that are submitted directly to EsGil Corporation only will not be reviewed by the City Planning, Engineering and Fire Departments until review by EsGil Corporation is complete. DISABLED ACCESS REVIEW LIST DEPARTMENT OF STATE ARCHITECT TITLE 24 The following disabled access items are taken from the 2007 edition of California Building Code, Title 24. Per Section 109.1, all publicly and privately funded public accommodations and commercial facilities shall be accessible to persons with disabilities. NOTE: All Figures and Tables referenced in this checklist are printed in the California Building Code, Title 24. • REMODELS, ADDITIONS AND REPAIRS 1. When alterations, structural repairs or modifications or additions are made to an existing building, that building, or portion of the building affected, is required to comply with all of the requirements for new buildings, per Section 1134B.2. These requirements apply as follows: a) The area of specific alteration, repair or addition must comply as "new" construction. b) A primary entrance to the building and the primary path of travel to the altered area, must be shown to comply with all accessibility features. c) Existing sanitary facilities that serve the remodeled area must be shown to comply with all accessibility f~atures. d) Existing drinking fountains (if any) must be shown to comply with all accessibility features. e) Existing public telephones (if any) must be shown to comply with all accessibility features. ~ City~of Carlsbad 081088 8/28/08 To speed up the review process, note on this list (or a copy) where each correction item has been addressed, i.e., plan sheet, note or detail number, calculation page, etc. Please indicate here if any changes have been made to the plans that are not a result of corrections from this list. If there are other changes, please briefly describe them and where they are located in the plans. Have changes been made to the plans not resulting from this correction list? Please indicate: D Yes D No The jurisdiction has contracted with Esgil Corporation located at 9320 Chesapeake Drive, Suite 208, San Diego, California 92123; telephone number of 858/560-1468, to perform the plan review for your project. If you have any questions regarding these plan review items, please contact David Yao at Esgil Corporation. Thank you. PLUMBING, MECHANICAL, ELECTRICAL, and ENERGY CORRECTIONS PLAN REVIEWER: Eric Jensen ARCHITECTURAL PME ITEMS ELECTRICAL (2005 NATIONAL ELECTRICAL CODE) 1. Sheet E 111 and E 112 (automation) have classified locations that are shown on the electrical floorplans. On the standard electrical plans reference any classified detail sheets that concern areas covered by this permit. Sheet E111 has classified locations described in rooms 133 & 150 that are not addressed on sheet E2. 1. Note: If you have any questions regarding this Electrical, Plumbing, Mechanical, and Energy plan review list please contact Eric Jensen at (858) 560-1468. To speed the review process, note on this list (or a copy) where the corrected items have been addressed on the plans. END EsGil Corporation In <Partnersliip witli qovernment for c.Buifaing Safety DATE: 8/13/08 D APPLICANT JURISDICTION: City of Carlsbad ~AN REVIEWER ~u~ D FILE PLAN CHECK NO.: 081088 SET: II PROJECT ADDRESS: 2282 Faraday PROJECT NAME: Isis Pharmaceuticals T. I. D D D D The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's building codes. The plans transmitted herewith will substantially comply with the jurisdiction's building codes when minor deficiencies identified below are resolved and checked by building department staff. The plans transmitted herewith have significant deficiencies identified on the enclosed check list and should be corrected and resubmitted for a complete recheck. The check list transmitted herewith is for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. The applicant's copy of the check list is enclosed for the jurisdiction to forward to the applicant contact person. The applicant's copy of the check list has been sent to: Leaf Blevines 1255 Phillips Street Vista, CA 92083 Esgil Corporation staff did not advise the applicant that the plan check has been completed. Esgil Corporation staff did advise the applicant that the plan check has been completed. Person contacted; )-eo/f f veines Date contactedf//3/0 (bY-4/13) MailV\elephone Fa~ In Person Telephone#: 619-944-4107 Fax #: 760-477-6032 REMARKS: The construction value for the project has been revised. By: David Yao Enclosures: Esgil Corporation 0 GA O MB IX] EJ O PC 8/7 9320 Chesapeake Drive, Suite 208 + San Diego, Califorp.ia 92123 + (858) 560-1468 + Fax (858) 560-1576 ' City of Carlsbad 081088 8/13/08 RECHECK CORRECTION LIST JURISDICTION: City of Carlsbad PROJECT ADDRESS: 2282 Faraday DATE PLAN RECEIVED BY ESGIL CORPORATION: 8/7 REVIEWED BY: David Yao FOREWORD (PLEASE READ): PLAN CHECK NO.: 081088 SET: II DATE RECHECK COMPLETED: 8/13/08 This plan review is limited to the technical requirements contained in the Building Code, Plumbing Code, Mechanical Code, Electrical Code and state laws regulating energy conservation, noise attenuation and disabled access. This plan review is based on regulations enforced by the Building Department. You may have other corrections based on laws and ordinances enforced by the Planning Department, Engineering Department or other departments. Ttie following items listed need clarification, modification or change. All items must be satisfied before the plans will be in conformance with the cited codes and regulations. The approval of the plans does not permit the violation of any state, county or city law. A. To facilitate rechecking, please identify, next to each item, the sheet of the plans upon which each correction on this sheet has been made and return this sheet with the revised plans. B. The following items have not been resolved from the previous plan reviews. The original correction number has been given for your reference. In case you did not keep a copy of the prior correction list, we have enclosed those pages containing the outstanding corrections. Please contact me if you have any questions regarding these items. C. Please indicate here if any changes have been made to the plans that are not a result of corrections from this list. If there are other changes, please briefly describe them and where they are located on the plans. Have changes been made not resulting from this list? DYes DNo City of Carlsbad 081088 8/13/08 Please make all corrections, as requested in the correction list. Submit three new complete sets of plans for commercial/industrial projects (two sets of plans for residential projects). For expeditious processing, corrected sets can be submitted in one of two ways: 1. Deliver all corrected sets of plans and calculations/reports directly to the City of Carlsbad Building Department, 1635 Faraday Ave., Carlsbad, CA 92008, (760) 602-2700. The City will route the plans to EsGil Corporation and the Carlsbad Planning, Engineering and Fire Departments. 2. Bring one corrected set of plans and calculations/reports to EsGil Corporation, 9320 Chesapeake Drive, Suite 208, San Diego, CA 92123, (858) 560-1468. Deliver all remaining sets of plans and calculations/reports directly to the City of Carlsbad Building Department for routing to their Planning, Engineering and Fire Departments. NOTE: Plans that are submitted directly to EsGil Corporation only will not be reviewed by the City Planning, Engineering and Fire Departments until review by EsGil Corporation is complete. DISABLED ACCESS REVIEW LIST DEPARTMENT OF STATE ARCHITECT TITLE 24 The following disabled access items are taken from the 2007 edition of California Building Code, Title 24. Per Section 109.1, all publicly and privately funded public accommodations and commercial facilities shall be accessible to persons with disabilities. NOTE: All Figures and Tables referenced in this checklist are printed in the California Building Code, Title 24. • REMODELS, ADDITIONS AND REPAIRS 1. When alterations, structural repairs or modifications or additions are made to an existing building, that building, or portion of the building affected, is required to comply with all of the requirements for new buildings, per Section 1134B.2. These requirements apply as follows: a) The area of specific alteration, repair or addition must comply as "new" construction. b) A primary entrance to the building and the primary path of travel to the altered area, must be shown to comply with all accessibility features. c) Existing sanitary facilities that serve the remodeled area must be shown to comply with all accessibility features. d) Existing drinking fountains (if any) must be shown to comply with all accessibility features. e) Existing public telephones (if any) must be shown to comply with all accessibility features. To speed up the review process, note on this list (or a copy) where each correction item has been addressed, i.e., plan sheet, note or detail number, calculation page, etc. City of Carlsbad 081088 8/13/08 Please indicate here if any changes have been made to the plans that are not a result of corrections from this list. If there are other changes, please briefly describe them and where they are located in the plans. Have changes been made to the plans not resulting from this correction list? Please indicate: D Yes D No The jurisdiction has contracted with Esgil Corporation located at 9320 Chesapeake Drive, Suite 208, San Diego, California 92123; telephone number of 858/560-1468, to perform the plan review for your project. If you have any questions regarding these plan review items, please contact David Yao at Esgil Corporation. Thank you. PLUMBING, MECHANICAL, ELECTRICAL, and ENERGY CORRECTIONS PLAN REVIEWER: Eric Jensen ARCHITECTURAL PME ITEMS ELECTRICAL (2005 NATIONAL ELECTRICAL CODE) 1. Sheet E111 and E112 (automation) have classified locations that are shown on the electrical floorplans. On the standard electrical plans reference any classified detail sheets that concern areas covered by this permit. Sheet E111 has classified locations described in rooms 133 & 150 that are not addressed on sheet E2. 1. Note: If you have any questions regarding this Electrical, Plumbing, Mechanical, and Energy plan review list please contact Eric Jensen at (858) 560-1468. To speed the review process, note on this list (or a copy) where the corrected items have been addressed on the plans. END l l • ' DATE: 08/13/2008 JURISDICTION: Carlsbad PLAN CHECK NO.: 08-0286 EsGil Corporation In (Partners nip witfi qovernment for (]Jui(aing Safety SET:VI PROJECT ADDRESS: 1415 Forest Ave. Cl APPLICANT Cl JURIS. Cl PLAN REVIEWER Cl FILE PROJECT NAME: Add D9rmers and Stairs at Attic for the Seiderman Residence D The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's building codes. D The plans transmitted herewith will substantially comply with the jurisdiction's building codes when minor deficiencies identified below are resolved and checked by building department staff. D The plans transmitted herewith have significant deficiencies identified on the enclosed check list and should be corrected and resubmitted for a complete recheck. ~ The check list transmitted herewith is for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. D The applicant's copy of the check list is enclosed for the jurisdiction to forward to the applicant contact person. ~ The applicant's copy of the check list has been sent to: Brian and Joyce Seiderman 1415 Forest Ave., Carlsbad, CA 92008 D Esgil Corporation staff did not advise the applicant that the plan check has been completed. ~ Esgil Corporation staff did advise the applicant that the plan check has been completed. Person contacte~ ~9~r Joyce Seiderman Telephone#: 760 729-0551 Date contactedP//.3/0. (byJ..'6) Fax #: SAME MaiVTelephone D REMARKS: FaxV In Person By: Aaron Goodman Esgil Corporation D GA D MB D EJ D PC Enclosures: 08/08/2008 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (858) 560-1468 + Fax (858) 560-1576 ' · Carlsbad 08:..0286 08/13/2008 • PLANS 1. Please make all corrections on the original tracings, as requested in the correction list. Submit two sets of plans for residential projects. For expeditious processing, corrected sets can be submitted in one of two ways: 1. Deliver all corrected sets of plans and calculations/reports directly to the City of Carlsbad Building Department, 1635 Faraday Ave., Carlsbad, CA 92008, (760) 602-2700. The City will route the plans to EsGil Corporation and the Carlsbad Planning, Engineering and Fire Departments. 2. Bring one corrected set of plans and calculations/reports to EsGil Corporation, 9320 Chesapeake Drive, Suite 208, San Diego, CA 92123, (858) 560-1468. Deliver all remaining sets of plans and calculations/reports directly to the City of Carlsbad Building Department for routing to their Planning, Engineering and Fire Departments. · 4. REMINDER: Final Plans, specifications and calculations shall be signed and sealed by the California state licensed engineer or architect responsible for their preparation. Specify expiration date of license. (California Business and Professions Code). This will be verified on final sets. The designer listed on the title block needs to be the one signing. The last set of plans were signed. NO PENCIL OR PENNED IN CORRECTIONS ARE ALLOWED ON THE FINAL SET. THIS SET HAD SEVERAL PENCILLED IN CORRECTIONS. 7. 08/13/2008: The stairway to the storage attic is not correct. Please review all of Section 1009 and correct. In a meeting with Brian Seiderman it was mentioned that the lightly dotted in door at the bottom of the stairs is intended to remain. I believe the dotted in nature of the drawing suggests that his door was to be removed. If it is to remain, the door shall not swing over a step per section 1008.1.4. Please correct. 06/30/2008: No Response. 06/19/2008: No Response. Provide stairway and landing details. Section 1009. Stairway must comply with a) and b) below unless waived by the building official. Framing plan and support details are necessary and still required. a) Maximum rise is 7-3/4" and minimum run is 10". Unable to find this specified. b) A nosing not less than .75 inch but not more than 1.25 inches shall be provided on stairways with solid risers where the tread depth is less than 11 inches. Unable to find this specified. c) Provide structural details. Please provide a stair framing plan and show where all stringers are supported. · · , · Carlsbad 08-0286 08/13/2008 8. 08/13/2008: The stairway to the storage attic is not correct. Please review all stair requirements of Section 1009 and correct the plans. 06/30/2008: No Response. 