Loading...
The URL can be used to link to this page
Your browser does not support the video tag.
Home
My WebLink
About
2714 LOKER AVE W; 100; CB962114; Permit
City of Carlsbad INDUSTRIAL TENANT IMPROV Permit No:CB962114 2714 LOKER AV WEST 100 ITI 2090810200 2109 SF-NEW WALLS,LIGHTS,CEILG HVAC,PLUM-OFFICE/LAB-CYPRO Job Address: Permit Type: Parcel No: Reference No: PC #: Project Title: FINAL 11/04/1996 01/21/1997 01/21/1997 Status: Applied: Approved: Issued: Inspect Area: Lot #: Applicant: NEWPORT NATIONAL 5050 AVENIDA ENCINAS STE 30 CARLSBAD CA Owner: PACIFIC INDUST PROP HOLDINGS I 00130104993 Strong Motion Fee $12.00 00136104221 Building Permit $437.00 00136104222 * PLUMBING TOTAL $55.00 00136104223 * ELECTRICAL TOTAL $60.00 00136104224 * MECHANICAL TOTAL $62.00 00136104885 Plan Check $284.00 00130104993 Strong Motion Fee $12.00 00136104221 Building Permit $437.00 00136104222 * PLUMBING TOTAL $55.00 00136104223 * ELECTRICAL TOTAL $60.00 00136104224 * MECHANICAL TOTAL $62.00 00136104885 Plan Check $284.00 $910.00 $0.00 $910.00 $0.00Fees:Additional Fees:Total Fees:Balance: J:j:~ Lf:11 t i1l(1 : C't:9t1~l _:_ :· . . tJ j_ ., :.: l .. ·~; 7 l i) : z 1:1 J.:rr(.;jECt 1.1]i:i: "fa_'?,:,1_i,:,1 :1;~ [lr2v<2l(,j:Jf:1(:•nt I_l;u: lJot, A,J 1-1re:J:::: 2714 Ll)l-:E}t AV~ r./E':5,~)--::iuite: :iUO P,.:·:cmi t Type: INDUSTRIAL 'I'Ei'JANX IMPROVENE1·!T ::'.J1 . .S ().1,'~~L'9-i (.GQ !. '·i (r~ P . .::.ccel i:{c,: 209-01:H-112-uu ,1.:=t.1. ~wt 1 c,n: Occupancy Group: Reference#: [1,:-sci:' ipt i(,n: 2.1 (1 ':' Sf-i':EJ; WALL:7,, LIGHTS, CEILG : HVAC, PLUl··~-OFFlCE lLAE·-CYP.RO NE~PORT NA~IONAL 5ll':i0 A\TENIDA EI-JCIHAS STE JOO CARLSBAD CA 92uns _;:i.,JJu'.!-:tment s: T,:,t c, 1 F e,2'::-:: f'1?1::' dezc:ciption , ELECTRICAL TOTAL Enter 'Y' for Mechanic,.:tl J'~,,:'-' In~tall Furn/Ducts/Heat Pumps, E :tCh E>:haust F'.;tn 1. I·ECEAI<JICP.L :,.-oTA: ·' .•• .:1----· Cunstruction Type: Vl st.:£tu~: rsst;£·~> Applied: !1/04;96 Apr/ISSUE: Oi/21197 Ent':·.t.-,~ .. J E:/: fJ·lA ::: . cu 6.5U .00 s.6.::.uu '.!. •: 7 . 1) () Ext fe,-=- ll .:i 7 • flu 1~. Oil 72,:,.oo 2 0. () 0 Y 2 '.::. 00 7. 1)1) ::is.no ill.PU Y so.oo t:tU,OtJ 15.0U Y ::.7.Uf.l 1 '3. ':, u 6 ;:: . (t;J APP-RO VAL INSP .. .,... _ _. DATE=~diJ1 ...!.p CLF~ 0 .~~NCE _____ _ '-~·· CITY OF CARLSBAD 2075 Las Palmas Dr., Carlsbad, CA 92009 (619) 438-1161 c_t # 3/.tJD/d.~ PERMIT APPUCATION City of Carlsbad Building Department 2075 Las Palmas Dr., Carlsbad, CA 92009 (619) 438-1161 1. PERMIT 1YPE From List 1 (see back)'-give code of Permit-Type: ___________ _ For Residential Projects Only: From List 2 (see back) give Code of Structure-Type: _____________________ _ Net Loss/Gain of Dwelling Units _________________ _ 2. PRQJECT INFORMATION rry/ '-/-Lo~ U-Ave_ Nearest Cross Street CHECK BEWW IF SUBMI'11ED: D 2 Energy Gales D 2 Structural Gales D 2 Soils Report D 1 Addressed Envelope PLAN CHECK NO. q t 2t ( FSf. VAL 1 d'-' ,, {? D 0 PIAN CK DEPOSIT _____ ----if=IP VALID.BY. __ -:--:r--1--:--;---++--=-- DATE:...... ___ +-'f' ...... -=t-+--f:-f-:!"'T--- mt o. FOR OFFICE USE ONLY P ase o. ·,· •,:. ASSESSOR'S PARCEL EXISTIN~SE PROPOSED J?SE ,s._. -· DE~RIPTIO~rC?E..WORK ~if·~ Ae..w u-'C:Z...l ~ $. / 1'4' h ~ l'\q ,ce,i ( t' trv:/ {-h)~C, C:.::: -b ( J Y"hb \~q ~ro~·t,:·-tc.e./ . -1::,.Pcc.C~ I J J J. I T J SQ. FT. • '£> I # OF STORIES ._3;, # OF BEDROOMS -# OF BATIIROOMS - I NAME (last.name first) ADDRESS CITY STATE ZIP CODE DAY TELEPHONE 4. APPllCANT O CON'l'RAC'IDR .JtAcEN'l' FOR CON'l'RAC'IDR O OWNER O AGEN I FOR OWNER NAME (last name first) +t-a...rri ,s 17~~?£-'::f., D . 'e;ioK. Cj 30 CITY :row -STATE ' kZIP CODE qzo,L{-DAY TELEPHONE Lf'E:,(a -5~ I NAME (last name first) i\Je.J.vror-+ CITY ADDRESS ZIP CODE DAY TELEPHONE STATE IJC. # IJCENSE CLASS CITY BUSINESS IJC. # SIGNATURE DATE 8. oWNER-BOllJJER DECI.ARA'l10N Owner-Bmlder Declarauon: I hereby afhrm that I am exempt from the ContractoPs Llcense Law for the followmg reason: D I, as owner of the property or my employees with wages as their sole compensation, will do the work and the structure is not intended or offered for sale (Sec. 7044, Business and Professions Code: The Contractor's License Law does not apply to an owner of property who builds or improves thereon, and who does such work himself or through his own employees, provided that such improvements are not intended or offered for sale. If, however, the building or improvement is sold within one year of completion, the owner-builder will have the burden of proving that he did not build or improve for the purpose of sale.). D I, as owner of the property, am exclusively contracting with licensed contractors to construct the project (Sec. 7044, Business and Professions Code: The Contractor's License Law does not apply to an owner of property who builds or improves thereon, and contracts for such projects with contractor(s) licensed pursuant to the Contractor's Llcense Law). D I am exempt under Section _______ Business and Professions Code for this reason: (Sec. 7031.5 Business and Professions Code: Any City or County which requires a permit to construct, alter, improve, demolish, or repair any structure, prior to its issuance, also requires the applicant for such permit to file a signed statement that he is licensed pursuant to the provisions of the Contractor's License Law (Chapter 9, commencing with Section 7000 of Division 3 of the Business and Professions Code) or that he is exempt therefrom, and the basis for the alleged exemption. Any violation of Section 7031.5 by any applicant for a permit subjects the applicant to a civil penalty of not more than five hundred dollars ($500]). SIGNATURE DATE COMP1ETE THIS SECTION FOR NON-RESIDENi1AL BUILDING PERMITS ONLY: Is the applicant or future building occupant required to submit a business plan, acutely hazardous materials registration form or risk management and prevention program under Sections 25505, 25533 or 25534 of the Presley-Tanner Hazardous Substance Account Act? Is the applicant ffu~;e building occ~a~~ required to obtain a permit from the air pollution control district or air quality management district? DYES JaNO Is the facility to be constructed within 1,000 feet of the outer boundary of a school site? DYES }.q NO IF ANY OF TIIE ANSWERS ARE YES, A FINAL CERTIFICATE OF OCCUPANCY MAY NOT BE ISSUED AFfER JULY I, 1989 UNLF.SS TIIE APPIJCANT HAS MET OR IS MEETING TIIE REQUIREMENTS OF TIIE OFFICE OF EMERGENCY SERVICES AND TIIE AIR POIJ.UTION CDN1ROL DISfRICT. 9. OONS'l'ROCIIDN LENDING XGRNCY I hereby afhrm that there 1s a construcuon lendmg agency for the performance of the work tor which· this permit 1s issued (Sec 3097(1) CIVll Code). LENDER'S NAME LENDER'S ADDRESS to. APP11CAN I Cfill1'll1CA'I10N I cerufy that I have read the apphcauon and state that the above mformauon 1s correct. I agree to comply with all City ordmances and State laws relating to building construction. I hereby authorize representatives of the City of Garlsbad to enter upon the above mentioned property for inspection purposes. I ALSO AGREE 'IO SAVE INDEMNIFY AND KEEP HARMLESS TIIE CITY OF CARISBAD AGAINSf All. IJABIIITIES, JUDGMENTS, CDSTS AND EXPENSF.S WHICH MAY IN ANY WAY ACCRUE AGAINSf SAID CITY IN CDNSEQUENCE OF TIIE GRANTING OF 1HIS PERMIT. OSHA: An OSHA permit is required for excavations over 5'0" deep and demolition or construction of structures over 3 stories in height. CITY OF CARLSBAD INSPECTION REQUEST PERMIT# CB962114 FOR 03/07/97 DESCRIPTION: 2109 SF-NEW WALLS,LIGHTS,CEILG HVAC,PLUM-OFFICE/LAB-CYPRO TYPE: ITI JOB ADDRESS: 2714 LOKER AV WEST APPLICANT: NEWPORT NATIONAL CONTRACTOR: OWNER: REMARKS: MW/JIM/PG 960-9345 SPECIAL INSTRUCT: TOTAL TIME: --RELATED PERMIT$--PERMIT# CO960036 AS970005 TYPE COFO ASTI STATUS ISSUED ISSUED INSPECTOR AREA TP PLANCK# CB962114 OCC GRP CONSTR. TYPE Vl STE: 100 LOT: CD LVL DESCRIPTION ACT COMMENTS 19 ST Final Structural d!... -------------29 PL Final Plumbing 39 EL Final Electrical 49 ME Final Mechanical t=-. ----- --------'------------------------------- --------'------------- ***** INSPECTION HISTORY***** DATE 030497 030497 030497 030497 022197 022197 021897 021897 021397 020697 012897 012897 012797 DESCRIPTION Frame/Steel/Bolting/Welding Rough Electric Rough/Top out Rough/Ducts/Dampers Interior Lath/Drywall Frame/Steel/Bolting/Welding Frame/Steel/Bolting/Welding Rough Electric T-24 H-Cap Consultation Frame/Steel/Bolting/Welding Rough/Top out Gas/Test/Repairs Underground/Under Floor --r=-2-t.1 Svrr~ 1F e/t> ~ .f lsNIG-- h"VA C,,, s-v.P.Pud-~,0/tref. "77.> --r.s.:c,A.i4! ACT co co co co AP co AP AP PI CO. AP AP AP INSP TP TP TP TP TP TP TP TP TP TP TP TP TP COMMENTS CEIL LITES NOT COMP ND 1 HR OTL@WALL TO PARLL TJI F .. C. PENT WALLS START CORR LIST NO APR PLNS ON SITE CU FOR SINKS UNSCHEDULED BUILDING INSPECI'IQN /j DATE ¥'o/&7 INSPECTOR _£_._;{:L _____ _ PERMIT# fC: :J.t/'/ PLAN CHECK# ___ _ JOB ADDRESS ___ ..;;;Z;;...:Z~t..i...3/...::M~k".~6~&=--Av( _____ , ______________ _ DESCRIPTION _______________________ _ TIME ARRIVE: TIME ---------- CODE DESCRIPTION ·ACT COMMENTS DATE. 4-17-97 LOCATION. 2714 LOKER AV. The building described above has recently completed several tenant improvements. During the walk through of the finals the following Title 24 Disabled' Access Requirements requiring up-grades to comply with current standards were noted in the building common areas. Van accessible parking stall with 8' loading area, identified with van accessible sign. Site parking stalls to be reduced to 100 in count. 4 H-cap stalls on site. Accessible identification sticker at entrance. Restrooms counter tops require min. 29" clearance under counter measured from finished floor. Mens restrooms require 18" center line clearance from finish wall or partition for water closets. Mens urinal requires a 14" elongated bowl measured from finish wall 17"max. ht. above finished floor. ADA signs 5' to center placed at strike side of door at restrooms. T-24 signs placed on door 5' to center. Drinking fountains to be placed so that bubblier measures 36" max. from finish floor. MAR-31-97 MON 10:21 NNCC Newport National Construction Co. SOSO Avenkia Eneina:;, Suite 350 Car1sbad, CA 9i008 (619) 431-898~ Fax: (619) 438·2832 -Z, 1 '-1 Lo~R~~ FAX NO. 6194382832 P. 01/03 , .. •, .: .. ' . •: , . • u • • 0 RUSH CJ CONFIDENTIAL FAX TRANSMITTAL DATE: ;d/4;/97 I TIME: /o ~ Z.c::> a ·M TO: 11 M Phr llup:i ... FAX: i}:2_tf!;;-· Dt2>:[1;: t!.4 £ '-:Sd,4~ l3t..D6, f:::,(? .F.I:... FROM: ~t.11 J81Efd.&C;:/ZfziJ • .. NEWPORT NATIONAL CONSTRUCTION CO. If you experience difficulty with this tra"smissic:'"1 please conhtc;t_J;;.:..:.t!'J\-..:. ____ at {619) 431.S981, or send a fax tg (619) 438-2832. Number of page$ including cover sheet 3 .~..:.:""'""''~_:~_R. o -~----T,:I I C O t2. ~ecf1q;,,.,, .. /v OT/(!,€_ rt!,,(!;. .. jf '!..l.t .. ~ ... ;is.!..fd,f)..Q.& .. L~ ... - Messa_~!: ... _Ii..t!(J._"=...."ll.J.I.lj_£(ti1..d ....... e~lf.lf;..~"£_£Lµ 6 4-D._~[.!f.I~--~ .~ .. @:."_"f!i.e"_ ... .Jf.rt.tl...~ ..... " 49./-J 61:£:.4-..?2.t?~.L".---~Yl1!~ __ : ..... _, _____ ,, _______ """"_, .. ,., .. --., .. " ...... , ....... . ................. ___ ·----~ ~""'"_J_1.f.:d_ .. 6<R.t:.6.&t""~.&_ """--fJ N G ~;.-"" ........... __ ~_" ___ _ :JTiiJi;~<eL~.--i£-¥ o<L../:uL<!-£_.!UJ.y. .... ~;;;;-;;_,5_-·:= -M•Q~ ____ .(;/:Jt?_Q.Clf.i:!~-• --F---------------------- Tnls mu$ttge is intended on/p f"1" the use if the individual or entity 10· which it is adtb~sed and may conlai-,, i,iformation that is privileged, confidential and extm1p1 from disclosure urtdftr applicable law. If the reader of thi8 me,sage is 11or rhe imended recipient, or the ,employee or agent re.spQ,ts/ble fer delivering t/tfl mes;sage lo the intoukd reciple,u, )'Otl cue hereby notified that ncu, dissemination, distri.bulion or cap)ling of this commu'1ication ls strictly prohibited Jf yau hCJVe received thu t:ommu,ricotion in error, please nolljj> u:, immediately by telephone <,md return the original mu~ase to ~ czt the above addru.s via the U.S. Postal Service.. Thank)IOU, C'1"J o, ....___ I C"J, 0' 0,.. I C"J ' ('1") I co. C"J I C0 I M' ~· o:>' __., co' I I c:5, :Z:' I :x:• <C' [..I...' I I I I D ~ J DA c_ YPP-os : i~ ~o'-i=i\~ ~(.l~1-~!Y·~-r 2 7 '4-j__D K-fz. l?, 1f"\J fl_. Pe.~11--\ i1 #:-~ {o 6-ii 4- 0~iu s tbl'QJ:> 5LH'TJi;. (DO J'J ~4 r C--r~ & -A f '~•·-, • _,,.,__,. . ._-•..,."*-.~--;,·•--:.:=::-:-:-:-"7:-::::--::,.;:~.-_-:---::.-·;--••-~-===========::::::!::::~:-::::::.:-:.:-::::: -~ ,_,. ___ .. ~ W • ,,. n • •"'I W . t q 1/1,'' o.e w~/-D'1.tu.4b ltOf.~ ~ Typ. ""' J.f::,-. X. II ?J' } 51& Ut-1 ~ ~-rru+ ~ 1 tt' ., ' s; 1 • • ' ti' r FAA Co\l 0N, ,T ,so 1~~ ~ (.\l · ¾u Alt. TJI~ I',:.. .• • l_ ' ----------~--l ~-(----···---···--~··-· .... --~ •. -r:~~a\~ ~'EtLU-:.~·7 ~j/d., ;,)ul"J7 B'-l.o (I A-f=F Quality Commercial & !ndustri~I 24 Hr. Se_rvke Air Conditioning• Refrig€rat,on • Heatmg . N c...~trKc«!.11. Nn. 43711.l J: I) ill lo-< :z; -i a z 3 lil C1 :x: . t, fJJ (J) H Cl :z "1 "" Ut fl,. "" ~ 11> 0 ; GVPR6S-27t4tOKERAVr.. SUITE 100. -,_ ·, --______ ]._5J:_l.o_u_r_S~i::-,:.i.c::.~:_(6J.9L469~J8_F.A..X.(6.'.l9l.46S:-7-62.1.----· ~ ------·--------_ ___:, ________ ::.. _____ .:,__. __ . --· ~ .-----. -.· -GRU.Tfl! SAN DIEG@ r-0) I -C'0 ~ ~ 1::::\oT. Io ScAl.:L. --·--.... . -···-------···----------. -----·--- " 'ti AIR CONDfflflNINfi CO. G) .. _ S141 Center St., la Me~a, CA 92041 ------__ ... -··--------··----·-· -. ---·-. ··---. - MAR 05 '97 09:21 MAGGETTI ELAM ASS0C. I r I I I i . 2."-U:f:. ~ ~-". .. " P<::iP.TS. e··· I r. I I r.-:·~~-• • . i I II 1'T't'e )(· . ~ 5{a.: ... ·--· ·- ,, . -~~e..:~o.: .. ~.-s;s. wl ... . ~I!!, ij...iY'f"'e ')( Pf:2'1'+J ... ··-F-A .. see. . .. : " : ~~ CYPROS 2714 LOKER AVE. SUITE 100 NTS3/5/97! TOP Of WALL CONDITION PARAJ,.LEL TO FLOOR FRAMING' -DETAL IN REFERENCE TO WALL SECTION (D/03). IIAGGITTt ILA• •••oc, .. , •• ' 3100 CA"!IHO DEL RI SOUTH SUITE 20T SAN OIIG CA 9210, FINAL BUILDING INSPECTION DEPT: BUILDING ·ENGINEERING FIRE PLANNING U/M WATER PLAN CHECK#: CB962114 PERMIT#: CB962114 PROJECT NAME: 2109 SF-NEW WALLS,LIGHTS,CEILG HVAC,PLUM-OFFICE/LAB-CYPRO ADDRESS: '2714 LOKER AV WEST SUITE# 100 CONTACT PERSON/PHONE#: MW/JIM/PG 960-9345 SEWER DIST: CA WATER DIST: CA INSPECTED /l BY : (!. . 7oa.£d--, INSPECTED BY: INSPECTED BY: COMMENTS: DATE INSPECTED: 3/po/q1 • I DATE INSPECTED: DATE INSPECTED: DATE: 03/07/97 PERMIT TYPE: ITI I By APPROVED f>l... APPROVED APPROVED ~ -] DISAPPROVED DISAPPROVED DISAPPROVED EsGil Corporation Professional Pfan ~view 'E.ngineers DATE: 12/24/96 JURISDICTION: Carlsbad PLAN CHECK NO.: 96-2114 PROJECT ADDRESS: 2714 Loker Ave PROJECT NAME: Cypros the Atrium TI SET:II D ~Cb,_NT ~~ D FIRE D PLAN REVIEWER D FILE D The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's *********** codes. • The plans transmitted herewith will substantially comply with the jurisdiction's building codes when minor deficiencies identified below are resolved and checked by building department staff. D The plans transmitted herewith have significant deficiencies identified on the enclosed check list and should be corrected and resubmitted for a complete recheck. D The check list transmitted herewith is for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. D The applicant's copy of the check list is enclosed for the jurisdiction to forward to the applicant contact person. D The applicant's copy of the check list has been sent to: • Esgil Corporation staff did not advise the applicant that the plan check has been completed. D Esgil Corporation staff did advise the applicant that the plan check has been completed. Person contacted: Date contacted: (by: ) Telephone#: • REMARKS: The owner must provide a letter to the city indicating that trained personnel will monitor and maintain the filtration system for the ductless fume hoods according to the OSHA standards. By: CHUCK MENDENHALL Enclosures: Esgil Corporation D GA D CM D EJ D PC 12/16/96 trnsmtl.dot 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (619) 560-1468 + Fax (?19) 560-1576 EsGil Corporation Professiona[ PCan !l{eview 'Engineers DATE: 12/6/96 JURISDICTION: Carlsbad PLAN CHECK NO.: 96-2114 PROJECT ADDRESS: 2714 Loker Ave. PROJECT NAME: Cypros The Atrium TI SET: II D AP-12Ll_CANT a::J@Js) D FIRE CJ PLAN REVIEWER CJ FILE D The plans transmitted herewith have been corrected where necessary and substantially comply with the jurisdiction's *********** codes. • The -remarks below are transmitted herewith for your information .. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. D The applicant's copy of the check list is enclosed for the jurisdiction to forward ·to the applicant contact person. • The applicant's copy of the check list has been sent to: Barbara Harris PO Box 930, Poway, CA 92074 • Esgil Corporation staff did not advise the applicant (except by mail) that the plan check has been completed. D Esgil Corporation staff did advise the applicant that the plan check has been completed. • REMARKS: 1. The corridor adjacent to the electrical rm must be 1 HR construction. It serves more than 30 occupants. The exception you reference in your response applies to office uses only. The corridor serves lab rms that are not purely office use. 2. There was no description of the operation within the lab. There was no description of the types of chemicals to be used or the quantities to be used or stored. If Class I, II or IIIA chemicals are used in the lab a min of 6 air changes/hour is required within this space. 3. Provide the UL listing number for the self contained fume hoods or listing from some other recognized listing agency to verify that the hoods comply with the UMC and UBC for extraction of toxic or flammable vapors. 4. Provide page 4 of the information sheet from Toxicap. This sheet apparently includes the test standard and the limitation of materials. By: CHUCK MENDENHALL Esgil Corporation D GA D CM D EJ D PC 11/27/96 Enclosures: trnsmtl.dot 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (619) 560-1468 + Fax (619) 560-1576 . . I ~ . ; ·. I . I . i'~ DEC 10 '96 12:29 MAGGETTI ELAM ASS0C . ... EsGII Corporation Professional Plan 1(./,vtr.w 'Enginurs DATE: 12/6/96 JURISDICTION: Carlsbad . PLAN CHECK NO.:· 96 .. 2114 PROJECT ADDRESS: 2714 Loker Ave. PROJECT NAME: ·Cypros The Atrium TI SET: II evee~ . Q JURIS.. . . Q FIRE CJ PLAN REVIEWER CJ Flld:" .. D The pla11s transmitted herewith have been corrected where necessary and substantially_ amply . with the jurisdiction's*********** codes. . ... -.•.. The re'rriarks ·beiow are transmitted herewith·fbr your information .. The plans· are-b_ei~b h Id at Esgil Corporation until corrected plans are submitted for recheck. ., O The applicant'~ copy of the check list is enclosed for the jurisdiction to forward to the; ap licant ' . ~ .•. ·· .. contact person. . . ·: . . . . . • .The a_pplica_nt'.s copy. of the check list has been sent to: Barbara :Harris· · · ..... :· .: .-_: .. : ·. ·· . · PO Box 930, Poway, CA 9207 4 • Esgil Corporation staff did no~ advise the applicant (except by mail) that the pla~, c_heck as : been ~ompleted. · D .E_sgil-Corporation staff did advise the applicant that the plan check has been compl~tel she-:d-DI . . . . . _: ; • · REMARKSd)The corridor adjacent to the electrical rm must be 1 HR construction. It se . es · --.. more· than 30 occupants. The exception you reference in your. res pons~. tip plies t~. qffi.. ._use~ · .. . o~ly. The corridor serves lab rms that are not purely office use.@There was no-d_e~crip ion of the operation within the lab. There was no description of the types of chemicafs-to b_e-u ed-or · the quantities to-be used or stored. If Class I, II 5N IIIA chemicals ·are used in the lab; a· in of 6 . air changes/hour is required within this space. Vrovide the UL listing number for the ;!f · contain~d furn~ hoods or listing from some other recognized listing agency to verify ,hat the· hoods comply with the UMC and UBC for extraction of toxic or flammable vapors.(VPr vide . · page 4 ofthe·information sheet from·Toxicap. This sheet apparently includes the,test st ndard .·_ a~d the ~i~it_a~i~n -~f materials. { ?LL,I ) nfa ~ t-~ ~) . '. ... . ·::· ... :··::--. . . ,·.,: . .. . ; . By~ -·CHUCK. MENDENHALL : · -.Esgil'C~rporation. -.-. . .... · : . 0 GA O C~ 0 EJ D PC 11127/96 Enclosures: trnsmtl.dot : 9320 Chesapeake Drive, Suite 208 + San Dieto, California 92123 + (619) 560-1468 +_.Fax (619) 560-15 6 I . C:.=:~itl..l{..Y~· o~f!..-. ..:!!!!!c~a!.Lr.!.311 sr..n· b!Ui!a~d1.-___ .. _~ , ____ ,;-.:= .... , .. -- 9 11_0 a_1 ~---··---~ Fite Department · • Bureau of Prevention Plan Review: Requirements Category: Building Plan Chack Oats of Report: Wednesday, December 4, 1996 Reviewed by: C! · 1it~,:.L.:;l,=../ __ Contact Nam(:l Address Barbara Harris ==~:..:::.:..:..:.=..--~------~-- Po Box 930 City, State Poway CA 0207 4 Bldg. Dept. No: _96_·-~-,-1_14_· __ _ Job Name _9'pros/Tt1g Atriun_l .. ~ ·--.----........ -- Ste,·or Bldg. No.~~~--,- 0 Approved • The Item you have Sltbmitted for review has been approved. The approval is based on pla11s: lrifonnatlon and/or specification$ provided in yoLir s~bmittal; thereforQ any changes to these Items after this data, including field modifica- tions, must be reviewed by thl~ office to insure continued conformance with applicable codes. Plaa.se r~vlaw carefully all comments attached, as failllrQ to comply with in·structlons In this report can result in suspension of permit to oonstruct Dr install Improvements. ~ Disapproved -Please see the attaohsd report of defioie·noies. Please make corrections to . plans or speclfibatlons necassa1y to indicate compliance with applicable codes ~nd star1dards. Submit corrected plans and/or specifications to this office for review. For Fire Depa.ttment Use Only Review 1st.