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Home My WebLink About2282 FARADAY AVE; ; CB970370; Permit, .. L [, I ;,1 13 ~} ~= / ~ I '3 ,,' l:i 7 ~ ~; : 2: 1 J l _-.., ,j:, ):t.1 }1 ;'[,:--~-•:;: .:• .~ e,~! t:p_~,'-l\~}[.'..,'T /~\/ ,.-:;·.CLtl t ~·-;~,£~1 :' : ~::t>1JS'!J:~J .. ~·\L TE:!/\1'.'!~1.'t J:·. ;:,~()'~/EI<E\t·T ~~1,:,.~i:cc:1 i.'•(1; .:1. ~-:·:t,~-~:.:i-1~·:; t,.:. <;.,, ;:: (_l !} :~'~111.~· 1~ !.·tt~t i 1 1;; T'~r~:i1~ ! ;\}£~9 3};:_:.J C t;_,$}9.~:~>, __ ;:G{!~ :;)!.::, \J:D;J, 1:ic( '--"-h•:..r.ic ;/ t.;J.. (>t...q;,: :),::·;::;cLi;)cJ.uLI, I:C1 .' r-:C-V! Pr) !-!L: i\J (~ , .• : ~} :-;J.\! ~320 STATE STREZT STE ~00 :?Pi\1 tiLE1.)(1 , 1~f..~ '..:!: ... fJ1 , '. -\ F :::· ,::.~ .:.: ~,~ :2 1.1 tt 14. · . .:1• _i_ ! \ '. -,,,, -·-----~ .. -. ·~ ·--__ ··"'--·-------------------------- 7 !:,.: 7 11 I) U,,, ,t ;_tl" ~: .:;. J1 t'~.: :·1 ,-1 ~~ .. , ;~ .:: 1-,rp§: Yr~;(~t~1 .:...::· :'"\ ½: f) ri • :1 c, . ', 1•.t', . ·' ' i:•,::, )0 :-: 0::'_'.:, , [l\J1$': :: :;,' 7. (/ '.I f<:··:' ~~12t::.c1 i:r;.,ci.·._111 ) '1 ..;,:+-.,->·, ·~:\~J-t n~i':: .\.. E;-:t f ,;a,.~ ~l::i~ 2t ---------------------. ' --. :--· ______ ·:_'/<('7 .. _:--~ . -. ..__ ::::~::-';: _,··· ,, \ ---------------- I:-L'.i ld1 t1<J ..:-·,::rm~.t · .::·:15.('tJ ~ -, ~ " 1->ldn. . c~ulLJ)I~\~\~; T':)T'-"4~ l? ~,, • Z.~t,?;\\t)(,t·:-1,' J:1.l t1.::-L-!=1r:,.r ... ~;vIF' f-:_,Ec1-,::~I('J.\L ~(.1~CP .. Y... f \' ,_ ~. / . \ \ '·,, lrJ. s :: ,~ -:~ ··... Fur n1'[)~.i .. c ts/ t-~ 1~ at:. _ _:.-·. ''G .\ .. '-'~~ ,: ~ -~ .11, l-. ~= (' 1\ I-, T\)1'}\L / APPROVAL DATE~4A1 CLEARANCE ____ _ CITY OF CARLSBAD 2075 Las Palmas Dr., Carlsbad, CA 92009 (619) 438-1161 -:'.'57.(:(1 ·_ (; • 'J f I 662, Cl(I t 2 (I , (J 0 1 (. OU 7. O:; ',,::.UlJ ·:. u. no I; 0, I,(: ,, J. J ':,. 11 I' '/ .... _._ PERMIT APPLICATION PLAN CHECK NO. City of Carlsbad Building Department 2075 Las Palmas Dr., Carlsbad, CA 92009 (619) 438-1161 1. PERMlT 1YPE From List 1 (see back) give code of Permit-Type: --~..:._T..,___._/ _____ _ For Residential Projects Only: From List 2 (see back) give Code of Structure-Type:.,..... __________________ _ Net Loss/Gain of Dwelling Units _________________ _ --;::·:-' 1 ''-!- ' 'I 2. PROJECT INFORMATION FOR OFFICE USE ONLY Address ~z:z.~~ ~AY 1'(1/(;" Bmidmg or Suite No. Nearest Cross Street S"PF!e i''ll? · '2 'O· 9Z// , ADD::ss 'ZZ-Cf?_ ~/ ~ ZIP CODE ·za;i.c> DAY TELEPHONE r J u~,, .... ,.un } LNAME-E)ast-nam.e first) ADDRESS CI1Y STATE ZIP CODE DAY TELEPHONE CI1Y BUSINESS LlC. # . i Workers' Compensation Declaration: I hereby afhrm that I have a certthcate of consent to self-msure issued by the Director of Industnal Relations, or a certificate of Workers' Compensation Insurance by an admitted insurer, or an exact copy or duplicate thereof certified by the Director of the insurer thereof filed with the Building Inspection Department (Section 3800, Lab. C). INSURANCE COMPANY POLlCY NO. EXPIRATION DATE Certthcate of Exemption: I certify iliat m ilie performance of the work for which this permit 1s· issued, I shall not employ any person m any manner so as to become subject to the Workers' Compensation Laws of California. ~ DATE 8. -0WNER-BUllJJER DECI.ARA'1IDN / Owner-Bmlder DeclaratJon: I hereby afhrm that I am exempt from the Contractor's Llcense Law for the foilowmg reason: 10"' I, as owner of the property or