06/19/2008: No Response. Provide details of wfnding stairway complying with Section 1009.3: All winding treads must comply with the following. Response indicated they comply as shown, but they do not. The treads come to a point (O") where they need to be a minimum of 6" at the narrowest point and a minimum of 10" at a point 12" from the narrowest end. Winding treads must comply unless waived by the Building Official. d). Minimum tread is 6 inches at any point and minimum 10 inches at a point 12 inches from where the treads are narrowest. END OF REVIEW To speed up the review process, note on this list (or a copy) where each correction item has been addressed, i.e., plan sheet, note or detail number, calculation page, etc. · Have changes been made to the plans not resulting from this correction list? Please indicate: Yes D No D The jurisdiction has contracted with Esgil Corporation located at 9320 Chesapeake Drive, Suite 208, San Diego, California 92123; telephone number of 858/560-1468, to perform the plan review for your project. If you have any questions regarding these plan review items, please contact Aaron Goodman at Esgil Corporation. Thank you EsGil Corporation In <.Partnersliip witli government for (}3uiCtfing Safety DATE: 6/20/08 JURISDICTION: City of Carlsbad PLAN CHECK NO.: 081088 PROJECT ADDRESS: 2282 Faraday PROJECT NAME: Isis Pharmaceuticals T. I. SET:I D APPLICANT ANREVIEWER ~ D FILE D The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's building codes. D The plans transmitted herewith will substantially comply with the jurisdiction's building codes when minor deficiencies identified below are resolved and checked by building department staff. D The plans transmitted herewith have significant deficiencies identified on the enclosed check list and should be corrected and resubmitted for a complete recheck. cg] The check list transmitted herewith is for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. D The applicant's copy of the check list is enclosed for the jurisdiction to forward to the applicant contact person. ~ The applicant's copy of the check list has been sent to: Leaf Blevines 1255 Phillips Street Vista, CA 92083 D Esgil Corporation staff did not advise the applicant that the plan check has been completed. ~ Esgil Corporation staff did advise the applicant that the plan check has been completed. Person contacted: Leaf Blveines Telephone#: 619-944-4107 Date contacted:cPA,3/61 r(~ Fax #: 760-477-6032 Mai!Vrelephone FaV In Person D REMARKS: By: David Yao Enclosures: Esgil Corporation D GA D MB [g] EJ D PC 6/12 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (858) 560-1468 + Fax (858) 560-1576 City of Carlsbad 081088 6/20/08 PLAN REVIEW CORRECTION LIST TENANT IMPROVEMENTS PLAN CHECK NO.: 081088 OCCUPANCY: B/H2,H3,H7 TYPE OF CONSTRUCTION: V-N ALLOWABLE FLOOR AREA: SPRINKLERS?: Y REMARKS: DATE PLANS RECEIVED BY JURISDICTION: DATE INITIAL PLAN REVIEW COMPLETED: 6/20/08 FOREWORD (PLEASE READ): JURISDICTION: City of Carlsbad USE: office/labs ACTUAL AREA: 34340 sf STORIES: 2 HEIGHT: OCCUPANT LOAD: DA TE PLANS RECEIVED BY ESGIL CORPORATION: 6/12 PLAN REVIEWER: David Yao This plan review is limited to the technical requirements contained in the International Building Code, Uniform Plumbing Code, Uniform Mechanical Code, National Electrical Code and state laws regulating energy conservation, noise attenuation and access for the disabled. This plan review is based on regulations enforced by the Building Department. You may have other corrections based on laws and ordinances enforced by the Planning Department, Engineering Department, Fire Department or other departments. Clearance from those departments may be required prior to the issuance of a building permit. Code sections cited are based on the 2007 CBC, which adopts th~ 2006 IBC. The following items listed need clarification, modification or change. All items must be satisfied before the plans will be in conformance with the cited codes ar:id regulations. Per Sec. 105.4 of the 2006 International Building Code, the approval of the plans does not permit the violation of any state, county or city law. To speed up the recheck process, please note on this list (or a copy) where each correction item has been addressed, i.e., plan sheet number, specification section, etc. Be sure to enclose the marked up list when you submit the revised plans. . City of Carlsbad 081088 6/20/08 . Please make all corrections, as requested in the correction list. Submit three new complete sets of plans for commercial/industrial projects (two sets of plans for residential projects). For expeditious processing, corrected sets can be submitted in one of two ways: 1. Deliver all corrected sets of plans and calculations/reports directly to the City of Carlsbad Building Department, 1635 Faraday Ave., Carlsbad, CA 92008, (760) 602-2700. The City will route the plans to EsGil Corporation and the Carlsbad Planning, Engineering and Fire Departments. 2. Bring one corrected set of plans and calculations/reports to EsGil Corporation, 9320 Chesapeake Drive, Suite 208, San Diego, CA 92123, (858) 560-1468. Deliver all remaining sets of plans and calculations/reports directly to the City of Carlsbad Building Department for routing to their Planning, Engineering and Fire Departments. NOTE: Plans that are submitted directly to EsGil Corporation only will not be reviewed by the City Planning, Engineering and Fire Departments until review by EsGil Corporation is complete. 1. Keynote 4 on sheet A-401-4.2 shows door 117B is 60 minutes. The door schedule on A-601 shows door 117B 20 minutes. Please clarify. 2. Sheet A-401-4.2 shows door 165A is 20 minutes. Door schedule on sheet A-601 did not show door 165A. Please check. 3. IBC req·uires the Building Official to determine the total value of all construction work proposed under this permit. The value shall include all finish work, painting, roofing, electrical, plumbing, heating, air conditioning, elevator, fire extinguishing systems and any other permanent equipment. Please provide the designer's or contractor's construction cost estimate of all work proposed. 4. Please refer to the following corrections for electrical and mechanical items. DISABLED ACCESS REVIEW LIST DEPARTMENT OF STATE ARCHITECT TITLE 24 The following disabled access items are taken from the 2007 edition of California Building Code, Title 24. Per Section 109.1, all publicly and privately funded public accommodations and commercial facilities shall be accessible to persons with disabilities. NOTE: All Figures and Tables referenced in this checklist are printed in the California Building Code, Title 24. • REMODELS, ADDITIONS AND REPAIRS . City of Carlsbad 081088 6/20/08 . 1. When alterations, structural repairs or modifications or additions are made to an existing building, that building, or portion of the building affected, is required to comply with all of the requirements for new buildings, per Section 1134B.2. These requirements apply as follows: 5. 6. a) The area of specific alteration, repair or addition must comply as "new" construction. b) c) A primary entrance to the building and the primary path of travel to the altered area, must be shown to comply with all accessibility features. Existing sanitary facilities that serve the remodeled area must be shown to comply with all accessibility features. d) Existing drinking fountains (if any) must be shown to comply with all accessibility features. e) Existing public telephones (if any) must be shown to comply with all accessibility features. To speed up the review process, note on this list (or a copy) where each correction item has been addressed, i.e., plan sheet, note or detail number, calculation page, etc. Please indicate here if any changes have been made to the plans that are not a result of corrections from this list. If there are other changes, please briefly describe them and where they are located in the plans. Have changes been made to the plans not resulting from this correction list? Please indicate: D Yes D No 7. The jurisdiction has contracted with Esgil Corporation located at 9320 Chesapeake Drive, Suite 208, San Diego, California 92123; telephone number of 858/560-1468, to perform the plan review for your project. If you have any questions regarding these plan review items, please contact David Yao at Esgil Corporation. Thank you. City of Carlsbad 081088 6/20/08 PLUMBING, MECHANICAL, ELECTRICAL, and ENERGY CORRECTIONS PLAN REVIEWER: Eric Jensen ARCHITECTURAL PME ITEMS 1. Room 122 has "future boilers" (2) shown, (1) installed on the electrical, and no specifics on the mechanical or plumbing? Address the status of the boiler(s) with this permit. 2. There is a set of prints attached with the set of plans labeled: Automation and expansion project". Are the mechanical and electrical plans a summary of the permittable changes shown in the automation plans or are the automation plans in addition to the mechanical and electrical plans? For example: Sheet E2.3, column lines 2/A 1 has no new electrical but on the automation plans a new vapor recovery system is installed. Sheet E112 (automation) has an area (145) that references another electrical sheet (E103) that has electrical improvements on the standard (nonautomation) set. ELECTRICAL (2005 NATIONAL ELECTRICAL CODE) 3. The electrical redesign for area 146 is missing (sheet E2.2). Please include with the electrical plans and describe any classified locations in this area. 4. Area 151 has an expanded fume hood: Describe the location of the "up and down" crane control and its' relative location to any classified locations adjacent to the fume hood.- 5. Sheet E111 and E112 (automation) have classified locations that are shown on the electrical floorplans. On the standard electrical plans reference any classified detail sheets that concern areas covered by this permit. PLUMBING (2006 UNIFORM PLUMBING CODE) • No plumbing plans submitted. If any plumbing is to be covered by this permit, please include with the next submittal. MECHANICAL (2006 UNIFORM MECHANICAL CODE) 6. Room 165 is designed as an occupancy separation, provide damper protection where required. (SFD@ wall lines). 7. Corridor 125 is a rated corridor. Provide SFD damper protection so as to maintain the fire separation rating of the corridor. Note: If you have any questions regarding this Electrical, Plumbing, Mechanical, and Energy plan review list please contact Eric Jensen at (858) 560-1468. To speed the review process, note on this list (or a copy) where the corrected items have been addressed on the plans. END ~ , City of Carlsbad 081088 6/20/08 VALUATION AND PLAN CHECK FEE JURISDICTION: City of Carlsbad PREPARED BY: David Yao PLAN CHECK NO.: 081088 DATE: 6/20/08 BUILDING ADDRESS: 2282 Faraday BUILDING OCCUPANCY: BUILDING AREA Valuation PORTION ( Sq. Ft.) Multiplier T. I. remodel Air Conditioning Fire Sprinklers TOTAL VALUE Jurisdiction Code cb By Ordinance Bldg. Permit Fee by Ordinance J ..-j Plan Check Fee by Ordinance I • I Type of Review: Complete Review D Other TYPE OF CONSTRUCTION: Reg. VALUE Mod. per city D Structural Only D Repetitive Fee 3 Repeats 0 Hourly .__ ___ __.I Hour* Esgil Plan Review Fee Comments: ($) 52,500 52,500 -' $398.851 $259.251 $223.361 Sheet 1 of 1 macvalue.doc .. •L:ff'I , ?~Y -~ C tj BED ~ARCH!TECTS Wednesday, September 17, 2008 Mr. Mike Peterson, Plans Examiner· City of Carlsbad, California RE: 2282 Faraday, Isis Expansion and Alteration Project, Plan Check No. 081088 .. Dear Mr. Peterson: Attached you should find th~ following documents submitted for plan review: 1. An annotated EsGil Plan Check form. · 2. A corrected sheefA-105-3 showing the path of travel from the parking area to the front door of the facility. 3. A corrected Sheet E2.1 coordinating the classified locations in room 133 and 150 noted in the review. Respectfully, Leaford L Blevins Partner I Blevins CUBED Architects NORTH COUNTY OFFICE 1255 PHILLIPS STREET VISTA, CA. 92083 PH: 619 944 41 q7 FAX: B$B 5:38 B486 SAN DIEGO OFFICE 7090 CAMINO PACHECO <SAN DIEGO, CA. 92 1 1 1 PH: 6 1 9 944 4 1 1 5 "\ I, l. _ / i (~ , I' .. I - I I• '. • I - I ' /4 ! BLEVINS CUBED ARCHITECTS ) , Friday, AUgLlft 01, ~008 I "- Mr. David Yao,-Pfam Reviewe 1r Esgil Corporation. · "9320 Chesapeake Drive, Suite 208 San Diego;·,California 92143 " ,, C/0 · r ', _ 1 . \ ' ' Mr. Mike Peter~on·, Plans Examiner City of _C~,rlsbad,, California _ r ' -( RE: 2282 Faraday, -Isis eqblipr:i:ient ~l~trorm ~ ~A -~/UA :~~ ' ,-,,,, a"':',,- plan _Check No.-081088, 2282 Faraday ; · · 1 ,' · ' ,, ___, t ' -Dear Mr. Peterson: '-, l,, ~ -• f , -r \ I. _, Attached you· should fincfthe following qocumbnts submitted fm plan review: , 1., An annotated copy -of th~ EsGil review comme,:its.. ._ 1 2. Revis·ed bubbled.plans·from each,ofth~ disciplines noted in the Plan Review. ~ I ' ' ' ' \ _':" ) . . ~ -. In adqition to addressing· the comments we, also mad~ the following changes in the drawings, lhese change$ -are also bubbled 'on the drawings: ' '-3. On ther second/ floor of the building it was noted that the late~t background files did . ' . I not correctly ·show a small conferenc~ room area. That -ehalige has been made in . "the plan~, and applied to the ~~it plan f~r the space_. No ch,ange in the exit sch!3me from the second floor was required as-a result of this chan9e.. , \/Ve,ho.pe e>ur replies have satisfied your plan review comments: lfarjy outstanding issues r~main, plea_se let m~ kf!OW. ,' -_. . _ " ·-1 • _ • " -· ,· Respectfully,~- -Leaford L. Blevin's .J. Partner/Blevins· CUBED Arcliitects NpR'rH COL/NTY OFFICE 1 25S PHIL;LIPS STREET Vl,STA, CA. 920B3 ; .. PH: 6 1 9 944 41 07 .d ' . /' ""' :, \ I .\ ~ ·, .. SAN DIEGO OFFICE 9921 CARMEi;, ~OUN'i'AIN ROAD #291 "I' SAN DIEGO, CA, 92 1 1 1 '· 4 PH: 6 1 9 944 4 1 1 S !, , FX: 760 47,7 6032 \ \ ( , " F-Xf BSB 53B B486 '( • ' , l I ,, ( ' r' I ~ / (]~()fla~~ City of Carlsbad 081088 6/20/08 Please make all corrections, as requested in the correction list. Submit three new complete sets of p.lans for commercial/industrial projects (two sets of plans for residential projects). For expeditious processing, corrected sets can be submitted in one of two ways: 4. 1. Deliver all corrected sets of plans and calculations/reports directly to the City of Carlsbad Building Department, 1635 Faraday Ave., Carlsbad, CA 92008, (760) 602-2700. The City will route the plans to EsGil Corporation and the Carlsbad Planning, Engineering and Fire Departments. 2. Bring one corrected set of plans and calculations/reports to EsGil Corporation, 9320 Chesapeake Drive, Suite 208, San Diego, CA 92123, (858) 560-1468. Deliver all remaining sets of plans and calculations/reports directly to the City of Carlsbad Building Department for routing to their Planning, Engineering and Fire Departments. NOTE: Plans that are submitted directly to EsGil Corporation only will not be reviewed by the City Planning, Engineering and Fire Departments until review by EsGil Corporation is complete. Keynote 4 on sheet A-401-4.2 shows door 1178 is 60 minutes. The door schedule on A-601 shows door 1178 20 minutes. Please clarify. Sheet A.-401-4.2 shows door 165A is 20 minutes. Door schedule on sheet A-601 did not show door, 165A. Please check. IBC requires the Building Official to determine the total value of all construction work proposed under this permit. The value shall include all finish work, painting, roofing, electrical, plumbing, heating, air conditioning, elevator, fire extinguishing systems and any other permanent equipment. Please provide the designer's or contractor's construction cost estimate of all work proposed. Please refer to the following corrections for electrical and mechanical items. DISABLED ACCESS REVIEW LIST DEPARTMENT OF STATE ARCHITECT TITLE 24 The following disabled access items are taken from the 2007 edition of California Building Code, Title 24. Per Section 109.1, all publicly and privately funded public accommodations and commercial facilities shall be accessible to persons with disabilities. NOTE: All Figures and Tables referenced in this checklist are printed in the California Building Code,:Tltle 24. ,, • REMODELS, ADDITIONS AND REPAIRS City of Carlsbad 081088 6/20/08 1. When alterations, structural repairs or modifications or additions are made to an existing building, that building, or portion of the building affected, is required to comply with all of the requirements for new buildings, per Section 11348.2. These requirements apply as follows: a) The area of specific alteration, repair or addition must comply as "new" construction. A primary entrance to the building and the primary path of travel to the ~ altered area, must be shown to comply with all accessibility features. fr) ./l~v. Existing sanitary facilities that seNe the remodeled area must be shown to \" 90.mply with all accessibility features. "V> .r \k ~ ·· Existing d~inking fountains (if any) must be shown to comply with all "'-·~ accessibility features. 'I?( e) Existing public telephones (if any) must be shown to comply with all accessibility features. 5. To speed up the review process, note on this list (or a copy) where each correction item has been addressed, i.e., plan sheet, note or detail number, calculation page, etc. 6. Please indicate here if any changes have been made to the plans that are not a result of corrections from this list. If there are other changes, please briefly describe them and where they are located in the plans. Have changes been made to the plans 01ot resulting from this correction list? Please indicate: D Yes D No 7. The juris9iction has contracted with Esgil Corporation located at 9320 Chesapeake Drive, Suite 208, San Diego, California 92123; telephone number of 858/560-1468, to perform the plan review for your project. If you have any questions regarding these plan review items, please contact David Yao at Esgil Corporation. Thank you. ,, City of Carlsbad 081088 6/20/08 PLUMBING, MECHANICAL, ELECTRICAL, and ENERGY CORRECTIONS PLAN REVIEWER: Eric Jensen .~ ~ . . " ARCHITECTURAL PME ITEMS ~ ~ Room 122 has "future boilers" (2) shown, (1) installed on the electrical, and no specifics on the mechanical or plumbing? Address the status of the boiler( s) with this permit. 2._ j There is a set of prints attached with the set of plans labeled: Automation and ~ expansion project". Are the mechanical and electrical plans a summary of the y · permittable changes shown in the automation plans or are the automation plans 'Y-J in addition to the mechanical and electrical plans? For example: Sheet E2.3, .. \ ~ column lines 2/A 1 has no new electrical but on the automation plans a new vapor J'!