___ 2nd __ _ 3rd. __ _ Other Ag~MY ID CFO Job#_--'9:::..::6=9=31.,___,_ FIie# __ ~, 2560 O.rlon Way Carlsbad, California 9~008 • (619) 931-2121 . I • ! i . ' ~-------------••nM•-----•--•-•••••-----~---••-••••-••••-•-•-•••---~-~~-------------~~~----------~-----~- DEC-4~96 WED 9:38 CARLSBAD FIRE DEPT FAX NO. 6199290256 P.03 Requirements Category: Building Plan Check 96331 Dolici0noy lt~m: · Pending 32 Additional R~quirements or Comments 1. lndioa.te type of lt1b operations. 2. Indicated existing fire sprinkler density. 3. ln~loated quantltly of gases. . . Deficiency I/em: Pending· 33 Plan Revision$ Please submit 3 &ets of corrected pl~ns direotly to the Building Oof)artment for routing to the . approprll':l.ta department$, . 12/11/96 14:10 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 • ()!pros Pharmaceutical Corporation Gayle Harpel! Tenant Improvement Coordinator New-port National Corporation 5050 A venida Encinas, Suite 350 Carlsbad, California 92008 Dear Gayle: In response to the facsimile from EsGil Corporation: N0.452 P001 December 11, 1996 CHEMISTRY: Chemists will develop drugs with cyloprotective properties. They will modify commercially available starting materials by using kno·wn chemical reactions to give products wit11 potential medicinal applicability. Such reactions may involve known temp<'Jrary protection strategies ~)f functi()nal groups in the starting material, e.g. acylatio~, ctherifications etc., conversion of functional groups to other functional groups, e.g. by oxidatio~ reduction, or substitution, and deprotection of temporarily modified groups. All of these reactions will be executed according to or in analogy to literature references. The purification of reaction products will involve washing and extraction procedures, silica gel column chromatography, high pressure liquid chromatography, crystallisation, or distillation. The reactions will typically be performed on a scale 9f a few milligrams to several grams. The-characterization of reaction products will be done by <mtside C(miraciors. PHARMACOLOGY: Pharmacol.ogists will design systems and experiments in which to te~1. the compounds created by the chemistry department. Such ?1Cthities include the maintenance of established cell lines for assessing the enicacy and l<)Xicity of compounds~ using standard published assays for such characterization. Extracts arc made from the frozen organs of rats and are used in enzymatic assays. Some pharmacology assays invol~·e the use. of low level radioactive materials. All pharmacolo!,1)" personnel are trained in ·the use, handling ?IDd disposal of such materials. ·cypros holds current radioactive and biohw..ardous malerials permits. Tf you have any other questions please call. Thank you. Si01c~:~l , 1 ) /} I-WK:_ /c---·· ~ Fredric I. Storch · Manager, Finance & Operations 2?14 Loker Avenue West• Corlsbod, CA 92008 • Tel (619) 929-9500 • Fax (619) 929-8038 ,! l ' ·1 i .: t ! i./ ii I. ,· . . . . DEC-09-96 MON 09:45 NEWPORT NATIONAL.CORP iYl:Jf;,,·~u .L r • ::,a:, '-' .... ·-, , " .. -••. -- Cypros . Pharmaceutical Corporation -· FAX NO. 619 438 0046 P. 02/02 December 6, 1996 Gayle Ilarpell . Tenan~ Im-provcmcnt Coordinator .N¢wport :National Corporation 5050 Avenida Encinas. Suite 350 Carlsbad, Califontla 92008 Dear Gayle: 111 response to the facsimile re: pending rcquirem~nts of the fire depm-tment! Lab Operations: Medicinal chemfatry and pb.arma~ology . .. Quantity of gasses:, Al. a.uy given tin'l.¢ the tisSU¢ culture fa~ility will have two standard tylinders of cm:bo.o. dioxide gM present. ln the general lab~ each heod will have twt,J cylinders ol'nittogcn ga~ i11 itse. Please contac..t m~ with any questions. Thank you. Sin~ly, ~ Fredric l. Storch Manager, Finance & Operation c: File ---- 2714 Loker Avenue West• Carlsbod, CA 92008 • Tel (619) 929-0500 • Fax (619) 929-8038 12/11/96 09:37 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 Ill ~ypros --Pharm.aceutical . . . .,.,,,,,...,· · Corporation Gayle Harpell . Tenant Improvement c,,ordinator Newport National Corporation 5050 i\vcnida Encina~, Suite 350 Carlsbad, California 92008 Dear Gayle: In response to the facsimile from EsGil Co:rporatfon: N0.427 P002 December 11, 1996 2. Laboratory operations: Medicinal chemistry and pharmacology. Should EsGH require a list of chemicals please send them .the chemical inventory which I provided Newport National in October. Should they require a more concise description of the laboratory operations, perhaps F.sG.il can reference the buildout of 2732 Loker Avenue West, Carlsbad, which took place from February 1993 through December 1993. In addition, please notify EsGil that the mechanical drawings indicate 12 air changes per hour in the laboratory. 3. UT, listing number for the self contained fume hoods: E 54 522. 4. Page 4 of the information sheet from Captair.Iabx: · Attached, along with some other · infbnnation. Gail, if there is. anything else Cypros can do t<J speed this process along please let me know. 'Thank you. ~ Fredric I. Storch Manager, Finance & Operation Enclosures c: File 2?14 Loker Avenue West• Carlsbad, CA 92008 • Tel (619) 929-9500 • Fax (619) 929-8038 .. ' '; : i )• ~ .. -.. . ...... ". --~-----. . -· .. -. -.. --·----... , .... --___ .. _______ . ----· ---,:~ . DECc09-98 MON 14:14 NEWPORT NATIONAL CORP FAX NO. 619 438 0046 12-09-1996 11 :27AM FROM . Western Fire-Protection Inc. December 9, 1996 Newport National Construction SOSO Avcmda En¢hlas #340 Carlsbad.t CA. 92008 ATT: Gayle Harpell RE: Cypros Labs 2714 Loker Ave. Carlsbad, CA. D~arGayle, '!'he existing fire sprinkler systenlat the Cypros Lab Facility at 2714 Loker Aw. in U\rlsbad appear~ to bi; .1 gpm'lSOO sq. ft. This density designation is noted on the calculatio'n card on the me sprinkler riser located .at the fu.dlity. This density is consistent with Light Hazard type occupancy as noted in NFP A pamphlet #13 . If you should have any questions, please do not hesitate to call our office. Sincerely. r;~c-:)~ R.em Dunsmore Vice President P. 02/02 P.2 j 7895 CcnV0y Co1.lrt ~ St.Uc 7 = $an t>:lego, CA $2111 c PHONE (619) 495-0109 c FAX (619) 495-0172 ~-/ .. EsGil Corporation Professiona{ Pfan ~view 'Engineers DATE: 11/13/96 JURISDICTION: Carlsbad PLAN CHECK NO.: 96-2114 PROJECT ADDRESS: 2714 Loker Ave PROJECT NAME: Cypros The Atrium TI SET:I 0 APPLICANT UURI~ 0 FIRE 0 PLAN REVIEWER 0 FILE D The plans transmitted herewith have been corrected where necessary and sub~tantially comply with the jurisdiction's *********** codes. • The remarks below are· transmitted herewith for your information. The plans are being held at Esgil Corporation until corrected plans are submitted for recheck. D The applicant's copy of the check list is enclosed for the jurisdiction to forward to the applicant contact person. • The applicant's copy of the remarks list has been sent to: Barbara Harris PO Box 930, Poway, CA 9207 4 • Esgil Corporation staff did not advise the applicant (except by mail) that the plan check has been completed. D Esgil Corporation staff did advise the applicant that the plan check has been completed. Person contacted: • REMARKS: 1. The occupant load of this tenant space exceeds 30. Exit corridors must be 1 HR const where the occupant load served is 30 or more. The corridor between the Elec. Rm & Open Office inust hav~ 1 HR ceiling. In lieu of this limit the corridor length to 2 X the width. 2. Provide a description of the operation within the lab. Why are the fume hoods needed? What hazardous materials are used or stored within this space? Will the hazardous materials exceed the allowable quantities listed in UBC Tables 3D & 3E? 3. Detail on the mechanical plans the fume hood exhaust and make up air locations on the roof. The hazardous materials exhaust must be 3' above the roof and 10' from all other openings to the building. By: CHUCK MENDENHALL Esgil Corporation 0 GA O CM O EJ O PC 11/5/96 Enclosures: trnsmtl.dot 9320 Chesapeake Drive, Suite 208 + San Diego, California 92123 + (619) 560-1468 + Fax (619) 560-1576 VALUATION AND PLAN CHECK FEE JURISDICTION: Carlsbad PREPARED BY: CM BUILDING ADDRESS: 2714 Loker Ave PLAN CHECK NO.: 96-2114 DATE: 11/13/96 BUILDING OCCUPANCY: B TYPE OF CONSTRUCTION: V lHR BUILDING PORTION BUILDING AREA VALUATION VALUE (ft. 2) MULTIPLIER ($) Tl 2109 26 54834 Air Conditioning Fire Sprinklers TOTAL VALUE 54834 -- • 1991 UBC Building Permit Fee D Bldg. Permit Fee by ordinance: $ 437.00 • 1991 UBC Plan Check Fee D Plan Check Fee by ordinance: $ 284.05 Type of Review: • Complete Review D Structural Only D Hourly D Repetitive Fee Applicable D Other: Esgil Plan Review Fee: $ 227.24 Comments: Fire Services Review: D Complete Review D Other: D Suppression System D Fire Alarm Esgil Fire Services Review Fee: $ Comments: Sheet 1 of 1 macvalue.doc 5196 ,' City of Carlsbad •=hi··; ,t441; n~1-1M-s1;;, ,t4 ;;a DATE: I} --}8-1b BUILDING PLANCHECK CHECKLIST PLANCHECK NO.: CB 96 -2 Jl'-7: BUILDING ADDRESS: 27/Y /pk...llf Ay,.e. PROJECT DESCRIPTION: _.I: -~::;;.._....;_ ______________________ _ ASSESSOR'S PARCEL NUMBER: 2oC/ -08')-0')_ ENGINEERING DEPARTMENT EST. VALUE: 121 1 DDo . APPROVAL The item you have submitted for review has been approved. The approval is based on plans, information and/or specifications provided in your submittal; therefore any changes to these items after this date, including field modifications, must be reviewed by this office to insure continued conformance with applicable codes. Please review carefully all comments attached, as failure to comply with instructions in this report can result in suspension of permit to build. D A Right-of-Way permit is required prior to construction of the following improvements: ATTACHMENTS D Dedication Application D Dedication Checklist D Improvement Application D Improvement Checklist D Future Improvement Agreement D Grading Permit Application D Grading Submittal Checklist D Right-of-Way Permit Application D Right-of-Way Permit Submittal Checklist and Information Sheet D Sewer Fee Information Sheet DENIAL Please see the attached report of deficiencies marked with 0. Make necessary corrections to plans or specifications for compliance with applicable codes and standards. Submit corrected plans and/or specifications to this office for review. By: Date: By: Date: By: Date: -------- ENGINEERING DEPT. CONTACT PERSON Name: David Rick City of Carlsbad Address: 2075 Las Palmas Dr., Carlsbad, CA 92009 Phone: · (619) 438-1161, ext. 4324 A-4 \ILASPALMAS\SYS\LIBRARY\ENGIWORO\OOCS\CHKLST\Bulding Ptancheck Cldst BP0001 Form DR.doc Rov. 8/21~ 2075 Las Palmas Dr.• Carlsbad, CA 92009-1576 • (619) 438-1161 • FAX (619) 438~0894 ~ ~NDJ r. j.f\1"'.e,t i>J' \,.Jr l/4-O"\.',J BUILDING PLANCHECK CHECKLIST SITE PLAN 3RDJ CJ 1. Provide a fully dimensioned site plan drawn to scale. Show: a. North Arrow U). ~ Existing & Proposed Structures E. C. Existing Street Improvements F. 2. Show on site plan: A. Drainage Patterns /Vf}'r!.· Existing & Proposed Slopes C. Existing Topography Property Lines~ Easements Right-of-Way Width & Adjacent Streets ~ Include note: "Surface water to be directed away from the building foundation at /\Jr I a 2% gradient for no less than 5' or 2/3 the distance to the property line (whichever is less)." [Per 1985 USC 2907(d)5] On graded sites, the top of any exterior foundation shall extend above the elevation of the street gutter at point of discharge or the inlet of an approved drainage device a minimum of 12 inches plus two percent." [Per 1990 UBC 2907(d)5] 4. Include on title sheet: c/4. Site address ~-Assessor's Parcel Number ----C. Legal Description For commercial/industrial buildings and tenant improvement projects, include: total building square footage with the square footage for each different use, existing sewer permits showing square footage of different uses (manufacturing, warehouse, office, etc.) previously approved. EXISTING PERMIT NUMBER DESCRIPTION Page 1 of 4 H.IWORO\OOCS\CHKLSl\Buking Plilnched< Cldsl BP0001 Fenn OR.doc Rev. 8121196 0 0 BUILDING PLANCHECK CHECKLIST DISCRETIONARY APPROVAL COMPLIANCE 3RD,1 of\{/P(s. Project does not comply with the following Engineering Conditions of approval 0 for Project No. ______________________ _ Conditions were complied with by: ________ _ Date: ___ _ DEDICATION REQUIREMENTS 6. Dedication for all street Rights-of-Way adjacent to the building site and any storm drain or utility easements on the building site is required for all new buildings and for remodels with a value at or exceeding $ _____ _ pursuant to Code Section 18.40.030. Dedication required as follows: ________________ _ Dedication required. Please have a registered Civil Engineer or Land Surveyor prepare the appropriate legal description together with an 8 ½" x 11" plat map and submit with a title report. All easement documents must be approved and signed by owner(s) prior to issuance of Building Permit. Attached please find an application form and submittal checklist for the dedication process. Provide the completed application form and the requirements on the checklist at the time of resubmittal. Dedication completed by: ___________ _ Date: ___ _ IMPROVEMENT REQUIREMENTS 7a. All needed public improvements upon and adjacent to the building site must be constructed at time of building construction whenever the value of the ~onstruction exceeds $ _______ , pursuant to Code Section 18.40.040. Public improvements required as follows: _____________ _ Please have a registered Civil Engineer prepare appropriate improvement plans and submit them together with the requirements on the attached checklist for a separate plancheck process through the Engineering Department. Improvement plans must be approved, appropriate securities posted and fees paid prior to issuance of permit. Attached please find an application form and submittal checklist for the public improvement requirements. Provide the completed application form and the requirements on the checklist at the time of resubmittal. Improvement Plans signed by: _________ _ Date: ___ _ Page 2 of 4 H:IWORD\OOCS\CHKLS'T\B<ilding Plancheclc C1ds1 BP0001 Form DR.doc Rev. 8121/ll6 0 0 0 0 0 0 0 a BUILDING PLANCHECK CHECKLIST 7b. Construction of the public improvements may be deferred pursuant to Code Section 18.40. Please submit a recent property title report or current grant deed on the property and processing fee of $ _______ so we may prepare the necessary Future Improvement Agreement. This agreement must be signed, notarized and approved by the City prior to issuance of a Building permit. Future public improvements required as follows: Improvement Plans signed by: Date: ---------- 7c. Enclosed please find your Future Improvement Agreement. Please return agreement signed and notarized to the Engineering Department. Future Improvement Agreement completed by: Date: 7d. No Public Improvements required. SPECIAL NOTE: Damaged or defective improvements found adjacent to building site must be repaired to the satisfaction of the City Inspector prior to occupancy. GRADING PERMIT REQUIREMENTS The conditions that invoke the need for a grading permit are found in Section 11.06.030 of the Municipal Code. Ba. Inadequate information available on Site Plan to make a determination on grading requirements. Include accurate grading quantities (cut, fill import, export). Bb. Grading Permit required. A separate grading plan prepared by a registered Civil Engineer must be submitted together with the completed application form attached. NOTE: The Grading Permit must be issued and rough grading approval obtained prior to issuance of a Building Permit. Grading Inspector sign off by: Date: ---------- Be. No Grading Permit required. Page 3 of 4 H:IWORD\OOCS\CHKLS'l\&.ilding Plancheck Cld.t BP0001 Form DR.doc Rev. 8121196 BUILDING PLANCHECK CHECKLIST MISCELLANEOUS PERMITS 9. A RIGHT-OF-WAY PERMIT is required to do work in City Right-of-Way and/or private work adjacent to the public Right-of-Way. Types of work include, but are not limited to: street improvements, trees, driveways, tieing into public storm drain, sewer and water utilities. Right-of-Way permit required for: A separate Right-of-Way permit issued by the Engineering Department is required for the following: 10. A SEWER PERMIT is required concurrent with the building permit issuance. The fee is noted in the fees section on the following page. 11. INDUSTRIAL WASTE PERMIT is required. Applicant must complete Industrial Waste Permit Application Form and submit for City approval prior to issuance of a Permit. Industrial Waste permit accepted by: Date: 12. NPDES PERMIT Complies with the City's requirements of the National Pollutant Discharge Elimination System (NPDES) permit. The applicant shall provide best management practices to reduce surface pollutants to an acceptable level prior to discharge to sensitive areas. Plans for such improvements shall be approved by the City Engineer prior to issuance of grading or building permit, whichever occurs first. Page 4 of 4 H:IWORDIOOCSICHKLS'ruluiking Plancheck Cldst BP0001 Form DR.doc Rev. 8121/96 1 'J' \ -- ·-~ .t:, ;;;; ~ Q) .c (.) C: . .!.!! 'l. >, >, .0 .0 IN <') .. .. "" ti " Ql Ql .r: .r: t.) t.) C: C: "' "' a: a: ·_. .,/ efD D .PLANNING DEPARTMENT BUILDING PLAN CHECK REVIEW CHECKLIST Plan Check No. CB C/6 -21 \L.f Address Z '7J':( Lokea AvS: :!:hoo Planner Daj 2fl\~~sV2: Phone (619) 438-1161, extension __ _ APN: 709 --02> I -0-ZOO Type of Project and Use: 1.:C ,cle......J ,µ0s\~) , l~~r-J. Zone: ~ , Facilities Management Zone: .....::J> CFO Cin-i Circl (If property in, complete SPECIAL TAX CALCULATION WORKSHEET provided by Building Department.) Legend · Item Complete Item Incomplete -Needs your action Environmental Review Required: YES._ NO ~YPE __ _ DATE OF COMPLETION: ______ _ Compliance with conditions of approval? If not, state condi.tions which require action. Conditions of Approval Discretionary Action Required: YES NO VT°YPE APPROVAL/RESO. NO. ____ __,DATE ___ _ PROJECT NO. _______ _ OTHER RELATED CASES: ___________________ _ Compliance with conditions or approval? If not, state conditions which require action. Conditions of Approval -Coastal Zone Assessment/Compliance Project site located in Coastal Zone? YES NO/ If NO, proceed with checklist; if YES, proceed below. Determine status (Exempt or Coastal P·ermit Required): If Exempt, proceed with checklist; if Coastal Permit required, hold building permit until Coastal Permit issued. Coastal Permit Determination Form already completed? YES NO If NO, complete Coastal Permit Determination Form now. Coastal Permit Determination Log #: Follow-Up Actions: 1) Stamp Building Plans as "Exempt" or "Coastal Permit Required" (at minimum Floor Plans). 2) Complete Coastal Permit Determination Log as needed. : . ' -~',·.· t' ; ; .; .,." ' . J! 1·l-"" ""' r·t : o·o ~. D rio D ~i ./i···•o, oi[: ~j2] D Ero o lnclusionary Housin_g F~e required: YES NO -~ . . . ---... -, ·(Eff!:!ctive date of ln.plu~ipn_ary Ho1,1sing Ordinance~ May 2a, 1'9~3.) Site· Pl~n :. -. .-1-.t .... ,.J 1 . Provide a folly dimensional .site .plan _dr:awn1 : t~ scale: Show: North arerow, . pro·perty lines,: easements, .e~is1}.~9:. anq :propos~d:·structures, streets, ~xisting:_ .str~e.~ ir:np·rov_e.111eli_tsr1 ;ri~~t;:6r~yvay,;. wi'ptb, dirne·nsional setbacks ar,,,d:. exis;ting toJ>bgta~J,i.cal ·lirifes·., ·.. · · ·: · · '-.. . . , 4. Provicle le.gal description of property and assessor's parcel number. · Zonin9::· 1. Sefba~ks: Front: Required Shown --,-,------,-----'--------l'nt. Side: Required .. Shown ------Street Side: Required : Shown --------' Rear: R~qui'red Shown 2. Lot Cqvera_ge: .fl/1t . ftequiret;l · Sh.own------ !3-. Height: ,v/1} Required Shown---,-------- 4. Parking: Spacei; Requirec:1· _ Shown ------ ~. _Guest·Spf:ces Required . .. Shown _____ __ D. · Additional Comm~nts . i,ik;oa;· -,,CY'pw-i'-vWl,b ~jj OK TO ISSUE AND ENTERED APPROVAL INTO COMPUT,ER ))~ 2r-i,t.uVv DATE J/-~!JL i. City of Carlsbad 96331 Fire Department • Bureau of Prevention Plan Review: Requirements Category: Building Plan Check Date of Report: Wednesday, January 15, 1997 Reviewed by: (!_ · 13a..flcil-- Contact Name Barbara Harris Address P o Box 930 ------------------ City, State Poway CA 92074 Bldg. Dept. No. 96-2114 Planning No. Job Name Cypros/The Atrium Job Address 2714 Loker -------------------Ste. or Bldg. No. ____ _ ~ Approved -The item you have submitted for review has been approved. The approval is based on plans; information and/or specifications provided in your submittal; therefore any changes to these items after this date, including field modifica- tions, must be reviewed by this office to insure continued conformance with applicable codes. Please review carefully all comments attached, as failure to comply with instructions in this report can result in suspension of permit to construct or install improvements. D Disapproved -Please see the attached report of deficiencies. Please make corrections to plans or specifications necessary to indicate compliance with applicable codes and standards. Submit corrected plans and/or specifications to this office for review. For Fire Department Use Only Review 1st~--2nd __ _ 3rd, __ _ Other Agency ID CFO Job# __ 96_3_3_1 __ File# ___ _ 2560 Orion Way • Carlsbad, California 92008 • (619) 931-2121 'I,, • ,.,,, City of Carlsbad 96331 Fire Department • Bureau of Prevention Plan Review: Requirements Category: Building Plan Check Date of Report: Tuesday, December 31, 1996 ~Ac ~i Reviewed by: / 'L=-~*fd.'i,... ten (!, 8a.