my employees with wages as their sole compensation, will do the work and the structure is not intended or offered for sale (Sec. 7044, Business and Professions Code: The Contractor's License Law does not apply to an owner of property who builds or improves thereon, and who does such work himself or through his own employees, provided that such improvements are not intended or offered for sale. If, however, the building or improvement is sold within one year of completion, the owner-builder will have the burden of proving that he did not build or improve for the purpose of sale.). D I, as owner of the property, am exclusively contracting with licensed contractors to construct the project (Sec. 7044, Business and Professions Code: The Contractor's License Law does not apply to an owner of property who builds or improves thereon, and contracts for such projects with contractor(s) licensed pursuant to the Contractor's License Law). D I am exempt under Section _______ Business and Professions Code for this reason: (Sec. 7031.5 Business and Professions Code: Any City or County which requires a permit to construct, alter, improve, demolish, or repair any structure, prior to its · uance, also requires the applicant for such permit to file a signed statement that he is licensed pursuant to the provisions of the Contr r's License Law (Chapter 9, commencing with Section 7000 of Division 3 of the Business and Professions Code) or that he is e mpt tll from, and the basis for the alleged exemption. Any violation of Section 7031.5 by any applicant for a permit subjects the a lie t t civil penalty of not more than five hundred dollars [$500]). SIGNATURE DATE bui i g occupant required to submit a business plan, acutely hazardous materials registr tion form or risk management and ons 25505, 25533 or 25534 of the Presley-Tanner Hazardous Substance Account Act? 0 YES D NO . Is the applicant or future building~up t required to obtain a permit from the air pollution control district or air quality management district? 0 YES 0 Is the facility to be constructed wi ~l, O feet of the outer boundary of a school site? 0 YES NO IF ANY OF nm ANSWERS ARE YFS, AL CERTIFICATE OF ocx:uPANCY MAY NOT BE~ AFfER JULY I, 1989 UNLF.SS nm APPLlCANT HAS MET OR IS MEETING nm REQUIREMENTS OF nm OFFICE OF EMERGENCY SERVICFS AND nm AIR POILUTION OONTilOL DISTRICT. 9. CoNS'l'R0CnON LRNDING AGENCY I hereby affirm that there ts a construction lendmg agency for the performance of the work for which this permit 1s issued (Sec 3097(1) CiVl[ code). ' LENDER'S NAME LENDER'S ADDRESS io. APPllCAN I CE.R1MCA'IION I certtly that I have read the apphcatton and state that the above mformatton 1s correct. I agree to comply with all Ctty ordmances and Mate laws relating to building construction. I hereby authorize representatives of the City of Carlsbad to enter upon the above mentioned property for inspection purposes. I ALSo AGREE 10 SAVE JNDEMNIFY AND KEEP HARMLESS nm CI1Y OF CARISBAD AGAINST AIL UABIUTIES, JUDGMENTS, COSIS AND EXPENSES WHICH MAY IN ANY WAY ACCRUE AGAINST SAID CI1Y IN OONSEQUENCE OF nm GRANTING OF TIIlS PERMIT. Expiration. Every permit issued by th , building or work authorized by s~h p such permit is suspended or aba on d APPLlCANTS SIGNATURE ' " eep and demolition or construction of structures over 3 stories in height. 