( ,~ recovery system is installed. Sheet E112 (automation) has an area (145) that \i-> · f',.I)} · references another electrical sheet (E103) that has electrical improvements on \/.. /' the standard (nonautomation) set. r/.. ELECTRICAL (2005 NATIONAL ELECTRICAL CODE) B. The electrical redesign for area 146 is missing (sheet E2.2). Please include with 4 the electrical pla_ns and describe any classified locations in this area. Are.a -151 has an expanded fume hood: Describe the location of the "up and down" crane control and its' relative location to any classified locations adjacent to the fume hood. rf./' ;V· Sheet E111 and E112 (automation) have classified locations that are shown on the electrical floorplans. On the standard electrical plans reference any classified detail sheets that concern areas covered by this permit. PLUMBING (2006 UNIFORM PLUMBING CODE) • No plumbing plans submitted. If any plumbing is to be covered by this permit, please include with the next submittal. J6. MECHANICAL (2006 UNIFORM MECHANICAL CODE) Room 165 is designed as an occupancy separation, provide damper protection where required. (SFD@ wall lines). f Hie; \0 7. Corridor 125 is a rated corridor. Provide SFD damper protection so as to maintain the fire separation rating of the corridor. Note: If you :have any,questions regarding this Electrical, Plumbing, Mechanical, and Energy pla·n review list please contact Eric Jensen at (858) 560-1468. To speed the review process, note on this list (or a copy) where the corrected items have been addressed on the plans. END Job Name: Isis PLAN REVIEW SHEET FOR PLAN CHECK ., COMMENTS RESPONSES The electrical redesign for area 14G is Sheet E2.2 not provided. missing-(sheet E2.2). Please include with the electrical plans and describe any classified locations in this area. Area 151 has an expanded fume hood: The location of this existing unit has no 'H' Describe the location of the "up and occupancy classification. See down" crane control and its' relative Architectural plans to determine location to any classified locations classification. adjacent to the fume hood. Sheet E111 and E112 (automation) have Electrical doest not touch any classified classified locations that are shown on areas in this project. Please verify the electrical floorplans. On the standard classification of each room with electrical plans reference any Architectural. classified detail sheets that concern areas covered.by this permit. ,, ,, EsGnl Corporation In !J.'urtnersfiip witli. <ju·oernmerit fur CJ3uilitiug Safety ~ "'\\II;.\ 0 DATE: 8/28/08 JURISDICTION: City of Ca:rlslbad PLAN CHECK NO.: 081088 PROJECT ADDRESS: 2282 Faraday PROJECT NAIVIE: fails Pha:rmaceuticals T. JL SET: H ----------·-·---.. co APP[...IC~ 0 JURIS·. · 0 PLAN REVIEWER 0 FILE [__I The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's building codes. l--] The plans transmitted herewith will substantially comply with the jurisdiction's building codes when minor deficiencies identified below are resolved and checked by building department staff. [] The plans transmitted herewith have significant deficiencies idenlified on the enclosed check list and should be corrected and resubmitted for a complete recheck. [8J The check list transmitted herewith is for your information. The plans are being held at Esgil Corporation until corrected plans are submitted tor recheck. ,, r··-1 The applicant's copy of the check list is enclosed for the jurisdiction to forward to the applicant contact person. · · · r8:] The applicant's copy of the check list has been sent to: Leaf Blevines 1255 Phillips Street Vista, CA 92083 [J Esgil Corporation staff dud not advise the applicant that the plan check has been completed. IZ] Esgil Corporation staff dlkll advise the applicant that the plan check has been completed. ·· Person corrtadea: Je~!!3lyeines Telephone#: 619-9~4-4i07 Date contacted: //2 f;'Oqby:/2!;3) Fax #: 760-477-6032 / ~-Mail V Telephone Faxv In Person [Z] REMARKS: The constrnctuol!1l va!IUle fo1r Une project !has lbeellll rrevised. By: lDavid Yao Enclosures: Esgil Corporation ,, D GA D IVIB ISi EJ D PC 8/2"1 9320Chesapeakc.:l)rive,Suilc.:208 + SauDiego.Calirornia92l23 + (858):'i(l0-l4(i8 + hix.(858)5(i0-l:5l0 Chy of Cadslbad 081088 8/28/08 RECHECK CORRECTION UST JURISDICTION: City of Ca:dslbad PROJECT ADDRESS: 2282 Faraday DA TE PLAN RECEIVED BY ESGIL CORPORATIOl\l: 8/21 REVIEVVED BY: David Yao IFOREW'ORD (PLEASE READ): PLAN CHECK NO.: 081088 SET: H DATE RECHECK COMPLETED: 8/28/08 ,, This plan review is limited to the technical requirements cor'.ftained in ·-the Building Code, Plumbing Code, Mechanical Code, Electrical Code and ?late laws regulating energy conservation, noise attenuation and disabled access. This plan .review is based on regulations enforced by the Building Department. You may have other corrections based on laws and ordinances enforced by the Planning Department, Engineering Department or other departments. The following items listed need clarification, modification or change. All items must be satisfied before the plans will be in conformance with the cited codes and regulations. The approval of the plans does not permit the violation of any state, county or city law. A. To facmtate rnclheckillllg, please ndelllltufy, lfllext to each! item, the sheet of the pialflls IUlpol!ll wlhuclhi each co1rrnctio1n1 ol!ll tlhis sheet ITTJas beel/11 made aillld! rntum this sheet wiUn the rnvised pia11ns. B. The following items have not been resolved from the previous plan reviews. The original correction number has been given for your reference. In case you did not keep a copy of the prior correction list, we have enclosed those pages containing the outstanding corrections. Please contact me if you have any questions regsirding thes~ items. · .. __ C. Please indicatB here if any changes have been made to thE/pians th~t-are not a result of corrections from this list If there are other changes, please briefly describe them and where they are located on the plans. Have changes been made not r·esulting from this list? OYes 01\!o ,, Chy of Cadslbad 081088 8/28/08 No respolll!se was provided to Esgni Corp. Please make all corrections, as requested in the correction list. Submit three new complete sets of plans for commercial/industrial pmjects (two sets of plans.for resider:itial projects). For expeditious processing, corrected sets can be submitted in-one of twcf w·ays: 1. Deliver all corrected sets of plans and calculations/repqrts directly to the City of Carlsbad Building Department, 1635 Faraday Ave., Carlsba'd, CA 92008, (760) 602-2700. The City will route the plans to EsGil Corporation and the Carlsbad Planning, Engineering and Fire Departments. 2. Bring one corrected set of plans and calculations/reports to EsGil Corporation, 9320 Chesapeake Drive, Suite 208, San Diego, CA 92123, (858) 560-1468. Deliver all remaining sets of plans and calculations/reports directly to the City of Carlsbad Building Department for routing to their Planning, Engineering and Fire Departments. NOTE: Plans that are submitted directly to EsGil Corporation only will not be reviewed by the City Planning, Engineering and Fire Departments until review by EsGil Corporation is complete. rnsABlED ACCESS REVIEW UST DEPARTMENT OF STATE ARCHffECT TfflE 24 The following disabled access items are taken from the 2007 edition of California Building Code, Title 24. Per Section 109. 1, all publicly and privately funded': public ac;commodations and commercial facilities shall be accessible to persons with disabilitie~. I\IOTE.: All Figures and Tables referenced in this checklist are pr:inted in the California Building Code, Title 24. "' REMODElS, ADDffiONS AND REPAIRS 1. When alterations, structural repairs or modifications or additions are made to an existing ·· ) building, that building, or portion of the building affected, is required to comply with all of the ~ --~equirements for new buildings, per Section 1-134B.2. These requirements apply as follows: I f 1 The area of specific a!teratio~, _repair or additi~n must ~omply as "new" construction. ~ ~ /-\ primary entrance to the building and tlhe pnmairy path of travel to the altered ,,N ~1 1 arna, mil.list be shown to comply with all accessibility features. '1. f ~-c) Existing sanitary facilities that serve the remodeled area must be shown to comply 1 ~ with all accessibility features. '('" /' d) Existing drinking fountains (if any) must be shown to comply with all accessibility "' features. · ,, · \ e) Existing public telephones (if any) must be shown to comply with all accessibility features. ·· I J, Cii'il:y of Cadslbad 081088 8/28/08 To speed up the review process, note on this list (or a copy).where ea~h correction item has been addressed, i.e., plan sheet, note or detail number,. calculation page, etc. Please indicate here if any changes have been made to the plans that are not a result of corrections from this list. If there are other changes, please briefly describe them and where they are located in the plans. ,, · Have challllges bee1111 made to the plains !fllot iresllllWlfllg from this correction list? Please indicate: 0 Yes D No The jurisdiction has contracted with Esgil Corporation located at 9320 Chesapeake Drive, Suite 208, San Diego, California 92123; telephone number of 858/560-1468, to perform the plan review for your project. If you have any questions regarding these plan review items, please contact David Yao at Esgil Corporation. Thank you. PLUMBING, MECHANICAL, ElECTRiCAl, and ENERGY CORRECTIONS ARCHITECTURAL PME ffEMS ,, ElEClmCAl (2005 NATIONAL ELECTmCA~ CODE) · Sheet Ei 11 and Ei 12 (automation) hcive classified locations'that are shown on the electrical floorplans. On the standard electrical plans reference any classified detail sheets that concern areas covered by this permit. Sheet E11 'f has classified locations described in rooms 'I 33 & 'I 50 that are not addressed on sheet E2. 1. Note: If you have any questions regarding this Electrical, Plumbing, Mechanical, and Energy plan review list please contact Eric Jensen at (868) 560-·l468. To speed the review process, note on this list (or a copy) where the corrected items have been addressed on the plans. END ,, PLANNING/ENGINEERING APPROVALS PERMIT NUMBER CB081088 DATE 6/9/08 ADDRESS 2282 FARADAY AV TENANT IMPROVEMENT OTHER -- PLANNER DEBO~ ENGINEER'-0, ___ __,,~'----=--....;._--=-----DATE 11:\ADMIN\COUNTER/PLANNING/ENGINEERING APPHOVAIS DATE 6/13/08 Carlsbad Fire Department Plan Review Requirements Category: TI , COMM Date of Report: 09-24-2008 Name: Address: Permit #: CB081088 BLEVINS LEAF 1255 PHILLIPS ST VISTA CA 92083 Job Name: ISIS --1500 SF INTERIOR Job Address: 2282 FARADAY AV CBAD BlHLDING DEPTo COPY Reviewed by: --4~. ~~ .... ···-~·--= r review is incomplete. At this time, this office cannot adequately conduct a review todeterinine compliance with the applicable codes and/or standards. Please review carefully all comments attached. Please resubmit the necessary plans and/or specifications, with changes "clouded", to this office for review and approval. Conditions: Cond: CON0003075 [MET] (: APPROVED) ' THIS PROJECT HAS BEEN REVIEWED AND APPROVED FOR THE PURPOSES OF ISSUANCE OF BUILDING PERMIT. THIS APPROVAL IS SUBJECT TO FIELD INSPECTION AND REQUIRED TEST, NOTATIONS HEREON, CONDITIONS IN CORRESPONDENCE AND CONFORMANCE WITH ALL APPLICABLE REGULATIONS. THIS APPROVAL SHALL NOT BE HELD TO PERMIT OR APPROVE THE VIOLATION OF ANY LAW. Entry: 09/24/2008 By: GR Action: AP KLAUSBRUCKNER AND ASSOCIATES May 28, 2008 Greg Ryan, Assistant Fire Marshal Carlsbad Fire Department 1635 Faraday Ave. Carlsbad, CA 92008 2---- RE: ISIS Pharmaceuticals -228$ Faraday Ave. Inventory Update of Existing H-3 Room Dear Mr. Ryan: 4105 Sorrento Valley Blvd. San Diego, CA 92121 --~~-n fflr:1-~-'ltA __ _ Tel: (858) 677-9878 Fax: (858) 677-9894 Attached is the updated hazardous materials inventory for the existing H-3 Room within the above-mentioned facility. Based on the new inventory the room occupancy will remain as an H-3. If you have any questions or need additional information, do not hesitate to call at 858-677-9878. Sincerely, Elley Klausbruckner Hazardous Materials Consultant I I I I I I I I. I I I I I I I I I I I KLAUSBRUCl<NER AND ASSOCIATES 4105 Sorrento Valley Blvd. San Diego, CA 92121 Tel: (858) 677-9878 Fax: (858) 677-9894 ISIS PHARMACEUTICALS INC. EAST (NEW) H3 GMP SUITE 2282 FARADAY AVE. CARLS:SAD, CA Hazardous Materials Inventory Report Rev. 1.0 May 27, 2008 ciot10 I I I I I I I I I I I I I I I I I I I Rev. 1.0 Report Printed. May 27, 2008 MM n=============,i:=r--=================== DISCLAIMER This report is the property ofKlausbruckner & Associates and was prepared exclusively for use by Isis Pharmaceuticals Inc., for the hazardous materials inventory and occupancy conditions specifically described in this report. The Isis Pharmaceuticals Inc. quantities and locations addressed herein are based on information provided for the report by Isis Pharmaceuticals Inc. Discrepancies between the information presented herein and actual conditions and conditions presented on plans are the sole responsibility oflsis Pharmaceuticals Inc. Verification of compliance with the Code requirements and provisions addressed herein is outside the scope of this report. Copies ofthis report retained by Isis Pharmaceuticals Inc. shall be utilized only by Isis Pharmaceuticals Inc. for the hazardous materials inventory and the 2007 California Codes maximum allowable quantity requirements addressed in this report for the above-mentioned facility. This is a hazardous materials inventory report is for indoor storage and use conditions only. This is not a complete code compliance report. Hazardous materials analysis of the remainder of the building, including adjacent tenant spaces, is not part of the scope of this report. This report shall not be used as, or in lieu of, construction documents or plans for this project or any other project or for any other purpose or conditions not specifically addressed in this report. Rev 1.0 .._\\. l(LAUSOROCKNt::R \\} ANO ASSOCIJ\TE.S Page ii I I I I I I I I I I I I I I I I I I I Table of Contents Report Format Health Hazards: Inventory Totals for Hazard Categories Physical Hazards: Inventory Totals for Hazard Categories Inventory Inventory Sorted by Classification Classification Symbols Classification Definitions Rev 1.0 ~\'" KLAUSBRUCKN~R )}l ANO ASSOCIATES Pa2e 1 2 3 6 20 22 Page iii --------- HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS CBCTABLE307.7(2) -CFC TABLE2703.1.1(2) SUMMARY-HEALTH HAZARD MATERIALS Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite STORAGE Solids Liquid Gas Material Lbs Gins Cf Corrosives 4.2200 Irritants Other Health Hazards Toxics 4.2200 ------ USE CLOSED Solid Liquid Gas Solid Lbs Gins Cf Lbs 317.0000 13.2000 205.9200 454.2500 2007 California Codes: CONTROL AREA IS CLASSIFIED AS A H3 OCCUPANCY BASED ON THE USE and STORAGE OF HEAL TH HAZARD MATERIALS. Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. - USE OPEN Liquid Gins SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-KLAUSBRUCKNER & ASSOC. -5/27/2008-PAGE 1 --- Gas Cf ---------- HAZARDOUS MATERIALS and OCCUPANCY CLASSIFICATION ANALYSIS CBC TABLE 307.7(1)-CFC TABLES 2703.1.1(1) SUMMARY -PHYSICAL HAZARD MATERIALS Isis Phannaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite Material Flammable Liquids 1-8 Water Reactives 1 Solids Lbs 4.2200 STORAGE Liquid Gins 220.0000 Gas Cf Solid Lbs -- USE CLOSED Liquid Gins 490.0900 - Gas Cf -- Solid Lbs 2007 California Codes: CONTROL AREA IS CLASSIFIED AS A H3 OCCUPANCY BASED ON THE USE and STORAGE OF PHYSICAL HAZARD MATERIALS. Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. - USE OPEN Liquid Gins SUMMARY -HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-KLAUSBRUCKNER & ASSOC. -5/27/2008-PAGE 2 - Gas Cf -- ------------------ Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: Hazardous Materials Inventory -ii;~; §Aitt. :.;:_~: . ,._ .. v;:." ,~ ••I,_, 'r''• . :._:-~-.' -~~rd'!c1~~~<:::_· sto~ge· Units_ Us~c1.;~e.d···0~i~:. "t!se-:pp:~,i, ~ Qni~: \~i~!i9-~-:::t·:':' ·'''.. ,, ·:· . ,;-· .... '-,· Stat1i C91_1c% , Material.: · ·,_. · 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL1B, JR, OHH, 0.0000 Gins 26.4000 Gins 0.0000 Gins Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8) [FP 42oF; BP 81oC) [LEL: 3; UEL: 16) [SG 0.786; VD 1.41] [LDS0-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;) [HR: H2 F3) 2 2001-000-397 L 100 Amidite Solution (95% Acetonitrile/75-05-8, 5% FL1 B, JR, OHH, 0.0000 Gins 39.6000 Gins 0.0000 Gins Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8) [FP 42oF; BP 81 oC) [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LDS0-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3) 3 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL1B, JR, OHH, 0.0000 Gins 52,8000 Gins 0.0000 Gins Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC) [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LDS0-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;) [HR: H2 F3] 4 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL1B, IR, OHH, 0.0000 Gins 13.2000 Gins 0.0000 Gins Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC) [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;) [HR: H2 F3) 5 2001-000-397 L 100 Amidite Solution [95% Acetonitlile/75-05-8, 5% FL1B, IR, OHH, 0.0000 Gins 13.2000 Gins 0.0000 Gins Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8) [FP 42oF; BP 81oC) [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LDS0-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3) 6 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL1B, JR, OHH, 0.0000 Gins 13.2000 Gins 0.0000 Gins Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81 oC) [LEL: 3; UEL: 16) [SG 0.786; VD 1.41] [LDS0-0 2730 mg/kg; LC50 21,354 ppm) [LDS0-0 >1,000 mg/kg;] [HR: H2 F3) LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vapor. FLV-Flammable Liquid Vapor. Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. H3-150 SSS Lab [100 Litervessel-26.25 L ACN, 1 kg Amidite H3-150 SSS Lab (150 Litervessel-35.00 L ACN, 1 kg Amidite H3-150 SSS Lab (200 Liter vessel-52.50 L ACN, 1 kg Amidite H3-150 SSS Lab (50 Litervessel-17.5 L ACN, 1 kg Amidite H3-150 SSS Lab [50 Liter vessel-8.75 L ACN, 1 kg Amidite H3-150 SSS Lab [50 Liter vessel -8,75 L ACN, 1 kg Amidite HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 3 - ------------------- Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: Hazardous Materials Inventory . Item ,-CAS#·.: , -:·-~tatE!, Co!1c% 'Materi,al l:iazarc!, Glass· 7 2001-000-397 L 8 2001-000-397 L 9 1310-73-2 s 10 08-1S!S-001 L 11 2002-000-015 L 12 127-09-3 s 13 67-56-1 L 14 08-ISIS-002 L 15 08-ISIS-002 L 16 08-ISIS-002 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL1B, IR, OHH, Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LDS0-0 >1,000 mg/kg;] [HR: H2 F3] 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL1B, IR, OHH, Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81 oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3] 100 Sodium Hydroxide (Caustic Soda] [NAOH] CR, TX, WR1 [Base/Alkaline] [Lewis Red Devil Lye Drain Opener] [APC Caustic Alkaline Cleaner] (APC 500 Heavy Duty Caustic Cleaner] (Cycle AL- 100] [LDLo-0 >/=500 mg/kg] [RTECS# WB4900000] [HR: H3 R1 COR WR] 100 Stripping Mixture [50 %Ammonium Hydroxide CR 1336-21-6; 50% Water] 100 Precipitation Mixture (AceticAcid/64-19-7, CR, FL1B, OHH Sodium Hydroxide/1310-73-2, Ethanol/64-17-5 Water] [Based on Ethanol -FP 55.6oF; BP 78.32oC] [LEL: 3.3%; UEL: 19%] [SG 0.789; VD 1.594] [HR: H3 F3 COR) 100 Sodium Acetate [Acetic Acid Sodium Salt] [MP IR 324oC] [RTECS#AJ4300010] [Aldrich 229873] [HR:H2] >/=50 Methyl Alcohol [Methanol] [Wood Sealer] (Pen FL 1 B, IR Fix] [Reagent Alcohol] [Blue Blox] [MEOH] [FP 52oF; BP 64.7oC/148oF] [LEL: 6%; UEL: 36.5%] [SG 0.791; VD 1.109] [HR: H2 F3] 100 HPLC Fraction [80%Methanol,20%Water] FL1B 100 HPLC Fraction (80% Methanol, 20% Water] FL 1 B 100 HPLC Fraction [80% Methanol, 20% Water] FL 1 B -~tQrage Uili~-Use,.Gio's~~:'.unili?,. u~;-i~eit ·:1:Jnjts:._·L~~~tl6~ > ' ' • ' • ' ' I •.' I ,• ,~ • • • ., 0.0000 Gins 13.2000 Gins 0.0000 Gins 18.4800 Gins 4.2200 Lbs 0.0000 Lbs 0.0000 Gins 52.8300 Gins 0.0000 Gins 264.1700 Gins 0.0000 Lbs 13.2000 Lbs 0.0000 Gins 15.8400 Gins 0.0000 Gins 20.0000 Gins 20.0000 Gins 0.0000 Gins 20.0000 Gins 0.0000 Gins 0.0000 Gins H3-150 SSS Lab [50 Liter vessel -8.75 L ACN, 1 kg Amidite 0.0000 Gins H3-150 SSS Lab (70 Litervessel-17.5 L ACN, 1 kg Amidite 0.0000 Lbs H3-151 Clev/Strip lab 0.0000 Gins H3-151 Clev/Strip lab 0.0000 Gins H3-152 Precipitaion Lab Exhausted Enclosure w/spill control and containment (1000 L vessel-37 L acetic acid, 5 L sodium Hydrox, 793 L EtOH, 20 L Water 0.0000 Lbs H3-152A HPLC Lab, 50 L vessel 0.0000 Gins H3-152A HPLC Lab, 60 L vessel 0.0000 Gins H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water 0.0000 Gins H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water 0.0000 Gins H3-152A HPLC Lab,75 L vessel-52L Methanol, 13 L Water LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vapor. FLV-Flammable Liquid Vapor. Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 4 - ------------------ Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: Hazardous Materials Inventory ; ttell'!, , c,:..s11-. ·. . . Sti!t~f .CO!JC~'_,'M~{e:~ic!i. H~rd,~l~s~ ,, ,>s/ot~g~.: lj~i~,··.4~~~!<;,$ed:·t;Jn.its .Use,;Qpen ·· l;l~its Lo,cc!tiori·.: . ' ' . ' . ~ --. . '' ' ' 17 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 Gins 18 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 Gins 19 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 Gins 20 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 Gins 21 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 Gins 22 08-ISIS-002 L· 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 Gins 23 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 Gins 24 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 Gins 25 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 Gins LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vapor. FLV-Flammable Liquid Vapor. Storage Amount= Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water H3-152A HPLC Lab, 75 L vessel -52 L Methanol, 13 L Water H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 5 - ---------------- Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: Corrosives/LIQUIDS . uerri;,. c~stt/ .'. 08-ISIS-001 . >$fa_t~,-Cone% Material,·· · . . '• ~.:: ~ : L 100 Stripping Mixture [50 %Ammonium Hydroxide 1336-21-6; 50% Water] · Hai,~~!!-9!-i~s/·. .. storag'e :!J~it§; · Us~Cl~sed,:lJ~its. u~i~pen ; ..• v~_ii~ -L~~tip.~t :\:::,, ,_ ' '' ~~~------------~--"'·-'-~ ... , __ .. , ..... CR 0.0000 Gins 52.8300 Gins 0.0000 Gins H3-151 Clev/Strip lab -- • ,,''l_ 2 2002..()00-015 L 100 Precipitation Mixture [AceticAcid/64-19-7, CR, FL1B, OHH Sodium Hydroxide/1310-73-2, Ethanol/64-17-5 0.0000 Gins 264.1700 Gins 0.0000 Gins H3-152 Precipitaion Lab Exhausted Enclosure w/spill control and containment [1000 L vessel- Water] [Based on Ethanol-FP 55.6oF; BP 37 L acetic acid, 5 L sodium Hydrox, 793 L 78.32oC] [LEL: 3.3%; UEL: 19%] [SG 0.789; VD EtOH, 20 L Water 1.594] [HR: H3 F3 COR] :~~JiL~::~tgo1os O;OQOQ Gins 3.11.:Qooo· · Gins · 0}1000;:-.Gi~s-: ,.: ~:11.0000. Gl,n~ .· · LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vvapor. FLV-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. ··.:- HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 6 <,:', •.· - ---------------- Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: Corrosives/SOLIDS _ !tern C-f'.S# --State _ <;:one%-\',1_;:itE!~iaJ · HaZ?r~·,_CJass .. ·.· '!·_._._·,, ,,,. ~ ' ~ ,-,., t ,,.., --,,_ y O .• '• --~-,-.... M • ' ,, , • St9rage · Units_ -use:.<;:tos~cr (!nits-' U~irdpen .. : ·units to.c"'tl.~m: 3 1310-73-2 s ' ' . . . T0:PAL--,Corro~ives/sOqQs 100 Sodium Hydroxide [Caustic Soda] [NAOH] [Base/Alkaline] [Lewis Red Devil Lye Drain Opener] [APC Caustic Alkaline Cleaner] [APC 500 Heavy Duty Caustic Cleaner] [Cycle AL- 100] [LDLo-O >/=500 mg/kg] [RTECS# WB4900000] [HR: H3 R1 COR WR] ,• ,. ' ,, ·: ;· .. 'L :<· ·t· '"::: .~-I,: :'1 ,· , ~· ,: AG~f{!;GA.T,~ TC?l'AL ~ Co~q.siv~s!S9AIP~'.· •·:·: -.:. '· ... CR,TX,WR1 ,,. ·,. .{[ . : ,--~----'~-~ 4.2200 Lbs 4.2200' Lbs: .'.' ,.4,2200· 'lbs ·~ ' : ' . -. 0.0000 Lbs 0.0000 Lbs H3-151 Clev/Strip lab ·1:~,~-~ilb}~~//(} PiOQO : Lbs ,J.•,-;:_'·' LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vvapor. FLV-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 7 -- . ~ •:. ' ,; \~ .. :_ ,~:· ,. - ------------------ Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: Flammable Liquids 1-B/LIQUIDS 'Item:. CAS#::~; -: '·:: skte~"c:c!,·rig%: _'.:Materiai : ", . Hazard Class · . ·· Stp~g~:_: l,l~l~/U$'~G!~~e# .:units ·u~e-OJ)en .. 9~~ t:o~ation::. · . : .. ..-• • '_ ,, ' • • , ' , \ ~ ' • , .' C 7, • t. .~,. ,' : . , • '• . -, .. ., ··-:.' .. "'•. ,.. ,,,_._, --. ,. 4 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL1B, IR, OHH, 0.0000 Gins 18.4800 Gins 0.0000 Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3] 5 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL1B, IR, OHH, 0.0000 Gins 13.2000 Gins 0.0000 Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3] 6 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL 1 B, IR, OHH, 0.0000 Gins 26.4000 Gins 0.0000 Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] {SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3] 7 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL1B, IR, OHH, 0.0000 Gins 39.6000 Gins 0.0000 Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LDS0-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3] 8 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL 18, IR, OHH, 0.0000 Gins 13.2000 Gins 0.0000 Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3] 9 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL1B, IR, OHH, 0.0000 Gins 13.2000 Gins 0.0000 Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [l.D50-0 >1,000 mg/kg;] [HR: H2 F3] LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vvapor. FLV-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. Gins H3-150 SSS Lab (70 Litervessel-17.5 LACN, 1 kgAmidite Gins H3-150 SSS Lab [50 Litervessel-17.5 LACN, 1 kg Amidite Gins H3-150 SSS Lab [100 Liter vessel -26.25 L ACN, 1 kg Amidite Gins H3-150 SSS Lab [150 Litervessel-35.00 L ACN, 1 kg Amidite Gins H3-150 SSS Lab [50 Liter vessel-8.75 L ACN, 1 kg Amidite Gins H3-150 SSS Lab [50 Litervessel-8.75 LACN, 1 kg Amidite HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 8 - ------------------ Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: Flammable Liquids 1-8/LIQUIDS Item· CAS# •',•' '~State·--~011c% ~aterfaI.< '.: :· ·. -. ,', .. ;';/:><·,.;:···' )iaj~rd.'.Gl~~s ~t~rage, .. Li,11its ~u;~~lose~: IJ~it;:;~.d~d~-~~ i-i[n.;~: ,l;~;tion ' : . ~. ,., :, . ~· ' . : , • ' • '< ·• ~ •· •• -' -~-~.' -,, .. 10 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL 1 B, IR, OHH, 0.0000 Gins 52.8000 Gins 0.0000 Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-O 2730 mg/kg; LC50 21,354 ppm] [LD50-O >1,000 mg/kg;] [HR: H2 F3] 11 2001-000-397 L 100 Amidite Solution (95%Acetonitrile/75-05-8, 5% FL1B, IR, OHH, 0.0000 Gins 13.2000 Gins 0.0000 Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81 oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-O 2730 mg/kg; LC50 21,354 ppm] [LD50-O >1,000 mg/kg;] [HR: H2 F3] 12 2002-000-015 L 100 Precipitation Mixture [Acetic Acid/64-19-7, CR, FL 1 B, OHH 0.0000 Gins 264.1700 Gins 0.0000 Sodium Hydroxide/1310-73-2, Ethanol/64-17-5 Water] [Based on Ethanol-FP 55.6oF; BP 78.32oC] [LEL: 3.3%; UEL: 19%] [SG 0.789; VD 1.594] [HR: H3 F3 COR] 13 67-56-1 L >/=50 Methyl Alcohol [Methanol] [Wood Sealer] [Pen FL1B, IR 0.0000 Gins 15.8400 Gins 0.0000 Fix] [Reagent Alcohol] [Blue Blox] [MEOH] [FP 52oF; BP 64.7oC/148oF] [LEL: 6%; UEL: 36.5%] [SG 0.791; VD 1.109] [HR: H2 F3] 14 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 15 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 16 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 17 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 18 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 19 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 20 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 20.0000 Gins 0.0000 Gins 0.0000 LEV: Local or generaVarea exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vvapor. FLV-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Automalic fire splinkler system protection. -· •' Gins H3-150 SSS Lab (200 Liter vessel -52.50 L ACN, 1 kg Amidite Gins H3-150 SSS Lab (50 Litervessel-8.75 LACN, 1 kg Amidite Gins H3-152 Precipitaion Lab Exhausted Enclosure w/spill control and containment [1000 L vessel- 37 L acetic acid, 5 L sodium Hydrox, 793 L E!OH, 20 L Water Gins H3-152A HPl:.C Lab, 60 L vessel Gins H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water Gins H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water - Gins H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water Gins H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water Gins H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water Gins H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water Gins H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 9 - --------!---------- Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: Flammable Liquids 1-8/LIQUIDS "Item <:;AS#'' . t--~ -'. •. '· ~!8te • Cone,% Materia); ;.=; · · .. -· . .. Hazard· ciass ,, ,_,,.,_. '. 21 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 22 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL18 23 08-ISIS-002 L 100 HPLC Fraction (80% Methanol, 20% Water] FL18 24 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 25 08-ISIS-002 L 100 HPLC Fraction [80% Methanol, 20% Water] FL1B 'st~ragr:~:n.l~ .. 9~f ~1f~':4-~nits,: 'l.~s~~pe~· .. · u~i~ .. ,:L.9caJion . , ' ',, ' ~--------· ' ·--. -. -· - 20.0000 Gins· 0.0000 Gins 0.0000 Gins H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water 20.0000 Gins 0.0000 Gins 0.0000 Gins H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water 0.0000 Gins 20.0000 Gins 0.0000 Gins H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water 20.0000 Gins 0.0000 Gins 0.0000 Gins H3-152A HPLC Lab, 75 L vessel-52 L Methanol, 13 L Water 20.0000 Gins 0.0000 Gins 0.0000 Gins H3-152A HPLC Lab, 75 L vessel -52 L Methanol, 13 L Water ,.i :::::t;f !~:::t~i~:ij~ 22Q~!J~~o;. Gl~~s~i/.{~~()~M:!)O: ~!ii~ · o.oopo,. Glris· .. -,= -'~ "r , • ·:-• '• • ; ~. t • (':-:~::-.; ',f,A. , :·:.." ', .110.0900• Gins:.,.,.. ·<._ , .... • • ···A;,~~--~ > ,,::_;.-:,i~{~~~ LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vvapor. FLV-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -KLAUSBRUCKNER & ASSOC. -5/27/2008-PAGE 10 '!,; ·:i', :· -:~· ~ . j, '<~.:-}.{~: - ------· ------------ Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: Irritants/LIQUIDS lt~qi. C'AS#f'. .• .' , .s~te -c~nc%, ·-M~i~r_i.i(ij:\ );:~, • '.,,/:_' ·.' ;-. : . · · : , : iiiizj'rd ~.a:;~:·'.",·. :st?!~g~.' :\fni~ · U~e-Gl~~~J ",u~its ·u~;;9pen' Units, l,.qcatjon' ·. . .,. -' ' , 26 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL1B, IR, OHH, 0.0000 Gins 18.4800 Gins 0.0000 Gins H3-150 SSS Lab [70 Litervessel-17.5 L ACN, Deoxynucleoside Phosphoramidite & P65 1 kg Amidite Tetrazole/288-94-8] [FP 42oF; BP 81 oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3] 27 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL 18, IR, OHH, 0.0000 Gins 13.2000 Gins 0.0000 Gins H3-150 SSS Lab [50 Litervessel-17.5 L ACN, Deoxynucleoside Phosphoramidite & P65 1 kg Amidite Tetrazole/288-94-8] [FP 42oF; BP 81oC] [I.EL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3] 28 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL18, IR, OHH, 0.0000 Gins 13.2000 Gins 0.0000 Gins H3-150 SSS Lab [50 Litervessel-8.75 L ACN, Deoxynucleoside Phosphoramidite & P65 1 kg Amidite Tetrazole/288-94-8] [FP 42oF; BP 81 oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3] 29 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL18, IR, OHH, 0.0000 Gins 26.4000 Gins 0.0000 Gins H3-150 SSS Lab (100 Liter vessel -26.25 L Deoxynucleoside Phosphoramidite & P65 ACN, 1 kg Amidite Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3] 30 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL 18, IR, OHH, 0.0000 Gins 13.2000 Gins 0.0000 Gins H3-150 SSS Lab (50 Litervessel-8.75 L ACN, Deoxynucleoside Phosphoramidite & P65 1 kg Amidite Tetrazole/288-94-8] [FP 42oF; BP 81 oC] [I.EL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3] 31 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL18, IR, OHH, 0.0000 Gins 39.6000 Gins 0.0000 Gins H3-150 SSS Lab [150 Liter vessel-35.00 L Deoxynucleoside Phosphoramidite & P65 ACN, 1 kg Amidite Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3] 32 67-56-1 L >/=50 Methyl Alcohol [Methanol] [Wood Sealer](Pen FL18, IR 0.0000 Gins 15.8400 Gins 0.0000 Gins H3-152A HPLC Lab, 60 L vessel Fix] [Reagent Alcohol] [Blue Blox] [MEOH] [FP 52oF; BP 64.7oC/148oF] [LEL: 6%; UEL: 36.5%] (SG 0.791; VD 1.109] [HR: H2 F3] LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vvapor. FLV-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 11 - -,_ ·----· -------· ----- Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: Irritants/LIQUIDS ltell'!, ,.CAS#· ~tat!!·)~o~~'.¼ :'tJia.tiirial ,Ha~~~ ·c,~.~~ St~6ge,· .yni~. U~e~Closed:,'. Un(ts i.J~~OP!l"· t,Jnits, Loc~tip--;;.,:;)} _; ... ,, .... : ";,/,:..; 33 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL 1 B, IR, OHH, Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LDS0-O 2730 mg/kg; LC50 21,354 ppm] [LDS0-O >1,000 mg/kg;] [HR: H2 F3] · 34 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL1B, IR, OHH, Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LDSO-b 2730 mg/kg; LC50 21,354 ppm] [LD50-O >1,000 mg/kg;] [HR: H2 F3] . ,:TOTAL)~_,rri~~,~?t~~~'~f~,;,\ff r: ;: . \.-.. A~GREGJ\'T!= 'tC?_,TA\:,'.;-:,,lrr,i.!~'.1,~/~,:~µu~~ ' 1_'. ,-, :·' ~--~ 0.0000 Gins 52.8000 Gins 0.0000 Gins 13.2000 Gins .:: :~fio~i('c;l-~f i·;:: ·~~i,_~2Ao:· G1n·s · I • • ;, :, -~:,: :.,.,i~, • :~ · ;,205;9200!iGlns, , •::. ..,, ' ... :.,.:!