£L~ Contact Name · Barbara Harris Address P o Box 930 --------'--------------- City, State Poway CA 92074 Bldg. Dept. No. 96-2114 Planning No. Job Name Cyprosffhe Atrium Job Address 2714 Loker -------------------Ste. or Bldg. No. _____ _ D Approved -The item you have submitted for review has been approved. The approval is based on plans; information and/or specifications provided in your submittal; therefore any changes to these items after this date, including field modifica- tions, must be reviewed by this office to insure continued conformance with applicable codes. Please review carefully all comments attached, as failure to comply with instructions in this report can result in suspension of permit to construct or install improvements. ~ Disapproved -Please see the attached report of deficiencies. Please make corrections to plans or specifications necessary to indicate compliance with applicable codes and standards. Submit corrected plans and/or specifications to this office for review. For Fire Department Use Only Review 1st. __ _ 2nd __ _ 3rd __ _ Other Agency ID CFO Job#_--'-96-'-'3:....::3_.:..1 __ File# ___ _ 2560 Orion Way • Carlsbad, California 92008 • (619) 931-2121 .,, . City of Carlsbad . 96331 Fire Department • Bureau of Prevention Plan Review: Requirements Category: Building Plan Check . Date of Report: Tuesday, November 19, 1996 Reviewed by: ~~ pt (!' i}8r4_~ Contact Name Address Barbara Harris 363 Fifth Avenue City, State San Diego CA 92101 Ste200 Bldg. Dept. No. 96-2114 Planning No. Job Name Cypros/The Atrium Job Address 2714 Loker _;.;.c..;._--'---'-..;:::..;:...c..;:_;:_;_ ______________ _ Ste. or Bldg. No. ____ _ D Approved -The item,you have submitted for review has been approved. The approval is based on plans; information and/or specifications provided in your submittal; therefore any changes to these items after this date, including field modifica- tions, must be reviewed by this office to insure continued conformance with applicable codes. Please review carefully all comments attached, as failure to comply with instructions in this report can result in suspension of permit to construct or install improvements. ~ Disapproved -Please see the attached report of deficiencies. Please make corrections to plans or specifications necessary to indicate compliance with applicable codes and standards. Submit corrected plans and/or specifications to this office for review. For Fire Department Use Only Review 1st'----2nd __ _ 3rd __ _ Other Agency ID CFO Job# __ 96_3c...,_3_1 __ File# ___ _ 2560 Orion Way • Carlsbad, California. 92008 • (619) 931-2121 PROJECT NAME BUILDING CONDITIONED FLOOR AREA . '2-Z.. 7t; BUILDING TYPE NONRESID:ENTIAL D HIGH RISE RESIDENTIAL D HOTEUMOTEL GUEST ROOM PHASE OF CONSTRUCTION D NEW CONSTRUCTION D ADDITION Jgj!-LTERATION D UNCONDITIONED (File.Affadavit) METHOD OF MECHANICAL 01 PRESCRIPTIVE . COMPLIANCE ,ICJ,-I :,, • D PERFORMANCE This Certificate of Compliance lists the building features and performance specifications needed to comply with Title 24, Parts 1 and 6 of the California Code of Regulations.·This certificate applies only to building mechanical requirements. The documentation preparer hereby certifies that the documentation is accurate and complete. DATE Io 31 The Principal Mechanical Designer hereby certifies that the proposed building design represented in this set of construction gocuments is consistent with the other complia·nce forms and worksheets, with the specifications, and with any other 'culations submitted with this permit application. The proposed'building has been designed to meet the mechanical 1uirements contained in sections 110 through 115, 120 through 124, 140 through 142, 144 and ·145. Please check one: D I hereby affirm that I am eligible under the pr9visions of Division 3 of the Business and Professions Code to sign this document as the person responsible for its preparation; and that I am a civil engineer, mechanical engineer, or architect. ~ I affirm that I am eligible under the exemption to Division 3 of the Business and Professions Code by Section 5537 .2 of the Business and Professions Cod~ to.sign t~is document as the person responsible for its preparation; and that I am a licensed contractor preparing documents for work that I have contracted to perform. D I affirm that I am eligible under the exemption to Division 3 of the Business and Professions Code by Section __ _ of the ________________ Code to sign this document as the person responsible for its preparation; and for the following reason:__,..-..,------------------------- lndicat~ location on plans of Note Block fo~ Mandatory Measures ._I ___________________ __. For detailed .instructio.ns on the use, of this '.and all Energy Efficiency Stand~rds. co~pliance forms, please refer to the Nonresidential · · Manual published by the California Energy: Commission. · · MECH-1: Required on plans for all submittals. Parts 2 & 3 may be incorporated in schedules on plans. MECH-2: Required for all submittals; choose appropriate version depending on method of mechanical compliance. MECH-3: Req4ired for all submittals, but form. does not have to be completed if location of mechanical equipement schedule is indicated on the form per Section 4.3.3. · MECH-4: Required for all submittals unless required outdoor ventilation rates and airflows are shown.on _plans per Section 4.3.4 . NonresldenUal Compllanc;e-Form . July 1995 •, . ~t~OJECT NAME i", '·J_>·:.•· . I ' 'I ! ,.,SYSTEM NAME .~;:_:,:: i ' • ,•'-. . . . ·-l ··\ . . . ' ( X!MlfCONTROL-·:\,~~'.·, ' SETBACK CONTROL l . ISOLATION ZONES; ,l-' i J • r -' ,.: __ -_.,. !': . '';-J;• , . .:· ": ... '•,1•;t, -HEAT PUMP THERMOSTAT? ' ,.\.,-." • ,co-_ ___ ..... _ ·, i ELECTRIC HEAT?• . · .;,{ ... ~->,~'• .............. ,~r .{_,;_'. -.· FAN CONTROL -:' ,:;:-.. . ·.;;,: f°J."',:,,--:• '~"'!-~,,,,_!;'••_-, ; VAV MINIMUM pos,fiON'CONTRdL? SIMULTANEOUS HEAT/COOL? HEAT AND COOL SUPPLY RESET? 1--------------------1, VENTILATION OUTDOOR DAMPER CONTROL? ECONOMIZER TYPE DESIGN AIR CFM (MECH-4, COLUMN H) .HEATING EQUIP. TYPE I HIGH EFFIC.? MAKE AND MODEL NUMBER COOLING EQUIP.'TYPE I HIGH EFFIC.? MAKE AND MODEL NUMBER / I• 1 ·-5 ' I µ/flt i - i iJ/A I·· I :1, .·, •, r::-.1 i I y I f._} I ._N/A i, I .. N l : N .... ,-... N c;. i 6r ; . tJfA : j 1io ~"(t>Jl-0"'-J\t.. A-t...J ~,L. Iµ f=-t-tt-s,:--H--1~". I.O '-....., rnf, I ~ - I ,. • . I· · CODE TABLES: Enter code from table below Into columns above. i HEAT PUMP THERMOSTAT? ' TIME. CONTROL SETBACK CTRL. ISOLATION ZONES I S: Prog. Switch H: Heating Enter number of ELECTRIC HEAT? O: Occupancy Sensor C: Cooling Isolation Zones. i I M: Manual Timer B: Both VAV MINIMUM POSITION CONTROL? Y:Yes SIMULTANEOUS HEAT/COOL?. N:No VENTILATION OUTDOOR DAMPER ECONOMIZER HEAT AND COOL SUPPLY RESET? l .. t:r• B: Air Balance A:'Auto A:Air I C: Outside Air Cert. G: Gravity W:Water HIGH EFFICIENCY? M: Out. Air Measure N: Not Required l o: Demand Control ., I .. N: Natural \.. . ' Nonra~dentlal Compliance Form ' ' I I :::::::::::::=:::=::: ····················· mm'mn111~mg ::::::::::::::::::::: ::::::::::::::::::::: ............... :::::::·::::-·:·--··; :i~ii:::i:l.::::. ·: :: I FAN CONTROL I: Inlet Vanes P: Variable Pitch V:VFD O: Other C:Curve O.A.CFM Enter Outdoor Air CFM. Note: This shall be no less than Column G on MECH-4 . ,, I J PROJECT NAME SY.~TEM NAME j. DUCTTYPE (Supply Return, etc.) DUCT LOCATION (Roof, Plenum, etc.) .. H-Fc-5,-o JvPP1r--ff ru; ;-A.,..;-n L !ft--t,,o I J/ ! J,. I . I I I. : i ' ' ... --~ I I I . I I I ' ' I SYSTEM NAME I, •" PIPE TYPE {Supply, Return, etc.) -1-1-F<::. -S . 0 I f ; ~vfPt.,;f ~ lZti--rva,,,,_; ! ' I ' • .. -::rs I i . I ! i I Nonresidential Compiance Fann DUCTTAPE ALLOWED? y N ~D }gJ D DD DD DD DD DD DD DD DD DD DD DD DD INSULATION REQUIRED? y N BD DD DD DD DD DD DD DD DD . DUCT INSULATION R-VALUE "2' I \\.I ..................... !~!ti ::::::::::::::::::::: it:\[:~;::;::·:~: :::::;.::·.·:::"::: Jll>.'t~!f(f !!!!'F.li:W!!!0 .................... :::::::::::::;;;;;;;; July 1995 PROJECT NAME DATE . I ------------------------------------1---------' ~ . E.M NAr:,\E _ FLOOR AREA 1-tft. -s, 0 1040 NOTE: Provide one c~py of this form for each mecpanical system when using the Prescriptive Approach. I ,. • 1. DESIGN CONDITlONS: -OUTDOOR, DRY BULB TEMPERATURE -OUTDOOR, WET BULB TEMPERATURE ' -INDOOR, DRY BULB TEMPERATURE 2. SIZING: -DESIGN OUTDOOR.AIR -ENVELOPE LOAD -LIGHTING -PEOPLE -MISC. EQUIPMENT -OTHER -OTHER ( PROCESS LOADS, DUCT ) . . LOSS, INFILTRATION, ETC .. SAFETY/WARM UP FACTOR (APPENDIX C) (APPENDIX C) (APPENDIX C) CFM (MECH 4; COL.UMN 4) WATTS I SF (LTG-2) # OF PEOPLE (MECH4;COLUMN E) WATTS/SF f'.IV1c.f~s Lo Ao~ (Desc~be) :511 PPL'{ fAtJ (Describe) TOTALS_ I COOLING ~ 19 0 tCJ ?'?"? 7?- i. 737 '2,\3 4-S-3 (p0J~ 4-Soo I o,S-oo 11?'33 B ~4~1" I I -z.2110 I. 21 1,43 M_AXIMUM ADJUSTED LOAD (TOTALS FROM ABOVE x SAFETY/ WARMUP FACTOR) & (, 3_r_r "3'2-473 3. SELECTION: INSTALLED EQUIPMENT CAPACITY IF INSTALLED CAPACITY EXCEEDS MAXIMUM ADJUSTED LOAD, EXPLAIN DESIGN FAN DESCRIPTION BRAKE HP ""' ht <25 ; -. ' - OTE: Include only fan systems exceeding 25 HP (see §144). Total Fan System Power Demand may not exceed 0.8 Watts/CFM for constant volume systems or 1.25 Watts/CFM for VAV systems. NonresldenUal Compliance Form EFFICIENCY MOTOR DRIVE l, \ I '2,00 11 "l. 7;"!>() CJ KBtu / Hr KBiu / Hr NUMBER PEAK WATTS CFM OF FANS 8 XE X 746 / (C X D) (Supply Fans) - TOTALS I'-------' TOTAL FAN SYSTEM I POWER DEMAND . WATTS/CFM ~c~-.F-,-c-~---G~ January 1995 PROJe_c_T_N_A_M_e ____ -=--+-,,,_, _______________________ ~o-A_T_E ______ · I .:M NAME / '( 'l--). FLOOR AREA r~ -!? , a i+f -3. o (Z3f, I NOTE: Provide one copy of this form for each mech_!l_Qjcal system when using the P~es9riptive Approach . . - 1. DESIGN CONDITIONS: . • OUTDOOR, DRY BULB TEMPERATURE COOLING I "";G I (APPENDIX Cl ~l,, • OUTDOOR, WET BULB TEMPERATURE (APPENDIX C) ' 7/ • INDOOR, DRY BULB TEMPERATURE (APPENDIX Cl 7g ft-- 2. SIZING: -DESIGN OUTDOOR.AIR • ENVELOPE LOAD 14-170 CFM (MECH 4; COLUMN 4) ':33'75~ -LIGHTING • PEOPLE • MISC. EQUIPMENT • OTHER • OTHER ( PROCESS LOADS, DUCT ) LOSS; INFILTRATION, ETC .. SAFETY/WARM UP FACTOR WATTS/ SF (L TG-2) # OF PEOPLE (MECH4;COLUMN E) WATTS /SF fBPe,f.~s Lo Ao 5 (Descrlbe) '2-o 10-z_ bl/3 5'3S"b (:,'()00 14"34 B 6UPPLi FAN (Describe) ,--------, TOTALS 7S°"$"9 ~,, l,j~'f-~ M_AXIMUM ADJUSTED LOAD (TOTALS FROM ABOVE x SAFETY/ WARMUP FACTOR) ·OilllliU [§Ifil_]~ l. SELECTION: INSTALLED EQUIPMENT CAPACITY IF INSTALL~r;> CAPACITY EXCEEDS MAXIMUM .JID - DESIGN FAN DESCRIPTION BRAKE HP - "-' bi, <2.5 ' - ----j I : i OTE: Include only fan systems exceeding 25 HP(~ §144). Total Fan System Power Demand may not exceed 0.8 Watts/CFM for constant volume systems or 1.25 Watts/CFM for VAV systems. Nonres/dentfal Compli{J(ICB Form /p90of) II 12.0vo I KBtu / Hr KBtu / Hr EFFICIENCY NUMBER . PEAKWATTS CFM MOTOR DRIVE OF FANS 8 XE X 746 I (C x 0) (Supply Fans) ' I TOTALS I~----' TOTAL FAN SYSTEM I POWER DEMAND . WATTS/ CFM ~Col_._F_/_C_ol.-G~ January 1995 I 'IVIE.6HANICAI..: .EQUIPMENT SUMMARY: · ., . .MECH-. . . I PROJECT NAME SYSTEM MAKE AND NAME MODEL NO. \.fFl.-5,P flf2.S.i· ?(), l.O~ t-1-f' -'3,0 ~ A,(Ul.;, l "1-, ~8'(cl$ ... o 3 k. .. SYSTEM NAME 1-1-f t.:: • S, O nf, H--f:-3 ,O T'1f .. ·I --. Nonresidential Compliance Form ~ESIGN OUTPUT I TOTAL i (BTU I HR} DFSIGN r,FM RATED EFFICIENCY ECONOMIZER UNITS ALLOWED PROPOSED Y N ! ~I, "2,c," I I t8, 4tJ0 I I I I j I I I I ' I ' • -I I I I I I i I I -I I ! ! I MAKE AND MODEL NO. ........... I -z~ CJ 0 µ} A-' w)p.... iJ/A D Kl DD z+·vi; ~"' wfl.... 1 o. o I P, o D gi DESIGN OUTPUT (BTU/ HR) UNITS ?~, 3Do µ)A- 7-Z., 000 -H-SPF ' ' RATED EFFICIENCY ALLOWED .._, 'A .. -,, 2- ' DD DD-· DD DD DD DD DD DD DD DD DD DD PROPOSED ~IA- 7, 2.. January 1995 ... .:i .~ l • ~ROJECT NAME S .M NAME NOTE: Provide one copy of this form for each mech~nical ·system. SPACE · NO. F'--t.10 ~ CONO. AREA (SF) 1041;1 IZ-3 e, .. ARE'A BASIS t I OCCUPANCY BASIS CFM MIN. CFM ! PER SF (BX C) ' NP,. MIN. 'OF CFM PEOPLE !E X 1 5) I I IS-ltO I : i Ir . I t;" ,I?~ ; ' I . ' . I TOTALS (FOR MECH-2): .... I ___ _, REQ'D. O.A. (MAX. OF DOR Fl I b tJ li>S I DESIGN SUPPLY CFM ....____,II ---____. VAV MINIMUM CFM LARGEST DESIGN TRANS- MIN. MIN. FER CFM CFM AIR --- -- ! . l . i I I Minimum Ventilation Rate per Section § 121, Table 1-F. I Based on Expected Number of Occupants or at least 50% of Chapter 33 UBC Occupant D~nsity. Must be· greater·than or equal to G, or use1 Transfer Air. · , , If zone reheat or recool is used, I must be less than or equal to G, or less than or equal to Total Design CFM X 0.3, or less than or equal l:J · to BX 0.4,· o~ .less than or equal to 300 CFM, whic~eyer is larger. Must be less than or equal to I (if appiicable), but no less than G, unless Transfer Air (Kl is used. Must be greatei.than or equal to (G _. H), and, for VAV, greater than or equal to (G • J). 'Nonresidential Compliance Form January 1, 1995 'I. DUCTLESS PORTABLE FUME ENCLOSURES -LABORATORY TECHNICAL FURNITURE CAPTAIR LABX, INC. -ONE ELM SQUARE, ROUTE 114 -NORTH ANDOVER, MASSACHUSETTS 01845 November 11, 1996 Mr Brian Sullivan Cypros Pharmaceutical Corp 2714 Loker Ave West Carlsbad, CA 92008-6603 Dear Mr Brian Sullivan: As requested, enclosed is our product information outlining the special features and specifications of our FILTAIR and TOXICAP Ductless Filtering Fume Enclosures. These fume enclosures are not ducted to the outside and use carbon molecular filters to filter out toxic gases, fumes and odors. Our Captair hoods have been in circulation worldwide since 1970. Our molecular filters are made up of highly purified carbon and have a filtration efficiency of 99.99%. Captair is the only ductless filtering hood company who regularly submits their filters to be tested by an independent laboratory and who can supply an official Test Report on filter performance. The Toxicap hoods are the only ductless filtering hoods on the market that comply with all relevant safety standards including the new ANSI Z9.5 Laboratory Ventilation Standard and OSHA Regulation 1910: 145, which was established to protect employees from exposure to toxic chemicals below established Permissable Exposure Limits. If you have any questions regarding the enclosed information, please feel free to contact me at 1-800-964-4434. I hope to hear from you soon. s~~u~ David A. St.Louis Sales Technician [m [Eaptalr.O&il2>m~nc. TELEPHONE {508) 975-3336 (800) 964-4434 FAX {508) 975-2730 .J . ! DESIGNED BY SPECIALISTS DEDICATED TO YOUR SAFETY THE S.E.T.R.A.F. STANDARD SAFETY oi= ENCLOSURES FOR T ox1cs us1NG RECIRCULATING A1R F1LTRATJON The use of a ductless filtering enclosure for toxic chemicals is acceptable only if the manufacturer is capable of assuring that during each and every · phase of operation, the filtration of the toxic_s will conform to the regulations issued by those official authorities who are responsible for safeguarding the health of the user. These regulations are very complete and are under constant review. For each toxic they give a very precise "limit value" permissible in the air of the. work place. In USA this limit value is called TLV (threshold limit value), expressed in a volume of toxic with regards to a volume of air, or a number x of part(s) of toxic for one million parts of air(PPM). This permissible value (TLV) expressed in part(s) of toxic per million parts of air (PPM) applies only to one toxic taken separately and cannot under any circumstances be cumulated with the TLV(s) of other toxics. Otherwise, it would be possible by cumulating a number of TLV(s) or to create a volume of gas composed exclusively of toxics with absolutely no breathable air. For this reason, it is generally agreed that the level of toxicity in the air should be as close as possible to zero PPM and only in exceptjol)al and unavoidable cases should it reach the level of the TL V. In view of-these requirements, a ductless filterin'g enclosure must be evaluated in terms of its ability to reduce the concentration of toxic PPM to the lowest possibie point below the TL V or OES and to maintain that level of performance through-out each phase of its operation. Those phases are as follows: 1 During the "normal operation phase" while the filter is in process of adsorbing toxics up to the quantity specified by the manufacturer as the filter's total retention capacity. 2 During the "detecti~n phase" beginning at the moment when the· filter reaches saturation and lasting ·until such time as the detection system provides positive indication to the user that filter saturation has been reached. S During the "security···shut-down phase" beginning after filter saturation has been detected and allowing the user sufficient time to terminate the evaporation-that may be in process within the enclosure. 4 During the "accident security phase beginning after shut-down-is completed and in the case that an unexpected event causes the evaporation of the total quantity of toxic authorized by the · manufacturer to be stored within the enclosure. Ductless filtering enclosures provide indeniable advantages ·such as: no loss of heated air or conditioned air, simple and quick installation, no atmospheric pollution, and total mobility. For these advantages to be realized, however, the user must first be assured of total safety during each of the four operating phases listed above. This must be guaranteed by a clearly defined test in the form of a norm, requiring that the toxic concentration be reduced to 100 times lower than the TL V for phases 1 and 2, 50 times lower than the TLV for phase 3, and to the TL V as a maximum for phase 4 which by definition is an exceptional event of limited duration. This test insures that the recirculated air filtered by the enclosure is completely safe for the user and also contributes to the improved air quality for all the people within the work area. STANDARD CLASSIFICATION TABLE FOR ENCLOSURES BASED ON THE "S.E.T.R.A.F." TEST Concentration~ Phase one Phase two Phase three ·Phase four of the 200 PPM (1*) 200 PPM (1*) 200 PPM (1*) Spillage over the entire surface of evaporations the work surface of the enclo.sure Toxic concentration observed at Toxic concentration observed Toxic concentration observed Toxic concentration observed ·en the exhaust point during the entire after the evaporation of a quantity after the detection system has immediately after the completion en RECOMMENDED en evaporation time of that quantity equal to or greater than the indi-reacted to-saturation of the filter of phase three and during simu-en < ·(grams)· indicated by the manu-cated total retention capacity of and during continuation of eva-lation of an accidental spillage of < SAFE USE -' facturer as being the retention ca-the filter and until the detection poration.tor 8.5% of the total time the total quantity of chemical -' () authorized by the manufacturer () OF THE ENCLOSURE pacity of the filter. system has reacted to saturation (3') of phase one. for storage within the enclosure. of the filter. Duration of the test : 1 hour. I Laboratories (4*) Can be used for Maximum 1 % (2 *) Maximum 1 % (2 *) Maximum 50% (2 *) MaximumTLV I concentrations greater than TLV ~ in the working chamber. II Over 1% to 99,9% (2*) -Laboratories (4') For use only with Maximum 1%(2 *) oftheTLV . II toxic concentrations not exceeding the TL V in the working chamber. Diluter of toxics Ill Maximum 1% (2 *) -Ill Not recommended for use in laboratories except for odors. (1 ') 200 PPM of a toxic chemical corresponds to about double the concentration levels normally encountered in cases of actual use. (2') The observed values (PPM) are to be converted to percentages of the TL V values (PPM), For example, the CCL4 TLV is 5 PPM. Therefore to qualify as a class I enclosure under the phase 2 maximum of 1% : the corresponding PPM value is calculated as 5 PPM x 1% = 0,05 PPM. This maximum value is 100 times less than1he TLV and represents a filtration efficiency of 99,99975 % with regards to the emission of 200 (3*) 8.5% of the total phase 1 corresponds, in reality, to 1112th of the evaporated mass, which, for most cases of actual use, represents an evaporation time of about 6 to 12 months, giving a real time comprised between 15 days and 1 month. PPM. . • The value of 1% of the TL V is the best value that can be obtained under current state-of-the-art technology. (4*) If the total mass of toxic retained by the filter during phase 1 is to be evaporated in less than 3 months, the use of an enclosure using recirculating air filtration is not recommended. ~ [captai"1&:i[Q)~linc. CAPT AIR LABX, INC. ONE ELM SQUARE, ROUTE 114, NORTH ANDOVER, MA 01845 . . PHONE 1 (800) 964~4434 -(508) 975-3336 FAX (508) 975-2730 r I .. THE NEW [ioxi©®~J PRINCIPLE SETRAF TEST RESULTS (Safety of Enclosures forToxics tising Recirculating Air Filtration) APPLIED TO 'TOXICAPS (CCL4 test) See description and ~xplanation of the SETRAF standard on page 4. This test has been performed by.the National Testing Lab (L.N.E.) Test report available upon request. IN FULL COMPLIANCE WITH S.E.T.R.A.F. STANDARD, THE TOXICAPS CAN FILTER OVER 300 TOXICS. Phase Phase Phase Phase l 2) . u 3 _r 4t NORMAL OPERATION DETECTION SECURITY ACCIDENT During the normal During the time During the time Total retention Additional operation tirpe required to allowed capacity available back up capacity indicate saturation to change filters ' Mass of toxic 2325g + 125 g + 198 g -2648 g ! + .275g adsorbed -: TOXICAP 800 I Toxic concentrations Oppm Oppm Oppm Oppm _ discharged in the air Total retention capacity available TOXICAP 1000 : 5296 g TOXICAP 1200 : 7944 g FEATURES COMMON TO ALL TOXICAPS SURFACE FINISHING AND COVERING : All our TOXICAPS are made of a corrosion proof metallic alloy protected with a thermohardening epoxy-polyester coating guaranteed for three years.' Interchangeable and·dismountable structure -60 minute average assembly time. BLOWER : Centrifugal blower with extremely high aerodynamic performance. Located outside the airflow, the motor is protected from any corrosion. Sealed ball bearings. Thermally protected. Operation: 40.000 hours. Epoxy coated aluminium impeller and die-cast aluminium housing. Power supply : 115V-60Hz. Sound level : 50 decibels. GUARANTEE : All our TOXICAPS are guaranteed for one year against manufacturing defects, exceptfilters. ELECTRIC WIRING : All our TOXICAPS are equipped with standard wjripg and are grounded. The TOXICAPS are equipped with cartridge fuses. · UL#M2E068-CF. _ _ • TEST REPORTS : the TOXICAP filtration system has been designed by specialists · according to the S.E.T.R.A.F. Standard criteria. All TOXICAPS are in Class I, which is the highest ( see classification table on page 4). • PREFIL TRATION : Each TOXICAP is fitted with disposable dust prefilter(s) to be replaced once a year. MAINTENANCE : The TOXICAPS have been designed to make maintenance minimal. hi addition to changing the prefilters and filters, a monthly cleaning of all sides is recommended. . , US PATENT N° 4946480 OTHER COUNTRIES RESERVED MODULAR TOXICAP.S : All types of TOXICAPS can be combined to make a single unit: i.e. (31 1/2" + 31 1/2"= 63"), (31 1/2" + 39 3/8"= 70 7/8"), (31 1/2" + 47 1/4"= 78 3/4"), etc. Junction frame: Option ref. optn 60. OPERCUMUM OPTION : For an easier and safer acces to the upper parts of the working chamber; For TOXICAP 800: OPTN 70, for TOXICAP 1000: OPTN 71, for TOXICAP 1200: OPTN 72. TOXICAP 1000 ~-,,·,~",.