5 days from the date of such permit or if the building or work authorized by mmenced for a period of 180 days (Section 303(d) Uniform Building e). DATE:~~~""1 . Applicant PINK: Finance ~ CITY OF CARLSBAD J INSPECTION REQUEST PERMIT# CB970370 FOR 06/04/97 DESCRIPTION: ITI 1800 SF, PARTITIONS,ELEC DUCTWORK,PLUMBING, 1 1/2 STORIES TYPE: ITI AV STE: INSPECTOR AREA TP PLANCK# CB970370 OCC GRP CONSTR. TYPE NEW LOT: JOB ADDRESS: 2282 FARADAY APPLICANT: POHLING, JOHN CONTRACTOR: PHONE: 619 230-9211 PHONE: OWNER: PHONE: REMARKS: BJN/RON/990-6066 SPECIAL INSTRUCT: INSPECTOR TOTAL TIME: --RELATED PERMITS--PERMIT# SE930055 FA930018 AS930058 TYPE swow FALARM ASC STATUS ISSUED ISSUED ISSUED --fr---------- CD 19 29 39 49 LVL DESCRIPTION ACT COMMENTS ST Final Structural PL Final Plumbing EL Final Electrical ME Final Mechanical Af? ------------1=--- ------------------------------------------------------ ***** INSPECTION HISTORY***** DATE 051397 051397 051397 043097 043097 042897 042897 042897 041597 DESCRIPTION Rough/Ducts/Dampers Frame/Steel/Bolting/Welding Rough Electric Interior Lath/Drywall Rough/Ducts/Dampers Frame/Steel/Bolting/Welding Rough/Topout Rough Electric Underground/Under Floor ACT INSP AP TP AP TP AP TP AP TP PI TP AP PK AP PK AP PK AP TP COMMENTS DUCTS T-BAR GRID CEIL LITES WALLS WALLS WALLS EsGil Corporation Professional Pfa.n 'R._eview 'Engineers DATE: 3/27 /97 JURISDICTION: Carlsbad PLAN CHECK NO.: 97-370 PROJECT ADDRESS: 2282 Faraday Ave. PROJECT NAME: ISIS Pharmaceuticals TI SET:I · D~ANT ~ D PLAN REVIEWER D FILE • The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's building codes. D The plans transmitted herewith will substantially comply with the jurisdiction's ********** codes when minor deficiencies identified below are resolved and checked by building department staff. D The plans transmitted herewith have significant deficiencies identified on the enclosed check list and should be corrected and resubmitted for a complete recheck. D The check list transmitted herewith is for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. D The applicant's copy of the check list is enclosed for the jurisdiction to forward to the applicant contact person. D The applicant's copy of the check list has been sent to: B Esgil Corporation staff did not advise the applicant that the plan check has been completed. D Esgil Corporation staff did advise the applicant that the plan check has been completed. Person contacted: Date contacted: (by: Mail Telephone Fax In Person D REMARKS: By: Chuck Mendenhall Esgil Corporation D GA D CM O EJ O PC Telephone#: Fax#: Enclosures: 3/20/97 -trnsmtl.dot 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (619) 560-1468 + Fa-x (619) 560-1576 EsGil Corporation Professiona[ Pfan 'R...,eview 'Engineers DATE: 3/5/97 JURISDICTION: Carlsbad PLAN CHECK NO.: 97-370 PROJECT ADDRESS: 2282 Faraday Ave. PROJECT NAME: ISIS Pharmaceuticals TI SET:I D APPLICANT _/Cl JURIS . .:::> D PLAN REVIEWER D FILE D The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's *********** codes. D The plans transmitted herewith have significant deficiencies identified on the enclosed check list- and should be corrected and resubmitted for a complete recheck. • The remarks below are transmitted herewith for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. Submit three sets of revised plans/ data to the city or submit 2 sets to the city and 1 set directly to EsGil Corp. for recheck. D The applicant's copy of the check list is enclosed for the jurisdiction to forward to the applicant contact person. • The applicant's copy of the check list has been sent to: John Pohling 1520 State St, #100, San Diego, CA 92101 • Esgil Corporation staff did not advise the applicant that the plan check has been completed. D Esgil Corporation staff did advise the applicant (except by mail) that the plan check has been completed. Person contacted: Telephone #: • REMARKS: 1. Provide a written description of the uses of the remodeled areas. Describe the types of chemicals used, the quantities and the purpose for the expanded use. 2. Include with the Tl an update letter for the existing hazardous materials report for this facility. The update letter must address the expanded use of the improved areas and how these will affect the original control areas. 3. Specify the type chemicals used in the existing exhaust systems that will be used for the new hoods. Are the chemicals used in the existing exhaust systems compatible with the intended use and chemicals for the proposed hoods? By: Chuck Mendenhall Esgil Corporation 0 GA O CM O EJ O PC 2/27/97 Enclosures: trnsmtl.dot 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (619) 560-1468 + Fax (619) 560-1576 VALUATION AND PLAN CHECK FEE JURISDICTION: Carlsbad PREPARED BY: CM PLAN CHECK NO.: 97-370 DATE: 3/5/97 BUILDING ADDRESS: 2282 Faraday'Ave. BUILDING OCCUPANCY: B TYPE OF CONSTRUCTION: III N BUILDING PORTION BUILDING AREA VALUATION VALUE (ft. 2) MULTIPLIER ($) Tl 588 City Estimate 46,800 Air Conditioning Fire Sprinklers TOTAL VALUE 46,800 • 1991 USC Building Permit Fee D Bldg. Permit Fee by ordinance: $ 395.00 • 1991 USC Plan Check Fee D Plan Check Fee by ordinance: $ 256.75 Type of Review: • Complete Review D Structural Only D Hourly D Repetitive Fee Applicable D Other: Esgil Plan Review Fee: $ 205.40 Comments: Sheet 1 of 1 macvalue.doc 5196 PLANNING/ENGINEERING APPROVALS PERMIT NUMBER CB q7-0)70 DATE 3-Cf-'ft RESIDENTIAL RESIDENTIAL ADDITION MINOR ( < $10,000.00) TENANT IMPROVEMENT PLAZA CAMINO REAL VILLAGE FAIRE COMPLETE OFFICE BUILDING OTHER_~1~-k-~_. _______ AJ~C2"--~f?A~.Mr':~~~G-~_~_vC::r _____ _ PLANNER v~ DATE$...-t-/--9'7 --,,;,:.----------- C:\ WP51 \FILES\BLDG.FRM Rev 11 /15/90 City -of Carlsbad 97086 Fire Department • Bureau of Prevention Plan Review: Requirements Category: Building Plan Check Date of Report: Friday, April 4, 1997 Reviewed by: C. OaJ.-<.~L Contact Name John Pohling Address 1520 State St ------------------ City, State San Diego CA 92101 Bldg. Dept. No. CB97-370 Planning No. Job Name ISIS Pharmaceuticals Job Address _2_2_82_F_a_ra_d~ay.__ ____________ _ Ste. or Bldg. No. ____ _ ~ Approved -The item you have submitted for review has been approved. The approval is based on plans; information and/or specifications provided in your submittal; therefore any changes to these items after this date, including field modifica- tions, must be reviewed by this office to insure continued conformance with applicable codes. Please review carefully all comments attached, as failure to comply with instructions in this report can result in suspension of permit to construct or install improvements. D Disapproved -Please see the attached