_·, 0.0000 Gins H3-150 SSS Lab [200 Litervessel-52.50 L ACN, 1 kg Amidite 0.0000 Gins H3-150 SSS Lab [50 Litervessel-8.75 LACN, 1 kg Amidite O.QOOO: 'Gin~···.· . · ::,.-_'! ._,. ~.- ,·.,, .. ·' LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vvapor. FLV-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 12 - ---------.. -·------ Isis Pharmaceuticals Inc. 0 2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: Irritants/SOLIDS · 'item? ·cAs#.· ,· · ' ---~h • _, ,,. State ' .Cc;mc% ·Material ·i-ia~~d,:Class· · .-· -' ._ '.~ . -':_ Storage Units !:J~e-Closed Units, l,l~~Qpen'· ._._U!)it~. · l;.oc;~tJ,oi/':··. ' . . 35 127-09-3 S 100 Sodium Acetate [Acetic Acid Sodium Salt) [MP 324oC) [RTECS#AJ4300010) [Aldrich 229873] IR 0.0000 Lbs 13.2000 Lbs 0.0000 Lbs H3-152A HPLC Lab, 50 L vessel [HR:H2] yO 7~ r •,-; ',"•}",' < •" ·c,;;;-;.-··,;-•• • '.17Q:J'AL"-·lrritants/SOLIDS ,· . ·_;;;;~:-!-~-; "'"/:: i_·.. --. '.~G~R~G~TE;TOTAL -lrrita~ts/S0L:IDS . • A,,".· "f, •,,~;..•" • • ' -,_;, '' "" -,--• • • • :··: ,, ... . :,o:Q000 ,Lb.s· 13.2090 Lbs.,,,,: . · Q:9,9'QQ·~·i_b~~,> .. . ' ,' ~ . . . r. ' ·.·. -:--.. J~;fopo !-:bs . ·:. :, '. -~ ,:.,, i·:·:. - .. _,, -. ~: -l-::i >-· LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vvapor. FLV-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 13 -- ,>-·,.· \ rl ------------------ Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: Other Health Hazards/LIQUIDS · Item GAS# •·. ' ',,, ,, • ".T •, ~ · ·.· . .',t-i;dard. ci~ss St~rag~ U~its lJs~q1q~~d: ,Uni~,; t!~~qp~n -Units location-_' .State Cone'¾· Mat.erial.C·.· ... · .. , ... : :., '' ,, '' ~" -•' , .-T ,-. ; 36 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL 1 B, IR, OHH, 0.0000 Gins 13.2000 Gins 0.0000 Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41][LD50-0 2730 mg/kg; LCSO 21,354 ppm] [LDS0-0 >1,000 mg/kg;] [HR: H2 F3] 37 2001-000-397 L 100 Amidite Solution (95%Acetonitrile/75-05-8, 5% FL1B, IR, OHH, 0.0000 Gins 13.2000 Gins 0.0000 Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LDS0-0 2730 mg/kg; LC50 21,354 ppm] [LDS0-0 >1,000 mg/kg;] [HR: H2 F3] 38 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL1B, IR, OHH, 0.0000 Gins 13.2000 Gins 0.0000 Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LCSO 21,354 ppm] [LDS0-0 >1,000 mg/kg;] [HR: H2 F3] 39 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL1B,IR,OHH, · 0.0000 Gins 13.2000 Gins 0.0000 Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81 oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LCSO 21,354 ppm] [LDS0-0 >1,000 mg/kg;] [HR: H2 F3] 40 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL1B, IR, OHH, 0.0000 Gins 18.4800 Gins 0.0000 Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LDS0-0 2730 mg/kg; LC50 21,354 ppm] [LDS0-0 >1,000 mg/kg;] [HR: H2 F3] 41 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL 1 B, IR, OHH, 0.0000 Gins 26.4000 Gins 0.0000 Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LDS0-0 2730 mg/kg; LCSO 21,354 ppm] [LDS0-0 >1,000 mg/kg;] [HR: H2 F3] LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vvapor. FLV-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. Gins H3-150 SSS Lab [50 Litervessel-17.5 L ACN, 1 kg Amidite Gins H3-150 SSS Lab [50 Litervessel-8.75 LACN, 1 kg Amidite Gins H3-150 SSS Lab [50 Litervessel-8.75 LACN, 1 kgAmidite Gins H3-150 SSS Lab [50 Liter vessel-8.75 L ACN, 1 kg Amidite Gins H3-150 SSS Lab [70 Litervessel-17.5 L ACN, 1 kgAmidite Gins H3-150 SSS Lab [100 Liter vessel -26.25 L ACN, 1 kg Amidite HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-KLAUSBRUCKNER & ASSOC. -5/27/2008-PAGE 14 - ------------------ Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New} H3 GMP Suite: Other Health Hazards/LIQUIDS . lte!!l CAS#'. -l?~t~ _'·Go~~% M~t~r.ial -..... ' ' : Haz~rd ci~~~' 'st¢rt;tg~ \µ~1~·:· Use-Clgsed .. Units ·t:i~:~Op_en · l;Jnits: Lo~ation ·_' _; · ,::, ' '·, • ',. •. t• • • • -• -._ .i 42 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL1B, IR, OHH, 0.0000 Gins 39.6000 Gins 0.0000 Gins H3-150 SSS Lab (150 Litervessel-35.00 L Deoxynucleoside Phosphoramidite & P65 ACN, 1 kg Amidite Tetrazole/288-94-BJ [FP 42oF; BP 81oCJ [LEL: 3; UEL: 16) [SG 0.786; VD 1.41) [LD50-0 2730 mg/kg; LC50 21,354 ppmj [LD50-0 >1,000 mg/kg;] [HR: H2 F3J 43 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL 1 B, IR, OHH, 0.0000 Gins 52.8000 Gins 0.0000 Gins H3-150 SSS Lab (200 Liter vessel-52.50 L Deoxynucleoside Phosphoramidite & P65 ACN, 1 kg Amidite Tetrazole/288-94-8) [FP 42oF; BP 81oC) [LEL: 3; UEL: 16J [SG 0.786; VD 1.41) [LD50-0 2730 mg/kg; LC50 21,354 ppmj (LD50-0 >1,000 mg/kg;] [HR: H2 F3) 44 2002-000-015 L 100 Precipitation Mixture [AceticAcid/64-19-7, CR, FL1B, OHH 0.0000 Gins 264.1700 Gins 0.0000 Gins H3-152 Precipitaion Lab Exhausted Enclosure Sodium Hydroxide/1310-73-2, Ethanol/64-17-5 w/spill control and containment [1000 L vessel- Water] [Based on Ethanol -FP 55.6oF; BP 37 L acetic acid, 5 L sodium Hydrox, 793 L 78.32oC) [LEL: 3.3%; UEL: 19%] [SG 0.789; VD EtOH, 20 L Water 1.594) [HR: H3 F3 COR] I9~~~ _-·Otb~f:H~~_itf 1~~~\l~pi~{/ _,-r( _ . : __ ._ ,AGGR_EGAlil;' :rpTAI,. ~. 9.t!t~.rl-!~;al,!1:Haziuds/tlqUIDS " , <~~t::t ~'.12500 Goos 0.0000. Qlos LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vvapor. FL V-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 15 .·,. - ------------------ Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: CA-Prop65/LIQUIDS . Item· ·.CAS#._. · : State·.' done% ,Material ,,_ ·, :. .,. . . . ..i~iird. C!.~ss · 45 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL1B, IR, OHH, Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG'0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;] [HR: H2 F3] 46 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL1B, IR, OHH, Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-0 2730 mg/kg; LC50 21,354 ppm) [LD50-0 >1,000 mg/kg;] [HR: H2 F3] 47 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL1B, IR, OHH, Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8) [FP 42oF; BP 81oC) [LEL: 3; UEL: 16] [SG 0.786; VD 1.41) [LDS0-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;) [HR: H2 F3) 48 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL 1 B, IR, OHH, Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8) [FP 42oF; BP 81oC) [LEL: 3; UEL: 16] [SG 0.786;VD 1.41) [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;) [HR: H2 F3) 49 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL 1 B, IR, OHH, Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8) [FP 42oF; BP 81oC) [LEL: 3; UEL: 16) [SG 0.786; VD 1.41) [LD50-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;) [HR: H2 F3] 50 2001-000-397 L 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% FL1B, IR, OHH, Deoxynucleoside Phosphoramidite & P65 Tetrazole/288-94-8) [FP 42oF; BP 81oC) [LEL: 3; UEL: 16) [SG 0.786; VD 1.41) [LDS0-0 2730 mg/kg; LC50 21,354 ppm] [LD50-0 >1,000 mg/kg;) [HR: H2 F3] . '.·st~ragii. Units Use,.Closed Units -Use-Open . -' ... ~ -. . . . ' . . ',•... ,·· Uni~· :Locati<>/1 .... :.:..-, , . ·t 0.0000 Gins 13.2000 Gins 0.0000 Gins 18.4800 Gins 0.0000 Gins 13.2000 Gins 0.0000 Gins 26.4000 Gins 0.0000 Gins 13.2000 Gins 0.0000 Gins 52.8000 Gins 0.0000 Gins H3-150 SSS Lab [50 Litervessel-17.5 LACN, 1 kg Amidite 0.0000 Gins H3-150 SSS Lab [70 Litervessel-17.5 LACN, 1 kg Amidite 0.0000 Gins H3-150 SSS Lab [50 Litervessel-8.75 L ACN, 1 kgAmidite 0.0000 Gins H3-150 SSS Lab [100 Liter vessel -26.25 L ACN, 1 kg Amidite 0.0000 Gins H3-150 SSS Lab [50 Liter vessel -8.75 L ACN, 1 kg Amidite 0.0000 Gins H3-150 SSS Lab [200 Liter vessel -52.50 L ACN, 1 kg Amidite LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vvapor. FLV-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS-KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 16 - ------------------ Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: CA-Prop65/LIQUIDS Item CA~_#' : S~te. ·.<;on~%,. 'Mat':,~iac:·· .. ;·, Ha~rd Class · Sto~ge l,lniis l,J~~C,lc;,~,ed. 1'.ini~ Use-Ope11. 'l,lnits' 'Lc;,'<at!~n. · .---,,-- 51 2001-000-397 L 52 2001-000-397 L 100 Amidite Solution [95% Acetonitrile/75-05-8, 5% FL 1 B, IR, OHH, Deoxynucleoside Phosphoramidite & P65 T etrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-O 2730 mg/kg; LC50 21,354 ppm] [LD50-O >1,000 mg/kg;] [HR: H2 F3] 100 Amidite Solution [95%Acetonitrile/75-05-8, 5% Deoxynucleoside Phosphoramidite & Tetrazole/288-94-8] [FP 42oF; BP 81oC] [LEL: 3; UEL: 16] [SG 0.786; VD 1.41] [LD50-O 2730 mg/kg; LC50 21,354 ppm] [LD50-O >1,000 mg/kg;] [HR: H2 F3] FL1B, IR, OHH, P65 0.0000 Gins 13.2000 Gins 0.0000 Gins 39.6000 Gins 0.0000 Gins H3-150 SSS Lab [50 Litervessel-8.75 LACN, 1 kg Amidite 0.0000 Gins H3-150 SSS Lab [150 Liter vessel-35.00 L ACN, 1 kg Amidite ,----;. -.. :._,~. ·,·····, ·, ·-:---:.·-~:·.-:-::-::---:·~\-::.·:,. :,-~:A( ·-1:QT,A!-:~ CA-P.rop65/LIQUID§:, .. · .. ·. ,. --)'_; .. ,.'c.,,-, ·. ,;,;·;. :;::·:: !{"l1t~!ris: ... :'° o.oop:o, Gin:~. :{.:'<;. AG~~~GATE TOTAL~ ·c~~~ro·· s~1Ll<ii16~1}/{}~ · . . .. ,... . ,P .... ,.·. ·rMy'.:_! , . ,,y:. LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vvapor. FLV-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 17 •. >' - ------------------ Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: Toxics/SOLIDS : \tern, ·_CA$#. S~te ;co,nc% Material, ,. ; ~ ' . '' : ' : , l~ ·~-O -~-, ':~· , .,n,~'.i j ' •. -, :· •-•, "" :• ,•••, \ V ,,, )'•,•,< ·, :.H~~rqqlass, Storage Units. U,se-Clp~.ed. Urii~ 1./~e-Qpel'!. ~.nits: __ !-oJ,i,tJ<i,~·-· ._._. . t :· :--.. 53 1310--73-2 s ,. • ... '.. ----t •,c< "---,-;,--,. -•• , ~ 100 Sodium Hydroxide [Caustic Soda] [NAOH] [Base/Alkaline] [Lewis Red Devil Lye Drain Opener] [APC Caustic Alkaline Cleaner] [APC 500 Heavy Duty Caustic Cleaner] [Cycle AL- 100] [LDLo-O >/=500 mg/kg] [RTECS# WB4900000] [HR: H3 R1 COR WR] ::::tr:j~:~2sou~. . ... f ·:· ·.~:~-:·-· CR,TX,WR1 ~ ,: . . .. : 4.2200 Lbs 0.0000 Lbs 0.0000 Lbs H3-151 Clev/Strip lab ,;-.~_"'/ ',. /: '4.2ZOO. _L;!>s. . 0:000.0 Lbs , : 0,0000 . E6s. · • ,· • : ·~ ~p~ ' ·. · · .. 4;2200· Lbs ,,1. ' ' '. " ~ •• 1•• ... LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vvapor. FLV-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 18 v-<"'~·.t - ---------------- Isis Pharmaceuticals Inc. -2282 Faraday Ave, Carlsbad, CA. East (New) H3 GMP Suite: Water Reactives 1/SOLIDS ''lt~rti ,CAS# , 4 ,. 0 • /; ' -·¥_ :._: ,',;. ~ ~ _, . , . S~te C~nc¼ !'Jl~tem1l. .· · .. : . ·· }.. 0-H~~~: Cl~ss: •' Sto'9,ge u.~its 'U!:!e-Close<f ·Unit~ :u~-~Qp~n;-, · Vnits,·. '1:.01,'~tiO!l" . , • •• l ' •• '. • • ' 54 1310-73-2 S 100 Sodium Hydroxide [Caustic Soda) [NAOH] [Base/Alkaline) [Lewis Red Devil Lye Drain Opener] [APC Caustic Alkaline Cleaner) [APC 500 Heavy Duty Caustic Cleaner) (Cycle AL- 100) [LDLo-O >/=500 mg/kg] [RTE CS# WB4900000) [HR: H3 R1 COR WR] CR, TX, WR1 4.2200 Lbs 0.0000 Lbs 0.0000 Lbs H3-151 Clev/Strip lab ;_~Q!~~t: Wa~er :R~:~-~tives::1,scii.!PS :. · : : _ :· . _ ..... , , ~-~zOf · Lb~ " ,: .. ,, :· .. (.2:zoli: -Ll:!!i·· :'0·:~oo~"':t~i:::·: ;-~_::ff0ff\1t~;_. ·f.-GGRE~lffET<;?TAL-VVater B,e~ctiyes·11s9p1?,~;-:,;~'.,: . ,. ;', ~ ,.. ~· LEV: Local or general/area exhaust ventilation required for Class I, II and Ill-A Liquids use-open conditions. CLV-Combustible Liquid Vvapor. FLV-Flammable Liquid Vapor. Storage Amount = Maximum/total amount in use and storage, unless otherwise noted. Automatic fire sprinkler system protection. ,• ···1,. ,_ • . ' ., ... ~ ' '.J-f HAZARDOUS MATERIALS/OCCUPANCY CLASSIFICATION ANALYSIS -KLAUSBRUCKNER & ASSOC. -5/27/2008 -PAGE 19 -:, - ~-~. - ·, ~ '· ·-t' ,: . ,' -~~ .. ' - I I I I I I I I ,1 I I I I I I I I Class AL1 AL2 AL3 CA CD CF CL2 CL3A CL3B CR EX FG FL1A FL1B FL1C FS HT IR NH OHH OP1 OP2 OP3 OP4 ox OX1 OX2 OX3 OX4 PY RAD RADA RADB RADG SN TX UR1 UR2 UR3 UR4 WR1 WR2 WR3 OP CRY-NH CRY-F CRY-OX OP5 CL2-NFP CL3A-NFP CL3B-NFP Hazardous Materials Classification Definitions Name Aerosols Level 1 Aerosols Level 2 Aerosols Level 3 Carcinogens Combustible Dusts Combustible Fibers Combustible Liquids II Combustible Liquids Ill-A Combustible Liquids 11I-B Corrosives Explosives Flammable Gases Flammable Liquids I-A Flammable Liquids I-B Flammable Liquids I-C Flammable Solids Highly Toxics Irritants Nonhazardous Materials Other Health Hazards Organic Peroxides I Organic Peroxides II Organic Peroxides Ill Organic Peroxides IV Oxidizer Gases Oxidizers 1 Oxidizers 2 Oxidizers 3 Oxidizers 4 Pyrophorics Radioactive Radioactive -Alpha Radioactive -Beta Radioactive -Gamma Sensitizers Toxics Unstable Reactives 1 Unstable Reactives 2 Unstable Reactives 3 Unstable Reactives 4 Water Reactives 1 Water Reactives 2 Water Reactives 3 Organic Peroxides -Unclassified Detonable Cryogenic Liquids -Non Hazardous Cryogenic Liquids -Flammable Cryogenic Liquids -Oxidizing Organic Peroxides V Combustible Liquids II-No Fire. Point Combustible Liquids Ill-A-No Fire Point Combustible Liquids I11-B-No Fire Point I * California Fire Code Heaith or Physical Hazards I Page 20 Hazard* p p p H p p p p p H p p p p p p H H H p p p p p p p p p p H H H H H H p p p p p p p p p p p p p p p I I I I I I I I I I I I I I I I I I I Hazardous Materials Classification Definitions Class Name FL1A-NFP Flammable Liquids I-A-No Fire Poin~ FL 18-NFP Flammable Liquids I-B-No Fire Point FL 1C-NFP Flammable Liquids ·I-C-No Fire Point CA-CP Carcinogens-Consumer Products IR-CP Irritants-Consumer Products OHH-CP Other Health Hazards-Consumer Products SN-CP Sensitizers-Consumer Products SIED Special Industrial Explosive Devices P65 CA-Prop65 PSM PSM-OSHA RMP-T1 RMP Table1/Federal Regulated Substances RMP-T2 RMP Table2/Federal Regulated Flammable Substances RMP-T3 RMP Table3/CA Regulated Substances FRS Federal Regulated Substances FRF Federal Regulated Flammable Substances SRS State ReQulated Substances * California Fire Code He~lth or Physical Hazards Page 21 Hazard* p p p H H H H p I- I I I I I I I I I I I I I I I I I I 2007 CALIFORNIA CODE ANALYSIS -HAZARDOUS MATERIALS DEFINITIONS ACID + Corrosive material whose water solutions contain hydrogen ions. + Will liberate hydrogen gas on contact with certain metals. + Forms a salt when it reacts with a base. + Tastes sour. + Turns blue litmus paper red. + Very chemically active. + Burn, irritate or destructively attack organic tissue such as the skin, lungs, stomach. + Generally incompatible with bases [alkalis]. + pH = </=1 to <7 AEROSOL + A product that is dispensed from an aerosol container by a propellant. • Level 1 Aerosol: Chemical heat of combustion </=8,600 Btu/lb. • Level 2 Aerosol: Chemical heat of combustion >8,600 Btu/lb and <13_..,000 Btu/lb. • Level 3 Aerosol: Chemical heat of combustion >13,000 Btu/lb AEROSOL CONTAINER + A metal can, up.to a maximum size of 33.8 fluid ounces (1,000 ml}, designed to dispense an aerosol product; or + A glass or plastic bottle, up to a maximum size of 4 fluid ounces (118 ml), designed to dispense an aerosol product. BASE [ALKALI] + Corrosive materials whose water solutions contain hydroxyl ions. + Chemically opposite of an organic acid. + Forms a salt when it reacts with an acid. + Neutralizes acids. + Very chemically active. + Burn, irritate or destructively attack organic tissues such as skin, lungs, stomach. + pH= >7 to >/=14 CARCINOGEN + Substance that causes the development of cancerous growths in living tissue. + Chemical is considered to be a carcinogen if: • It has been evaluated by the International Agency of Research on Cancer (IRAC) and found to be a carcinogen; or • It is listed as a carcinogen or potential carcinogen in the Annual Report on Carcinogens published by the National Toxicology Program; or • Regulated by OSHA as a carcinogen .. CLOSED CONTAINER + A container sealed by means of a lid or other device such that liquid, vapor or dusts will not escape from it under ordinary conditions of use or handling. CLOSED SYSTEM + The use of a solid or liquid hazardous materials involving a closed vessel or system that remains closed during normal operations where vapors emitted by the product are not liberated outside of the vessel or system. + The product is not exposed to the atmosphere during normal operations. + Examples: • All compressed gases. • Product conveyed through a piping system into a closed vessel, system or piece of equipment. Klausbruckner & Associates Page 22 4015 Sorrento Valley Blvd., San Diego, CA 92121 I I I I I I I I I I I I I I I I I I I 2007 CALIFORNIA CODE ANALYSIS-HAZARDOUS MATERIALS DEFINITIONS COMBUSTIBLE DUST + Finely divided solid materials which is </=420 microns in diameter and which, when dispersed in air in the proper proportions, could be ignited by a flame, spark or other source ignition. + Combustible dust will pass through a U.S. No. 40 standard sieve. + Generally: · • Particulate from wood sanding and grinding is "Combustible Dust." • Particulate from wood routing is not "Combustible Dust." • Particulate from wood saving may or may not be "Combustible Dust." COMBUSTIBLE LIQUID + A liquid having a closed up flash point >/=100oF. • Class II Combustible Liquid: Flash point >/=100oF and <140oF. • Class IIIA Combustible Liquid:: Flash point >/=140oF and <200oF. • Class 11IB Combustible Liquid:: Flash point >/=200oF. + DOT Class 3 Materials. COMPRESSED GAS + A material, or mixture of materials which: • Is a gas 6BoF or less at 14.7 psia of.pressure; and • Has a boiling point of 68oF or less at 14. 