·,7 ... . 1 I j . t ··1 .. f I I J ~ I .-.;,. l1 f:".' \•. .. ' . . .::: I RECOMMENDED FOR LABORATORY USE HIGHEST POSSIBLE RATING IN THE S.E.T.R.A.F. STANDARD ~l[!oxl@~@ Mf1•1•i ~l[!oxl@®~ Ml•1111i ~ l[!oxl@®@] M=M•M ... 1;., -·_·-:-.. ··+ . '.-:. [toxi@<ID~I ASSEMBLED IN 1 HOUR FOR GASES el fofo.$ \:i~J,uf= FOR GASES AND FUMES ref· Utfo11$.l:l?J.11ifoi r : . DIMENSIONS LENGTH WIDTH Internal 46 1/2" 25 5/8" External 505/8" 35" TOXICAP SPECIFICATIONS FILTRATION EFFICIENCY •••••••••.••.••••••••..•.•••.••...••.....••••••• RETENTION CAPACITY (Ref. CCI 4) •••••••.•.••••...•..•.•••••••....••.••.• WEIGHTOFCARBONFILTERS •••••••.••••.•.•••.•.....••••••••......•••. PRIMARY FILTERS : WEIGHT OF CARBON •.••.••••.......•••••••••••••....• BACK-UP FILTRATION CAPACITY: WEIGHT OF CARBON ..••••..•••••••...••.• CARBON FILTER SATURATION DETECTION SYSTEM SUPPLIED WITH EACH UNIT PARTICULATE FILTER SATURATION DETECTION SYSTEM SUPPLIED WITH EACH UNIT NUMBER OF FANS ••••••••.•..•••.••••••••••.•.•..•••••..•.••.••..•••••• AIRFLOW .......................................................... .. AVERAGE FACE VELOCITY OF AIR PER MINUTE: LOWER SECTION DOOR CLOSED LOWER SECTION DOOR OPENED LIGHTING ............................................................ . TOTAL NORMAL POWER CONSUMPTION (115 V) ••...••.•.•.•••••••••.••..• · MAXIMUM AMP. (115 V) .....••.•...•••••••••••••......••.••••••.•••••.•. SHIPPING WEIGHT •.••••.•..•.....•••.••••••.......•••••.••••.•••••••.. HEiGHT 43 3/4" 561/2" Type C Type NU Class I SETRAF 10800 g (TL V) 76lbs 38Ibs 38Ibs STANDARD EQUIPMENT STANDARD EQUIPMENT 3 333 Cfm 324 Cfm 128 Fpm 125 Fpm 77 Fpm 75 Fpm 2x18W . 265W 2.32A 418 lbs 463 lbs FOR GASES renM!l/:t,\:iuuuf.l FOR GASES AND FUMES ref· U•Mol,\:i111if1ifad DIMENSIONS LENGTH WIDTH Internal 371/4" 25 5/8" External 41 3/8" 35" TOXICAP SPECIFICATIONS FILTRATION EFFICIENCY ••••.•.•.•••....•••••••.•••....••••...•••.•••••. RETENTION CAPACITY (Ref. CCI 4) .......••••.••••••...•.•.•....•... , .•... WEIGHT OF CARBON FILTERS ....••••••••.•....•.•..•••••..•••••••...... PRIMARY FILTERS: WEIGHT OF CARBON •••••••••.••..••••••• : ••••••.••.•. BACK-UP FILTRATION CAPACITY: WEIGHT OF CARBON.· .•...•....•.•.••••••• CARBON FILTER SATURATION DETECTION SYSTEM SUPPLIED WITH EACH UNIT PARTICULATE FILTER SATURATION DETECTION SYSTEM SUPPLIED WITH EACH UNIT NUMBER OF FANS ................................. .-..•.. : ...•.......••• AIRFLOW ..••.••••••••••..•.•••...••..•..•••.•.••••••...•••......•••. AVERAGE FACE VELOCITY OF AIR PER MINUTE: LOWER SECTION DOOR CLOSED LOWER SECTION DOOR OPENED - LIGHTING ••.•.••••.•....•......••..••••...••.....•.•..•••••••••••....• TOTAL NORMAL POWER CONSUMPTION (115V) .......••••••••.•••••••..•• MAXIMUM AMP. (115 V) ..•.•.•.•••.•.••........•.....•.•••.•••....•...•. SHIPPING WEIGHT .••.•••...•.•..............•.•.•...••.••.•...••.•..•. HEIGHT 43 3/4". 561/2" Type C Type NU Class I SETRAF 7200 g (TLV) 50Ibs 25Ibs .· 25 lbs STANDARD EQUIPMENT STANDARD EQUIPMENT 2 222 Cfm 216 Cfm 128 Fpm 125 Fpm · 77 Fpm 75 Fpm 2X 18W 195W 1.7A 352 lbs 374 lbs FOR GASES renM:UJ,\:J·uut:i FOR GASES AND FUMES ref· iM:lt:f.\:i-t,i,ifoi DIMENSIONS LENGTH WIDTH Internal 27 3/8" 25 5/8" External 31 1/2' 35" TOXICAP SPECIFICATIONS FILTRATION EFFICIENCY ....•...•••••••••••••••••....•..•.....•••....... RETENTION CAPACITY (Ref. CCI 4) •.•••..•••.••••.•..•............••....•• WEIGHT OF CARBON FILTERS .....•...•.• -. • ; ••.••..........•••...••..... PRIMARY FILTERS : WEIGHT OF CARBON •••..••...........•....•.......... BACK:up FILTRATION CAPACITY: WEIGHT OF CARBON •.••..•••••.•••.••.... .. 'CARBON FILTER SATURATION DETECTION SYSTEM SUPPLIED WITH EACH UNIT -PARTICULATE.FILTER SATURATION DETECTION SYSTEM SUPPLIED WITH EACH UNIT HEIGHT 43 3/4" 561/?" Type C Type NU Class I SETRAF 3600 g (TLV) 25Ibs 12,5 lbs 12,5 lbs STANDARO EQUIPMENT STANDARD EQUIPMENT ·· ,.: NUMBER OF FANS;.,~-.... '.·· •.. : .•••• :.: •.••.•.. : ......••..••••••••••... 1 . 'AIR'FLOW ·.,: ••.•.• : •.•••• : •••. s •••••• :: .•.••.•......•••....•••••••.••.• 111 Cfm 108Cfm AVERAGE FACE VELOCITY OF AIR PER MINUTE: LOWER SECTION DOOR CLOSED 128 Fpm 125 Fpm LOWER SECTION DOOR OPENED 77 Fpm 75 Fpm LIGHTING ••••••••••.•••..••....•..••••••••••• : .••..••.•...•••••••••••. 2x18W TOTAL NORMAL POWER CONSUMPTION (115 V) .•..•.........•.......•.... 120W MAXIMUMAMP.(115V) ................................................ . 1.06A SHIPPING WEIGHT .................................................... . 275 lbs 286 lbs CHOICE OF.~l[!oxi@®~I FILTERS Choice of TOXICAP filters · Filters type AS and BE are polyvalent for most organic vapors and acid handlings . Nevertheless we recommend: Type of vapors handled f With fume __., 1---w_i_th_o_u_t f_u_m_e_+-_o_r..c.p~art_i_cl_es_-l TOXICAP C TOXICAP NU -Filter type AS for handlings where organic vapors predominate. -Filter type BE for handlings where acid vapors predominate. -Filter type F is used for handlings where Formaldehyde predominates. -Filter type K is used for handlings where Ammonia predominates. • Filter GP is used for handlings with radioactive iodine. A complete selection of specific filters is available upon demand. Please consult us for detailed recommendation. ORGANIC VAPORS secondly acids __., Filter § Filter 8 1------------j 1-----+....:::::....+--~---J-':::::.....j ACID VAPORS ------Filter ~ Filter Q secondly organic vapors --,,,---V V 1-------------j 1-----+....:::::....+------J-':::::.....j FORMALDEHYDE Filter ® Filter @ i------------,__..1------+-=-+----+-=-1 AMMONIA __.. Filter ® Filter @ RADIOACTIVE IODINE Filter @ In full compliance with S.E. T.R.A.F. standard, the TOXICAPS can filter over 300 toxics. A chemical listing of over 600 chemicals is supplied with each TOXICAP. LEADER IN DUCTLESS FILTRATION SYSTEMS 1970-1992 WITH OVER 30.000 CAPTAIRS SOLD WORLDWIDE ,J.2/11/96 09:37 12/11/96 CYPROS PHARMACEUTICAL CORP 7 619 438 0046 08:15 12/11/96 5089752730 11:06 CAFTAI~ LAEX N0.427 P003 002 DESIGNED BY SPECIALISTS DEDIC.ATED TO YOUR S=AFETY THE S.E.T.R.A.F. STANDARD SAFETY OF ENCLOSURE$ FOR T OX/CS USING R~CIRCULATING AIR F1LTRATJON Thil use 0f a duclless Jilterlng enCfosure tor 10xlo cheml~ls Is acceptable only 11 t11e manulacturer ls capabl& ot ru;s1,1t1ttg ttiut during eaQ'1 and every p~a.e of oporatilln, tl1e fillralion ol ~ tr,,xlcs wlll conform to the regulatloos f!ISUed by these olflelaJ authorities who are responsible rot sategual'ding !hit health of the user. 'rhllsl!I r~ulatrons are very complele end are under constant review. For each 1oxic they give a very precise "fimh value' permissible ln th& air of th$ work place, ln USA lhis limit value Is called 1L V (lhrWK!ld limit value), expressect in a volume of toxic w!lh regards to a volume of air, or a number x ol part($) of toxic for one mllllDn parta of air(PPM). This permissible ya111e (TLV) a~rossGd in l)Ql1(s} of loXlr:: par mflllon pane of alr (PPM) awrl$$ only to one ta~ir;: taken separately and Olllll'!Ot under any circumstances be oumulated with the Tl V{s) of 1llher 1oxics. Olherwlse, !\ WOllid be J>Dsslb!e by cumulating a number or il.Y(s) or 10 create a volume Of ~as t:emposad excluslvuly ol toxlll<! l'llth absolutely nc lm,alhab!e ail, f'Qr lhls mason, 11 Is g.meraUy agreed tnat I~ ltmll of toxlclty l11 the alr shOUlO 1)8 as close BS possible to mo P?M am! only in excf1;>1i0rla1 ano 1mavo1da~ ~s should tt reach lhe level of lhe TLV. In vieW of thes& reqwrements, a duClless lllt~lng cndosur& m113t be evalual~ in l8!Tn$ ol 11& 4bllily 10 reduce th& CDllcentration of l1»:ic PPM lb the lowest p(>$$lble point below th& TLV Of oes arid to malnlain that level of perf0rmance through-out each phase of its operaiion. Those phases ate as lollom: 1 D-11ring the "1101mal operation pha88" while, lh& !Uter ls 1n proc~ss of adsorbing tOJ1fct1 up to the quontfty spa~ifi11d by the manu!aeturer as the fllter's total ratan1i1m capaoey. 2. During the "detecUon phase· beginning al the moment when the fllter ieaches saturation anrl lasting u1tti! such llme as tile detection symm pl'Qvl\las positive !nd!catloll 19 ~ ~r that filter $aluralion has been reachell. s 01/l'iJ,g the ~aeurlty Ghllt-dOW!I phw," baginni!ll1 aftGr tllter ;aturatlon has ~een detected and ellowin9 th& llS9f suffli::!ent !Ima to 18!minate 11\e evap<>ration that may be lo ~ss within the Gnciowfu, 4 During tM •aceldent securliy phase beginning aflw snut-down is completed and In th& case !hat an unexpected event causes the eva!)Olatlot'I or the total quantity of toxic authorlzErd by the mam1laQl\lrer to M Slated within lhe encloalJ!8, ' Ouclli,ss fillMng ench:isur~a pl'l)vidlJ i11d9n~l11 ar;lva111ages such as; no lo!iS of he~led air or col11flficned llir. simple alld q1,1ic:k mllllla!ion, no atmosphel'ic pollui!on, and total mobility, For tllese advantages to l>e realized, llowover, tho user l'l'll!St tltst b8 36&1,n'!ld cf tO!al saf91y dUr!!llJ each of tl'le t0\11' 9~rallng ~ lbted ~-This m11st be g1111ran!eed by a clearly defined last in the form ot a norm, requiring that tha toxic conoonttalion ba reduced \o 1 QO littles lower 1han 1heTt.Vf0rp!tase11 l and2tSOtimeslowerthan the TLV for phan 3, and to the TLV as a maximum for phase 4 which by deffnll!0n ls an axceptlonal event of llmited duration. This test Insures that the recirculated air llllerad by the Gl1CfQl!U~ is ciomp!1>1~1y iaf8 /or 1hv user and also CQfl1lib\lle11 ,o the !rr,pr11v~ 11ir quality tor a1! 1h11 peoplB wltllln the work ama. STANDARD CLASSIFICATION TABLE FOR ENCLOSURES /BASED ON THE "S.E.T,R.A.F." TEST P~ona 200PPM {1•) Phase two 200PPM W> Toli~bln¢9ntt0110rT~tN40I i roxto 09PVtntrauon ~1mrveo 1lls llllh!uslpamt~ll1\lflnro i aftart!llt~~f i~nllfy o~apora!ien lffl>lloflllo!®4<11ltt , OCI\IIIIWClt'llfqatvrlhQllthtlndl, -{grams>, f~bythl!'ITTOOII• ( ~ 161111 ratenllon ~ly Of ft,:IUIM UIWl10 l!lq tttl!t11)1)111:ll• ! th• lilltt MO YOI~ th1111819~~ p;ldlyollherater. I ;ys111111.b«$l~I08tl1l!IISOII I o1tbe1111ar. Phase three 200 PPM (f°) 1'oKlc eQnm11rt.1lon 9b;~"" aller too dill!ICliCn &y&lon, hJi r08Cled IQ saturillion Of 1he lilltr ~~ a1.11lng conlln1181l011 cf mi• POia~ lorU'll.oflhiltolillime (3'1 ot ph~ ano. ··------------"-'· --·-4 ........ 4----+---··. • i Meo:fmum 1%(l!;") r MalQm11m 1% (2 'J : l\4a:i:imum 50% {2 ·) ' MaxtmumTLV 1 ~ .. ···--------- RECOMPM:NDl:D SAFE USE QFTkS ENCLOSURe tiibaratorluu (4') Crm be vm tor ~&grwarthal'l'l'I..V ti\ tho WQrl<lnq chamber, ~ ... -·-·-··-...... , .. ,_,,, ............ :_, ________ _ ! ·-------~---· ···-.. -'--+------~-"""''-·-· 11 Maxlmtim1%~·) 1 Ovar1%1D99,9%{2') \~ ' oflhe TLV ,, __ .,....,.,, .. I ____ ,. ................... --,·-~-------·· --H-••" Ul m D!lll!i,ro!~ Not lllC0ml1tMdl!d for u,oill lsborelliries ei:C9J)tforodors. '------''-------'------------'------------1---·-"" .,~·---'---....._ ________ ___. 11 ') 2DD PPM OI a to~ e!lemlr:al -~ 10 !(l>oUl d!rubltt~Mt """""11!¥lloc,lol'Ol5""'mlll!y """'""r.n,d In (3") 8.9% Cl Ill$ IO!BI p1.asa 1 ~ r. n,alil)', 10 1112111 GI Ill! fflP'?'91td nw.,, whlclJ, n,r -- (2') ~~~~~ (l'PM) are to Ile i:onvei10dia ~ ctlM '!t.V vduoo (P'/'MJ. ,~i~e. o!-gw. ~ ...,.,_,mo,1 umo or~~ 10 12 =h., giving• rer.f ~,u ccmp,~ lh9 cct4 n.v 1B 5 PPM, Thl>t'8l018'1 qlll!lify •U ~ I encbM!Ulll:lllllM plJaM ~ ll\WIIIXllol 1%: ~'tliel!l}UllMI t 1ll011ffl. 1!!9corrv~i,gPPMvalUOls Mll:Ul.!tedasSPPl,h 1%• DMIPl'M. 'tlltsnwlmain~a!tlt!a 10011lnea l;i,t•• r.,11 TlV 1!1JC1 lllpnjtlllll~ ~ '"'ll1!00 •~ 911}9,ffl115 "WKll ~ 10 ~ emlsallli1 ol zoo {4') u 1'"' lllW ll!llSG,ii to<~ retained~ th& filler during, ~o 1 is lo Ile IW!lfJC/allld l'I W!III lhan 3 l!IOD!hs, The VSIIH! of 1%cff),~'tLVl!ll'lllr,e,;fyot\JOUlll talllle~..-,,jot-·-.,.n ..... ,...umoi"I')', 1!1<> ..... 91C!ltn"'-.. ~rl",I jd(jlcu/allnge/1 !lllQCo,\l~flOI ,_mlftl!ndod, ~fcaptaln!Jaio~11nc. CAPTAIR LABX, INC. ONE ELM SQUARE, AOUTE 114, NORTH ANDOVER, MA 01845 11t!:J1 t)Uf"\l\lC: 1 l~no\ Q&l::,l.,,iA~,f_ -/t;:OR\ 071.-~~~A J:AV o:;nA\ Q7!=..?7~0 ~ 12/11/96 09:37 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.427 P004 12/1l/S6 08:1S 5089752730 12/11/96 11:07 CAPTAIR LAB=.=X:,.:..-_______ ...,._.,,,,,.,...,. ... 0-03"!"'!. -~ ... ,. .• ,-. __ IMPORTANT SAFETY INFORMATION ON DUCTLESS FILTERING Ftn\1E HOODS ~ i2/11/96 09:38 12/11/96 CYPROS PHARMACEUTICAL CORP 7 619 438 0046 08:16 12/11/96 !:i0S9?52730 11:@7 CAPTAIR LABX N0.427 P005 004 OUC'TI.ESS PORTAet.E FUME ENCLOSURES-LA80RATORYTECHNICAL FURNITURE CAP'TAIA I.ASX, INC. -ON: et.t-1 SQUARE., ROUTE 114 -NORT!-1 ANDOVER, MASSACHUSe'riS 01\,4~ ! SAFETY ST.ANI;)ARDS : DUCTLESS PORTABLE /FUME HOODS Captair LabX, Inc, has been at the forefront of dev~oping standards for Ductless Portable Filtering Fume Hoods because of the very senous te$el'Vations that have existed about their safety. Those concerns have given rise to numet.ous ped'omiance, testing and design :standards tl1at now make it possible for us to provide greater assurances of user safety. The most pertinent of those standal'ds arc as follows: A standard test to certify filtration efficiency and to=distinguish between those fume hoods that me safe and those that are not safe. Reference: SETRAFTEST OSHA 1910:1450 CSA STANDARD Z 316.5 A fail·safe rtlter satunttion detection system to alert the user when the filter is saturated. Reference: . ANSI STANDARD 29.5 CSA STANDARD Z 316.5 A post saturation back .. up system to automatically. take over and provide continued user safety even after filter saturation is detected, Reference: ANSIZ9.5 QSHA REGU~A.IJ:QN t91Q;l45Q This regulation requires that 11all employers engaged in the laboratory use of hazardous chemicals must hriplemen.t a written plan capable of protecting emplo~ from health hazards by ke.eping exposure to toxic chemicals below established permissable exposure limits ( P.B.L. Values)" . The use of 1l1e word "below" is done in recognition of th~ fact that beinJ at the P .B.L. iS in fact a wor¥e case scenario, That 1s because of the possibilio/ of oumula.tfug for a nwnber Qt" different toxics the l>.!.L. concentrations within the same VQltime of air and creating a potentially danierous situation. Also, it is well known that as we learn more about toxic,. the tendancy has been to reduce what was previoulsly considered a safe permissable exposure level. rt ' 1 t 1 -.12/11/96 09:38 12/1:1./96 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 5089752730 11:08 C~PTAIR LABX SETRAJl STANDARD TEST NO.427 P006 005 The only true measure of a ductless portable fume hPod's effectiveness is in its ability to reduce to;;dc emissions in its exhaust airflow, to as close as possible to zero parts pt:~ .million and to maintain that condition throughout all phases or its operation, The basiu ~t t9 evaluate this \7apability is the SETRAF Scan.dam Test. This test establishes different classes of ductless porfJlbie fun1e hoods depending on how welt they can filter toxic air. Pot e;ic.ample, a class One fume hood under SETRAF has to have the capabiltity of reducing toxic emissions to 1 % or less of the UV during the operating and detection phases of operation. This is 100 times less than the TL V. $;St\ STANDARD Z 316.S The new CSA Fume Hood Standard. in Annex~ requires that to be ~table for genenu laboratory use, a ductless fume hood must reduce the toxic emissions in its e::ir.:haust stream to 1% or less of the permissable exposure level during what is called PHASE A 'This phase corresponds exactly to what is identified as phase ONE and TWO in STERAF. The CSA STANDARD Z 316.S also incorporates in section 6.12.3 a design standard similar to that found in the new ANSI Lab Ventilation Standard. ANSI Z9,S The section of ANSI dealing with ductless fume hood design is section 4.12.4.2. It provides for two possible designs. The f'U"St one? whereby when the "working filter". is saturated. a by-pass immediately ducts the toxic air to the outside. The second design provision is roorc appropiate to a completely ductless S)'Stem. Il provides for two sets of filters. One is the working or upsLream filter and the other is the back-up or downstream filter. These a.re $epatated by means of an air space which .is used to sample the quality of air being filtered by the upstream filter. Once any saturation is detected in the air space, the system is Shutdown and the upstream fllter changed. Thi$ ~an be done by removing the saturated filter and in its place putting what was previously the downstxeam filter. A brand new back-up filter is then installed. The above group of standards make it possible to realize the potential advantages offered by ductless ftltration systems without being exposed to the clangers inherent in unsafe desip. To be sure, ductless fume hoods do have limitations in terms of the range of toxics and the quantity of to:dcs that they can handle. These need to be carefully ~ified by the manufacturer and adequate instructions and tra.ininS provided. Within those limitations they can offer advantages in the area of reduced environmental pollution+ energy savings, ancl low01" costs. Our company manufactures the patented TOXICAP system~ Which is the only ductless fume hood that meets all the of the above standards and tests. If you would like to receive additional informl:\tion on the 5tandards or on. the patented TOXICAP, please call our toll free number~ 1(800) 9<>4-4434. ! . i t : i i ! I I I I I I ' I I : ' t : I j I I I ! -J2/11/96 09:38 CYPROS PHARMACEUTICAL CORP 7 619 438 0046 NO.427 P007 12/11/96 08:17 5089752730 12/11/91S 11:08 CAPTAIR LABX 006 Major advance in. ductless laboratory fumehood design BY A.G. CHAMBRE P AOPONeNTs OF ductless filtering enclosures point 10 a number of important advantages offered by these units. 8ene1lts include the possibility of providing protection in 01herwise remote or lnaoc::essible locations, simple an(:! quiok installation, and operat!ng savings through the elimination of make•up air requirements as well as elimination of heated or cooled air loss. Also significant rs that, unlike conv1ilntional vented Mods. the enclosure creates no atmospheric poHutlon, Despite these ~dva11tages there has been concetn on the part of safety engineers and industrial hygienists about possible problems that could occur at the point of breakthtough, i.e .• the point at which the filter re~c;hes saturation. Those concerns revolve aro~nef two Issues: 1} How accurately and how timely can the filtratit:m system be monitored to detect breakthrough? 