report of deficiencies. Please make corrections to plans or specifications necessary to indicate compliance with applicable codes and standards. Submit corrected plans and/or specifications to this office for review. For Fire Department Use Only Review 1st'-----2nd. __ _ 3rd. __ _ Other Agency ID CFD Job# __ 97--'0'-8--'-6 __ File# ___ _ 2560 Orion Way • Carlsbad, California 92008 • (619) 931-2121 03/ 18/97 10: 32 ·" ~ 5'2309202 CARRIER DESIGN l 20 Stele Stroet s it O 1 0 0 S n Diego, CA 9 ?. l O 1 6 9-230-9211 F X-230-9202 FAX TRANSMITTAL Date: {<b 41 To: Attention: Fax Nurnber: !:?f?O· lf>1k Project: Project No.: Description: Rernarl<s: Number of pages included in this transmis8ion including cover sheet: __ '{ __ _ Please hand deliver to the individual referenced above and telephone us ff you have any problems with the ttL"" m~-sion. Prepared By · \ -_ ...... Copies to: [{lloo1 03/18/97 10:32 '6"2309202 CARRIER DESIGN f4I 002 1 ,· • .' .:: •• · ·.· fi · EsGil Corporat1orr'1 Professional Platt. !l{e.Vie'lJ) 'EtffJi'llUTS :' --... ' .. . : .. _; :. ·. -~· .... :: ... :,._.: ~ .. ·' .. :_: ... ·~·:_ =._.~: .... ~·: .. :.·.r~.;C }:':-'.-:-'.. ' ATE: 3/5/97 . .. . . "· ·:.· .:-.. ·:;;·.-:.:··.:··::'.'.-~·:·::.-:: ... · · .. '"',-: : .. :···.· .·_··.:,;-:;;;'"-~ APPLICANT . . ,, . . . . . . D· JURIS.-. ,' ' . . . . .. . . URISDICTION: Ca~lsb~d ,. LAN CHECK NO.: 97-370 ROJECT ADDRESS: 2282 Faraday Ave. ROJECT NAME: ISIS Pharmaceuticals TI ,, . . ci' PLAN' REVIEWER · .. D FILE SET:I The· F)lans transmitted herewith have been corrected where necessary-and substantially comply with the jurisdiction's ****-tt-lrlrlt codes. The plans transmitted herewith have significant deficiencies identified on the enclosed check list and should be corrected and resubmitted for a complete recheck. The remarks below are transmitted herewith for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. Submit three sets of revised plans/ data to the city or submit 2 sets to the city and 1 set directly to Es~il Corp. for recheck. • • ,,ff ·:,.-. • The applicant's copy of the check list is enclosed for the jurisdiction to forward to the applicant contact person. · :._·-'·-.-· .. :. · ~ · · .. The applicant's copy of the check li~t has been sent to: John Pohling 1520 State St, #100, San Diego, CA 92101 • Esgil Corporation staff did not advise the applicant that the plan check, has been completed. [3-·· Esgtt earpuratton staff·did~advfse the applicant (except by mart) that-the plan check has-been completed. Person contacted: Telephone#: • REMARKS: 1. Provide a written description of the uses of the remodeled areas. Describe the types of chemicals used I the quantities and the purpose for the expanded usenA\\\nc1ude with the Tl an update letter for the existing hazardous materials report for this facmt?fh~ update letter must address the expanded use of the improved areas and how these will affect the original control areas. 3. Specify the type chemicals used in the existing exhaust systems that will be used for the new hoods. Are the chemicals used in the existing exhaust systems ~compatible with the intended use and ch~mlcals for the proposed hoods? By: Chuck Mendenhall Esgil Corporation 0GA 0CM OEJ 0PC 2/27/97 Enclosures: trnsmtl.dot 9320 Chesapeake Drive. Suite 208 + San Diego, California 9212:3 + (619) S60-l468 + Fax (619) 560~1576 !' I.