7 psia which is either liquefied, non liquefied or in solution, except those gases which have no other health-or physical-hazard properties are not considered to be compressed until the pressure in the packaging exceeds 41 psia at 68oF. + The states of a compressed gas are categorized as follows: • Non liquefied Compressed Gases: Gases, other than those in solution, which are in a packaging under the charged pressure and are entirely gaseous at a temperature of 68oF. • Liquefied Compressed Gases: Gases that, in a packaging under the charged pressure, are partially liquid at temperature of 68oF • Compressed Gases in Solution: Nonliquefied gases that are dissolved in a solvent. • Compressed Gas Mixtures: Mixture of two or more compressed gases contained in a packaging, the hazard properties of which are represented by the properties of the mixture as a whole. CONTROL AREA + Spaces within a building where quantities of hazardous materials not exceeding the maximum allowable quantity per control area are stored dispensed, used or handled. + See also the definition of "Outdoor control area." CORROSIVE + A chemical that causes visible destruction of, or irreversible alterations in, living tissue by chemical action at the point of contact. + Test Data -DOTn 49 CFR 173.137: chemical destroys or changes irreversibly the structure of the tissue at the point of contact on albino rabbits following an exposure period of 4 hours. + Burns·or destructively attacks organic tissues such as the skin, lungs, stomach -i.e.: acids, bases, caustics. + General "rule of thumb": pH </=2-3 and >/=12 + Dot Class 8 Materials. CRYOGENIC FLUID + A fluid having a boiling point lower than -130oF at 14.7 psia. FLAMMABLE GAS + A material which is a gas at 6BoF or less at 14.7 psia which: • Is ignitable at 14.7 psia when in a mixture of </=13% by volume with air; or • Has a flammable range at 14.7 psia with air of at least 12%, regardless of lower limit. + The limits specified shall be determined at 14.7 psi of pressure and a temperature of 68oF. + DOT Class 2 Materials. FLAMMABLE LIQUEFIED GAS + A liquefied compressed gas which, under a charged pressure, is partially liquid at a temperature of 68oF and which is flammable. · Klausbruckner & Associates Page 23 4015 Sorrento Valley Blvd., San Diego, CA 92121 I I I I I I I I I I I I I I I, I I I I 2007 CALIFORNIA CODE ANALYSIS -HAZARDOUS MATERIALS DEFINITIONS FLAMMABLE LIQUID + A liquid having a closed cup flash point <100oF. • Class IA Flammable Liquid: Flash point <73oF and boiling point <100oF. • Class IB Flammable Liquid: Flash point <73oF and boiling point >/=100oF. • Class II Flammable Liquid: Flash point >/=73oF and <100oF. + DOT Class 3 Materials. FLAMMABLE MATERIAL + A material capable of being readily ignited from common sources of heat or at a temperature of 600oF or less. FLAMMABLE SOLID + A solid, other than a blasting agent or explosive, that is capable of causing fire through friction, absorption or moisture, spontaneous chemical change, or retained heat from manufacturing or processing, or + A solid which has an ignition temperature below 212oF which burns so vigorously and persistently when ignited as to create a serious hazard. + Test' Data -CPSC 16 CFR; Part 1500.44: a chemical that ignites and burns with a self-sustained flame at a rate greater than 0.1 inch per second along its major axis. + DOT Class 4.1 Materials. FLAMMABLE VAPORS OR FUMES + The concentration of flammable constituents in air that exceeds 25 percent of their lower flammable limit (LFL). HAZARD RATING [DEGREES OF HAZARD] + Health [Blue]: Hazard rating of health hazards ranked according to the probably severity of the effects of exposure to personnel as follows: • 4: Materials that on very short exposure could cause death or serious residual injury, including those too dangerous to be approached without specialized protection equipment-i.e.: * Inhalation/Absorption -Skin: Materials that, under normal conditions or under fire conditions, are extremely hazardous through inhalation of through contact with or absorption by the skin. * Ingestion -Oral: Materials whose LD50 for acute oral toxicity is </= 5 milligrams per kilogram [mg/kg]. * Skin: Materials whose LOSO for acute dermal toxicity is </=40 milligrams per kilogram [mg/kg]. * Dusts & Mists -Inhalation: Dusts & mists whose LC50 for acute inhalation toxicity is </=0.5 milligrams per liter [mg/L). * Liquids -Inhalation: Liquid whose saturated vapor concentration at 20oC is >/= 1 0 times its LC50 for acute inhalation toxicity, if its LC50 is </=1,000 parts per million [ppm]. * Gases -Inhalation: Gas whose LC50 for acute inhalation toxicity is </=1,000 parts per million [ppm). • 3: Materials that on short exposure could cause serious temporary or residual injury, including those requiring protection from all bodily contact -i.e.: * Combustion Products: Materials that give off highly toxic combustion products. * Ingestion -Oral: Materials whose LD50 for acute oral toxicity is >5 milligrams and </=50 milligrams per kilogram [mg/kg). * Skin: Materials whose LD50 for acute dermal toxicity is >40 milligrams and </=200 milligrams per kilogram [mg/kg). * Dusts & Mists -Inhalation: Dusts & mists whose LC50 for acute inhalation toxicity is >0.5 and </=2 milligrams per liter [mg/L). * Liquids -Inhalation: Liquid whose saturated vapor concentration at 20oC is >/= its LC50 for acute inhalation toxicity, if its LC50 is </=3,000 parts per million [ppm] and does not meet the criteria for degree of hazard 4. * Gases -Inhalation: Gas whose LC50 for acute inhalation toxicity is >1,000 and <3,000 parts per million [ppm]. * Corrosive: Materials that are either severely corrosive to skin on single, short exposure or cause irreversible eye damage. • 2: Materials that on intense or short exposure could cause temporary incapacitation or possible residual injury, including those requiring the use of respiratory protective equipment that has an independent air supply -i.e.: * Combustion Products: Materials that emit toxic or highly toxic irritating combustion products. * Lack of Warning Properties: Materials that, under normal conditions or fire conditions, give off toxic vapors that lack warning properties. · * Ingestion -Oral: Materials whose LD50 for acute oral toxicity is >50 milligrams and </=500 milligrams per kilogram [mg/kg). Klausbruckner & Associates Page 24 4015 Sorrento Valley Blvd., San Diego, CA 92121 I I I e I I I I I I I I I I I I I I I 2007 CALIFORNIA CODE ANALYSIS -HAZARDOUS MATERIALS DEFINITIONS HAZARD RATING [DEGREES OF HAZARD]-continued + Health [Blue] -continued: * Skin: Materials whose LD50 for acute dermal toxicity is >200 milligrams and </=1,000 milligrams per kilogram [mg/kg). * Dusts & Mists -Inhalation: Dusts & mists whose LC50 for acute inhalation toxicity is >2 and </=1 0 milligrams per liter [mg/LJ. * Liquids -Inhalation: Liquid whose saturated vapor concentration at 20oC is>/= 1/5 its LC50 for acute inhalation toxicity, if its LC50 is </=5,000 parts per million [ppm] and does not meet the criteria for degree of hazard 3 or 4. * Gases • Inhalation: Gas whose LC50 for acute inhalation toxicity is >3,000 and </=5,000 parts per million [ppm). . * Irritant: Materials that cause severe but reversible respiratory, skin or eye irritation. . • 1: Materials that on exposure could cause irritation but only minor residual injury, including those requiring the use of an approved air-purifying respirator -i.e.: * Combustion Products: Materials that emit irritating combustion products. * Fire Conditions: Materials that, under fire conditions, cause skin irritation, but not destruction of tissue. * Ingestion· Oral: Materials whose LOSO for acute oral toxicity is >500 milligrams and </=2,000 milligrams per kilogram (mg/kg). * Skin: Materials whose LD50 for acute dermal toxicity is >1,000 milligrams and </=2,000 milligrams per kilogram [mg/kg). * Dusts & Mists -Inhalation: Dusts & mists whose LC50 for acute inhalation toxicity is >10 and </=200 milligrams per liter [mg/L]. * Gases & Vapors -Inhalation: Gas & vapor whose LC50 for acute inhalation toxicity is >5,000 and </=10,000 parts per million [ppm). * Irritant: Materials that are moderate respiratory irritants, or that cause slight to moderate eye irritation. • 0: Materials that on exposure under fire conditions would offer no hazard beyond that of ordinary combustible materials-i.e.: * Ingestion • Oral: Materials whose LOSO for acute oral toxicity is >2,000 milligrams per kilogram [mg/kg]. * Skin: Materials whose LOSO for acute dermal toxicity is >2,000 milligrams per kilogram [mg/kg). * Dusts & Mists -Inhalation: Dusts & mists whose LC50 for acute inhalation toxicity is >200 milligrams per liter [mg/L). * Gases & Vapors -Inhalation: Gas & vapor whose LC50 for acute inhalation toxicity is >10,000 parts per million [ppm]. • Flammability [Red]: Hazard rating of flammability hazards ranked according to the susceptibility of materials to burning as follow: • 4: Materials that will rapidly or completely vaporize at atmospheric pressure and normal ambient temperature or that are readily dispersed in air, and which will burn readily --i.e.: * Flammable Gases. * Flammable cryogenics. * Any liquid or gaseous material that is liquid while under pressure and has a flash point <73oF and a boiling point <100oF [i.e.: Class I-A Flammable Liquid). * Materials that ignite spontaneously when exposed to air [i.e.: Pyrophorics]. • 3: Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials in this degree produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions --i.e.: * Liquids having a flash point <730F and having a boiling point >/=1 00oF and those liquids having a flash point >/=73oF and <100oF (i.e.: Class 1-B & 1-C Flammable Liquids]. * Materials that on account of their physical form or environmental conditions can form explosive mixtures with air that are readily dispersed in air [i.e.: dusts of combustible/flammable solids, mists of flammable/combustible liquid droplets]. * Materials that burn with extreme rapidity, usually by reason of self-contained oxygen [i.e.: many Organic Peroxides, dry nitrocellulose]. • 2: Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials in this degree would not under normal conditions form hazardous atmospheres with air, but under ambient temperatures or under moderate heating may release vapor in sufficient quantities to produce hazardous atmospheres with air --i.e. * Liquids having a flash point >100oF and </-200oF [i.e.: Class II & Class Ill-A Combustible Liquids]. * Solid materials in the form of coarse dusts that may burn rapidly but that generally do not form explosive atmospheres with air [i.e.: Flammable Solids]. * Solid materials in a fibrous or shredded form that may burn rapidly and create flash fire hazards [i.e.: cotton, sisal, hemp]. * Solids and semisolids that readily give off flammable vapors. Klausbruckner & Associates 4015 Sorrento Valley Blvd., San Diego, CA 92121 Page 25 I I I I I I I I I I I I I I I I- I I I 2007 CALIFORNIA CODE ANALYSIS -HAZARDOUS MATERIALS DEFINITIONS HAZARD RATING [DEGREES OF HAZARD]-continued + Flammability [Red] -continued: • 1: Materials that must be preheated before ignition can occur. Materials in this degree require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur -i.e.: * Materials that will burn in air when exposure to a tempura of 1500oF for </=5 minutes. * Liquids, solids & semisolids having a flash point >200oF [i.e.: Class 111-8 Combustible Liquids). • O: Materials that will not burn --i.e.: material that will not burn in air when exposed to a temperature of 1500oF for a period of 5 minutes. + Reactivity/Instability [Yellow]: Hazard rating of reactivity [instability] hazards ranked according to ease, rate and quantity of energy release as follows: • 4: Materials that in themselves are readily capable of detonation or explosive decomposition or explosive reaction at normal temperatures and pressures -i.e.: * Materials sensitive to localized thermal or mechanical shock at normal temperatures and pressures. • 3: Materials that in themselves are capable of detonation or explosive decomposition or explosive reaction, but that require a strong initiating source or that must be heated under confinement before initiation --i.e.: * Materials sensitive to thermal or mechanical shock at elevated temperatures and pressures. * Materials that reactive explosively with water without requiring heat or confinement. • 2: Materials that readily undergo violent chemical change at elevated temperatures and pressures --i.e.: * Materials that exhibit an exotherm at temperatures </=150oC when tested by differential scanning calorimetry. · * Materials that may react violently with water or form potentially explosive mixtures with water. • 1: Materials that in themselves are normally stable, but that can become unstable at elevated temperatures and pressure --i.e.: * Materials that change or decompose on exposure to air, light or moisture. * Materials that exhibit an exotherm at temperatures >150oC but </=300oC when tested by differential scanning calorimetry. • O: Materials that in themselves are normally stable, even under fire conditions --i.e.: * Materials that do not react with water. * Materials that exhibit an exotherm at temperatures >300oC but </=500oC when tested by differential scanning calorimetry. * Materials that do not exhibit an exotherm at temperature </=500oC when tested by differential scanning calorimetry. HAZARDOUS MATERIALS + Chemicals or substances which are physical hazards or health hazards as defined and classified in IFC/CFC Chapter 27, whether the materials are in usable or waste condition. HEAL TH HAZARD + A classification of a chemical for which there is statistically significant evidence that acute or chronic health effects are capable of occurring in exposed persons. Highly toxic and toxic materials. Corrosive materials. HIGHLY TOXIC + Material which produces a lethal dose or lethal concentration as follows: • . Oral Ingestion = LD50 = </=50 mg/kg -Rat: Median lethal dose [LD50] of 50 milligrams of less per kilogram of body weight when administered orally to albino rats weighing between 200 and 300 grams each. • Skin Absorption = LD50 = </=200 mg/kg -Rabbit: Median lethal dose [LD50] of 200 milligrams or less per kilogram of body weight when administered by continuous contact for 24 hours (or less if death occurs within 24 hours) with the bare skin of albino rabbits weighing between 2 and 3 kilograms each. • Inhalation = LC50 = </=200 ppm -Rat: Median lethal concentration [LC50] in air of 200 ppm by volume or less of gas or vapor, or 2 milligrams per liter or less of mist, fume or dust, when administered by continuous inhalation for one hour (or less if death occurs within 1 hour) to albino rats weighing between 200 and 300 grams each. • Mixtures of these materials with ordinary materials, such as water, might not warrant classification as highly toxic. + Dot Class 6.1 Materials. Klausbruckner & Associates Page 26 4015 Sorrento Valley Blvd., San Diego, CA 92121 I I I I I I I I I I I I I I I I I 2007 CALIFORNIA CODE ANALYSIS -HAZARDOUS MATERIALS DEFINITIONS INCOMPATIBLE MATERIALS + Materials that, when mixed, have the potential to react in a manner which generates heat, fumes, gases, or byproducts which are hazardous to life or property. + The maximum allowable quantity per control area is based on the material state (solid, liquid or gas) and the material storage or use conditions. IRRITANT + A chemical which is not corrosive, but which causes a reversible inflammatory effect on living tissue by chemical action at the site of contact. + A chemical is a skin irritant if, when tested on the intact skin of albino rabbits by the methods of CPSC 16CFR Part 1500.41 for an exposure of four or more hours or by other appropriate techniques, it results in an empirical score of 5 or more. + A chemical is classified as an eye irritant if so determined under the procedure listed in CPSC 16CFR Part 1500.42 or other approved techniques. LIQUEFIED PETROLEUM GAS (LP-gas) + A material which is composed predominantly of the following hydrocarbons or mixtures of them: . propane, propylene, butane (normal butane or isobutene) and butylenes. LOWER FLAMMABLE LIMIT (LFL) + The minimum concentration of vapor in