2) What level of protection is provided by the system both prior to and after breakthrough is detected? Advancements in the design of ductless flltering enclosures rnake It possible tc address these crucial safety questfcns. The design incorporates a special air test chamber \ISed 1 n conjunction with a large bacl<·up filter capacity. This design is so effective that the enclosures have qualified as Class 1 enclosures (1he highest possible tatlng) under the new Safety of Enclosures for Toxics using Recirculating Air Filtration (SETRAF) Standard Test. One such system {Toxicap, Captait LabX, Inc., North Andover, Massachusett&) (Figure 1) locates a , ~ Figure t Toxk;ap syst~m • sealad ,;iir test chamber lmmediat~ly above the prirnary carbon fllter(s). The unit comes equipped with a test kit package that enables the U$er to sample 1he air quality within the air chamber. As soOfl as any measurable toxicity is observed, the user is instantaneously and positively aware of the need for changing the primary filter(s). A back-up or secondary filter is located directly ~ove the sealed air chamber. This back·up . safety filter prev€!nts any toxic air 1hat may be present within the air test chamber from escaping into thEJ room. The back-up filter also prvvides sufficient time to permit the sate shutdown of the system. During this entire process, the system continues to reduce the concentrations of toXic ppm to far less than is allowed by the Threshold Limit Value (TLV}. ibxicap's eomp!iance with the Class 1 requirements under SETRAF ensures that: 1) During the entire time the filter is in the proeess of . absorbing toxics, and op until the u$er obtains a positive identification of fitter satutation, the system r@d\.loeS toxic concentrations ot ppm to at least 100 times less than allowed by ,he Tl V. 2) Following filter saturation and for that period of time normally req~lred to shutdown 1he system, the toxic concentrations of ppm are reduc:ed to at least 50 times lower than allowed by the Tl.V. 3) E'ilen in the 1.1nHkely event of a major accident that would involve the total quantity of toxic authorized to be stored wlthil'l the enclosure by 1he manufacturer, the toxic concentrations of ppm would be kept within the iLV. Toxlcap ls the only duotless fume hood that oomplles with 8NS.1 ~ standard section 4:12.4.2 .............. _ ....... ,.-it. ----------~--.C.;ii . .k. :w; P _,._..,-•,. -' -.12/11/96 09:38 12/11,'96 CYPRDS PHARMACEUTICAL CORP 7 619 438 0046 50:39752730 08:18 12/1:1./96 11:09 CAPTA!R LAEX .. FAcT SHEET: ANSI STANDARD Z 9.5 ND.427 P008 007 The Americnn National St.andards Tnsunue is expected to issue the final version of ANSI Standard Z 9 .5 -sometime in July 1992. The most significant seQtions of this labomcory ventill:uion standnrd as they relate to Ductless Pume Hoods are: SECTION S.16 .. DUCTLESS FUME HOODS ' I "Ductless Fume Hoods that do not meet the requirements specified in Section 4, 12.4.2 shall only be used for operations which wouia nonnally be performed on an open bench without presenting an exposure hn.zm-d.'' SECTION 4.12.4.2 -PANEL AND CAR'iRIDGE ADSORBERS "Panel or Canridge A<isotbers shall be monitored ln one of two w~ys~ (1j A relia.ble :md ncleq~at:ely sensitive monitoring tnst:rument shall be instilled dqwnstxe:im of the carbon bed: The monico..-shnll be furnished with'. a signal Of al~ tO indicnre breakthrough. and shall immedill.tefy divert the air stream tO an installed parallel bed which hllE been regenemred or to atmospere. The sensitivity of the monitor,ing system shall be a predetermined fr:tetion of the TL V of the cont!lminant (s) being idsorbed. (2) Two sets of ·panels or c.utrldges shall he insmlled. One is the wo~king or ~p$tre::un filter ~hich is to be physiclllly separated· from the downstreru-n backup filter. The space between shnll b~ pt:riodically sw:n pled · at time intervals based' on ~perience. The sensid vicy of the detection method used. ,5hall be a' prederennined fraction Qr the TL V of the conc:unin:in.t (s) being absorbed. When bre~ihrough is detec~d on the upstremn filter~ the system shal\ be pfaced on shutdownt nnd the 'filter replru;:ed. The upstrellln filter may he removed and replnced with the c;iownstremn:filter. and ·a·new' filter msUIJ.led downstre:1m.~ In figure one of the n.ttached article • -~~ajor Advance in Ductless Laboratory FumehQod Design" • the Toxicnp filtration ~ys~.J$ ·shown. Clenrly it conforms with Section 4.12.4.2 cited above. It is, in'fact. the·9nly'Qus;1less Fume·Hood available today that does so. The. ~onclusions that we .cari 'dra.w~from ·this is that ac::corduig to , Section 5.16 'of tlie new ANSI Z 9.S St:>.ndnrd ·oruy Toxicap will be :ible to be,.used -fQf protection ~:ilnst toxics. All ·other Ductl~s hoods would only be useci for "operations. which woufd normally be performed on an open bench wii:houi presenting an exposure hazard." Even with. Toxicilp, it is important to keep in mind thatthe .system hns t.t defuied ,: range of11pp1ic;2.tions·which are specified in an operation mariunl. The adsorption propertles- oi the air fl.h:ratio"tf system hos been empirically evaluated for each of the toxic chemi(!als ror which it is recommended by the manufacturer. . ~ ~12/11/96 09:38 12/11/96 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.427 P009 5089752730 08:18 12/11/96 11:10 CAPTAIR LABX I Reprint--------- BEST'S Sl,.FETY DIRECTORY 1991 31st .EDITION HOW THE PROPOSED S.E. T .R.A.F. STANDARD CAN CONTRIBUTE TO AN EFFECTIVE HYGIENE PLAN 0 SHA regulation 1910.14$) requirii:s that all employ. ers cngag1:d ln the labor- atoey USC of hazard9~'S ~hi;mi~I~ ~,:v.;fQp and. implement a written chemical hygii:ne plan no later than 1/31/91. This plan !IlUSt be i:ap~ble of protecting employees from health hazards by keeping exposure to to.-.;ic r:hcmfoals below estab!Ished Permissible Exposure Limits-(l' .E.t. Values). This OSHA requirement tot a Chemical Hygiene ?Ian is C."<pccted to incrca$c the USt: of' laboi-atory tn,e hoods and the need for ducd4Sss m. terlng en~Iosures to supplement the vented h.oods that may alr~ady be in ANDRE G. Cl£AMBRE General M~nagcr CAPTAlR. LABX. INC. North Andover. MA place. Tlic use of ductless hoods. however, will be a.¢<:eptable only if their filtrauQn systems a~ Qapabie of keeptns c;,;posure to toxic <:hemii;at~ . below thi: P,E.L, values. . It is possible to classify du~tless filtertng enclosures base~ on a prQ- posed standardized test called S.B.T.R.A.F. that measures th~ ~ir quality-(resid.ual. toxic PPM)-re. sulting from their recirculating air filtration sysr..:ms. S.E.T.R.A,F. i$ an .a<:ronym fqr Saf,:zy of lanclo$Utc=s for Toxics using Recirculatm.s Air Filtra- tion. It is a proposed standard which Is under evalu~tion beth in the United Stat~ and · in Europe tc protect laboratory p~r.sonnel who use d.uc:tlcss filtering enclosures from ex. .. pQ::;i,ite to toxic air i~ exactly the same way as is intended by the Chemical Hygien.e Plan. Class I enclosures under S.E."f,• R.A.F. are et\pabte of keeping e:c- posyre to toxic chcrnicals below th~ P .E.L. values throusnout all phases of tneir operation. OSHA ReJllllltlott 1910:1450 1'his regulation requires all employers cngag~ fn the laboratory use of hazardou$ eb~icals to develop and carry out the prc11isions of a written c:hcmica.I hygiene plan which is: l. Capab~ 9f protecting emplo~ from health hazards ass<x1ittt~c:t Wit?\ bsurdous ehemic:al:s in that labora- tory. and 2. Capable of asiuring that IaboratQry employees exposure to sueh subs;a.necs is below the Per- missible :xpo2™re Limits {P.E.L.) specified in 29 CFR pan ljtO? sub- part z. Haz:ardous cltemical as used above means any chemical for which there is statlsticully•significn.nt evidence based on at least one study <:onduc:tcid ~ I I . . I I I • I I ' -• 12/11/96 09:39 12/11/96 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.427 P010 5089752730 08:19 12/11/96 11:10 CAPTAIR LABX 009 in accordance wilh establi5hed scien• tine principles thai acute or chronic health effectS may occur in eicpo11ed employees. The ierm health hazard lnc:ludes dicmicaLs whii;h an: cur• einogens, toxic or highly toxic agents. reproductive toxins. irritants. cor• rosives. 51;;nsidzers. hcpatotoxins, nephrotoxins, m:uro1oxins, a;t:nts which act on the hem,uopoieiic;: sys .. terns, and agents which damage the lungs, skin, eyes, or mucous mem. branes. Apf)endices A and B of the Hazard Communication Standard (29 CFR 1910.1200) provide further guidance in defining the scope of health hazards and determining whether or not a therntcal is 1.0 be considered hazardous for purposes or this standard. CMmical Hyglenc Plam The Chemical Hygiene Plan shall Include each of the: following ele• ments and sl\aU indica" 5pectal mea. sures that the employer will take to ensure laboratory "mployee protection; l. Standard operating s,rocedures reiev11nt to safety and he:ilth c:onsid- erations ~o b~ followed when labor- atory work involves the use of hazar- dous chemicals. :l. Criteria that the ,mployer wm u,e to determine end imptcmc:nt con- trol measures to rc:::ducc::: employee Oil· posure to huardous cncmicats in• duding engineertng controls, the use ot personal protecdvo equip~nt. and hygicm, practices; particular attention shall be given to tne selection of con. trol measures ror chemicals ~hat are known to be c..-ccr¢mc:ly h.azardous, 3. A req\1irement that fume hoods and other protective equipment an: f-unc:tloning properly and specific mc-a.sure5 that shall be taken to ensure proper and adequate performance of such equipment. 4, Provisions for employn inror- malion a.1\d training as pre~ribed in subsequent sections ot the regulation. $, The circumstances under which a particular laboratory operation, procedure or-activity shall requite prior api,rovat from the employer or the employer's de$ignee before lmplcrnc:ntation. 6. Provisions ror medical 11Qnsulta- tion and medi<:'-l examinations in ac. cordance with subsequent sections of this regulation. 7. Designation of personnel re- spoqsible ror implementation of the Chemic::&l Hygiene P\an including che assignmcmt of a Cbcml~ Hygiene Officer and, if a,:,propriau1. ~blish- mcnt of a Cheroic:a.1 Hygieni: Com- mitti:e:. 8. Provisions ror addidonal em- ployee protection tor work wiui par· ticulady hazardous substances. These include: ••sclct:t carcinogens/' repro- du<;tive to>1.ins and substan~Q which have a bigh degRC of a,;utc:toxieity. Specific: considerations shall be given to the following provis!.ol.lS whlc:h shalt bc-included where appropriate: A. establishment of a deslgnated area; B. \ISc of containment devices such as fume hoods or glove boxes; C. procedure:a for safe removal or ~ontaminated waste; a.nd O. decontamination pro9Cdu.res. Increased Use of Labonuory. Type Hoods Since 1981 .. prudent practices for handling chemicals in laboratories .. has advocated that the best way to pr~c:nt exposure: to airbQrnc sub- stances is to prevent their escape in• to the working annosphere ·by use or hoo~s and other ventUation devices. OSHA 1910:1450 goes beyond thit general r~ommendalion by esia.b• llshing ~he following basic _rules anli pr~durcs t'or working wltb chemi• c:a!s: l • General Rules {b,) Avoidance of "routine" expo- su~; Vent apparatus which m(f)' dlschrure Ioxic r:hemict1ls (vacuum pumps, dis,- aubs;ancc: with a TL V of' less than SO PPM. Confirm adequate hogd pci-fit>r• mnnc:c: betorc use; keep hood closc:li at all times exc-ep\ when adjustments within the hood arc bcin~ m,1d11: keep mareriats stored in hoods to a minimum and do noc allow them ~o bl~X Y~Jlt!S 0[ air now, 1. Working With Allerglns rmd EmbryotoxJns . (b) Embryotoxins-(J;:camples: organomercurlals, lead compounds,. iormamide): If you are a woman of chlld bearing age, handle these subsrances only In G' hQQd wlw$e salis/aczory perJQr- mance ha3 been conflrmt!d. using ap. propriatt proter:tive ,zppanrl (e.tpe-· <:tally t/ove lo prevem s~in t:orrtot;tJ. 3, work With Chemicals of Moder- are Chronic or High Acuce Toxiciq. (E:tamplcs: diisopropytflurophos .. phaxe+ hydrofluoric ~dd.. hydrogen cyanide,) (c) Location; Aiwa)'s use a hood (previowsfy evrt/ .. uaced co confirm adequaze per/or. mance with «face velocity of at leasr 60 linear Jeer p,n-mim.tlt!!J or otht:r containment devk,: far pror:t:duru which may result in rhe genua,ion of aer<1.w~ or vapor.r containing rite :sub~ stance: trap re/e~d vapors contain- ing fhf! $Ub.stcmce; trap rel~ed va- pors lo prf!venr their dlschargt11 wlrh 1.he hood exhau3t, 4. Work With Chemical, of HEtll 4 Since 1981, ''prudent practices for handling chemicals in laboratories" bas advocated that the best way to pre- vent exposure to airborne substances is to prevent their escape into the working.atmosphere by use or hoods and other ventilation devices. llllariolt cotu11uu, etc.) into loctJl ex- /Joust devices. {n,) Use of hood; f./.tf! the hood for operario111 which might result In relea1e of toxic chemi- fX!i vapors or dust. A.s a rule of thumb, use a hood or other local vemlhuion device wb~n working ·N\th any appreciably volatile a Chronic Toxicfl)l, (Examples: dime• thylmerc:ury and nickel carbonyl, bcnzo.a-pyrtne. N-nitrosodiethyla- mine. other carcinosens). {a) Aceess: Conducr all rransfers ond work with these subsiant:ts 111 a ••controlled area": o r~trlcced ~ess hood, glove box. or portiun o/ (1 lab, de:Slgttated ,., I , ·,>, •'"'••l•~•..f4''f•.--~.,.\l-~ .. ~--; • ..,.~_f.,.(•K"'-"4-•'-1' t; '-.... ~ ..... ,. >•'\ ' ,, > ' •. '•Iv•'•, • • ' ' ' !.,. ~ ' ~ .12/11/96 09:39 12/11/96 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.427 P011 for use of hi~hJy tt»dt: ~tanca. for 'Whiclt all people with accen 11re Q''W<ire of che subttancer being used mid necessary pror:edul'(l8. (<:) NoJKontsminarion/decontam- inacion: Pf'01ec1 vacuum pumps againsf c:on• taminatian IJJI scrubbers or HEPA /iltlt/'$ and 11,m, them into the hood. Decontaminat.e vcrcuum pumps or oe/rer comaminated equipment, in- cluding gl~. in the /toqd before l"flntDving them from the controlled area. Ductless Filterin1 Enclosures Ductless filtering enclosures pro- vide tandeniable advantages such as~ no loss of heated or air condidoned 50897:52730 11:11 CAPTAIR LABX ah', aimple .md qulc.lc installation. no atmosphere pollution, and iocnl rno~ bility. B~ius., df thes~ advanta,es. they are the method or choice Cot supplementing the vented heeds that may aJteady be in piacit to met tn, demands of the Chemical Hygiffl, Plan. :However, the use of a ductless filtering enclosure as a 0 taboratory type hood'' is ac:c:e,:nablc: onJy if the 11Ser is assured that durin; each and ,:,,:ry phase of operation the filtration sysu:m will keep e,cposure to to1'lc dJomic:als .'below mablished P • .E.L. vah.1cH as required by OSHA regu.la'!' tion 1910: 1450. The phases of operation ref erred to above ari:: 1. The Normal Operation Phase dur- 010 Ing whii:h th, tlltet is in process of ab- sorbing toxic:s up cc, th111 quantity specified \,y the manufacturer as the filter's to,at mendort capacity. . 2. The Dffection Phrne beglnnlng at the moment •hen the f"dler reaches saturation and luting undi such dnte .is the detection. system provides positive indiciuicn to the user that filter saturation has been readied. 3. The Sttt:Urll)' Sluu4 Down Phase beginning after fJlter mutation bas been detected and allowins tht user sufficient time .to terminata the C'iaporadon that may be in· process within the enclosure. 4. The Accident Security Phae beginning after shut down is com- pitted and in the case that. an unex • pec;cd event. causes the evaporation STANl>t\.lID CLASSJFlCA TION TABLE'FOR .E.'l\fCLOSURES BASED ON THES.E.T.R.A.F. TEST Pt1a1!0\# Coricantr11110tt !IOI-ovt, ,.,. -· oftM Pnas.r crne Ph11191WO Pl'lase:tlrn surface ol Ill• wo,11 ~~en• "'•~et10n 200 PPM• 8Y$0Qnsllon ~00 •PM• evaoomon 200 J'PM• -..lf.w:eotlllt~ Cius T= co,i,;,.,..,,.114'!' TOXIC go~ To•,c: e0neefltra11on 'l"ollfC ~en1,11110r1 Class A111,:umm11nc11,o ooaerveo ai me ••· Ol)Mf'YIRS after !he QDU~tftfffl\e ~ trftmllCNlll!y "41.1111 pc,111 auMg me 1t'l81'Clllllffl Of • Cl"-'1· a.1ec11on sysram nas 1119( 1111 Cl:llftC(t!IOn QI Sal• Uu al en11re tYaOQre11gn 111'1111 ntv tQual t0 or gr,11er tt8Cl11r:& to sat11n11JOn !)MU. .,, .. arnr dllr-~ i;~c,su,. ,:if 11\a! CllJ&ntrty , v, an 1ne •nUll:llltO 10111 or 1n1 ldlltl and dlil'flll;I 1n; ,~OIi ot an (OtttN>-,nglf:Qlld by ltlll'IIQn CIDIC:ly 01 conc,nuanon of acc:,c,m,lal $0111111',le ol 0-. "111nulllell.lP9t as Irle hllet' ana 1.1nt~ rhe evaocra11011 klr 8. SIMI 1119 IQQI <IUOl'lilY 01 ~ 1111 1'9lltll!On dGCll!:111.11'1 cy~ ftllS or u,9 tohll t,me I Of c:nem1c11 aull'l01,z11a QOaCly Ol ll,9 Mtet reaaaa 10 $111Uratl0n 011a,1an1. t)y "19 m1111nac1Vt•r ol 0'11 fllltr, lor 'f!Ol':IIJI w1tn1n t!le . en:1or;,.,~ Out111,o,, ~ thw!.c:IIIO\IP I M•WtfflUf'II t'¾ I Maxim11m 1~! MIIXtfflUffl ~ 2 M11xV'l\llln Tt,V I Lal:I01410f~ • Cafl-o,eadlOtcon- e-~9"-man TLV. VNE 0,- ,..;.1< '" me ~ ¢t,arntt•• II Maiumum lo/o i 011ar 111!oto99.~ (( t.at:101a1Qnff ' • ol IM n.v. VME Fot use only Wllh toxtC or MAK COIICM!raltOns nol .,.. VNOll'lg Ctl9 -n.v. VME orAMKinlhw~ Cllamtior m Over 1% J Ul (),l..,1l)I' or lOlllCS NO'l~ltlar .... ,ftl'a~ .... c:oOCIOIOOOf'S 1•) 200 l'P~ OI 11 !Q>IOQ ei.-.. e-..-ta Bl10UI ft COl'IC8fl!f8,o" 19-..15 4'Qfffllllll)' lllneetlltllereCI ffl cases 0f actual UM, (2) The 01:IUf'tW -1/ll\les(PPM) 11'9 IC ll9CO-rted IC 00~9"'8Qosol IM TL'/. \IM! or MAI< Vlllt18S (PPM). F9' .it-pl•. 11!9 CCC & n.v IS S PPM TI,e,erote. (31 e s~ of "'" 1q1,;11 nme o1 ~ ol\9 corrt$OO~:s. '" Tflllly, 10 1112 ot me 11Y.-Dor11t1C1 ma&&. wn,c,,. lot mo:r.r a:sses OI actulll uw.. Atnr9""" an avaco,a, tion uma Of 4tl0ul s lO ,2111onini. Qt,11'\Q • ,oe111mo t:emOnafd beeween 1e 48'19 MO t mO/!!tl. • IO Ul.l&bly as I Class I ~,. Ul'\det th• P,,,ase T..o m.bcnlUm ol ,~ ,,,. COi'· re1c,e,,C11"9 P~M val11t IS Cal<:UlaU!d a$$ PPM X ,-. •o.os PPM l'llls lMJ<lrnum VIPII• ,s 100 t,me; Ina 1111111!11 TLV e,,c r~esents a '11trot10tl en,e,e,,ey Of 99. 99$9'5~ ..,,,11 11oaro~ to trlt .m11s,or, ol 200 PPM fha value at 1~ al me T'I..V '/ME! or "'!Al( ,g th• belt yafye '"" Clll,, tie Ol!lla~ Uf\CBT cu,,e111 Stat•OI· th--~ t9!:hno(Qgy (ill 11 111a ICltal ~ ot t01«C 1e1&\tled by !he ftf!er durin,;i l)h•se ane ,s to oe <JVIIOCltalto in less man 3 "'°"'"'I. tl'IO u~ ot III tf'ICtosur, w,n9 r11G<N:Ute'llf\9 .. , flllr$1Qft 1$ tlOI ,_.,.ctecS . .., 1121/22/96 \"p 12: 11 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 NO.139 P002 Chemical Inventory April 22,'96 r: KEY: TbcATIONs·. -- )! AC=ACID CABINET I : CD=CHEMISTRY OE:SSICATOR (1-3) I CS=CHEMISTRY SHELVES 1 EPF!=EXPLOSlON PROOF FREEZ5R I: EPR=EXPLOSION PROOF REFRIGERATOR FC=FLAMMABLE CABINET (1•2) i I CHEMICAL .ACET ALDEHYDE AC:;:Ttc ACID GLACIAi. ;ACF.TIC ACID LITHIUM ACETIC ANHYDRIDE ACETOACETIC ACID LITHIUM ACETOACETJC ACID. LITI-IIUM SAL1", TECH,. 90~~ ACFTONE d6 ACETONE, ACS GRADE ACETON!TRILE ACETONITRJLg. /\NHYDAOUS ACFTONITRll.:f-03 ACl:TY.SPERMlNE TRll-lYDROCHLORIOE ACETYL CHLORIDE ACETYLESTERASE FHOM ORANGE Pl:.EL ACETYLI.ACTOSAMINE(N) SYNTHETIC · ACcTYLS0ERMICINE O!HYOROC! !LORIDE ACRYLAMIDE. FOTI ELECTROPHRESIS AC:RYLONl"rRILE AO-M!X· I\LPHA ADENINE AOENOSINE /\DENOSINE 5'-DIPHOSPHATE POTASSIUM FROM_BIIC1 SOURC~ ADENOSINE 5-0IPHOSPI-IATE AC:FNOSINE DEAMINASE ADENOSINE DEMAlNASE TYPE IX FROM CAL!' SPLEF.N A:::>P ADHENOCORlCOTROFIC HORMONE l'RAG 11•24 AGMATINE SULl'ATE AlBUMlN BOVINE FRACTION V ALCOIIOL, DENATURED ALCOHOL ETHYL KIT lALDOLASF. ALLOPHEGNANOLONE ALUMINUM CHI.ORIDE :AMB£RLITE CG ~O II AMBERL!'fE IR 1 20 + AM8ER1 ITli IRA -100 AMilI::RLITE IHC 50 ....... . ...... .... ..... OTHER FR=FREEZER T=T~RATOGEN FR D=FREEZ!:R DESSICATOR M=MUTANOGEN PR=PHARMACOLOGY REFRIGERATOR PR D=PR DESSICATOR PS=PHARMACOLOGY SHELVES DATE: April 22, 1996 YFC,,,YELLOW FLAMMABLE CABINET -·· ... LOC AT_ION l~MOU~T . FC2 AC CUN ·-·14L ·-- ICAL s°G· AC 5L ·-··· r-· J-i MSD~ FIL~ ¥RC~NOG·' TH_~ . ~~~ I·-~~ ·---i .. YES YES ·---;,t:s ., YES cs YFC FC FC-1 ts FC2 EPR EPR CHE M cs PR/F c2 PR 2sG___ F YEs ···No ~7;,-! 6L -YES -, -·No t· . .M . ••••• , ... ,. I 4L_ __ Y~~---, ~9__. M_~ 1LT · YES ! · 2~ GM__ [.. .. ':.':ES ··-·· . 1·--• ;~°!~iJ~ __ N?-, T: YES · --YES ··t· 100 G .. YES -··r=:YES ··-r-- ;~oG~L ,. -~~f , ·· _YES -=--·: 1 OOMG/foG ... YES -l . --· ____. 30G EPF FRD PR -·· . · i~~~~u J ~i~ _· I . N;-. i ·-·-: ~to~uN·-,~~~~ _j-_-N~-t-·; PR PR·o FRD cs PR YFC PR PS FC2 PS PS P$ PS 1MG YES · I NO _f. _T 11 GM YES : ·12soG ·--. y~s· .L.~o -f : .-_--14 1.L,OO·O· U_-_... ·--;~~ -+-· Nq __ =1 T - I ··---~"y~? r··· NO--tT:M7 _GM____ ·YES ··--·To·x1 '. G .. YES_..=_ N~ . jT00~ ·-· 500G . YES NO ~ ·-· 1·--··; ~~~~ . l" ~~~ -I . . ~g . \ . -, Page 1 l~l/22/96 12: 11 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 NO.139 P003 Chemical Inventory April 22,'96 ,- A_M_1KA_c_1N ___ .;..._ ___________ -1PP_s~o .. -. ;GsoM~_ .. --· YYEEss ··l-.!'lo l!_. __ T_ -/\MILO RIDE I !YOROCHl,OR!DE t AMINO 8f:NZOIC ACID Pf{ DIPS 25G/100G YES NO ' ,_A_M-1N_0_(2-,-H-EX_A_N_O_L_(1_) ______________ -I ·--.. ·-----0 YES. ···, -.. ---1 -· /·-· ·-·1 ·-· 1·-· ·-· '"':_:_::_:_'.:_)._:_~~-N-~_:_o_L1_,, ______________ .......i_t_s ·-=-/soG ... -1. YES .. / ·-=-+-· .. AMINOACEiALDEHYDE OJMETl-lYL ACETAL i i YES j' AMlNQACETONlTRILE HYOflOCHLOR!OE ·-r ·--)-YE~f- ,_A_M_IN_o_A_N_Tl_P~YR_IN_e_r-_·R_El:....:..SA_s_E ____________ -li-=-,. . J -=·.. ..L. ·YES ---:- I- A_M_JN_o_s_EN_z_A_:vi_10_1_NE_D_1_Hv_n_i:t_o_c_HL_O_R_1n_._·!4_> ________ ~C~p~.R -. ls1GGM_ __--_ 1,. "y'XEE.SS --.-.... f .. AMINOB5NZIMIDEAZOI.E OlHYOAOCHLORJO!:. AMINOCAPROIC ACID - ,_A_M_,1N .... 0_0_1:o_x..;.Y_A..,D ... EN_c_s1_N;;_E -------------4,:CF...:RD..:.3..=:D ·-1· !22G5M,1GG . ·.1-~ 'y'. Es··=~ N:O' ... l -=· AMINOOJCHLOJ'IOPYRIMIDINE ,_A_M_1N_o_c_1P_1:_R1_0_1N_e_o_1H_v_o_Ao_c_1-1_t_oR;...;1..;.01:.~----------lf.:..F..:,.R b .. 50MG. 1-· ···-· -·· 1--=~· 1-A_M_1N_o_o_1PH_E_N_Y_LA_M_1_N1:_· _____________ __,i.:,.P_S-_ /2~Q__ ·+-· YE~_ N~ . _. AM:NOcTHYLAM1Not2>-?.