( ~: !c:'. ~ r r > ' t I~ . 03/18/97 10:33 '5'2309202 CARRIER DESIGN ISIS PHARMACEUTICALS: 2282 Faraday Avenue, Carlsbad CA 92009 HAZARDOUS MATERIALS & OCCUPANCY CLASSIFICATION ANALYSIS 1.0 OVERVIEW 1.1 Scope and Summary This Technical Report was prepared by Eriksen-Rattan Associates Inc. at the request of Isis Pharmaceuticals for their facility located at 2282 Paraday Avenue in the City of Carlsbad, California. Tbe .., report addresses minor changes to hazardous materials operations in existing "Control Area 3".; "Control Area 3" was originally permitted as a Group B, Division 2 Occupancy area of the building and the changes proposed for ''.Coutnif Area 3" WIii not impact its current occupancy classificetion. / Applicable Code requirements and conditions for the types and amounts of hazardou_s materials involved in "Control Area 3" are the same today as they were when "Control Area 3" was originally permitted by the City of Carlsbad. See the previously submitted 3-15-~3 Technical Report prepared by Eriksen·Rattan Associates Inc. for existing "Control Area 3" .. conditions and reciuirements. The proposed modifications to "Control Area 3" addressed herein were evaluated based on the 1994/1995 editions of the Uniform/Ca/ifom,a Codes. The types and amounts of hazardous materials addressed herein are based on information provided to Eriksen-Rattan Associates Inc. by Isis Pharmaceuticals. Discrepancies between this report and actual field conditions are the sole responsibility of: Isis Pharmaceuticals. Review of plans, equipment and processes associated with Isis Pharmaceuticals' proposed changes for determination of compliance with applieabl~ Code requirements and provisions is outside the scope of this report and is not the responsibility of the report preparer. Technical f<epott-Con~rQi Area 3: Section A -Findings & Requirements E$$en-Rattan Associate$ lno. -·--·-···· 3/13/97 • Page 1 of 5 '41003 I I I 03/18/97 10:33 ft2309202 CARRIER DESIGN ' ' . ?f ?~~\\;. ~::::;?.;(~::~~-~-?-:,-- (SIS PHARMACEU~I_CAL~_:_~282 Far~~lay Ave~u~? Carl~bad CA 92009 HAZARDOUS MATERIALS & OCCUPANCY CLASSIFICATION ANALYSIS 1.2 Information Questions regarding Isis Pharmaceutical's hi:l2ardous materials operations and' proposed changes should be directed ta: ISIS PHARMACEUTICALS Karl Kasai 2292 Faraday Avenue Carlsbad, California 92009 Telephone 619.603.2480 FAX 619.929.0528 Questions regarding the project involving the proposed changes should be directed to: THE HARRISON COMPANY Steve Harrison 4401 Manchester Avenue -Suite 205 Encinitas, California 92024-4938 Telephone 619.753.28:24 FAX 619.753.3301 Questions regarding this report should be directed to: ER1KSEN-RA1TAN ASSOCIATES INC. Mary Eriksen-R~ttan . 8989 R.io San Diego Drive -Suite 200 San Diego, California 92108-1649 Telephone {619)299-6444 FAA {619)299-1229 Ti!:chnic.il Report -Cont~ol Area 3: Section A • Findings & Requirements Eriksen-Rattan As"c.'