air at which propagation ·of flame will occur in the presence of an ignition source. + The LFL is sometimes referred to as LEL or lower explosive limit. MAXIMUM ALLOWABLE QUANTITY PER CONTROL A~EA (MAQ) + The maximum amount of a hazardous material allowed to be stored or used within a control area inside a building or an outdoor control area. OCCUPANCY + B Occupancy: Business Group B occupancy includes, among others, the use of a building or structure, or portion thereof, for office, professional or service-type transaction, laboratories (testing and research), and print shops. + F Occupancy: Factory Industrial Group F occupancy includes, among others, the use of a building or structure, or a portion thereof, for assembling, disassembling, fabricating, finishing, manufacturing, packaging, repair or processing operations that are not classified as Group H high-hazard or Group S storage occupancy. • F-1 Moderate-hazard Occupancy: Includes, but not limited to, athletic equipment, automobiles, electronics, food processing, laundries, paper mills, printing and publishing, soaps and detergents, textiles and wood. • F-2 Low-hazard Occupancy: Factory industrial uses involving the fabrication or manufacturing of noncombustible materials which, during finishing, packaging or processing do not involve a significant fire hazard. + H Occupancy: High-hazard Group H occupancy includes, among others, the use of a building or structure, or a portion thereof, that involves the manufacturing, processing, generation or storage of materials that constitute a physical or health hazard in quantities in excess of quantities allowed in control areas constructed and located as required in Section 2703.8.3. • H-2: >/= Maximum Allowable Quantity of one or more of the following Physical Hazard Materials: • Class I, II or IIA flammable or combustible liquids used or stored in normally open containers or systems, or in closed containers or systems pressurized at >15 psig. • Combustible dust. • Cryogenic fluids, flammable. Flammable gases. • Class 1 organic peroxides. • Class 3 oxidizers used or stored in normally open containers or systems, or in closed containers or systems pressurized at >15 psig. • Pyrophoric liquids, solids and gases, nondetonable. • Class 3 nondetonable unstable (reactive) materials. • Class 3 water reactive materials. Klausbruckner & Associates Page 27 4015 Sorrento Valley Blvd., San Diego, CA 92121 I I I I I I I I I I I I I I I I I I I 2007 CALIFORNIA CODE ANALYSIS -HAZARDOUS MATERIALS DEFINITIONS OCCUPANCY -continued • H-3: >/= Maximum Allowable Quantity of one or more of the following Physical Hazard Materials: • Class I, II or IIA flammable or combustible liquids used or stored in normally open containers or systems, or in closed containers or systems pressurized at >15 psig. Combustible fibers, other than densely packed baled cotton. • Oxidizing Cryogenic fluids. • Flammable solids. Class II and Ill Organic peroxides. • Class 2 Oxidizers. • Class 2 Oxidizers used or stored in normally open containers or systems, or in closed containers or systems pressurized at >15 psig. • Class 2 unstable (reactive) materials. • Class 2 water-reactive materials. • H-4: >/= Maximum Allowable Quantity of one or more of the following Health Hazard Materials: • Corrosives. • Highly toxic materials. • Toxic materials. + M Occupancy: Mercantile Group M occupancy includes, among others, buildings and structures or a portion thereof, for the display and sale of merchandise, and involves stocks of goods, wares or merchandise incidental to such purposes and accessible to the public. • S Occupancy: Storage Group S occupancy includes, among others, the use of a building or structure, or a portion thereof, for storage that is not classified as a hazardous occupancy. • S-1 Moderate-hazard storage: Includes, but not limited to, level 2 and 3 aerosols, books and paper in rolls or packs, cardboard boxes, clothing, glues, motor vehicle repair garages, and soaps. • S-2 Low-hazard storage: Buildings used for the storage of noncombustible materials such as products on wood pallets or in paper cartons with or without single thickness divisions; or in paper wrappings. OPEN SYSTEM • The use of a solid or liquid hazardous materials involving a vessel or system that is continuously open to the atmosphere during normal operations and where vapors are liberated, or the product is exposed to the atmosphere during normal operations. • Examples: . • Dispensing from or into open beakers or containers. • Dip tank and plating tank operations. ORGANIC PEROXIDE + An organic compound that contains the bivalent -0-0-structure and which may be considered to be a structural derivative of hydrogen peroxide where one or both of the hydrogen atoms have been replaced by an organic radical. • Organic peroxides can present an explosion hazard {detonation or deflagration) or they can be shock sensitive. • Organic peroxides can decompose into various unstable compounds over an extended period of time. • DOT 5.3 Materials. • Unclassified Detonable Organic Peroxide: • Organic peroxides that are capable of detonation. There peroxides pose an extremely high- explosion hazard through rapid explosive decomposition. • Regulated as Class A explosive • DOTTypeA • Class I Organic Peroxide: • Formulations that are capable of deflagration but not detonation. • DOT Type B • Class II Organic Peroxide: • Formulations that burn very rapidly and that pose a moderate reactivity hazard. • DOT Type C • Class Ill Organic Peroxide: • Formulations that burn rapidly and that pose a moderate reactivity hazard. • DOT Type D • Class IV Organic Peroxide: • Formulations that burn in the same manner as ordinary combustibles and that pose a minimal reactivity hazard. • DOT Type E & F Klausbruckner & Associates Page 28 4015 Sorrento Valley Blvd., San Diego, CA 92121 I I I I I I I: I I I I I I I I I 2007 CALIFORNIA CODE ANALYSIS -HAZARDOUS MATERIALS DEFINITIONS ORGANIC PEROXIDE • continued • Class V Organic Peroxide: • Formulations the burn with less intensity than ordinary combustibles or do not sustain combustion and that pose no reactivity hazard. • DOT Type G OTHER HEAL TH HAZARD + Hazardous material which affects target organs of both body including, but not limited to, those materials which produce liver damage, kidney damage, damage to the nervous system, act on the blood to decrease hemoglobin function, deprive the body tissue of oxygen, or affect reproductive capabilities including mutations [chromosomal damage] or teratogens [effects on fetuses]. OUTDOOR CONTROL AREA + An outdoor area that contains hazardous materials in amounts not exceeding the maximum allowable quantities of Table 2703.1.1 (3) or 2703.1.1 (4). OXIDIZER pH + A material that readily yields oxygen or other oxidizing gas, or that readily reacts to promote or initiate combustion of combustible materials. + Examples of other oxidizing gases include bromide, chlorine and fluorine. + DOT Class 5.1 Materials. • Class 4 Oxidizer: • Can undergo an explosive reaction due to an explosive reaction due to contamination or exposure to thermal or physical shock. • Will enhance the burning rate and can cause spontaneous ignition of combustible. • Acceptable Test Criteria -DOT Packaging Group I: Material which, in either concentration tested, exhibits a burning time equal to or less than that of potassium bromate. • Class 3 Oxidizer: · • Will cause a severe increase in the burning rate of combustible materials with which it comes in contact or will undergo vigorous self-sustained decomposition caused by contamination or exposure to heat. • Acceptable Test Criteria -DOT Packaging Group II: Material, which, in either concentration tested, exhibits a burning time between that of potassium bromate and that of potassium perchlorate. · • Class 2 Oxidizer: • Will cause a moderate increase in the burning rate of that causes spontaneous ignition of combustible materials with which it comes in contact. • Acceptable Test Criteria -DOT Packaging Group Ill: Material, which, in either concentration tested, exhibits a burning time between that of potassium perchlorate and that of ammonium persulphate. • Class 1 Oxidizer: • Primary hazard is that it slightly increases the burning rate but which does not cause spontaneous ignition when it comes in contact with combustible materials. + Value used to represent the strength of an acid or base [alkali]: • pH 1-<7: Acid [1=Strong; 6=Weak] • pH 7: Neutral [i.e. Water] · • pH >7-14: Base [pH 11 = 10 times more corrosive than pH of 10] • Skin: ph 6-8 PHYSICAL HAZARD + Explosive and blasting agents. + Flammable and combustible liquids. + Flammable solids and gases. + Organic peroxide materials. + Oxidizer materials. + Pyrophoric materials. + Unstable (reactive) materials. + Water-reactive solids and liquids. + Cryogenic fluids. Klausbruckner & Associates 4015 Sorrento Valley Blvd., San Diego, CA 92121 Page 29 I I I I I I I I I I I I I I· I I 2007 CALIFORNIA CODE ANALYSIS -HAZARDOUS MATERIALS DEFINITIONS PYROPHORIC + A chemical with an auto-ignition temperature in air, at or below a temperature of 130oF. SENSITIZER + Chemical that causes a substantial proportion of exposed people or animals to develop an allergic reaction in normal tissue after repeated exposure to the chemical. + Chronic effect/reaction. STORAGE + The keeping, retention or leaving of hazardous materials in closed containers, tanks, cylinders, or similar vessels; or vessels supplying operations through closed connections to the vessel. TOXIC MATERIAL + Materials which produces a lethal dose or lethal concentration as follows: • Oral Ingestion = LD50 = >50 mg/kg to 500 mg/kg -Rat: Median lethal dose [LD50] of more than 50 milligrams per kilogram, but not more than 500 milligrams per kilogram of body weight when administered orally to albino rats weighing between 200 and 300 grams each. • Skin Absorption = LD50 = >200 mg/kg to 1,000 mg/kg -Rabbit: Median lethal dose [LD50] of more than 200 milligrams per kilogram of body weight when administered by continuous contact for 24 hours (or less if death occurs within 24 hours) with the bare skin of albino rabbits weighing between 2 and 3 kilograms each. • Inhalation= LC50 = >200 ppm to 2,000 ppm -Rat: Median lethal concentration [LC50] in air of more than 200 ppm but not more than 2,000 ppm by volume of gas or vapor, or more than 2 milligrams per liter but not more than 20 milligrams per liter of mist, fume or dust, when administered by continuous inhalation for 1 hour (or less if death occurs within 1 hour) to albino rats weighing between 200 and 300 grams each. + Mixtures of these materials with ordinary materials, such as water, might not warrant classification as toxic. + DOT Class 6.1 Materials. UNSTABLE (REACTIVE) MATERIAL + A material, other than an explosive, which in the pure state or as commercially produced, will vigorously polymerize, decompose, condense or become self-reactive and undergo other violent chemical changes, including explosion, when exposed to heat, friction or shock, or in the absence of an inhibitor, or in the presence of contaminants, or in contact with incompatible materials. + Unstable (reactive) materials are subdivided as follows: • Class 4 Unstable (Reactive): • Capable of detonation, explosive decomposition or explosive reaction at NTP. • Materials that are sensitive to mechanical or localized thermal shock at NTP. • Class 3 Unstable (Reactive): • Capable of detonation, explosive decomposition or explosive reaction but which require a strong initiating source or which must be heated under confinement before initiation. • Materials that are sensitive to thermal or mechanical shock at elevated temperature and pressures. • Class 2 Unstable (Reactive): • Normally unstable and readily undergo violent chemical change but do not detonate. • Materials that can undergo chemical change with rapid release of energy at NTP. • Materials that can undergo violent chemical change at elevated temperatures and pressures. • Class 1 Unstable (Reactive): • Materials that are normally stable but which can become unstable at elevated temperature and pressures. USE (MATERIAL) + Placing a material into action, including solids, liquids and gases. Klausbruckner & Associates Page 30 4015 Sorrento Valley Blvd., San Diego, CA 92121 I I I I I I I I I I 1. I I I I I I 2007 CALIFORNIA CODE ANALYSIS -HAZARDOUS MATERIALS DEFINITIONS WATER REACTIVE MATERIAL • A material that explodes; violently reacts; produces flammable, toxic or other hazardous gases; or evolves enough heat to cause auto-ignition or ignition of combustibles upon exposure to water or moisture. • DOT Class 4.3 Materials. • Class 3 Water Reactive: • Materials that react explosively with water without requiring heat or confinement. • Class 2 Water Reactive: • Materials that react violently with water or have the ability to boil water. • Materials that produce flammable, toxic or other hazardous gases, or evolve enough heat to cause auto-ignition or ignition of combustibles upon exposure to water or moisture. • Class 1 Water Reactive: • Materials that react with water with some release of energy, but not violently. Klausbruckner & Associates Page 31 4015 Sorrento Valley Blvd., San Diego, CA 92121 SAN DIEGO .REGIONAL HAZARDOUS MATERIALS QUESTIONNAIRE ' Business Conlacl ~I< "w\..~.\c_ City State ~ OFFICE USE ONLY UPFH ______ _ HVI _______ _ BPDATE / / PlanFiletl The followlng queatlons repruent Ille facRlly'a activities, NOT the speGffic project description, PART I: FIRE DEPARTMENT-HAZARDOUS MATERIALS DlVJSJON: OCCcf ANCY CLASSIFICATION: Indicate by clrcllng the Item, whether your business will use. process, or stoJB any of the foilowing hazardous materfals. If any the Hems are-ciR:led, applicant must contact the Fire f'mtectlon Agency With jurlsdk:llon prior to plan sUllmlttal. · Exploslw or Blaslfng Agents 5. Organic Peroxides 9; water Reactiws . (D;>corrostves compressed Gases 6. Oxidizers 10. Ctyosenk:s 14. Olher Health Hazards . lammable/COmbustlbJe Liquids 7. Pyrophorics <rb Highly TOldc or Toxic Materials 15. None of These. . 4. Flamma~le Solids • 8. Unstable Reacli~s 12. Radloacllvea questions is ~. a nt must eontact the cou call (619) 338-2222 prior to the Issuance of e bu FEES ARE REQUIRa>, ~ YES NO . 1. fi2I" D Is your business listed on the revetse side ofthls fonn? (check ag !hat apply). i. g"'.: O WID your business dlsJ10$8 (?f Hazardous Substances or Medical Waste Jn any amount? 3. g .0 WID your-business store or handle Hazardous SUIIStances In quantltles equal to or greater than _,. 55 gallons, 500 pounds, 200 cubic feet. or~rclnogerislreproducllve toxins In r,iny quantity? 4. • D DO. wm y1111r business use an existlng or Install an underground storage tank? 5. g,. g" Will your business store or handle Regulated SUbsjllnces (C81ARP)? 8. . m D . Will your business use qr lnstaU a Hazardous Waste Tank System (TIUe 22, Article 10}? p CalARP Exempt Date lnltfals 0 CalARP Requited I Date lnlllalll 0 CalARP Complete I Date lnffla!s ~Mlo~=c::OP&i'ti~ ~~c~ 1~~.t8,~1a~~~~~~~hi::~0:!;i~fS:W,re'i~:O~':cNur;~~in;J:'f: Ut~-l':i:ai:f~~~t .:!lf:t:'!':~~.!':w: permiL Note: If the answer to quesUons 3 or 4 Is yes, appUcant must also submit an asbestos noUficallon form to the APCD at least 10 working days prior lo commencing demollUon or renovation, except demolfflon or mnovaffcm of resldenllal structures of four unHs or Jess. Contact the APCD for moie lnfonnatlon. Y,!§, NO • . 1. e,r O wm the subjec:t faclllly or construction actMtfes Include OJ)eratlons or equipment thlit emit or are capable of emilllng an air contaminant? (See the APCD factsheet at http://www.sdapcd.org/lnfo/facls/pennhs.pdf, and tile 11st of typical equipment requiring an APCO pennlt on the reverse skfe ..../ of this from. Contact APCD If you have ii_ny qu~m). 2. O M (ANSWER GNL Y IF QUESTION 11S Yes) WIii the subject ra.:lffty be located within 1.000 feet of the outer br,undary of a schaol (K through 12)? (Publlc and private schools may be found afler search of the C811fomla School D118ctoiy at http;J/www.cde.ca.gov/tetsd/: or c:onlac:t tfie _/ appropriate school d!wict}. . . • • a. O ~Will there be renovaUon tliat fnvolves handling of any friable asbestos materials, or dlm11t1lng any material that contains nOO:frfable asbestos? 4. · D . M WID t.heJB be demolition rnvoMng the removal of a toad supporting slrui:tlital member? BllellY describe business actMlfe.s: Briefly describe proposed ·project M4ce,..,\¾u.t g ! t) .Xn~l\c:-n'b,,,... 6~ (;(.½c"'~ ~Jl ~-br~ ~ks I declare undeJ.penall)' of petJu,y !hat to the bes! of my knowledge and befief the~ made herein are true and correct. · ~,c.\l. w~;fL ~A-· Name of ~ner or Authorized Agent Signature of (?wner or.Authorized Agent lo I I"> /of!> Date ~~WJlxt-hYilr0~~LPANCYCLASSIFICATION:. ____________________________ _ B~------------------,-------OATE: _ __.I.