·ETHANOL, 99% CD3 1 00GM YES I ,_A_M_1N_O_G_UA_~_110_1_NE_H_Y_P_R_oc_H_!._O .. Rt ... D5 ____________ --I CS·--125 G~--·-1 _:[_~S --=-·· . ·-t_· 1·.. --- /\MINOMF.THYL s1:N21M10AZotE 01HvoRocHLoR1oe c~ sG ,· YES 1-/1-M-!N-·O_M_E_TH_Y_L_-2_1--PY_R_IO-IN_I!_· _..;;... __ ..;....; __________ -lcs·· .. 25 G_ M____ . YES ·-'--·-· /-A-M-,N-O_M_ID-IA_Z_O_L..:..!:_C_AR_B_O_X_A_M_IO_E_R_IB_O_t=U_RA_N ________ -IPS--100MG ·---1---. ·-· - 1-A-M-lN_O_P_lP_C_RI_OI_N_l:_O_IH.;..Y_OR;...O_C_H_LO~R;...IO;...E_....;..;...;.;... _______ --1 ·--· I .. YES ·-'-··· ·-·-· AMINCPROPYL lMIDA7.ClL cs IG --· --YES ·-.. ·-· ·----·. AN'INOPROPYL-J)-N)-1 ,3·PROPANEOIAMINE AMINOSALICYL!C ACID AMMONIA, :Z.OM SOLUTION IN METHYL ALCOHOL -·· . AMMONIUM ACETATE /\CS AEAGE:NT ·-AMMONIUM CHLOR!O~ ::::::::;::"OS .. ""' ~!~Es --ij~oG~----~ ~:; ~-~-~~ 1~- t-A_M_M_O_N_IU_M_M_Cl_L_Y_B_OA_T_E_T_ElTI_/\_H_YO_R_A_T_E _________ +;P.:.,,S -!~ 00G YES NO . I-/\_M_M_O_N_IU_M_M_O_L_Y_!l_OA_TE_T_ETR_A_H_YO_R_A_TE_A_CS-f!E_A_G_EN_T _____ ""EPF___ ] 100 GM -·· . YES -· ··-· . - AMMONIUM SULFATE PS i1KG ·-· ·--YES·-NO ·-· t------------------------1 --· --·· ·--··-· -. ·--· -· J\MMON!VM THIOCYANATE cs 100 GM YES 1-:-:,-::~-:;-~-::_Y_DI!~----------------!~~-: -~~~ : . ·. ~i~ i NO ·_ ! .• :: t-A_N1_sa_t_e _______________ ---1FFcc2 . ___ 215LGM·-.. ·-yYEEss__ -·· ! .. _ ... /\NISOYL(Ml CHLORIDE 1 1-:-:v-'.:-F:_:_;~-G:-:-~-:,-:-~-~~-NM_=-::-~-~-~~-·t_ru_fi_E_TE_s_TE_o ______ ~-1-~PSSt~ -22~-~50:M-:GtN. _~;:-~: .... ·-:_~--__ ·f· -~ ARCAINE SUI.FATE l I-A_R_G·_A_RG_·_LY_S;..·A_L_A_-s_e_R-_G.;;.LY_-P_R_o ____________ -1 FR D -2MG----· YES t NO J ,_:_::_·:~_;_:._:_:_,v _______________ ... ~:...,.~:...:..._-!?_: __ -2!~500:·MGG::--~~: ·--~ y·~-~:··. -Ji~~ .:= AR(H YS-OH 2ACOH FR O _l /\RT~RENOL (NORJ:PINEP!iRtNEl PR D ·-1 G ·--· . -,· ··-· ··-"' . -- 1-A-SC_O_R_BIC_A_C_ID_.......; _ ___; ___________ .+c..;..:_,.:...:s ·-1.sKG · ·-T YES ... __ No ·-1 ··- Page2 1121/22/96 12: 12 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.139 P004 Chemical Inventory April 22,'96 AU£ll:OMYC!N PR j5G : .. ·r250000UN ' ..... BACITRACIN PR YES 100 Gr.JI ; SARIUM HYOROX!D1: MONCHY011ATE cs YES ... ·---YES SSN(9-) DIMEft. CRYSTALLINE cs 5GM -· ... YES 31:KA:>IAMYCIN PS 100MG NO PS .... 250 YES ..... ___ SF.KANAMYC!N SULFATE NO ·-····"" .. .......... cs 25GM F!ENYLOXYCARBONYLOXYIN) SUCC!NIMIOI!. 98% I I . ·-.. !ll:NZALOl!t-lYOE cs 250 ML YES ...... --· .. .. - Bl!NZl:Nl:, FC2 1L YES YES --~-.. I YES R~N7.FNF. TRICARBOXYLIC ACIO ! __ ,.,._ -··-·····No BENZENE TRIC/\RBOXYLIC ANHYDRIDE cs 100G YES . ··--··· ... ---·· ; I --81:NZENETE"fAAMINE( 1,2,4,5)· TETRAHYOROCHLORIDI: cs 1 GM YES I YES j ··-·- Bl:N.!EN!:TRICARBONYL TRICHLORIDE cs 25GM .... --... -··-BEr-ZO!C /\CID cs 25GM YES ... . ... !31::NZOIC ANHYDRIDE SC2 100GM BENZOTR!AZCL·YLOXYTRISFHOSPHONIUM EPR 5GM YES : 1LT···-.. DENZOYL CHLOnlDE,ACS FC2 YES . . ..... . .......... BENZOYL !'EROX:oe. 97% EPR 50GM YES ... .. i ··-·-,___ __ BENZYL ALCOHOL cs 100 ML YES I -·-·--·--..... BENZYL ALCOHOL, ANHYOl'IOUS cs 100ML 1ooc;· ········-~---·--· BEN.::YL 1:1tl0Mt0E FC2 YES NO ... .... -···'" 8ENZYL 8ROMOPROPYL F.THER cs 1G YES , .. _, -·-YES ·-f.~ $EN7-Vt, CHI.OROFORMA7i:, 515% cs 100 GM .. .. !ll:NZVL•SERINE PS 5G 1 ~~i~.:~ r !! ___ .. BENZYLOXY ·!2J· 1 ,3-i'ROPANEDJOL cs .... ·····- 13!:N2YLOXYANILINE(4) HYDROCHLORIDE cs cs .. S!:NZYLOXYCAflBONYL(N)-PYRAZOLE(1 HJ CAriBOXAMIDINE(l J, 97% - BENZYLOXYCAt!BON:YLOXY(N) SUCCINlMIOE cs ... --- BENZYLOXYCARSONYLOXY(N)-6-NORBORNENE-2,3-DICARBOXIMIDE cs 1GM ... , . --·-- BEN.!YLOXYCAl'IBONYLOXY-5-NORBORENS:·2.3-D!CARDCXIMIOE!NJ cs 1 GM cs ·-1 GM--........ ·-- B:NZYLOXYCARBONYLOXY0•Nl·5·NCRl30RNENE-2,3·01CARB0XIMtDE Ac· ..... r· BiCINCHRONJNIC ACID SLN 1L cs YES ..... ··--· 131S(?.-AMINOETHY!..J N,NJ· 1.3·PROPANEDIAMINI: 2GM ... . .. ·····----BIS(DIE-:1-lYLAMIJ\:OI CllLOROrHOSPHINI: cs 1GM YES BIS(OIMETHYLAMIN0l(l ,3)-PROPANOL{2), 97% cs 10GM YES 5GM -. YES -· .. BISC!.Jll'Ht:NYLPHOSPHINO) ?ROPANF.(1,3) cs cs 25GM -... YES ... , .. --,,-----. 13JS{METHYI.THlOJMETHYUiN~)-TOLUENEtP) SU~ONAMIDE, 98% i· ··-· .. 5GM --~ DIS(Tl:t1T-l!UTOXYCARBONYU{1,3)-METHYLl2l·THIOPSEUOOURllA cs " ... ! YES BIS(l RIMETHYLSILYL)ACET AMIDE I EPR .. " YES y ,....,.- EHS(l RIME1 HYLSIL Y!.)TRIFLUOROACJ;T AMIDE 5GM SIS-1,"·H3-AMINOf'flOPYU PIPERAZINE cs· 10 ML I I .. --·---·--··- SL!:CMYCIN SULFATE PR 1MG .. YES-+= BLUI:. 01:XrAAN PS 1G --... YES ----BLUE ·1 i:1 RAZOLIUM ... 100MCf .. ···-·- BLUENSOMYCIN PR : .. ; -·" ,,, ____ .,,, 3oc-ASN-ONP CD1 10G ;=t· • . -. BOC·ASN-ONP CO2 10G cs ...... 25GM YES i .... ····7· i:!OC-GL YCINE .. __ ,._ !loc2 0 EPR 25G Page3 1121/22/96 12: 12 CYPROS PHARMACEUTICAL CORP 7 619 438 0046 N0.139 P005 d, Chemical Inventory April 22,'96 :!ORANE·TETRAHYORCFURAN (1.0M SOL. IN ·rerHAHYOKOf'UHAN EPR 100ML YES BORIC ACID cs 250G BOP.IC ACID ACS REAGCNT --YES 1----------------------+·· ....... ·--+------+------1---.. ···-~e_o_RO_N_T_R_IF_Lo_u_R_1o_e_o_i~_TH_v_1._E_TH_~_A~_-_._Pu_R_1F_rE_D • ...;.R_E_or_sT_IL_L_Eo ___ ~EPR 100ML YES eoRONTRIFLUORIDE·M80H COMPI.F.X Fe 2soML Yes -·-·-No·· ,-e-Ro-M-,N-E-----------------+cs ·· .. ··-···-.-4-so_G ___ .._;1 __ Y_e_s_·--· No" .... · ..... ·-·····-+----,---+-----1-----··· SROMC(1)·CHLOROHEXANE(6) .. 1 .....• YES Sf\OMO(l)-CHLOftO?!aNTENE{5) ! YES ,-L--------,'----l t-B_K_OM_O...;(...;Sl_·P_1:.N_T_E:_N1:-'·(...;.ll ________________ -lEPR 5 GM.. .. . ·-·-i-1_·-_·_··_--_-_··-_...,1,....··_··_· ·----+· ... 9ROM0(8)·HEXANOL(1), 97% EPR SGM YES ! 1--------------------------+ .. ···--!------4------···-......... _ ... . !'.lROM0(6HIEXEN!i:(1) cs 5ML YES BROM0·5·t-!'ENTE!'IE EPR 25ML-. YES ~tl-flO_M_0 ___ 5.-1.-PE-NT-EN_E_. 9-7-%-------------~E:.:.P...:R_;_ __ ..j.5~G°K,1 BROMO-GAMMA-BUTYROLI\CTCNE(.21 cs 25Ml YES ·--- ....... --~ BROMOACETONITRILC Fci"'" . 5G Yes·-.... t----------------------1 ........ ·-··-+------+---··-. BH0¥0ACE:TYL l!ROMICE EPR '100 GM YES :B=RO=M=O=B=U=TY=R=O=N=IT=Rl=LE=(4=}=· 9:7:%::::===================~i-;c:...s.:..... __ ........ =2-=-5~.~ YES. .. BROMOETHYLACETATI! EPR 1G , ~B-RO_M_O_E_T_HY_L_r_H-TH_A_L_IM-!C_E_(N_) ___________ -----+cs .. 25GM .... j·-----i,---- t-t!_RO_M_O_t:_' r_HY_L_-o_,o_x_o_LA_N_e ______________ -lEPR 1_o_G ___ ......;.1-· YES t1HOMoerHYL-f'HTHAL1w.1oe .... ~........ YES :::::~~::: "'"· ~i!2-5G-· ...... ·. ~~~ .. t-s_Ro_1_11o_rH_EN_o_L_B_Lu-'E---------....-------lPR D 1-B_RO_M_O_P_R_OP_IO_N_IT_R_ILE--'-(3;._) -------------....JCS 25 GM ; • 'YES BROMOPROPYL-3-rHtMcTHYLAMMONIUM sf!oMu)e CS · · 5GM ······YES ~-------------------~ ....... . .. .. llROMOf'flOAYLl3) PHTHALIMIDE{NI cs 25GM YES ~-------------------------1-'-.:.....--........ --=-...:...:..---.. -. 8ROMOSUCCINIMl::l!' PS 1 00G YES .... -------· ..... ___ __ NO ... ;----l ·····- -···- .. ... ·-... NO ·····---NO .. NO I I tJl'lOMOTRIMmtvLsl!.ANE CS ·· ·· 25 GM YES t-B-Uf-.F-=R_s_o_L-Tl_N_(_pH-'l)---------------4Ps soo_M_L __ -4-__ Y_E_s··· .... ------0-NOO r I ! NO ---SUFFER SOl.TIN {pH , 0) PS 1.5L YES ~-----------------------ii-'-;__ __ -... -------+----,.- t-'Il_ur_11;_·fl_s_o_L_TI_N..;(p_li_7_) ______________ -4PS 500M_L __ -l-__ Y_E_S ... -•.. £l'~TAN~DIOL·1.4 cs 100 GM YES ~13-~-A-N-OL----------------~FC 4L ...... ___. __ Y_E_S_ \ I-B-lJ-TA_N_O_L(-1)-, -AN_H_Y_D-RO_U_S_,-99-.8-1-,.-----------i.:.F_C;..1 ___ -l.1 LT Y_E_S_-i---- NO NO -· NO -- BUTANOLS FC2 -·12L YES NO ---: ~--------------------i.:....:...:::... ___ NH ·-·------1---.. ···- SUTIROSlN Dl$Ul.FATE YES _L 1-e-UT-, o_x_v_1rr_1-,A-N-0L-r2_1_. s-9-'l(i-------------~·-· -l------_-=.-.;.,_-Y_E_s_· ·· -· ....... . .•. BUTYt.:..ITH:UM, 2.0M SOLL:TION IN PENTAN; :(ES l ..... EPR 100ML .. BUTYRIC ANHYDRIOE YES I BUTYFWL CHLORIDE -...--Y_E_S .... . i --1L FC2 FC:2° 2so G°M - CADMIUM ACE.7AT!: IIYCRATE YE~ ..... --· NNOO .... j.·_ Ct\FFlENE Ct\LCIUM CHLORIDE CALCIUM IIYCR!OE YES CALCIUM HY()ROXIOF +--Y-E_S __ .,_ .... 7· ····- CALCIUM NITflATE TI:TRAHYORATE .... __ --1,-_._ .... , ... CAM KINASE I ··-· cs 25G PS 100G PS 500G cs-· 500G cs ...... 600 GM ... .. PS 100G ···-· O.5MG FR PS 25G ----+--N-0 CAMPHORSULFONIC ACID YES Page4 10/22/96 12:12 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.139 P006 .) ' Chemical Inventory April 22,'96 CAHBAMAZIPINE PR D 127G ~ I r---CARSONTF.TRACHLO-RIOI: -----i--.:--:--FC .. 2-c--·· ~ -YES ·--- CARBQNTl:TRABROMIOE cs 100G ss -· NO ----.. :c:A:.:ls:a:N:Y_L-0:II_M-_-,o=AZ.=· O=L=E:::::::=====:::::::::======~-CS .. 25G cAAB0NvL011M10AzoLec1,11 ·cs ·· :25GM ·· s 1-------.:.......;.... ___________ ~ CELITF. 521 CF.L:TE. 521 cs 11 KG YES I CSAAM><>E FR r:25MG . ... , ·---.. I 1-::=_::=_:u=_CM=_su=_N~=-~A=_R:=_~=-;:_Hr:_:x=_:=_:=_:o:_o~=-A=-~~=_1:=_ -==--==--==--==--==--==--==--==--==--:=_ -=~,4-~_:_·-_·-•. -.-l ~~~~~±----~~-~ ... J -N~ .... --1._ ... ·- CESIUM CARBONATE _J YES I -;: ! 1-~-~-~o-R:-:-:-~;-:a-:-:-t:-:-T:-~A-SH_E_D_UL_E_tv-1--r-1:M ________ --4PS -~(KG ... ! ..... ~:~ -~6 l . -~ CHI.ORIIEX!DlNE ·:-_ _J--,... :~_·r YYEEss--- 1 :· -· · __ t_-= ... CHLOR0(:1.)·2·0X0·1,3,2-DIOXAPHOSPHOlaANE I t r CHLORO!ZJ-OICXAPHOSFHOLANE(1,3,:l)•OXIDl:(2) ,··· .• .J_. . YES .. -l--- 1-C-H-LC_Fi_O_(Z-l,-Nl-TR_C_P_YR_I_OI-NE-(3_) ____________ ,4-___ ··i-·. . j "YES ~-. ~· ·- CHI.OR0·{2)·4H-i,3,2-BENZOOICXAl'HOSl'HORIN-.4.0NE FC2 j!fGM ,_., YES--I .. . .. c11LaR0Ace-:-;cAc1D cs·-11000_.. YES -·· N6--_- :c:HL=o=Ro=s=1::N=2=eN:e:::::=====:::::=====:::::::~,...~-cc_2_ l 510000 MGML .. ... .. YYEEsS·· . _ ··-... "'"! CHLOROBEN7.QYL!4·) CHt.OHlO<: r !Torr :~~ .. i .,_c_H_to_R_o_i:.n_·i_o_xv_-_12_1-.... 2c_eT_H_A_No_L_l,_9!l_'ll_, ___________ F~~:fso"G~... \~ "l'io --~· .. -- CHLOROFORM, ACS GRADE FC l4L YES . MAYBE 1-c-HL_o_fl_oF_o_RM-.-0-. 9-g-_o_"_T_oM_%_0 ___________ -+-cc-:5s-· · /1 1 -o 0 o 0 ~GMM. --~~---.. --f--·-.. --. -~ ~~~ -t cHLariaHEx101N1:: PR o·--25G --·· YES [ No · •· :c:1-1_l-.O:R_O-M:ll:·r=1-i_v-L=F=1v:A=LA:TE::::=========::::========~EEPP_RR _ 2 2 5 5G~MM -_ '"yy· EESS ~.-. : ··· .... j CHI.OROP!:ROXYB!:NZOIC(3) ACID = . ! t 1-i-:-i~-:-~-::-.:-~N_:~~-l:_:G_u_'A_N_1o_e ______________ ~ -i~~~~-· :b--(. CHLOROTITA!lllUM TRIISOPROPOXIOE, 1.0 M IN Hl:)(AN!lS FC2 100 ML ·1 YES . ==i:·· CHl.OROTITANIUM TRIISOPROPOXIOS, 1.0M S01."N IN HEXI\NES FC~-100 ML ; .. I 1-C-,H-LO_R_O_TI-TA_N_IU-M-TR_l_lS-OP_R_O_l'O_X_lD_E_, -1.-0M-SO_L_IN-H-EX_A_N_ES ___ _,f--f-C_2__ j1QOML i •• -... +i ··-· ·- CliLOROTRIMETI-IYI.SILANE,98 FC2 [zsoriilL .. ,-. ··-· ... __ ~:=:=~=~~=::.=. :=:=:l=~:=·:=~=O=Rl=OE=~=========================~J.;.g-~3 -~ !~ ;~ ... ~ ... }~~ .... l, --~~-.. CHOLINE CHLORIOI: CD~. SOGM 1 t-C_H_UL_1111_e_,0_0_1c_E ______________ --lcFCS2 .. --·,,_51 o_GoMG!vt. .: · ·--..• Y~_s j ·--_ . ··.··.·. : ----. __ -·· CHOLORo-21-1,3,2-01oxAPHOSPHOLANc-2-ox1oe I ... CIMETIOINE PS i SOOMG j_, ·- ..,c_1s_-1_,2_· -c_v_c_LO_H_.EX_AN_e_o_1c_A_ris_o_x_v_uc_AN_H_v_o_m_DE_._s_s% _____ -l-c_s_. _ -~----~ =-.. ,_L~·-f--.. ... c_1s_-1_,2_,0_1_AM_1_N_o_cY_C_L_OH_E_X_AN_E_s_u_LF_A_T_E._9_8•_,,. _______ ... cqs~. 51 _KGGM . l ··· YES ··-·· CITRIC ACID I COBALT Ill> Cl-fl.ORIO!: liEXAHYDHATE cs 100GM f YES . -_-:____ --· COBALT{lllJSEl'Ut.CHfiATE TRIC!ILCRIDE cs · I 1 GM _ .. YES ---! I-C-O-LLA---G-EN_S_O_L_UT-lO_N_FR_O_M_C_A_LF_S_K_IN----------1f---.. YES I ·7-··-• I-C-0-M-PO_U_N_O_N _______________ . ---CD1 . ---,400MG _ .. . ... _ _:_~ .. I; . ·- CONOTOXIN M VI!A Pi:fc,-·--1.5MG I ·--·· Page5 112)/22/96 12: 12 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.139 P007 Chemical Inventory April 22,'96 COOMA$S1E 6LUE PS 1 OG I _ l j 1-:_:_::_::_;.,;;::,_~_:;_~:_':_,~_e _____________ --1-C~S~ -. ~ :1·00GGG¥rM. . •. i Y~E:S~ fr~·:--~~+! .... ·-- co?P:Rm CHLOR!Oti, 99.995+% t- l-C-0-PP_E_R(_lll_A_C_E1_A_T_...E_M_O_NO_H_Y_O_RA_T_E __________ 4-CS --· 100 GM . . YES--. --.,_ ~~=;:=P=ER:m=> s:u:Lf:A..-:,e~====~:===================~~~-/C_D_3. ;~~100~-l -·· -· 1-=- 1-C-RA_G_O_F.--L--S-4-1,-1-,1-----------------'c;i51 . 10MG .. --1 --.. -.. . .. 1-C-tiO_M_O_l_YN--'-------------------IPS __ , 1 G ·-· ·-. ··--' .. l-c_Ko_w_N_(_1s_1-_s _______________ --+,EPR _ _:__ 25 GM ... . YEs·· ·-·· I -· CUMF.NC HYDROPEROXlDE, TECH., 80% 1 ct;Prnc SULFATE PS i50G / · ·-·-.. 1-c_Y_AN_O..;.E·;.;.rH..;.Y,;;.L s;;..u_c;;..RO;;.;S.::.c--~----------+Ep:...p=-SR : 1~·0000GM. L . . yy·E~Ss : -~-NO~= --~ CYANOGEN SROM1DI:, 5,0M SOLUTiON IN ACERONITRII.E CYCLEN PR b ·-1250MG. ·--YES ... . NO-.. _ ~~=·y=~~=::::::=~=R=::=:::::::::::::· P=R:OP=Y=L=(:Z=) c='r=H=EP.================---lp~ -.-. 30~---~j~-~~r-· .. :.~: __ . ~~ 1-:_:c_c~_:_~:_.:_:_::_. s_P_ec_T_Ro~Ac_s ___________ ---4~ ~-:--1~~~~~ . 1 -.-. __ YYE~SS --~ ·· . N?_, 1. ·_- cvc1.oHEXANE01cARooxvuc{1,,1 ANHYORIOF. (CIS) t CYCLOHEXANEDICARBOXYUC(1,2l /\NHYORIOE (TRANS) --I . ·-· .YE'.$ ·-i • l-c_v_c,_.o_H_cx_l\_~_,1:o;:.;1--0.;.;LC...;1'...;4) _________ _,.. ___ -lcs ~-1100GM .. =-1 ·yes r·~~ ... i CYCLOHEXANEOIONE(1,4)-MON0-2,2•01METHYL-TRIMETHYLENE KETAL cs /10 GM +· YES -I - P,., D . =i. 200MG. . , . Y·Es .. . NO · ·-cvcL0HexvLAoeN0s1NE " :c=Y=CL=O=He:x:Y=LA=N=!U=N~E(:4)===========================~c~? --· 5G~ _I -· YE~--! -=~. :=~ CYCLOPEN,YLADl:NOSINE PR D 1 00MG + YES • NO t-l)-.f'-R-UC_T_O_SE-1,-6--0-IP-l-lO_S_P-HA-1_E_T_ETTl_A _________ -+-EPF ··-· 10 GM" . . ·--1 ,_.. ·- 1-o--r-n-uc_T_O_SE_..;.1:-2C_Y_C-U_C_6-_D_IP..:.HO_S.;.i'_H_Ar_e_S_O_DI_U_M ______ --4EPF--!25 MG ·-j--· -. --f-- 1-D-_F_R_uc_r __ o ... sE_6_·...;PH...;o..:.s...;FA...;TE __ . __ o.:.=1s..:.o=.:01;.;;uM;.;.:.;.A.;,;.M;.;;o:.::RP..:.H:::o.;.us;;_ _____ -1.:::EPF _ .. !500 M~ _ ~~---· __ · · ··-1 .. _ O-F'RUCTOSE-1,6-0IPHOS?HATASE rROM AA81llT LIVER EPF 25UN ,_ .. -t' ·-· 1-D-EC_I\_N_OY_L_C_HL_O_n!_DE _______ ...;....;.__::.;.=.;__ ____ -4FC2 . -100 ML--. YES -·· . - 1-0_1:o--: __ <Y_-o_-G...;,L--u_co.;,.s:;;e;.._ ______________ -1PR~---· 5G -· _----.. y· ES·:--____ .. ---+· ·-·· OEOXYCYTIOINE HYDROCHLOl'IIOE OEOXYSTi11:Pl'AMIN5 Hor PR___ 100MG ·-.. ·-· .. -· ,· ·• t-:-::-1~-.;-~-:-:~-;-H\-Ho-L~-;c-1:_:_on-,o-1: _____________ -1CCp:S D ... ·.15~0;GMM .... -~: .. -~~: . 1· .. ··NO -.+r:-... ·- oi:urERIUM ox101: YES J. 1-:-:~-:-ER_;~-M_ox_1_oe...:;..;.ss_.s;..A_T_o_M...;%.;..D;;..... _________ .,4~. --1;:rM . ·- 1 -YES·· _ N~ -+· ·· DE:XTRO$E cs . ··-r2KG·-_ -.. i-YES.. r,j'o' / ·- D1(ETHYLEN5GLYCOU, 99% cs ·-· .. 11KG . . . ·--·-· ··- 1-0-,--TE-fl-T--BU_T.;..Y_L_OI-C-AR..:..S.;..O_N_AT_E_, 9-9-%------------+,EPR --· 10GM . . --.. -. ·t·· :G=I-T=E=RT=-B=U=T=YL=-D=IC=A=P.=BO=N=A=ic=======================~cEPSR-· _2._1 O~GMM_~--. .. YES f·. . --~ -~ OIAMIN0(3,5)-l"RIAZOLE(l,2,4),98% ~ YES DlAMIN0-6-HYOnOXY·MITHYLPERIOINE PPRR .. DD __ ?-255MG_G .. ··_YYEE.SS ... I 'NNoO·-. ~i-·-. DIAMINOSENZOIC /\CID ::=::=:=::=:=:=:=~=:=:=E~=·:=N=ec=1.=2>=CT=RA=:N:s,====================~---_-, -, .. ----~~:.i-· ~~~ -~~TL:-·:~··: · _ _:_ 1-o-,A-M-1N_o_c_vc_L_O_H_;x_A_!II_E('-1,-2,-_s_u_LF_A_T_E -{c-,s-, ---------+··· I ·YES Pages .. ______ _ 1121/22/96 12: 13 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.139 P008 Chemical Inventory April 22,'96 011\MINODECANC PS 1G YES NO .......... -YES --DIAMINOOIPHENYI. SULFONE PS 25G YES ·-· ····-OIAMINODIPHENYLAMINE SULFATE, TECH. PS 100G YES NO · cs·---·-·-· . . DIAMINOfLUORENE-2. 7 1 GM YES ······-·--· 26G ,.,. __ ·---·····-............... OIAMINOOCTANE PS YES NO OIAMINOPROf'ANl:· 1.3 FC-1 100 .. ML ... YES OIAMINOPtJR!NF, PS 1G ..... 011\MINOPURINE 2.'·DEOXY·RIBOSIOI: FRO 5MG ................. ·-......... - OIAZASICYCLO-NONENI: cs J25G YES NO YES .. ···-----·--............. 01A2ASICYCL0(1.8l(S.4.0) UNDEC-7-ENE(l .S-SJ l .... ........ .. OIAZJ:PAM ' YES ---OIA-'OXIOE PS 1G YES NO PS 25MG YES .... NO .. ' OIBEKACIN I OiBENZYL DIISOPROPYL?HOSPHORM!OITE cs 5ML f 018ROM0(1.3)-2-Pf!Of'ANOL cs SGM YES f .. 1 DIBROMOETHANE[ 1,2) cs 5GM YES I ' cs 100GM YES ; OIBROMOHeXANE(l,6) I cs 100GM YES \ OIBUTYLTIN OXIDE DIC!·H.OROACETIC ACID FC2 100GM YES .... _ ·---·---····· ..... . ~ .... ······--· O!CHLOROACETIC ANHYCRIOF. FC2 t10GM YES FC2 \500 GM ........ YES ..... ··-----.. DICHLOROI\Cl:TYL Cl!LOnlDE: OJCHLOROETIIANOL·2,:! cs [10GM YES .. [ YES DIC! ILOrtOl'L!JORESC51N DIC! !LOROMGTHAN!i YFC ~6L YES YES DICHLOROMETiiANE. ANHYDROUS FC-1 1 LT YES .. . . -. -·-.. _, _,.,,,, ___ ,,,,,, .. _,, ·----..... ,---- OiCHLOROTRIPHENYLl'HOSPHOKANI:, 9S% cs 25GM YES ' ··-·-YES NO ' OlCYCLOHE){LCARBOO'lMtOE, 1,3-PS 100G ' ' .... -----·--········----·--i D!CYCL OHEXYLCAR80D11MIDE(1,3) cs 100GM YES i DIC.Tl IANOLAMINE j:i§" .. -----· -.. S00ML YES NO I I DiETl1YL AMINOMALONATE HYDROCHLORlDC cs 25GM YES ! i DiETHYL /\ZODICARl30XYLA Ti: EPR 25MG YES YES ' I '"-····-...... ...... ------0,0 .. ,, OOHO ___ DIE'fHYL 8HOMOETHYLPHOSHONATE(2). 97% cs 5GM YES ···---· 1 .......... ·-· --····-·· DIETHYL BROMOETH'YLPHOSPHONATE(2l cs j5GM ----··-·-.. DIETHYL CHLOROME'fHYLPHOSPHONATE cs !1 ML Yl::S ............... DIETHYL CHLOROMETHYLPHOSPHONATE, 97% cs ;1 ML _,.,_,_ l1 LT ·f PIF.THYL ETHER, ANHYDROUS FC1 l1GM .. ,, ___ DIETHYLIN,N ),1,S,DIHYDR0-2,4,3-8EN7.0DIOXAPI-IOPHEPIN-3-AMINE cs DIETHYLJ\MINE cs 100 ML i . . . . . ... ! Dll'THYI_AMINOPYfilOrNE cs 5G OICTI lYLAMlNOSULFUR TRIFLUORIDE EPR ............... . 5.GM . ' ....... ... ,,. ______ , ___ ...... ,_,_H __ DIETHYLENETRI/\M!NE cs 1 L YES ------···-·-~---··· ..... DIETHYLPHOSPHORAMIOOUS OICHLORIDE, 97% cs 5GM YES DIHYOR0-4,5-DIOXO-H-PYRROL0(2,3-)QUINOL!NE-2, 7,9-TCA PRD 10MG DIHYOf!0(3,1)-2H-PYRAN cs 100ML YES ....... .. OIHYOROSTREPTOMYCIN SULFATE PRD 5G YES NO l100 GM .. , .... YES -······--· -· DIHYOROXY(4,6)-MERCAPTOPYRIMIO!NE(2J cs _,,,. OIHYOf\OXY A Cc TONI: PHOSf'HA'I c CO2 100MG YES NO -·-· .. ...... --·--T>II-IYT>ROXYBENZYLAr-/lNE (3-4-)I-IYDR08ROMIOE cs 1 GM YES I . ----t-·No __ ,..,,_ ... OIHYOROXYNAPMTI !ALENE cs 5G YES Page? 112!/22/96 12: 13 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.139 P009 Chemical Inventory April 22, '96 1-0_1:_so_s_UTY_LA_LU_'M_I_Nu_M_H_;_YD;...R_ro_E ___________ -1,.:.F...:C:..1.:....._.. 1100 GM _Y_E_S __ ~ .. o_u_so_P_R_OP_Y_L_A_zo_o_1_cA_R_a_ox_Y_LA_Te ___________ 1-c:..s,:__ __ ----l-...;.1..:;.:.oo GM YES --+ __ Y_E_S_ .. -· 1-0_11_so_r_n_oP_Y_L_o_.r_A_RT_R_A_T_E ____________ __,i_C_D_3.:.... __ ~1~0_G:..M_;_ YES 1 1-;-;;;-~-:-:o-::-~-i~-:-;-:-~~-l~M-~-~-:TI-L-LE-D------------1~~~ ... --l-1-~-t-:-~-.::~~_,_;'~-~· .. -=-~-y--~--s_; ____ ... +40 ·---·. ,_0_11_so_P_R_OP_Y_L_s·1_ri_Y_LA_w._.rN_e _____________ -1.FC 11 L ..... 1 __ Y_E_S __ DIISOPROPYLt'HOSl'HORAMIOO\)S O!CHI.ORIQE EPR '5GM YES '"o-,rv-1e-T-HY_t._s_v_LF_o_x_10-e-. o_M_s_o-------------iPS 500ML .•• _..._ __ Y_E_S_ -· NO :o:,rv:,e=T=HY=L=(2.=2=J·=l'=RO=P:A:Nl!=O=!A:M:IN:E:(1:,3:l::::::::===========~CD3 50 .GM .. ·~-.... ~Y==E=S===:---.... DIMETHYL(2,2)·1'ROPANECIAM!NE11,3) OIHYtlROCHLORIDE. 98% CD3 5GM YES ------------------'-----4 . " ·----->-....... OIMETHYLAMINO!'YRIC!NE(4•) cs 25 GM YES 1-0-,M-e-1'-HY-L-eT_H_A_N_o_LA-M-,N-1:-<N-.N}-, 9_9_% __________ '""Fc1 sooML · ....... 1--_Y_E_S __ 1-.. ,-.n-,M-E-T-HY_L_E.-(H_A_N_OLA_M_IN_!:_, -RE-c-,s-T-ILLE_C_O _________ ~cs 1 do ML ....... ..!---Y-E_S_--1. ... 1------------------------l--·. .. -----+---:------l--~ OIMF.THYLFORMAMIOI: (CMF) FC2 28L YES NO 1-0-,M-~-TH-Y-I.-FO_R_M_A_M;...ID_;_E . .:..A_N....;HY_D_R_OU_S __________ .j...F'~c=-=----!:i 1=-::.:L:..T __ •• YES YES t-O-IM_E_T-HY_IJ_I_YO_R_O_Q_U_IN_O_N_F.(-:7,,-3)-------------i cs. ·-· .. 5GM YES,. .. . l-(l-lM_E_T-HY_L_PH_E_N_Y_LS-ILA_N_E.-9-8_+_% ___________ _.CD3 5GM YES ..... . i---------'---------------1i....:....:.;_;_----1-_;__;__;__;_ ___ i....:....;. __ ~--- OIMETHYI.PYRAZOLE CAR80XOAMIOINE MTRATE CS 25G 1-----------------------------' DIMETHYLSUCCINIC ACID PS 5G ... ----------------------+--·· DIOX/\NE FC 1 L 1------------------------1 YES . . ·----·...,....,,=--+---,--+-----l YES NO YES -YES-..... ·-·- ... ---1------+---1 OIOXOLANF. PR D/FR D 1MG/1G 1-o-,P-H-EN_Y_L-.C-HL_C_R_O_PH_O_S_PH-A-.f-l:,-99------------lcs -· ..•• 25 GM -··-1--·-v-E-S--:-/------1---~ i------------'-------------1 .... OIPHENYLAMINE YES i OIPHFNYLMETHYLSl:..ANE cs 5 GM i YES ... T 1-D-IP-IIC_N_Y_LM_E_Tl-l_Yl_S_ILA-NE_;_,-9-a~-~-------------lcs ... 5GM ·-···-··-·· i ·-----:---·-·--·-....... _. 1------------------------1 ..... -···-+-----+----! DIPICR/ITE PR ,25MG DIPYRIDAMOLE FR o ;2DG YES ----------------------1--------'-----~-----·-····· NO OISIAlOGAN<lLtOS!:J!: FR D !4MG 1-o-,s-U-LfU-· -RA_M _________________ ""ps [1G.. •. -............... ·---··--+-----..;,---1 D!THIO NITROBENZO!C ACID C_D_2_-_··_·· _·_· -..;[_5._G_· ___ -+ __ Y_E_S_-+---·--··· ... .!. .... .,_ .. 1-0-!T-HI-O-TH_R_EI-TO-L---------------~EPR 1 G YES f .. o_m_ER_1-_,., ________________ ~ cs 10LBS YES .. ·: ........... ~-C2.. ... .J -· ·-... D:Jl.Bl:CCO'S PHOSPHATE SUFFERED SALIN!: YES l ove REAaem IPRor1eN ASSAYJ PR 450uL · ... .. ... ·····-· _ ...... _ .. ! ........... .. 1-0-Y-NO-R-... -H-IN_A_(_l·-10_) ______________ .....JFFf'~D---!--,.1M,...,,..,G:-----+------+----+l---i OYNORPHfN A (1-13) FR D 1MG YES / -----------------------------1----·-··-··---,,---+----+-----l .. o_Y_NO_fi_t'_H_tN_A_(_I·_7_) ----------------iFR D 1MG -··· ....... _ r OYNORPHIN A (1-8) FR D 1MG ... OYNOrlPHIN A (1-9} FR D 1MG :D=Y=NCJ=R=P=H=IN=/\=(=/\=RG=e=··=1·=13=l=========================~~F..:.R..:...::.D __ ----l-_;_1M~G;__ __ -4--____ . ____ .+.