.'lciates Inc. ·-·· · · · 3/13/97 -Page 2 of 5 141004 l l I I I I I I I I I 03/18/97 10:34 '5'2309202 CARRIER DESIGN .; ISIS PHARMACEUTICALS: 2282 Faraday Avenue, Carlsbad CA 92009 HA?A,RDOUS MATERIALS & OCCUPANCY CLASSIFICATION ANALYSIS 2.0 FINDINGS 2.1 Existing Conditions Original Permit Condi~ons: • Isis Pharmaceuticals existing laboratory rese_erch and development operations are located at 2282 Faraday Avenue in the City of Carlsbad, California. • The existing building addressed.in this report is a 2-story, fully sprinklered building, originally permitted by the City of Carlsbad as a Group. B, Division 2 Occupancy building with four [4] / hazardous materials "Control Areas"J • An existing 1-story, fully sprinklered, Group H, Division 317 Occupancy solvent and radioactive materials storage area is attached on the back side of the building, adjacent to existing "Control Area 211• • See the previously submitted 3~·15-93 Technical Report prepared by Eriksen-Rattan Associates Inc. for the original site conditions. · 1995-1996 Pennit Modifications: • Modifications were made to the existing building in 1995-1996 involVing "Control Area 111 and the addition of a Groi.tp H, Division '217 Oc:ai.Jpancy detached1 prefabricated chemical storage building. · • See the previously submitted 8-13-95 Technical Report prepared by Eriksen-Rattan Associates-Inc. for the 1995-1996 modifications. 1echnlca1 Report • Control Area 3: seimon A -rindlngs & Requirements En'ksen-Rattan Associates Inc, 3113197 -Page 3 of 5 141005 I I I ' I· 1· I· I .... . . 03/18/97 10:34 fi"2309202 CARRIER DESIGN 4:.. t > ' ISIS PHARMACEUTICALS: 2282'Faraday Avenue. Carlsbad CA 92009 HAZARDOUS MATERIALS & OCCUPANCY CLASSIFICATION ANALYSIS 2.2 Modifications to Existing Conditions Minor changes to hazardous materials operations Will be made to existing ucontrol Area 3". , ihe hazar~ous materials related changes will · involve the following conditions. For construction related modifications, see the plans submitted separately by others. • H~ardous Materials lnventoey: • Seven {7] additional hazardous materials will be added to ·control Area 3" for operations in the existing "Scale-Up L~b" [room 113]. The materials and quantities that will be added to "Control Area 3n are as· follows: • Acetonitrile -4.2267 ga)lons [increase in quantity for existing material] • Dichloromethane -4.2267 gallons [increase in quantity for existing material] • Diethylamine-0.2641 gallon [new material] • Ethanol~ 1.0566 gallons ~ncrease in quantity for existing material] • Hexane -1.0566 gallons [new materiaij • Methanol -1.0566 gallons [increase in quantity for existing material] • Sodium Hydroxide -0.6604 gallon [increase in quantity for existing material] • The occupancy classification of"Control Area 3" will not be impacted by the addition of the materials indicated above. · See Section B -Hazardous Materials Inventory Analysis - Control Area 3. • The operations involVing the new hazardous materials are essentially the same as eXisting operations. See the previously submitted 3-15~93 Technical Report by Eriksen- Rattan Associates inc. for details for existing operations. • Equipment: + Three (3] new exhausted erclosures will be added in the following locations in existing "Control Area 3n: • Scale-Up Lab [room 113]; New 8' walk-in hood/exhausted enclosure New 4' fume hood/exhausted enclosure • Fill Room [room 111a]:'-New 6' laminar flow hood/exhausted enclosure • Both existing and new haz~rdous materials will be used in the new exhausted enclosures in the Scale-Up Lab [room ·113]. • Existing hazardous materials will be usd in the new exhausted enclosure in the Fill Room [room 111a] . • The occupancy classification of "Control Area 3" will not be