__ _ _./:....-__ EXEMPT OR HOFUR'IHEltlNFORMAnoN KEQUIREO Ra.l!ASED FOR BULDING PERMITBUTHDTFOR OCCUPANOY RE1£ASED FOROCCUPANCV COUNlY-HMD APCD COUNJY-HMD APCD COUN'JY-HMD APCD . . . ·. . ' . , . HM•!ll?I (0~/06) County of Sllll Diego -DEH-Hamdous Materials Division Phone: 619 944 4107 Fax: 858 538 8486 www .blevinscubed.com From: "Hartn_ett, Gary" <Gary.Hartnett@sdcounty.ca.gov> Date: Mon, 27 Oct 2008 15:21 :27 -0700 To: <info@blevinscubed.com> Subject: Rule 11 Exemption Hi Lee, Page 2 of 3 Below is our Rule 11 exemption from District permit requirements we discussed over the phone. If you have any additional questions, please feel free to give me a call. Gary RULE 11. EXEMPTIONS FROM RULE 10 PERMIT REQUIREMENTS (Effective 1/1/69: Rev. Adopted & Effective 10/17/95 Rev. Adopted & Effective 7/30/96 Rev. Adopted & Effective 5/21/97 Rev. Adopted & Effective 11/15/00 Rev. Adopted & Effective 4/25/07 (4) LABORATORY EQUIPMENT AND RELATED OPERATIONS (i) Laboratory testing equipment and quality control testing equipment, used exclusively for chemical and physical analysis. (ii) Vacuum-producing devices used in laboratory operations. (iii) Hoods, stacks, or ventilators. (iv) Research and development equipment. (v) Peptide and DNA synthesis operations. (vi) Equipment used to manufacture: (A) biotechnology pharmaceutical products for exclusive use in federal Food and Drug Administration (FDA) approved clinical trials Gary M. Hartnett Air Quality Inspector Ill Compliance Division Air Pollution Control District file://C:\Documents and Settings~alta.CARLSBAD\Local Settings\Temp\XPgrpwi ... 10/27/2008 (858) 586-2671 Gary.Hartnett@sdcounty.ca.gov Celebrating 50 years of air quality progress! Page 3 of 3 file://C:\Documents and Settings~alta.CARLSBAD\Local Settings\Temp\XPgrpwi. .. 10/27/2008 STRUCTURAL CALCULATIONS For ISIS EXPANSION AND AUTOMATION Tl 1896 Rutherford Court, Carlsbad, California Prepared for Isis Pharmaceuticals 1896 Rutherford Road Carlsbad, CA 92008 Prepared by: DEVINE ENGINEERING, INC. 12316 Oak Knoll Road, Suite C Poway, CA 92064 (858)7 48-6168 May 30, 2008 Project Number: 1035.00 DEVINE ENGINEERING, INC. JOB: ISISA& E \ C)'3 S-OQ 12316 Oak Knoll Rd. Suite C SHEET NO. OF Poway, CA 92064 CALCULATED BY M<?-i DATE G:, ~4~o?:i ' Design Loads: Roof Dead Roof live Load Seisfllic Load Scope of Work (858) 748-6168 25psf 20 psf Sds 0.797 R 3 Precast Cone Panels I 1 Cs 0.2657 W LRFD Cs 0.186 W ASD (.7E) CHECKED BY DATE !) Cut (3) SMALL OPENINGS IN CONT CONCRETE PANEL WALL. BY INSPECTION OK FOR MINOR OPENINGS. 2) INSTALL (3) NEW MECH UNITS ON ROOF. Pmax=400# MAX EA INCLUDING CURBS. OK BY INSPECTION. 3) NEVI DRYER TO BE INSTALLED IN (E) MECHANICAL YARD Conterminous 48 States 2005 ASCE 7 Standard latitude = 33.1358 longitude = -117 .278 Spectral Response Accelerations Ss and S1 Ss and S1 = Mapped Spectral Acceleration Values Site Class B -Fa= 1.0 ,Fv = 1.0 Data are based on a 0.01 deg grid spacing Period Sa (sec) (g) 0.2 1.149 (Ss, Site Class B) 1.0 0.435 (S1, Site Class B) Conterminous 48 States 2005 ASCE 7 Standard Latitude = 33.1358 Longitude= -117.278 Spectral Response Accelerations SMs and SM 1 SMs = Fass and SM1 = FvS1 Site Class D -Fa = 1.04 ,Fv = 1.565 Period Sa (sec) (g) 0.2 1.195 (SMs, Site Class D) 1.0 0.681 (SM1, Site Class D) Conterminous 48 States 2005 ASCE 7 Standard Latitude = 33.1358 Longitude = -117.278 SDs = 2/3 x SMs and SD1 = 2/3 x SM1 Site Class D -Fa= 1.04 ,Fv = 1.565 Period Sa (sec) (g) 0.2 0.797 (SDs, Site Class D) .2irtek AIRTEK QUICK SPECS Page 1 of 1 ~~':::_~ ''---J,e~wX{~-~--;;;, , !Model II SC220 !capacity !1220 l!scFM 116.23 ,~ !Design Inlet Pressure 11100 IIPSIG 116.8 ,~ !Maximum Inlet Temperature !1100 IIF 1138 I@= !Maximum Ambient Temperature 11100 IIF 1138 I@= !Minimum Ambient Temperature !Maximum Pressure !Differential Pressure !Refrigeration Compressor !standard Electrics !Available KW !operating KW !standard Freon Type !condenser Cooling Type !Air In/Out Connections !water In/Out !Replacement Element I unit Length !unit Width !unit Height !Shipping Weight Previous _Model 1140 IIF II 4.4 I@= I 200 IIPSIG 1113.8 ,~ 4.3 IIPSIG 11 o.3 II§ 1 l!HP 208/230/1 I !Volts/Phase/Hz 111.8 ii 1.49 II R-134A II Air II 2· II Inches II N/A II Inches ( only applicable on water coo Next Model JE-C0200-30 47 l11nches 111194 II~ 22 II Inches 11559 II~ 38 II Inches 11965 II~ 390 l!Lbs 11176.9 IIBL US Measurements Metric Measun Return to Products J.>l!g~ http://proquote.airtek.com/qs-refrig.php?cPage=Prodpg0l.php&ID=5&cTable=SC 6/4/2008 3 DEVINE ENGINEERING, INC. 12316 Oak Knoll Rd., Suite C Poway, CA 92064 (858) 748-6168 ,70/] f'p:::: ---x.7 Wp7.., 7,1 Wp I 'L· S rp-::-_'1.1.x"J 'i O ~ ~7 It > r [ l I rsi 1 JOB ______________ ....!_\~0=s2.,S~·-==OO=- SHEETNO. ________ OF ___ ~--- CALCUL.ATED sy _ ____,_t---1...:....,Cg::::1,_ ____ DATE_..,..,'-IZ'----=-o-'& __ _ CHECKEDBY __ _,M'-"--'"Y'-{'-"-=0 ___ DATE _____ _ SCALE---------------- l Prl)fly-::: 3 '16 tt / / i / /' /41 tl,f ( " 1Aiv:r1 'f>ELlh-- D PRODUCT207 DEVINE ENGi NEERING, INC. 12316 Oak Knoll Rd., Suite C Poway, CA 92064 (858) 748-6168 7.<1 ft t:::. 7 1 re, ; u 6 6 /j JOB \~IS (2 .; A SHEET NO. CALCULATED BY MG CHECKED BY I?"v,.tD SCALE tA ,vr s,r fl. l. r CY-lNT I osS-,Uu OF DATE DATE <.o -<f:-<.l'.r:, : l i C.c..L Ci~JN l ! j ! l ·§ i ,; 6 v-P q_OQO ~ ffJm,1. x-= ·i 6 77!:r f 1 /. {l'C' ·l ~ i " " l fYlnt..<-..., 17?..o ltt-{,1 ·! "" -' i '-\ .i : ~ r; :i :i 0 ·, .. r ! 6 I l 0 C 1 JYk I I/ ( \ ({J) ~ 71 I I I /~ I {) 0 i l ?... 6S#'.. 1rr-ir..;c.: {},)'f(~) 5"/2 '¢J 1, •• / -i, '/2 ,, f.3 fl; {S/3-11 /"' f_ ~- r -( ( uis h n c-L 11.:i 6 (<: Unc<. --1 (,1 '( -..,.,; ,,,_,; ----- D PRODUCT 207 5 BLEVINS CUBED ARCHITECTS ,, Monday, June 09, 2008 Mr. Mike Peterson, Plans Examiner City of Carlsbad, California RE: 2282 Faraday, Isis Expansion and Alteration Project Dear Mr. Peterson: Attached you should find the following documents submitted for plan review: · 1. Three full size sets of Plans. 2. Two sets of Structural Calculations. 3. A letter from Isis indicating the project's impact on the existing Technical Report for the builqing. ,, Respectfully', Leaford L. Blevins Partner I Blevins CUBED Architects NORTH COUNTY DF'F'ICE 1 255 PHILLIPS STREET VISTA, CA. 9209_3• PH: 6 1 9 944 41 07 FX: 760 477 6032 ,, SAN DIEGO DF'F'ICE 7090 CAMINO PACHECO SAN DIEGO, CA. 921 1 1 PH: 61 9 944 41 1 5 Boulder Boston Philadelphia Cary Kalamazoo St. Louis Kansas City San Diego Thousand Oaks San Juan PARTNERS• July 31, 2008 Mr. Mike Peterson, City of Carlsbad Building Department, 1635 Faraday Avenue, Carlsbad, CA, 92008 Re: ISIS Pharmaceuticals -Tennant Improvement Project Costs for 'Tank Farm Platform' and 'Expansion and Automation'. Dear Mr. Peterson, CRB Partners have been appointed by ISIS Pharmaceuticals to manage the construction of a Tank Platform and various Tennant improvements at their facility on 2282 Faraday Avenue, Carlsbad, CA, 92008. We are informed by the Architect to the Project, Mr. Leaford Blevins of LB3 Architects that Building Permits are subject to construction cost appraisals. We wish to advise you of our cost evaluations for both the Tank Farm Platform and Tenant improvement components of the project as follows: For Civil, Structural, Architectural, HVAC, Mechanical and Electrical scopes of work pertaining to the supply and installation of the Tank Farm Platform and surrounds: $282,669 {Two Hundred and Eighty Two Thousand, Six Hundred and Sixty Nine Dollars) For Civil, Structural, Architectural, HVAC, Mechanical and Electrical scopes of work pertaining to the supply and installation of the Expansion and Automation scope: $975,731 (Nine Hundred and Seventy Five Thousand, Seven Hundred and Thirty One Dollars} We wish to advise you that these costs are based on the latest design drawings and associated subcontract bids. We hope this provides sufficient information but should you require any additional clarifications please do not hesitate to contact us. Sincerely, ~ CRB Partners Tom Mulkeen \ Senior Project Manager · Cell: 408 592 9257 Email: tom.mulkeen@crbusa.com 75 East Santa Clara Street, Suite 350, San Jose, CA 95113 • Tel 408.351.2014 • Fax 408.351.2059 • www.crbbuilders.com ISl-6 Pharmaceuticals 081378.00 Sub Contractor Bid Tabs Civil, Structural HYAC, Mech and BOD Ref# System Architectural Elec Subtotal Area Total Steel Platform Scope Steel Platform including House Vacuum & 1 Scrubber System $185,779 $96,890 $282 669 . Expansion and· Automation Scope 5 Process Tanks N/A $61,435 $61,435 6 Synthesizer Column East Suite (ISIS PO) N/A $1,171 $1,171 7 HPLC Column and pumping skid(ISIS PO) N/A $10,920 $10,920 Detritylation Skids (pH adjustment and 8 precipitation tank modifications) N/A $16,960 $16,960 9 Decant Operations N/A $45,668 $45,668 Cleavage Hood Number 2 improved valve 10 access 0,Nest Lab Rm 133) N/A $7,771 $7,771 New Cleavage Hood Number 5 (East Lab Rm 150) and Tanks plus improved valve 11 access N/A $3,306 $3,306 Toluene System; H2 Shed Piping and PLC 13 Modifications N/A $5,246 $5,246 14 PLC NIA $15,942 $15,942 15 Methanol and Water Systems N/A $33,669 $33,669 Waste Pot Level Controller (???) Fume 17 hood 7 , 10, 3, 2 NIA $14,488 $14,488 3 EmEx Fans in Mezz areas; HVAC Heat 18 Pumps N/A $106,232 $106,232 Dichloroacetic Acid [DCA] Dispensing -H2 20 Shed N/A $68,471 $68,471 21 Static Discharge (Elec Schematic) N/A $28,942 $28,942 23 Plant Steam N/A $166,933 $166,933 24 Bulk Flowmeters ( for Room 119 ref# 103) N/A $4,942 $4,942 25 East Freezer Dryer N/A $4,991 $4,991 34 Install Solvent Filters on all solutions N/A $2,500 $2,500 BMS System -Exhaust Fans to be BMS 98 automated N/A $31,985 $31,985 99 Replace Misc. Components N/A $14,664 $14,664 Bulk Gas Tanks N2 and Argon BMS hook- up, removal of redundant Argon rotameters 100 and valves N/A $14,887 $14,887 101 Compressed Air N/A $14,664 $14,664 103 Room 119 $38,647 $66,899 $105,546 G2 Insulation $28,399 $28,399 G3 Pneumatic Tubing $53,782 $53,782 G4 Painting $6,000 $6,000 G6 Certify Hoist lifting Points $8,000 $8,000 G7 Flooring replacements/ repairs $85,677 $85,677 G9 Passivation $12,540 $12,540 $975 731 7/31/2008 City of Carlsbad 1635 Faraday Av Carlsbad, CA 92008 12-02-2008 Plan Check Revision Permit No:PCR08130 Job Address: Permit Type: Parcel No: Valuation: Reference #: PC#: Project Title: Applicant: LEAF BLEVINS 619 496-0446 Building Inspection Request Line (760) 602-2725 2282 FARADAY AV CBAD PCR Status: 2120614600 $0.00 Lot#: 0 Applied: Construction Type: VN Ente~ed By: !SIS-INTERIOR DOOR CHANGES & Plan Approved: .Issued: Inspect Area: EXTENDING REVISIONS IN TO AREA LAB #166 (INCLUDES Owner: BMR-2282 FARADAY AVENUE LLC C/O PARADIGM TAX GROUP 3645 RUFFIN-RP #310 SAN DIEGO-CA 92123 Plan Check Revision Fee Additional Fees Total Fees: $360.00 Inspector: Total Payments To Date: $360.00 Balance Due: FINAL APPROVAL Date: Clearance: ISSUED 10/27/2008 RMA 11/12/2008 12/02/2008 $360.00 $0.00 $0.00 NOTICE: Please take NOTICE that approval of your project includes the "Imposition" of fees, dedications, reservations, or other exactions hereafter collectively referred to as "fees/exactions." You have 90 days from the date this permit was issued to protest imposition of these fees/exactions. If you protest them, you must follow. the protest procedures set forth in Government Code Section 66020(a), and file the protest and any other required information with the City Manager for processing in accordance with Carlsbad Municipal Code Section 3.32.030. Failure to timely follow that procedure will ba, any subsequent legal action to attack, review, set aside, void, or annul their imposition. You are hereby FURTHER NOTIFIED that your right to protest the specified fees/exactions DOES NOT APPLY to water and sewer connection fees and capacity changes, nor planning, zoning, grading or other similar application processing or service fees in connection with this project. NOR DOES IT APPLY to any fees/exactions of which vou have oreviouslv been aiven a NOTICE similar to this or as to which the statute of limitations has oreviouslv otherwise exoired. 4 lllcDn1,,.uD " •• Plan Check Revision ~0-PCAot IJ O Original Plan Check No. {;/Jof/o,.rf ProjectAddress IJ~'t:J~ ~,Pre-( Date _______ _ Contact /.¥AP J;,l.,,f?i I ~ Ph.t;,fv/1'lf4L{., ID-.:/-Fax G/1 lffb t)CfCf-,G Address (1-q"G pr-fkU{Jtb 7) I \/(v[ts-7 GA. 1-tof}-7 General Scope of Work p..fA!lv/13 hCO&,, e:F' f lJJ~ ~ ~6~ Original plans prepared by an architect or engineer,_revisions must be signed & stamped by that person. 1 Elements revised: . ~ns D Calculations D Soils D Energy D Other __________ _ 2 Describe revisions in detail 5 Does this revision, in any way, alter the exterior of the project? 6 Does this revision add ANY new floor area(s)? D Yes . 7 Does this revision ffect any fire related issues? D Yes 3 List page(s) where each revision is shown D Yes ~ ~ 4 List revised sheets that replace existin sheets ,4-JOS--I /.-7.. l'fl>J-7,/ ~~ f}-~O I A--b<>2-8 M-e Pl,JWC £S'Signature____,"--~---------------------1~!a.----FJ-{;.,<-\Uf--""'---.,,,._.. __ 1635 Faraday Avenue, Carlsbad, CA 92008 Phone: 760-602-2717 / 2718/ 2719 / 2721 Fax: 760-602-8558 . _, EsGil Corporation In <Partnersli.ip witli. government for (]3ui{tfing Safety DATE: 11/6/08 D APPLICANT JURISDICTION: City of Carlsbad ~ '0-i=>t~f:fREVIEW ER D FILE PLAN CHECK NO.: 081088 rev#l(PCR08130) PROJECT ADDRESS: 2282 Faraday SET:I PROJECT NAME: Isis Pharmaceuticals T. I. D D D The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's building codes. The plans transmitted herewith will substantially comply with the jurisdiction's building codes when minor deficiencies identified below are resolved and checked by building department staff. The plans,.transmitted herewith have significant deficiencies identified on the enclosed check list and shqH' be corrected and resubmitted for a complete recheck. / · list transmitted herewith is for your information. The plans are being held c::1t Esgil on until corrected plans are submitted for recheck. D The icarit's copy of the check list is enclosed for the jurisdiction to forward to the applicant j.;, D The applicant's copy of the check list has been sent to: ~ Esgil Corporation staff did not advise the applicant that the plan check has been completed. D Esgil Corporation staff did advise the ·applicant that the plan check has been completed. Person contacted: Telephone#: Date contacted: (by: ) Fax#: Mail Telephone Fax In Person D REMARKS: By: David Yao Enclosures: original approved plan EsGil Corporation D GA D MB D EJ D PC 10/30 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (858) 560-1468 + Fax (858) 560-1576 4JCity .. of Carlsbad 081088 rev#l(PCR08130) 11/6/08 [DO NOT PAY -THIS JS NOT AN INVOICE] VALUATION AND PLAN CHECK FEE JURISDICTION: City of Carlsbad rev#l(PCR08130) PLAN CHECK NO.: 081088 PREPARED BY: David Yao BUILDING ADDRESS: 2282 Faraday BUILDING OCCUPANCY: BUILDING AREA Valuation PORTION (Sq.Ft.) Multiplier T. I. revisions Air Conditioning Fire Sprinklers TOTAL VALUE Jurisdiction Code cb By Ordinance -----··--------··------· 3 Plan Check Fee by Ordinance ..,. ----------·------ Type of Review: D Complete Review D Other DATE: 11/6/08 TYPE OF CONSTRUCTION: Reg. VALUE Mod. D Structural Only D Repetitive Fee ~ Repeats 0 Hourly 3 j Hours * Esgil Plan Review Fee * Based on hourly rate Comments: ($) $360.ool $288.ooj Sheet 1 of 1 macvalue.doc Carlsbad Fire Department fJU§LDING oe:Fr .. COPY Plan Review Requirements Category: PCR , Date of Report: 11-30-2008 Reviewed by: ---¾.4-IJ-11-=-J~~.,, Name: LEAF BLEVINS Address: Permit#: PCR08130 Job Name: ISIS-INTERIOR DOOR CHANGES & Job Address: 2282 FARADAY AV CBAD -~--.0.,J. ade o etermine compliance with the applicable co es an ase review care ly all comments attached. Please resubmit the necessary plans and/or specifications, with changes "clouded", to this office for review and approval. Conditions: Cond: CON0003 l 76 [MET THIS PROJECT HAS BEEN REVIEWED AND APPROVED FOR THE PURPOSES OF ISSUANCE OF BUILDING PERMIT. THIS APPROVAL IS SUBJECT TO FIELD INSPECTION AND REQUIRED TEST, NOTATIONS HEREON, CONDITIONS IN . CORRESPONDENCE AND CONFORMANCE WITH ALL APPLICABLE REGULATIONS . . , THIS APPROVAL SHALL NOT BE HELD TO PERMIT OR APPROVE THE VIOLATION OF ANY LAW. Entry: 11/30/2008 By: GR Action: AP PCR08130 2282 FARADAY AV !SIS-INTERIOR DOOR CHANGES & EXTENDING REVISIONS IN TO AREA LAB #166 (()/ f2_7(oj' 1?J 1~ 1-fjG(c q' ~ Uj oi:/ C!Jef"'ioU A roved Building ~r~·~MA f I lD/sD(oc-Ci 1:'.) ~ fCJ'< Ar-eq__ \J l I / 1 ( 0 .f-•1 ~ -"f(A-1--)J: ~ -PC-R_ frru-=--A tL/ fut (q, ffe @Qt 'GlJ ~ (JJ /t1·R.c Affv-Q~L i,J-/--of'-/r.:T,-/f/-~~ l'>t W' ~ ' Planning Engineering Fire Health / F.O.G. HazMat/ Air Quality Comments Building Planning Engineering Fire Forms/Fees School CFD PFF PE&M Special lnsp. Fire Sewer --- Date Sent Rec"d Due.?\ By y IN \I'~ y N y N y N y N y ,_Nj y tj d1111rt--,Ji_