-.... · ::::~:~~·:J~ . DYNOAPHIN A (ARG8, 1-13) FR D 1MG l 1-0-Y-NO_R_P-Hl_N_A...;.F_RA_G_M;_E_NT_;... ______________ .....,1 PR D/FR D 1MG/1 MG i 1----------------------~·-...... ·-···-···-.............. _ ... ,. EOETATE O!SOOJIUM O!HYORATE cs 500G YES NO ; t---'-------------------1-------+-----I------+--;__ _ _;._ .. _._ ENCAP$1N HPl;I PS 40G YES i '"e-P,-N-EP_Y_KI_N_E ___________________________ ••• _ ··-·· ..... YEs······-'-····--·-· ....... • 1----------------------1--E f WT ll RO· 9 17..HYDROXY·3-NONYL)AOENINE HYOROCHLORIO~ PR ESTERASE FROM POrlCINE: LIVl:R. CRl)O~ EPF ETHANEOITMIOL C$ Page 8 ......... _ ..... -.. 200MG '.20,000UN •. l100G YES v·Es ... · YES NO NO H:l/22/96 12: 13 CYPROS PHARMACEUTICAL CORP 7 619 438 0046 N0.139 P010 Chemical Inventory April 22,'96 ::::::·IIOL. E7% FC2 1 OOML. _ ·-+----~~~ l ·-==~ _ .. 1-~-T:-':--:-:-~-,:-~-NE_H_Y_o_A_oc_H_L_o_F1m_E_._ss_+_·_,,, ________ --1c~Rso~ .. .. 5 :~~ 0 GMG. ·M· •·· :· _____ ,!-Y~E~sss . . ~ 1 __ - ::.THY:. (Sl+l·LACT A'" ETHYt. ACETATE FC 4L ~YES "l'RS••· _L __ _ 1-E-TH_Y_L_A-LC-.O-H_O_L·---95_')(,_(R-EA_G_E-NT_G_RA_O_E}____________ .• • • YES •.. NO ~ -~ ----ETIIYLBROMOAC!:TATE FC2 :500ML. .. YES -~--_1· .. ·- ETHYL CHLOROMHHYL(Sl·FURANCAA80XYl.ATE(2), 97% cs . ~ 1 YES :ET=H=:Y:L c:v:A:No:A:c:ET:ATE=========================~YFCFC2~_ ... ---=i~o~OLG . . -·y····E· s-N .. 0... _ .... l:T'-!YL E,HF.R ._, I-ET_, H_Y_L_TR_I_FL_u_o_Ro_A_. c_E_TA_r_e ____________ ~_;CF_;_cs· ·2 .. 26_s~_GM_ M ..... _ l .. YES ··--··.-... .... ... --- ETHYl.-3) TRlFLUOROTHIOACETATE 1 ,..e_TH_v_L_A_Mt_N_ •• _:i_.o_M_s_o_L_u·_no_N_I_N_TE_.TR_A_HY_o_R_oi=_u_R_AN _____ -'~PR __ . 100fv'.I_L __ .. YE~···----·· __ ETHYLENE Gl,YCOL PS 1 L ' YES NO I-E-TH_Y_L-EN_E'_G_I._YC-.O-L_D_IM_i:_T_HY_L_E_T_HE_R __________ ~FC1 -·-500 ML---YES . ,.. ,___ __ .... _ -·-ETHYi.ENE GLYCOL TETRAACET(C ACID PS ... 25G ·-'-·· ---..1, . . , 1-C-TH_Y_L-EN_E_O_IA_M_IN_E_A_B_SO_L_UTE ____________ --J...;F_;C...;1 ___ . 350 ML . . ... YES .. ____ ·_-_t-··. ETHYI.F.NFDIAM!NETERA/\CETIC ACID PS 500G I ---·---~-.. ~ .. - tTIIYL!'ROPYL CAHSODIIMIO!i CO2 1 OG E;JROP!UM TRIS(3(TRIFLUOROMETHYLHYOROXY-METI!YLENE)( + )CAMPHOR CS -j1GM ____ J. --·--·-Fltlf!INOGEN, HUMAN TYPE Ill FROM HUMAN PLASMA ' ···---· YES I ----~r--· l'LUNARAZINE FR D 1 G YES NO ·-- 1-FL-UO-R-FS-C-AM-IN_E _____________ "'_E_P_F ____ 100.MG -YE~. __ i __ _ Fm(l~·ARG(Mlr)-OH coi ~-. YES" NO 1· : .. ,:»c:c-=A=Ru=·(M=tl'.=)-=R=ES=IN==========================::ccoD21 .. ··-55.GG_ .. .. I ... YYEE. ss . .NNOO -. ;i ··-- FMOC·CYS("fSU)-RESIN ::~~~~-OH ~~~ ~;~ .~~ j ~~---1 -Ug f~:_ - :1-:M=_M:=_:=_:~=_-~=_y~=-RE:_Sl:_N:_ -==--==--==--==--==--==--==--==--==--==--==--==--==-...,j=~gc~DDD~221~--·:· 2~5~GG . •.• •. . .• yy~~E-· ~s--_ ... '··-NNN 000 .. =f· ·-. fMOC·L·ASP(OT!llJ)·OH FMOC-L-CYS(TRTJ CO2 25G ! YES NO FMOC U"lLN(TRTI CO2 i!25G . . "--VES . NO -· · - :r:M:oc=·=L-a:.-L:u-:ro=r:su:1:::::::::::::::::::::=====~CCDP.~2 -. _225 5GG··--~ 1-YYE~SS . NNOO ---~ FMOC·L·l"IS(TRTI 1-:-:-~:-.:L-!~~-~[!-~----------------1--g-g-~ .. .. ,~~~ ... . ~~ ~~~ --~g ... --- t--F_M_o_c._1,._LV_S_lrl_OC-'J ________________ ---4~02 ··. ;2~· . __ :~ YES-· . N?-__ _ I-F_M_oc_.·L-·M_E_T _________________ co_? ___ 125G ___ Y~S .. NO __ ,_ __ _ FMOC,:·L-ORN(BOC) FMOC-L•PHI! FMOC·L-Pl"!O CO2 25G YES NO I-F_M_O_C--L--SE_R_(l_tl_U)------------------iCD2 ____ 25G ___ ' ·YES°· No" .. l-1'_M_o_c-_L-TY_R_<T_B\_J1 _______________ .,_C_D2 ---~G-_ -.. ____ ,_ __ -YES .. -.L.~o-L,_, __ 1-F_M_oc:_.-L_-v_A_:. _______________ --1CD2 ______ 25G ··---YES ··l NO . ! __ Fmoc-LYS{BOC)-OH CD2 i25G YES NO ,. t-------------~------1-c-o-2.. . 5G . . '--YES ·, .. -No· ··--l'MOC-LYS(80C),P·ALKOXY8EN2YL ALCOMOL RESIN Pages 10/22/96 12:13 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 ND.139 P011 Chemical Inventory April 22.'96 r.MoC-LYS(RCCl-Fll:StN CD1 5G ___ Y~S =t NO_j __ ,_F_ni_cc_·_Lv_s_,s_o_c_)·R_E_s_1N _______________ ~c_o;;...:..2.. . ....:~ -· --~ES • .. Nq __ l ··- 1-"-M_o_c_-R_ss_,_N_IR_1N_c_1 ________________ .... c_o_1 __ 15G___ ...._ YE~--NO .. I·-· FMOC-THR(TBU) CDZ 125G . YES NO I :FM=· o:c:-T:v:n-=Re=s:1N:' ============================~~C1 Q~D0.:..1GM _::=f 5EGPR~-.J= ... YYEESS. l ~0. . [ -~-::- t-F_O_R_M_AM_10_,111_e_su_u_F1_N_1c_A_c_10_._g_s_'* ___________ 4CS ·--1,1-L ··-/ y· Es· .. _ +- l'ORMIC ACID t-F_R_uc_r_o_s_Ec_-o..;.)_1_P_H_os_P_H_A_TE_s0_0_1u_M ___________ 1-E....:P_R.;_ . hoo MG . ~-YE~-=1 . -~-.:._~ 1-F_R_~_-_,o_s_~_o_>s_._~_o_s_P_M_,_~_0_1s_o_o_ru_M_A_M_o_n_ffl_o_u_s ______ ~-----l·--· -~Y~. FRUCTOSE·6-PHOSPHA1!: PR . 25G . ...... ----------------------1---FRUCTOSE· O 1,6-0IPHOS?HATE FROM RABBIT LIVER ·--1 ---· 1-~-::-J:-.~-:A-s:-~~--t-:-ya~-:-1:-:c-y:-.:-~-A~-~-·s_o_o_1u_M_s_A_Lr _________ ~ EFEC:R 2 F -. . r 1 ::00GO:GM . -~ -y· ES:=· FURfURYt AMINE "ii YES .. ·-· ... .. YES -· ·-· - .. YES _..__ --· - 1-G_A_LA_c_r_o_s_M_r..1_N_E _____________ .....:. __ ~P_S:_ . · j500MG · ·-~-~-__ .._-:-~~ .. GAi ACTOSAMINE 1-lYDROCHLORlDE l YES } ..... G_A_L/\_N_IN-(1--1-61---------------+Fl:_R~_D -i:GV(AL~_-::-. _.:_-· _;_~---· --~ ~ALLAMINll TRIETHJOOIDE , ,-~-!-;-~~-}-,I-:~-~.-:,-I~-~~-;-:;-: __ T ______________ ""'~: ~ · .•• !~o! =~~i~: .J~ 1~~ 1-c;_u_c_1o_Y_L_4·_M_e_,H_o_x_v_P_Hi::_·N_v_L_ET.,.H_e_11 __________ --1EPF -~~ GM . --· ·-· ___ ~- .,.a_Lu_•c_o_s_AM_1_N_1: ________________ ,...PS ~ / _ 1- G-LU_c_o_sE_c_o_i._on-RE_A_G_EN_T ____________ -lPR·= ---· .=: ... --~YE~ss_·~· .· _.: .! _·-. GLUCOSE OXIDASI: 1YPS II FROM ASP~l'!GILLUS NIGllR __ OCVCOSEMHO""""' =7!:G -I 1--:-~u-u~-:-:-::-;-_:-:-:-::-:-:-~-:-:~-5H ... 0v0_~-::-G_E_N_A_se _________ ~.p~..:..~R-· -.. 14 2 2M~G: .. · ._..:.J: ___ ~ES.. · I--~.-_·. __ ] --·_ .. GLucose-a-P11osP1-1ATs MON0s001uM --· f I ,_0_1._uc_u_R_o_N_1c_fA_-o_._1A_c_10_1:_1_-P_H_o_sP_H_A_T_E_TR_1P_o_1_1:s_s_1u_M _____ --4~p _ 15 M~ ·---. ·-·· ... L.. ___ ')·-: __ GLYBl=NCI.AMIDE I YES ~ t-G_L_vc_i=_.RA_LD_E_H_Yo_e_1c_L.;..l_3-_P_HO..;.S..;.P_H_AT_e __________ --:1-. ~7" -~-_ _:_~ _YYEESs· . • :~-... _--·- GLYCERIN :~:::~:~ 3-PHOSPHAfE OEHYOROGENASE . ~;000 lJ·-·_ ~:tJ,. . ~~ .. 1-~~- GLYC!DOL ~ GM-___ -·__ __Y_Es .-1.. -_-_·· r-· GLYCIOYL 4-IV-ETHOXYPHENYI. ETHER, 99% --YY!=ESS _J_, ·--t·-· GLYCIDYL(fllMETIIYLAMMONIUM CHLORIDE(+\·) EPF 100 ML ·-· I t-G-LY_C_"IN_E _________ ._;........., ______ -lcs--_.___ ··-· -· yE·s· I ,._,_ . . ·- GLYCINE METHYL F.STER HCI cs ·-f~~~G · ·-·· YES r-·· '"G_L_v-cc_L_1c_A_c_,-o------------------i--···-r-· -· · YES --· ·-· I -- aLvcoLoN1,mLc,ti5WT <y.soLur10N 1N wATF.R cs --·zsGM .. YES--~·--r·· 1-G-l.Y_O_X_YL-JC_A_C_!O-FR-EE_A_c_1o_M_O_N_O_H_Yo_R_A_TE_· -------~P-R_ 0 ·-. -____ 1 · 1 __ 5 M-_G _·-___ ·w~---· __ :-l-:·- GOLESTA7.INC j :ioua~RonN FR ·o ·-SMG · ·-· ·-· ·l-· ---i--------------------1-PS ·-·· 100G ---_ _!'ES·-· NO_ --· GUAN101Nc Ac1IT1c Ac1c _._ -.. .. __ YES . j . -~o __ __ GUANIOINE HCI PS 1 00G YES i NO ··--PS PR -- cs ·-· ·-·· Page 10 10/22/96 12:13 CYPRDS PHARMACEUTICAL CORP~ 619 438 0046 NO.139 P012 Chemical Inventory April 22,'96 ,_G_u_A_N1_D1_N_os_e_N_.2:0_1_c<_4·._l _Ac_1o_HY_D_R_o_cH_!._o_m_o_e ________ EPR __ 1 G_M___ . YYEESs· j ··-· GUANINE HYOROCHl,ORIDE CELI. CUl,TURE Tl:STED • I-G_U_A-NO_S_IN_E_5_'.-0(-3,-TI-11-0T_R_lf'_H_O_SP_H_A-TE_) _Tl:_T_RA_L_ITl-l_lU-M-----~----· --· . -,-. YES ··1--.. GUANos1Ne s·-rR1PHosPHA1e s001uM .. ____ --· ··-r .. YES·-,---·-1 ··· J-,H-BT_U ________________ .,.PPRR,_D_ 45GOOML ·t-··... -=t=~. 't! . HEMOGI.OBIN ·- HEP,AFLUOllOBUl)'FilC ACID cs--100 GM .__YES ,--.. 1-H-:-PT..,.A-r-L_U_R_OB_U_T_IR.;,,;IC..;.A_C_ID--------------ICS·--·· ~L . ·--·· _j-"· ""~-:~-T-:-~~-:-~LF-c;-~~-~-~-,:c-!:.1_0 ____ ..,...... ________ -1-F~-c~22· _-=_251 ~G· oM~l\if .. =-'-···. -YYY~E~S:=-+ -N~ -[ ~- HEPTYLoxYa~NzoYL CHLORIDE -. I I ·· t-H-EX_A_A_M_M_IN_E_C_Ol:J_A_L_T_(ll_l)_C-Hl._O_H_IO_E __________ ..,.PS ··--·· 10G--0 YES ·--NO . -- I-H_cx_A_A_M_M_1N_E_N_1c_KE_L,...;(...;.ll)_C_HL_O_R_1o_E __________ -i-:.CP~Ss_ .. ,r 25-0~-0G-MG._:--· YYEESS __ ··----XE~1· -·-- HEXAAZACYCLOOCTAOECANE-1.4,7, 10, 13, 16 ..,H_EX_A_c_Y_CL_E_N_TI'l_1s_u_LF_A_n:. _____________ ..lc,_D_3_·--· 1G~ --~~E~--· ~o __ ·r-·· . HGX/\CYCLEN TRISULFATE cs 1 G YES NO · 1-H_EX_A_M_e_TH-v-1.--H-crx_A_c_v_cL_o_o_c_rA_o_e_cA_N_=----------'-cp-Rs •. D _ _=--1 1 - 0 00GMMG-· . ··Yy!=Ess... ..i--~o" · .L-. -... HEXAMETHYl,01S!LANE t- 1-H-EX_A_M_E_T_HY_L_SN_E_TE_T_RA_A_M_I_NF._. ------------11-F's =:· 5ooG___ .. ----ves ·1 ~_Es · __ _ 1-H_EX_A_M_E_T_HY_L_PH_o_s_PH_O_R_A_M_ID_F. ___________ -+-cs _ 100 GM _ .:· YES ___ '(ES ·t-· HEXAMETHYI.P\.IOSl'HOAAMIO£. 99'!(, cs 1 OOGM 1-H-EX_A_rv_t!:_TH_Y_LP_H_O_SPH-O-RO_U_S_Tll_!_AM_l_OE-----------IEPRP_R -~· 255MGi. . • • .L-1 . YYEESS --~ -.. -N-· o"" ·,··· HEXANE-ot,\MINE I 1-:-::-:-:-:-:u-1.F_O_N_IC-AC-!O-SO_O_IU_M_S_A_L_T _________ --l~F_C __ : .. ~--~ --~·-·! ~:~ .. _N·o -· 1 ----= t-l!_lG_H_V_Ac_u_u_M_G_,R_EA_s_e _____________ -lcs .. _, TU~E ~ · I· -X_ES ··-~NO 1~- ~ ~ ~ ~ f ~::::::~,::.:OLACE1'0NEIDL> PS--.. -.. -~G. ·+·· . YEs·7--· -~-:-t-, .. _ :H=O=M:o .... c-v:s:TI:N=E=T.;.H-!..;.O-LA~:c:F.T:O:N=E~(u::::::::::::::::::::::~PPS_R __ ·--22550G~G . . ..:·-, __ r·-·· ,._: ... ·- 1-tYBRIMICIN t 1-H-vo"'"n_A_N-AL_S_T_A_N_OA_RO_s_o_o_1u_M_T_A_RT_M_re--------..--1,.;__-__ ,__.. ·--·YES --· ··-.. 1-l-t-Y-OR_A_Z_IN_E_M_O_N_OH_Y_D_R_AT_E. _____________ -11--.. ·---. ··-·· . YES YES . -- HYORAZ!NE SULFATE ·-...... ·--· . YES YES --· f-H-Y_D_llAZ-,N-0-!M-ID-AZ_O_L_IN_E_H_Br-------------1--c-s-·-"5l3 ··-· YES. . NO' _ .. ,_. IIYORAZIN0-21:?-IMlDAZOLINE HYOl"IOBROMIDE FCi ·-1L ·-·· YES. . --·· , -.... 1-H_Y_D_HO_S_R_OM_!_C_A_C_lO _______________ ._... ·-· ·-· .YES j----. +-· ... :_:_~:-~-~-:~_·:_~_::_:_:_:~_. 1_N_s_Llll ______________ ~ = !iioML. -=~~;.~ ~~ : 7 _:: 1-H_v_o_Ro_c._e_N_s_F10_1v1_,o_e_. _:io_w_r_%_s_o_L._1N_l\c_·1:_·r_1c_A_c_10 ______ ,_,i=C2 ·--· _1 OOML ... Y~S /--·-· 1 __ _ HYDROGEN CHLORiOE YES 1-~-:-::-:-:-~~-;-e;-;_x_1o_e._3_0;;. _____________ ~-:/PS · -rs~~~L/10_~-~-_ ~:~ ·t f ~ · t-· ····- HYDR0s1Ne MONOHYDMTE,98% FC2--· I' 00 gin -~. --f YES · · .. , __ :M:Y:011:0:x:vR:E:Nz:o:1c:A:c:,o:::::::::::::::::::::::::::+-cp. ·. 5 s .:-.-. S 25 0G~M _ .·-yy··_EESS .. Tf . No·· .. ~j_ .. ___ _ HYOl'lOXYBENZOTRIAZOl,E 1-H-vo_11_0-xv_s_eN_z_o_rn_,A_2_0L-e-------------+-c..,.s-_ -=~ GM_= .· YYEE_s 5 ·· ;· -~_No ___ ·f . __ · HYDROXYMETHYL(5l FURFURI\L, 99% HYDROXYPROPYL CYCLOOEXT!'!AN PR o -1ciML · -··· 1 · YE~;' i ·-·No Page 11 .. 10/22/96 12:14 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.139 P013 Chemical Inventory April 22, '96 HYOROXYQUINOLINE(S) cs 25GM YES 1-H-Y-OR_o_x_Y_su_c_c_1N-IM-,l-'-OE..;._ _____________ ""cs ___ ...... 2_5_G ___ -4, __ v_E_s ··- ,_H_v_o_Ro_x_YTY_R_A_M_IN_e_-3_)H_Y_o_A1_cH_L_O_H1_0_1: ----------1 cs ... :io GM" ....... ·-···-···y--e-s---l----·--......... . HYDROZINI: SULl'AT!: FC2 5 KC3° .... ····----+--N-0-->-·-·-·-· 1-----------------------' HYGR0"1YCIN A PR 50MG ·-· ------+-----1 YES I -----------------------... H_Y_G R_o_:1._1 Y_c ,_N ..;.B _______________ ~P R DIPS 250MG HYPOXANTl-llMi SIGMA GRADE cs 25 GM 1------------------------I'--'-----+'--....:....:.;_;__ ............. . IOOETHANE FC2 100G YES NO 1-IM_I_O_AL._O_L_e ------------------+cs-----100 GM ·····---· YES _.._ -------- YES IMINC(.?). 1 ,JMIDAZOLID!NEACETIC ACID cs 5 GM YES ----------------------'--·-···-·· .. -·--···. -·· ........ . IMIPRAMIN~ HYOROCHlORIOE PS 5G YES t----------------------1-----+--=-------1'-----~ -· INDOU:·3-ACETIC AClD cs 25G YES NO INOSINE S'·TRIPHOSPHATI SODIUM GRAO!i GRADE I YES l ................... -· .................. -.. ,----,'------l----1 INSULIN FROM C30VINE PANCREAS YES ! INUUN,fl'!OM CHICORY ROOT cs 10 GM i YES ----------------------'-------4-------l'-----"··-.. IODINE cs 100G ; YES NO i-----------------------1 ._ .......... ·--···-....... L ... ----+--'---+---,-·-10LJOACerAM1De EPR 25 GM YES ---------------------100 CB ENZ ENE OIACE1'A1i:: PS 100G YES NO 1----------------------1 IODCl)ODECANE-1 cs 25 GM YES l 1-::_:_:_:n_eT_ 1:_:_:_1: _______________ --1EPR ---100 GM. --Y~E~S~---··-~YES_· __ ~.:.~:~·=~· 1oococTADECANc-1 CS 25 GM ... ,o_D_c_s_u_cc_,1N_1_M_:o.;..E._9_5_% _____________ -lcs 5GM i YES ISOPROPYL /\LCHOHOL CS 4L .-! . ··-· ~S. ...... _ . ·-·-· ___ _ 1-J-OH_O_S_P_ID_E_R-TO_X_IN----------------+FR D . 1 MG..... i 1-----------------------'--· ...... KANAMYCIN PS 1 G ! YES NO -----------------------1--·---+------------+--;__-......;, ___ _ KANAMYCIN (S-EPll PG 25MG i ! 1-----------------------''· . . .... ·-··" ........... ---KANAMYCIN A MONOSULfATE PS 250 MG I YES \ NO 1-K-AS_U_G_A_M_YC-IN-HC-,---------------IPR. D/FR D 25G/1 G . -...;....----+!_,_ ···----t----t -----------------------... ... .. .. t-------+------+------l----1 KF.TAMINE HC) PS 500MG ( ·--··-·-· --;·--··--·-·-·~·-· KETANSERIN PR D 1 0MG : :L=·A=S=CO=R=B=IC=A=c:10:6:·P=A=LM==ITA:T:c::::::::::::::::::::::~cs 100 GM J L-TYROSINE, 99 -% cs 1 00GM : ---------------------1------ I-L_Ac_T_1c_Ac_10_,_a_5_+_%_S_O_LU_·1_·1o_ri_1N_W_A_TE_"ft ________ --l ____ -+Y_E;__S _____ .,..... \ .. 1.ACTC-N·TETRAOSE YES i LAlJRL SARCOSINF. PS .. _.,., ......... 500G ! ---------------------.. ' LAURYLSULfATE PS 100G , 1----------------------11----------1-----...--------....... LEUf'cPtrN FR/FR D 5MG/1MG YES l 1-L-EU_P_E_PT-IN_H_E_M_IS_U_LF_A_T_E_Ffi_O_M_M_I_CR_O_S_IA_L_SO_U_R_C_E _____ __,1------+----.. -· ·-. YES . NO LEVPE?TIN HYDROCHLORIDE FROM MICROBIAL SOURCE FP ___ ,,..,_. 5 MG YES 1-L-IP-A-SE_F_R_O_M_P_SE..;,.L.;..D..;,.O..;,.M.;..ON_A.;..S..;,.F..;,.LU.;..O..;.R.;..ES_C...;.E.;.NS.;.. • ..;..;....;,...;,...;;.. ____ ---1 EPF ... 10 MG I.IPASE, TYPE 11, CRUDE, FROM PORCINF. PANCREAS EPR"'"" 100 GM YES 1-L-IP-A-St=-,-TY-P_E_V_1_1,-F-RO_M..;,._CA_N_O_lO_A_C_Y_l.l_ND_R_A_C_EA-'---------1 EPR 25 Gl\t1 -· ·+---Y-E_S _ __. ___ _ 1-------------------------1 _ _,__ ____ -1-------... LIPOPOLYSACCI !ARIDE FROM CSCllrlRICH!I\ PR D 1 00MG YES NO 1 LITHIUM ALUMINUM HYDftroe CD3 • 206G 1 OOG YES ~· --- :L=m=11:uM::A:z1:cc::::::::~======================~1-c,....s,--__ -+2~-~~G;· G .. , ... , ___ v_E_s ____ .. _··_· ·_· _N . -·· .. LITHIUM BOROHYORIDE cs YES UTHIIJM·CHLORIDE cs·..... YES 1-----------------~CD3 5G YES-· UTHIUM MOl\:Ol-lYOAATF. ···--·~--..... ....... -+---i NO ., .. __ _ • Page 12 H:J/22/96 12: 14 CYPRDS PHARMACEUTICAL CORP~ 619 438 0046 N0.139 P014 Chemical Inventory April 22,'96 l-1._1v_1o_o_M_v_c1_N_/\_s_u ___ LF_A_T..;.1: _____________ -JPR ~ ... _____ 3_5~MG ! . YES -~o I ··- LUCIFERASE-LVCIF!:HIN IN GLYCINE BUFFER j YE$ ~~ 1-~-::-:A-::-:-::-·::-~:-~E;...s~-;:-:-~:-:1-nG ____________ ~:FF....:...~R;gD· .. ,~ . ~~ •• :: _:_~.. : .. . ~YS-l.YS-LYS·TRP•LYS•LYS-LYS-OH-GACOH-7H20 5MG ' ' 1-~-v:_:_:_;s_~~_:_ 1 :_:_1L_o_R1_oe-' . ..;.P..:..ow~oe:.;.R::...' ·..;.3;;..2s...;,M_F....;,.s_11 _______ -1~~ D -_ ~~oGM -YES I :. ! ·= ... :_:_-:_·:_::_:~-J=-~~-;-~:_1~_r:_/_N_H_v_oR_o_u_s __________ -1-gE_fFP$_::i2~5~~G~ -r Y:E::S ... ---0'-4.·__ -·~ MALACHITE G,AEEN I-IYOflOCHLORIDI: r MANF.s1uMc11LoR10E PS ·· ,sooG · YES --· No~· MAN<;ANESl!(J!J CHLORIOE ANHYDROUR cs ~OGM ±' -YES . ·--.... 1-M_A_N_N_OS_A_M_IN_E ________________ ,.jPR b==-TI'~ ·----I -· . ~M=C=L/\=M=l=NE:.:99=%=-===============================~-c_·s___ :100_~_ .. ···vEs . YE~ -i . MENAOIONI: : YES . . L __ _ 1-:-.:-::-;-:-:o-u:-TNT_KA_~-:-~3-4-------------..........J ps ____ . 500G . ~----~ES -r·. . ----',· _. ... 1-:-·:~-R:-~-::-A-C-ET_A_T_e---------------+-cg~··s~----3-· •. :1GOGG .. M--i-Y~E~S~.. ,·-· ?6 ; .. := METHANESULFONAMIO: J MCTUANESULFONYL CHLORIOE FC2 1 L YES .... ---. 1-M-E-TH_A_N-'!:-SU_LF_O_N_Y_L_C_HL_O_R_ID-E.-9-9_+_%-----------li--E--P R . 100ML . YES-.... 1 • t-M-1:_rH_O_X_Y_(il-)--( .-,-A-,(m-lft--.-UO_R_O_M_l;T_H_Y_Ll_• P-H-EN_Y_L-AC_E_TI_C_A_C-,o----ics ~56'MG ·--~-YES ·-· .. METHOXY(S),(·)·A-(m!l=LUoROMETHYL)·PHENYL/\CETIC ACID YqF~C 41 OOOLM~--=---· YYEESS -N··o··.. -= METI-IANQL, ACS GRl\01: METHOXY(3)·PROPANEOIOL(1,2),98% cs . 5GM____ YES ___ .,_____ +- _Ml:TI IOXY'ETHOXYMETHYL CHLOl'1l0E ••• -. ---.. YES ! ---· :M=1::=1 H:o:xv:P:Ro:P:EN:E:-2:=========================~-+-~E-?~J{ ... · s50GGM~: ___ -__ .. YE~. ·· .L ... __ ··-: 1 _ ... -- METHYL 3·AMIN0-5,!l-OICHLOR0·2·PYRJ\ZINE-CAfl60XYLATE ·-I METHYL ALCOHOL. ANl-lYOl'10US CABINET 2L \ YES l t-M-ET-H--YL_O_IS_U_t.F'I_O_l! _____________ ~FFCci··-:-28· 5L0GM ··-·.·:-+··· YYEESS -r~NO-· ... J_ .. -- METHYL ETMYL KETONI: I ± METHYL"'-'"""'"' PR D. 5G . -· 1 -YES~-NO~. -_ METHYL HYORAZINOCA1'1BOXYLA TE cs 1 00G YES 1 1-::=-:=-~:=-:=-:=-::=_v;=_,:=-~=-~o=-\~=;...::=-:=-:=_u:_LF=_o=_NA=_,= __ ·e,='-,;s=-s:-'%:_ -==--==--==--==--==--==--:=::~-+,.;~;:..,~;:..,R __ ~==--_· · !i~~-~-ii~-,-\~ F 1 :-_-- MF.THYL suLFoxioe CS 1 L t YES _L Cs ··-t-10G·_ M .. . .. YES ·-·-------1 ·-METHYL 1nlFLUORCMITI-IANESULFONATE t- 1-1'/.-.E-T-HY-l.-l:!-l T-I-I-IO_P_S_EU_O_O_U_RE_A_(2_) _SU-L-FA_T_E_, 9-8-%-------i cs: _ ~-M--_r§S . -·. --·-· I ---· =:=~=TH=H:=~=.:=:=:;=:=;=,~=:=:=,:=Y=L)=BC:N:z:oA=-r=e===================~~;:-_-_-:_-:_-=_· ~~o~m ... -· i.. ---~~.=____ ·t~~--- MHHYJ •. eROMOMITHYL!41 B~NZOATE, 98% CS SGM +-YES · t-~-,:-::-1:-~-~-:-:1~-:-:A-;Lo_E:-·:-T-F -------------1-!P-pS:_R_·--~. -~-2r5~0G::[ _-: J ·: ~r~--N(}_+ - METHY:.ENf ACRYLIMIOE I +- Page 13 10/22/96 12:14 CYPRDS PHARMACEUTICAL CORP 7 619 438 0046 ND.139 P015 Chemical Inventory April 22, '96 ME.Tl1YLENE CHLO HIDE FC ·W 4l YES YES ; i-M-cr-,-"-L-~-e-~-A-M-~-N-e--------------~P~s---~~~G ~~-v=e=s vEs~--,----_ MCTHYLISOURA PS j25G ! YES NO .,.M_F._n;--y-L-,s-ou_R_E_/\(_0_) H-Y-0-RO_G_E_N_S_U_LF_A_Te-. -99_% _______ ...,.cs 25GM --:---Y-E-S ·-... t-M-E-.H-Y_U'_R_O_P_EN_E_f2-, ----------------+FC2 100.GM ··-t---,-Y.,..,Eu· -·---- METHYLTl'll!'HENYLPHOSPHONIUM BROMIDE CD3 25 GM "·-t--,--Y~ES ' ! ·- :::~:::e~:~:~A:N::::~EV:o::A:3::~:~:::R:l::::T::~:l'R:A:CT:::::::::::::::::::~~~_;_~:~F-·_ 15;~0L-oo-G~---. _-,--. ··_··.. .... ·--·· ··--~~~---.. .. . -!! ~~ • MOL£CU!..AR SIEVE 4A, ACTIVATl:'D ~ MOLr:CuLAR sieves, 3A. BEADS. 4-a Mt:SH CS i 1 KG YY!=ESS ... .•.. • . ·--1-M-O-LE_c_1,-LA_il_s_1EV---ES-.-'1-A,-8-E-AD_S_,_4-_8_~-E-SH ________ _,.cs ' 1 KG •... .,.M_O_N_OS_I_/\L_O_G_A_NG_L_IO_S_ID_E _____________ --iFR O 2MG -·--·--1------------------------i---·----·· MORIN HYDRATE cs 10 GM YES t-M-,O-R-fH_O_LI_N_O_E_TH_A_N_E_S_UL_o_N_rc_A_c_ro-----------+=P~S ·1 OOG -····- MYELIN l:!AS!C PROTEIN FRAGMENT 4.14 EPF fMG". ----------------------li-----M YELIN BASIC l'flOTEIN FROM BOVINE BRAIN MYA!STIC ANHYDRIDE MYHISTOYL CHLORlPf ,. FC2°:· _j10GM F·c2 1100 ML EPR .. j25M~ ·- Y_E_S _ _,_., .. YES YES ··yes ·-· ±-- N,0-81S(TRIMETHYLSILYLJACETAM!Oc ] " ·-··-·-·· NG-$F.N7()YLAOEN1NE EPR 5GM .. " ,._____ ·---...... ~~~ y~ N/\OH PR/FR 1 G/foOMG .. .. ----··· ··- t-:-:-~=-X-0-NE-· -MY_D_R_O_CH_L_O_fll-OE------------~f~.---~-212GOMG' ... · -e--::~--·-_ _ ___ :: . I -~_: · NE/\MIN= PR D . r Nl::OMYCIN SULFATF. EPR .. 25 GM YES NO / 1-:-:;-~-1:-~-::-:-~-,i-:L·::_TF._._T_Rl_llY_O_AA_T_l: _________ --4~pp:Rs··D··~-!1~~M:· G~~--. ·-tl~y~EE:.si ---~N-·~og -·l ~ -~ NEUAOTENSIN i'RAGMENT NEUH!AL RED PURIFIED • ' • YES --. J-N-IC_O_TI_N_AM_I_D_F._AD_E_N_IN_E _____________ --!FR ... '300MG '. -. ··-·--. : ··- NICOTINOYL CHLORIDE HYOROCHI.ORIDE CD3 25 Grvr--_L··. YES --l .. _ . . I . ·--- 1-N-IFE_O_lr-,N-E _______ __,; _________ -l-P-R-ci_·, __ ~--.. . :· YES·· ..f--J!~---+· __ _ NIFENOAPINE PR D 1 G J t 1-NI_NH_v_nR_1N _____________ -t-:::P-=-S _ 1 OG ••.. ·· .• YES_ 1 · · ~~ - 1-N_1N_H_Yo_R_1N _________________ --1cs ·-~? GM ... .. YES . -~S? ··- NINHY0R1N SPRAY REAGEN";' FC 400ML l YES NO I-N_rN_HY_n_R_1N_IET_1_1A_NC_L _____________ -+-F_C__ . 112ML.. .. --YE~ . ~o ... ' .... NITRIC ACID AC 2L +=' YES NO NlTRo aLuE rErRN:ouu:vi GRADE rn ·• · 1 • ---ves · ·--··· · ----------------c·s ··-2sG···M . , ... Y .. ES ····yes·· .. -N1moAceN11PHTHENE-5-~ l-:_::_:_::_:_::_:....;:,_~s-_1_H_10_.1N_c_s_1N_1:: ___________ -IWH~:-~~ 29\0°~0MCMU~FT ·:_~·:i:~ .. ----=-NO: 1' ___ :~= NITROGEN GAS . I 1-N_JT_Ro_o_E_N:.,.• L_,a_u_,o ______________ --lcs 4052CUFT ··--.:·:~--···--· NffROPHF.NOL cs-,_ ---(50G _ .... YE~. I _NO :.:;iv1 OCTAN0!.·1 cs r 1 Lr YES I i-----------------.:-.+FC2 ···110·0· ML ··---·· YES ··.--·--.. -OLEOYL CHLOfllDE · Page 14 10/22/96 12:14 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.139 P016 Chemical Inventory April 22,'96 OME:Gl\•CONOTOZIN GVIA YES ! ORN-ORN-ORN-OH FR c5--·· 100M~---·--·· ·--t .. 1-0-P._N_IT_H_IN-F.(-L)_l_lY_D_R_O_CH_L_O_R_ID_E ______________ -I ··--· --· . YES . --! .. 1-o-r<o-r-1c_A_c_1D;.,_... __ .;....;. ___________ .......J_c_s_· ~ 1 2 10 5 oG·~GM -=~-YYEE 8 s ---==·No .• i= ... OXALIC ACID CS 1-o_xv_T_o_c1_N_A_c1:_r_A"t...;= _________ ......_ ___ -!PCRS·o · l 5 1MGGM~-:--· '(ES.~'--·· NQ__T. · P·TOi.UENESULFONIC ACID MCNOHYORATE l'•TOLU!::Nl:SULFONYL CHLORIO!: CD3 ·--· 100 GM 1-P-N-.. :.A-0-,u-M_H_Y_O_R_OX_I_D_E_O_N_C_A_RB_O_N __________ ---lc-s--·· 10 GM - P/\LLAOIUM ON ACTIVATED CARBON 110%PD) c~· f 10gm. ---;,Es ··-~:fa '"",,-A'-.:.A-D!_U_M_o ... N_A_L_\J_M_IN_A_P_o..;_w;...o.;.e;..;R_,s..;.%.;.;l';...D;;..;.) .;:_:_ _______ -4cs--.-. · 1 o 91'.1 --~ _-__ -_. vEs ____ No rALLADIUM ON BARIUM SULFATE, nsouci:o l5%PD) CS 10 gm YES NO 1-l'-P..-LLA_O_lU_M_O;..N_B_A_R_IU;;..;.M__;:_SU.;..L;;.F;.;.AT_E.;.. _U::;:NR;_;E..:;D;:;U;..CF.;.;..D.;.;....;.. _____ ~i-:c:..;s~ -~Fam . =~-YES'. l-.. N<?~:·· .. :::::~::~::~o:cy=~=;=Hy=L:::: 1 1~::::::========================:::;; _:= ~5~faL ... -·· l .. ~~; .. . --· ' -~~ t-P_A_N_·LA_.s_s_1:_·x_r_RA_c_T_s_<_1-_10_, _____________ ~PR D___ ___ 1 ··-··· ... · NO !·-· PI\F\J\fOHMALDEHYDE PS 1 5KG NO .,.:_;:_:_~_:_:_:o_:_N_s_o<i--------------~:~/P~ D -~~O~. 1-. . . ·y~~ --~NO_·-~+-~- P:.NICILllN smt.PTOMYC1N SOLUTION ~ YES i-:-::-"~-:-~~-1:-·~r:._LE_s:-t-~~-:-.A-M-,N-e------------~PCSS ___ · .. ·· 5 5!'JI __ G_LM. .. _---~-· -~;_~---:_·· .N?_ .. \_._· :. ___ · PENTAF'L\JOROPHENYL Til!FL\JOROACET ATE t-P-1;NT_A_fL_u_R_O_PR_O_P_A_N_o1_c_A_C_10 _______________ --IC~ --· _,50'?___ ·-YE .. S .. -· --·· PENT ANEDIOL(1,S) r1:N1ANesuLFoN1c Ac,o P~f---·soG°· ·---ve:s --No t-' · """Fe-N-TA_N_o_L _______________ -'FCZ:-· sooMC ··---vEs ···· -}.io ··_ · t-i'-EN_1_0_8_A-R8-IT_A_L_S_O_D_!U-M---------------I-·------·· ··'--·vEs ·--· 0 NO -·T l'ENTYLM,O.GN!!SIUM 8ROMIOF' °FC2 . 500ML ··1---YES --NO ·-· 1-P"-~P-ST_A_T_IN_A __ .;...;....;..... ___________ .......J.:..-=.=-·f -= .· YES-~- PERCrlLORIC ACID YES NO \ Pmox10AS1: TYPE V1 FROM HORSERADISH -·-·· YES.· ·--··· I ·-- PEROXIDASE TYP!: xn FROM HORSERADISH ··-·· -.. ·vEs -r-·· · 1-P-HF-N-oL ___ ___;....;.;....;,;.;..~..:.;:;.;:.:..:... ______ ~1-cF. -cs-_ ·150o;s 12 ooMGL __ --1-·· • YYEEss_· --·· . NNo 0 .-, · _ PIIC:NOUAQUEOUS ETIMNOL 'l°1?f\/ rHeNYLAcer,c Ac10 rcss~-I G~M-___ ~ ... __ ·Y··· Es···_,. __ · ,·· ... -. -', ·• PHCNYLALANINe:-L-MIJTHYL ESTER HYDROCHLORIDE _ -· 1 1-P-H-E:II_Y_LB_I_G_UA_N_1_oe ____ _;_ ___ .:;.;;..;..;;;:..;; ______ ~Ps--·-. + 1-P-HE_N_YL-Ll_TH_1 __ uM.......c----------------1EPR. 100 ML · ·-·-vEs ··1·· ·-·· !--P-HC:_N_Y_LM_E-.,-H-YL_S_U_LF_O_N-YL_F_L_UO_R_IO-e----------~E. P.F . _· __ .1~--.. --~~-yy· EESs··1·-t-· .. -=t· --- l'HOSPHATASE ALKALINE: TYPI:' 1-5 ·--_ I 1-l"_H_OS.;.;P_H_A_TA_S..:E;:., ..:AC.;..;1_0..;TY.;.;..PE_1.;.;1 F..:·R.:.:O.:.:M:....:..FC;;.•_:.;.,T.;,;.0~--------1-EPF . --· 1 G __ I --~-~$ ---· . ;:>HOSPHATASc, ALKALINE TYFI: YII-N~A EPF 2 000UN f YES ' 1-:-:-:s-s:-:-:-~~- 5 -:-1:-~~-~-E<;;.;.:-:-~~:'R-------------+-p-~·~-S~G ··-.-·· ·r. . ~:f· .. 1--:-.· ___ : --· 7~ NQ ____ ! - t-F_H_o_sP_H_o_i:_No..::.py:;...;.;.;.Ru;..v_:c;;....;A..:c1..:o·:..TR=1s;.;o;.::o.;;:1u:.;;M,;.,s.:.:A.::L:.:.T.:..:H.:.:YD::.:RA.::.:.:.'f.::.E ____ ~PR··--. ___ . __ YES ... _. _ .. f'HOSPHOGLUCOSE: !SOM!:RASE •• 50000 U _ I .. YES ·-·· ---· ?HOSP!-!OUPASE O TYPE I FROM CA8SAGF. I I YES t-P_H_O-SP-,-,o-M_O_LV-. 8-0-IC_A_C_I_D_H_Y_OR_A_T_E----------~cs . --50GM -1· --YES ···--·· Page 15 10/22/96 12: 15 CYPROS PHARMACEUTICAL CORP 7 619 438 0046 N0.139 P017 Chemical Inventory April 22,'96 FHOSPHORIC ACJO cs . 1500M~ YES t :P:HO=S=P=Ho=n=us==OX:Y:C:HL:O:RIO=ll=· "=R=·R:EA:G:E:NT===============:::~~CC2~2---· 25~· sooooo~GM~ .. -·· . yyy~~ss~ ~:.--NO... . ·-.. ;MOSFHOf!US PENTOXIOE, 98%, ACS RE/\GE:N'f Pl IOSrHCRUS TRICHLORIOE ,_P_!-:'T-,-1,,-LH_Y_o_RA_z_10_e----------------EPF ____ 2s·GM ·· :.· YYEEss· .·.=-~· 1· PHTII/\LICACIO EPi= ____ 100 GM ,_p_1-1_n-,A-L-1c_A_N_H_vo-R-,o-E--------------~cs ·--·· ·25 GM ·· .... YES ·--· ·- ···-.. _ PHTIIAL1M1oe CS .. --·· 50 GM · YES' ·--.. . .. _ ,.Pl_C_n·-,C-A-CI_O _________________ ....i.cs ·---100 GM . YES ·-·· ·- PIPERIOINE FC . --· 1 L. --. -YES . NO. --- ... r_LA_l_'IN_U_M_. -,o-WT_._%_0_N_A_C_T_IV_A_TI:_O_C_A_R_80_N _______ --'cs ~ .. ~_,'(ES ... :_~· 1 . .=· PLATINUM(IV} OXIOI: cs 1GM __l YES ~ I 1-P-LA_TI_N_U_M_DI_A_M_:N_e _o1_c,_-1L_O_Rr_oE:....:.lC_1s_1 _________ ---I ps·· ' --~~206'~:~--!-" . YE(. I . "'.(ES ·_-.-· ··- t-"-LA_1_1N_U_M_o_1A_M_1N_ll_o_1c_H_LO_fl_10_e_1TR_AN_s_1 _________ -+-------·t-· yEs .:.0._ES 1--.. POI.Y(4.VINYLf'YRIOINE), 25% CROSS-LINKF.O YES / . • 1-P-CL_v-_c_az_-L_Y::;_'1N_E _____________ ---IFF.RR o.~'-5100MOMGG ---·· ·yYEEs~· ·r· .NNOo":_7_· ··- POLY·DL-LYSiNE ,_P_ot_Y..,·D_L·_O_AN_1T_H_IN_E_f_1Y_o11_o_e_Ro....:.M_1o_F. _________ .._jFR~. 12~MG · .. .. YYEESS. _..!i_~ ! . __ POL Y·El'S!LON-CS-L-L YSINE PCLY·L·/\RG FR ··-· 200MG -.. YEs· ·No .. . ... _ "'"P-oL-Y--L--LV-.s-,N-e _________________ FR .. --·-· 1soMG ·yEs·· ·No · -- FOLY·L-Lvs1Ne HYDROeROMIDE EPF ·--· 25 MG I · YES ·---···- t-P-01-.Y-FT_H_Y-LE-·N_E_M-,M-,M-=---------------+-P-S-5QM[' ·r--YES . -··No -· 1-P-OL-Y-ET_H_Y_Ll:_N_IM-I-NE_A_v ___ A_Q_UE_O_U_S_S_OL_l)_Tl_O_N _______ ~.:..F'._~_ ·--· 1 L . --,· •. YYEEsS"•-'--··· ·--~--··- roL YOXYE.THYLENllSORBlTAN MONOOLE/\Tc t POTASSIUM DRO:.llOE cs .. 25 GM. YES ·-·· ··--- t-?-OT_A_, s-s-1u_M_c_A_l'l_ao_N_A_TE _____________ --i:-c-s-.. · -500G · __ .__ YES · ---· NO . l'OTASSIUM CHLORIDE PS/CS ___ 2OZ/500G YES .. NO .. l ·-- t-f'-OT_A_S_s_,u_M_C;..Y-AN_l_0!::1-PY_R_ID-IN_E ___________ --IFC · 15ML · YES NO I 1-P_oT_A_s_s1_uM_o_1c_HR_o_M_A_r1: _____________ 1-CP_S 0 _ 3 .. . ·1s 5 o 0 oGG ~~ ... YYEESs··· -!~-YES ·-+·~·- POTASSIUM fLOlJAIOE ... P_OT_A_s_s_1u_M_H_Y_DR_o_x_1o_e_(P_5_LL_E_Ts ... )._A_R_G_R_A_DF._, --------'--c_s_ 1 soo~ ·-, . . YES::-t° .. NO . ·-+-·. POTASSIUM HYDROXIDE (SOLUTION) 0,1N-1.0N _j_ YES-j 1-P-O-TA_S_S_IU_M_I_NM-,N-e-RA-l.--O-IL ___ ....... __ ~------1-c-s-·-' 50 GM . ! ... YEs1·· --~- ,-:-:--~:-:-::-~-:-~-:A-1:_e_TE ______________ ~~ ·· •. --I~~-;M .. 7_;~~--... _l _:N~ ~f--~ 1-P_o_TA_s_s_1u_M_?E_RM_A_N_G_A_NA_TE_. u_s_l'_G_RA_o_e ________ --i~P_S_ --~G . __ ... YE~... 1.... NO ·-- POTAss1uM PHOSPHATE, OIBASlC PS 1 KG 7 [ 1-P-oT_A_s_s1_u_M_PH_o_s_PH_A_T_E._M_o_N_o_eA_s_1c _________ ~CS/P~-=-. 1 ·~ KG(lSOG __ ·· -=.. I -=· /I ... ~ POTASSIUM, CHUNKS. IN MINEAAL OIL. 98% cs 50GM t-FR_e_a_N_A_N-_a_.o_Lo_N_.: _______________ --1-P.:..R_ .. _b ___ -~ · --~-.-· --r··-~.. ··t-... -.. 1-P_R_EG_N_A_N-_0_1o_L-_o_N_1: _______________ --i1--PR D __ .§.MG ····--·--· .,__ .. _ l-?_R_cc_A_IN_E_H_Y_O_Ro_c_1-1_Lo_R_1o_e_c_·R_YS_T_A_L _________ --4cs ---10~§__. -YES .. NO l--- FROGESTERON!l ·-'--· ·--'(ES -I Y,ES . ( ·- PRCPANEOIOL YES I 1-P-no-P-AN_O_t _______________ -!YFC"-· 20L--"'?Es ,·-No -· ,_:_::_:_:N_~:_L:_oi;_1-1_vo_e: _____________ --1-~P-CSS_f-.. _ .. ·-~1·0~0G_ML -~ ~-=~y-· EE~;S ... ·:l I . ·-NNOO .. ··r,. .. .._ PRO!'YLPENTANOIC ACIO SODIUM Page 16 10/22/96 12:15 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.139 P018 ,, Chemical Inventory April 22, '96 · PROSTAGLANDIN YES EPF --f!=j . ?ROlEAS!:, TYPE VIII 1100 MG YES PTERIN PS 100MG NO· YES .. . .. f'UfllNf CS/FR········ ..... ... N6 PUTRESCINf 25G/2G YES .. ----·--- PUTRESCINF. OIHYOAOCLORIDE YES ... _.,. __________ l'YRASOLE-1·11·1 ·CARBOXAMIDINE HYOROCHLORIDE,99% FC2 10gm NO ..... !10G ·-··· .. ··No-PYRAZINAMl:)E PS YES 150GM ·-··· --YES .. PYRA7.0~E-(1 H)-CAASOXAMIDINE HYDROCHLORIDE cs ·-.. YES PYRIDINE FC 1.5L NO ,,_., ... -· PYAIOINE, ANHYDnous FC1 1 L YES cs .. ···-. . .. ··--·--~ PYRIDINIUM P•TOLUENESULrONATE 5GM YES OUINIDINE HYOROCHLOR!OE MONOHYORATI, PS 10G-··· YES NO .. . .. ··--·-·--....... RADCON SUFACE CLEANER YES QC 1 GM·-.. RF.SOLVE-AL i YES , ...... , ______ -· RHOOAMINE 123 YES ... YES .. __ .. RlllOSE(DI ,S.PHOSPHATE OISODIUM I PRD ---·-------.G - RIBOSTAMYCIN SUI.FATE 100MG YES NO · PS .... ... flU'l HENIUM mm 250MG cs··· 2.5KG __ ,..,,. SAND ~ ..... -- SARCCJSINE cs 100GM YES NO 10GM ..... ··--· YES SARCOSINI: crHYL ESTER HYD!lOCHLORIDE cs ... L NO .. YES SCINTIVERSE i NO ,u, ... SEC-C!UTYL Al.COHOL FC-1 1LT YES PRO ·100G . S!:PHAPEX G·l50 ........... SEPHAOt:X c.;.2,00 cs 50G SEPHAOEX G-25 cs 50G ··-· "-' -----·-;---- ........ I __ ,;_ SEPHAOEX L-25 cs 50G -· . SEPHAOl::X LH-20 cs 50G YES '"' I SERUM HUMAN: TYl'e AB FnOZEN LIOUID ! NO . . ......... SIGMACOTE PR 100ML ! cs· .. _.,_, SILICA Gl:L. 200·400 MF.SH, 60 A 2KG i YES cs 1KG ! ·-··--·-· SILICA GEL·SO I .... ..... L. .. ,_,..,.,_,, ...... ... . , .. __ SILICONE': OIL, HIGH TEMf'eRATURI: WH 4L SILVER C::ARl:lONATE cs 25GM YES SIL VER N!TRI\ Tl: cs 25GM ---·YES -~---·---· SISOMICIN SULFATe PRD 1.25G YES Ps··--·-----• ,, __ _i. ____ SODIUM ACF.TATE 2KG "! SODIUM ACETATE ANHYDROUS cs 500G YES .............. SOOIUM AZIOE CS/PS 100G YES NO --· SODIUM BICARSONATE PS 500G YES NO ........ -u,,--, . ·--. SODIUM 81$ (TRIMETHYLSILYU AMIDI: CD3 100ML YES ·100G v'Es ---· -___ ,.,_,,_ SODIUM SOROHYDAIOc, 98+% cs NO i;ooG· •• • _,.,_, ___ ,.,, ••wo~ .. SODIUM CARllONA re CS/PS SODIUM CHLORIDC cs 1KG YES NO SODIUM CITRATE PS 1KG --· ... ..... YES ·-~--....... SODIUM O!A'(RllOLE ··-·- SODIUM HEPTANF.$UI.FONATE cs 25G 100G ,_,,., ........ YES ---··-No SOOIUM HYDR!Oc CD3 Page 17 10/22/96 12:15 ., CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.139 P019 Chemical Inventory April 22,'96 SODIUM HYOROGENSULFITE cs 500GM YES I ~500GM ·-· ......... I SOl"llU:1.-1 HYOROGENSULFITE, A.C.S. REAGENT cs 56oG -·------··-SODIUM HYOROXIDE {PELLE1'S). ACS GMOE cs YES NO ..... .. SO::>IUM HYDROX!Di:, IN PS 1L l YES l I ·co3 5GM .. i ... . .. SODIUM HYDROXICE, 60% DISPsRSION IN MINERAL OIL cs ";500ML YES . ·······- SOQ!UM HYDROXIDE. 6N cs 100 GM .. SCJOIUM 10D1D1: YES .. ·-SODIUM METHO)(IOE cs 500G YES NO -· - SOOIUM PENT ANES\Jl.l'ONATE PS 100G SODIUM PHOSf'HATE (DiBASICJ, ANHYDROUS PS 2KG ...... YES NO PS 500G . ·······-YES . S001\JM PHOSPHATE {MONOBASICJ, MONOHYDRATE NO . .. SODIUM PHOSPHATE rrRIBASIC). cooec.,HYDl?ATE YES NO SODIUM POTASSIUM TARTRATc PS :500~:--....... SODIUM SELENITE CELL CULTURE "f!:Sl'l!D I YES i .. SODIUM SULFATE YES NO SODIUM SULFATE ANHYDROUS CS/PS 3°KG/1.5KG YE$ NO 500GM YES ---··-·"' .... SODIUM SULFffE cs NO M ...... .. . .... SODIUM TIIIOSUL.FAT!; PS 500G YES NO .............. SODIUM 'IHIOSULFATE ?tNTAHYORA75 I YES __ ,_ .. ,. -________ .,,. ___ 1----:-- SODIUM, LUMP IN Kl:ROSENE YES ___ , .... j25GM SODIUM, LUMP, IN KEROSENE cs ...... _ ... SOMATOSTATIN-(SAL T} FR 5MG PR·ti·· ... S:'ECTlNOMYCIN OIHYDRCCHLORIOE 1G YES NO I PR o ···-··· -- S?C<:TINOMYCIN $04 1G FR.D/PR D ... .. S!'ERMIDINE 5G/1G EPR SGM Yes .. ··-----Si'l:RMINE -·--···· ·-..... .. . -· ·--·· .. SFE:RMINE DlHYDRA TI: FR 5G YES -· SPE:RMINE FREE BASE YES ·---···-···-SPERMINE 1 ETRAHYOROCHLORIDE FR 1G YES . SPHINGOSINE FR 5MG STARBURST {PAMAM) OENDRIMEF!, GENEflATICN 0 CHEM . 125-GM ···-·-· YES ........... , .. _, ....... ·--·· ,_,. - Sl"ARBURST {l'I\MAM! D!lNORIMER, GENERATION 1 CHEM 50GM YES ·-. . . . STAR8URST(f'AMAM)DENDRIMER, GEN 0 FC1 25GM ! YE:S FC1 ]5GM YES ..... ··--............ ------STARP.URST(PAMAM)DENORIMER, GEN 1 PR )1o·o"MG. . ·---··-··--" -- STRf PTIOINE $04 EPF i4L ..... ·--•"' ...... -·-r----·- STRF.PTOALLOTEUCEUS HINDUSl'AN\JS l::XTRAC. i I .. -·-STRF.PTOMYCIN SULFATE PRD l125G -····ves· NO ! .. -····-· ...... I . ......... STRPTOMYCES l'RADIAE EXTRACT PR ti · ··:1cr· · i l I SUBSTANCE? PRD ;1MG YES NO I 1 . -i500 GM ·-·· ········ . ··-i SUCROSE cs YES NO ...... $Ut:fURIC /\CID, 36N AC j15L YES NO . i ..... _ ........ r1 KG .. .... -·· .... ,_ ........ TERACETIC ACID PS I Tl'RT.$UTOXYCARSONYt.(Nl-PYRAZ01.f(lH)·:;AR60XAMIOINE(1) cs ]5GM I ;i[f"·--···· ....................... ,!,--.......... TtnT-BlJTYl.. AI.COI-IOL FC-1 YE:S i .... ··- n:1-1 r-BUTYLCHLOROOlr'HENYLSILANC CD3 /50GM YES I I ··---TERT-6UTYl-CHLORODIPMENYt.Sll..ANli,9B% FC2 '10GM YES ...... __ ,. __ TERT,P.UTYLOIMETHYLSl:.YL CHLOAIOE,07% FC2 25GM i YES ___ ,. TETRAAMINOPYRIMIDIN6:..?.,4,5,6 SULl=ATE cs 25GM i YES __ , ....... l-YES fErRAAZACYCLOrENTAOECANE Page 18 10/22/96 12: 15 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.139 P020 Chemical Inventory April 22,'96 i-·-~_. l'l_A_A_ZA_cv_. c_L_o_TE_T_R_A_DE_C_A_N_e _1,_4._s_.1_1 _________ -1-------!-1_G __ M ·-· ·-. l YES -.1 ------· ..... ···- TF.Tl'lAAZACYClOTETRAOECANE 1,4,8,11 5 GM 1.· YES ! TETRAAZACYCLOTETRADECANE· 1,4,8.11J-1,4,8, 11,TETRAACETlC ACID 250 MG YES f 1----------..;_....;.__;_..;_;._;_ ________ ~-----~----...!'-I TETMBENZYL PYROPHOS?HATE i ·--YES 1 1--------------------h-::-----+-:-:-=-::--:----;..--:-:=--...!·----...... .. TE"fHABUTYLAMMON1uM BROMtoe 10 GM I YES. ·--"1"----·--· .• cs cs ts .. cs ---........ ·- TETRA!:lUl'YLAMMONIUM 1-LUOR!OE 100 ML \ YES ! :T=ET=fi=A=B=UT=Y=LA==M=M=O=N=IU=M=H=Y=O=R=OX=l=DE==S=O=LU=T=IO=N=IN==W=A=TE=fi========:~=====-... -__ -.-1.1-__ -. -.. -.. -. --··r ...... YES ...... T .. ---·-.. - TETRAl3UTYI.AMMONIUM IOOIDF. 25 GM j YES I FC1 cs TETRABUTYLAMMONIUM-S04 1 OOG i i TETRI\CYANOllCNZCNC (1,2,4,5) cs 5 .GM .. l .. YES-· t ......... _. :T=E=TR=A=E=TH=Y=L=EN:E:F:EN:T:l\:A:M:!N:e:P:EN=T=A=H=Y=OR=O=C=H=LO=R=IO=E===========~i-:c;_s:;__ ____ ...:5...:0_·G.:.-..:..M..:.. __ ._·-_·-_--i ·-YES i ·-_., __ TET,IAETHYLTHURAM DISULFIDE PS 100G I YES ! NO - I-TE-TR-AH_V_O_RO_l'_UR_A_N _____________ --IFC/FC2 ... . 4U2L ; YES i NO cs ... TE_-TR_._A_H_Y_Dn_o_r_u_nA_N_AN_I_iY_c_n_o_us_._s_s._s_% _________ -'--F_C_1 ___ -'--1-"L_T___ . -·· Yes·· ···i .... ·-·--· TETRAHYOROFURAN, ANHYDROUS, 99.9% cs 1 LT -YES l------------------------1------1-.. -, .. 1 i: T"IAM1:1 HYLtN,N,N' ,N·i-1,8-NA!'H'rHALENE OIAMINE YES TE7RAMETHYLAMMONIUM HYDROXIDE cs 100.ML YES ....... TE7RI\ZACYCLOTETRAOECI\NE FR D 1 G YES NO 1------------------------1------1---· TE:,RAZOLE( 1 H) cs 5GM YES 1-T-HI-OA_N_IS_C_L_e ________________ .,_c_s--······ 100G YES t--------------------------4 .... THION:N, CERTIFIED I YES THIONYI. CHlORIOE 1100G .... YEs···--..... _°N_o---'--··-· -------+----·-·. ... r_H_I0_1J_R_EA_._9_9_+_%_, _A._c_.s_._RE_A_G_E_NT ___________ -'--____ ...,i_5_0_G_M ___ . ! YES YES THROMBIN FROM BOVINE PLASMA 1000UN ; YES 1-TH-RO_M_B_IN-l'R_O_M-HU_I-/._.A_N_Pl_A_S_M_A ___________ --'-----.. ••· • j YES i ··•·• .. , ____ ..;_ __ _ . ,._ ... __ _ NO .. ..... -, . .....;.i---1 FC cs EPF TITANIUM(IV! CHLORIDE 800 ML I YES i YES TlTANIUM(IV) iSOPffOPOXIOE ••• 100 ML .... L_Y_E_S _ __,;1 _____ ~ ·.·.-.----- TORRAMYCIN 200MG YES NO TOLUrnE .• .._4_L ___ ---1, __ Y_E_S_ ... _ ....... NO cs cs PRO FC2 1-------------------~-----1------1-----.... TOLU£N5(PJ SULFQNIC ACID MONOHYDRATE YES --4-----~----........ . . -· .. FC1 TOLUENE, ANHYDROUS 1 LT ,oLUEN1:suLF0Nv:.cHLoR1oe 100G YEs .. ··---····No FC2 ToLuI01Ne .. NAPTHALeNesuLF0Nrc Aero 5G ···--·· Yes --· ··No cs ------1-----.. ----..... TRANS•: .i.cvc1.0HEXANF,D!CARBOXYLIC ANHYDR!Oli, 97')(, 10 GM ----------------------1------1----· ... TRANS·~.2-0!AMINOC:YCLOHEXAN!;: 50 ML 1-T-RA-Ns-.-2.-N-O-NE_N_e ________________ -+------4ffGM YES ........ --1------...J-..... -. cs cs cs : ..... ,-~---·· rRl·N·OCTYLAMINE YES TRIAMINOPYRIMIOINE·2,4,6 25 GM ··-·yes 1-m-,-!A_M_T-ER_li_N_E ___________________ -+------1-1G · cs PS .......... -------··· .... ··--1----.. ···---·· TR:AlACYCLONONANl:• l ,4,) YES TR:RUTVlAMINF., 99¾ cs __ ., 50ml . ··-----...J-----... TRIC:HLC)R0·1, 1,2·TRIFLUOnOETHANE: YES TRICHLOROACETIC ACID, ACS GRADE cs .. .. ··-···-YES 250G ·: NO -----~------· TRICHc.OROANILINE(2,3,4) cs 5GM YES -· ..... ---1---··-· .. TRICH~OROETHYL ACETATE (2,2,2,·) CD3 1ML YES ... TRICHLOROETHYL BUTYRA'fl:(2,2,2·1 CD3 PS TRICHI.OROTRll'l,UCROETHANE(1, 1,2J 1 ML 1Lt YES ---1----· ... ----·· TRIETHANOLI\MINE PS 250G ...... __ TRIETHYL ORTHOFOF;MATE,ANHYORO\JS.28% FC2 1 L, 100ml YES Page 19 <' 10/22/96 12:16 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 N0.139 P021 Chemical Inventory April 22,'98 :::,::;••n ~~ . l~~~L ·--~~ + ~~ 1· ·-~T-R1-E1_H_Y_LT_ET_R_A_A_M-1N_E_T_Er_RA_Hc_1 ____________ PS ···-zsG ·--,--· YES NO ·- I-T-AI-FL_U_O_AO_A_C_;T-IC-,-A-NH_Y_O_HI_D_E,-9-9•-;-.-----------4.FC2 ·-1oo GM ----· Y~s ; ,---- TRl~LuRoAcrnc /\c10 AC ··-3L --· YES N(? _ __:r-··- t--T-R:-FL-u-no_M_E_T_HA_N_E_S_Ul_F_ON_I_C_H_YD-_R-IO-E----------1CD3-· 1 OG ---· ·---·· · 1-TR_I_KE_-:-_o_HY_o_A_IN_D_EN_c _______________ Ps ·--t10G · ____ ·:--Y~S ~---NO. I .- TRIMESIC ACID + TRIM!:THYL PHOSPHITE, NMR GRADE mtMETHYLACETYLCMLORIOE ,=·c· 1 --o.,GM .• r YYEE __ ss_ .. I·-· . . I-_-.. Tr!IME.THYLAMINE, ANIIYOROUS :'"'::-:1_:=~-,=~-T=::-:-~=:o:-H:_o=;s_H=;_o:;:-,~:-::-~o:-An_T=l::-E.:-_=:-_=:-_=:-_=:-_=:-_=:-_=:-_=:-_=:-_=:-_=:-_=:-+_=g....,..r ·_ I ::;M. : t" : ~r =~~-:: J- TRll'HENYL?HOSPHINE OXIDE, 98% cs 25GM YES ~ 1-r_R1_l't-1_o_Pv_L_AM_1_NE _______________ -1sc1 ·--· soo ML _ · 1 . YES_ · _ ___.=- 1 TRIPTAMINC CS 10 GM 1-TR-,-PT_O_P-HA_N_-L_M_e_r_H_YL_e_ST-ER_H_YD_Ro_c_H_Lo-R-,D-E-------+-c""'s_.. • s GM ·1·· .. -.-· · --· :::~;::::::~:::::,,.% ~1 · . ··!t~L ~. ~~-· r-.. .. --=~ I-TR-I-S(-H-YO_R_O_X_YM_E:_7!_1_YL-)A_M_I_NO_M_E_T_HA_N_E----------+· ___ 7-· ·-·--.--·· .. YE_S . ' NO --·- t-f-fll-S--18_!:_NZ-.IM_I_O/\_Z_O_L_YL_M_E_TH_Y_Ll_A_M_IN_E _________ -IPS ~· 1 G YES NO i-~-::-:;_:_:-1:_:_:;-,L-;o-~-1:_:_e--------~------~-~-D-.~--. ~~G:. ~f-·_--YES ::+-~ NO -:·t_-~ .. TRITON x-100 t YES :.t 1-T-RI_Z_M_A_BA_s_1:_R_=A_G_E_N_T_G_RA_D_!! ___________ -f-cs.. . . . --· YES -. . -•. TRIZMA HYOROCHLORlni; ·-- TAOLOX 1ROLOX(R)-( ~l Sl8% CS "fROLOXISH·l 98 % C$ TROLOX, 97% C$ ···-1' . t-T_Rv_. r_A_N_s_Lu_e_s_o_u_m_o_N_c_e_LL_c_u_Lr_u_R_!! ----------1 ···--·· L . YES ·--·· ~----. - ~~ + 1-_l-l'IY_P_T_OP_M_A_N_IL)_M_E_T_HY_L_E_S_TF.-.R-H_Y_DR_O_C_H_LO_R_lO-E--------+--· ! . . "' YES . ---· TWEEN 20 Ps ·-soci'ML ------.. · -·j 1-TW-t::E_N_SO---------------'---+PS_~ 50.05~MMGL_ l. YES ··-·v~sJ--~---- 1-T_YR_·Cl_'·G_-_F-L_-R_-K_R _______________ +P_R_D_ ----+·· YYEESS . ·--NO i • TYROSINE!LJ URIC ACID FREE ACID SIGMAU~TRA .• ·-i--• . I' YE°s" ·--· t------------------+-F-R-=-D -1---1M·G ·--i,· YE._S No-· --VAL·ARG-t YS·AllG-THR-LEU-ARG·ARG·Ll:lJ VERAPAMIL IIYDROCHLORIOE ·-1--. ·1· Y0ES • ·-.• 1-v_,N_vL_A_c_ET_A_n_:· -----------------IEPR -~ ·1· LT,-~ .. I ·yEs· ·y~sj ·=- VINYLBeN2:0ATE EPF 100 ML f YES l- ______ ...;.;... _ ___;_,;.._ ______ +.E;;;; .. .;..._P!3___ -1___-00_~N-.. ___ .. y· ES __ =:-.. . .. X!\NTHINI: OXIQASE FROM MICROORGANISM ~· __ _ XANTM1Nr: SODIUM CELI. CULTURE TE:STEn YES ' XANTHOS1NE 5',0IPHOSrHA"'c soo:uM ··--·-·· : .. YES · -·-· J ·-· 1-x-v1-.e-N~E-------------------t--·--· ·-+ YEs··· ·----• .. _ - xYL0s1As:NFR0Ma11c1LLussPEc1l!s PR o--·· 1MG. i·--vEs ... -,-··No ·t·· 1-x-vL-Y-Lt--N-=o-,A-M-IN-e-.M---------------+-c-s-• j100 GM_.. YES· --.. i ·-- Page 20 •l I l 1 ' ~ . . ,., 10/22/96 12:16 CYPROS PHARMACEUTICAL CORP~ 619 438 0046 Chemical Inventory April 22,'96 XYL YLeNt:OtAMINE•P• cs J5GM ___ 2CROSTA1. AN1HlTATIC INSTRUMl!NT CH.EM cs ·--500GM. ZINC ACETATE DIHYOAATE ZINC CHLORIDE, 1,0M SOL'N IN D11.THYL ETHER cs .. _ 100 ML. Page21 N0.139 P022 YES ·--· --· - ---· ··-·· ·-·- ···-·r-Es ·--·e--- 10/23/96 OCT-23-96 WED 14:03 Hazar..dous Materials 14:09 4380894 CITY OF CARLSBAD COMM DE FAX NO, 4380894 ·· • SAN DIEGO REGIONAL .. .. . HAZARDOUS MATERIALS QUESTIONNAIRE P.02 --. -. ' ~ Management Division C'tnn ., u• , ... , PART I: FIFIE OEP'A,RTM~NT • MAZARDOUS MATERIAi.§. M.ANAG!:MENT DIVISION: OCCU,fANCY CLASSIFICATION lndicati, by cin:iling the 1t11m, whtn:her your l>Utiness Will use, process, or store any o1 ttie rollowin; hazardous materials. lf anv ot tha items er• circled, applicant must contact the Fire P,otaction Agwncy with juri,sdiedon prior ,:o plan submittal . . Explo$ive or 91a$ting Agenta Flammeble Solids (ij Pyrophorie• IC,yogenica (W Corrosives Comp,e,aed Gaaes, 0rwanic f'eroxidn . Unstable Reactlva HiQNY Toxic or To,ac Matetials 14. Other Heeltl'I Hazards Flammable ot Combustible t,.iquids 0,cidiz,m1 9 Water Reectives 2 Radioactiv1t!!I PART U: COUNTY OF SAN DIEGO HCAL'tt;! DEPARTMENT· HAZA~DCIJS; MAmJA~S MANAGEMENT p1VISl,ON: CONTINGENCY PLAN REVI~ If the answer to anv of the q111111tii:m11 i11 yn:, applicant must contact the County of San Dilt{IO Ha:i.,dous Materials Management Cl11ision, 1 2$6 lmc,eriel Avenue, 3rd Floor, S•n Dl"9Q, C/4. 9218&-6261. Tol-.phomt U319> 338·ZZZ2 prior to tho iHuancl!J of a b1,1,lding i:,efmit. FEES MAY SE REQUIRED 1, I§ Is your bu1inu1 liltecl on the reveNa •• or ttlil rorm7 , z. Will YO\lr b\llliness diSJJ0H of Mmardou1 Suo1taneH or Medical W•t• in eny emount"I' 3. c::J WIii your business store or nandle Hazilrdous Substances il"I quentities equal to or greater t'1Bn 55 gellons, 500 pound•. 200 cubic feet or carcinogens/reproductive toidl'III in •nv qu•ntity7 4, Will your businffs use an existing or iflftall an underground storage tank' 5. Will your bl.lsiness stor• or handle Acutely Hazardou• Materi,llls1 · OFFICE use ONL y O RMPP Exempt I Cate Initials 0 RMPP Required Oate Initials PAR"t Ill: SAN Cll<CO COUNTY AIR PO!:,LUTION ,CONTROL OISTAICT If the answer to ,11ny of the questions i• yes, applicant mu•t i;;;ontac:t the Air PQll~oo Control Oistriet, 9150 Chosapeaka Drive. S.an Oiego, CA 92123. TelephQne !61 694--3307 prior to the issuance of a building permit. YES 0 1 . c:J Will the intended occupant install ar UN any of the equipment listed on the Uating of Air Pollution Control District Pormit Categories. on the reverse side of this fonn7 . 2. c:::J c::J (ANSWER ONLY IF QUESTION 1 IS YES.) Will the subject facility tte locaud within 1,000 ffft of th• ou1tt boundary of II school CK through 1 2) n lilted in the current Directory ot SchOOI anc:1 Comt'Nll'litv con•ue Dietncu, publi1hed by the San Diego County Offic• of Edueation end tl'le cur,ent C:alitc.rt'lia Prtv.a Sc"~ Oit6<:,oty, c:QMPiled il'I .ccordtme9 with proviacm11 o1 lictuoation Code Seotion 331907 true F!RE OEPAATMENT OCCUPANCY CI.ASSIRCATION: _________ __,......., ....... -----~--------------BY: _________________________________ Date: _______________ _ Ex E.tivifDIIIIC:IMii Heallb Sen'ica DHS:HM-9171 (6/9J) 0 COUNTY•HMMD APC0 - ?.-711.f l-c>~ ftV uJ lft ~ i,..JceR4 '-1 t. H'd Sf l.,-I OD ('_;.,i,~,,, 1(-V,/f(..,. -1)'.-C:,~ q h g_, {'-f \ ti) /( I 4/ rt -P rf u'J, 0, --:f ~ .J-IJ .{,f L... k.,/ (f'7_,.,.,.:1,'J;;:. ~ ,;,,t-'-fll e,Ji,o ~ UV'.. '( APPROVALS I I /r'>/ "t? C UV}' D~ . ' C, u/r,.j,:=, /J-· u.. Ge (/l,\___ 1. c } /'f (/Ip . I"'-J-c/ffuuildi?g --J jv ~/ Planning riMr? (j,"4 . I E?gineer'Jlg t ~.:.L-.1:-J1.-Fire. /;i_// 3[qb-~ f'J4f-:;J/~ <fr g'~(C 7.'-bw_ =====~::::I ( i/7;,Jffe C f q_ i v1 ca t-lr ~ ~<Z-.S. ~ i \-[14t[D (c ~~ CL»A--- l . ~{&( 1h ,/ iJ1,7 1Z M ;;-~ "P d I e/r-1 -RT f' I/_,{ t q-J -,c-,; J Y,c~lu,.) l i,_i/~"/ ~-f~ F~NAlED \ L '.' l ·, t-f' ·, _____ Assoc. DATES To From Aoolicant Aoolicant ii /f../l'IL HAZMATFORM INDWASTEAPP SCHOOL FEE FORM PLAN CORR ENGRGCORR BUSLIC WCOMP FIRE PLANS ASSESSOR PLANS COFO