impacted by the addition of the new exhausted enclosures indicated above. See Section B -Hazardous Materials Inventory Analysis -Control Area 3. + Both the existing and new ~quipment are suitable for the types and amounts of hazardous materials that will be used _in "Control Area 3n. • The operations involving tlie new exhausted enclosures are essentially the same as existing operations. See the previously submitted 3-15-93 Technical Report by Eriksen- Rattan Associates inc. for details for existing operations. Technical Report -Control Area 3; Sectiori A -Findings & Requirements En"ksen•Rattan A$$Ociates Inc. 3/13/97-Page 4 of5 141006 t. f l J I I I I I I I I I I I I I 0.3/18/97 10:.35 *5'2.309202 CARRIER DESIGN f\ • .> ' ,., " ISIS PHARMACEUTICALS: 2282 Faraday Avenue, Carlsbad CA 92009 HAZARDOUS MATERIALS & OCCUPA~CY CLASSIFICATION ANALYSIS 3.0 REQUIREMENTS Applicable Code requirements for the additional hazardous materials and new exhausted enclosures that will be located in existing ''Control Area 3" are the same _as the requirements previously identified in the 3~ 15r93 Technical Report prepared by Eriksen-Rattan Associates Inc. for the existing building.· Although the 3~15-93 report was prepared based on requirements and conditions appearing in the 1991 Codes, the requirements and conditions appearing in the 1994/1995 Codes have not changed for either the types and amounts of hazardous materials involved or the conditions in which the hazardous materials will be stored, used or handled. For details, see the previously submitted 3-15-93 Technical Report referenced above. Technical Report• Control Area :3'. Saetion A-Findings & Requirements Eriksen-Rattan Assoc::iates Inc::. 3/13/97 -Page 5 of 5 141007 03/24/97 18:20 '5"2309202 ·CARRIER DESIGN ARRI ER ES!GN · ROUP FAX TRANSMITTAl Date: To: Attention: Fax Number: Project: Project No.: Description: Remarks: Number of pages included in this transmission including cover sheet: __ "2 __ ·-_-_ Please hand deliver to the ind u I referenced above and telephone us if you have any problems with the tran i ion. Prepared By Copies~: .~ci; ~flt; 1.52 Srare Street ( Su te 100 San Diego, CA 9 ' l O l 619 230-9211 rAX 230-9202 141001 ' .. ,. _,,. 2600 CARRIER DESIGN ISIS PIU.RM. DEV. ISIS PHARMACEUTICALS~ INC .. 2292 Faraday A venue Car.lsbad, California 9.2008 Facsimile Information Sheet Date: sP'l/t7 From: . Karl Kasai Phone (619) 603-2480 FAX (760) 603-2600 Number of page~ transm.im~d is ,2__ ,including this cover sheet. Fk::~t~e deliv<=r the: following information to: Name: jt>J j/N4 Company: (;,p,/,:r# ~// FAX No.: ;?&:; ..... 7-;;vZ,. Phone: COMMEN"fS: Sea.le -Up Lab (room 113) In addition to existing operations in this lab, orga.nic che.mlstry will be performed. Large scale reactions; using wer chemi:m-y techniques will be performed in Ihe new and existing forrie hoods. Solv1t-nt.i;; are typical of those u~ed in organic chemistry. Processing Roorn (room 111) [si-; drugs will be formulated here in this lab. Drugs are formulated using bulk drug ~uhstancc, salts and water_ Fill Roorn (t"oo.rn l l la) Fci-mulaced drugs will be dispensed i.nto vials within the new laminar now hood. Staging Room (room 110) Vials rhat are filled from Fill Room are to be staged in this lab. Lo.bc;Hng Room (room 11 Oa) Vials an: to be labeled in ibis lab. 141002 @Joo: